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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NAA10 Gene

protein-coding   GIFtS: 60
GCID: GC0XM153194

N(Alpha)-Acetyltransferase 10, NatA Catalytic Subunit

(Previous names: ARD1 homolog, N-acetyltransferase (S. cerevisiae), ARD1...)
(Previous symbols: ARD1, ARD1A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
N(Alpha)-Acetyltransferase 10, NatA Catalytic Subunit1 2     NATD2
ARD1A1 2 3 5     ARD1 Homolog A, N-Acetyltransferase2
ARD11 2 3     N-Acetyltransferase ARD1, Human Homolog Of2
TE22 3     N-Alpha-Acetyltransferase 102
N-Terminal Acetyltransferase Complex ARD1 Subunit Homolog A2 3     N-Alpha-Acetyltransferase 10, NatA Catalytic Subunit2
DXS7072 5     EC 2.3.1.-3
ARD1 Homolog A, N-Acetyltransferase (S. Cerevisiae)1     EC 2.3.1.883
ARD1 Homolog, N-Acetyltransferase (S. Cerevisiae)1     NatA Catalytic Subunit3

External Ids:    HGNC: 187041   Entrez Gene: 82602   Ensembl: ENSG000001020307   OMIM: 3000135   UniProtKB: P412273   

Export aliases for NAA10 gene to outside databases

Previous GC identifer: GC0XM141848


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NAA10 Gene:
N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This
process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent
polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that
functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this
gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. (provided by
RefSeq, Jan 2012)

GeneCards Summary for NAA10 Gene: 
NAA10 (N(alpha)-acetyltransferase 10, NatA catalytic subunit) is a protein-coding gene. Diseases associated with NAA10 include ogden syndrome, and hypoxia. GO annotations related to this gene include acetyltransferase activity and ribosome binding. An important paralog of this gene is NAA11.

UniProtKB/Swiss-Prot: NAA10_HUMAN, P41227
Function: In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays
epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK
kinase activity by acetylation, and thus represses tumor cell migration

Gene Wiki entry for NAA10 (ARD1A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_167198.1  NC_018934.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NAA10
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAA10 promoter sequence
   Search SABiosciences Chromatin IP Primers for NAA10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAA10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

NAA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAA10 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM153194:  view genomic region     (about GC identifiers)

Start:
153,194,695 bp from pter      End:
153,200,676 bp from pter
Size:
5,982 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NAA10_HUMAN, P41227 (See protein sequence)
Recommended Name: N-alpha-acetyltransferase 10  
Size: 235 amino acids; 26459 Da
Subunit: Interacts with HIF1A (via its ODD domain); the interaction increases HIF1A protein stability during
normoxia, and down-regulates it when induced by hypoxia. Interacts with NAA15, NAA50 and with the ribosome. Binds
to MYLK. Associates with HYPK when in complex with NAA15
Subcellular location: Cytoplasm. Nucleus. Note=According to PubMed:12464182 it is cytoplasmic. According to
PubMed:15496142, it is nuclear and cytoplasmic. Also present in the free cytosolic and cytoskeleton-bound
polysomes
Secondary accessions: A6NM98
Alternative splicing: 2 isoforms:  P41227-1   P41227-2   

Explore the universe of human proteins at neXtProt for NAA10: NX_P41227

Explore proteomics data for NAA10 at MOPED 

Post-translational modifications:

  • UniProtKB: Cleaved by caspases during apoptosis
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P41227

  • NAA10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NAA10 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001243048.1  NP_001243049.1  NP_003482.1  

    ENSEMBL proteins: 
     ENSP00000417763   ENSP00000359032   ENSP00000377315   ENSP00000359026   ENSP00000359028  
     ENSP00000413668  

    Human Recombinant Protein Products for NAA10: 
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    Novus Biologicals NAA10 Proteins
    Novus Biologicals NAA10 Lysates
    Sino Biological Recombinant Protein for NAA10
    Sino Biological Cell Lysate for NAA10 
    ProSpec Recombinant Protein for NAA10
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005634nucleus IDA15496142
    GO:0005737cytoplasm IDA15496142

    NAA10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NAA: N(alpha)-acetyltransferase subunits

    2 InterPro protein domains:
     IPR000182 GNAT_dom
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry P41227

    ProtoNet protein and cluster: P41227

    1 Blocks protein domain: IPB000182 GCN5-related N-acetyltransferase

    UniProtKB/Swiss-Prot: NAA10_HUMAN, P41227
    Similarity: Belongs to the acetyltransferase family. ARD1 subfamily
    Similarity: Contains 1 N-acetyltransferase domain


    NAA10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAA10_HUMAN, P41227
    Function: In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays
    epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK
    kinase activity by acetylation, and thus represses tumor cell migration
    Catalytic activity: Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA

