NAA11 Gene
protein-coding GIFtS: 41
GCID: GC04M080237
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N(alpha)-acetyltransferase 11, NatA catalytic subunit(Previous name: ARD1 homolog B (S. cerevisiae) )
(Previous symbol: ARD1B)
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Aliases
for NAA11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| N(Alpha)-Acetyltransferase 11, NatA Catalytic Subunit1 2 | | =N-Terminal Acetyltransferase Complex ARD1 Subunit Homolog B2 | | ARD1B1 2 3 | | ARD1 Homolog B2 | | ARD21 2 3 | | Human Arrest Defective 22 | | HARD21 | | N-Alpha-Acetyltransferase 112 | | NatA Catalytic Subunit2 3 | | N-Alpha-Acetyltransferase 11, NatA Catalytic Subunit2 | | N-Terminal Acetyltransferase Complex ARD1 Subunit Homolog B2 3 | | EC 2.3.1.883 | | ARD1 Homolog B (S. Cerevisiae)1 | | |
Export aliases for NAA11 gene to outside databasesPrevious GC identifer: GC04M075985 |
Summaries
for NAA11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NAA11_HUMAN, Q9BSU3Function: In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity
|
Genomic Views
for NAA11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for NAA11
Other transcription factors
Search SABiosciences Chromatin IP Primers for NAA11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAA11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q21.21 Ensembl cytogenetic band: 4q21.21 HGNC cytogenetic band: 4q21.23NAA11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M080237: view genomic region
(about GC identifiers)
Start:
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80,146,848 bp from pter |
End:
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80,247,204 bp from pter |
Size:
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100,357 bases |
Orientation:
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minus strand |
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Proteins
for NAA11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NAA11_HUMAN, Q9BSU3 (See
protein sequence)Recommended Name: N-alpha-acetyltransferase 11 Size: 229 amino acids; 25979 Da
Subunit: Interacts with NAA15 and HIF1A
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAH04552.2; Type=Erroneous initiation; Sequence=AAH63623.1; Type=Erroneous initiation;Sequence=AAH80651.1; Type=Erroneous initiation;
Secondary accessions: Q66K19 Q6P479Explore the universe of human proteins at neXtProt for NAA11: NX_Q9BSU3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BSU3
NAA11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_116082.1
ENSEMBL proteins: ENSP00000422022 ENSP00000286794
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
NAA11 for ontologies About GeneDecksing
NAA11 Antibody Products:
Assay Products for NAA11: |
Protein
Domains /
Families
for NAA11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NAA11 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BSU3ProtoNet protein and cluster: Q9BSU3 1 Blocks protein family: IPB000182 GCN5-related N-acetyltransferase
UniProtKB/Swiss-Prot: NAA11_HUMAN, Q9BSU3Similarity: Belongs to the acetyltransferase family. ARD1 subfamilySimilarity: Contains 1 N-acetyltransferase domain |
Function
for NAA11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NAA11_HUMAN, Q9BSU3Function: In complex with NAA15, displays alpha (N-terminal) acetyltransferase activityCatalytic activity: Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoAEnzyme Number (IUBMB): EC 2.3.1.881
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAA11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAA11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for NAA11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAA11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA11 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004596 | peptide alpha-N-acetyltransferase activity |
IEA | -- |
NAA11 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NAA11:
|
Pathways & Interactions
for NAA11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAA11
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/14 Interacting proteins for NAA11 (Q9BSU33 ENSP000002867944) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
|
Drugs & Compounds
for NAA11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NAA11
Search CenterWatch for drugs/clinical trials and news about NAA11
|
Transcripts
for NAA11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NAA11 gene: NM_032693.2 Unigene Cluster for NAA11: N(alpha)-acetyltransferase 11, NatA catalytic subunit Hs.676048 [show with all ESTs]Unigene Representative Sequence: BC0636233 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000511542 ENST00000513733 ENST00000286794(uc003hlt.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAA11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAA11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NAA11 (NM_032693) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NAA11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAA11 |
