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Aliases for N4BP1 Gene

Aliases for N4BP1 Gene

  • NEDD4 Binding Protein 1 2 3 5
  • KIAA0615 4

External Ids for N4BP1 Gene

Previous GeneCards Identifiers for N4BP1 Gene

  • GC16M038991
  • GC16M048624
  • GC16M048311
  • GC16M048354
  • GC16M047131
  • GC16M048572
  • GC16M034461

Summaries for N4BP1 Gene

GeneCards Summary for N4BP1 Gene

N4BP1 (NEDD4 Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is ZC3H12C.

UniProtKB/Swiss-Prot for N4BP1 Gene

  • Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCHs substrates and impairing ubiquitination of substrates (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for N4BP1 Gene

Genomics for N4BP1 Gene

Regulatory Elements for N4BP1 Gene

Enhancers for N4BP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around N4BP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for N4BP1 Gene

48,538,726 bp from pter
48,620,148 bp from pter
81,423 bases
Minus strand

Genomic View for N4BP1 Gene

Genes around N4BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
N4BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for N4BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for N4BP1 Gene

Proteins for N4BP1 Gene

  • Protein details for N4BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NEDD4-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • A7MD49
    • Q2YDX1

    Protein attributes for N4BP1 Gene

    896 amino acids
    Molecular mass:
    100379 Da
    Quaternary structure:
    • Interacts with NEDD4. Interacts with ITCH (via WW domain 2) (By similarity).
    • Sequence=BAA31590.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for N4BP1 Gene

Proteomics data for N4BP1 Gene at MOPED

Post-translational modifications for N4BP1 Gene

  • Monoubiquitinated by NEDD4. Polyubiquitinated, leading to its degradation by the proteasome. Sumoylated with SUMO1, abrogating polyubiquitination and subsequent degradation. Desumoylated by SENP1, leading to accumulation in PML nuclear bodies (By similarity).
  • Ubiquitination at Lys 412, Lys 441, Lys 471, Lys 601, Lys 714, and Lys 773
  • Modification sites at PhosphoSitePlus

Other Protein References for N4BP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for N4BP1 Gene

Domains & Families for N4BP1 Gene

Protein Domains for N4BP1 Gene


Suggested Antigen Peptide Sequences for N4BP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the N4BP1 family.
  • Belongs to the N4BP1 family.
genes like me logo Genes that share domains with N4BP1: view

No data available for Gene Families for N4BP1 Gene

Function for N4BP1 Gene

Molecular function for N4BP1 Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCHs substrates and impairing ubiquitination of substrates (By similarity).
genes like me logo Genes that share phenotypes with N4BP1: view

Animal Models for N4BP1 Gene

MGI Knock Outs for N4BP1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for N4BP1 Gene

Localization for N4BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for N4BP1 Gene

Nucleus, nucleolus. Nucleus, PML body. Note=Primarily localizes to the nucleolus. Also localizes to the PML nuclear bodies, when desumoylated (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for N4BP1 Gene COMPARTMENTS Subcellular localization image for N4BP1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for N4BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016605 PML body IEA,ISS --
genes like me logo Genes that share ontologies with N4BP1: view

Pathways & Interactions for N4BP1 Gene

SuperPathways for N4BP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for N4BP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for N4BP1 Gene

Drugs & Compounds for N4BP1 Gene

No Compound Related Data Available

Transcripts for N4BP1 Gene

Unigene Clusters for N4BP1 Gene

NEDD4 binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for N4BP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2: -

Relevant External Links for N4BP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for N4BP1 Gene

mRNA expression in normal human tissues for N4BP1 Gene

mRNA differential expression in normal tissues according to GTEx for N4BP1 Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for N4BP1 Gene

This gene is overexpressed in Cervix (32.9) and Adrenal (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for N4BP1 Gene

SOURCE GeneReport for Unigene cluster for N4BP1 Gene Hs.511839

mRNA Expression by UniProt/SwissProt for N4BP1 Gene

Tissue specificity: Detected in heart, lung, brain, liver, skeletal muscle, pancreas, kidney, spleen, testis and ovary.
genes like me logo Genes that share expression patterns with N4BP1: view

Protein tissue co-expression partners for N4BP1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for N4BP1 Gene

Orthologs for N4BP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for N4BP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia N4BP1 35
  • 90.33 (n)
  • 89.06 (a)
N4BP1 36
  • 88 (a)
(Canis familiaris)
Mammalia N4BP1 35
  • 90.61 (n)
  • 89.62 (a)
N4BP1 36
  • 90 (a)
(Mus musculus)
Mammalia N4bp1 35
  • 83.17 (n)
  • 81.41 (a)
N4bp1 16
N4bp1 36
  • 81 (a)
(Pan troglodytes)
Mammalia N4BP1 35
  • 99.74 (n)
  • 99.55 (a)
N4BP1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia N4bp1 35
  • 82.92 (n)
  • 81.73 (a)
(Monodelphis domestica)
Mammalia N4BP1 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia N4BP1 36
  • 60 (a)
(Gallus gallus)
Aves N4BP1 35
  • 64.04 (n)
  • 58.58 (a)
N4BP1 36
  • 51 (a)
(Anolis carolinensis)
Reptilia N4BP1 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia n4bp1 35
  • 61.81 (n)
  • 58.74 (a)
Str.18844 35
African clawed frog
(Xenopus laevis)
Amphibia n4bp1-pending-prov 35
(Danio rerio)
Actinopterygii n4bp1 35
  • 52.91 (n)
  • 46.11 (a)
wufi03b05 35
n4bp1 36
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10889 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea C30F12.1 36
  • 18 (a)
Species with no ortholog for N4BP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for N4BP1 Gene

Gene Tree for N4BP1 (if available)
Gene Tree for N4BP1 (if available)

Paralogs for N4BP1 Gene

Paralogs for N4BP1 Gene

genes like me logo Genes that share paralogs with N4BP1: view

Variants for N4BP1 Gene

Sequence variations from dbSNP and Humsavar for N4BP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3859121 -- 48,575,484(+) CATAA(C/T)ATTTC intron-variant
rs3884288 -- 48,584,610(+) AAAAA(-/AA/AAA)CAAAC intron-variant
rs3884289 -- 48,584,795(+) CAATA(-/TATT)NNNGG intron-variant
rs3891865 -- 48,580,794(+) GACTT(C/T)TTTCC intron-variant
rs1224 -- 48,538,906(+) AAAGC(A/G)AGACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for N4BP1 Gene

Variant ID Type Subtype PubMed ID
esv33450 CNV Gain 17666407

Variation tolerance for N4BP1 Gene

Residual Variation Intolerance Score: 7.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.94% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for N4BP1 Gene

Disorders for N4BP1 Gene

Relevant External Links for N4BP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for N4BP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for N4BP1 Gene

Publications for N4BP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. (PMID: 11717310) Murillas R. … Kuehn M.R. (J. Biol. Chem. 2002) 2 3
  3. p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN. (PMID: 24141722) Hong S.W. … Kim T.W. (Cell Death Differ. 2014) 3
  4. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PMID: 22491018) Wang J. … Platt A. (Pharmacogenomics J. 2013) 3
  5. Genome-wide association study of autistic-like traits in a general population study of young adults. (PMID: 24133439) Jones R.M. … Moses E.K. (Front Hum Neurosci 2013) 3

Products for N4BP1 Gene

Sources for N4BP1 Gene