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Aliases & Descriptions for N4BP2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| B3BP 1, 2, 3 | | EC 3.-.-.- 3 | | FLJ10680 2 | | KIAA1413 2, 3 | | OTTHUMP00000158757 2 |
| | | Descriptions |
|---|
| BCL-3 binding protein 2 | | BCL-3-binding protein 3 | | NEDD4 binding protein 2 2 |
|
| | Search outside databases for aliases for N4BP2 genePrevious GC identifers: GC04P040068 GC04P040266 GC04P039893 GC04P039996 GC04P039972 GC04P039897 |
Summaries for N4BP2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for N4BP2: This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. [provided by RefSeq] UniProtKB/Swiss-Prot: N4BP2_HUMAN, Q86UW6Function: Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination |
Genomic Location for N4BP2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the N4BP2 gene 
Entrez Gene cytogenetic band: 4p14 Ensembl cytogenetic band: 4p14 HGNC cytogenetic band: 4p14N4BP2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P039734:
(about GC identifiers)
Start:
|
39,734,919 bp from pter |
End:
|
39,836,267 bp from pter |
Size:
|
101,349 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000004.10 NT_016297.15
| Proteins for N4BP2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: N4BP2_HUMAN, Q86UW6 (See
protein sequence)Recommended Name: NEDD4-binding protein 2 Size: 1770 amino acids; 198801 Da
Subunit: Binds NEDD4 (By similarity). Binds BCL3 and CREBBP
Subcellular location: Cytoplasm (By similarity)
PDB structures from and Proteopedia :2D9I (3D)
 2VKC (3D)
 3BHB (3D)
 
Secondary accessions: A0AVR3 Q9NVK2 Q9P2D4Alternative splicing: 2 isoforms: Q86UW6-1 Q86UW6-2 Post-translational modifications:
Ubiquitinated; this targets the protein for degradation by the proteasome (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_060647.2
ENSEMBL proteins: ENSP00000371225 ENSP00000261435
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | About this table
Antibodies for N4BP2: Assays for N4BP2: | Protein
Domains/ Families for N4BP2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q86UW6
ProtoNet protein and cluster: Q86UW6 2 Blocks protein families: IPB002625 Smr protein/MutS2 C-terminal IPB003892 Ubiquitin system component Cue
UniProtKB/Swiss-Prot: N4BP2_HUMAN, Q86UW6Domain: The Smr domain has nicking endonuclease activity, but no significant double strand cleavage or exonuclease activitySimilarity: Contains 1 CUE domainSimilarity: Contains 1 Smr domain | Gene Function for N4BP2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018177
Applied Biosystems Silencer® siRNAs for N4BP2
Sigma-Aldrich siRNA for N4BP2  Sigma-Aldrich shRNA for N4BP2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018177                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018177                                  untagged cDNA clones in CMV expression vector (see all 2): NM_018177 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018177
UniProtKB/Swiss-Prot: N4BP2_HUMAN, Q86UW6Function: Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombinationEnzyme Number (IUBMB): EC 3.-.-.- 5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for N4BP2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for N4BP2 
2 Interacting proteins for N4BP2 (ENSP000002614353) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds for N4BP2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for N4BP2
|
Transcripts for N4BP2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018177
Sigma-Aldrich siRNA for N4BP2  Sigma-Aldrich shRNA for N4BP2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_018177 REFSEQ mRNAs for N4BP2 gene: NM_018177.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018177               OriGene GFP tagged cDNA clone in CMV expression vector: NM_018177                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018177                                  untagged cDNA clones in CMV expression vector (see all 2): NM_018177  Additional cDNA sequence: AB037834.1 AB371584.1 AK001542.1 AY267013.1 BC126466.1 6 DOTS entries: DT.410570 DT.95070779 DT.99962520 DT.309401 DT.95303939 DT.95303940 24/80 AceView cDNA sequences (see all 80
):AB037834 BQ008834 BM804242 BE856543 BE550411 H03459 AI278279 AI973227 NM_018177 AA598849 F05693 AK001542 R93882 BU161412 BX503904 BE887093 BM468557 CD642915 CD522214 R57027 BF107284 BX409876 BM460199 AI831502
highest scoring ESTs for N4BP2:AA699681 AB037834 AI393829 AI655142 BG389188 BM791313 BX503904 N70425 R54310 W93336 Unigene Cluster for N4BP2: NEDD4 binding protein 2 Hs.391463 [show with all ESTs]Unigene Representative Sequence: AB371584
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for N4BP2 (see all 6
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | |
| SP1: | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for N4BP2
2 Ensembl transcripts including schematic representations: ENST00000381804
ENST00000261435
|
Expression for N4BP2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| N4BP2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for N4BP2
1 / 2 / 3 8 probe-sets matching N4BP2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GTGAATCCCC
SOURCE GeneReport for Unigene cluster: Hs.391463
|
Orthologs for N4BP2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for N4BP2 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for N4BP2
ENSEMBL Gene Tree for N4BP2 | Paralogs for N4BP2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for N4BP2 gene
- N4BP2L12
|
SNPs/Variants for N4BP2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for N4BP2 (up to first 250kb)
|
Disorders & Mutations for N4BP2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for N4BP2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for N4BP2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/11 PubMed articles for N4BP2 gene (see all 11
):- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)2, 3, 4 Nagase T....Ohara O. (2000)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination. (PubMed id 12730195)3, 4 Watanabe N.... Fujita T. (2003)
- Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. (PubMed id 11717310)2, 3 Murillas R....Kuehn M.R. (2002)
- Fine Expression Profiling of Full-length Transcripts using a Size-unbiased cDNA Library Prepared with the Vector-capping Method. (PubMed id 18487259)3 Oshikawa M....Kato S. (2008)
- Solution structure and characterization of the DNA-binding activity of the B3BP-Smr domain. (PubMed id 18804481)3 Diercks T....Folkers G.E. (2008)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)4 Sjoeblom T.... Velculescu V.E. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for N4BP2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing N4BP2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing N4BP2
(According to HUGE)
About This Section
| |
Specialized Databases showing N4BP2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for N4BP2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for N4BP2:

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Incremental update: 13 Oct 2009
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