Free for academic non-profit institutions. Other users need a Commercial license

Aliases for N4BP2L2 Gene

Aliases for N4BP2L2 Gene

  • NEDD4 Binding Protein 2 Like 2 2 3 5
  • Phosphonoformate Immuno-Associated Protein 5 2 3 4
  • PFAAP5 3 4
  • CG005 3 4
  • NEDD4-Binding Protein 2-Like 2 3
  • Protein From BRCA2 Region 3
  • 92M18.3 3
  • CG016 3

External Ids for N4BP2L2 Gene

Previous GeneCards Identifiers for N4BP2L2 Gene

  • GC13M031891
  • GC13M033007
  • GC13M013818

Summaries for N4BP2L2 Gene

GeneCards Summary for N4BP2L2 Gene

N4BP2L2 (NEDD4 Binding Protein 2 Like 2) is a Protein Coding gene. GO annotations related to this gene include enzyme binding and RNA polymerase II transcription corepressor activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for N4BP2L2 Gene

Genomics for N4BP2L2 Gene

Regulatory Elements for N4BP2L2 Gene

Enhancers for N4BP2L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F033270 1.1 FANTOM5 Ensembl ENCODE 31.7 -739.7 -739696 16.6 PKNOX1 ZNF133 ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF2 YY1 SLC30A9 N4BP2L2 STARD13-AS RFC3 KL STARD13 LOC105370154
GH13F032537 0.6 ENCODE 21.6 +0.4 384 2.4 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 N4BP2L2 GC13M032536
GH13F032600 0.8 Ensembl 13.5 -61.9 -61916 0.8 FOXP2 ZNF264 N4BP2L2 ENSG00000212293 PDS5B GC13M032668
GH13F033243 0.2 ENCODE 11.5 -706.1 -706110 2.8 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 ZNF143 STARD13 N4BP2L2 STARD13-AS KL LOC105370154
GH13F032471 1 Ensembl ENCODE 11.2 +66.9 66922 1.8 PKNOX1 TAL1 UBTF ZFHX2 ZNF316 GATA2 NCOR1 NFE2 TRIM24 MAFK N4BP2L2 N4BP2L1 ENSG00000212293 PDS5B ATP8A2P2 ENSG00000270008
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around N4BP2L2 on UCSC Golden Path with GeneCards custom track

Promoters for N4BP2L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000514004 485 2800 HDGF PKNOX1 ARNT CREB3L1 SIN3A ARID4B DMAP1 YY1 ZNF207 ZNF143

Genomic Location for N4BP2L2 Gene

Chromosome:
13
Start:
32,432,417 bp from pter
End:
32,538,885 bp from pter
Size:
106,469 bases
Orientation:
Minus strand

Genomic View for N4BP2L2 Gene

Genes around N4BP2L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
N4BP2L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for N4BP2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for N4BP2L2 Gene

Proteins for N4BP2L2 Gene

  • Protein details for N4BP2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92802-N42L2_HUMAN
    Recommended name:
    NEDD4-binding protein 2-like 2
    Protein Accession:
    Q92802
    Secondary Accessions:
    • A3KME8

    Protein attributes for N4BP2L2 Gene

    Size:
    583 amino acids
    Molecular mass:
    67459 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI31632.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BP361938; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for N4BP2L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for N4BP2L2 Gene

Post-translational modifications for N4BP2L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for N4BP2L2 Gene

Domains & Families for N4BP2L2 Gene

Protein Domains for N4BP2L2 Gene

Suggested Antigen Peptide Sequences for N4BP2L2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with N4BP2L2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for N4BP2L2 Gene

Function for N4BP2L2 Gene

Gene Ontology (GO) - Molecular Function for N4BP2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity ISS --
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 19506020
GO:0019899 enzyme binding IPI 19506020
genes like me logo Genes that share ontologies with N4BP2L2: view
genes like me logo Genes that share phenotypes with N4BP2L2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for N4BP2L2 Gene

Localization for N4BP2L2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for N4BP2L2 Gene COMPARTMENTS Subcellular localization image for N4BP2L2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for N4BP2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19506020
GO:0017053 transcriptional repressor complex IDA 19506020
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with N4BP2L2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for N4BP2L2 Gene

