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Aliases for NAA11 Gene

Aliases for NAA11 Gene

  • N(Alpha)-Acetyltransferase 11, NatA Catalytic Subunit 2 3
  • N-Terminal Acetyltransferase Complex ARD1 Subunit Homolog B 3 4
  • NatA Catalytic Subunit Naa11 3 4
  • ARD1B 3 4
  • HARD2 3 4
  • ARD2 3 4
  • =N-Terminal Acetyltransferase Complex ARD1 Subunit Homolog B 3
  • N-Alpha-Acetyltransferase 11, NatA Catalytic Subunit 3
  • ARD1 Homolog B (S. Cerevisiae) 2
  • N-Alpha-Acetyltransferase 11 3
  • Human Arrest Defective 2 3
  • ARD1 Homolog B 3
  • EC 2.3.1.88 4

External Ids for NAA11 Gene

Previous HGNC Symbols for NAA11 Gene

  • ARD1B

Previous GeneCards Identifiers for NAA11 Gene

  • GC04M080237
  • GC04M075985

Summaries for NAA11 Gene

GeneCards Summary for NAA11 Gene

NAA11 (N(Alpha)-Acetyltransferase 11, NatA Catalytic Subunit) is a Protein Coding gene. GO annotations related to this gene include peptide alpha-N-acetyltransferase activity. An important paralog of this gene is NAA10.

UniProtKB/Swiss-Prot for NAA11 Gene

  • Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA11 Gene

Genomics for NAA11 Gene

Genomic Location for NAA11 Gene

Start:
79,225,694 bp from pter
End:
79,326,050 bp from pter
Size:
100,357 bases
Orientation:
Minus strand

Genomic View for NAA11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA11 Gene

No data available for Regulatory Elements for NAA11 Gene

Proteins for NAA11 Gene

  • Protein details for NAA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSU3-NAA11_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 11
    Protein Accession:
    Q9BSU3
    Secondary Accessions:
    • Q66K19
    • Q6P479

    Protein attributes for NAA11 Gene

    Size:
    229 amino acids
    Molecular mass:
    25979 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA11 and NAA15 (Probable). Interacts with HIF1A.
    SequenceCaution:
    • Sequence=AAH04552.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH63623.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH80651.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NAA11 Gene

Proteomics data for NAA11 Gene at MOPED

Post-translational modifications for NAA11 Gene

  • Ubiquitination at Lys89, Lys105, and Lys148
  • Modification sites at PhosphoSitePlus

Other Protein References for NAA11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAA11 Gene

Domains for NAA11 Gene

Gene Families for NAA11 Gene

HGNC:
  • NAA :N(alpha)-acetyltransferase subunits

Protein Domains for NAA11 Gene

Suggested Antigen Peptide Sequences for NAA11 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BSU3

UniProtKB/Swiss-Prot:

NAA11_HUMAN :
  • Q9BSU3
Domain:
  • Contains 1 N-acetyltransferase domain.
Family:
  • Belongs to the acetyltransferase family. ARD1 subfamily.
genes like me logo Genes that share domains with NAA11: view

Function for NAA11 Gene

Molecular function for NAA11 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA
UniProtKB/Swiss-Prot Function: Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.

Enzyme Numbers (IUBMB) for NAA11 Gene

Gene Ontology (GO) - Molecular Function for NAA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 peptide alpha-N-acetyltransferase activity IDA 16638120
GO:0005515 protein binding IPI 19480662
GO:0008080 N-acetyltransferase activity --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
GO:1990189 peptide-serine-N-acetyltransferase activity IBA --
genes like me logo Genes that share ontologies with NAA11: view

Phenotypes for NAA11 Gene

GenomeRNAi human phenotypes for NAA11:
genes like me logo Genes that share phenotypes with NAA11: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NAA11 Gene

Localization for NAA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAA11 Gene COMPARTMENTS Subcellular localization image for NAA11 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
golgi apparatus 4
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for NAA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0022626 cytosolic ribosome IBA --
GO:0031415 NatA complex IDA 16638120
genes like me logo Genes that share ontologies with NAA11: view

