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NAA20 Gene

protein-coding   GIFtS: 52
GCID: GC20P019997

N(Alpha)-Acetyltransferase 20, NatB Catalytic Subunit

(Previous names: N-acetyltransferase 5, ARD1 subunit (arrest-defective 1,...)
(Previous symbol: NAT5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N(Alpha)-Acetyltransferase 20, NatB Catalytic Subunit1 2     NAT32 5
NAT51 2 3 5     N-Acetyltransferase 3 Homolog (S. Cerevisiae)1
N-Acetyltransferase 5 (ARD1 Homolog, S. Cerevisiae)1 2     NAT3P2
N-Acetyltransferase 5 (GCN5-Related, Putative)1 2     NAT5P2
N-Acetyltransferase 5, ARD1 Subunit (Arrest-Defective 1, S. Cerevisiae,
Homolog)1 2
     dJ1002M8.12
N-Acetyltransferase 51 3     N-Acetyltransferase 3 Homolog2
Methionine N-Acetyltransferase2 3     N-Alpha-Acetyltransferase 202
NatB Catalytic Subunit2 3     N-Alpha-Acetyltransferase 20, NatB Catalytic Subunit2
NatB Complex Subunit NAT52 3     N-Terminal Acetyltransferase Complex ARD1 Subunit2
N-Terminal Acetyltransferase B Complex Catalytic Subunit NAA202 3     EC 2.3.1.883
N-Terminal Acetyltransferase B Complex Catalytic Subunit NAT52 3     

External Ids:    HGNC: 159081   Entrez Gene: 511262   Ensembl: ENSG000001734187   OMIM: 6108335   UniProtKB: P615993   

Export aliases for NAA20 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NAA20 Gene:
NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal
acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 (PubMed
18570629)).(supplied by OMIM, Apr 2009)

GeneCards Summary for NAA20 Gene:
NAA20 (N(alpha)-acetyltransferase 20, NatB catalytic subunit) is a protein-coding gene. Diseases associated with NAA20 include eastern equine encephalitis, and encephalitis. GO annotations related to this gene include peptide alpha-N-acetyltransferase activity.

UniProtKB/Swiss-Prot: NAA20_HUMAN, P61599
Function: Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues
of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are
overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin
fibers and for proper cellular migration

Gene Wiki entry for NAA20 (NAT5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011387.9  
Regulatory elements:
   Search for regulatory transcription factor binding sites for NAA20
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAA20 promoter sequence
   Search Chromatin IP Primers for NAA20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAA20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.23   Ensembl cytogenetic band:  20p11.23   HGNC cytogenetic band: 20p11.23

NAA20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAA20 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P019997:  view genomic region     (about GC identifiers)

Start:
19,997,760 bp from pter      End:
20,014,299 bp from pter
Size:
16,540 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NAA20_HUMAN, P61599 (See protein sequence)
Recommended Name: N-alpha-acetyltransferase 20  
Size: 178 amino acids; 20368 Da
Subunit: Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25
Sequence caution: Sequence=BG548527; Type=Frameshift; Positions=111;
Secondary accessions: A6NHA3 B2R4G4 Q5TFT7 Q9D7H8 Q9H0Y4 Q9NQH6 Q9Y6D2
Alternative splicing: 2 isoforms:  P61599-1   P61599-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NAA20: NX_P61599

Explore proteomics data for NAA20 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys124
  • Modification sites at PhosphoSitePlus

  • See NAA20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_057184.1  NP_852668.1  NP_852669.1  

    ENSEMBL proteins: 
     ENSP00000335636   ENSP00000311027   ENSP00000381603  

    NAA20 Human Recombinant Protein Products:

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    Novus Biologicals NAA20 Protein
    Novus Biologicals NAA20 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    NAA20 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for Antibodies for NAA20 at Abcam
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    LSBio Antibodies in human, mouse, rat for NAA20

    NAA20 Assay Products:

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NAA: N(alpha)-acetyltransferase subunits

    2 InterPro protein domains:
     IPR000182 GNAT_dom
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry P61599

    ProtoNet protein and cluster: P61599

    UniProtKB/Swiss-Prot: NAA20_HUMAN, P61599
    Similarity: Belongs to the acetyltransferase family. ARD1 subfamily
    Similarity: Contains 1 N-acetyltransferase domain


    NAA20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAA20_HUMAN, P61599
    Function: Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues
    of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are
    overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin
    fibers and for proper cellular migration
    Catalytic activity: Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA

         Enzyme Number (IUBMB): EC 2.3.1.881

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004596peptide alpha-N-acetyltransferase activity IEA--
    GO:0008080N-acetyltransferase activity ----
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
         
