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Aliases for N4BP3 Gene

Aliases for N4BP3 Gene

  • NEDD4 Binding Protein 3 2 3 5
  • NEDD4-Binding Protein 3 3
  • KIAA0341 4
  • LZTS4 3

External Ids for N4BP3 Gene

Previous GeneCards Identifiers for N4BP3 Gene

  • GC05P177695
  • GC05P178427
  • GC05P177608
  • GC05P177654
  • GC05P177473
  • GC05P177540
  • GC05P172272

Summaries for N4BP3 Gene

GeneCards Summary for N4BP3 Gene

N4BP3 (NEDD4 Binding Protein 3) is a Protein Coding gene. An important paralog of this gene is LZTS2.

Additional gene information for N4BP3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for N4BP3 Gene

Genomics for N4BP3 Gene

Regulatory Elements for N4BP3 Gene

Enhancers for N4BP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H178111 2 FANTOM5 Ensembl ENCODE dbSUPER 18.7 +6.7 6675 16.8 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZBTB7B ZNF766 ZNF143 ZNF207 NSD1 ENSG00000247679 ZNF879 ZNF354B LOC202181 CLK4 ZNF354C N4BP3 FAM193B RMND5B
GH05H178086 1.1 ENCODE dbSUPER 12.8 -26.9 -26930 0.7 GTF2F1 HDGF PKNOX1 NFIB SIN3A ZBTB7B RFX5 E2F1 CTBP1 ZNF316 N4BP3 RMND5B FAM153C RPL19P9 LOC105377754 PIR41367
GH05H178077 1.1 Ensembl ENCODE 12.5 -35.0 -35037 1.2 HDGF PKNOX1 NFIB SIN3A ZBTB7B EGR1 FOS RCOR1 SMARCA5 HCFC1 NSD1 CLK4 FAM193B ZNF354B RMND5B N4BP3 LOC202181 HNRNPAB RPL21P60 ENSG00000247679
GH05H178079 0.9 ENCODE 12.5 -32.4 -32442 2.9 HDGF NFIB SIN3A YBX1 ZBTB40 ZNF766 HSF1 FOS RCOR1 SMARCA5 RMND5B N4BP3 CLK4 RPL19P9 LOC105377754 PIR41367
GH05H178090 0.7 dbSUPER 12.8 -22.5 -22455 0.6 SIX4 GTF2F1 ESRRA NFIB BATF GATA3 FOSL2 FOS TCF7L2 SMARCA5 N4BP3 RMND5B FAM153C LOC105377754 PIR41367
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around N4BP3 on UCSC Golden Path with GeneCards custom track

Promoters for N4BP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000191401 357 1201 HDGF ARNT SIN3A ZBTB7B ZNF766 GLIS2 ELK1 ZNF143 FOS ATF7

Genomic Locations for N4BP3 Gene

Genomic Locations for N4BP3 Gene
13,592 bases
Plus strand

Genomic View for N4BP3 Gene

Genes around N4BP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
N4BP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for N4BP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for N4BP3 Gene

Proteins for N4BP3 Gene

  • Protein details for N4BP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NEDD4-binding protein 3
    Protein Accession:
    Secondary Accessions:
    • B4DIL3
    • D3DWP3
    • Q6ZSQ6
    • Q7Z6I3

    Protein attributes for N4BP3 Gene

    544 amino acids
    Molecular mass:
    60470 Da
    Quaternary structure:
    • Binds NEDD4. Interacts with 14-3-3 proteins.
    • Sequence=BAA20799.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC86891.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86891.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAG58525.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for N4BP3 Gene

Post-translational modifications for N4BP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for N4BP3 Gene

No data available for DME Specific Peptides for N4BP3 Gene

Domains & Families for N4BP3 Gene

Gene Families for N4BP3 Gene

Protein Domains for N4BP3 Gene


Suggested Antigen Peptide Sequences for N4BP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with N4BP3: view

No data available for UniProtKB/Swiss-Prot for N4BP3 Gene

Function for N4BP3 Gene

Gene Ontology (GO) - Molecular Function for N4BP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11717310
genes like me logo Genes that share ontologies with N4BP3: view
genes like me logo Genes that share phenotypes with N4BP3: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for N4BP3 Gene

