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Aliases for N4BP2L2 Gene

Aliases for N4BP2L2 Gene

  • NEDD4 Binding Protein 2-Like 2 2 3
  • Phosphonoformate Immuno-Associated Protein 5 2 3 4
  • PFAAP5 3 4
  • CG005 3 4
  • NEDD4-Binding Protein 2-Like 2 3
  • Protein From BCRA2 Region 3
  • 92M18.3 (Novel Protein) 3
  • 92M18.3 3
  • CG016 3

External Ids for N4BP2L2 Gene

Summaries for N4BP2L2 Gene

GeneCards Summary for N4BP2L2 Gene

N4BP2L2 (NEDD4 Binding Protein 2-Like 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for N4BP2L2 Gene

Genomics for N4BP2L2 Gene

Genomic Location for N4BP2L2 Gene

Start:
32,432,417 bp from pter
End:
32,542,702 bp from pter
Size:
110,286 bases
Orientation:
Minus strand

Genomic View for N4BP2L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for N4BP2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for N4BP2L2 Gene

Regulatory Elements for N4BP2L2 Gene

Proteins for N4BP2L2 Gene

  • Protein details for N4BP2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92802-N42L2_HUMAN
    Recommended name:
    NEDD4-binding protein 2-like 2
    Protein Accession:
    Q92802
    Secondary Accessions:
    • A3KME8

    Protein attributes for N4BP2L2 Gene

    Size:
    583 amino acids
    Molecular mass:
    67459 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI31632.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BP361938; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for N4BP2L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for N4BP2L2 Gene

Proteomics data for N4BP2L2 Gene at MOPED

Post-translational modifications for N4BP2L2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys9

Other Protein References for N4BP2L2 Gene

No data available for DME Specific Peptides for N4BP2L2 Gene

Domains for N4BP2L2 Gene

Protein Domains for N4BP2L2 Gene

Suggested Antigen Peptide Sequences for N4BP2L2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with N4BP2L2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for N4BP2L2 Gene

Function for N4BP2L2 Gene

Gene Ontology (GO) - Molecular Function for N4BP2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity ISS --
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 19506020
GO:0005524 ATP binding --
GO:0016301 kinase activity --
genes like me logo Genes that share ontologies with N4BP2L2: view

Phenotypes for N4BP2L2 Gene

GenomeRNAi human phenotypes for N4BP2L2:
genes like me logo Genes that share phenotypes with N4BP2L2: view

miRNA for N4BP2L2 Gene

miRTarBase miRNAs that target N4BP2L2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for N4BP2L2 Gene

Localization for N4BP2L2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for N4BP2L2 Gene COMPARTMENTS Subcellular localization image for N4BP2L2 gene
Compartment Confidence
endoplasmic reticulum 2
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for N4BP2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19506020
GO:0005737 cytoplasm --
GO:0017053 transcriptional repressor complex IDA 19506020
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with N4BP2L2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for N4BP2L2 Gene

Pathways for N4BP2L2 Gene

SuperPathways for N4BP2L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for N4BP2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:1902035 positive regulation of hematopoietic stem cell proliferation IMP 19506020
GO:1902037 negative regulation of hematopoietic stem cell differentiation IMP 19506020
genes like me logo Genes that share ontologies with N4BP2L2: view

No data available for Pathways by source for N4BP2L2 Gene

Transcripts for N4BP2L2 Gene

Unigene Clusters for N4BP2L2 Gene

NEDD4 binding protein 2-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for N4BP2L2 Gene

No ASD Table

Relevant External Links for N4BP2L2 Gene

GeneLoc Exon Structure for
N4BP2L2
ECgene alternative splicing isoforms for
N4BP2L2

Expression for N4BP2L2 Gene

mRNA expression in normal human tissues for N4BP2L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for N4BP2L2 Gene

SOURCE GeneReport for Unigene cluster for N4BP2L2 Gene Hs.507680

genes like me logo Genes that share expressions with N4BP2L2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for N4BP2L2 Gene

Orthologs for N4BP2L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for N4BP2L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia N4BP2L2 35
  • 99.31 (n)
  • 98.46 (a)
N4BP2L2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia N4BP2L2 35
  • 86.51 (n)
  • 76.3 (a)
dog
(Canis familiaris)
Mammalia N4BP2L2 35
  • 86.94 (n)
  • 75.85 (a)
mouse
(Mus musculus)
Mammalia N4bp2l2 35
  • 80.06 (n)
  • 66.09 (a)
N4bp2l2 16
oppossum
(Monodelphis domestica)
Mammalia N4BP2L2 36
  • 27 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia N4bp2l2 35
  • 78.75 (n)
  • 67.42 (a)
chicken
(Gallus gallus)
Aves N4BP2L2 35
  • 61.22 (n)
  • 46.22 (a)
lizard
(Anolis carolinensis)
Reptilia N4BP2L2 36
  • 68 (a)
OneToOne
Species with no ortholog for N4BP2L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for N4BP2L2 Gene

ENSEMBL:
Gene Tree for N4BP2L2 (if available)
TreeFam:
Gene Tree for N4BP2L2 (if available)

Paralogs for N4BP2L2 Gene

Selected SIMAP similar genes for N4BP2L2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with N4BP2L2: view

No data available for Paralogs for N4BP2L2 Gene

Variants for N4BP2L2 Gene

Sequence variations from dbSNP and Humsavar for N4BP2L2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs9337 -- 32,517,104(+) TATTA(C/G)AATCA intron-variant, utr-variant-3-prime
rs14166 -- 32,526,994(+) TTAAT(A/T)TTCAC intron-variant
rs45604 -- 32,525,210(+) CATTT(G/T)CAGAA intron-variant
rs169600 -- 32,481,483(-) TGGTA(A/G)TCAGC intron-variant
rs207620 -- 32,539,266(+) TACTG(C/G)GGCGC upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for N4BP2L2 Gene

Variant ID Type Subtype PubMed ID
nsv832576 CNV Gain 17160897
esv2747243 CNV Deletion 23290073
nsv899969 CNV Gain 21882294

Relevant External Links for N4BP2L2 Gene

HapMap Linkage Disequilibrium report
N4BP2L2
Human Gene Mutation Database (HGMD)
N4BP2L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for N4BP2L2 Gene

Disorders for N4BP2L2 Gene

Relevant External Links for N4BP2L2

Genetic Association Database (GAD)
N4BP2L2
genes like me logo Genes that share disorders with N4BP2L2: view

No data available for UniProtKB/Swiss-Prot for N4BP2L2 Gene

Publications for N4BP2L2 Gene

  1. Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. (PMID: 8812419) Couch F.J. … Simard J. (Genomics 1996) 2 3 4
  2. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  3. A pancreatic cancer-specific expression profile. (PMID: 8895530) Gress T.M. … Lehrach H. (Oncogene 1996) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for N4BP2L2 Gene

  • antibodies-online proteins for N4BP2L2
  • antibodies-online antibodies for N4BP2L2
  • antibodies-online kits for N4BP2L2

Sources for N4BP2L2 Gene

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