    NAA20 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Naa20 (no phenotypes)

    NAA20 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NAA20
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NAA20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NAA20
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NAA20

    miRNA
    Products:
        
    miRTarBase miRNAs that target NAA20:
    hsa-mir-192-5p (MIRT026585), hsa-let-7b-5p (MIRT052094), hsa-let-7d-5p (MIRT032114), hsa-mir-215-5p (MIRT024560)

    Block miRNA regulation of human, mouse, rat NAA20 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAA20 (see all 10):
    hsa-miR-320a hsa-miR-140-5p hsa-miR-22 hsa-miR-3140-3p hsa-miR-1266 hsa-miR-320d hsa-miR-548b-3p hsa-miR-320b
    SwitchGear 3'UTR luciferase reporter plasmidNAA20 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NAA20
    Predesigned siRNA for gene silencing in human, mouse, rat NAA20

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NAA20

    Clone
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    OriGene clones in human, mouse for NAA20 (see all 17)
    OriGene ORF clones in mouse, rat for NAA20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NAA20 (NM_181527)
    Sino Biological Human cDNA Clone for NAA20
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAA20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAA20

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NAA20 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA20


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NAA20_HUMAN, P61599: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    NAA20 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NAA20 About    
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    metapathway biotransformation0.42


    1 BioSystems Pathway for NAA20
        metapathway biotransformation



        Pathway & Disease-focused RT2 Profiler PCR Array including NAA20: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NAA20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NAA20 (P615993 ENSP000003356364) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607093, ENSP000003499604I2D: score=1 STRING: ENSP00000349960
    DDX31Q9H8H23, ENSP000003612324I2D: score=2 STRING: ENSP00000361232
    PSMC4P436863, ENSP000001578124I2D: score=2 STRING: ENSP00000157812
    PSMD14O004873, ENSP000003865414I2D: score=1 STRING: ENSP00000386541
    NOC2LQ9Y3T93, ENSP000003179924I2D: score=3 STRING: ENSP00000317992
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAA20



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NAA20 gene (3 alternative transcripts): 
    NM_016100.4  NM_181527.3  NM_181528.3  

    Unigene Cluster for NAA20:

    N(alpha)-acetyltransferase 20, NatB catalytic subunit
    Hs.368783  [show with all ESTs]
    Unigene Representative Sequence: BE868948
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334982(uc002wrp.3 uc002wrq.3) ENST00000484480 ENST00000310450
    ENST00000463154 ENST00000480550 ENST00000398602(uc002wrr.3) ENST00000481837

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NAA20 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAA20 (see all 10):
    hsa-miR-320a hsa-miR-140-5p hsa-miR-22 hsa-miR-3140-3p hsa-miR-1266 hsa-miR-320d hsa-miR-548b-3p hsa-miR-320b
    SwitchGear 3'UTR luciferase reporter plasmidNAA20 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NAA20
    Predesigned siRNA for gene silencing in human, mouse, rat NAA20
    Clone
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    OriGene clones in human, mouse for NAA20 (see all 17)
    OriGene ORF clones in mouse, rat for NAA20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NAA20 (NM_181527)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAA20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAA20
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NAA20
    OriGene qSTAR qPCR primer pairs in human, mouse for NAA20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAA20
      QuantiTect SYBR Green Assays in human, mouse, rat NAA20
      QuantiFast Probe-based Assays in human, mouse, rat NAA20

    Additional mRNA sequence: 

    AF085355.1 AK311819.1 AL136641.1 BC005181.1 BC008446.1 

    14 DOTS entries:

    DT.445120  DT.100698567  DT.97768901  DT.100021147  DT.99971912  DT.100746561  DT.120826149  DT.40121431 
    DT.91823036  DT.100819175  DT.92437400  DT.40266449  DT.95182041  DT.97847480 

    Selected AceView cDNA sequences (see all 328):

    CR607693 BI488948 NM_181528 CA868412 AI458465 CB305471 AF085355 BE857386 
    CR597980 AA314886 AA759323 NM_181527 AW024136 BM015980 CA848171 BM314589 
    BU852320 BU072300 NM_016100 BU752497 BQ267945 H25087 CA867744 CR623548 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NAA20    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                      
    SP2:                                      -               
    SP3:        -     -                                       
    SP4:                                                      


    ECgene alternative splicing isoforms for NAA20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NAA20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCATAGTA
    NAA20 Expression
    About this image

