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N4BP1 Gene

protein-coding   GIFtS: 51
GCID: GC16M048572

NEDD4 Binding Protein 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NEDD4 Binding Protein 11 2
NEDD4-Binding Protein 12
KIAA06153

External Ids:    HGNC: 298501   Entrez Gene: 96832   Ensembl: ENSG000001029217   UniProtKB: O751133   

Export aliases for N4BP1 gene to outside databases

Previous GC identifers: GC16M038991 GC16M048624 GC16M048311 GC16M048354 GC16M047131 GC16M034461


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for N4BP1 Gene:
N4BP1 (NEDD4 binding protein 1) is a protein-coding gene. An important paralog of this gene is NYNRIN.

UniProtKB/Swiss-Prot: N4BP1_HUMAN, O75113
Function: Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of
ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the N4BP1 gene promoter:
         HSF1 (long)   RelA   POU6F1 (c2)   NF-kappaB   YY1   Max   c-Rel   Cart-1   HSF1short   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidN4BP1 promoter sequence
   Search Chromatin IP Primers for N4BP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat N4BP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.1   Ensembl cytogenetic band:  16q12.1   HGNC cytogenetic band: 16q12.1

N4BP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
N4BP1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M048572:  view genomic region     (about GC identifiers)

Start:
48,572,637 bp from pter      End:
48,654,059 bp from pter
Size:
81,423 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: N4BP1_HUMAN, O75113 (See protein sequence)
Recommended Name: NEDD4-binding protein 1  
Size: 896 amino acids; 100379 Da
Subunit: Interacts with NEDD4. Interacts with ITCH (via WW domain 2) (By similarity)
Sequence caution: Sequence=BAA31590.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7MD49 Q2YDX1

Explore the universe of human proteins at neXtProt for N4BP1: NX_O75113

Explore proteomics data for N4BP1 at MOPED

Post-translational modifications: 

  • Monoubiquitinated by NEDD4. Polyubiquitinated, leading to its degradation by the proteasome. Sumoylated with
    SUMO1, abrogating polyubiquitination and subsequent degradation. Desumoylated by SENP1, leading to accumulation
    in PML nuclear bodies (By similarity)1
  • Ubiquitination2 at Lys297, Lys412, Lys441, Lys471, Lys601, Lys714, Lys773
  • Modification sites at PhosphoSitePlus

  • See N4BP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_694574.3  
    ENSEMBL proteins: 
     ENSP00000262384   ENSP00000460667  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR021869 RNase_Zc3h12

    Graphical View of Domain Structure for InterPro Entry O75113

    ProtoNet protein and cluster: O75113

    UniProtKB/Swiss-Prot: N4BP1_HUMAN, O75113
    Similarity: Belongs to the N4BP1 family


    Find genes that share domains with N4BP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: N4BP1_HUMAN, O75113
    Function: Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of
    ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with N4BP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for N4BP1:
     Increased HPV18 LCR reporter a 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for N4bp1):
     no phenotypic analysis 

    Find genes that share phenotypes with N4BP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out N4bp1tm1.1Mku for N4BP1

       genOway: Develop your customized and physiologically relevant rodent model for N4BP1

    miRNA
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    miRTarBase miRNAs that target N4BP1:
    hsa-mir-28-5p (MIRT006411), hsa-mir-93-5p (MIRT048847), hsa-mir-16-5p (MIRT031453), hsa-mir-320b (MIRT036205), hsa-mir-708-3p (MIRT006412), hsa-mir-151a-5p (MIRT006413), hsa-mir-103a-3p (MIRT027038)

    Block miRNA regulation of human, mouse, rat N4BP1 using miScript Target Protectors
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    hsa-miR-3607-3p hsa-miR-15a hsa-miR-128 hsa-miR-134 hsa-miR-3653 hsa-miR-519a hsa-miR-3921 hsa-miR-130b
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    N4BP1_HUMAN, O75113: Nucleus, nucleolus (By similarity). Nucleus, PML body (By similarity). Note=Primarily
    localizes to the nucleolus. Also localizes to the PML nuclear bodies, when desumoylated (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    cytoskeleton1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus ISS--
    GO:0016605PML body ISS--

    Find genes that share ontologies with N4BP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for N4BP1
    Interactions:

        Search GeneGlobe Interaction Network for N4BP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for N4BP1 (O751131, 2, 3 ENSP000002623844) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J023, ENSP000003639984I2D: score=2 STRING: ENSP00000363998
    UBCP0CG483, ENSP000003448184I2D: score=2 STRING: ENSP00000344818
    LSM1O151163, ENSP000003105964I2D: score=1 STRING: ENSP00000310596
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    AZI2Q9H6S13, ENSP000004193714I2D: score=1 STRING: ENSP00000419371
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031397negative regulation of protein ubiquitination ISS--
    GO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISS--
    GO:0034644cellular response to UV IMP17592138

    Find genes that share ontologies with N4BP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for N4BP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for N4BP1 gene: 
    NM_153029.3  

    Unigene Cluster for N4BP1:

    NEDD4 binding protein 1
    Hs.511839  [show with all ESTs]
    Unigene Representative Sequence: NM_153029
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262384(uc002efp.3) ENST00000565423 ENST00000569027 ENST00000564124
    ENST00000565638 ENST00000564710
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    Selected qRT-PCR Assays for microRNAs that regulate N4BP1 (see all 83):
    hsa-miR-3607-3p hsa-miR-15a hsa-miR-128 hsa-miR-134 hsa-miR-3653 hsa-miR-519a hsa-miR-3921 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidN4BP1 3' UTR sequence
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    Additional mRNA sequence: 

