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Aliases for NAA16 Gene

Aliases for NAA16 Gene

  • N(Alpha)-Acetyltransferase 16, NatA Auxiliary Subunit 2 3 5
  • NMDA Receptor-Regulated 1-Like Protein 3 4
  • NARG1-Like Protein 3 4
  • NARG1L 3 4
  • N-Alpha-Acetyltransferase 16, NatA Auxiliary Subunit 3
  • NMDA Receptor Regulated 1-Like 2
  • NAT2 4

External Ids for NAA16 Gene

Previous HGNC Symbols for NAA16 Gene

  • NARG1L

Previous GeneCards Identifiers for NAA16 Gene

  • GC13P041885
  • GC13P022684

Summaries for NAA16 Gene

GeneCards Summary for NAA16 Gene

NAA16 (N(Alpha)-Acetyltransferase 16, NatA Auxiliary Subunit) is a Protein Coding gene. GO annotations related to this gene include ribosome binding and peptide alpha-N-acetyltransferase activity. An important paralog of this gene is NAA15.

UniProtKB/Swiss-Prot for NAA16 Gene

  • Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity.

Additional gene information for NAA16 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA16 Gene

Genomics for NAA16 Gene

Regulatory Elements for NAA16 Gene

Enhancers for NAA16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H041056 1.7 Ensembl ENCODE dbSUPER 28.9 -249.9 -249913 9.7 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZNF610 ZNF585B GLIS1 NAA16 WBP4 TPTE2P5 LINC00548 MTRF1 RNU6-57P CYCSP34 ELF1
GH13H041284 1.1 Ensembl ENCODE 34.2 -25.6 -25577 2.3 TBP PKNOX1 FOXA2 NFIB SIN3A RARA GTF3C2 POLR3A FOS CEBPB NAA16 MTRF1 RAC1P3
GH13H040661 1.6 Ensembl ENCODE dbSUPER 20.4 -646.2 -646190 7.2 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 ZNF143 ZNF207 FOS SP3 NAA16 LINC00548 TPTE2P5 CYCSP34 SLC25A15 FOXO1 PIR36841
GH13H042270 1.7 FANTOM5 Ensembl ENCODE 17.7 +962.6 962572 6.4 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 AKAP11 NAA16 TNFSF11 DGKH GC13M042285
GH13H041310 1.1 ENCODE 22.9 +1.1 1064 3.5 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 FOS ZNF548 NAA16 MTRF1 RNU6-57P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAA16 on UCSC Golden Path with GeneCards custom track

Promoters for NAA16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000061781 795 2801 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 FOS ZHX2

Genomic Locations for NAA16 Gene

Genomic Locations for NAA16 Gene
chr13:41,311,205-41,377,030
(GRCh38/hg38)
Size:
65,826 bases
Orientation:
Plus strand
chr13:41,885,341-41,951,166
(GRCh37/hg19)

Genomic View for NAA16 Gene

Genes around NAA16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA16 Gene

Proteins for NAA16 Gene

  • Protein details for NAA16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6N069-NAA16_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 16, NatA auxiliary subunit
    Protein Accession:
    Q6N069
    Secondary Accessions:
    • B0QZ59
    • Q5VSP9
    • Q6P2D5
    • Q8N5J3
    • Q8N870

    Protein attributes for NAA16 Gene

    Size:
    864 amino acids
    Molecular mass:
    101462 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 and NAA16.

    Alternative splice isoforms for NAA16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA16 Gene

Post-translational modifications for NAA16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAA16 Gene

Domains & Families for NAA16 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NAA16: view

No data available for UniProtKB/Swiss-Prot for NAA16 Gene

Function for NAA16 Gene

Molecular function for NAA16 Gene

UniProtKB/Swiss-Prot Function:
Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity.

Phenotypes From GWAS Catalog for NAA16 Gene

Gene Ontology (GO) - Molecular Function for NAA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 contributes_to peptide alpha-N-acetyltransferase activity IDA 19480662
GO:0005515 protein binding IPI 19480662
GO:0016407 contributes_to acetyltransferase activity ISS --
GO:0043022 contributes_to ribosome binding ISS --
genes like me logo Genes that share ontologies with NAA16: view
genes like me logo Genes that share phenotypes with NAA16: view

Animal Model Products

miRNA for NAA16 Gene

miRTarBase miRNAs that target NAA16

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA16 Gene

Localization for NAA16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA16 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005667 transcription factor complex ISS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol IDA --
GO:0031415 NatA complex IDA 19480662
genes like me logo Genes that share ontologies with NAA16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NAA16 Gene

