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Aliases for NAA15 Gene

Aliases for NAA15 Gene

  • N(Alpha)-Acetyltransferase 15, NatA Auxiliary Subunit 2 3
  • NARG1 3 4 6
  • NATH 3 4 6
  • NMDA Receptor-Regulated Protein 1 3 4
  • N-Terminal Acetyltransferase 3 4
  • Gastric Cancer Antigen Ga19 3 4
  • NMDA Receptor Regulated 1 2 3
  • Protein Tubedown-1 3 4
  • TBDN100 3 4
  • Ga19 3 4
  • N-Alpha-Acetyltransferase 15, NatA Auxiliary Subunit 3
  • Transcriptional Coactivator Tubedown-100 3
  • Tubedown-1 3
  • NAT1P 3
  • TBDN 3

External Ids for NAA15 Gene

Previous Symbols for NAA15 Gene

  • NARG1

Summaries for NAA15 Gene

Entrez Gene Summary for NAA15 Gene

  • This gene encodes a protein of unknown function. However, similarity to proteins in yeast and other species suggests that this protein may be an N-acetyltransferase. [provided by RefSeq, Jul 2008]

GeneCards Summary for NAA15 Gene

NAA15 (N(Alpha)-Acetyltransferase 15, NatA Auxiliary Subunit) is a Protein Coding gene. GO annotations related to this gene include ribosome binding and acetyltransferase activity. An important paralog of this gene is NAA16.

UniProtKB/Swiss-Prot for NAA15 Gene

  • Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.

Gene Wiki entry for NAA15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA15 Gene

Genomics for NAA15 Gene

Genomic Location for NAA15 Gene

Start:
139,301,455 bp from pter
End:
139,420,033 bp from pter
Size:
118,579 bases
Orientation:
Plus strand

Genomic View for NAA15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAA15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA15 Gene

No data available for Regulatory Elements for NAA15 Gene

Proteins for NAA15 Gene

  • Protein details for NAA15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXJ9-NAA15_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 15, NatA auxiliary subunit
    Protein Accession:
    Q9BXJ9
    Secondary Accessions:
    • D3DNY6
    • Q52LG9
    • Q8IWH4
    • Q8NEV2
    • Q9H8P6

    Protein attributes for NAA15 Gene

    Size:
    866 amino acids
    Molecular mass:
    101272 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 or probably NAA11 and NAA15. Interacts with XRCC6, NAA50 and XRCC5. Associates with HYPK when in a complex with NAA10.
    SequenceCaution:
    • Sequence=AAH39818.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for NAA15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA15 Gene

Proteomics data for NAA15 Gene at MOPED

Post-translational modifications for NAA15 Gene

  • Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys34, Lys41, Lys52, Lys262, Lys266, Lys286, Lys305, Lys312, Lys454, Lys496, Lys543, Lys659, Lys756, and Lys770

Other Protein References for NAA15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAA15 Gene

Domains for NAA15 Gene

Gene Families for NAA15 Gene

HGNC:
  • NAA :N(alpha)-acetyltransferase subunits

UniProtKB/Swiss-Prot:

NAA15_HUMAN
Similarity:
  • Contains 8 TPR repeats.:
    • Q9BXJ9
genes like me logo Genes that share domains with NAA15: view

Function for NAA15 Gene

Molecular function for NAA15 Gene

UniProtKB/Swiss-Prot Function: Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.

Gene Ontology (GO) - Molecular Function for NAA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12145306
GO:0008080 N-acetyltransferase activity IEA --
GO:0016407 contributes_to acetyltransferase activity IDA 15496142
GO:0043022 contributes_to ribosome binding IDA 15496142
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NAA15: view

Phenotypes for NAA15 Gene

GenomeRNAi human phenotypes for NAA15:
genes like me logo Genes that share phenotypes with NAA15: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NAA15 Gene

Localization for NAA15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA15 Gene

Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAA15 Gene COMPARTMENTS Subcellular localization image for NAA15 gene
Compartment Confidence
nucleus 5
cytosol 3
chloroplast 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NAA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12140756
GO:0005667 transcription factor complex IDA 12145306
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
GO:0031415 NatA complex IDA 15496142
genes like me logo Genes that share ontologies with NAA15: view

Pathways for NAA15 Gene

SuperPathways for NAA15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006474 N-terminal protein amino acid acetylation IDA 15496142
GO:0030154 cell differentiation IEA --
GO:0043066 negative regulation of apoptotic process IMP 19480662
genes like me logo Genes that share ontologies with NAA15: view

No data available for Pathways by source for NAA15 Gene

Compounds for NAA15 Gene

(1) Novoseek inferred chemical compound relationships for NAA15 Gene

Compound -log(P) Hits PubMed IDs
n-atc 89.6 1
genes like me logo Genes that share compounds with NAA15: view