         Enzyme Numbers (IUBMB): EC 2.3.1.881 EC 2.3.1.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004596peptide alpha-N-acetyltransferase activity IEA--
    GO:0005515protein binding IPI15496142
    GO:0008080N-acetyltransferase activity TAS7981673
    GO:0016407contributes to acetyltransferase activity IDA15496142
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
         
    NAA10 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for NAA10:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Downregulation of NF-kappaB pa 
     Synthetic lethal with Ras 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NAA10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
    Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
    2Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for NAA10
        Chromatin Regulation / Acetylation

    1 BioSystems Pathway for NAA10
        Hypoxic and oxygen homeostasis regulation of HIF-1-alpha




    NAA10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAA10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/171 Interacting proteins for NAA10 (P412271, 2, 3 ENSP000004177634) via UniProtKB, MINT, STRING, and/or I2D (see all 171)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006323DNA packaging TAS7981673
    GO:0006474N-terminal protein amino acid acetylation IDA15496142
    GO:0006475internal protein amino acid acetylation TAS7981673

    NAA10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NAA10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NAA10

    1 Novoseek inferred chemical compound relationship for NAA10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 43 2 16376303 (1), 19090811 (1)

    Search CenterWatch for drugs/clinical trials and news about NAA10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NAA10 gene (3 alternative transcripts): 
    NM_001256119.1  NM_001256120.1  NM_003491.3  

    Unigene Cluster for NAA10:

    N(alpha)-acetyltransferase 10, NatA catalytic subunit
    Hs.433291  [show with all ESTs]
    Unigene Representative Sequence: AK296593
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464845(uc004fjm.1) ENST00000482485 ENST00000370015 ENST00000393712
    ENST00000370009(uc004fjn.1) ENST00000466877 ENST00000484950 ENST00000460996
    ENST00000370011 ENST00000467451 ENST00000432089 ENST00000477750(uc011mzg.1)
    ENST00000393710 ENST00000477882 ENST00000478177 ENST00000488481
    miRNA
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    Additional mRNA sequence: 

    AK294081.1 AK296593.1 AK309083.1 AK315997.1 AY183134.1 AY183135.1 BC000308.2 BC019312.1 
    BC063377.1 X77588.1 

    16 DOTS entries:

    DT.95176099  DT.315468  DT.100028961  DT.100796606  DT.92337079  DT.100796607  DT.75172251  DT.91751738 
    DT.121319502  DT.91677082  DT.121319504  DT.95176096  DT.95304160  DT.121319494  DT.95176097  DT.95176102 

    24/397 AceView cDNA sequences (see all 397):

    BE886449 AA532862 BU730738 BX353326 BQ931929 CA438229 AY183134 BM759805 
    CB161577 BC023626 AI188583 BU538872 AI873955 CA441579 AY183123 BI257855 
    CA487714 BQ684140 BQ898896 AW793245 CR591543 BQ066370 BQ434772 AY183135 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NAA10 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c
    SP1:                                      -                 -     -                 -           -     -                 -                     
    SP2:                                      -           -     -     -                 -           -     -                                       
    SP3:                                      -                 -     -                 -     -     -     -                 -                     
    SP4:                                      -                 -     -                             -     -                 -                     
    SP5:                                      -                 -     -                                                                           


    ECgene alternative splicing isoforms for NAA10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NAA10 expression in normal human tissues (normalized intensities)      NAA10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCGGGACC
    NAA10 Expression
    About this image


    NAA10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See NAA10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NAA10

    SOURCE GeneReport for Unigene cluster: Hs.433291

    UniProtKB/Swiss-Prot: NAA10_HUMAN, P41227
    Tissue specificity: Ubiquitous

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAA10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NAA10 gene from 9/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Naa101 , 5 N(alpha)-acetyltransferase 10, NatA catalytic subunitNalpha more1, 5 91.91(n)1
    96.17(a)1
      X (37.49 cM)5
    562921  NM_019870.31  NP_063923.11 
     739168735 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    84(a)
    1 → many
    2(88323375-88331609)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044094.12   -- 82.28(n)    BC044094.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc66b082 Danio rerio cDNA clone MGC63981 IMAGE6792376, complete more 78.13(n)    BC053180.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vnc1 variable nurse cells 76.43(n)
    80.25(a)
      39175  NM_168391.1  NP_729582.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K07H8.31 Protein K07H8.3 64.64(n)
    68.51(a)
      177622  NM_068991.3  NP_501392.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARD1(YHR013C)4 Subunit of N-terminal acetyltransferase NatA (Nat1p, more   --   8(131446-130730) 856404  NP_011877.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G137801 peptide alpha-N-acetyltransferase 64.41(n)
    67.57(a)
      831223  NM_121381.3  NP_196882.1 
    rice
    (Oryza sativa)
    Liliopsida Os.109712 Oryza sativa (japonica cultivar-group) cDNA clone0 more 76.12(n)    AK099507.1 


