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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

N6AMT2 Gene

protein-coding   GIFtS: 47
GCID: GC13M021304

N-6 Adenine-Specific DNA Methyltransferase 2 (Putative)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
N-6 Adenine-Specific DNA Methyltransferase 2 (Putative)1 2
ESP132
N(6)-Adenine-Specific DNA Methyltransferase 22
EC 2.1.1.-3
EC 2.1.18

External Ids:    HGNC: 273511   Entrez Gene: 2211432   Ensembl: ENSG000001504567   UniProtKB: Q8WVE03   

Export aliases for N6AMT2 gene to outside databases

Previous GC identifers: GC13M020200 GC13M021296 GC13M002106


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for N6AMT2 Gene: 
N6AMT2 (N-6 adenine-specific DNA methyltransferase 2 (putative)) is a protein-coding gene. Diseases associated with N6AMT2 include otitis media. GO annotations related to this gene include methyltransferase activity and nucleic acid binding.

UniProtKB/Swiss-Prot: N6MT2_HUMAN, Q8WVE0
Function: Putative DNA methyltransferase (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the N6AMT2 gene promoter:
         AML1a   POU6F1 (c2)   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   YY1   FOXO4   FOXJ2 (long isoform)   FOXJ2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidN6AMT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for N6AMT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat N6AMT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.11   Ensembl cytogenetic band:  13q12.11   HGNC cytogenetic band: 13q12.11

N6AMT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
N6AMT2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M021304:  view genomic region     (about GC identifiers)

Start:
21,302,870 bp from pter      End:
21,348,097 bp from pter
Size:
45,228 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: N6MT2_HUMAN, Q8WVE0 (See protein sequence)
Recommended Name: N(6)-adenine-specific DNA methyltransferase 2  
Size: 214 amino acids; 24506 Da
Secondary accessions: B5G4V1

Explore the universe of human proteins at neXtProt for N6AMT2: NX_Q8WVE0

Explore proteomics data for N6AMT2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WVE0

  • 2 DME Specific Peptides for N6AMT2 (Q8WVE0)
     LLCTGAIME  SAPSVYQKL 

    N6AMT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    N6AMT2 Protein Expression
    REFSEQ proteins: NP_777588.1  
    ENSEMBL proteins: 
     ENSP00000372206   ENSP00000372202  

    Human Recombinant Protein Products for N6AMT2: 
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    Novus Biologicals N6AMT2 Protein
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    Cloud-Clone Corp. Proteins for N6AMT2 


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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR002052 DNA_methylase_N6_adenine_CS
     IPR019369 N6_adenine_Mtase-rel_euk

    Graphical View of Domain Structure for InterPro Entry Q8WVE0

    ProtoNet protein and cluster: Q8WVE0

    1 Blocks protein domain: IPB002052 N-6 Adenine-specific DNA methylase

    UniProtKB/Swiss-Prot: N6MT2_HUMAN, Q8WVE0
    Similarity: Belongs to the methyltransferase superfamily. AML1 family


    N6AMT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: N6MT2_HUMAN, Q8WVE0
    Function: Putative DNA methyltransferase (By similarity)

         Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.12

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008168methyltransferase activity IEA--
         
    N6AMT2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for N6AMT2:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for N6amt2):
     no phenotypic analysis 

    N6AMT2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for N6AMT2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for N6AMT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for N6AMT2 
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    miRNA
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for N6AMT2

    4 Interacting proteins for N6AMT2 (Q8WVE03) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KAT5Q929933I2D: score=1 
    MARK2Q7KZI73I2D: score=1 
    NARSO437763I2D: score=1 
    PRMT1Q998733I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for N6AMT2 (N6MT2)

    Search CenterWatch for drugs/clinical trials and news about N6AMT2 / N6MT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for N6AMT2 gene: 
    NM_174928.1  

    Unigene Cluster for N6AMT2:

    N-6 adenine-specific DNA methyltransferase 2 (putative)
    Hs.26674  [show with all ESTs]
    Unigene Representative Sequence: BG403594
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382758(uc009zzr.1 uc001unp.2) ENST00000382754(uc001uno.1)
    ENST00000460374
    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate N6AMT2
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat N6AMT2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat N6AMT2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat N6AMT2

    Additional mRNA sequence: 

    AK316604.1 BC018091.1 DQ823637.1 

    6 DOTS entries:

    DT.212371  DT.100020686  DT.120764848  DT.95215223  DT.86845889  DT.86849553 

    24/89 AceView cDNA sequences (see all 89):

