N4BP3 Gene
protein-coding GIFtS: 44
GCID: GC05P177540
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NEDD4 binding protein 3
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Aliases
for N4BP3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NEDD4 Binding Protein 31 2 | | LZTS41 2 | | NEDD4-Binding Protein 32 | | KIAA03413 |
Export aliases for N4BP3 gene to outside databasesPrevious GC identifers: GC05P177695 GC05P178427 GC05P177608 GC05P177654 GC05P177473 GC05P172272 |
Summaries
for N4BP3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for N4BP3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the N4BP3 gene promoter:
Max1 SREBP-1c COUP SREBP-1b HEN1 FAC1 COUP-TF SREBP-1a HSF2 ZIC2/Zic2
Other transcription factors
Search SABiosciences Chromatin IP Primers for N4BP3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat N4BP3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3N4BP3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P177540: view genomic region
(about GC identifiers)
Start:
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177,540,444 bp from pter |
End:
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177,553,107 bp from pter |
Size:
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12,664 bases |
Orientation:
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plus strand |
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Proteins
for N4BP3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: N4BP3_HUMAN, O15049 (See
protein sequence)Recommended Name: NEDD4-binding protein 3 Size: 544 amino acids; 60470 Da
Subunit: Binds NEDD4. Interacts with 14-3-3 proteins
Subcellular location: Cytoplasmic vesicle membrane; Peripheral membrane protein
Sequence caution: Sequence=BAA20799.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=BAC86891.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC86891.1;Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=BAG58525.1; Type=Erroneous initiation;Note=Translation N-terminally extended;
Secondary accessions: B4DIL3 D3DWP3 Q6ZSQ6 Q7Z6I3Explore the universe of human proteins at neXtProt for N4BP3: NX_O15049
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15049
N4BP3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055926.1
ENSEMBL proteins: ENSP00000274605
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030659 | cytoplasmic vesicle membrane |
IEA | -- |
N4BP3 for ontologies About GeneDecksing
N4BP3 Antibody Products:
Assay Products for N4BP3: |
Protein
Domains /
Families
for N4BP3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
N4BP3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O15049ProtoNet protein and cluster: O15049 |
Function
for N4BP3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for N4BP3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for N4BP3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for N4BP3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat N4BP3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for N4BP3 |
|
Pathways & Interactions
for N4BP3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for N4BP3
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for N4BP3 (O150492, 3 ENSP000002746054) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for N4BP3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for N4BP3
Search CenterWatch for drugs/clinical trials and news about N4BP3
|
Transcripts
for N4BP3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for N4BP3 gene: NM_015111.1 Unigene Cluster for N4BP3: NEDD4 binding protein 3 Hs.101761 [show with all ESTs]Unigene Representative Sequence: NM_0151111 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000274605(uc003mik.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for N4BP3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for N4BP3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: N4BP3 (NM_015111) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for N4BP3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat N4BP3 |
Additional cDNA sequence: AB002339.1 AK127224.1 AK295663.1 BC027715.2 BC053323.1 4 DOTS entries: DT.407217 DT.99951796 DT.99939699 DT.100689194 24/40 AceView cDNA sequences (see all 40): CA946541 AA372485 BX391050 BC053323 BU557397 BU538610 CR613906 BC027715 AB002339 CD109989 CB989360 AL583320 AK127224 BE791648 BE378392 BF309170 CD673795 AW139448 AA361587 AW083116 AL551198 AL551173 BX505754 AA829496
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for N4BP3 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 |
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| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for N4BP3
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Expression
for N4BP3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| N4BP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTCTAAAA
About this image
See N4BP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for N4BP3
SOURCE GeneReport for Unigene cluster: Hs.101761
SABiosciences Custom PCR Arrays for N4BP3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for N4BP3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat N4BP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat N4BP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat N4BP3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for N4BP3 |
Orthologs
for N4BP3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for N4BP3 gene from 5/12 species (see all 12) About this table
ENSEMBL Gene Tree for N4BP3 (if available)
TreeFam Gene Tree for N4BP3 (if available) |
Paralogs
for N4BP3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for N4BP3 gene
- PROSAPIP12 LZTS12 LZTS22
N4BP3 for paralogs About GeneDecksing
|
Genomic Variants
for N4BP3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for N4BP3 (177540444 - 177553107 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for N4BP3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing N4BP3 |
|
Disorders
/ Diseases
for N4BP3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for N4BP3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for N4BP3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with N4BP3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. (PubMed id 11717310)1, 2, 3 Murillas R.... Kuehn M.R. (2002)
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
- Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. (PubMed id 15324660)1, 2 Jin J....Pawson T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for N4BP3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing N4BP3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing N4BP3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing N4BP3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for N4BP3 gene:
Search GeneIP for patents involving N4BP3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for N4BP3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for N4BP3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for N4BP3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for N4BP3 | | | OriGene Protein Over-expression Lysate for N4BP3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for N4BP3 | | OriGene 3'-UTR Clone for N4BP3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for N4BP3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for N4BP3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for N4BP3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat N4BP3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing N4BP3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat N4BP3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat N4BP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat N4BP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat N4BP3 |
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 | | | N4BP3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for N4BP3 |
|  |  |  | | | | ThermoFisher Antibodies for N4BP3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat N4BP3 |
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