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Aliases for N6AMT2 Gene

Aliases for N6AMT2 Gene

  • N-6 Adenine-Specific DNA Methyltransferase 2 (Putative) 2 3
  • N(6)-Adenine-Specific DNA Methyltransferase 2 3 4
  • Protein-Lysine N-Methyltransferase N6AMT2 3
  • EC 2.1.1.- 4
  • EC 2.1.1 63
  • ESP13 3

External Ids for N6AMT2 Gene

Previous GeneCards Identifiers for N6AMT2 Gene

  • GC13M020200
  • GC13M021296
  • GC13M002106
  • GC13M021304
  • GC13M021308

Summaries for N6AMT2 Gene

GeneCards Summary for N6AMT2 Gene

N6AMT2 (N-6 Adenine-Specific DNA Methyltransferase 2 (Putative)) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and methyltransferase activity.

UniProtKB/Swiss-Prot for N6AMT2 Gene

  • S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for N6AMT2 Gene

Genomics for N6AMT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for N6AMT2 Gene

20,728,731 bp from pter
20,773,958 bp from pter
45,228 bases
Minus strand

Genomic View for N6AMT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for N6AMT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for N6AMT2 Gene

Proteins for N6AMT2 Gene

  • Protein details for N6AMT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein-lysine N-methyltransferase N6AMT2
    Protein Accession:
    Secondary Accessions:
    • B5G4V1

    Protein attributes for N6AMT2 Gene

    214 amino acids
    Molecular mass:
    24506 Da
    Quaternary structure:
    No Data Available

neXtProt entry for N6AMT2 Gene

Proteomics data for N6AMT2 Gene at MOPED

Selected DME Specific Peptides for N6AMT2 Gene

Post-translational modifications for N6AMT2 Gene

  • Ubiquitination at Lys88 and Lys164
  • Modification sites at PhosphoSitePlus

Other Protein References for N6AMT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for N6AMT2 Gene

Suggested Antigen Peptide Sequences for N6AMT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8WVE0
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
genes like me logo Genes that share domains with N6AMT2: view

No data available for Gene Families for N6AMT2 Gene

Function for N6AMT2 Gene

Molecular function for N6AMT2 Gene

UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.

Enzyme Numbers (IUBMB) for N6AMT2 Gene

Gene Ontology (GO) - Molecular Function for N6AMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with N6AMT2: view

Phenotypes for N6AMT2 Gene

MGI mutant phenotypes for N6AMT2:
inferred from 1 alleles
GenomeRNAi human phenotypes for N6AMT2:
genes like me logo Genes that share phenotypes with N6AMT2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for N6AMT2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for N6AMT2 Gene

Localization for N6AMT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for N6AMT2 Gene


Subcellular locations from

Jensen Localization Image for N6AMT2 Gene COMPARTMENTS Subcellular localization image for N6AMT2 gene
Compartment Confidence
cytosol 3
cytoskeleton 1
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for N6AMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with N6AMT2: view

Pathways for N6AMT2 Gene

SuperPathways for N6AMT2 Gene

No Data Available

Interacting Proteins for N6AMT2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000372202 Q8WVE0-N6MT2_HUMAN for N6AMT2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for N6AMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with N6AMT2: view

No data available for Pathways by source for N6AMT2 Gene

Transcripts for N6AMT2 Gene

mRNA/cDNA for N6AMT2 Gene

Unigene Clusters for N6AMT2 Gene

N-6 adenine-specific DNA methyltransferase 2 (putative):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for N6AMT2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for N6AMT2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for N6AMT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for N6AMT2 Gene

mRNA expression in normal human tissues for N6AMT2 Gene

Protein differential expression in normal tissues for N6AMT2 Gene

This gene is overexpressed in Lung (57.5) and Heart (11.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for N6AMT2 Gene

SOURCE GeneReport for Unigene cluster for N6AMT2 Gene Hs.26674

genes like me logo Genes that share expressions with N6AMT2: view

Expression partners for N6AMT2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for N6AMT2 Gene

Orthologs for N6AMT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for N6AMT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia N6AMT2 35
  • 76.48 (n)
  • 74.77 (a)
N6AMT2 36
  • 71 (a)
(Canis familiaris)
Mammalia N6AMT2 35
  • 86.41 (n)
  • 84.36 (a)
N6AMT2 36
  • 84 (a)
(Mus musculus)
Mammalia N6amt2 35
  • 80.82 (n)
  • 82.55 (a)
N6amt2 16
N6amt2 36
  • 78 (a)
(Pan troglodytes)
Mammalia N6AMT2 35
  • 99.38 (n)
  • 98.6 (a)
N6AMT2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia N6amt2 35
  • 80.97 (n)
  • 83.49 (a)
(Monodelphis domestica)
Mammalia N6AMT2 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia N6AMT2 36
  • 76 (a)
(Gallus gallus)
Aves N6AMT2 35
  • 74 (n)
  • 72.73 (a)
N6AMT2 36
  • 71 (a)
(Anolis carolinensis)
Reptilia N6AMT2 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia n6amt2 35
  • 69.35 (n)
  • 66.82 (a)
Str.20519 35
(Danio rerio)
Actinopterygii n6amt2 35
  • 66.46 (n)
  • 68.32 (a)
n6amt2 36
  • 66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5203 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010213 35
  • 52.24 (n)
  • 46.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9154 35
  • 51.99 (n)
  • 44.04 (a)
CG9154 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea CELE_M142.8 35
  • 54.58 (n)
  • 49.51 (a)
M142.8 36
  • 44 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL001W 35
  • 51.56 (n)
  • 42.86 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08712g 35
  • 50.32 (n)
  • 43.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YGR001C 35
  • 51.89 (n)
  • 44.33 (a)
-- 36
  • 36 (a)
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G58470 35
  • 53.11 (n)
  • 45.45 (a)
(Oryza sativa)
Liliopsida Os03g0749900 35
  • 48.09 (n)
  • 44.78 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02372 35
  • 50.25 (n)
  • 44.78 (a)
Species with no ortholog for N6AMT2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for N6AMT2 Gene

Gene Tree for N6AMT2 (if available)
Gene Tree for N6AMT2 (if available)

Paralogs for N6AMT2 Gene

No data available for Paralogs for N6AMT2 Gene

Variants for N6AMT2 Gene

Sequence variations from dbSNP and Humsavar for N6AMT2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs732414 -- 20,737,838(+) TTTTA(A/G)AACTG intron-variant
rs944053 -- 20,738,820(-) ATCCT(C/T)CCAAC intron-variant
rs944054 -- 20,738,627(-) ttgta(G/T)gggtg intron-variant
rs2243582 -- 20,731,014(+) aagaa(A/G)aaaca intron-variant
rs2248444 -- 20,753,587(-) tctga(G/T)gtata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for N6AMT2 Gene

Variant ID Type Subtype PubMed ID
nsv832558 CNV Loss 17160897
nsv951 CNV Insertion 18451855
dgv6e24 CNV Gain 17666407

Relevant External Links for N6AMT2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for N6AMT2 Gene

Disorders for N6AMT2 Gene

No disorders were found for N6AMT2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for N6AMT2 Gene

Publications for N6AMT2 Gene

  1. Transcriptome analysis of a cDNA library from adult human epididymis. (PMID: 18390568) Li J.Y. … Zhang Y.L. (DNA Res. 2008) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for N6AMT2 Gene

Sources for N6AMT2 Gene

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