Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NAA15 Gene

protein-coding   GIFtS: 50
GCID: GC04P140222

N(Alpha)-Acetyltransferase 15, NatA Auxiliary Subunit

(Previous name: NMDA receptor regulated 1)
(Previous symbol: NARG1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
N(Alpha)-Acetyltransferase 15, NatA Auxiliary Subunit1 2     Ga192
NARG11 2 3 5     NAT1P2
NATH2 3 5     TBDN2
NMDA Receptor Regulated 11 2     N-Alpha-Acetyltransferase 15, NatA Auxiliary Subunit2
Gastric Cancer Antigen Ga192 3     Transcriptional Coactivator Tubedown-1002
Protein Tubedown-12 3     tubedown-12
TBDN1002 3     GA193
N-Terminal Acetyltransferase2 3     Tbdn1003
NMDA Receptor-Regulated Protein 12 3     

External Ids:    HGNC: 307821   Entrez Gene: 801552   Ensembl: ENSG000001641347   OMIM: 6080005   UniProtKB: Q9BXJ93   

Export aliases for NAA15 gene to outside databases

Previous GC identifer: GC04P135952


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NAA15 Gene:
This gene encodes a protein of unknown function. However, similarity to proteins in yeast and other species
suggests that this protein may be an N-acetyltransferase. (provided by RefSeq, Jul 2008)

GeneCards Summary for NAA15 Gene:
NAA15 (N(alpha)-acetyltransferase 15, NatA auxiliary subunit) is a protein-coding gene. Diseases associated with NAA15 include retinopathy of prematurity, and estrogen-receptor negative breast cancer. GO annotations related to this gene include acetyltransferase activity and ribosome binding. An important paralog of this gene is NAA16.

UniProtKB/Swiss-Prot: NAA15_HUMAN, Q9BXJ9
Function: Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal)
acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and
development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with
XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter

Gene Wiki entry for NAA15 (NARG1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Search for regulatory transcription factor binding sites for NAA15
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAA15 promoter sequence
   Search Chromatin IP Primers for NAA15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAA15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.1   Ensembl cytogenetic band:  4q31.1   HGNC cytogenetic band: 4q31.1

NAA15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAA15 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P140222:  view genomic region     (about GC identifiers)

Start:
140,222,609 bp from pter      End:
140,341,187 bp from pter
Size:
118,579 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NAA15_HUMAN, Q9BXJ9 (See protein sequence)
Recommended Name: N-alpha-acetyltransferase 15, NatA auxiliary subunit  
Size: 866 amino acids; 101272 Da
Subunit: Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 or probably NAA11 and
NAA15. Interacts with XRCC6, NAA50 and XRCC5. Associates with HYPK when in a complex with NAA10
Sequence caution: Sequence=AAH39818.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: D3DNY6 Q52LG9 Q8IWH4 Q8NEV2 Q9H8P6
Alternative splicing: 2 isoforms:  Q9BXJ9-1   Q9BXJ9-4   

Explore the universe of human proteins at neXtProt for NAA15: NX_Q9BXJ9

Explore proteomics data for NAA15 at MOPED

Post-translational modifications: 

  • Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment1
  • Ubiquitination2 at Lys34, Lys41, Lys52, Lys262, Lys266, Lys286, Lys305, Lys312, Lys454, Lys496,
                                 Lys543, Lys659, Lys756, Lys770
  • Modification sites at PhosphoSitePlus

  • See NAA15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_476516.1  
    ENSEMBL proteins: 
     ENSP00000296543   ENSP00000381920   ENSP00000421839  

    NAA15 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NAA15
    GenScript Custom Purified and Recombinant Proteins Services for NAA15
    Novus Biologicals NAA15 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    NAA15 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for NAA15
    OriGene Custom Antibody Services for NAA15
    Novus Biologicals NAA15 Antibodies
    Abcam antibodies for NAA15
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for NAA15
    LSBio Antibodies in human, mouse, rat for NAA15

    NAA15 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NAA15
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NAA15
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    NAA: N(alpha)-acetyltransferase subunits

    5 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom
     IPR021183 NatA_aux_su
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q9BXJ9

