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Aliases for NAA20 Gene

Aliases for NAA20 Gene

  • N(Alpha)-Acetyltransferase 20, NatB Catalytic Subunit 2 3
  • NAT5 3 4 6
  • N-Acetyltransferase 5, ARD1 Subunit (Arrest-Defective 1, S. Cerevisiae, Homolog) 2 3
  • N-Terminal Acetyltransferase B Complex Catalytic Subunit NAA20 3 4
  • N-Terminal Acetyltransferase B Complex Catalytic Subunit NAT5 3 4
  • N-Acetyltransferase 5 (ARD1 Homolog, S. Cerevisiae) 2 3
  • N-Acetyltransferase 5 (GCN5-Related, Putative) 2 3
  • Methionine N-Acetyltransferase 3 4
  • NatB Complex Subunit NAT5 3 4
  • NatB Catalytic Subunit 3 4
  • N-Acetyltransferase 5 2 4
  • NAT3 3 6
  • N-Alpha-Acetyltransferase 20, NatB Catalytic Subunit 3
  • N-Terminal Acetyltransferase Complex ARD1 Subunit 3
  • N-Acetyltransferase 3 Homolog (S. Cerevisiae) 2
  • N-Acetyltransferase 3 Homolog 3
  • N-Alpha-Acetyltransferase 20 3
  • EC 2.3.1.88 4
  • DJ1002M8.1 3
  • NAT5P 3
  • NAT3P 3

External Ids for NAA20 Gene

Previous HGNC Symbols for NAA20 Gene

  • NAT5

Summaries for NAA20 Gene

Entrez Gene Summary for NAA20 Gene

  • NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 [PubMed 18570629]).[supplied by OMIM, Apr 2009]

GeneCards Summary for NAA20 Gene

NAA20 (N(Alpha)-Acetyltransferase 20, NatB Catalytic Subunit) is a Protein Coding gene. Diseases associated with NAA20 include eastern equine encephalitis. Among its related pathways are Biological oxidations. GO annotations related to this gene include peptide alpha-N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAA20 Gene

  • Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.

Gene Wiki entry for NAA20 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA20 Gene

Genomics for NAA20 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NAA20 Gene

Start:
20,017,116 bp from pter
End:
20,033,655 bp from pter
Size:
16,540 bases
Orientation:
Plus strand

Genomic View for NAA20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAA20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA20 Gene

No data available for Regulatory Elements for NAA20 Gene

Proteins for NAA20 Gene

  • Protein details for NAA20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61599-NAA20_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 20
    Protein Accession:
    P61599
    Secondary Accessions:
    • A6NHA3
    • B2R4G4
    • Q5TFT7
    • Q9D7H8
    • Q9H0Y4
    • Q9NQH6
    • Q9Y6D2

    Protein attributes for NAA20 Gene

    Size:
    178 amino acids
    Molecular mass:
    20368 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25
    SequenceCaution:
    • Sequence=BG548527; Type=Frameshift; Positions=111; Evidence={ECO:0000305};

    Alternative splice isoforms for NAA20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA20 Gene

Proteomics data for NAA20 Gene at MOPED

Post-translational modifications for NAA20 Gene

  • Ubiquitination at Lys124
  • Modification sites at PhosphoSitePlus

Other Protein References for NAA20 Gene

No data available for DME Specific Peptides for NAA20 Gene

Domains for NAA20 Gene

Gene Families for NAA20 Gene

HGNC:
  • NAA :N(alpha)-acetyltransferase subunits

Protein Domains for NAA20 Gene

Suggested Antigen Peptide Sequences for NAA20 Gene

Graphical View of Domain Structure for InterPro Entry

P61599

UniProtKB/Swiss-Prot:

NAA20_HUMAN :
  • P61599
Domain:
  • Contains 1 N-acetyltransferase domain.
Family:
  • Belongs to the acetyltransferase family. ARD1 subfamily.
genes like me logo Genes that share domains with NAA20: view

Function for NAA20 Gene

Molecular function for NAA20 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA
UniProtKB/Swiss-Prot Function: Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.

