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Aliases for NAA11 Gene

Aliases for NAA11 Gene

  • N(Alpha)-Acetyltransferase 11, NatA Catalytic Subunit 2 3 5
  • N-Terminal Acetyltransferase Complex ARD1 Subunit Homolog B 3 4
  • NatA Catalytic Subunit Naa11 3 4
  • ARD1B 3 4
  • HARD2 3 4
  • ARD2 3 4
  • =N-Terminal Acetyltransferase Complex ARD1 Subunit Homolog B 3
  • N-Alpha-Acetyltransferase 11, NatA Catalytic Subunit 3
  • ARD1 Homolog B (S. Cerevisiae) 2
  • Human Arrest Defective 2 3
  • ARD1 Homolog B 3
  • EC 4

External Ids for NAA11 Gene

Previous HGNC Symbols for NAA11 Gene

  • ARD1B

Previous GeneCards Identifiers for NAA11 Gene

  • GC04M080237
  • GC04M075985

Summaries for NAA11 Gene

GeneCards Summary for NAA11 Gene

NAA11 (N(Alpha)-Acetyltransferase 11, NatA Catalytic Subunit) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and peptide alpha-N-acetyltransferase activity. An important paralog of this gene is NAA10.

UniProtKB/Swiss-Prot for NAA11 Gene

  • Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA11 Gene

Genomics for NAA11 Gene

Regulatory Elements for NAA11 Gene

Enhancers for NAA11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NAA11 on UCSC Golden Path with GeneCards custom track

Promoters for NAA11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NAA11 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAA11 Gene

79,225,694 bp from pter
79,326,050 bp from pter
100,357 bases
Minus strand

Genomic View for NAA11 Gene

Genes around NAA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA11 Gene

Proteins for NAA11 Gene

  • Protein details for NAA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N-alpha-acetyltransferase 11
    Protein Accession:
    Secondary Accessions:
    • Q66K19
    • Q6P479

    Protein attributes for NAA11 Gene

    229 amino acids
    Molecular mass:
    25979 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA11 and NAA15 (Probable). Interacts with HIF1A.
    • Sequence=AAH04552.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH63623.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH80651.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NAA11 Gene

Proteomics data for NAA11 Gene at MOPED

Post-translational modifications for NAA11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAA11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAA11 Gene

Domains & Families for NAA11 Gene

Protein Domains for NAA11 Gene

Suggested Antigen Peptide Sequences for NAA11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 N-acetyltransferase domain.
  • Belongs to the acetyltransferase family. ARD1 subfamily.
  • Contains 1 N-acetyltransferase domain.
  • Belongs to the acetyltransferase family. ARD1 subfamily.
genes like me logo Genes that share domains with NAA11: view

Function for NAA11 Gene

Molecular function for NAA11 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
UniProtKB/Swiss-Prot Function:
Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.

Enzyme Numbers (IUBMB) for NAA11 Gene

Gene Ontology (GO) - Molecular Function for NAA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 peptide alpha-N-acetyltransferase activity IDA 16638120
GO:1990189 peptide-serine-N-acetyltransferase activity IBA --
GO:1990190 peptide-glutamate-N-acetyltransferase activity IBA --
genes like me logo Genes that share ontologies with NAA11: view
genes like me logo Genes that share phenotypes with NAA11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NAA11

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NAA11 Gene

Localization for NAA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for NAA11 Gene COMPARTMENTS Subcellular localization image for NAA11 gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for NAA11 Gene

Pathways & Interactions for NAA11 Gene

SuperPathways for NAA11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018002 N-terminal peptidyl-glutamic acid acetylation IBA --
genes like me logo Genes that share ontologies with NAA11: view

No data available for Pathways by source and SIGNOR curated interactions for NAA11 Gene

Drugs & Compounds for NAA11 Gene

(1) Drugs for NAA11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for NAA11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
genes like me logo Genes that share compounds with NAA11: view

Transcripts for NAA11 Gene

mRNA/cDNA for NAA11 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NAA11 Gene

N(alpha)-acetyltransferase 11, NatA catalytic subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAA11 Gene

No ASD Table

Relevant External Links for NAA11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAA11 Gene

mRNA expression in normal human tissues for NAA11 Gene

mRNA differential expression in normal tissues according to GTEx for NAA11 Gene

This gene is overexpressed in Testis (x34.4).

