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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

N4BP2L1 Gene

protein-coding   GIFtS: 40
GCID: GC13M032974

NEDD4 Binding Protein 2-Like 1

  Search for N4BP2L1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NEDD4 Binding Protein 2-Like 11 2
Hypothetical Gene CG0181 2
CG0182
NEDD4-Binding Protein 2-Like 12
CG0813

External Ids:    HGNC: 250371   Entrez Gene: 906342   Ensembl: ENSG000001395977   UniProtKB: Q5TBK13   

Export aliases for N4BP2L1 gene to outside databases

Previous GC identifers: GC13M031872 GC13M013786


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for N4BP2L1 Gene: 
N4BP2L1 (NEDD4 binding protein 2-like 1) is a protein-coding gene. An important paralog of this gene is N4BP2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the N4BP2L1 gene promoter:
         NF-1   Lmo2   AREB6   CREB   MEF-2A   deltaCREB   ARP-1   FOXO1a   aMEF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidN4BP2L1 promoter sequence
   Search SABiosciences Chromatin IP Primers for N4BP2L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat N4BP2L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.1   Ensembl cytogenetic band:  13q13.1   HGNC cytogenetic band: 13q13.1

N4BP2L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
N4BP2L1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M032974:  view genomic region     (about GC identifiers)

Start:
32,974,860 bp from pter      End:
33,002,315 bp from pter
Size:
27,456 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: N42L1_HUMAN, Q5TBK1 (See protein sequence)
Recommended Name: NEDD4-binding protein 2-like 1  
Size: 243 amino acids; 28981 Da
Secondary accessions: A4QN21 Q5TBK0
Alternative splicing: 2 isoforms:  Q5TBK1-1   Q5TBK1-2   

Explore the universe of human proteins at neXtProt for N4BP2L1: NX_Q5TBK1

Explore proteomics data for N4BP2L1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5TBK1

  • N4BP2L1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    N4BP2L1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001073159.1  NP_438169.2  

    ENSEMBL proteins: 
     ENSP00000369484   ENSP00000369476   ENSP00000475237   ENSP00000345838   ENSP00000475443  
     ENSP00000369473   ENSP00000435515  

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    Cloud-Clone Corp. Proteins for N4BP2L1 


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    Cloud-Clone Corp. CLIAs for N4BP2L1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR026567 NEDD4-bind_pro_2_like_1
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q5TBK1

    ProtoNet protein and cluster: Q5TBK1


    N4BP2L1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding ----
    GO:0016301kinase activity ----
         
    N4BP2L1 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidN4BP2L1 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for N4BP2L1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for N4BP2L1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for N4BP2L1 (N42L1)

    Search CenterWatch for drugs/clinical trials and news about N4BP2L1 / N42L1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for N4BP2L1 gene (2 alternative transcripts): 
    NM_001079691.1  NM_052818.2  

    Unigene Cluster for N4BP2L1:

    NEDD4 binding protein 2-like 1
    Hs.732118  [show with all ESTs]
    Unigene Representative Sequence: AL832677
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380139 ENST00000459716 ENST00000380133 ENST00000495479 ENST00000343281
    ENST00000472298(uc001uuf.3) ENST00000464470 ENST00000380130(uc001uuc.3 uc001uud.3)
    ENST00000530622
    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate N4BP2L1 (see all 23):
    hsa-miR-562 hsa-miR-607 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-548s hsa-miR-376a* hsa-miR-591
    SwitchGear 3'UTR luciferase reporter plasmidN4BP2L1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for N4BP2L1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat N4BP2L1
    Clone
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    OriGene clones in human, mouse for N4BP2L1 (see all 12)
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    GenScript: all cDNA clones in your preferred vector (see all 2): N4BP2L1 (NM_052818)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for N4BP2L1
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    Primer
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    OriGene qPCR primer pairs and template standards for N4BP2L1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat N4BP2L1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat N4BP2L1

    Additional mRNA sequence: 

    AF113009.1 AL049785.1 AL049786.1 AL049787.1 AL049788.1 AL832677.1 BC011650.2 BC022188.2 
    BC068049.1 BC125050.1 BX648509.1 U50527.1 U50528.1 U57962.1 

    21 DOTS entries:

    DT.95123406  DT.114407  DT.92017106  DT.97796380  DT.121643809  DT.114408  DT.100742701  DT.99985284 
    DT.95123394  DT.70102467  DT.121643808  DT.92425277  DT.412749  DT.86852729  DT.120793869  DT.120793895 
    DT.40109676  DT.95085043  DT.97770634  DT.120793922  DT.40256654 

