Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NAA16 Gene

Aliases for NAA16 Gene

  • N(Alpha)-Acetyltransferase 16, NatA Auxiliary Subunit 2 3 5
  • NMDA Receptor-Regulated 1-Like Protein 3 4
  • NARG1-Like Protein 3 4
  • NARG1L 3 4
  • NMDA Receptor Regulated 1-Like 2
  • NAT2 4

External Ids for NAA16 Gene

Previous HGNC Symbols for NAA16 Gene

  • NARG1L

Previous GeneCards Identifiers for NAA16 Gene

  • GC13P041885
  • GC13P022684

Summaries for NAA16 Gene

GeneCards Summary for NAA16 Gene

NAA16 (N(Alpha)-Acetyltransferase 16, NatA Auxiliary Subunit) is a Protein Coding gene. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include ribosome binding and peptide alpha-N-acetyltransferase activity. An important paralog of this gene is NAA15.

UniProtKB/Swiss-Prot for NAA16 Gene

  • Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA16 Gene

Genomics for NAA16 Gene

Regulatory Elements for NAA16 Gene

Promoters for NAA16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NAA16 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAA16 Gene

Chromosome:
13
Start:
41,311,205 bp from pter
End:
41,377,030 bp from pter
Size:
65,826 bases
Orientation:
Plus strand

Genomic View for NAA16 Gene

Genes around NAA16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA16 Gene

Proteins for NAA16 Gene

  • Protein details for NAA16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6N069-NAA16_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 16, NatA auxiliary subunit
    Protein Accession:
    Q6N069
    Secondary Accessions:
    • B0QZ59
    • Q5VSP9
    • Q6P2D5
    • Q8N5J3
    • Q8N870

    Protein attributes for NAA16 Gene

    Size:
    864 amino acids
    Molecular mass:
    101462 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 and NAA16.

    Alternative splice isoforms for NAA16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA16 Gene

Proteomics data for NAA16 Gene at MOPED

Post-translational modifications for NAA16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAA16 Gene

No data available for DME Specific Peptides for NAA16 Gene

Domains & Families for NAA16 Gene

Protein Domains for NAA16 Gene

Graphical View of Domain Structure for InterPro Entry

Q6N069

UniProtKB/Swiss-Prot:

NAA16_HUMAN :
  • Contains 7 TPR repeats.
Similarity:
  • Contains 7 TPR repeats.
genes like me logo Genes that share domains with NAA16: view

Function for NAA16 Gene

Molecular function for NAA16 Gene

UniProtKB/Swiss-Prot Function:
Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity.

Gene Ontology (GO) - Molecular Function for NAA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016407 contributes_to acetyltransferase activity ISS --
genes like me logo Genes that share ontologies with NAA16: view
genes like me logo Genes that share phenotypes with NAA16: view

Animal Model Products

miRNA for NAA16 Gene

miRTarBase miRNAs that target NAA16

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA16 Gene

Localization for NAA16 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAA16 Gene COMPARTMENTS Subcellular localization image for NAA16 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NAA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0031415 NatA complex IDA 19480662
genes like me logo Genes that share ontologies with NAA16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NAA16 Gene

Pathways & Interactions for NAA16 Gene

genes like me logo Genes that share pathways with NAA16: view

Gene Ontology (GO) - Biological Process for NAA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045893 positive regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with NAA16: view

No data available for SIGNOR curated interactions for NAA16 Gene

Drugs & Compounds for NAA16 Gene

No Compound Related Data Available

Transcripts for NAA16 Gene

Unigene Clusters for NAA16 Gene

N(alpha)-acetyltransferase 16, NatA auxiliary subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAA16 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b · 14c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7: -
SP8:

Relevant External Links for NAA16 Gene

GeneLoc Exon Structure for
NAA16
ECgene alternative splicing isoforms for
NAA16

Expression for NAA16 Gene

mRNA expression in normal human tissues for NAA16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAA16 Gene