    ProtoNet protein and cluster: Q9BXJ9

    1 Blocks protein domain: IPB002197 FIS bacterial regulatory protein HTH signature

    UniProtKB/Swiss-Prot: NAA15_HUMAN, Q9BXJ9
    Similarity: Contains 8 TPR repeats


    NAA15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAA15_HUMAN, Q9BXJ9
    Function: Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal)
    acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and
    development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with
    XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12145306
    GO:0008080N-acetyltransferase activity IEA--
    GO:0016407contributes to acetyltransferase activity IDA15496142
    GO:0043022contributes to ribosome binding IDA15496142
    GO:0044822poly(A) RNA binding IDA--
         
    NAA15 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NAA15:
     Increased G1 DNA content  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NAA15
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NAA15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NAA15
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NAA15

    miRNA
    Products:
        
    miRTarBase miRNAs that target NAA15:
    hsa-mir-124-3p (MIRT004101), hsa-mir-103a-3p (MIRT027203), hsa-mir-590-3p (MIRT016209), hsa-let-7b-5p (MIRT032425), hsa-mir-98-5p (MIRT027747), hsa-mir-16-5p (MIRT005271)

    Block miRNA regulation of human, mouse, rat NAA15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAA15 (see all 138):
    hsa-miR-128 hsa-miR-3653 hsa-miR-92b hsa-miR-509-3-5p hsa-miR-761 hsa-miR-374b* hsa-miR-130a* hsa-miR-32
    SwitchGear 3'UTR luciferase reporter plasmidNAA15 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NAA15
    Predesigned siRNA for gene silencing in human, mouse, rat NAA15

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NAA15

    Clone
    Products:
         
    OriGene clones in human, mouse for NAA15 (see all 7)
    OriGene ORF clones in mouse, rat for NAA15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NAA15 (NM_057175)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAA15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAA15

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NAA15
    Browse ESI BIO Cell Lines and PureStem Progenitors for NAA15 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NAA15_HUMAN, Q9BXJ9: Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free
    cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    chloroplast1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12140756
    GO:0005667transcription factor complex IDA12145306
    GO:0005737cytoplasm IDA--
    GO:0031415NatA complex IDA15496142

    NAA15 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NAA15
    Interactions:

        Search GeneGlobe Interaction Network for NAA15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NAA15 (Q9BXJ93 ENSP000002965434) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NAA10P412273, ENSP000004177634I2D: score=4 STRING: ENSP00000417763
    UBA5Q9GZZ93, ENSP000003485654I2D: score=2 STRING: ENSP00000348565
    XRCC6P129563, ENSP000003522574I2D: score=2 STRING: ENSP00000352257
    RPL26P612543, ENSP000002938424I2D: score=1 STRING: ENSP00000293842
    TNIKQ9UKE53, ENSP000003995114I2D: score=1 STRING: ENSP00000399511
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006474N-terminal protein amino acid acetylation IDA15496142
    GO:0030154cell differentiation IEA--
    GO:0043066negative regulation of apoptotic process IMP19480662

    NAA15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAA15

    1 Novoseek inferred chemical compound relationship for NAA15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-atc 89.6 1 15911569 (1)



    NAA15 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NAA15 gene: 
    NM_057175.3  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296543(uc003ihu.1) ENST00000398947 ENST00000482087 ENST00000480277
    ENST00000468029 ENST00000496716 ENST00000485905 ENST00000515576
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NAA15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAA15 (see all 138):
    hsa-miR-128 hsa-miR-3653 hsa-miR-92b hsa-miR-509-3-5p hsa-miR-761 hsa-miR-374b* hsa-miR-130a* hsa-miR-32
    SwitchGear 3'UTR luciferase reporter plasmidNAA15 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NAA15
    Predesigned siRNA for gene silencing in human, mouse, rat NAA15
    Clone
    Products:
         
    OriGene clones in human, mouse for NAA15 (see all 7)
    OriGene ORF clones in mouse, rat for NAA15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NAA15 (NM_057175)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAA15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAA15
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NAA15
    OriGene qSTAR qPCR primer pairs in human, mouse for NAA15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAA15
      QuantiTect SYBR Green Assays in human, mouse, rat NAA15
      QuantiFast Probe-based Assays in human, mouse, rat NAA15

    Selected AceView cDNA sequences (see all 148):

