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Aliases for N4BP1 Gene

Aliases for N4BP1 Gene

  • NEDD4 Binding Protein 1 2 3
  • KIAA0615 4

External Ids for N4BP1 Gene

Previous GeneCards Identifiers for N4BP1 Gene

  • GC16M038991
  • GC16M048624
  • GC16M048311
  • GC16M048354
  • GC16M047131
  • GC16M048572
  • GC16M034461

Summaries for N4BP1 Gene

GeneCards Summary for N4BP1 Gene

N4BP1 (NEDD4 Binding Protein 1) is a Protein Coding gene. An important paralog of this gene is ZC3H12C.

UniProtKB/Swiss-Prot for N4BP1 Gene

  • Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCHs substrates and impairing ubiquitination of substrates (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for N4BP1 Gene

Genomics for N4BP1 Gene

Regulatory Elements for N4BP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for N4BP1 Gene

Start:
48,538,726 bp from pter
End:
48,620,148 bp from pter
Size:
81,423 bases
Orientation:
Minus strand

Genomic View for N4BP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for N4BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for N4BP1 Gene

Proteins for N4BP1 Gene

  • Protein details for N4BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75113-N4BP1_HUMAN
    Recommended name:
    NEDD4-binding protein 1
    Protein Accession:
    O75113
    Secondary Accessions:
    • A7MD49
    • Q2YDX1

    Protein attributes for N4BP1 Gene

    Size:
    896 amino acids
    Molecular mass:
    100379 Da
    Quaternary structure:
    • Interacts with NEDD4. Interacts with ITCH (via WW domain 2) (By similarity).
    SequenceCaution:
    • Sequence=BAA31590.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for N4BP1 Gene

Proteomics data for N4BP1 Gene at MOPED

Post-translational modifications for N4BP1 Gene

  • Monoubiquitinated by NEDD4. Polyubiquitinated, leading to its degradation by the proteasome. Sumoylated with SUMO1, abrogating polyubiquitination and subsequent degradation. Desumoylated by SENP1, leading to accumulation in PML nuclear bodies (By similarity).
  • Ubiquitination at Lys297, Lys412, Lys441, Lys471, Lys601, Lys714, and Lys773
  • Modification sites at PhosphoSitePlus

Other Protein References for N4BP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for N4BP1 Gene

Domains for N4BP1 Gene

Protein Domains for N4BP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for N4BP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75113

UniProtKB/Swiss-Prot:

N4BP1_HUMAN :
  • O75113
Family:
  • Belongs to the N4BP1 family.
genes like me logo Genes that share domains with N4BP1: view

No data available for Gene Families for N4BP1 Gene

Function for N4BP1 Gene

Molecular function for N4BP1 Gene

UniProtKB/Swiss-Prot Function: Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCHs substrates and impairing ubiquitination of substrates (By similarity).

Gene Ontology (GO) - Molecular Function for N4BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 21903422
genes like me logo Genes that share ontologies with N4BP1: view

Phenotypes for N4BP1 Gene

MGI mutant phenotypes for N4BP1:
inferred from 1 alleles
GenomeRNAi human phenotypes for N4BP1:
genes like me logo Genes that share phenotypes with N4BP1: view

Animal Models for N4BP1 Gene

MGI Knock Outs for N4BP1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for N4BP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for N4BP1 Gene

Localization for N4BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for N4BP1 Gene

Nucleus, nucleolus. Nucleus, PML body. Note=Primarily localizes to the nucleolus. Also localizes to the PML nuclear bodies, when desumoylated (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for N4BP1 Gene COMPARTMENTS Subcellular localization image for N4BP1 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for N4BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus ISS --
GO:0016605 PML body ISS --
genes like me logo Genes that share ontologies with N4BP1: view

Pathways for N4BP1 Gene

SuperPathways for N4BP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for N4BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031397 negative regulation of protein ubiquitination ISS --
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISS --
GO:0034644 cellular response to UV IMP 17592138
genes like me logo Genes that share ontologies with N4BP1: view

