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Aliases for N4BP3 Gene

Aliases for N4BP3 Gene

  • NEDD4 Binding Protein 3 2 3
  • NEDD4-Binding Protein 3 3
  • KIAA0341 4
  • LZTS4 3

External Ids for N4BP3 Gene

Previous GeneCards Identifiers for N4BP3 Gene

  • GC05P177695
  • GC05P178427
  • GC05P177608
  • GC05P177654
  • GC05P177473
  • GC05P177540
  • GC05P172272

Summaries for N4BP3 Gene

GeneCards Summary for N4BP3 Gene

N4BP3 (NEDD4 Binding Protein 3) is a Protein Coding gene. An important paralog of this gene is LZTS2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for N4BP3 Gene

Genomics for N4BP3 Gene

Regulatory Elements for N4BP3 Gene

Genomic Location for N4BP3 Gene

Start:
178,113,443 bp from pter
End:
178,126,106 bp from pter
Size:
12,664 bases
Orientation:
Plus strand

Genomic View for N4BP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for N4BP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for N4BP3 Gene

Proteins for N4BP3 Gene

  • Protein details for N4BP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15049-N4BP3_HUMAN
    Recommended name:
    NEDD4-binding protein 3
    Protein Accession:
    O15049
    Secondary Accessions:
    • B4DIL3
    • D3DWP3
    • Q6ZSQ6
    • Q7Z6I3

    Protein attributes for N4BP3 Gene

    Size:
    544 amino acids
    Molecular mass:
    60470 Da
    Quaternary structure:
    • Binds NEDD4. Interacts with 14-3-3 proteins.
    SequenceCaution:
    • Sequence=BAA20799.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC86891.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86891.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAG58525.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for N4BP3 Gene

Proteomics data for N4BP3 Gene at MOPED

Post-translational modifications for N4BP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for N4BP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for N4BP3 Gene

Domains for N4BP3 Gene

Protein Domains for N4BP3 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for N4BP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with N4BP3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for N4BP3 Gene

Function for N4BP3 Gene

Gene Ontology (GO) - Molecular Function for N4BP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with N4BP3: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for N4BP3 Gene

Localization for N4BP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for N4BP3 Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for N4BP3 Gene COMPARTMENTS Subcellular localization image for N4BP3 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for N4BP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with N4BP3: view

Pathways for N4BP3 Gene

SuperPathways for N4BP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for N4BP3 Gene

None

No data available for Pathways by source for N4BP3 Gene

Transcripts for N4BP3 Gene

mRNA/cDNA for N4BP3 Gene

Unigene Clusters for N4BP3 Gene

NEDD4 binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for N4BP3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5
SP1:
SP2:

Relevant External Links for N4BP3 Gene

GeneLoc Exon Structure for
N4BP3
ECgene alternative splicing isoforms for
N4BP3

Expression for N4BP3 Gene

mRNA expression in normal human tissues for N4BP3 Gene

mRNA differential expression in normal tissues according to GTEx for N4BP3 Gene

This gene is overexpressed in Esophagus - Mucosa (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for N4BP3 Gene

SOURCE GeneReport for Unigene cluster for N4BP3 Gene Hs.101761

genes like me logo Genes that share expressions with N4BP3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for N4BP3 Gene

Orthologs for N4BP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for N4BP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia N4BP3 35
  • 99.33 (n)
  • 99.45 (a)
N4BP3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia N4BP3 35
  • 89.9 (n)
  • 92.61 (a)
N4BP3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia N4BP3 35
  • 87.74 (n)
  • 89.65 (a)
N4BP3 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia N4bp3 35
  • 86.72 (n)
  • 91.99 (a)
N4bp3 16
N4bp3 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia N4BP3 36
  • 40 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia N4BP3 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia N4bp3 35
  • 87.15 (n)
  • 92.18 (a)
chicken
(Gallus gallus)
Aves N4BP3 35
  • 63.27 (n)
  • 52.41 (a)
N4BP3 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia n4bp3 35
  • 53.47 (n)
  • 45.77 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101884870 35
  • 52.89 (n)
  • 45.23 (a)
N4BP3 36
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3837 36
  • 28 (a)
OneToMany
Species with no ortholog for N4BP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for N4BP3 Gene

ENSEMBL:
Gene Tree for N4BP3 (if available)
TreeFam:
Gene Tree for N4BP3 (if available)

Paralogs for N4BP3 Gene

Paralogs for N4BP3 Gene

genes like me logo Genes that share paralogs with N4BP3: view

Variants for N4BP3 Gene

Sequence variations from dbSNP and Humsavar for N4BP3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs3812072 -- 178,125,222(-) GGACC(A/G)AGGGC utr-variant-3-prime
rs3812073 -- 178,124,984(-) GCTGT(A/G)GTGAA utr-variant-3-prime
rs3812074 -- 178,124,175(-) ATACC(A/G)AGGTG utr-variant-3-prime
rs3812075 -- 178,124,168(-) GGTGG(A/G)CCCTG utr-variant-3-prime
rs3812076 -- 178,124,153(-) CAGGT(A/G)TGTGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for N4BP3 Gene

Variant ID Type Subtype PubMed ID
nsv883186 CNV Gain 21882294
nsv462567 CNV Loss 19166990
nsv471058 CNV Loss 18288195
nsv883190 CNV Loss 21882294
nsv883191 CNV Loss 21882294
nsv883192 CNV Loss 21882294

Relevant External Links for N4BP3 Gene

HapMap Linkage Disequilibrium report
N4BP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for N4BP3 Gene

Disorders for N4BP3 Gene

No disorders were found for N4BP3 Gene.

No data available for UniProtKB/Swiss-Prot for N4BP3 Gene

Publications for N4BP3 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. (PMID: 11717310) Murillas R. … Kuehn M.R. (J. Biol. Chem. 2002) 2 3 4
  3. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. (PMID: 15324660) Jin J. … Pawson T. (Curr. Biol. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3

Products for N4BP3 Gene

Sources for N4BP3 Gene

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