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Aliases for NAA11 Gene

Aliases for NAA11 Gene

  • N(Alpha)-Acetyltransferase 11, NatA Catalytic Subunit 2 3 5
  • N-Terminal Acetyltransferase Complex ARD1 Subunit Homolog B 3 4
  • NatA Catalytic Subunit Naa11 3 4
  • ARD1B 3 4
  • HARD2 3 4
  • ARD2 3 4
  • =N-Terminal Acetyltransferase Complex ARD1 Subunit Homolog B 3
  • ARD1 Homolog B (S. Cerevisiae) 2
  • N-Alpha-Acetyltransferase 11 3
  • Human Arrest Defective 2 3
  • ARD1 Homolog B 3
  • EC 2.3.1.255 4

External Ids for NAA11 Gene

Previous HGNC Symbols for NAA11 Gene

  • ARD1B

Previous GeneCards Identifiers for NAA11 Gene

  • GC04M080237
  • GC04M075985

Summaries for NAA11 Gene

GeneCards Summary for NAA11 Gene

NAA11 (N(Alpha)-Acetyltransferase 11, NatA Catalytic Subunit) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and peptide alpha-N-acetyltransferase activity. An important paralog of this gene is NAA10.

UniProtKB/Swiss-Prot for NAA11 Gene

  • Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA11 Gene

Genomics for NAA11 Gene

Regulatory Elements for NAA11 Gene

Enhancers for NAA11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G079209 1.9 FANTOM5 Ensembl ENCODE dbSUPER 8.5 +114.9 114920 4.2 HDGF FOXA2 PKNOX1 MLX CREB3L1 ARNT YY1 ZNF766 SP5 JUNB NAA11 GC04P079267 GC04M079034
GH04G079360 0.7 dbSUPER 17.5 -38.5 -38457 8.0 EP300 ATF2 ZNF766 ZNF316 SMARCA4 POLR2A IKZF1 ZNF600 EMSY MAFK NAA11 LOC105377300
GH04G079382 2 dbSUPER 4.5 -61.5 -61451 9.6 PKNOX1 ARNT FEZF1 ZNF2 KLF7 FOS ZNF488 TSHZ1 REST ZNF623 PCAT4 ANXA3 NAA11 LOC105377300 GK2
GH04G079383 2 dbSUPER 4.5 -61.5 -61451 9.6 PKNOX1 ARNT FEZF1 ZNF2 KLF7 FOS ZNF488 TSHZ1 REST ZNF623 PCAT4 ANXA3 NAA11 LOC105377300 GK2
GH04G079048 1.5 dbSUPER 5.8 +275.4 275428 4.4 CTCF POLR2A SMARCA4 NFE2 LINC01088 NAA11 GC04M079034 GC04P079267
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAA11 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAA11 Gene

Chromosome:
4
Start:
79,225,694 bp from pter
End:
79,326,050 bp from pter
Size:
100,357 bases
Orientation:
Minus strand

Genomic View for NAA11 Gene

Genes around NAA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA11 Gene

Proteins for NAA11 Gene

  • Protein details for NAA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSU3-NAA11_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 11
    Protein Accession:
    Q9BSU3
    Secondary Accessions:
    • Q66K19
    • Q6P479

    Protein attributes for NAA11 Gene

    Size:
    229 amino acids
    Molecular mass:
    25979 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA11 and NAA15 (Probable). Interacts with HIF1A.
    SequenceCaution:
    • Sequence=AAH04552.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH63623.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH80651.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NAA11 Gene

Post-translational modifications for NAA11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAA11 Gene

No data available for DME Specific Peptides for NAA11 Gene

Domains & Families for NAA11 Gene

Protein Domains for NAA11 Gene

Suggested Antigen Peptide Sequences for NAA11 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BSU3

UniProtKB/Swiss-Prot:

NAA11_HUMAN :
  • Belongs to the acetyltransferase family. ARD1 subfamily.
Family:
  • Belongs to the acetyltransferase family. ARD1 subfamily.
genes like me logo Genes that share domains with NAA11: view

Function for NAA11 Gene

Molecular function for NAA11 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + an N-terminal-glycyl-[protein] = an N-terminal-N(alpha)-acetyl-glycyl-[protein] + CoA.
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + an N-terminal-L-alanyl-[protein] = an N-terminal-N(alpha)-acetyl-L-alanyl-[protein] + CoA.
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + an N-terminal-L-seryl-[protein] = an N-terminal-N(alpha)-acetyl-L-seryl-[protein] + CoA.
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + an N-terminal-L-valyl-[protein] = an N-terminal-N(alpha)-acetyl-L-valyl-[protein] + CoA.
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + an N-terminal-L-cysteinyl-[protein] = an N-terminal-N(alpha)-acetyl-L-cysteinyl-[protein] + CoA.
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + an N-terminal-L-threonyl-[protein] = an N-terminal-N(alpha)-acetyl-L-threonyl-[protein] + CoA.
UniProtKB/Swiss-Prot Function:
Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.