    ENSEMBL Gene Tree for NAA10 (if available)
    TreeFam Gene Tree for NAA10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NAA10 gene
    NAA112  
    4 SIMAP similar genes for NAA10 using alignment to 5 protein entries:     NAA10_HUMAN (see all proteins):
    ARD1A    NAA11    NAA20    NAA30

    NAA10 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NAA10
    PGOHUM00000250064


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/116 SNPs in NAA10 are shown (see all 116)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0666524
    N-terminal acetyltransferase deficiency (NATD)4--see VAR_0666522 S P mis40--------
    rs1875154761,2
    --153195080(+) ACCAAA/GAGTGG 3 -- ds50010--------
    rs1914759801,2
    --153195158(+) CAAGCA/CGACCT 3 -- ds50010--------
    rs1827998791,2
    --153195363(+) GCGCTC/TACACA 3 -- ut310--------
    rs20711281,2
    C,F,A,H--153195393(+) GGAGCG/AAATTT 3 -- ut3115Minor allele frequency- A:0.38NS EA NA 1861
    rs1490561241,2
    C--153195432(+) GATGGC/GGCAGG 3 -- ut310--------
    rs1509712161,2
    F--153195584(+) GAGCTC/TGGAGG 6 P syn11Minor allele frequency- T:0.00NA 4550
    rs2002063881,2
    --153195605(+) TTGCTC/TTCCAC 6 E syn10--------
    rs1408948711,2
    F--153195611(+) TCCACC/TTTGTT 6 K syn11Minor allele frequency- T:0.00NA 4552
    rs42435431,2
    C--153195884(+) CCCACA/GACAGA 3 -- int10--------

    HapMap Linkage Disequilibrium report for NAA10 (153194695 - 153200676 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NAA10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv33199CNV Gain+Loss17666407
    nsv469867CNV Complex16826518


    Human Gene Mutation Database (HGMD): NAA10
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NAA10
    DNA2.0 Custom Variant and Variant Library Synthesis for NAA10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300013    OMIM disorders: --

    UniProtKB/Swiss-Prot: NAA10_HUMAN, P41227
  • N-terminal acetyltransferase deficiency (NATD) [MIM:300855]: An enzymatic deficiency resulting in
    postnatal growth failure with severe delays and dysmorphic features. It is clinically characterized by wrinkled
    forehead, prominent eyes, widely opened anterior and posterior fontanels, downsloping palpebral fissures,
    thickened lids, large ears, flared nares, hypoplastic alae, short columella, protruding upper lip, and
    microretrognathia. There are also delayed closing of fontanels and broad great toes. Skin is characterized by
    redundancy or laxity with minimal subcutaneous fat, cutaneous capillary malformations, and very fine hair and
    eyebrows. Death results from cardiogenic shock following arrhythmia. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 9 diseases for NAA10:    About MalaCards
    ogden syndrome    hypoxia    esophageal cancer    esophagitis
    thyroiditis    colon cancer    neuronitis    breast cancer
    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for NAA10:
    Esophageal cancer     Squamous cell carcinoma

    NAA10 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for NAA10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 15994306 (2)

    Human Genome Epidemiology (HuGE) Navigator: NAA10 (0 documents)

    Export disorders for NAA10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NAA10 gene, integrated from 9 sources (see all 69):
    (articles sorted by number of sources associating them with NAA10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PubMed id 19660095)1, 2, 3 Polevoda B.... Sherman F. (2009)
    2. Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae. (PubMed id 7981673)1, 2, 3 Tribioli C.... Toniolo D. (1994)
    3. Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. (PubMed id 12464182)1, 2, 9 Jeong J.-W.... Kim K.-W. (2002)
    4. Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. (PubMed id 15496142)1, 2, 9 Arnesen T....Lillehaug J.R. (2005)
    5. Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency. (PubMed id 21700266)1, 2 Rope A.F.... Lyon G.J. (2011)
    6. The chaperone-like protein HYPK acts together with Na tA in cotranslational N-terminal acetylation and prevention of Huntingtin aggre gation. (PubMed id 20154145)1, 2 Arnesen T....Anderson D. (2010)
    7. Arrest defective-1 controls tumor cell behavior by ac etylating myosin light chain kinase. (PubMed id 19826488)1, 2 Shin D.H....Park J.W. (2009)
    8. Cloning and characterization of hNAT5/hSAN: an evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex. (PubMed id 16507339)1, 2 Arnesen T....Lillehaug J.R. (2006)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8260 HGNC: 18704 AceView: ARHGAP4andARD1 Ensembl:ENSG00000102030 euGenes: HUgn8260
    ECgene: NAA10 H-InvDB: NAA10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NAA10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NAA10 gene:
    Search GeneIP for patents involving NAA10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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