NAA16 Gene
protein-coding GIFtS: 46
GCID: GC13P041885
|
|
N(alpha)-acetyltransferase 16, NatA auxiliary subunit(Previous name: NMDA receptor regulated 1-like )
(Previous symbol: NARG1L)
| |
Aliases
for NAA16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| N(Alpha)-Acetyltransferase 16, NatA Auxiliary Subunit1 2 | | MGC406121 | | NARG1L1 2 3 | | PRO24351 | | NARG1-Like Protein2 3 | | NMDA Receptor Regulated 1-Like1 | | NMDA Receptor-Regulated 1-Like Protein2 3 | | N-Alpha-Acetyltransferase 16, NatA Auxiliary Subunit2 | | FLJ220541 | | NAT23 |
Export aliases for NAA16 gene to outside databasesPrevious GC identifer: GC13P022684 |
Summaries
for NAA16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NAA16_HUMAN, Q6N069Function: May belong to a complex displaying N-terminal acetyltransferase activity (By similarity)
|
Genomic Views
for NAA16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for NAA16
Other transcription factors
Search SABiosciences Chromatin IP Primers for NAA16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAA16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14.11 Ensembl cytogenetic band: 13q14.11 HGNC cytogenetic band: 13q14.11NAA16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P041885: view genomic region
(about GC identifiers)
Start:
|
41,885,341 bp from pter |
End:
|
41,951,166 bp from pter |
Size:
|
65,826 bases |
Orientation:
|
plus strand |
|
Proteins
for NAA16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NAA16_HUMAN, Q6N069 (See
protein sequence)Recommended Name: N-alpha-acetyltransferase 16, NatA auxiliary subunit Size: 864 amino acids; 101462 Da
Secondary accessions: B0QZ59 Q5VSP9 Q6P2D5 Q8N5J3 Q8N870Alternative splicing: 5 isoforms: Q6N069-1 Q6N069-2 Q6N069-3 Q6N069-4 Q6N069-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NAA16: NX_Q6N069
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6N069
NAA16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001104268.1 NP_060997.2 NP_078837.3
ENSEMBL proteins: ENSP00000368716 ENSP00000386103 ENSP00000432364 ENSP00000368674
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NAA16 for ontologies About GeneDecksing
NAA16 Antibody Products:
Assay Products for NAA16: |
Protein
Domains /
Families
for NAA16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NAA16 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6N069ProtoNet protein and cluster: Q6N069 UniProtKB/Swiss-Prot: NAA16_HUMAN, Q6N069Similarity: Contains 7 TPR repeats |
Function
for NAA16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NAA16_HUMAN, Q6N069Function: May belong to a complex displaying N-terminal acetyltransferase activity (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAA16 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAA16 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for NAA16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAA16 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA16 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016407 | contributes to acetyltransferase activity |
ISS | -- | | GO:0043022 | contributes to ribosome binding |
ISS | -- |
NAA16 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NAA16:
|
Pathways & Interactions
for NAA16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAA16
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/106 Interacting proteins for NAA16 (Q6N0693 ENSP000003687164) via UniProtKB, MINT, STRING, and/or I2D (see all 106)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006474 | N-terminal protein amino acid acetylation |
ISS | -- | | GO:0045893 | positive regulation of transcription, DNA-dependent |
ISS | -- |
NAA16 for ontologies About GeneDecksing
|
Drugs & Compounds
for NAA16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NAA16
Search CenterWatch for drugs/clinical trials and news about NAA16
|
Transcripts
for NAA16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NAA16 gene (3 alternative transcripts): NM_001110798.1 NM_018527.3 NM_024561.4 Unigene Cluster for NAA16: N(alpha)-acetyltransferase 16, NatA auxiliary subunit Hs.512914 [show with all ESTs]Unigene Representative Sequence: CR62732712 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000379406(uc001uyf.2 uc010tfg.1) ENST00000403412(uc001uye.4 uc001uyd.4)
ENST00000476980 ENST00000464857 ENST00000483215 ENST00000497727 ENST00000463114
ENST00000497143 ENST00000495148 ENST00000477452 ENST00000469708 ENST00000379367
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAA16 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAA16 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): NAA16 (NM_024561) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NAA16 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAA16 |
Additional cDNA sequence: AK025707.1 AK291248.1 AL833341.1 BC017099.1 BC028112.1 BC032318.1 BC064592.1 BC101719.1 BC101721.1 BC131581.1 BC143506.1 CR627327.1 11 DOTS entries: DT.429879 DT.102826114 DT.75183263 DT.101976975 DT.91643798 DT.100014235 DT.208091 DT.120781342 DT.91918139 DT.95236875 DT.97786033 24/71 AceView cDNA sequences (see all 71): F12400 NM_024561 AV659285 BC032318 BC017099 AA659554 AK097224 AW779504 AI768620 BC064592 NM_018527 W79572 CD300578 BX282564 AA076277 BG492997 AW614604 BG777139 H58260 BF222959 BQ787698 AK025707 AI376437 BI858089
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NAA16 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NAA16
|
Expression
for NAA16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NAA16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCAGAACCT
About this image
See NAA16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NAA16
SOURCE GeneReport for Unigene cluster: Hs.512914
SABiosciences Custom PCR Arrays for NAA16
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAA16
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA16 |
Orthologs
for NAA16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NAA16 gene from 6/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NAA161 |
N(alpha)-acetyltransferase 16, NatA auxiliary subunit |
84.26(n)
89(a) |
|
418832 XM_417028.3 XP_417028.2 |
lizard
(Anolis carolinensis) |
Reptilia |
NAA166 |
-- |
88(a) |
1 ↔ 1 |
3(70585896-70631160) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Nat16 |
Nat1 |
51(a) |
1 → many |
X(19374186-19378676) |
worm
(Caenorhabditis elegans) |
Secernentea |
hpo-296 |
Protein HPO-29 |
40(a) |
1 → many |
III(235841-253375) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
EMB27536 |
tetratricopeptide repeat-containing protein |
38(a) |
1 → many |
1(30227485-30234985) |
rice
(Oryza sativa) |
Liliopsida |
Os.114662 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
74.37(n) |
|
AK065278.1 |
ENSEMBL Gene Tree for NAA16 (if available)
TreeFam Gene Tree for NAA16 (if available) |
Paralogs
for NAA16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NAA16 gene
- NAA152
3 SIMAP similar genes for NAA16 using alignment to 1 protein entry: NAA16_HUMAN:NARG1L NARG1 NAA15
NAA16 for paralogs About GeneDecksing
|
Genomic Variants
for NAA16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NAA16 (41885341 - 41951166 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for NAA16
2 CNVs: 101713 101712
2 Indels: 45165 41414 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAA16 |
|
Disorders
/ Diseases
for NAA16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NAA16 for disorders About GeneDecksing
1  disease for NAA16: About MalaCardsmalaria
Export disorders for NAA16 gene to outside databases
|
Publications
for NAA16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NAA16 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with NAA16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PubMed id 19660095)1, 2, 3 Polevoda B.... Sherman F. (2009)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PubMed id 11483580)1, 3 Yu Y....He F. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
|
External Searches for NAA16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NAA16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NAA16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAA16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NAA16 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NAA16 gene:
Search GeneIP for patents involving NAA16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NAA16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 |
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 | | | NAA16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA16 |
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