Aliases for N4BP2 Gene
External Ids for N4BP2 Gene
Previous GeneCards Identifiers for N4BP2 Gene
This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
GeneCards Summary for N4BP2 Gene
N4BP2 (NEDD4 Binding Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include endonuclease activity and ATP-dependent polydeoxyribonucleotide 5-hydroxyl-kinase activity. An important paralog of this gene is N4BP2L2.
UniProtKB/Swiss-Prot for N4BP2 Gene
Has 5-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.