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Aliases for N4BP2 Gene

Aliases for N4BP2 Gene

  • NEDD4 Binding Protein 2 2 3 5
  • BCL-3-Binding Protein 3 4
  • B3BP 3 4
  • BCL-3 Binding Protein 2
  • EC 3.-.-.- 4
  • KIAA1413 4

External Ids for N4BP2 Gene

Previous GeneCards Identifiers for N4BP2 Gene

  • GC04P040068
  • GC04P040266
  • GC04P039893
  • GC04P039996
  • GC04P039972
  • GC04P039897
  • GC04P039734
  • GC04P039775
  • GC04P039381

Summaries for N4BP2 Gene

Entrez Gene Summary for N4BP2 Gene

  • This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for N4BP2 Gene

N4BP2 (NEDD4 Binding Protein 2) is a Protein Coding gene. GO annotations related to this gene include endonuclease activity and ATP-dependent polydeoxyribonucleotide 5-hydroxyl-kinase activity. An important paralog of this gene is N4BP2L1.

UniProtKB/Swiss-Prot for N4BP2 Gene

  • Has 5-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for N4BP2 Gene

Genomics for N4BP2 Gene

Regulatory Elements for N4BP2 Gene

Promoters for N4BP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around N4BP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for N4BP2 Gene

Chromosome:
4
Start:
40,056,212 bp from pter
End:
40,185,798 bp from pter
Size:
129,587 bases
Orientation:
Plus strand

Genomic View for N4BP2 Gene

Genes around N4BP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
N4BP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for N4BP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for N4BP2 Gene

Proteins for N4BP2 Gene

  • Protein details for N4BP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UW6-N4BP2_HUMAN
    Recommended name:
    NEDD4-binding protein 2
    Protein Accession:
    Q86UW6
    Secondary Accessions:
    • A0AVR3
    • Q9NVK2
    • Q9P2D4

    Protein attributes for N4BP2 Gene

    Size:
    1770 amino acids
    Molecular mass:
    198801 Da
    Quaternary structure:
    • Binds NEDD4 (By similarity). Binds BCL3 and CREBBP.

    Three dimensional structures from OCA and Proteopedia for N4BP2 Gene

    Alternative splice isoforms for N4BP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for N4BP2 Gene

Proteomics data for N4BP2 Gene at MOPED

Post-translational modifications for N4BP2 Gene

  • Ubiquitinated; this targets the protein for degradation by the proteasome.
  • Ubiquitination at Lys 20, Lys 414, Lys 453, Lys 1160, Lys 1247, Lys 1440, and Lys 1459
  • Modification sites at PhosphoSitePlus

Other Protein References for N4BP2 Gene

No data available for DME Specific Peptides for N4BP2 Gene

Domains & Families for N4BP2 Gene

Protein Domains for N4BP2 Gene

Suggested Antigen Peptide Sequences for N4BP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UW6

UniProtKB/Swiss-Prot:

N4BP2_HUMAN :
  • The Smr domain has nicking endonuclease activity, but no significant double strand cleavage or exonuclease activity.
Domain:
  • The Smr domain has nicking endonuclease activity, but no significant double strand cleavage or exonuclease activity.
  • Contains 1 CUE domain.
  • Contains 1 Smr domain.
genes like me logo Genes that share domains with N4BP2: view

No data available for Gene Families for N4BP2 Gene

Function for N4BP2 Gene

Molecular function for N4BP2 Gene

UniProtKB/Swiss-Prot Function:
Has 5-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.

