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Aliases for N4BP2L1 Gene

Aliases for N4BP2L1 Gene

  • NEDD4 Binding Protein 2 Like 1 2 3 5
  • Hypothetical Gene CG018 2 3
  • NEDD4-Binding Protein 2-Like 1 3
  • CG018 3
  • CG081 4

External Ids for N4BP2L1 Gene

Previous GeneCards Identifiers for N4BP2L1 Gene

  • GC13M031872
  • GC13M032974
  • GC13M013786
  • GC13M032410

Summaries for N4BP2L1 Gene

GeneCards Summary for N4BP2L1 Gene

N4BP2L1 (NEDD4 Binding Protein 2 Like 1) is a Protein Coding gene. GO annotations related to this gene include kinase activity. An important paralog of this gene is N4BP2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for N4BP2L1 Gene

Genomics for N4BP2L1 Gene

Regulatory Elements for N4BP2L1 Gene

Enhancers for N4BP2L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G032471 1.1 Ensembl ENCODE 11.2 -42.4 -42350 1.8 PKNOX1 PTBP1 TCF12 GATA2 EGR1 EGR2 CREB3 NFIC SMARCA4 KLF16 N4BP2L2 N4BP2L1 ENSG00000212293 PDS5B ATP8A2P2 ENSG00000270008
GH13G032252 1.2 Ensembl ENCODE 9.4 +175.0 174957 3.7 PKNOX1 FOXA2 ATF1 MLX ARID4B ZNF48 YY1 SLC30A9 FOS PAF1 FRY FRY-AS1 N4BP2L1 GC13P032297 GC13P032060
GH13G032454 0.8 ENCODE 11.8 -25.7 -25732 0.9 SOX13 DRAP1 TFAP4 ZNF792 SAP130 MLX ZFP64 ZMYM3 ARID4B DMAP1 ATP8A2P2 N4BP2L1 N4BP2L2 PDS5B ENSG00000270008
GH13G032264 0.8 ENCODE 9.2 +164.2 164219 1.9 ELF3 SOX13 FOXA2 NFIB JUN ASH2L ZNF48 RAD21 GATA2 ETV6 N4BP2L1 GC13P032297 GC13P032060
GH13G031960 0.8 dbSUPER 9.1 +467.2 467225 3.9 DMAP1 ZBTB40 YY1 GLIS2 GATA4 ETV6 THAP11 PAF1 POLR2H ZNF589 N4BP2L1 ENSG00000279314 ENSG00000278732
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around N4BP2L1 on UCSC Golden Path with GeneCards custom track

Promoters for N4BP2L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000060900 1914 2201 HDGF HNRNPUL1 PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Location for N4BP2L1 Gene

Chromosome:
13
Start:
32,400,723 bp from pter
End:
32,429,614 bp from pter
Size:
28,892 bases
Orientation:
Minus strand

Genomic View for N4BP2L1 Gene

Genes around N4BP2L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
N4BP2L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for N4BP2L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for N4BP2L1 Gene

Proteins for N4BP2L1 Gene

  • Protein details for N4BP2L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TBK1-N42L1_HUMAN
    Recommended name:
    NEDD4-binding protein 2-like 1
    Protein Accession:
    Q5TBK1
    Secondary Accessions:
    • A4QN21
    • Q5TBK0

    Protein attributes for N4BP2L1 Gene

    Size:
    243 amino acids
    Molecular mass:
    28981 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for N4BP2L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for N4BP2L1 Gene

Post-translational modifications for N4BP2L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for N4BP2L1 Gene

Domains & Families for N4BP2L1 Gene

Protein Domains for N4BP2L1 Gene

Suggested Antigen Peptide Sequences for N4BP2L1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with N4BP2L1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for N4BP2L1 Gene

Function for N4BP2L1 Gene

Phenotypes for N4BP2L1 Gene

genes like me logo Genes that share phenotypes with N4BP2L1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for N4BP2L1 Gene

Localization for N4BP2L1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for N4BP2L1 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for N4BP2L1 Gene

Pathways & Interactions for N4BP2L1 Gene

SuperPathways for N4BP2L1 Gene

No Data Available

Interacting Proteins for N4BP2L1 Gene

Gene Ontology (GO) - Biological Process for N4BP2L1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for N4BP2L1 Gene