Transcripts for NAA15 Gene

Unigene Clusters for NAA15 Gene

N(alpha)-acetyltransferase 15, NatA auxiliary subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAA15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
SP1: - -
SP2: - - -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:

ExUns: 20b ^ 21 ^ 22a · 22b ^ 23
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8:

Relevant External Links for NAA15 Gene

GeneLoc Exon Structure for
NAA15
ECgene alternative splicing isoforms for
NAA15

Expression for NAA15 Gene

mRNA expression in normal human tissues for NAA15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAA15 Gene

SOURCE GeneReport for Unigene cluster for NAA15 Gene Hs.745047

mRNA Expression by UniProt/SwissProt for NAA15 Gene

Q9BXJ9-NAA15_HUMAN
Tissue specificity: Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy.
genes like me logo Genes that share expressions with NAA15: view

Orthologs for NAA15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAA15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA15 36
  • 99.85 (n)
  • 99.88 (a)
NAA15 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAA15 36
  • 96.04 (n)
  • 99.19 (a)
NAA15 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAA15 36
  • 95.92 (n)
  • 99.14 (a)
NAA15 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Naa15 36
  • 93.14 (n)
  • 98.5 (a)
Naa15 16
Naa15 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAA15 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 95 (a)
OneToMany
-- 37
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Naa15 36
  • 92.52 (n)
  • 98.03 (a)
chicken
(Gallus gallus)
Aves NAA15 36
  • 85.67 (n)
  • 95.83 (a)
NAA15 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAA15 37
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4200 36
tropical clawed frog
(Silurana tropicalis)
Amphibia naa15 36
  • 80.52 (n)
  • 90.05 (a)
Str.7467 36
zebrafish
(Danio rerio)
Actinopterygii Dr.15380 36
naa15a 36
  • 69.75 (n)
  • 80.23 (a)
naa15a 37
  • 80 (a)
OneToMany
naa15b 37
  • 85 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Nat1 37
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hpo-29 37
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAT1 37
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10581 37
  • 50 (a)
OneToMany
Species with no ortholog for NAA15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA15 Gene

ENSEMBL:
Gene Tree for NAA15 (if available)
TreeFam:
Gene Tree for NAA15 (if available)

Paralogs for NAA15 Gene

Paralogs for NAA15 Gene

Selected SIMAP similar genes for NAA15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NAA15: view

Variants for NAA15 Gene

Sequence variations from dbSNP and Humsavar for NAA15 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2169 -- 139,312,195(-) TCTCA(C/G)TAAGA intron-variant
rs747004 -- 139,333,364(+) gtgca(C/T)tgcta intron-variant
rs765620 -- 139,375,468(-) AAAAA(A/G)AAAAG intron-variant
rs998310 -- 139,387,830(-) TACTG(G/T)GAATT intron-variant
rs1026184 -- 139,350,733(-) ATTAC(C/G)TCTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA15 Gene

Variant ID Type Subtype PubMed ID
nsv880160 CNV Gain 21882294
dgv977e199 CNV Deletion 23128226
esv2728426 CNV Deletion 23290073
nsv822748 CNV Loss 20364138
nsv442922 CNV CNV 18776908
nsv514254 CNV Loss 21397061
nsv4529 CNV Insertion 18451855
nsv830084 CNV Loss 17160897

Relevant External Links for NAA15 Gene

HapMap Linkage Disequilibrium report
NAA15
Human Gene Mutation Database (HGMD)
NAA15

Disorders for NAA15 Gene

(2) Novoseek inferred disease relationships for NAA15 Gene

Disease -log(P) Hits PubMed IDs
thyroid papillary carcinoma 57.6 5
tumors 0 3
genes like me logo Genes that share disorders with NAA15: view

No data available for UniProtKB/Swiss-Prot for NAA15 Gene

Publications for NAA15 Gene

  1. NATH, a novel gene overexpressed in papillary thyroid carcinomas. (PMID: 12140756) Fluge O. … Lillehaug J.R. (Oncogene 2002) 2 3 4 23
  2. Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex. (PMID: 12145306) Willis D.M. … Towler D.A. (J. Biol. Chem. 2002) 3 4 23
  3. A novel Xenopus acetyltransferase with a dynamic expression in early development. (PMID: 11478804) Choi S.C. … Han J.K. (Biochem. Biophys. Res. Commun. 2001) 2 3 23
  4. Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase. (PMID: 16638120) Arnesen T. … Lillehaug J.R. (BMC Biochem. 2006) 3 4 23
  5. Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. (PMID: 15496142) Arnesen T. … Lillehaug J.R. (Biochem. J. 2005) 3 4 23

Products for NAA15 Gene

Sources for NAA15 Gene

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