    NAA20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAA20 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368783
        Pathway & Disease-focused RT2 Profiler PCR Array including NAA20: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NAA20
    OriGene qSTAR qPCR primer pairs in human, mouse for NAA20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAA20
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    QuantiFast Probe-based Assays in human, mouse, rat NAA20
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NAA20 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Naa201 , 5 N(alpha)-acetyltransferase 20, NatB catalytic subunit less1, 5 91.01(n)1
    99.44(a)1
      2 (71.28 cM)5
    678771  NM_026425.31  NP_080701.11 
     1459020995 
    chicken
    (Gallus gallus)
    Aves NAA201 N(alpha)-acetyltransferase 20, NatB catalytic subunit less 81.65(n)
    98.31(a)
      424333  XM_422177.4  XP_422177.1 
    lizard
    (Anolis carolinensis)
    Reptilia NAA206
    N(alpha)-acetyltransferase 20, NatB catalytic subu...
    91(a)
    1 ↔ 1
    4(80510652-80519203)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044290.12   -- 82.01(n)    BC044290.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM005251.12   -- 79.36(n)    BM005251.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG142221 CG14222 68.02(n)
    71.1(a)
      32962  NM_134487.3  NP_608331.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y97E10AL.31 Y97E10AL.3 60.31(n)
    61.85(a)
      190814  NM_072652.5  NP_505053.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NAT3(YPR131C)4
    NAT31
    Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met less4
    NAT31
    52.68(n)1
    48.28(a)1
      16(794498-793911)4
    8562491, 4  NP_015456.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G031501 AT1G03150 60.62(n)
    61.4(a)
      839562  NM_100197.2  NP_563677.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g06994001 Os03g0699400 61.21(n)
    62.57(a)
      4333816  NM_001057523.1  NP_001050988.1 


    ENSEMBL Gene Tree for NAA20 (if available)
    TreeFam Gene Tree for NAA20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NAA20 gene
    1 SIMAP similar gene for NAA20 using alignment to 2 protein entries:     NAA20_HUMAN (see all proteins):
    NAA10

    NAA20 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for NAA20
    PGOHUM00000239370 PGOHUM00000243953 PGOHUM00000241550


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NAA20 (see all 374)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1922372631,2
    --19995999(+) ACAGGA/TGAGAA 2 -- us2k10--------
    rs60355131,2
    C,F,A,H--19996058(+) ACGTTC/TCCCTG 2 -- us2k17Minor allele frequency- T:0.20NS NA CSA WA EA 484
    rs745218441,2
    C,F--19996120(+) CTCAAA/GATCGG 2 -- us2k12Minor allele frequency- G:0.31CSA WA 120
    rs800119481,2
    F--19996123(+) AAAATC/TGGAAT 2 -- us2k12Minor allele frequency- T:0.08CSA WA 120
    rs60465381,2
    C,F,A--19996142(+) GTATCA/GGTGCT 2 -- us2k112Minor allele frequency- N:0.00EA NA WA CSA 554
    rs60818381,2
    C,F--19996193(+) CCAATG/ACTACC 2 -- us2k15Minor allele frequency- A:0.11NA WA EA 362
    rs1464477291,2
    C--19996330(+) AATATC/TATAAA 2 -- us2k10--------
    rs1408418761,2
    --19996420(+) AAATGG/TCCAGA 2 -- us2k10--------
    rs1431610371,2
    C--19996551(+) CCATAA/GAATAC 3 -- us2k10--------
    rs1466359431,2
    --19996576(+) ATACAC/GTGCCC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for NAA20 (19997760 - 20014299 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NAA20:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665704CNV Deletion23128226
    nsv179610CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610833    OMIM disorders: --

    6 diseases for NAA20:    
    About MalaCards
    eastern equine encephalitis    encephalitis    hypoxia    colorectal cancer
    malaria    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NAA20:
    Eastern equine encephalitis

    NAA20 for disorders           About GeneDecksing


    Export disorders for NAA20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NAA20 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with NAA20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PubMed id 19660095)1, 2, 3 Polevoda B.... Sherman F. (BMC Proc. 2009)
    2. Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression. (PubMed id 18570629)1, 2 Starheim K.K....Lillehaug J.R. (Biochem. J. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation. (PubMed id 19716809)1, 9 Kuo H.P....Hung M.C. (Biochem. Biophys. Res. Commun. 2009)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)1 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51126 HGNC: 15908 AceView: NAT5 Ensembl:ENSG00000173418 euGenes: HUgn51126
    ECgene: NAA20 H-InvDB: NAA20

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NAA20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NAA20 gene:
    Search GeneIP for patents involving NAA20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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