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Aliases for NAA16 Gene

Aliases for NAA16 Gene

  • N(Alpha)-Acetyltransferase 16, NatA Auxiliary Subunit 2 3
  • NMDA Receptor-Regulated 1-Like Protein 3 4
  • NARG1-Like Protein 3 4
  • NARG1L 3 4
  • N-Alpha-Acetyltransferase 16, NatA Auxiliary Subunit 3
  • NMDA Receptor Regulated 1-Like 2
  • NAT2 4

External Ids for NAA16 Gene

Previous HGNC Symbols for NAA16 Gene

  • NARG1L

Previous GeneCards Identifiers for NAA16 Gene

  • GC13P041885
  • GC13P022684

Summaries for NAA16 Gene

GeneCards Summary for NAA16 Gene

NAA16 (N(Alpha)-Acetyltransferase 16, NatA Auxiliary Subunit) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include ribosome binding and acetyltransferase activity. An important paralog of this gene is NAA15.

UniProtKB/Swiss-Prot for NAA16 Gene

  • Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA16 Gene

Genomics for NAA16 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NAA16 Gene

41,311,205 bp from pter
41,377,030 bp from pter
65,826 bases
Plus strand

Genomic View for NAA16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAA16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA16 Gene

No data available for Regulatory Elements for NAA16 Gene

Proteins for NAA16 Gene

  • Protein details for NAA16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N-alpha-acetyltransferase 16, NatA auxiliary subunit
    Protein Accession:
    Secondary Accessions:
    • B0QZ59
    • Q5VSP9
    • Q6P2D5
    • Q8N5J3
    • Q8N870

    Protein attributes for NAA16 Gene

    864 amino acids
    Molecular mass:
    101462 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 and NAA16

    Alternative splice isoforms for NAA16 Gene


neXtProt entry for NAA16 Gene

Proteomics data for NAA16 Gene at MOPED

Post-translational modifications for NAA16 Gene

  • Ubiquitination at Lys52
  • Modification sites at PhosphoSitePlus

Other Protein References for NAA16 Gene

Antibody Products

No data available for DME Specific Peptides for NAA16 Gene

Domains for NAA16 Gene

Protein Domains for NAA16 Gene

Suggested Antigen Peptide Sequences for NAA16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 7 TPR repeats.
  • Contains 7 TPR repeats.
genes like me logo Genes that share domains with NAA16: view

Function for NAA16 Gene

Molecular function for NAA16 Gene

UniProtKB/Swiss-Prot Function:
Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity

Gene Ontology (GO) - Molecular Function for NAA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 contributes_to peptide alpha-N-acetyltransferase activity IDA 19480662
GO:0005515 protein binding IPI 19480662
GO:0016407 contributes_to acetyltransferase activity ISS --
GO:0043022 contributes_to ribosome binding ISS --
genes like me logo Genes that share ontologies with NAA16: view

Phenotypes for NAA16 Gene

GenomeRNAi human phenotypes for NAA16:
genes like me logo Genes that share phenotypes with NAA16: view

Animal Model Products

miRNA for NAA16 Gene

miRTarBase miRNAs that target NAA16

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA16 Gene

Localization for NAA16 Gene

Subcellular locations from

Jensen Localization Image for NAA16 Gene COMPARTMENTS Subcellular localization image for NAA16 gene
Compartment Confidence
cytosol 4
nucleus 4
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NAA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005667 transcription factor complex ISS --
GO:0005737 cytoplasm ISS --
GO:0031415 NatA complex IDA 19480662
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NAA16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NAA16 Gene

Pathways for NAA16 Gene

genes like me logo Genes that share pathways with NAA16: view

Gene Ontology (GO) - Biological Process for NAA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006474 N-terminal protein amino acid acetylation ISS --
GO:0043066 negative regulation of apoptotic process IMP 19480662
GO:0045893 positive regulation of transcription, DNA-templated ISS --
GO:0050821 protein stabilization IMP 19480662
genes like me logo Genes that share ontologies with NAA16: view

