N6AMT2 Gene
protein-coding GIFtS: 45
GCID: GC13M021296
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N-6 adenine-specific DNA methyltransferase 2 (putative)
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Aliases
for N6AMT2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| N-6 Adenine-Specific DNA Methyltransferase 2 (Putative)1 2 | | ESP132 | | N(6)-Adenine-Specific DNA Methyltransferase 22 | | EC 2.1.1.-3 | | EC 2.1.18 |
Export aliases for N6AMT2 gene to outside databasesPrevious GC identifers: GC13M020200 GC13M002106 |
Summaries
for N6AMT2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: N6MT2_HUMAN, Q8WVE0Function: Putative DNA methyltransferase (By similarity)
|
Genomic Views
for N6AMT2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the N6AMT2 gene promoter:
AML1a POU6F1 (c2) POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 YY1 FOXO4 FOXJ2 (long isoform) FOXJ2 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for N6AMT2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat N6AMT2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q12.11 Ensembl cytogenetic band: 13q12.11 HGNC cytogenetic band: 13q12.11N6AMT2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M021296: view genomic region
(about GC identifiers)
Start:
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21,296,543 bp from pter |
End:
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21,348,097 bp from pter |
Size:
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51,555 bases |
Orientation:
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minus strand |
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Proteins
for N6AMT2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: N6MT2_HUMAN, Q8WVE0 (See
protein sequence)Recommended Name: N(6)-adenine-specific DNA methyltransferase 2 Size: 214 amino acids; 24506 Da
Secondary accessions: B5G4V1Explore the universe of human proteins at neXtProt for N6AMT2: NX_Q8WVE0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WVE0
2 DME Specific Peptides for N6AMT2 (Q8WVE0)
N6AMT2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_777588.1
ENSEMBL proteins: ENSP00000372206 ENSP00000372202
Human Recombinant Protein Products:
N6AMT2 Antibody Products:
Assay Products for N6AMT2: |
Protein
Domains /
Families
for N6AMT2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
N6AMT2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WVE0ProtoNet protein and cluster: Q8WVE0 1 Blocks protein family: IPB002052 N-6 Adenine-specific DNA methylase
UniProtKB/Swiss-Prot: N6MT2_HUMAN, Q8WVE0Similarity: Belongs to the methyltransferase superfamily. AML1 family |
Function
for N6AMT2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: N6MT2_HUMAN, Q8WVE0Function: Putative DNA methyltransferase (By similarity)Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.12
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for N6AMT2
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for N6AMT2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0008168 | methyltransferase activity |
IEA | -- |
N6AMT2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for N6AMT2:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for N6amt2):
N6AMT2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for N6AMT2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for N6AMT2
4 Interacting proteins for N6AMT2 (Q8WVE03) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for N6AMT2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for N6AMT2
Search CenterWatch for drugs/clinical trials and news about N6AMT2 / N6MT2
|
Transcripts
for N6AMT2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for N6AMT2 gene: NM_174928.1 Unigene Cluster for N6AMT2: N-6 adenine-specific DNA methyltransferase 2 (putative) Hs.26674 [show with all ESTs]Unigene Representative Sequence: BG4035944 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000473438(uc001unn.1) ENST00000382758(uc009zzr.1 uc001unp.2)
ENST00000382754(uc001uno.1) ENST00000460374
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for N6AMT2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for N6AMT2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: N6AMT2 (NM_174928) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for N6AMT2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat N6AMT2 |
Additional cDNA sequence: AK316604.1 BC018091.1 DQ823637.1 6 DOTS entries: DT.212371 DT.100020686 DT.120764848 DT.95215223 DT.86845889 DT.86849553 24/89 AceView cDNA sequences (see all 89): CF454974 AI669197 CR595343 AA328362 AA284407 CB242633 CB242296 CA431429 AA705409 AA292535 AW450897 BE221713 AK055408 AI085345 AA742306 BU730996 CN479116 CA312613 AI638452 BX113581 BM694587 BF445318 AI755175 AW295675
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for N6AMT2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
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| SP1: | | | | | | | | | | | - | | | | | | |
| SP2: | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | | | | | |
| SP4: | | | - | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for N6AMT2
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Expression
for N6AMT2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| N6AMT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGAACAGG
About this image
See N6AMT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for N6AMT2
SOURCE GeneReport for Unigene cluster: Hs.26674
SABiosciences Custom PCR Arrays for N6AMT2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for N6AMT2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat N6AMT2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat N6AMT2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat N6AMT2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for N6AMT2 |
Orthologs
for N6AMT2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for N6AMT2 gene from 10/28 species (see all 28) About this table
ENSEMBL Gene Tree for N6AMT2 (if available)
TreeFam Gene Tree for N6AMT2 (if available) |
Paralogs
for N6AMT2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for N6AMT2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for N6AMT2 (21296543 - 21348097 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for N6AMT2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing N6AMT2 |
|
Disorders
/ Diseases
for N6AMT2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
N6AMT2 for disorders About GeneDecksing
1  disease for N6AMT2: About MalaCardsotitis media
Export disorders for N6AMT2 gene to outside databases
|
Publications
for N6AMT2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for N6AMT2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with N6AMT2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Transcriptome analysis of a cDNA library from adult human epididymis. (PubMed id 18390568)1, 2 Li J.Y.... Zhang Y.L. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
|
External Searches for N6AMT2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing N6AMT2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing N6AMT2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing N6AMT2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for N6AMT2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for N6AMT2 gene:
Search GeneIP for patents involving N6AMT2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for N6AMT2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for N6AMT2 |
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