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Aliases for N4BP2L2 Gene

Aliases for N4BP2L2 Gene

  • NEDD4 Binding Protein 2 Like 2 2 3 5
  • Phosphonoformate Immuno-Associated Protein 5 2 3 4
  • PFAAP5 3 4
  • CG005 3 4
  • NEDD4-Binding Protein 2-Like 2 3
  • Protein From BRCA2 Region 3
  • 92M18.3 3
  • CG016 3

External Ids for N4BP2L2 Gene

Previous GeneCards Identifiers for N4BP2L2 Gene

  • GC13M031891
  • GC13M033007
  • GC13M013818

Summaries for N4BP2L2 Gene

GeneCards Summary for N4BP2L2 Gene

N4BP2L2 (NEDD4 Binding Protein 2 Like 2) is a Protein Coding gene. GO annotations related to this gene include enzyme binding and RNA polymerase II transcription corepressor activity. An important paralog of this gene is N4BP2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for N4BP2L2 Gene

Genomics for N4BP2L2 Gene

Regulatory Elements for N4BP2L2 Gene

Enhancers for N4BP2L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G033270 1.8 FANTOM5 Ensembl ENCODE dbSUPER 31.7 -739.7 -739696 16.6 PKNOX1 FOXA2 ZNF133 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF48 YY1 N4BP2L2 STARD13-AS RFC3 KL STARD13 LINC02344
GH13G032968 1.4 Ensembl ENCODE 11.6 -430.8 -430810 2.1 HDGF FOXA2 CREB3L1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 YY1 RFC3 N4BP2L2 KL TOMM22P3
GH13G032425 1.3 ENCODE dbSUPER 10.7 +110.8 110814 4.9 HDGF HNRNPUL1 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ENSG00000212293 N4BP2L2 PDS5B N4BP2L1 GC13M032421
GH13G032471 1.1 Ensembl ENCODE 11.2 +66.9 66922 1.8 PKNOX1 PTBP1 TCF12 GATA2 EGR1 EGR2 CREB3 NFIC SMARCA4 KLF16 N4BP2L2 N4BP2L1 ENSG00000212293 PDS5B ATP8A2P2 ENSG00000270008
GH13G032045 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.3 +491.8 491785 2.6 ELF3 TBP NFIB ARID4B FEZF1 YY1 SCRT2 CREM MIXL1 THAP11 FRY FRY-AS1 N4BP2L2 N4BP2L1 BRCA2 GC13P032060
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around N4BP2L2 on UCSC Golden Path with GeneCards custom track

Promoters for N4BP2L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000060911 385 2200 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143

Genomic Location for N4BP2L2 Gene

32,432,417 bp from pter
32,538,885 bp from pter
106,469 bases
Minus strand

Genomic View for N4BP2L2 Gene

Genes around N4BP2L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
N4BP2L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for N4BP2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for N4BP2L2 Gene

Proteins for N4BP2L2 Gene

  • Protein details for N4BP2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NEDD4-binding protein 2-like 2
    Protein Accession:
    Secondary Accessions:
    • A3KME8

    Protein attributes for N4BP2L2 Gene

    583 amino acids
    Molecular mass:
    67459 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI31632.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BP361938; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for N4BP2L2 Gene


neXtProt entry for N4BP2L2 Gene

Post-translational modifications for N4BP2L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for N4BP2L2 Gene

Domains & Families for N4BP2L2 Gene

Protein Domains for N4BP2L2 Gene

Suggested Antigen Peptide Sequences for N4BP2L2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with N4BP2L2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for N4BP2L2 Gene

Function for N4BP2L2 Gene

Gene Ontology (GO) - Molecular Function for N4BP2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity ISS --
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 19506020
GO:0019899 enzyme binding IPI 19506020
genes like me logo Genes that share ontologies with N4BP2L2: view
genes like me logo Genes that share phenotypes with N4BP2L2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for N4BP2L2 Gene