Transcripts for NAA16 Gene

Unigene Clusters for NAA16 Gene

N(alpha)-acetyltransferase 16, NatA auxiliary subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAA16 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b · 14c
SP1: -
SP6: - -
SP7: -

Relevant External Links for NAA16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAA16 Gene

mRNA expression in normal human tissues for NAA16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for NAA16 Gene

This gene is overexpressed in Lymph node (21.3), Plasma (13.4), Heart (8.6), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAA16 Gene

SOURCE GeneReport for Unigene cluster for NAA16 Gene Hs.512914

genes like me logo Genes that share expressions with NAA16: view

Expression partners for NAA16 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAA16 Gene

Orthologs for NAA16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA16 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia NAA16 35
  • 94.09 (n)
  • 96.45 (a)
NAA16 36
  • 96 (a)
(Mus musculus)
Mammalia Naa16 35
  • 87.58 (n)
  • 88.19 (a)
Naa16 16
Naa16 36
  • 88 (a)
(Pan troglodytes)
Mammalia NAA16 35
  • 99.54 (n)
  • 99.54 (a)
NAA16 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Naa16 35
  • 88.12 (n)
  • 88.77 (a)
(Bos Taurus)
Mammalia NAA16 36
  • 93 (a)
(Monodelphis domestica)
Mammalia NAA16 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia NAA16 36
  • 88 (a)
(Gallus gallus)
Aves NAA16 35
  • 84.26 (n)
  • 89 (a)
NAA16 36
  • 89 (a)
(Anolis carolinensis)
Reptilia NAA16 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia naa16 35
  • 76.16 (n)
  • 82.29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002284 35
  • 54.98 (n)
  • 57.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nat1 35
  • 53.89 (n)
  • 54.66 (a)
Nat1 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea hpo-29 35
  • 51.53 (n)
  • 41.76 (a)
hpo-29 36
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAT1 36
  • 29 (a)
NAT1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB2753 35
  • 53.35 (n)
  • 45.17 (a)
(Oryza sativa)
Liliopsida Os.11466 35
Os01g0617500 35
  • 52.52 (n)
  • 43.91 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5282 35
bread mold
(Neurospora crassa)
Ascomycetes NCU11379 35
  • 45.46 (n)
  • 39.26 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes naa15 35
  • 49.62 (n)
  • 41.22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10581 36
  • 49 (a)
Species with no ortholog for NAA16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NAA16 Gene

Gene Tree for NAA16 (if available)
Gene Tree for NAA16 (if available)

Paralogs for NAA16 Gene

Paralogs for NAA16 Gene

(3) SIMAP similar genes for NAA16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NAA16: view

Variants for NAA16 Gene

Sequence variations from dbSNP and Humsavar for NAA16 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs3355 -- 41,376,877(-) TTTGT(C/G)TTAAT utr-variant-3-prime
rs1572017 -- 41,312,144(-) CAAAC(C/T)TTTTC intron-variant
rs2026467 -- 41,314,272(-) TAATA(A/C)TCATA intron-variant
rs2065498 -- 41,318,969(-) ATTTA(A/C)TTTGA intron-variant
rs2483096 -- 41,310,434(+) CGGAG(G/T)TTGAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NAA16 Gene

Variant ID Type Subtype PubMed ID
esv2498442 CNV Insertion 19546169
esv269506 CNV Insertion 20981092
esv2494010 CNV Deletion 19546169
esv2747303 CNV Deletion 23290073
esv2073591 CNV Deletion 18987734
esv4789 CNV Deletion 18987735
esv1009722 CNV Deletion 20482838
esv1370240 CNV Deletion 17803354

Relevant External Links for NAA16 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA16 Gene

Disorders for NAA16 Gene

No disorders were found for NAA16 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for NAA16 Gene

Publications for NAA16 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B. … Sherman F. (BMC Proc. 2009) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1). (PMID: 19480662) Arnesen T. … Lillehaug J.R. (BMC Biochem. 2009) 3 4

Products for NAA16 Gene

Sources for NAA16 Gene

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