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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

N4BP2L1 Gene

protein-coding GIFtS: 39
GCID: GC13M032974

NEDD4 binding protein 2-like 1

Search for N4BP2L1
in

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our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NEDD4 Binding Protein 2-Like 1¹ ²
CG018¹ ²
Hypothetical Gene CG018²
NEDD4-Binding Protein 2-Like 1²
CG081³

External Ids:	HGNC: 25037¹	Entrez Gene: 90634²	Ensembl: ENSG00000139597⁷	UniProtKB: Q5TBK1³

Export aliases for N4BP2L1 gene to outside databases

Previous GC identifers: GC13M031872 GC13M013786

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the N4BP2L1 gene promoter:
NF-1 Lmo2 AREB6 CREB MEF-2A deltaCREB ARP-1 FOXO1a aMEF-2 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: N4BP2L1 promoter sequence

Search SABiosciences Chromatin IP Primers for N4BP2L1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat N4BP2L1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.1 Ensembl cytogenetic band: 13q13.1 HGNC cytogenetic band: 13q13.1

N4BP2L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
N4BP2L1 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M032974: view genomic region (about GC identifiers)

Start:	32,974,860 bp from pter	End:	33,007,091 bp from pter
Size:	32,232 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: N42L1_HUMAN, Q5TBK1 (See protein sequence)

Recommended Name: NEDD4-binding protein 2-like 1

Size: 243 amino acids; 28981 Da

Secondary accessions: A4QN21 Q5TBK0

Alternative splicing: 2 isoforms: Q5TBK1-1 Q5TBK1-2

Explore the universe of human proteins at neXtProt for N4BP2L1: NX_Q5TBK1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5TBK1

N4BP2L1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001073159.1 NP_438169.2

ENSEMBL proteins:

ENSP00000369484 ENSP00000369476 ENSP00000345838 ENSP00000369473 ENSP00000435515

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

N4BP2L1 for domains About GeneDecksing

1 InterPro domain/family:

IPR026567 NEDD4-bind_pro_2_like_1

Graphical View of Domain Structure for InterPro Entry Q5TBK1

ProtoNet protein and cluster: Q5TBK1

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for N4BP2L1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for N4BP2L1 gene (2 alternative transcripts):

NM_001079691.1 NM_052818.2

Unigene Cluster for N4BP2L1:

NEDD4 binding protein 2-like 1

Hs.732118 [show with all ESTs]

Unigene Representative Sequence: AL832677

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000459716 ENST00000380139 ENST00000380133 ENST00000495479 ENST00000343281

ENST00000472298(uc001uuf.3) ENST00000464470 ENST00000461502 ENST00000380130(uc001uuc.3 uc001uud.3)

ENST00000530622

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Additional cDNA sequence:

AF113009.1 AL049785.1 AL049786.1 AL049787.1 AL049788.1 AL832677.1 BC011650.2 BC022188.2

BC068049.1 BC125050.1 BX648509.1 U50527.1 U50528.1 U57962.1

21 DOTS entries:

DT.95123406 DT.114407 DT.92017106 DT.97796380 DT.121643809 DT.114408 DT.100742701 DT.99985284

DT.95123394 DT.70102467 DT.121643808 DT.92425277 DT.412749 DT.86852729 DT.120793869 DT.120793895

DT.40109676 DT.95085043 DT.97770634 DT.120793922 DT.40256654

24/449 AceView cDNA sequences (see all 449):

AA789152 AI572862 AA278464 BM714657 AA344470 BX502830 BM479613 NM_014887

AA487590 BG287084 AA662487 BQ012091 BP375498 AI581114 AI963956 BX483989

BM456347 BM055268 AI684351 BG742936 AA634635 BP379646 BM543104 AI869207

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

N4BP2L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAGACAAGA

About this image

N4BP2L1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mature follicles (In-vitro growth and ...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See N4BP2L1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for N4BP2L1

SOURCE GeneReport for Unigene cluster: Hs.732118

SABiosciences Custom PCR Arrays for N4BP2L1

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for N4BP2L1 gene from 3/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	N4BP2L1¹	NEDD4 binding protein 2-like 1	74.22(n) 71.82(a)		418914 XM_417110.3 XP_417110.1
lizard (Anolis carolinensis)	Reptilia	N4BP2L1⁶	--	63(a)	1 → many	3(183702383-183718954)
fruit fly (Drosophila melanogaster)	Insecta	CG7139⁶	--	7(a)	1 → many	3L(22060344-22064948)

ENSEMBL Gene Tree for N4BP2L1 (if available)
TreeFam Gene Tree for N4BP2L1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for N4BP2L1 gene

N4BP2²

2 SIMAP similar genes for N4BP2L1 using alignment to 4 protein entries: N42L1_HUMAN (see all proteins):

N4BP2 N4BP2L2

N4BP2L1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs206346^1,2	H,	--	32974370(+)	`AAATAC/TGTTTA`	2	--	ds500¹		6		NS EA NA	418
rs189696583^1,2		--	32974725(+)	`AATGCA/GCACAC`	2	--	ds500¹		0	--	--	--	--
rs182672084^1,2		--	32974764(+)	`GCTACA/TTGAAA`	2	--	ds500¹		0	--	--	--	--
rs151151249^1,2		--	32974789(+)	`TGAGTA/GTATGT`	2	--	ds500¹		0	--	--	--	--
rs73458430^1,2	C,	--	32974880(+)	`GTGTTA/GTTTAT`	2	--	ut3¹		2		WA	120
rs3803282^1,2	C,F,H,	--	32974904(+)	`AATGAG/AACCCT`	2	--	ut3¹		5		NS EA	540
rs140227359^1,2		--	32974991(+)	`CAAAGA/TGTTAC`	2	--	ut3¹		0	--	--	--	--
rs114131293^1,2	F,	--	32975007(+)	`TCAGAA/TGCCAT`	2	--	ut3¹		1		WA	118
rs73173010^1,2	C,	--	32975041(+)	`CTACAG/AGNNNN`	2	--	ut3¹		2		NA	122
rs144172595^1,2		--	32975382(+)	`TGGTTA/CTGCCA`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for N4BP2L1 (32974860 - 33007091 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for N4BP2L1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

N4BP2L1 for disorders About MalaCards

N4BP2L1 for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: N4BP2L1 (2 documents)

Export disorders for N4BP2L1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for N4BP2L1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with N4BP2L1)

Utopia: connect your pdf to the dynamic
world of online information

Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. (PubMed id 8812419)^{1, 3} Couch F.J.... Simard J. (1996)
Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)¹ Guey L.T....Malats N. (2010)
Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)¹ Hosgood H.D....Lan Q. (2009)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)² Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 90634	HGNC: 25037	AceView: PFAAP5	Ensembl:ENSG00000139597	euGenes: HUgn90634
ECgene: N4BP2L1	H-InvDB: N4BP2L1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for N4BP2L1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for N4BP2L1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for N4BP2L1 gene:
Search GeneIP for patents involving N4BP2L1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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N4BP2L1 Gene

NEDD4 binding protein 2-like 1

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N4BP2L1 Gene

NEDD4 binding protein 2-like 1

Aliasesfor N4BP2L1 gene

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Genomic Viewsfor N4BP2L1 gene

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