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Aliases for N6AMT1 Gene

Aliases for N6AMT1 Gene

  • N-6 Adenine-Specific DNA Methyltransferase 1 (Putative) 2 3
  • N(6)-Adenine-Specific DNA Methyltransferase 1 3 4
  • HemK Methyltransferase Family Member 2 2 3
  • M.HsaHemK2P 3 4
  • C21orf127 3 4
  • HEMK2 3 4
  • Chromosome 21 Open Reading Frame 127 2
  • N6-DNA-Methyltransferase 3
  • EC 2.1.1.- 4
  • PRED28 3
  • N6AMT 3
  • MTQ2 3

External Ids for N6AMT1 Gene

Previous Symbols for N6AMT1 Gene

  • C21orf127
  • HEMK2

Summaries for N6AMT1 Gene

Entrez Gene Summary for N6AMT1 Gene

  • This gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing pf this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jul 2014]

GeneCards Summary for N6AMT1 Gene

N6AMT1 (N-6 Adenine-Specific DNA Methyltransferase 1 (Putative)) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and protein methyltransferase activity.

UniProtKB/Swiss-Prot for N6AMT1 Gene

  • Heterodimeric methyltransferase that catalyzes N5-methylation of ETF1 on Gln-185, using S-adenosyl L-methionine as methyl donor. ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May play a role in the modulation of arsenic-induced toxicity. May be involved in the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for N6AMT1 Gene

Genomics for N6AMT1 Gene

Genomic Location for N6AMT1 Gene

Start:
28,872,191 bp from pter
End:
28,885,373 bp from pter
Size:
13,183 bases
Orientation:
Minus strand

Genomic View for N6AMT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for N6AMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for N6AMT1 Gene

Regulatory Elements for N6AMT1 Gene

Proteins for N6AMT1 Gene

  • Protein details for N6AMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5N5-HEMK2_HUMAN
    Recommended name:
    HemK methyltransferase family member 2
    Protein Accession:
    Q9Y5N5
    Secondary Accessions:
    • Q96F73

    Protein attributes for N6AMT1 Gene

    Size:
    214 amino acids
    Molecular mass:
    22900 Da
    Quaternary structure:
    • Heterodimer with TRMT112

    Alternative splice isoforms for N6AMT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for N6AMT1 Gene

Proteomics data for N6AMT1 Gene at MOPED

Post-translational modifications for N6AMT1 Gene

No Post-translational modifications

Other Protein References for N6AMT1 Gene

No data available for DME Specific Peptides for N6AMT1 Gene

Domains for N6AMT1 Gene

Protein Domains for N6AMT1 Gene

Suggested Antigen Peptide Sequences for N6AMT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5N5

UniProtKB/Swiss-Prot:

HEMK2_HUMAN
Family:
  • Belongs to the eukaryotic/archaeal PrmC-related family.:
    • Q9Y5N5
genes like me logo Genes that share domains with N6AMT1: view

No data available for Gene Families for N6AMT1 Gene

Function for N6AMT1 Gene

Molecular function for N6AMT1 Gene

UniProtKB/Swiss-Prot Function: Heterodimeric methyltransferase that catalyzes N5-methylation of ETF1 on Gln-185, using S-adenosyl L-methionine as methyl donor. ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May play a role in the modulation of arsenic-induced toxicity. May be involved in the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid.

Enzyme Numbers (IUBMB) for N6AMT1 Gene

Gene Ontology (GO) - Molecular Function for N6AMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 18539146
GO:0008168 methyltransferase activity --
GO:0008276 protein methyltransferase activity IDA 18539146
genes like me logo Genes that share ontologies with N6AMT1: view
genes like me logo Genes that share phenotypes with N6AMT1: view

Animal Models for N6AMT1 Gene

MGI Knock Outs for N6AMT1:

miRNA for N6AMT1 Gene

miRTarBase miRNAs that target N6AMT1

No data available for Transcription Factor Targeting and HOMER Transcription for N6AMT1 Gene

Localization for N6AMT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for N6AMT1 Gene COMPARTMENTS Subcellular localization image for N6AMT1 gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for N6AMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0043234 protein complex IDA 18539146
genes like me logo Genes that share ontologies with N6AMT1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for N6AMT1 Gene

Pathways for N6AMT1 Gene

SuperPathways for N6AMT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for N6AMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation IEA --
GO:0030307 positive regulation of cell growth IDA 18539146
genes like me logo Genes that share ontologies with N6AMT1: view

No data available for Pathways by source for N6AMT1 Gene

Transcripts for N6AMT1 Gene

Unigene Clusters for N6AMT1 Gene

N-6 adenine-specific DNA methyltransferase 1 (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for N6AMT1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1:
SP2: -
SP3: -