Localization for N4BP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for N4BP3 Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for N4BP3 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for N4BP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with N4BP3: view

Pathways & Interactions for N4BP3 Gene

SuperPathways for N4BP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for N4BP3 Gene


No data available for Pathways by source and SIGNOR curated interactions for N4BP3 Gene

Drugs & Compounds for N4BP3 Gene

No Compound Related Data Available

Transcripts for N4BP3 Gene

mRNA/cDNA for N4BP3 Gene

Unigene Clusters for N4BP3 Gene

NEDD4 binding protein 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for N4BP3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5

Relevant External Links for N4BP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for N4BP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for N4BP3 Gene

mRNA differential expression in normal tissues according to GTEx for N4BP3 Gene

This gene is overexpressed in Esophagus - Mucosa (x7.2).

Protein differential expression in normal tissues from HIPED for N4BP3 Gene

This gene is overexpressed in Placenta (36.2) and Heart (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for N4BP3 Gene

Protein tissue co-expression partners for N4BP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of N4BP3 Gene:


SOURCE GeneReport for Unigene cluster for N4BP3 Gene:


Evidence on tissue expression from TISSUES for N4BP3 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with N4BP3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for N4BP3 Gene

Orthologs for N4BP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for N4BP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia N4BP3 34 33
  • 99.33 (n)
(Bos Taurus)
Mammalia N4BP3 33 34
  • 89.9 (n)
(Canis familiaris)
Mammalia N4BP3 34 33
  • 87.74 (n)
(Rattus norvegicus)
Mammalia N4bp3 33
  • 87.15 (n)
(Mus musculus)
Mammalia N4bp3 33 16 34
  • 86.72 (n)
(Ornithorhynchus anatinus)
Mammalia N4BP3 34
  • 56 (a)
(Monodelphis domestica)
Mammalia N4BP3 34
  • 40 (a)
(Gallus gallus)
Aves N4BP3 33 34
  • 63.27 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
-- 34
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia n4bp3 33
  • 53.47 (n)
(Danio rerio)
Actinopterygii LOC101884870 33
  • 52.89 (n)
N4BP3 34
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3837 34
  • 28 (a)
Species where no ortholog for N4BP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for N4BP3 Gene

Gene Tree for N4BP3 (if available)
Gene Tree for N4BP3 (if available)

Paralogs for N4BP3 Gene

Paralogs for N4BP3 Gene

genes like me logo Genes that share paralogs with N4BP3: view

Variants for N4BP3 Gene

Sequence variations from dbSNP and Humsavar for N4BP3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000208965 -- 178,122,421(+) TACGC(C/T)GAGCC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000385296 -- 178,119,930(+) CCCAT(A/G)CCCCT intron-variant
rs1000445217 -- 178,116,898(+) TAAGC(C/T)CTTTC intron-variant
rs1000448739 -- 178,114,260(+) TTCAC(C/T)CCTGC intron-variant
rs1000543544 -- 178,115,866(+) ATTCC(A/G)GTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for N4BP3 Gene

Variant ID Type Subtype PubMed ID
nsv950731 CNV deletion 24416366
nsv950730 CNV deletion 24416366
nsv600394 CNV loss 21841781
nsv600392 CNV loss 21841781
nsv600391 CNV loss 21841781
nsv471058 CNV loss 18288195
nsv462567 CNV loss 19166990
nsv1144125 CNV deletion 24896259
nsv1120062 OTHER inversion 24896259
nsv1019404 CNV gain 25217958
dgv5844n100 CNV gain 25217958

Variation tolerance for N4BP3 Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for N4BP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for N4BP3 Gene

Disorders for N4BP3 Gene

Relevant External Links for N4BP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for N4BP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for N4BP3 Gene

Publications for N4BP3 Gene

  1. Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. (PMID: 11717310) Murillas R … Kuehn MR (The Journal of biological chemistry 2002) 2 3 4 60
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 60
  3. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. (PMID: 15324660) Jin J … Pawson T (Current biology : CB 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for N4BP3 Gene

Sources for N4BP3 Gene

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