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Aliases for NAA20 Gene

Aliases for NAA20 Gene

  • N(Alpha)-Acetyltransferase 20, NatB Catalytic Subunit 2 3 5
  • N-Acetyltransferase 5, ARD1 Subunit (Arrest-Defective 1, S. Cerevisiae, Homolog) 2 3
  • N-Terminal Acetyltransferase B Complex Catalytic Subunit NAA20 3 4
  • N-Terminal Acetyltransferase B Complex Catalytic Subunit NAT5 3 4
  • N-Acetyltransferase 5 (ARD1 Homolog, S. Cerevisiae) 2 3
  • N-Acetyltransferase 5 (GCN5-Related, Putative) 2 3
  • Methionine N-Acetyltransferase 3 4
  • NatB Complex Subunit NAT5 3 4
  • NatB Catalytic Subunit 3 4
  • N-Acetyltransferase 5 2 4
  • NAT5 3 4
  • N-Terminal Acetyltransferase Complex ARD1 Subunit 3
  • N-Acetyltransferase 3 Homolog (S. Cerevisiae) 2
  • N-Acetyltransferase 3 Homolog 3
  • N-Alpha-Acetyltransferase 20 3
  • EC 2.3.1.88 4
  • DJ1002M8.1 3
  • NAT3P 3
  • NAT5P 3
  • NAT3 3

External Ids for NAA20 Gene

Previous HGNC Symbols for NAA20 Gene

  • NAT5

Summaries for NAA20 Gene

Entrez Gene Summary for NAA20 Gene

  • NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 [PubMed 18570629]).[supplied by OMIM, Apr 2009]

GeneCards Summary for NAA20 Gene

NAA20 (N(Alpha)-Acetyltransferase 20, NatB Catalytic Subunit) is a Protein Coding gene. Diseases associated with NAA20 include N-Terminal Acetyltransferase Deficiency. Among its related pathways are Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and peptide alpha-N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAA20 Gene

  • Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.

Gene Wiki entry for NAA20 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA20 Gene

Genomics for NAA20 Gene

Regulatory Elements for NAA20 Gene

Enhancers for NAA20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F019913 1.7 FANTOM5 Ensembl ENCODE 11.2 -99.2 -99158 8.9 ATF1 MLX ARID4B YY1 FOS SP5 JUNB MXD4 TBX21 PPARG RIN2 NAA20 GC20P019952 ENSG00000275142
GH20F019902 1.6 FANTOM5 Ensembl ENCODE 10.4 -113.5 -113516 1.6 ATF1 ARID4B SIN3A SLC30A9 ZNF143 ZNF207 FOS JUNB PPARG KAT8 NAA20 ENSG00000232675 ENSG00000275142 GC20P019952
GH20F019782 1.5 FANTOM5 Ensembl ENCODE 10.7 -231.8 -231817 5.3 PKNOX1 ARID4B SIN3A ZNF2 ZNF143 ZNF207 FOS ZHX2 ZNF592 MBD2 LINC00652 ENSG00000232675 NAA20 RIN2 PIR61811 ENSG00000268628
GH20F019984 1.3 FANTOM5 Ensembl ENCODE 11 -31.1 -31074 2.7 SOX13 CTCF TFAP4 JUN ZNF644 YY1 KAT2B CREM MIXL1 NFIA RIN2 NAA20 GC20P019952
GH20F019963 1.3 Ensembl ENCODE 10.9 -52.4 -52372 1.8 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS SP5 NFYC NAA20 RIN2 RPL12P12 GC20P019952
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAA20 on UCSC Golden Path with GeneCards custom track

Promoters for NAA20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000008610 385 1800 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Location for NAA20 Gene

Chromosome:
20
Start:
20,017,116 bp from pter
End:
20,033,655 bp from pter
Size:
16,540 bases
Orientation:
Plus strand

Genomic View for NAA20 Gene

Genes around NAA20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA20 Gene

Proteins for NAA20 Gene

  • Protein details for NAA20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61599-NAA20_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 20
    Protein Accession:
    P61599
    Secondary Accessions:
    • A6NHA3
    • B2R4G4
    • Q5TFT7
    • Q9D7H8
    • Q9H0Y4
    • Q9NQH6
    • Q9Y6D2

    Protein attributes for NAA20 Gene

    Size:
    178 amino acids
    Molecular mass:
    20368 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.
    SequenceCaution:
    • Sequence=BG548527; Type=Frameshift; Positions=111; Evidence={ECO:0000305};

    Alternative splice isoforms for NAA20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA20 Gene

Post-translational modifications for NAA20 Gene

  • Ubiquitination at Lys 124
  • Modification sites at PhosphoSitePlus

Other Protein References for NAA20 Gene

No data available for DME Specific Peptides for NAA20 Gene

Domains & Families for NAA20 Gene

Protein Domains for NAA20 Gene

Suggested Antigen Peptide Sequences for NAA20 Gene

Graphical View of Domain Structure for InterPro Entry

P61599

UniProtKB/Swiss-Prot:

NAA20_HUMAN :
  • Contains 1 N-acetyltransferase domain.
  • Belongs to the acetyltransferase family. ARD1 subfamily.
Domain:
  • Contains 1 N-acetyltransferase domain.
Family:
  • Belongs to the acetyltransferase family. ARD1 subfamily.
genes like me logo Genes that share domains with NAA20: view

Function for NAA20 Gene

Molecular function for NAA20 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
UniProtKB/Swiss-Prot Function:
Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.