This gene is overexpressed in Lymph node (21.3), Plasma (13.4), Heart (8.6), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAA16 Gene



SOURCE GeneReport for Unigene cluster for NAA16 Gene Hs.512914

genes like me logo Genes that share expression patterns with NAA16: view

Protein tissue co-expression partners for NAA16 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAA16 Gene

Orthologs for NAA16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA16 36
  • 100 (a)
OneToOne
NAA16 35
  • 99.54 (n)
  • 99.54 (a)
cow
(Bos Taurus)
Mammalia NAA16 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAA16 36
  • 96 (a)
OneToOne
NAA16 35
  • 94.09 (n)
  • 96.45 (a)
mouse
(Mus musculus)
Mammalia Naa16 16
Naa16 36
  • 88 (a)
OneToOne
Naa16 35
  • 87.58 (n)
  • 88.19 (a)
oppossum
(Monodelphis domestica)
Mammalia NAA16 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAA16 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Naa16 35
  • 88.12 (n)
  • 88.77 (a)
chicken
(Gallus gallus)
Aves NAA16 35
  • 84.26 (n)
  • 89 (a)
NAA16 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAA16 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia naa16 35
  • 76.16 (n)
  • 82.29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002284 35
  • 54.98 (n)
  • 57.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nat1 36
  • 50 (a)
OneToMany
Nat1 35
  • 53.89 (n)
  • 54.66 (a)
worm
(Caenorhabditis elegans)
Secernentea hpo-29 36
  • 40 (a)
OneToMany
hpo-29 35
  • 51.53 (n)
  • 41.76 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAT1 36
  • 29 (a)
OneToMany
NAT1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB2753 35
  • 53.35 (n)
  • 45.17 (a)
rice
(Oryza sativa)
Liliopsida Os.11466 35
Os01g0617500 35
  • 52.52 (n)
  • 43.91 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11379 35
  • 45.46 (n)
  • 39.26 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes naa15 35
  • 49.62 (n)
  • 41.22 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5282 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10581 36
  • 49 (a)
OneToMany
Species with no ortholog for NAA16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NAA16 Gene

ENSEMBL:
Gene Tree for NAA16 (if available)
TreeFam:
Gene Tree for NAA16 (if available)

Paralogs for NAA16 Gene

Paralogs for NAA16 Gene

(3) SIMAP similar genes for NAA16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NAA16: view

Variants for NAA16 Gene

Sequence variations from dbSNP and Humsavar for NAA16 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_052618 -
rs1572017 -- 41,312,144(-) CAAAC(C/T)TTTTC intron-variant
rs2026467 -- 41,314,272(-) TAATA(A/C)TCATA intron-variant
rs2501946 -- 41,312,105(-) TCCTA(A/G)AGTTG intron-variant
rs2501947 -- 41,312,016(-) GCAAT(C/G)TAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA16 Gene

Variant ID Type Subtype PubMed ID
esv2498442 CNV Insertion 19546169
esv269506 CNV Insertion 20981092
esv2494010 CNV Deletion 19546169
esv2747303 CNV Deletion 23290073
esv2073591 CNV Deletion 18987734
esv4789 CNV Deletion 18987735
esv1009722 CNV Deletion 20482838
esv1370240 CNV Deletion 17803354

Variation tolerance for NAA16 Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAA16 Gene

HapMap Linkage Disequilibrium report
NAA16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA16 Gene

Disorders for NAA16 Gene

Relevant External Links for NAA16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAA16

No disorders were found for NAA16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA16 Gene

Publications for NAA16 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B. … Sherman F. (BMC Proc. 2009) 2 3 4 67
  2. A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1). (PMID: 19480662) Arnesen T. … Lillehaug J.R. (BMC Biochem. 2009) 2 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for NAA16 Gene

Sources for NAA16 Gene

Back to Top

Content