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N4BP2L1 Gene

protein-coding GIFtS: 37

GC13M031872

NEDD4 binding protein 2-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CG018 ^¹, ²
CG081 ^³
OTTHUMP00000018226 ^²
OTTHUMP00000018227 ^²
OTTHUMP00000018228 ^²

Descriptions
NEDD4 binding protein 2-like 1 ^²

External Ids
HGNC: 25037¹
Entrez Gene: 90634²
UniProtKB: Q5TBK1³
Ensembl: ENSG00000139597⁷

Search outside databases for aliases for N4BP2L1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12-q13 Ensembl cytogenetic band: 13q13.1 HGNC cytogenetic band: 13q13.1

N4BP2L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M031872: (about GC identifiers)

Start:	31,872,860 bp from pter
End:	31,900,315 bp from pter
Size:	27,456 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000013.9 NT_024524.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: N42L1_HUMAN, Q5TBK1 (See protein sequence)

Recommended Name: NEDD4-binding protein 2-like 1

Size: 243 amino acids; 28981 Da

Secondary accessions: A4QN21 Q5TBK0

Alternative splicing: 2 isoforms: Q5TBK1-1 Q5TBK1-2

REFSEQ proteins (2 alternative transcripts):

NP_001073159.1 NP_438169.2

ENSEMBL proteins:

ENSP00000369476 ENSP00000345838 ENSP00000369472 ENSP00000369484 ENSP00000369473

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (CG018)

OriGene Purified Recombinant Human Protein: N4BP2L1

Antibodies for N4BP2L1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for N4BP2L1

Assays for N4BP2L1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q5TBK1

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (N4BP2L1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_052818

Applied Biosystems Silencer® siRNAs for N4BP2L1

Sigma-Aldrich siRNA for N4BP2L1

Sigma-Aldrich shRNA for N4BP2L1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for N4BP2L1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001079691
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001079691
untagged cDNA clones in CMV expression vector (see all 4): AL049787

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_052818

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for N4BP2L1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (N4BP2L1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_052818

Sigma-Aldrich siRNA for N4BP2L1

Sigma-Aldrich shRNA for N4BP2L1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001079691 NM_052818

REFSEQ mRNAs for N4BP2L1 gene (2 alternative transcripts):

NM_001079691.1 NM_052818.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001079691 NM_052818

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001079691
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001079691
                                 untagged cDNA clones in CMV expression vector (see all 4): AL049787

Additional cDNA sequence:

AF113009.1 AL049785.1 AL049786.1 AL049787.1 AL049788.1 AL832677.1 BC011650.2 BC022188.2

BC068049.1 BC125050.1 BX648509.1 U50527.1 U50528.1 U57962.1

21 DOTS entries:

DT.97796380 DT.95123406 DT.114407 DT.92017106 DT.121643809 DT.114408 DT.99985284 DT.100742701

DT.95123394 DT.121643808 DT.70102467 DT.92425277 DT.120793869 DT.40109676 DT.40256654 DT.412749

DT.86852729 DT.120793895 DT.95085043 DT.97770634 DT.120793922

24/449 AceView cDNA sequences (see all 449 ):

AI684351 AI434835 AI826657 AW009076 AL049787 BM670744 AA488718 BQ012091

BU674950 AU117279 BE017964 BQ012147 AL049802 AI581114 AI241456 CA307221

AI299025 BX484756 BU160899 AI536840 CR601845 AA737478 CA443002 BM479613

Unigene Cluster for N4BP2L1:

NEDD4 binding protein 2-like 1

Hs.161220 [show with all ESTs]

Unigene Representative Sequence: AL832677

GeneLoc Exon Structure

5 Ensembl transcripts including schematic representations:

ENST00000380133 ENST00000343281 ENST00000380129 ENST00000380139 ENST00000380130

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

N4BP2L1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for N4BP2L1

¹ / ²

15 probe-sets matching N4BP2L1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
80870_at²	U95-D	1	1.00	1.00	0.70	1.11	--	--	--	--	--
34239_at²	U95-A	1	1.00	1.00	0.96	0.87	--	--	--	--	--
1527_s_at²	U95-A	1	1.00	1.00	0.94	1.11	--	--	--	--	--
34240_s_at²	U95-A	1	1.00	1.00	0.85	0.94	--	--	--	--	--
51550_at*²	U95-B	1	1.00	1.00	0.72	0.98	--	--	--	--	--
213375_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
217197_x_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
243843_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
214906_x_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
229718_at*²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
213375_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217197_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
243843_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214906_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229718_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks N4BP2L1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: ATAGACAAGA

SOURCE GeneReport for Unigene cluster: Hs.161220

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for N4BP2L1 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	N4BP2L1¹	--	NEDD4 binding protein 2-like 1	98.7(n) 98.33(a)	741313 XM_001143836.1 XP_001143836.1
rat (Rattus norvegicus)	N4bp2l1¹	--	NEDD4 binding protein 2-like 1	85.65(n) 85.65(a)	498131 XM_001070954.1 XP_001070954.1
mouse (Mus musculus)	N4bp2l1^{1, 5}	5⁵	NEDD4 binding protein 2-like 1^{1, 5}	86.08(n)¹ 85.65(a)¹	100637¹ NM_133898.3¹ NP_598659.2¹ AA915465⁵ AI428195⁵ (see all 11)
chicken (Gallus gallus)	N4BP2L1¹	--	NEDD4 binding protein 2-like 1	74.03(n) 71.82(a)	418914 XM_417110.2 XP_417110.1