Additional cDNA sequence: BC004552.2 BC063623.1 BC080651.1 2 DOTS entries: DT.92070422 DT.100724808 18 AceView cDNA sequences: BE274897 BE894043 BC080651 BU188397 BC063623 BC004552 CR605070 BE274723 BX377969 BX359054 BG717714 BX398773 BX283809 BE408199 CB156091 BF125333 BX337855 BE728501
GeneLoc Exon Structure
|
Expression
for NAA11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NAA11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTCTTCCT
About this image
See NAA11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NAA11
SOURCE GeneReport for Unigene cluster: Hs.676048
UniProtKB/Swiss-Prot: NAA11_HUMAN, Q9BSU3Tissue specificity: Present in several cell lines, with highest levels in MCF-7 cells (at protein level)
SABiosciences Custom PCR Arrays for NAA11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAA11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NAA11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAA11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAA11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA11 |
Orthologs
for NAA11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NAA11 gene from 8/30 species (see all 30) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Naa111 , 5 |
N(alpha)-acetyltransferase 11, NatA catalytic subunit1, 5 |
84.56(n)1
87.16(a)1 |
|
5 (47.62 cM)5
972431 NM_001033191.21 NP_001028363.11
973822245 |
lizard
(Anolis carolinensis) |
Reptilia |
NAA106 |
-- |
71(a) |
1 → many |
2(88323375-88331609) |
zebrafish
(Danio rerio) |
Actinopterygii |
naa106 |
N(alpha)-acetyltransferase 10, NatA catalytic subu... |
73(a) |
1 → many |
23(13944337-13952423) |
fruit fly
(Drosophila melanogaster) |
Insecta |
vnc6 |
variable nurse cells |
66(a) |
1 → many |
3L(9965412-9967123) |
worm
(Caenorhabditis elegans) |
Secernentea |
K07H8.36 |
Protein K07H8.3 |
65(a) |
1 → many |
IV(8290253-8291485) |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
ARD11 |
Ard1p |
57.4(n)
59.6(a) |
|
856404 NP_011877.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G137806 |
peptide alpha-N-acetyltransferase |
55(a) |
1 → many |
5(4447259-4448646) |
rice
(Oryza sativa) |
Liliopsida |
-- |
acetyltransferase, GNAT family, putative, expresse... |
54(a) |
1 → many |
4(32153958-32157315) |
ENSEMBL Gene Tree for NAA11 (if available)
TreeFam Gene Tree for NAA11 (if available) |
Paralogs
for NAA11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NAA11 gene
- NAA102
2 SIMAP similar genes for NAA11 using alignment to 2 protein entries: NAA11_HUMAN (see all proteins):ARD1A NAA10
NAA11 for paralogs About GeneDecksing
|
Genomic Variants
for NAA11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAA11 |
|
Disorders
/ Diseases
for NAA11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NAA11 for disorders About GeneDecksing
8  diseases for NAA11: About MalaCardsfibrous histiocytoma cutaneous fibrous histiocytoma histiocytoma septic arthritis
hepatocellular carcinoma arthritis carcinoma malaria
Export disorders for NAA11 gene to outside databases
|
Publications
for NAA11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NAA11 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NAA11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PubMed id 19660095)1, 2, 3 Polevoda B.... Sherman F. (2009)
- Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase. (PubMed id 16638120)1, 2, 3 Arnesen T.... Lillehaug J.R. (2006)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Up-regulation of human arrest-defective 1 protein is c orrelated with metastatic phenotype and poor prognosis in breast cancer. (PubMed id 22292636)1 Wang Z.H....Tan D.Y. (2011)
- Expression of human NAA11 (ARD1B) gene is tissue-speci fic and is regulated by DNA methylation. (PubMed id 22048246)1 Pang A.L....Rennert O.M. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma. (PubMed id 20419844)1 Huang G.L....Wang H.Y. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for NAA11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NAA11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NAA11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAA11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NAA11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NAA11 gene:
Search GeneIP for patents involving NAA11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NAA11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NAA11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAA11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAA11 | | | OriGene Protein Over-expression Lysate for NAA11 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NAA11 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAA11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAA11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| |  |  |  |  | | | | |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA11 |
|  |  |  | | | | Search ThermoFisher Antibodies for NAA11 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAA11 |
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