Relevant External Links for N6AMT1 Gene

GeneLoc Exon Structure for
N6AMT1
ECgene alternative splicing isoforms for
N6AMT1

Expression for N6AMT1 Gene

mRNA expression in normal human tissues for N6AMT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for N6AMT1 Gene

SOURCE GeneReport for Unigene cluster for N6AMT1 Gene Hs.163846

mRNA Expression by UniProt/SwissProt for N6AMT1 Gene

Q9Y5N5-HEMK2_HUMAN
Tissue specificity: Widely expressed, with highest expression in parathyroid and pituitary glands, followed by adrenal gland and kidney, and lowest expression in leukocytes and mammary gland.
genes like me logo Genes that share expressions with N6AMT1: view

No data available for mRNA differential expression in normal tissues for N6AMT1 Gene

Orthologs for N6AMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for N6AMT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia N6AMT1 35
  • 98.75 (n)
  • 97.66 (a)
N6AMT1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC615200 35
  • 87.69 (n)
  • 90.19 (a)
N6AMT1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC487715 35
  • 89.25 (n)
  • 89.72 (a)
N6AMT1 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia N6amt1 35
  • 84.11 (n)
  • 86.92 (a)
N6amt1 16
N6amt1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia N6AMT1 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia N6amt1 35
  • 83.8 (n)
  • 88.32 (a)
chicken
(Gallus gallus)
Aves N6AMT1 35
  • 71.36 (n)
  • 71.83 (a)
N6AMT1 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia N6AMT1 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21286 35
tropical clawed frog
(Silurana tropicalis)
Amphibia n6amt1 35
  • 66.99 (n)
  • 71.36 (a)
zebrafish
(Danio rerio)
Actinopterygii n6amt1 35
  • 59.97 (n)
  • 62.68 (a)
n6amt1 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009458 35
  • 47.99 (n)
  • 46.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9960 35
  • 49.1 (n)
  • 41.87 (a)
CG9960 36
  • 38 (a)
OneToOne
snapin 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea C33C12.9 36
  • 41 (a)
OneToOne
CELE_C33C12.9 35
  • 50.09 (n)
  • 48.13 (a)
C33C12.9 37
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTQ2 36
  • 34 (a)
OneToOne
MTQ2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G13440 35
  • 48.56 (n)
  • 41.62 (a)
rice
(Oryza sativa)
Liliopsida Os03g0824200 35
  • 50.6 (n)
  • 44.04 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC323.05c 35
  • 47.09 (n)
  • 39.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for N6AMT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for N6AMT1 Gene

ENSEMBL:
Gene Tree for N6AMT1 (if available)
TreeFam:
Gene Tree for N6AMT1 (if available)

Paralogs for N6AMT1 Gene

Selected SIMAP similar genes for N6AMT1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for N6AMT1 Gene

genes like me logo Genes that share paralogs with N6AMT1: view

No data available for Paralogs for N6AMT1 Gene

Variants for N6AMT1 Gene

Sequence variations from dbSNP and Humsavar for N6AMT1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs15988 -- 28,872,478(+) GACCT(A/G)GGCAA nc-transcript-variant
rs876750 -- 28,886,913(-) TATAT(A/T)TTTCA upstream-variant-2KB
rs909350 -- 28,886,716(+) TCTTG(C/T)ATTTA upstream-variant-2KB
rs1048546 -- 28,872,555(-) AACAG(A/C)TAGCT nc-transcript-variant
rs1048547 -- 28,872,538(-) GAGAA(A/G)GGTGA nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for N6AMT1 Gene

Variant ID Type Subtype PubMed ID
nsv9862 CNV Gain 18304495
dgv1371e1 CNV Complex 17122850

Relevant External Links for N6AMT1 Gene

HapMap Linkage Disequilibrium report
N6AMT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for N6AMT1 Gene

Disorders for N6AMT1 Gene

Relevant External Links for N6AMT1

Genetic Association Database (GAD)
N6AMT1
Human Genome Epidemiology (HuGE) Navigator
N6AMT1
genes like me logo Genes that share disorders with N6AMT1: view

No data available for UniProtKB/Swiss-Prot for N6AMT1 Gene

Publications for N6AMT1 Gene

  1. HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1. (PMID: 18539146) Figaro S. … Heurgue-Hamard V. (FEBS Lett. 2008) 3 4 23
  2. Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity. (PMID: 21193388) Ren X. … Zhang L. (Environ. Health Perspect. 2011) 2 3 4
  3. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for N6AMT1 Gene

Sources for N6AMT1 Gene

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