Drugs & Compounds for N4BP2L1 Gene

No Compound Related Data Available

Transcripts for N4BP2L1 Gene

Unigene Clusters for N4BP2L1 Gene

NEDD4 binding protein 2-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for N4BP2L1 Gene

No ASD Table

Relevant External Links for N4BP2L1 Gene

GeneLoc Exon Structure for
N4BP2L1
ECgene alternative splicing isoforms for
N4BP2L1

Expression for N4BP2L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for N4BP2L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for N4BP2L1 Gene

This gene is overexpressed in Liver (24.7), CD8 Tcells (20.4), Blymphocyte (15.6), and NK cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for N4BP2L1 Gene



Protein tissue co-expression partners for N4BP2L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of N4BP2L1 Gene:

N4BP2L1

SOURCE GeneReport for Unigene cluster for N4BP2L1 Gene:

Hs.732118

Evidence on tissue expression from TISSUES for N4BP2L1 Gene

  • Nervous system(3.6)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with N4BP2L1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for N4BP2L1 Gene

Orthologs for N4BP2L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for N4BP2L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia N4BP2L1 34 35
  • 98.22 (n)
dog
(Canis familiaris)
Mammalia N4BP2L1 34 35
  • 89.81 (n)
mouse
(Mus musculus)
Mammalia N4bp2l1 34 16 35
  • 83.61 (n)
rat
(Rattus norvegicus)
Mammalia N4bp2l1 34
  • 82.91 (n)
oppossum
(Monodelphis domestica)
Mammalia N4BP2L1 35
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia N4BP2L1 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia N4BP2L1 35
  • 7 (a)
OneToOne
chicken
(Gallus gallus)
Aves N4BP2L1 34 35
  • 73.48 (n)
lizard
(Anolis carolinensis)
Reptilia N4BP2L1 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia n4bp2l1 34
  • 75 (n)
zebrafish
(Danio rerio)
Actinopterygii N4BP2L1 35
  • 19 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7139 35
  • 7 (a)
OneToMany
Species where no ortholog for N4BP2L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for N4BP2L1 Gene

ENSEMBL:
Gene Tree for N4BP2L1 (if available)
TreeFam:
Gene Tree for N4BP2L1 (if available)

Paralogs for N4BP2L1 Gene

Paralogs for N4BP2L1 Gene

(3) SIMAP similar genes for N4BP2L1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with N4BP2L1: view

Variants for N4BP2L1 Gene

Sequence variations from dbSNP and Humsavar for N4BP2L1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000018110 -- 32,427,761(+) TTGGG(A/C)TGGGG intron-variant
rs1000239538 -- 32,418,583(+) AGACC(C/G)CAGAA intron-variant, upstream-variant-2KB
rs1000395110 -- 32,424,609(+) ACAGG(A/C)ATGAG intron-variant, downstream-variant-500B
rs1000526154 -- 32,420,151(+) ATACC(A/T)CCAAA intron-variant, utr-variant-5-prime
rs1000578447 -- 32,419,803(+) CTTAA(A/G)GGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for N4BP2L1 Gene

Variant ID Type Subtype PubMed ID
nsv1070164 CNV deletion 25765185
nsv832576 CNV gain 17160897
nsv976257 CNV duplication 23825009

Variation tolerance for N4BP2L1 Gene

Residual Variation Intolerance Score: 30.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for N4BP2L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
N4BP2L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for N4BP2L1 Gene

Disorders for N4BP2L1 Gene

Relevant External Links for N4BP2L1

Genetic Association Database (GAD)
N4BP2L1
Human Genome Epidemiology (HuGE) Navigator
N4BP2L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
N4BP2L1

No disorders were found for N4BP2L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for N4BP2L1 Gene

Publications for N4BP2L1 Gene

  1. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64
  3. Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. (PMID: 8812419) Couch F.J. … Simard J. (Genomics 1996) 2 3 64
  4. NEDD 4 binding protein 2-like 1 promotes cancer cell invasion in oral squamous cell carcinoma. (PMID: 27184799) Sasahira T. … Kuniyasu H. (Virchows Arch. 2016) 3 64
  5. Genome-wide association studies identify four ER negative-specific breast cancer risk loci. (PMID: 23535733) Garcia-Closas M. … Kraft P. (Nat. Genet. 2013) 3 64

Products for N4BP2L1 Gene

Sources for N4BP2L1 Gene

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