    AB014515.1 AK001464.1 AK026937.1 AK056383.1 AK094234.1 AK124782.1 AL831882.1 BC051897.1 
    BC108288.1 BC152472.1 

    8 DOTS entries:

    DT.213542  DT.75103885  DT.112202  DT.209678  DT.86854338  DT.95369347  DT.91713557  DT.40119828 

    Selected AceView cDNA sequences (see all 179):

    BM830152 AA316977 BM968473 AA631580 AA911171 F13171 AI080511 BM673246 
    AI332705 AI017927 F13173 BM547703 AL831882 AK001464 BM677178 F13180 
    BX477474 BQ000756 AB014515 BF512689 AL046130 BM707079 BF509350 AI800356 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for N4BP1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:        -                                                         
    SP2:                                                  -               
    SP3:                                                                  


    ECgene alternative splicing isoforms for N4BP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    N4BP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTTGTGAC
    N4BP1 Expression
    About this image

    N4BP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    N4BP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.511839

    UniProtKB/Swiss-Prot: N4BP1_HUMAN, O75113
    Tissue specificity: Detected in heart, lung, brain, liver, skeletal muscle, pancreas, kidney, spleen, testis and
    ovary

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for N4BP1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia N4bp11 , 5 NEDD4 binding protein 11, 5 83.17(n)1
    81.41(a)1
      8 (42.10 cM)5
    807501  NM_030563.21  NP_085040.21 
     868411395 
    chicken
    (Gallus gallus)
    Aves N4BP11 NEDD4 binding protein 1 64.04(n)
    58.58(a)
      415739  NM_001030570.1  NP_001025741.1 
    lizard
    (Anolis carolinensis)
    Reptilia N4BP16
    NEDD4 binding protein 1
    51(a)
    1 ↔ 1
    GL343469.1(619914-637381)
    African clawed frog
    (Xenopus laevis)
    Amphibia n4bp1-pending-prov2 Nedd4 binding protein 1 71.26(n)    BC045006.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi03b052 wufi03b05 75.32(n)   327327  BC059205.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG108896
    --
    22(a)
    1 → many
    3R(15859603-15861777)
    worm
    (Caenorhabditis elegans)
    Secernentea C30F12.16
    Protein C30F12.1 (C30F12.1) mRNA, complete cds
    18(a)
    1 → many
    I(6954411-6961139) WBGene00016260


    ENSEMBL Gene Tree for N4BP1 (if available)
    TreeFam Gene Tree for N4BP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for N4BP1 gene
    NYNRIN2  ZC3H12C2  ZC3H12B2  ZC3H12D2  KHNYN2  ZC3H12A2  

    Find genes that share paralogs with N4BP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for N4BP1 (see all 1416)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1168798881,2
    F--34468460(+) GCATGT/CTGGAG 1 -- int11Minor allele frequency- C:0.02EA 120
    rs1848567891,2
    --34468503(+) AACTTC/TAGGCT 1 -- int10--------
    rs1399649671,2
    --34468517(+) AACCAC/GCTCTT 1 -- int10--------
    rs1453779221,2
    --34468524(+) TCTTCA/GAACTT 1 -- int10--------
    rs1881207031,2
    --34468591(+) ATGTTG/TCAGGC 1 -- int10--------
    rs740179701,2
    C--34468605(+) ACCATC/TGGTGT 1 -- int12Minor allele frequency- T:0.05WA 120
    rs1476735941,2
    --34468628(+) AGTACA/GTGCTC 1 -- int10--------
    rs169462131,2
    C,F,H--34468694(+) AATGTC/GCTAGT 1 -- int18Minor allele frequency- G:0.01NA NS EA WA 674
    rs1116715111,2
    C--34468696(+) TGTCCT/CAGTGG 1 -- int12Minor allele frequency- C:0.13CSA WA 120
    rs745019211,2
    C,F--34468782(+) TGTGGA/TGCCAC 1 -- int12Minor allele frequency- T:0.13CSA WA 120

    HapMap Linkage Disequilibrium report for N4BP1 (48572637 - 48654059 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for N4BP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33450CNV Gain17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing N4BP1
    DNA2.0 Custom Variant and Variant Library Synthesis for N4BP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with N4BP1           About GenesLikeMe

    Genetic Association Database (GAD): N4BP1
    Human Genome Epidemiology (HuGE) Navigator: N4BP1 (1 document)

    Export disorders for N4BP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for N4BP1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with N4BP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    2. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PubMed id 22491018)1, 4 Wang J....Platt A. (Pharmacogenomics J. 2013)
    3. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    4. Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. (PubMed id 11717310)1, 3 Murillas R.... Kuehn M.R. (J. Biol. Chem. 2002)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9683 HGNC: 29850 AceView: N4BP1 Ensembl:ENSG00000102921 euGenes: HUgn9683
    ECgene: N4BP1 H-InvDB: N4BP1

    (According to HUGE)
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    HUGE: KIAA0615

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for N4BP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for N4BP1 gene:
    Search GeneIP for patents involving N4BP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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