Protein differential expression in normal tissues from HIPED for NAA11 Gene

This gene is overexpressed in Testis (42.4), Heart (17.9), and Ovary (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAA11 Gene

SOURCE GeneReport for Unigene cluster for NAA11 Gene Hs.676048

mRNA Expression by UniProt/SwissProt for NAA11 Gene

Tissue specificity: Present in several cell lines, with highest levels in MCF-7 cells (at protein level).
genes like me logo Genes that share expression patterns with NAA11: view

Protein tissue co-expression partners for NAA11 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NAA11 Gene

Orthologs for NAA11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NAA11 35
  • 87.92 (n)
  • 90.39 (a)
NAA11 36
  • 90 (a)
(Canis familiaris)
Mammalia NAA11 35
  • 85.01 (n)
  • 86.03 (a)
NAA11 36
  • 86 (a)
(Mus musculus)
Mammalia Naa11 35
  • 83.89 (n)
  • 86.73 (a)
Naa11 16
Gm16286 36
  • 86 (a)
Naa11 36
  • 85 (a)
(Pan troglodytes)
Mammalia NAA11 35
  • 99.42 (n)
  • 98.69 (a)
NAA11 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Naa11 35
  • 83.81 (n)
  • 87.5 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
(Danio rerio)
Actinopterygii naa10 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta vnc 36
  • 65 (a)
(Caenorhabditis elegans)
Secernentea K07H8.3 36
  • 66 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR409W 35
  • 57.32 (n)
  • 56.69 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03367g 35
  • 55.85 (n)
  • 62.91 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARD1 35
  • 57.4 (n)
  • 59.6 (a)
ARD1 36
  • 41 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G13780 35
  • 65.54 (n)
  • 68.24 (a)
(Oryza sativa)
Liliopsida Os04g0635800 35
  • 62.69 (n)
  • 68.87 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08944 35
  • 61.39 (n)
  • 63.92 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes naa10 35
  • 62.12 (n)
  • 65.58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11133 36
  • 63 (a)
Species with no ortholog for NAA11:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAA11 Gene

Gene Tree for NAA11 (if available)
Gene Tree for NAA11 (if available)

Paralogs for NAA11 Gene

Paralogs for NAA11 Gene

(2) SIMAP similar genes for NAA11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NAA11: view

Variants for NAA11 Gene

Sequence variations from dbSNP and Humsavar for NAA11 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs3811765 - 79,325,862(-) GCAAC(A/G)CTCAG reference, missense
rs17003712 - 79,325,823(+) AAGGA(A/G)GTTGC reference, missense
rs1385056 -- 79,317,539(+) GCAGC(A/G)TAGTG utr-variant-3-prime
rs1484147 -- 79,317,859(+) AAGAA(C/T)ACTGG intron-variant
rs4473673 -- 79,319,589(-) TACTT(A/C/G/T)TGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA11 Gene

Variant ID Type Subtype PubMed ID
esv2727859 CNV Deletion 23290073
nsv879505 CNV Loss 21882294

Variation tolerance for NAA11 Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NAA11 Gene

Disorders for NAA11 Gene

Relevant External Links for NAA11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NAA11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAA11 Gene

Publications for NAA11 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B. … Sherman F. (BMC Proc. 2009) 2 3 4 67
  2. Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase. (PMID: 16638120) Arnesen T. … Lillehaug J.R. (BMC Biochem. 2006) 2 3
  3. Expression of human NAA11 (ARD1B) gene is tissue-specific and is regulated by DNA methylation. (PMID: 22048246) Pang A.L. … Rennert O.M. (Epigenetics 2011) 3
  4. Up-regulation of human arrest-defective 1 protein is correlated with metastatic phenotype and poor prognosis in breast cancer. (PMID: 22292636) Wang Z.H. … Tan D.Y. (Asian Pac. J. Cancer Prev. 2011) 3
  5. LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma. (PMID: 20419844) Huang G.L. … Wang H.Y. (World J. Gastroenterol. 2010) 3

Products for NAA11 Gene

Sources for NAA11 Gene