    BE221713 AI085345 CA431429 AA328362 CA312613 AA705409 BX113581 AK055408 
    BF445318 AI755175 BU730996 AA292535 AI638452 CF454974 CB305681 CN479116 
    CR595343 CB242296 BM694587 AW295675 AA284407 AA742306 CB242633 AW450897 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for N6AMT2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:                                -               
    SP2:        -                                       
    SP3:                    -           -               
    SP4:        -           -                           


    ECgene alternative splicing isoforms for N6AMT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    N6AMT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGAACAGG
    N6AMT2 Expression
    About this image


    See N6AMT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for N6AMT2

    SOURCE GeneReport for Unigene cluster: Hs.26674
        SABiosciences Custom PCR Arrays for N6AMT2
    Primer
    Products:
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for N6AMT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for N6AMT2 gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia N6amt21 , 5 N-6 adenine-specific DNA methyltransferase 2 (putative)1, 5 80.82(n)1
    82.55(a)1
      14 (30.10 cM)5
    680431  NM_026526.21  NP_080802.11 
     575495985 
    chicken
    (Gallus gallus)
    Aves N6AMT21 N-6 adenine-specific DNA methyltransferase 2 (putative) 74(n)
    72.73(a)
      418951  NM_001006277.1  NP_001006277.1 
    lizard
    (Anolis carolinensis)
    Reptilia N6AMT26
    Uncharacterized protein
    67(a)
    1 ↔ 1
    3(187534926-187548136)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA974251.12   -- 77.06(n)    CA974251.1 
    zebrafish
    (Danio rerio)
    Actinopterygii n6amt21 N-6 adenine-specific DNA methyltransferase 2 (putative) 66.46(n)
    68.32(a)
      404619  NM_207087.1  NP_996970.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG91541 CG9154 51.3(n)
    43.52(a)
      33858  NM_135149.3  NP_608993.2 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_M142.81 Protein M142.8 54.79(n)
    48.51(a)
      176524  NM_001027523.2  NP_001022694.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YGR001C)4
    YGR001C1
    Putative protein of unknown function with similarity more4
    hypothetical protein1
    51.22(n)1
    42.93(a)1
      7(498034-497133)4
    8528841, 4  NP_011515.41  NP_011515.24 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G584701 nucleic acid binding / methyltransferase 53.11(n)
    45.45(a)
      825016  NM_115709.1  NP_567065.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07499001 hypothetical protein 48.09(n)
    45.77(a)
      4334118  NM_001057814.1  NP_001051279.1 


    ENSEMBL Gene Tree for N6AMT2 (if available)
    TreeFam Gene Tree for N6AMT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1046 SNPs in N6AMT2 are shown (see all 1046)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429897911,2
    --21302578(+) CACTCA/GTCCCA 1 -- int10--------
    rs1820510941,2
    --21302896(+) AAGGTC/TCTGTC 1 -- int10--------
    rs1869066931,2
    --21303077(+) AAGATC/TGCACA 1 -- ut310--------
    rs734352691,2
    C--21303144(+) TATAAC/TTTTTA 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs1901478511,2
    C--21303283(+) AGTTCC/TGGGTG 2 Q R mis10--------
    rs115498101,2,4
    C,H--21303286(+) TCCGGA/G/TTGTGT 3 N T I mis1 ese36NS EA NA 404
    rs2011912561,2
    C--21303335(+) TGCTGC/TCTGTT 2 T A mis11Minor allele frequency- T:0.00EU 1323
    rs784928971,2
    C,F--21303389(+) AGAGTG/TACAAC 1 -- int11Minor allele frequency- T:0.03WA 118
    rs286231761,2
    C--21303627(+) ATTATG/ACACAC 1 -- int11Minor allele frequency- A:0.50NA 2
    rs341782971,2
    C--21303627(+) TTATA-/AC/C  
            
    CACAC
    1 -- int10--------

    HapMap Linkage Disequilibrium report for N6AMT2 (21302870 - 21348097 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for N6AMT2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv951CNV Insertion18451855
    nsv832558CNV Loss17160897
    dgv6e24CNV Gain17666407

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for N6AMT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for N6AMT2:    About MalaCards
    otitis media    


    N6AMT2 for disorders           About GeneDecksing


    Export disorders for N6AMT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for N6AMT2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with N6AMT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcriptome analysis of a cDNA library from adult human epididymis. (PubMed id 18390568)1, 2 Li J.Y.... Zhang Y.L. (2008)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    5. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221143 HGNC: 27351 AceView: LOC221143 Ensembl:ENSG00000150456 euGenes: HUgn221143
    ECgene: N6AMT2 H-InvDB: N6AMT2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for N6AMT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for N6AMT2 gene:
    Search GeneIP for patents involving N6AMT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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