N6AMT1 Gene
protein-coding GIFtS : 54
GC21M029166
N-6 adenine-specific DNA methyltransferase 1 (putative) (Previous names: chromosome 21 open reading frame 127, HemK methyltransferase family member 2 )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbols: C21orf127, HEMK2 )
Services
Jump to Section...
Aliases for N6AMT1
Databases for N6AMT1
Disorders for N6AMT1
Domains/Families for N6AMT1
Drugs/Compounds for N6AMT1
Expression for N6AMT1
Function for N6AMT1
Location for N6AMT1
Medical News for N6AMT1
Orthologs for N6AMT1
Paralogs for N6AMT1
Pathways/Interactions for N6AMT1
Proteins for N6AMT1
Publications for N6AMT1
SNPs for N6AMT1
Search Box for N6AMT1
Services for N6AMT1
Summaries for N6AMT1
Technologies for N6AMT1
Transcripts for N6AMT1
TOP
BOTTOM
Aliases & Descriptions for N6AMT1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Aliases C21orf127 2 , 3 EC 2.1.1.- 3 HEMK2 2 , 3 M.HsaHemK2P 3 MGC19995 2 MTQ2 1 , 2 N6-DNA-methyltransferase 2 N6AMT 1 , 2 OTTHUMP00000096393 2 OTTHUMP00000096394 2 PRED28 1 , 2
Descriptions HemK methyltransferase family member 2 1 , 2 , 3 N-6 adenine-specific DNA methyltransferase 1 2 N-6 adenine-specific DNA methyltransferase 1 (putative) 2 chromosome 21 open reading frame 127 1
Search outside databases for aliases for N6AMT1 genePrevious GC identifer: GC21M026827
Summaries for N6AMT1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
EntrezGene summary for N6AMT1 : The protein encoded by this gene belongs to the methyltransferase superfamily. Alternative splicingoccurs at this locus and two transcript variants encoding distinct isoforms have been identified.[provided by RefSeq]
Genomic Location for N6AMT1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 21q21.3 Ensembl cytogenetic band: 21q21.3 HGNC cytogenetic band: 21q21.3 N6AMT1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure
GeneLoc location for GC21M029166:
(about GC identifiers )
Start:
29,166,384 bp from pter
End:
29,179,564 bp from pter
Size:
13,181 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000021.7 NT_011512.10 Proteins for N6AMT1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
UniProtKB/Swiss-Prot: N6MT1_HUMAN, Q9Y5N5 (See
protein sequence )Recommended Name: N(6)-adenine-specific DNA methyltransferase 1 Size : 214 amino acids; 22901 Da
REFSEQ proteins (2 alternative transcripts):
NP_037372.2 NP_877426.2 ENSEMBL proteins: ENSP00000286764 ENSP00000303584 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: N6AMT1 Antibodies for N6AMT1: Assays for N6AMT1:
Protein
Domains/ Families for N6AMT1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Graphical View of Domain Structure for InterPro Entry Q9Y5N5 ProtoNet protein and cluster: Q9Y5N5
1 Blocks protein family : IPB002052 N-6 Adenine-specific DNA methylase UniProtKB/Swiss-Prot: N6MT1_HUMAN, Q9Y5N5 Similarity : Belongs to the hemK family
Gene Function for N6AMT1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_182749 Applied Biosystems Silencer ® siRNAs for N6AMT1 Sigma-Aldrich siRNA and siRNA Panels for N6AMT1 Sigma-Aldrich shRNA Panels and shRNA for N6AMT1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_013240                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_013240                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_013240  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_013240 3 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003676 nucleic acid binding
IEA -- GO:0008168 methyltransferase activity
IEA -- GO:0016740 transferase activity
IEA --
About this table
Pathways & Interactions for N6AMT1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
3 Interacting proteins for N6AMT1 (ENSP00000303584 3 Q9Y5N5 2 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0032259 methylation
IEA --
About this table
Drugs & Compounds for N6AMT1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Browse Tocris compounds for N6AMT1
Transcripts for N6AMT1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
OriGene , Expression Assays from Applied Biosystems )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_182749 Sigma-Aldrich siRNA and siRNA Panels for N6AMT1 Sigma-Aldrich shRNA Panels and shRNA for N6AMT1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_013240 NM_182749
REFSEQ mRNAs for N6AMT1 gene (2 alternative transcripts): NM_013240.3 NM_182749.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_013240 NM_182749
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_013240                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_013240                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_013240  
Additional cDNA sequence: AF139682.1 AK021678.1 AK225515.1 AK314100.1 BC011554.1 CR612892.1 CR616062.1 CR620576.1
4 DOTS entries : DT.91651052 DT.101976162 DT.100815348 DT.100832676
24/70 AceView cDNA sequences (see all 70
):CR616062 CR620576 BF026677 BE348272 Z40121 CR612892 AU118636 AI523341 F07022 NM_182749 AI424903 BU625644 AL520475 AI951414 BX281239 NM_013240 BX506362 AK092128 AL699341 BQ710426 AI311671 BU621448 BC011554 AL558133
highest scoring ESTs for N6AMT1 :AI421382 AL558133 AL699341 AU099867 AU280589 BC011554 BG477556 BI520047 BI520950 BM312701
Unigene Cluster for N6AMT1: N-6 adenine-specific DNA methyltransferase 1 (putative) Hs.163846 [show with all ESTs ] Unigene Representative Sequence: CR612892 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for N6AMT1 ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c SP1 :                     SP2 :           -           SP3 :           -          
About this scheme ECgene alternative splicing isoforms for N6AMT1 2 Ensembl transcripts including schematic representations : ENST00000351429
ENST00000303775
Expression for N6AMT1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
N6AMT1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for N6AMT1 1 / 2 / 3
7 probe-sets matching N6AMT1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AAGGACCCCTSOURCE GeneReport for Unigene cluster: Hs.163846
Orthologs for N6AMT1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Orthologs for N6AMT1 gene from 5/15 species (see all 15
)
About this table Species with no ortholog for N6AMT1 ENSEMBL Gene Tree for N6AMT1 Paralogs for N6AMT1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Pseudogenes 1 related pseudogene
SNPs/Variants for N6AMT1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
HapMap Linkage Disequilibrium images for N6AMT1 (up to first 250kb)
Disorders & Mutations for N6AMT1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
--
Medical News for N6AMT1 (Possibly Related Articles in
Doctor's Guide )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
--
Publications for N6AMT1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
7 PubMed articles for N6AMT1 gene :
Search for N6AMT1
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Genome Databases showing N6AMT1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Other Databases showing N6AMT1
(According to HUGE )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
--
Specialized Databases showing N6AMT1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
-- Services for N6AMT1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Products for N6AMT1:
Search Tocris compounds for N6AMT1
Jump to Section...
Aliases for N6AMT1
Databases for N6AMT1
Disorders for N6AMT1
Domains/Families for N6AMT1
Drugs/Compounds for N6AMT1
Expression for N6AMT1
Function for N6AMT1
Location for N6AMT1
Medical News for N6AMT1
Orthologs for N6AMT1
Paralogs for N6AMT1
Pathways/Interactions for N6AMT1
Proteins for N6AMT1
Publications for N6AMT1
SNPs for N6AMT1
Search Box for N6AMT1
Services for N6AMT1
Summaries for N6AMT1
Technologies for N6AMT1
Transcripts for N6AMT1
TOP
BOTTOM
GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009