Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

N4BP1 Gene

protein-coding   GIFtS: 50
GCID: GC16M048572

NEDD4 Binding Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NEDD4 Binding Protein 11 2
NEDD4-Binding Protein 12
KIAA06153

External Ids:    HGNC: 298501   Entrez Gene: 96832   Ensembl: ENSG000001029217   UniProtKB: O751133   

Export aliases for N4BP1 gene to outside databases

Previous GC identifers: GC16M038991 GC16M048624 GC16M048311 GC16M048354 GC16M047131 GC16M034461


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for N4BP1 Gene: 
N4BP1 (NEDD4 binding protein 1) is a protein-coding gene. Diseases associated with N4BP1 include chronic lymphocytic leukemia, and rheumatoid arthritis. GO annotations related to this gene include protein binding. An important paralog of this gene is NYNRIN.

UniProtKB/Swiss-Prot: N4BP1_HUMAN, O75113
Function: Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of
ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the N4BP1 gene promoter:
         HSF1 (long)   RelA   POU6F1 (c2)   NF-kappaB   YY1   Max   c-Rel   Cart-1   HSF1short   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidN4BP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for N4BP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat N4BP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.1   Ensembl cytogenetic band:  16q12.1   HGNC cytogenetic band: 16q12.1

N4BP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
N4BP1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M048572:  view genomic region     (about GC identifiers)

Start:
48,572,637 bp from pter      End:
48,654,059 bp from pter
Size:
81,423 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: N4BP1_HUMAN, O75113 (See protein sequence)
Recommended Name: NEDD4-binding protein 1  
Size: 896 amino acids; 100379 Da
Subunit: Interacts with NEDD4. Interacts with ITCH (via WW domain 2) (By similarity)
Subcellular location: Nucleus, nucleolus (By similarity). Nucleus, PML body (By similarity). Note=Primarily
localizes to the nucleolus. Also localizes to the PML nuclear bodies, when desumoylated (By similarity)
Sequence caution: Sequence=BAA31590.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7MD49 Q2YDX1

Explore the universe of human proteins at neXtProt for N4BP1: NX_O75113

Explore proteomics data for N4BP1 at MOPED 

Post-translational modifications:

  • UniProtKB: Monoubiquitinated by NEDD4. Polyubiquitinated, leading to its degradation by the proteasome. Sumoylated with
    SUMO1, abrogating polyubiquitination and subsequent degradation. Desumoylated by SENP1, leading to accumulation
    in PML nuclear bodies (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75113

  • N4BP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    N4BP1 Protein Expression
    REFSEQ proteins: NP_694574.3  
    ENSEMBL proteins: 
     ENSP00000262384   ENSP00000460667  

    Human Recombinant Protein Products for N4BP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for N4BP1
    GenScript Custom Purified and Recombinant Proteins Services for N4BP1
    Novus Biologicals N4BP1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for N4BP1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus ISS--
    GO:0016605PML body ISS--

    N4BP1 for ontologies           About GeneDecksing



    N4BP1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for N4BP1
    GenScript Custom Superior Antibodies Services for N4BP1
    Novus Biologicals N4BP1 Antibodies
    Abcam antibodies for N4BP1
    Cloud-Clone Corp. Antibodies for N4BP1 
    ThermoFisher Antibody for N4BP1
    LSBio Antibodies in human, mouse, rat for N4BP1 

    Assay Products for N4BP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for N4BP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for N4BP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for N4BP1 
    Cloud-Clone Corp. CLIAs for N4BP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR021869 RNase_Zc3h12

    Graphical View of Domain Structure for InterPro Entry O75113

    ProtoNet protein and cluster: O75113

    UniProtKB/Swiss-Prot: N4BP1_HUMAN, O75113
    Similarity: Belongs to the N4BP1 family


    N4BP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: N4BP1_HUMAN, O75113
    Function: Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of
    ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    N4BP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for N4BP1:
     Increased HPV18 LCR reporter a 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for N4bp1):
     no phenotypic analysis 