Enzyme Numbers (IUBMB) for N4BP2 Gene

Gene Ontology (GO) - Molecular Function for N4BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 12730195
GO:0046404 ATP-dependent polydeoxyribonucleotide 5-hydroxyl-kinase activity IDA 12730195
genes like me logo Genes that share ontologies with N4BP2: view
genes like me logo Genes that share phenotypes with N4BP2: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for N4BP2 Gene

Localization for N4BP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for N4BP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for N4BP2 Gene COMPARTMENTS Subcellular localization image for N4BP2 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2
plasma membrane 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for N4BP2 Gene

Pathways & Interactions for N4BP2 Gene

SuperPathways for N4BP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for N4BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IDA 12730195
genes like me logo Genes that share ontologies with N4BP2: view

No data available for Pathways by source and SIGNOR curated interactions for N4BP2 Gene

Drugs & Compounds for N4BP2 Gene

No Compound Related Data Available

Transcripts for N4BP2 Gene

Unigene Clusters for N4BP2 Gene

NEDD4 binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for N4BP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6: - - -

Relevant External Links for N4BP2 Gene

GeneLoc Exon Structure for
N4BP2
ECgene alternative splicing isoforms for
N4BP2

Expression for N4BP2 Gene

mRNA expression in normal human tissues for N4BP2 Gene

Protein differential expression in normal tissues from HIPED for N4BP2 Gene

This gene is overexpressed in Liver, secretome (20.2), Colon muscle (17.2), Plasma (15.0), and Serum (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for N4BP2 Gene



SOURCE GeneReport for Unigene cluster for N4BP2 Gene Hs.391463

genes like me logo Genes that share expression patterns with N4BP2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for N4BP2 Gene

Orthologs for N4BP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for N4BP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia N4BP2 35
  • 86.97 (n)
  • 81.56 (a)
N4BP2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia N4BP2 35
  • 88.4 (n)
  • 82.69 (a)
N4BP2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia N4bp2 35
  • 78.58 (n)
  • 72.18 (a)
N4bp2 16
N4bp2 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia N4BP2 35
  • 99.66 (n)
  • 99.6 (a)
N4BP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia N4bp2 35
  • 79.31 (n)
  • 72.99 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia N4BP2 36
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves N4BP2 35
  • 58.37 (n)
  • 47.63 (a)
N4BP2 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia N4BP2 36
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3753 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.20151 35
zebrafish
(Danio rerio)
Actinopterygii n4bp2 36
  • 29 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7139 36
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
Species with no ortholog for N4BP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for N4BP2 Gene

ENSEMBL:
Gene Tree for N4BP2 (if available)
TreeFam:
Gene Tree for N4BP2 (if available)

Paralogs for N4BP2 Gene

Paralogs for N4BP2 Gene

(2) SIMAP similar genes for N4BP2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for N4BP2 Gene

genes like me logo Genes that share paralogs with N4BP2: view

Variants for N4BP2 Gene

Sequence variations from dbSNP and Humsavar for N4BP2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_035474 A breast cancer sample
rs17511668 - 40,102,147(+) ACAAA(G/T)TTTCG reference, missense
rs10014170 - 40,102,431(+) AAAAT(A/G)TGAAT reference, missense
rs794001 - 40,119,942(+) GAGAC(A/G)ATGAA reference, missense
rs2271395 - 40,137,056(-) GCCAG(C/T)ATGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for N4BP2 Gene

Variant ID Type Subtype PubMed ID
nsv461341 CNV Gain 19166990
nsv878955 CNV Loss 21882294
esv29217 CNV Loss 19812545
nsv878956 CNV Gain 21882294

Variation tolerance for N4BP2 Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.86; 89.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for N4BP2 Gene

HapMap Linkage Disequilibrium report
N4BP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for N4BP2 Gene

Disorders for N4BP2 Gene

Relevant External Links for N4BP2

Genetic Association Database (GAD)
N4BP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
N4BP2

No disorders were found for N4BP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for N4BP2 Gene

Publications for N4BP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Haplotype of gene Nedd4 binding protein 2 associated with sporadic nasopharyngeal carcinoma in the Southern Chinese population. (PMID: 17626640) Zheng M.Z. … Zeng Y.X. (J Transl Med 2007) 3 23
  3. Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. (PMID: 11717310) Murillas R. … Kuehn M.R. (J. Biol. Chem. 2002) 2 3
  4. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3
  5. Modulated nicking endonuclease function by the N-terminal extended region of the smr domain in human Bcl-3 binding protein. (PMID: 22072629) Jeong E.Y. … Ban C. (Proteins 2012) 3

Products for N4BP2 Gene

Sources for N4BP2 Gene

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