About this table Species with no ortholog for N4BP2L1

ENSEMBL Gene Tree for N4BP2L1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for N4BP2L1 gene

N4BP2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/217 NCBI SNPs in N4BP2L1 are shown (see all 217 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 87)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs9590958^1,2	A,C,F,H	31874695(+)	`TACCGA/GTGGAG`	2	--	ut3¹ ese³		7		EU EA WA NA	562
	rs17692629^1,2	C,F,H	31874608(+)	`TTTTTA/GGATAC`	2	--	ut3¹		8		NA EA EU WA	624
	rs10492397^1,2	C,F,H	31874358(+)	`TTCAGG/ATTTAA`	2	--	ut3¹ ese³		12		NS NA EU EA WA	656
	rs2761363^1,2	F,H	31873916(+)	`CCATTA/GTATAA`	2	--	ut3¹ ese³		4		EU EA WA	420
	rs3803282^1,2	F,H	31872904(+)	`AATGAG/AACCCT`	2	--	ut3¹		4		EU EA WA	420
--	rs206339^1,2	A	31901728(+)	`gcaaaC/Tacgct`	2	--	ng3¹		0	--	--	--	--
	rs3752446^1,2	F	31874022(+)	`TCACAT/ATAAAT`	2	--	ut3¹		1		EA	1474
	rs206346^1,2	H	31872370(+)	`AAATAC/TGTTTA`	2	--	ng5¹		4		EU EA WA	414
	rs7982943^1,2	H	31873985(+)	`AGAGCA/GTACGT`	2	--	ut3¹		4		EU EA WA	420
	rs206327^1,2	A,C,F,H,O	31892393(+)	`CCTTTA/CAGTAT`	2	--	int¹		12		EU EA WA NA	1052

About this table

HapMap Linkage Disequilibrium images for N4BP2L1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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4 PubMed articles for N4BP2L1 gene:

Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. (PubMed id 8812419)^{2, 3} Couch F.J....Simard J. (1996)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)⁴ Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 90634	HGNC: 25037	AceView: PFAAP5	Ensembl:ENSG00000139597	euGenes: HUgn90634
ECgene: N4BP2L1	H-InvDB: N4BP2L1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for N4BP2L1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for N4BP2L1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for N4BP2L1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for N4BP2L1		Browse antibodies at Sigma-Aldrich
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N4BP2L1 Gene

protein-coding GIFtS: 37

Aliases &
Descriptions
for N4BP2L1

Summaries
for N4BP2L1

Genomic Location
for N4BP2L1

Proteins
for N4BP2L1

Protein Domains/
Families
for N4BP2L1

Gene Function
for N4BP2L1

Pathways & Interactions
for N4BP2L1

Drugs & Compounds
for N4BP2L1

Transcripts
for N4BP2L1

Expression
for N4BP2L1

Orthologs
for N4BP2L1

Paralogs
for N4BP2L1

SNPs/Variants
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Disorders & Mutations
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Medical News
for N4BP2L1

Publications
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Genome Databases showing N4BP2L1

Other Databases showing N4BP2L1

Specialized Databases showing N4BP2L1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

N4BP2L1 Gene

protein-coding GIFtS: 37

Aliases & Descriptionsfor N4BP2L1

Summariesfor N4BP2L1

Genomic Locationfor N4BP2L1

Proteinsfor N4BP2L1

Protein Domains/Familiesfor N4BP2L1

Gene Functionfor N4BP2L1

Pathways & Interactionsfor N4BP2L1

Drugs & Compoundsfor N4BP2L1

Transcriptsfor N4BP2L1

Expression for N4BP2L1

Orthologsfor N4BP2L1

Paralogsfor N4BP2L1

SNPs/Variantsfor N4BP2L1

Disorders & Mutationsfor N4BP2L1

Medical Newsfor N4BP2L1

Publicationsfor N4BP2L1

Search for N4BP2L1

Genome Databases showing N4BP2L1

Other Databases showing N4BP2L1

Specialized Databases showing N4BP2L1

Licensable Technologiesfor N4BP2L1

Servicesfor N4BP2L1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for N4BP2L1

Summaries
for N4BP2L1

Genomic Location
for N4BP2L1

Proteins
for N4BP2L1

Protein Domains/
Families
for N4BP2L1

Gene Function
for N4BP2L1

Pathways & Interactions
for N4BP2L1

Drugs & Compounds
for N4BP2L1

Transcripts
for N4BP2L1

Expression
for N4BP2L1

Orthologs
for N4BP2L1

Paralogs
for N4BP2L1

SNPs/Variants
for N4BP2L1

Disorders & Mutations
for N4BP2L1

Medical News
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Publications
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Licensable Technologies
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