    N4BP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out N4bp1tm1.1Mku for N4BP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for N4BP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for N4BP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for N4BP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for N4BP1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat N4BP1
    8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate N4BP1 (see all 83):
    hsa-miR-3607-3p hsa-miR-15a hsa-miR-128 hsa-miR-134 hsa-miR-3653 hsa-miR-519a hsa-miR-3921 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidN4BP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for N4BP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat N4BP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for N4BP1
    Sirion Biotech Customized adenovirus for overexpression of N4BP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for N4BP1 (see all 6)
    OriGene ORF clones in mouse, rat for N4BP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: N4BP1 (NM_153029)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for N4BP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat N4BP1
    Sirion Biotech Customized lentivirus for stable overexpression of N4BP1 
                         Customized lentivirus expression plasmids for stable overexpression of N4BP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for N4BP1
    Search LifeMap BioReagents cell lines for N4BP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for N4BP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for N4BP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/8 Interacting proteins for N4BP1 (O751131, 2, 3 ENSP000002623844) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J023, ENSP000003639984I2D: score=2 STRING: ENSP00000363998
    UBCP0CG483, ENSP000003448184I2D: score=2 STRING: ENSP00000344818
    LSM1O151163, ENSP000003105964I2D: score=1 STRING: ENSP00000310596
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    AZI2Q9H6S13, ENSP000004193714I2D: score=1 STRING: ENSP00000419371
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031397negative regulation of protein ubiquitination ISS--
    GO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISS--
    GO:0034644cellular response to UV IMP17592138

    N4BP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for N4BP1

    Search CenterWatch for drugs/clinical trials and news about N4BP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for N4BP1 gene: 
    NM_153029.3  

    Unigene Cluster for N4BP1:

    NEDD4 binding protein 1
    Hs.511839  [show with all ESTs]
    Unigene Representative Sequence: NM_153029
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262384(uc002efp.3) ENST00000565423 ENST00000569027 ENST00000564124
    ENST00000565638 ENST00000564710
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat N4BP1
    8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate N4BP1 (see all 83):
    hsa-miR-3607-3p hsa-miR-15a hsa-miR-128 hsa-miR-134 hsa-miR-3653 hsa-miR-519a hsa-miR-3921 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidN4BP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for N4BP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat N4BP1
    Clone
    Products:
         
    OriGene clones in human, mouse for N4BP1 (see all 6)
    OriGene ORF clones in mouse, rat for N4BP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: N4BP1 (NM_153029)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for N4BP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat N4BP1
    Sirion Biotech Customized lentivirus for stable overexpression of N4BP1 
                         Customized lentivirus expression plasmids for stable overexpression of N4BP1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for N4BP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat N4BP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat N4BP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat N4BP1

    Additional mRNA sequence: 

    AB014515.1 AK001464.1 AK026937.1 AK056383.1 AK094234.1 AK124782.1 AL831882.1 BC051897.1 
    BC108288.1 BC152472.1 

    8 DOTS entries:

    DT.213542  DT.75103885  DT.112202  DT.209678  DT.86854338  DT.95369347  DT.91713557  DT.40119828 

    24/179 AceView cDNA sequences (see all 179):

    AL831882 BM547703 BU160325 BU507195 NM_153029 AL523704 CA393960 AI199182 
    BU521373 AK056383 BM717970 BE888432 CB154742 AI248182 BQ962044 AA370025 
    AI379495 BC051897 AI080226 BF510260 CF264999 AA919039 BM968473 AA911171 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for N4BP1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:        -                                                         
    SP2:                                                  -               
    SP3:                                                                  


    ECgene alternative splicing isoforms for N4BP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    N4BP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTTGTGAC
    N4BP1 Expression
    About this image


    See N4BP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for N4BP1

    SOURCE GeneReport for Unigene cluster: Hs.511839

    UniProtKB/Swiss-Prot: N4BP1_HUMAN, O75113
    Tissue specificity: Detected in heart, lung, brain, liver, skeletal muscle, pancreas, kidney, spleen, testis and
    ovary

        SABiosciences Custom PCR Arrays for N4BP1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for N4BP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat N4BP1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat N4BP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat N4BP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for N4BP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for N4BP1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia N4bp11 , 5 NEDD4 binding protein 11, 5 83.28(n)1
    81.41(a)1
      8 (42.10 cM)5
    807501  NM_030563.21  NP_085040.21 
     868411395 
    chicken
    (Gallus gallus)
    Aves N4BP11 NEDD4 binding protein 1 64.48(n)
    58.36(a)
      415739  NM_001030570.1  NP_001025741.1 
    lizard
    (Anolis carolinensis)
    Reptilia N4BP16
    Uncharacterized protein
    51(a)
    1 ↔ 1
    GL343469.1(619914-637381)
    African clawed frog
    (Xenopus laevis)
    Amphibia n4bp1-pending-prov2 Nedd4 binding protein 1 71.26(n)    BC045006.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi03b052 wufi03b05 75.32(n)   327327  BC059205.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG423606
    --
    18(a)
    1 → many
    2R(20494812-20498049)