    BX111747 AA761423 AI804279 CA418241 NM_025085 BM044197 AJ314788 CA429026 
    BM463359 AA907375 AW294949 AY112670 CK570340 AU134337 BX116461 AA039428 
    BP871471 BM834812 AA039352 BQ214565 AU130763 BC039818 BM456794 BX647018 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NAA15 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
    SP1:                    -     -                                                                                                                                 
    SP2:                    -     -                                                                                   -                                             
    SP3:                    -                                                                                                                                       
    SP4:                          -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 20b ^ 21 ^ 22a · 22b ^ 23
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:  -                           


    ECgene alternative splicing isoforms for NAA15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NAA15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGACAAAG
    NAA15 Expression
    About this image


    NAA15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
    NAA15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAA15 Protein Expression

    UniProtKB/Swiss-Prot: NAA15_HUMAN, Q9BXJ9
    Tissue specificity: Expressed at high levels in testis and in ocular endothelial cells. Also found in brain
    (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver,
    pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract.
    Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi).
    Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic
    retinopathy

        Custom PCR Arrays for NAA15
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NAA15
    OriGene qSTAR qPCR primer pairs in human, mouse for NAA15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAA15
    QuantiTect SYBR Green Assays in human, mouse, rat NAA15
    QuantiFast Probe-based Assays in human, mouse, rat NAA15
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NAA15 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Naa151 , 5 N(alpha)-acetyltransferase 15, NatA auxiliary subunit1, 5 93.14(n)1
    98.5(a)1
      3 (22.47 cM)5
    748381  NM_053089.31  NP_444319.31 
     514160165 
    chicken
    (Gallus gallus)
    Aves NAA151 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 85.67(n)
    95.83(a)
      422440  XM_420407.4  XP_420407.4 
    lizard
    (Anolis carolinensis)
    Reptilia NAA156
    N(alpha)-acetyltransferase 15, NatA auxiliary subu...
    96(a)
    1 ↔ 1
    5(120269656-120307473)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.42002 Xenopus laevis putative N-terminal acetyltransferase more 80.29(n)    AF247679.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.153802 Danio rerio, Similar to transcriptional coactivator more 75.45(n)    AY391464.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nat16
    Nat1
    51(a)
    1 → many
    X(19374186-19378676)
    worm
    (Caenorhabditis elegans)
    Secernentea hpo-296
    Protein HPO-29 (hpo-29) mRNA, complete cds
    42(a)
    1 → many
    III(235844-253376) WBGene00021754
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NAT16
    Subunit of the N-terminal acetyltransferase NatA (...
    28(a)
    1 → many
    IV(378874-381438) YDL040C


    ENSEMBL Gene Tree for NAA15 (if available)
    TreeFam Gene Tree for NAA15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NAA15 gene
    NAA162  
    10 SIMAP similar genes for NAA15 using alignment to 2 protein entries:     NAA15_HUMAN (see all proteins):
    NARG1    NAA16    NARG1L    PAM16    L3MBTL2    ABCG5
    RHBDD3    ADCY7    SYNE1    LOC100506127

    NAA15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NAA15 (see all 1578)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1817145331,2
    --140225827(+) TTTTAC/TCTATG 1 -- int10--------
    rs802119471,2
    F--140225884(+) GCAGCA/GTTATC 1 -- int10--------
    rs1499726051,2
    --140225910(+) ACCACC/TACAAT 1 -- int10--------
    rs1856882091,2
    --140225925(+) CTACAC/GAACAA 1 -- int10--------
    rs1442286781,2
    --140225951(+) AGTACC/TCCCCT 1 -- int10--------
    rs1893641621,2
    --140226010(+) ATCCCC/TTCTCG 1 -- int10--------
    rs786472451,2
    C,F--140226205(+) AGTAGG/CGGGGA 1 -- int13Minor allele frequency- C:0.26CSA WA 121
    rs1158786651,2
    C,F--140226221(+) ACAGGG/TCTACT 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1400473271,2
    C--140226377(+) CTGTAA/CGTTTA 1 -- int10--------
    rs1436706621,2
    --140226592(+) CTTTTA/GAGATT 1 -- int10--------

    HapMap Linkage Disequilibrium report for NAA15 (140222609 - 140341187 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NAA15:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728426CNV Deletion23290073
    dgv977e199CNV Deletion23128226
    nsv4529CNV Insertion18451855
    nsv830084CNV Loss17160897
    nsv822748CNV Loss20364138
    nsv514254CNV Loss21397061
    nsv880160CNV Gain21882294
    nsv442922CNV CNV18776908