Pathways for NAA11 Gene

SuperPathways for NAA11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006474 N-terminal protein amino acid acetylation IDA 16638120
GO:0006475 internal protein amino acid acetylation IBA --
GO:0017198 N-terminal peptidyl-serine acetylation IBA --
GO:0018002 N-terminal peptidyl-glutamic acid acetylation IBA --
genes like me logo Genes that share ontologies with NAA11: view

No data available for Pathways by source for NAA11 Gene

Transcripts for NAA11 Gene

mRNA/cDNA for NAA11 Gene

(18) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NAA11 Gene

N(alpha)-acetyltransferase 11, NatA catalytic subunit:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAA11

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NAA11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAA11 Gene

No ASD Table

Relevant External Links for NAA11 Gene

GeneLoc Exon Structure for
NAA11
ECgene alternative splicing isoforms for
NAA11

Expression for NAA11 Gene

mRNA expression in normal human tissues for NAA11 Gene

mRNA differential expression in normal tissues according to GTEx for NAA11 Gene

This gene is overexpressed in Testis (34.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAA11 Gene

SOURCE GeneReport for Unigene cluster for NAA11 Gene Hs.676048

mRNA Expression by UniProt/SwissProt for NAA11 Gene

Q9BSU3-NAA11_HUMAN
Tissue specificity: Present in several cell lines, with highest levels in MCF-7 cells (at protein level).
genes like me logo Genes that share expressions with NAA11: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NAA11 Gene

Orthologs for NAA11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAA11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAA11 35
  • 99.42 (n)
  • 98.69 (a)
NAA11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAA11 35
  • 87.92 (n)
  • 90.39 (a)
NAA11 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAA11 35
  • 85.01 (n)
  • 86.03 (a)
NAA11 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm16286 36
  • 86 (a)
OneToMany
Naa11 35
  • 83.89 (n)
  • 86.73 (a)
Naa11 16
Naa11 36
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Naa11 35
  • 83.81 (n)
  • 87.5 (a)
zebrafish
(Danio rerio)
Actinopterygii naa10 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta vnc 36
  • 65 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K07H8.3 36
  • 66 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR409W 35
  • 57.32 (n)
  • 56.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARD1 35
  • 57.4 (n)
  • 59.6 (a)
ARD1 36
  • 41 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03367g 35
  • 55.85 (n)
  • 62.91 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G13780 35
  • 65.54 (n)
  • 68.24 (a)
rice
(Oryza sativa)
Liliopsida Os04g0635800 35
  • 62.69 (n)
  • 68.87 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08944 35
  • 61.39 (n)
  • 63.92 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes naa10 35
  • 62.12 (n)
  • 65.58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11133 36
  • 63 (a)
OneToMany
Species with no ortholog for NAA11:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAA11 Gene

ENSEMBL:
Gene Tree for NAA11 (if available)
TreeFam:
Gene Tree for NAA11 (if available)

Paralogs for NAA11 Gene

Paralogs for NAA11 Gene

Selected SIMAP similar genes for NAA11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NAA11: view

Variants for NAA11 Gene

Sequence variations from dbSNP and Humsavar for NAA11 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1385056 -- 79,317,539(+) GCAGC(A/G)TAGTG utr-variant-3-prime
rs1484147 -- 79,317,859(+) AAGAA(C/T)ACTGG intron-variant
rs3811765 - 79,325,862(-) GCAAC(A/G)CTCAG missense, reference
rs4473673 -- 79,319,589(+) TACTT(C/T)TGACA intron-variant
rs6818915 -- 79,327,759(+) AAAAT(G/T)AATTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NAA11 Gene

Variant ID Type Subtype PubMed ID
esv2727859 CNV Deletion 23290073
nsv879505 CNV Loss 21882294

Relevant External Links for NAA11 Gene

HapMap Linkage Disequilibrium report
NAA11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA11 Gene

Disorders for NAA11 Gene

No disorders were found for NAA11 Gene.

No data available for UniProtKB/Swiss-Prot for NAA11 Gene

Publications for NAA11 Gene

  1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B. … Sherman F. (BMC Proc. 2009) 2 3 4
  2. Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase. (PMID: 16638120) Arnesen T. … Lillehaug J.R. (BMC Biochem. 2006) 2 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1). (PMID: 19480662) Arnesen T. … Lillehaug J.R. (BMC Biochem. 2009) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for NAA11 Gene

Sources for NAA11 Gene

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