Enzyme Numbers (IUBMB) for NAA20 Gene

Gene Ontology (GO) - Molecular Function for NAA20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 peptide alpha-N-acetyltransferase activity IBA --
GO:0008080 N-acetyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with NAA20: view
genes like me logo Genes that share phenotypes with NAA20: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NAA20

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA20 Gene

Localization for NAA20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA20 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA20 gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for NAA20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0031416 NatB complex IBA --
genes like me logo Genes that share ontologies with NAA20: view

Pathways & Interactions for NAA20 Gene

genes like me logo Genes that share pathways with NAA20: view

Pathways by source for NAA20 Gene

1 BioSystems pathway for NAA20 Gene

Gene Ontology (GO) - Biological Process for NAA20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017196 N-terminal peptidyl-methionine acetylation IBA --
genes like me logo Genes that share ontologies with NAA20: view

No data available for SIGNOR curated interactions for NAA20 Gene

Drugs & Compounds for NAA20 Gene

(1) Drugs for NAA20 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for NAA20 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
genes like me logo Genes that share compounds with NAA20: view

Transcripts for NAA20 Gene

Unigene Clusters for NAA20 Gene

N(alpha)-acetyltransferase 20, NatB catalytic subunit:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA20 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -
SP3: - -
SP4:

Relevant External Links for NAA20 Gene

GeneLoc Exon Structure for
NAA20
ECgene alternative splicing isoforms for
NAA20

Expression for NAA20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAA20 Gene

Protein differential expression in normal tissues from HIPED for NAA20 Gene

This gene is overexpressed in Breast (21.8) and Peripheral blood mononuclear cells (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAA20 Gene



Protein tissue co-expression partners for NAA20 Gene

NURSA nuclear receptor signaling pathways regulating expression of NAA20 Gene:

NAA20

SOURCE GeneReport for Unigene cluster for NAA20 Gene:

Hs.368783
genes like me logo Genes that share expression patterns with NAA20: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAA20 Gene

Orthologs for NAA20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA20 34 35
  • 99.63 (n)
oppossum
(Monodelphis domestica)
Mammalia NAA20 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAA20 34 35
  • 91.76 (n)
dog
(Canis familiaris)
Mammalia NAA20 34 35
  • 91.39 (n)
rat
(Rattus norvegicus)
Mammalia Naa20 34
  • 91.2 (n)
mouse
(Mus musculus)
Mammalia Naa20 34 16 35
  • 91.01 (n)
chicken
(Gallus gallus)
Aves NAA20 34 35
  • 81.65 (n)
lizard
(Anolis carolinensis)
Reptilia NAA20 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia naa20 34
  • 81.65 (n)
MGC76078 34
zebrafish
(Danio rerio)
Actinopterygii naa20 34 35
  • 79.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14222 34 35
  • 68.02 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001878 34
  • 66.86 (n)
worm
(Caenorhabditis elegans)
Secernentea Y97E10AL.3 34 35
  • 60.31 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAT3 34 35 37
  • 52.68 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B11275g 34
  • 51.46 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR038C 34
  • 49.41 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G03150 34
  • 60.62 (n)
rice
(Oryza sativa)
Liliopsida Os03g0699400 34
  • 61.21 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 64 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU01276 34
  • 56.16 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes naa20 34
  • 55.56 (n)
Species where no ortholog for NAA20 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA20 Gene

ENSEMBL:
Gene Tree for NAA20 (if available)
TreeFam:
Gene Tree for NAA20 (if available)

Paralogs for NAA20 Gene

(1) SIMAP similar genes for NAA20 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for NAA20 Gene

genes like me logo Genes that share paralogs with NAA20: view

No data available for Paralogs for NAA20 Gene

Variants for NAA20 Gene

Sequence variations from dbSNP and Humsavar for NAA20 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs11087299 -- 20,018,437(+) TGTCA(G/T)GAAGA intron-variant
rs11087300 -- 20,021,051(+) GGGGG(-/GG)ACTTT intron-variant, upstream-variant-2KB
rs111717054 -- 20,017,189(+) AGCCA(C/T)AGCCC upstream-variant-2KB
rs111755160 -- 20,032,229(+) AATTT(A/G)TAGAA intron-variant
rs111803583 -- 20,020,365(+) CCTGG(A/G)GAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA20 Gene

Variant ID Type Subtype PubMed ID
nsv179610 CNV deletion 16902084
esv3645467 CNV loss 21293372
esv2665704 CNV deletion 23128226

Variation tolerance for NAA20 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAA20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA20 Gene

Disorders for NAA20 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NAA20 Gene - From: DISEASES

Disorder Aliases PubMed IDs
n-terminal acetyltransferase deficiency
  • ogden syndrome
- elite association - COSMIC cancer census association via MalaCards
Search NAA20 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NAA20

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAA20
genes like me logo Genes that share disorders with NAA20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAA20 Gene

Publications for NAA20 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B. … Sherman F. (BMC Proc. 2009) 2 3 4 64
  2. Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression. (PMID: 18570629) Starheim K.K. … Lillehaug J.R. (Biochem. J. 2008) 2 3 4 64
  3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 2 3 64
  4. Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation. (PMID: 19716809) Kuo H.P. … Hung M.C. (Biochem. Biophys. Res. Commun. 2009) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for NAA20 Gene

Sources for NAA20 Gene

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