    ENSEMBL Gene Tree for N4BP1 (if available)
    TreeFam Gene Tree for N4BP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for N4BP1 gene
    NYNRIN2  ZC3H12C2  ZC3H12B2  ZC3H12D2  KHNYN2  ZC3H12A2  

    N4BP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1416 SNPs in N4BP1 are shown (see all 1416)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1168798881,2
    F--34468460(+) GCATGT/CTGGAG 1 -- int11Minor allele frequency- C:0.02EA 120
    rs1848567891,2
    --34468503(+) AACTTC/TAGGCT 1 -- int10--------
    rs1399649671,2
    --34468517(+) AACCAC/GCTCTT 1 -- int10--------
    rs1453779221,2
    --34468524(+) TCTTCA/GAACTT 1 -- int10--------
    rs1881207031,2
    --34468591(+) ATGTTG/TCAGGC 1 -- int10--------
    rs740179701,2
    C--34468605(+) ACCATC/TGGTGT 1 -- int12Minor allele frequency- T:0.05WA 120
    rs1476735941,2
    --34468628(+) AGTACA/GTGCTC 1 -- int10--------
    rs169462131,2
    C,F,H--34468694(+) AATGTC/GCTAGT 1 -- int18Minor allele frequency- G:0.01NA NS EA WA 674
    rs1116715111,2
    C--34468696(+) TGTCCT/CAGTGG 1 -- int12Minor allele frequency- C:0.13CSA WA 120
    rs745019211,2
    C,F--34468782(+) TGTGGA/TGCCAC 1 -- int12Minor allele frequency- T:0.13CSA WA 120

    HapMap Linkage Disequilibrium report for N4BP1 (48572637 - 48654059 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for N4BP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv33450CNV Gain17666407

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing N4BP1
    DNA2.0 Custom Variant and Variant Library Synthesis for N4BP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for N4BP1:    About MalaCards
    chronic lymphocytic leukemia    rheumatoid arthritis    arthritis    leukemia


    N4BP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): N4BP1
    Human Genome Epidemiology (HuGE) Navigator: N4BP1 (1 document)

    Export disorders for N4BP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for N4BP1 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with N4BP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
    2. Genome-wide association analysis implicates the involv ement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PubMed id 22491018)1, 4 Wang J....Platt A. (2012)
    3. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (2008)
    4. Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. (PubMed id 11717310)1, 3 Murillas R.... Kuehn M.R. (2002)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    8. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9683 HGNC: 29850 AceView: N4BP1 Ensembl:ENSG00000102921 euGenes: HUgn9683
    ECgene: N4BP1 H-InvDB: N4BP1

    (According to HUGE)
    About This Section
    HUGE: KIAA0615

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for N4BP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for N4BP1 gene:
    Search GeneIP for patents involving N4BP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for N4BP1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for N4BP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for N4BP1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for N4BP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for N4BP1   OriGene Custom Protein Services for N4BP1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat N4BP1
     QIAGEN SeqTarget long-range PCR primers for resequencing N4BP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat N4BP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat N4BP1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat N4BP1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat N4BP1
     GenScript Custom Purified and Recombinant Proteins Services for N4BP1 GenScript cDNA clones with any tag delivered in your preferred vector for N4BP1
     GenScript Custom Assay Services for N4BP1 GenScript Custom Superior Antibodies Services for N4BP1
     GenScript Custom overexpressing Cell Line Services for N4BP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in N4BP1 promoter
     Search Chromatin IP Primers for N4BP1
     RT2 qPCR Primer Assay in human, mouse, rat N4BP1
     Search GNC Networks for N4BP1
     SABiosciences Custom PCR Arrays for N4BP1
     Search Tocris compounds for N4BP1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     N4BP1 antibodies
     N4BP1 proteins
     Antibodies for N4BP1
     See all of Abcam's Antibodies, Kits and Proteins for N4BP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for N4BP1
     Antibodies for N4BP1
     ELISAs for N4BP1
     CLIAs for N4BP1
     Search LifeMap BioReagents cell lines for N4BP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for N4BP1
     SwitchGear 3'UTR luciferase reporter plasmids for N4BP1
     SwitchGear Promoter luciferase reporter plasmids for N4BP1
     ThermoFisher Antibody for N4BP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat N4BP1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for N4BP1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for N4BP1
    Customized:
     lentivirus for stable overexpression of N4BP1
     lentivirus expression plasmids for stable overexpression of N4BP1
     adenovirus for overexpression of N4BP1
     LSBio Antibodies in human, mouse, rat for N4BP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      N4BP1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4