    Human Gene Mutation Database (HGMD): NAA15
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NAA15
    DNA2.0 Custom Variant and Variant Library Synthesis for NAA15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608000    OMIM disorders: --

    17 diseases for NAA15:    
    About MalaCards
    retinopathy of prematurity    estrogen-receptor negative breast cancer    papillary carcinoma    proliferative diabetic retinopathy
    diabetic retinopathy    papillary thyroid carcinoma    papilloma    burkitt's lymphoma
    herpes simplex    thyroiditis    retinitis    tuberculosis
    breast cancer    colorectal cancer    endotheliitis    malaria
    neuronitis


    NAA15 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for NAA15 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid papillary carcinoma 57.6 5 12140756 (2), 16279846 (2), 18991565 (1)
    tumors 0 3 12140756 (2), 16279846 (1)


    Export disorders for NAA15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NAA15 gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with NAA15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NATH, a novel gene overexpressed in papillary thyroid carcinomas. (PubMed id 12140756)1, 2, 3, 9 Fluge O.... Lillehaug J.R. (Oncogene 2002)
    2. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PubMed id 19660095)1, 2, 3 Polevoda B.... Sherman F. (BMC Proc. 2009)
    3. Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. (PubMed id 15496142)1, 2, 9 Arnesen T....Lillehaug J.R. (Biochem. J. 2005)
    4. Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex. (PubMed id 12145306)1, 2, 9 Willis D.M.... Towler D.A. (J. Biol. Chem. 2002)
    5. Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase. (PubMed id 16638120)1, 2, 9 Arnesen T.... Lillehaug J.R. (BMC Biochem. 2006)
    6. A novel Xenopus acetyltransferase with a dynamic expression in early development. (PubMed id 11478804)1, 3, 9 Choi S.C....Han J.K. (Biochem. Biophys. Res. Commun. 2001)
    7. The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation. (PubMed id 20154145)1, 2 Arnesen T.... Anderson D. (Mol. Cell. Biol. 2010)
    8. Cloning and characterization of hNAT5/hSAN: an evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex. (PubMed id 16507339)1, 2 Arnesen T....Lillehaug J.R. (Gene 2006)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 80155 HGNC: 30782 AceView: TBDN100 Ensembl:ENSG00000164134 euGenes: HUgn80155
    ECgene: NAA15 H-InvDB: NAA15

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NAA15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NAA15 gene:
    Search GeneIP for patents involving NAA15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NAA15   OriGene RNAi products in human, mouse, rat for NAA15  
     OriGene qPCR primer pairs and template standards for NAA15   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NAA15  
     OriGene qSTAR qPCR primer pairs in human, mouse for NAA15   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NAA15   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NAA15   OriGene Custom Protein Services for NAA15  

     
     
     Block miRNA regulation of human, mouse, rat NAA15 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NAA15
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAA15 Predesigned siRNA for gene silencing in human, mouse, rat NAA15
     QuantiFast Probe-based Assays in human, mouse, rat NAA15 QuantiTect SYBR Green Assays in human, mouse, rat NAA15
     Custom PCR Arrays for NAA15 Search Chromatin IP Primers for NAA15
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAA15  Search GeneGlobe Interaction Network for NAA15
     Search Regulatory tfbs for NAA15
     GenScript Custom Purified and Recombinant Proteins Services for NAA15 GenScript cDNA clones with any tag delivered in your preferred vector for NAA15
     GenScript Custom Assay Services for NAA15 GenScript Custom overexpressing Cell Line Services for NAA15
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NAA15
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NAA15 antibodies
     NAA15 proteins
     Antibodies for NAA15
     See all of Abcam's Antibodies, Kits and Proteins for NAA15
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for NAA15
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA15
     SwitchGear 3'UTR luciferase reporter plasmids for NAA15
     SwitchGear Promoter luciferase reporter plasmids for NAA15
     ThermoFisher Antibodies for NAA15
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAA15
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NAA15
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NAA15
     LSBio Antibodies in human, mouse, rat for NAA15
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NAA15 gene at Home site.
    Version: 3.12.164 25 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4