Pathways & Interactions for NAA16 Gene

SuperPathways for NAA16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006474 N-terminal protein amino acid acetylation ISS --
GO:0017196 N-terminal peptidyl-methionine acetylation IBA --
GO:0043066 negative regulation of apoptotic process IMP 19480662
GO:0045893 positive regulation of transcription, DNA-templated ISS --
GO:0050821 protein stabilization IMP 19480662
genes like me logo Genes that share ontologies with NAA16: view

No data available for Pathways by source and SIGNOR curated interactions for NAA16 Gene

Drugs & Compounds for NAA16 Gene

No Compound Related Data Available

Transcripts for NAA16 Gene

mRNA/cDNA for NAA16 Gene

(10) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NAA16 Gene

N(alpha)-acetyltransferase 16, NatA auxiliary subunit:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA16 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b · 14c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7: -
SP8:

Relevant External Links for NAA16 Gene

GeneLoc Exon Structure for
NAA16
ECgene alternative splicing isoforms for
NAA16

Expression for NAA16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAA16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAA16 Gene

This gene is overexpressed in Lymph node (21.3), Plasma (13.4), Heart (8.6), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAA16 Gene



Protein tissue co-expression partners for NAA16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAA16 Gene:

NAA16

SOURCE GeneReport for Unigene cluster for NAA16 Gene:

Hs.512914

Evidence on tissue expression from TISSUES for NAA16 Gene

  • Intestine(4.2)
  • Pancreas(4.2)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with NAA16: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA16 Gene

Orthologs for NAA16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA16 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia NAA16 33 34
  • 94.09 (n)
cow
(Bos Taurus)
Mammalia NAA16 34
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAA16 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Naa16 33
  • 88.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NAA16 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Naa16 33 16 34
  • 87.58 (n)
chicken
(Gallus gallus)
Aves NAA16 33 34
  • 84.26 (n)
lizard
(Anolis carolinensis)
Reptilia NAA16 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia naa16 33
  • 76.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002284 33
  • 54.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nat1 33 34
  • 53.89 (n)
worm
(Caenorhabditis elegans)
Secernentea hpo-29 33 34
  • 51.53 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAT1 34 36
  • 29 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB2753 33
  • 53.35 (n)
rice
(Oryza sativa)
Liliopsida Os01g0617500 33
  • 52.52 (n)
Os.11466 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes naa15 33
  • 49.62 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10581 34
  • 49 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU11379 33
  • 45.46 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5282 33
Species where no ortholog for NAA16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NAA16 Gene

ENSEMBL:
Gene Tree for NAA16 (if available)
TreeFam:
Gene Tree for NAA16 (if available)

Paralogs for NAA16 Gene

Paralogs for NAA16 Gene

(3) SIMAP similar genes for NAA16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NAA16: view

Variants for NAA16 Gene

Sequence variations from dbSNP and Humsavar for NAA16 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000027487 -- 41,349,193(+) TTTAA(A/G)TCTTT intron-variant
rs1000059218 -- 41,326,428(+) TCCAT(A/C/G)CAATT intron-variant
rs1000075493 -- 41,345,268(+) AGACT(A/C)TTTTT intron-variant
rs1000104628 -- 41,332,891(+) TTTCA(A/G)TTCCA intron-variant
rs1000136118 -- 41,345,860(+) TGAGC(A/C)AGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA16 Gene

Variant ID Type Subtype PubMed ID
nsv957451 CNV deletion 24416366
esv4789 CNV loss 18987735
esv3322672 CNV insertion 20981092
esv3305228 CNV mobile element insertion 20981092
esv2747303 CNV deletion 23290073
esv2498442 CNV insertion 19546169
esv2494010 CNV deletion 19546169
esv2073591 CNV deletion 18987734
esv1370240 CNV deletion 17803354
esv1009722 CNV deletion 20482838

Variation tolerance for NAA16 Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAA16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA16 Gene

Disorders for NAA16 Gene

Relevant External Links for NAA16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAA16

No disorders were found for NAA16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA16 Gene

Publications for NAA16 Gene

  1. A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1). (PMID: 19480662) Arnesen T … Lillehaug JR (BMC biochemistry 2009) 2 3 4 60
  2. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B … Sherman F (BMC proceedings 2009) 2 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for NAA16 Gene

Sources for NAA16 Gene

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