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Aliases for N4BP2L2 Gene

Aliases for N4BP2L2 Gene

  • NEDD4 Binding Protein 2-Like 2 2 3 5
  • Phosphonoformate Immuno-Associated Protein 5 2 3 4
  • PFAAP5 3 4
  • CG005 3 4
  • Protein From BRCA2 Region 3
  • 92M18.3 3
  • CG016 3

External Ids for N4BP2L2 Gene

Previous GeneCards Identifiers for N4BP2L2 Gene

  • GC13M031891
  • GC13M033007
  • GC13M013818

Summaries for N4BP2L2 Gene

GeneCards Summary for N4BP2L2 Gene

N4BP2L2 (NEDD4 Binding Protein 2-Like 2) is a Protein Coding gene. GO annotations related to this gene include enzyme binding and RNA polymerase II transcription corepressor activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for N4BP2L2 Gene

Genomics for N4BP2L2 Gene

Regulatory Elements for N4BP2L2 Gene

Enhancers for N4BP2L2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around N4BP2L2 on UCSC Golden Path with GeneCards custom track

Promoters for N4BP2L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around N4BP2L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for N4BP2L2 Gene

32,432,417 bp from pter
32,538,885 bp from pter
106,469 bases
Minus strand

Genomic View for N4BP2L2 Gene

Genes around N4BP2L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
N4BP2L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for N4BP2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for N4BP2L2 Gene

Proteins for N4BP2L2 Gene

  • Protein details for N4BP2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NEDD4-binding protein 2-like 2
    Protein Accession:
    Secondary Accessions:
    • A3KME8

    Protein attributes for N4BP2L2 Gene

    583 amino acids
    Molecular mass:
    67459 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI31632.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BP361938; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for N4BP2L2 Gene


neXtProt entry for N4BP2L2 Gene

Proteomics data for N4BP2L2 Gene at MOPED

Post-translational modifications for N4BP2L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for N4BP2L2 Gene

Domains & Families for N4BP2L2 Gene

Protein Domains for N4BP2L2 Gene

Suggested Antigen Peptide Sequences for N4BP2L2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with N4BP2L2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for N4BP2L2 Gene

Function for N4BP2L2 Gene

genes like me logo Genes that share phenotypes with N4BP2L2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for N4BP2L2 Gene

Localization for N4BP2L2 Gene

Subcellular locations from

Jensen Localization Image for N4BP2L2 Gene COMPARTMENTS Subcellular localization image for N4BP2L2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for N4BP2L2 Gene

Pathways & Interactions for N4BP2L2 Gene

SuperPathways for N4BP2L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for N4BP2L2 Gene


No data available for Pathways by source and SIGNOR curated interactions for N4BP2L2 Gene

Drugs & Compounds for N4BP2L2 Gene

No Compound Related Data Available

Transcripts for N4BP2L2 Gene

Unigene Clusters for N4BP2L2 Gene

NEDD4 binding protein 2-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for N4BP2L2 Gene

No ASD Table

Relevant External Links for N4BP2L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for N4BP2L2 Gene

mRNA expression in normal human tissues for N4BP2L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for N4BP2L2 Gene

This gene is overexpressed in Plasma (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for N4BP2L2 Gene

SOURCE GeneReport for Unigene cluster for N4BP2L2 Gene Hs.507680

genes like me logo Genes that share expression patterns with N4BP2L2: view

Protein tissue co-expression partners for N4BP2L2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for N4BP2L2 Gene

Orthologs for N4BP2L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for N4BP2L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia N4BP2L2 35
  • 86.51 (n)
  • 76.3 (a)
(Canis familiaris)
Mammalia N4BP2L2 35
  • 86.94 (n)
  • 75.85 (a)
(Mus musculus)
Mammalia N4bp2l2 35
  • 80.06 (n)
  • 66.09 (a)
N4bp2l2 16
(Pan troglodytes)
Mammalia N4BP2L2 35
  • 99.31 (n)
  • 98.46 (a)
N4BP2L2 36
  • 97 (a)
(Rattus norvegicus)
Mammalia N4bp2l2 35
  • 78.75 (n)
  • 67.42 (a)
(Monodelphis domestica)
Mammalia N4BP2L2 36
  • 27 (a)
(Gallus gallus)
Aves N4BP2L2 35
  • 61.22 (n)
  • 46.22 (a)
(Anolis carolinensis)
Reptilia N4BP2L2 36
  • 68 (a)
Species with no ortholog for N4BP2L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for N4BP2L2 Gene

Gene Tree for N4BP2L2 (if available)
Gene Tree for N4BP2L2 (if available)

Paralogs for N4BP2L2 Gene

(3) SIMAP similar genes for N4BP2L2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with N4BP2L2: view

No data available for Paralogs for N4BP2L2 Gene

Variants for N4BP2L2 Gene

Sequence variations from dbSNP and Humsavar for N4BP2L2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs34062461 - 32,536,214(+) AGGAT(A/G)TACTG intron-variant, upstream-variant-2KB, reference, missense
rs9337 -- 32,517,104(+) TATTA(C/G)AATCA intron-variant, utr-variant-3-prime
rs14166 -- 32,526,994(+) TTAAT(A/T)TTCAC intron-variant
rs45604 -- 32,525,210(+) CATTT(G/T)CAGAA intron-variant
rs169600 -- 32,481,483(-) TGGTA(A/G)TCAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for N4BP2L2 Gene

Variant ID Type Subtype PubMed ID
nsv832576 CNV Gain 17160897
esv2747243 CNV Deletion 23290073
nsv899969 CNV Gain 21882294

Variation tolerance for N4BP2L2 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.70; 73.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for N4BP2L2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for N4BP2L2 Gene

Disorders for N4BP2L2 Gene

Relevant External Links for N4BP2L2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for N4BP2L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for N4BP2L2 Gene

Publications for N4BP2L2 Gene

  1. Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. (PMID: 8812419) Couch F.J. … Simard J. (Genomics 1996) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PMID: 23535729) Michailidou K. … Easton D.F. (Nat. Genet. 2013) 3

Products for N4BP2L2 Gene

Sources for N4BP2L2 Gene