Enzyme Numbers (IUBMB) for NAA11 Gene

Gene Ontology (GO) - Molecular Function for NAA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 peptide alpha-N-acetyltransferase activity IDA 16638120
GO:0005515 protein binding IPI 19480662
GO:0008080 N-acetyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with NAA11: view
genes like me logo Genes that share phenotypes with NAA11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NAA11

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NAA11 Gene

Localization for NAA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAA11 gene
Compartment Confidence
nucleus 4
cytosol 4
extracellular 1

Gene Ontology (GO) - Cellular Components for NAA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0022626 cytosolic ribosome IBA --
GO:0031415 NatA complex IDA 16638120
genes like me logo Genes that share ontologies with NAA11: view

Pathways & Interactions for NAA11 Gene

SuperPathways for NAA11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006474 N-terminal protein amino acid acetylation IDA 16638120
GO:0006475 internal protein amino acid acetylation IBA --
GO:0017198 N-terminal peptidyl-serine acetylation IBA --
GO:0018002 N-terminal peptidyl-glutamic acid acetylation IBA --
genes like me logo Genes that share ontologies with NAA11: view

No data available for Pathways by source and SIGNOR curated interactions for NAA11 Gene

Drugs & Compounds for NAA11 Gene

(1) Drugs for NAA11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for NAA11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
genes like me logo Genes that share compounds with NAA11: view

Transcripts for NAA11 Gene

mRNA/cDNA for NAA11 Gene

Unigene Clusters for NAA11 Gene

N(alpha)-acetyltransferase 11, NatA catalytic subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA11 Gene

No ASD Table

Relevant External Links for NAA11 Gene

GeneLoc Exon Structure for
NAA11
ECgene alternative splicing isoforms for
NAA11

Expression for NAA11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAA11 Gene

mRNA differential expression in normal tissues according to GTEx for NAA11 Gene

This gene is overexpressed in Testis (x34.4).

Protein differential expression in normal tissues from HIPED for NAA11 Gene

This gene is overexpressed in Testis (42.4), Heart (17.9), and Ovary (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAA11 Gene



Protein tissue co-expression partners for NAA11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAA11 Gene:

NAA11

SOURCE GeneReport for Unigene cluster for NAA11 Gene:

Hs.676048

mRNA Expression by UniProt/SwissProt for NAA11 Gene:

Q9BSU3-NAA11_HUMAN
Tissue specificity: Present in several cell lines, with highest levels in MCF-7 cells (at protein level).

Evidence on tissue expression from TISSUES for NAA11 Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with NAA11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAA11 Gene

Orthologs for NAA11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA11 34 35
  • 99.42 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 89 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NAA11 34 35
  • 87.92 (n)
mouse
(Mus musculus)
Mammalia Gm16286 35
  • 86 (a)
OneToMany
Naa11 34 16 35
  • 83.89 (n)
dog
(Canis familiaris)
Mammalia NAA11 34 35
  • 85.01 (n)
rat
(Rattus norvegicus)
Mammalia Naa11 34
  • 83.81 (n)
zebrafish
(Danio rerio)
Actinopterygii naa10 35
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta vnc 35
  • 65 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K07H8.3 35
  • 66 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARD1 34 35
  • 57.4 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR409W 34
  • 57.32 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03367g 34
  • 55.85 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G13780 34
  • 65.54 (n)
rice
(Oryza sativa)
Liliopsida Os04g0635800 34
  • 62.69 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11133 35
  • 63 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes naa10 34
  • 62.12 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08944 34
  • 61.39 (n)
Species where no ortholog for NAA11 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAA11 Gene

ENSEMBL:
Gene Tree for NAA11 (if available)
TreeFam:
Gene Tree for NAA11 (if available)

Paralogs for NAA11 Gene

Paralogs for NAA11 Gene

(2) SIMAP similar genes for NAA11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NAA11: view

Variants for NAA11 Gene

Sequence variations from dbSNP and Humsavar for NAA11 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000039454 -- 79,161,882(+) TTCAC(C/T)ATATT intron-variant
rs1000047267 -- 79,279,487(+) AGGAG(C/T)TTATA intron-variant
rs1000057777 -- 79,267,581(+) TTACA(A/G)TGGAA intron-variant
rs1000108203 -- 79,267,125(+) CCTAT(G/T)TCATA intron-variant
rs1000118580 -- 79,281,756(+) AGGCT(C/G)TCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA11 Gene

Variant ID Type Subtype PubMed ID
esv2727859 CNV deletion 23290073
nsv1006026 CNV loss 25217958
nsv999174 CNV loss 25217958

Variation tolerance for NAA11 Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAA11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAA11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA11 Gene

Disorders for NAA11 Gene

Relevant External Links for NAA11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAA11

No disorders were found for NAA11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA11 Gene

Publications for NAA11 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B. … Sherman F. (BMC Proc. 2009) 2 3 4 64
  2. Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase. (PMID: 16638120) Arnesen T. … Lillehaug J.R. (BMC Biochem. 2006) 2 3 4 64
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  4. Expression of human NAA11 (ARD1B) gene is tissue-specific and is regulated by DNA methylation. (PMID: 22048246) Pang A.L. … Rennert O.M. (Epigenetics 2011) 3 64
  5. Up-regulation of human arrest-defective 1 protein is correlated with metastatic phenotype and poor prognosis in breast cancer. (PMID: 22292636) Wang Z.H. … Tan D.Y. (Asian Pac. J. Cancer Prev. 2011) 3 64

Products for NAA11 Gene

Sources for NAA11 Gene

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