Pathways & Interactions for N4BP2L2 Gene

SuperPathways for N4BP2L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for N4BP2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:1902035 positive regulation of hematopoietic stem cell proliferation IMP 19506020
GO:1902037 negative regulation of hematopoietic stem cell differentiation IMP 19506020
genes like me logo Genes that share ontologies with N4BP2L2: view

No data available for Pathways by source and SIGNOR curated interactions for N4BP2L2 Gene

Transcripts for N4BP2L2 Gene

Unigene Clusters for N4BP2L2 Gene

NEDD4 binding protein 2-like 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for N4BP2L2 Gene

No ASD Table

Relevant External Links for N4BP2L2 Gene

GeneLoc Exon Structure for
N4BP2L2
ECgene alternative splicing isoforms for
N4BP2L2

Expression for N4BP2L2 Gene

mRNA expression in normal human tissues for N4BP2L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for N4BP2L2 Gene

This gene is overexpressed in Plasma (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for N4BP2L2 Gene



Protein tissue co-expression partners for N4BP2L2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of N4BP2L2 Gene:

N4BP2L2

SOURCE GeneReport for Unigene cluster for N4BP2L2 Gene:

Hs.507680
genes like me logo Genes that share expression patterns with N4BP2L2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for N4BP2L2 Gene

Orthologs for N4BP2L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for N4BP2L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia N4BP2L2 34 35
  • 99.31 (n)
dog
(Canis familiaris)
Mammalia N4BP2L2 34
  • 86.94 (n)
cow
(Bos Taurus)
Mammalia N4BP2L2 34
  • 86.51 (n)
mouse
(Mus musculus)
Mammalia N4bp2l2 34 16
  • 80.06 (n)
rat
(Rattus norvegicus)
Mammalia N4bp2l2 34
  • 78.75 (n)
oppossum
(Monodelphis domestica)
Mammalia N4BP2L2 35
  • 27 (a)
OneToOne
chicken
(Gallus gallus)
Aves N4BP2L2 34
  • 61.22 (n)
lizard
(Anolis carolinensis)
Reptilia N4BP2L2 35
  • 68 (a)
OneToOne
Species where no ortholog for N4BP2L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for N4BP2L2 Gene

ENSEMBL:
Gene Tree for N4BP2L2 (if available)
TreeFam:
Gene Tree for N4BP2L2 (if available)

Paralogs for N4BP2L2 Gene

(3) SIMAP similar genes for N4BP2L2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with N4BP2L2: view

No data available for Paralogs for N4BP2L2 Gene

Variants for N4BP2L2 Gene

Sequence variations from dbSNP and Humsavar for N4BP2L2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1029303 -- 32,439,013(+) GCTTC(A/G)TAGCC intron-variant
rs1045925 -- 32,517,172(-) AGTTA(C/T)CATCC intron-variant, utr-variant-3-prime
rs10492398 -- 32,506,763(+) AGGGC(C/T)GGAAT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10572532 -- 32,450,871(+) CCCCT(-/TC)TCTCT intron-variant
rs1064788 -- 32,497,532(-) TGATG(C/G)CCAGA intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for N4BP2L2 Gene

Variant ID Type Subtype PubMed ID
esv2747243 CNV deletion 23290073
nsv1126340 CNV deletion 24896259
nsv832576 CNV gain 17160897

Variation tolerance for N4BP2L2 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.70; 73.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for N4BP2L2 Gene

Human Gene Mutation Database (HGMD)
N4BP2L2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
N4BP2L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for N4BP2L2 Gene

Disorders for N4BP2L2 Gene

Relevant External Links for N4BP2L2

Genetic Association Database (GAD)
N4BP2L2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
N4BP2L2

No disorders were found for N4BP2L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for N4BP2L2 Gene

Publications for N4BP2L2 Gene

  1. Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. (PMID: 8812419) Couch F.J. … Simard J. (Genomics 1996) 2 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for N4BP2L2 Gene

Sources for N4BP2L2 Gene

Content
Loading form....