No data available for Pathways by source for N4BP1 Gene

Transcripts for N4BP1 Gene

Unigene Clusters for N4BP1 Gene

NEDD4 binding protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for N4BP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for N4BP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for N4BP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2: -
SP3:

Relevant External Links for N4BP1 Gene

GeneLoc Exon Structure for
N4BP1
ECgene alternative splicing isoforms for
N4BP1

Expression for N4BP1 Gene

mRNA expression in normal human tissues for N4BP1 Gene

mRNA differential expression in normal tissues according to GTEx for N4BP1 Gene

This gene is overexpressed in Whole Blood (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for N4BP1 Gene

SOURCE GeneReport for Unigene cluster for N4BP1 Gene Hs.511839

mRNA Expression by UniProt/SwissProt for N4BP1 Gene

O75113-N4BP1_HUMAN
Tissue specificity: Detected in heart, lung, brain, liver, skeletal muscle, pancreas, kidney, spleen, testis and ovary.
genes like me logo Genes that share expressions with N4BP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for N4BP1 Gene

Orthologs for N4BP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for N4BP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia N4BP1 35
  • 99.74 (n)
  • 99.55 (a)
N4BP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia N4BP1 35
  • 90.33 (n)
  • 89.06 (a)
N4BP1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia N4BP1 35
  • 90.61 (n)
  • 89.62 (a)
N4BP1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia N4bp1 35
  • 83.17 (n)
  • 81.41 (a)
N4bp1 16
N4bp1 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia N4BP1 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia N4BP1 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia N4bp1 35
  • 82.92 (n)
  • 81.73 (a)
chicken
(Gallus gallus)
Aves N4BP1 35
  • 64.04 (n)
  • 58.58 (a)
N4BP1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia N4BP1 36
  • 51 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia n4bp1-pending-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia n4bp1 35
  • 61.81 (n)
  • 58.74 (a)
Str.18844 35
zebrafish
(Danio rerio)
Actinopterygii n4bp1 35
  • 52.91 (n)
  • 46.11 (a)
n4bp1 36
  • 38 (a)
OneToOne
wufi03b05 35
fruit fly
(Drosophila melanogaster)
Insecta CG10889 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C30F12.1 36
  • 18 (a)
OneToMany
Species with no ortholog for N4BP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for N4BP1 Gene

ENSEMBL:
Gene Tree for N4BP1 (if available)
TreeFam:
Gene Tree for N4BP1 (if available)

Paralogs for N4BP1 Gene

Paralogs for N4BP1 Gene

genes like me logo Genes that share paralogs with N4BP1: view

Variants for N4BP1 Gene

Sequence variations from dbSNP and Humsavar for N4BP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1224 -- 48,538,906(+) AAAGC(A/G)AGACA utr-variant-3-prime
rs868792 -- 48,606,721(+) ATTCT(C/T)CTCTA intron-variant
rs871902 -- 48,559,868(-) AAACT(C/T)AGGGC intron-variant
rs871903 -- 48,559,732(-) GGGAA(G/T)TGCCC intron-variant
rs880399 -- 48,542,413(+) TAACT(C/T)CGGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for N4BP1 Gene

Variant ID Type Subtype PubMed ID
esv33450 CNV Gain 17666407

Relevant External Links for N4BP1 Gene

HapMap Linkage Disequilibrium report
N4BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for N4BP1 Gene

Disorders for N4BP1 Gene

Relevant External Links for N4BP1

Genetic Association Database (GAD)
N4BP1
Human Genome Epidemiology (HuGE) Navigator
N4BP1
genes like me logo Genes that share disorders with N4BP1: view

No data available for UniProtKB/Swiss-Prot for N4BP1 Gene

Publications for N4BP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. (PMID: 11717310) Murillas R. … Kuehn M.R. (J. Biol. Chem. 2002) 2 3
  3. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PMID: 19074885) Enjuanes A. … Campo E. (Cancer Res. 2008) 3 48
  4. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PMID: 22491018) Wang J. … Platt A. (Pharmacogenomics J. 2013) 3 48
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for N4BP1 Gene

Sources for N4BP1 Gene

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