Enzyme Numbers (IUBMB) for NAA20 Gene

Gene Ontology (GO) - Molecular Function for NAA20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 peptide alpha-N-acetyltransferase activity IBA --
GO:0008080 N-acetyltransferase activity --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
genes like me logo Genes that share ontologies with NAA20: view

Animal Model Products

CRISPR Products

miRNA for NAA20 Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NAA20 Gene

Localization for NAA20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA20 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAA20 Gene COMPARTMENTS Subcellular localization image for NAA20 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for NAA20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0031416 NatB complex IBA --
genes like me logo Genes that share ontologies with NAA20: view

Pathways for NAA20 Gene

SuperPathways for NAA20 Gene

Superpath Contained pathways
1 Biological oxidations
genes like me logo Genes that share pathways with NAA20: view

Pathways by source for NAA20 Gene

1 BioSystems pathway for NAA20 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat

Gene Ontology (GO) - Biological Process for NAA20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0017196 N-terminal peptidyl-methionine acetylation IBA --
genes like me logo Genes that share ontologies with NAA20: view

Transcripts for NAA20 Gene

Unigene Clusters for NAA20 Gene

N(alpha)-acetyltransferase 20, NatB catalytic subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAA20

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA20 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -
SP3: - -
SP4:

Relevant External Links for NAA20 Gene

GeneLoc Exon Structure for
NAA20
ECgene alternative splicing isoforms for
NAA20

Expression for NAA20 Gene

mRNA expression in normal human tissues for NAA20 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAA20 Gene

SOURCE GeneReport for Unigene cluster for NAA20 Gene Hs.368783

genes like me logo Genes that share expressions with NAA20: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAA20 Gene

Orthologs for NAA20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA20 35
  • 99.63 (n)
  • 100 (a)
NAA20 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAA20 35
  • 91.76 (n)
  • 100 (a)
NAA20 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAA20 35
  • 91.39 (n)
  • 95.51 (a)
NAA20 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Naa20 35
  • 91.01 (n)
  • 99.44 (a)
Naa20 16
Naa20 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAA20 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Naa20 35
  • 91.2 (n)
  • 99.44 (a)
chicken
(Gallus gallus)
Aves NAA20 35
  • 81.65 (n)
  • 98.31 (a)
NAA20 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAA20 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76078 35
naa20 35
  • 81.65 (n)
  • 98.31 (a)
zebrafish
(Danio rerio)
Actinopterygii naa20 35
  • 79.59 (n)
  • 98.88 (a)
naa20 36
  • 99 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001878 35
  • 66.86 (n)
  • 72.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14222 35
  • 68.02 (n)
  • 71.1 (a)
CG14222 36
  • 66 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y97E10AL.3 35
  • 60.31 (n)
  • 61.85 (a)
Y97E10AL.3 36
  • 62 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR038C 35
  • 49.41 (n)
  • 47.65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAT3 35
  • 52.68 (n)
  • 48.28 (a)
NAT3 36
  • 43 (a)
OneToOne
NAT3 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B11275g 35
  • 51.46 (n)
  • 43.75 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G03150 35
  • 60.62 (n)
  • 61.4 (a)
rice
(Oryza sativa)
Liliopsida Os03g0699400 35
  • 61.21 (n)
  • 62.57 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01276 35
  • 56.16 (n)
  • 51.52 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes naa20 35
  • 55.56 (n)
  • 59.88 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToOne
Species with no ortholog for NAA20:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA20 Gene

ENSEMBL:
Gene Tree for NAA20 (if available)
TreeFam:
Gene Tree for NAA20 (if available)

Paralogs for NAA20 Gene

Selected SIMAP similar genes for NAA20 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for NAA20 Gene

genes like me logo Genes that share paralogs with NAA20: view

No data available for Paralogs for NAA20 Gene

Variants for NAA20 Gene

Sequence variations from dbSNP and Humsavar for NAA20 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs7263 -- 20,025,724(+) GAGTA(C/T)TTCAT synonymous-codon, reference
rs199539 -- 20,016,068(+) tcttg(C/G)tgtgt upstream-variant-2KB
rs200174 -- 20,019,338(+) AGAGA(C/T)GATGA intron-variant
rs200175 -- 20,020,839(+) aagag(G/T)agctg intron-variant
rs200176 -- 20,023,942(+) AAATA(A/G)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA20 Gene

Variant ID Type Subtype PubMed ID
esv2665704 CNV Deletion 23128226
nsv179610 CNV Loss 16902084

Relevant External Links for NAA20 Gene

HapMap Linkage Disequilibrium report
NAA20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA20 Gene

Disorders for NAA20 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NAA20 Gene including...

Search for NAA20 Gene in MalaCards »

(1) University of Copenhagen DISEASES for NAA20 Gene

genes like me logo Genes that share disorders with NAA20: view

No data available for UniProtKB/Swiss-Prot for NAA20 Gene

Publications for NAA20 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B. … Sherman F. (BMC Proc. 2009) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression. (PMID: 18570629) Starheim K.K. … Lillehaug J.R. (Biochem. J. 2008) 3 4
  4. Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation. (PMID: 19716809) Kuo H.P. … Hung M.C. (Biochem. Biophys. Res. Commun. 2009) 3 23
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for NAA20 Gene

Sources for NAA20 Gene

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