Localization for N4BP2L2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for N4BP2L2 gene
Compartment Confidence
extracellular 5
nucleus 5
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for N4BP2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19506020
GO:0017053 transcriptional repressor complex IDA 19506020
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with N4BP2L2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for N4BP2L2 Gene

Pathways & Interactions for N4BP2L2 Gene

SuperPathways for N4BP2L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for N4BP2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:1902035 positive regulation of hematopoietic stem cell proliferation IMP 19506020
GO:1902037 negative regulation of hematopoietic stem cell differentiation IMP 19506020
genes like me logo Genes that share ontologies with N4BP2L2: view

No data available for Pathways by source and SIGNOR curated interactions for N4BP2L2 Gene

Drugs & Compounds for N4BP2L2 Gene

No Compound Related Data Available

Transcripts for N4BP2L2 Gene

Unigene Clusters for N4BP2L2 Gene

NEDD4 binding protein 2-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for N4BP2L2 Gene

No ASD Table

Relevant External Links for N4BP2L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for N4BP2L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for N4BP2L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for N4BP2L2 Gene

This gene is overexpressed in Plasma (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for N4BP2L2 Gene

Protein tissue co-expression partners for N4BP2L2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of N4BP2L2 Gene:


SOURCE GeneReport for Unigene cluster for N4BP2L2 Gene:


Evidence on tissue expression from TISSUES for N4BP2L2 Gene

  • Liver(4.6)
  • Intestine(4.4)
  • Nervous system(3.9)
  • Lung(3.7)
  • Stomach(2)
genes like me logo Genes that share expression patterns with N4BP2L2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for N4BP2L2 Gene

Orthologs for N4BP2L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for N4BP2L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia N4BP2L2 34 35
  • 99.31 (n)
(Canis familiaris)
Mammalia N4BP2L2 34
  • 86.94 (n)
(Bos Taurus)
Mammalia N4BP2L2 34
  • 86.51 (n)
(Mus musculus)
Mammalia N4bp2l2 34 16
  • 80.06 (n)
(Rattus norvegicus)
Mammalia N4bp2l2 34
  • 78.75 (n)
(Monodelphis domestica)
Mammalia N4BP2L2 35
  • 27 (a)
(Gallus gallus)
Aves N4BP2L2 34
  • 61.22 (n)
(Anolis carolinensis)
Reptilia N4BP2L2 35
  • 68 (a)
Species where no ortholog for N4BP2L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for N4BP2L2 Gene

Gene Tree for N4BP2L2 (if available)
Gene Tree for N4BP2L2 (if available)

Paralogs for N4BP2L2 Gene

Paralogs for N4BP2L2 Gene

(3) SIMAP similar genes for N4BP2L2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with N4BP2L2: view

Variants for N4BP2L2 Gene

Sequence variations from dbSNP and Humsavar for N4BP2L2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000012513 -- 32,533,947(+) TTGAA(G/T)TCAGG intron-variant
rs1000023203 -- 32,491,377(+) AAGGG(A/G)AAATA intron-variant, upstream-variant-2KB
rs1000033775 -- 32,474,407(+) CTTAG(C/T)GGCCT intron-variant
rs1000034790 -- 32,435,190(+) TTTAC(-/T)GCTAT intron-variant
rs1000053451 -- 32,484,312(+) ACAGA(C/G)AAAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for N4BP2L2 Gene

Variant ID Type Subtype PubMed ID
esv2747243 CNV deletion 23290073
nsv1126340 CNV deletion 24896259
nsv832576 CNV gain 17160897

Variation tolerance for N4BP2L2 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.70; 73.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for N4BP2L2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for N4BP2L2 Gene

Disorders for N4BP2L2 Gene

Relevant External Links for N4BP2L2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for N4BP2L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for N4BP2L2 Gene

Publications for N4BP2L2 Gene

  1. Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. (PMID: 8812419) Couch F.J. … Simard J. (Genomics 1996) 2 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for N4BP2L2 Gene

Sources for N4BP2L2 Gene

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