    24/449 AceView cDNA sequences (see all 449):

    AI720144 AK123084 BP375498 CB155909 AA662487 BM479613 BM887924 BX484756 
    BQ012091 BQ230890 BU674950 BE465288 AA007302 BT007172 AW299970 BF445839 
    CA432358 CB135577 BM667255 CR596312 BX502830 AA935680 BU680455 AI041412 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    N4BP2L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAGACAAGA
    N4BP2L1 Expression
    About this image


    See N4BP2L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for N4BP2L1

    SOURCE GeneReport for Unigene cluster: Hs.732118
        SABiosciences Custom PCR Arrays for N4BP2L1
    Primer
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    OriGene qPCR primer pairs and template standards for N4BP2L1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for N4BP2L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for N4BP2L1 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia N4bp2l11 , 5 NEDD4 binding protein 2-like 11, 5 86.22(n)1
    86.08(a)1
      5 (89.55 cM)5
    1006371  NM_133898.41  NP_598659.31 
     1505716435 
    chicken
    (Gallus gallus)
    Aves N4BP2L11 NEDD4 binding protein 2-like 1 74.22(n)
    71.82(a)
      418914  XM_417110.3  XP_417110.1 
    lizard
    (Anolis carolinensis)
    Reptilia N4BP2L16
    Uncharacterized protein
    62(a)
    1 ↔ 1
    3(183702383-183718954)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71396
    --
    7(a)
    1 → many
    3L(22060344-22064948)


    ENSEMBL Gene Tree for N4BP2L1 (if available)
    TreeFam Gene Tree for N4BP2L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for N4BP2L1 gene
    N4BP22  
    3 SIMAP similar genes for N4BP2L1 using alignment to 3 protein entries:     N42L1_HUMAN (see all proteins):
    92M18.2    N4BP2L2    N4BP2

    N4BP2L1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/580 SNPs in N4BP2L1 are shown (see all 580)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2063461,2
    F,H--32974370(+) AAATAC/TGTTTA 2 -- ds50016Minor allele frequency- T:0.00NS EA NA 418
    rs1896965831,2
    --32974725(+) AATGCA/GCACAC 2 -- ds50010--------
    rs1826720841,2
    --32974764(+) GCTACA/TTGAAA 2 -- ds50010--------
    rs1511512491,2
    --32974789(+) TGAGTA/GTATGT 2 -- ds50010--------
    rs734584301,2
    C,F--32974880(+) GTGTTA/GTTTAT 2 -- ut312Minor allele frequency- G:0.01WA 120
    rs38032821,2
    C,F,H--32974904(+) AATGAG/AACCCT 2 -- ut315Minor allele frequency- A:0.01NS EA 540
    rs1402273591,2
    --32974991(+) CAAAGA/TGTTAC 2 -- ut310--------
    rs1141312931,2
    C,F--32975007(+) TCAGAA/TGCCAT 2 -- ut311Minor allele frequency- T:0.03WA 118
    rs731730101,2
    C--32975041(+) CTACAG/AGGGAT 2 -- ut312Minor allele frequency- A:0.13NA 122
    rs1441725951,2
    C--32975382(+) TGGTTA/CTGCCA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for N4BP2L1 (32974860 - 33002315 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for N4BP2L1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832576CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    N4BP2L1 for disorders           About MalaCards

    N4BP2L1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): N4BP2L1
    Human Genome Epidemiology (HuGE) Navigator: N4BP2L1 (2 documents)

    Export disorders for N4BP2L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for N4BP2L1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with N4BP2L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    2. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    3. Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. (PubMed id 8812419)1, 3 Couch F.J.... Simard J. (1996)
    4. Large-scale genotyping identifies 41 new loci associat ed with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (2013)
    5. Genome-wide association studies identify four ER negat ive-specific breast cancer risk loci. (PubMed id 23535733)1 Garcia-Closas M....Kraft P. (2013)
    6. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90634 HGNC: 25037 AceView: PFAAP5 Ensembl:ENSG00000139597 euGenes: HUgn90634
    ECgene: N4BP2L1 H-InvDB: N4BP2L1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for N4BP2L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for N4BP2L1 gene:
    Search GeneIP for patents involving N4BP2L1

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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