 |
 | Services
| |
 |
Aliases & Descriptions for N-PAC
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| BM045 2 | | HIBDL 2, 3 | | NP60 2 |
| | | Descriptions |
|---|
| 3-hydroxyisobutyrate dehydrogenase-like 2 | | 3-hydroxyisobutyrate dehydrogenase-like protein 3 | | Nuclear protein of 60 kDa 3 | | cytokine-like nuclear factor n-pac 2, 3 | | nuclear protein 60 kDa 2 |
|
| | Search outside databases for aliases for N-PAC genePrevious GC identifers: GC16M004879 GC16M004853 |
Summaries for N-PAC(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: NP60_HUMAN, Q49A26Function: Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 |
Genomic Location for N-PAC
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the N-PAC gene 
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 N-PAC Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M004793:
(about GC identifiers)
Start:
|
4,793,205 bp from pter |
End:
|
4,837,294 bp from pter |
Size:
|
44,090 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000016.8 NT_037887.4
| Proteins for N-PAC
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NP60_HUMAN, Q49A26 (See
protein sequence)Recommended Name: Nuclear protein NP60 Size: 553 amino acids; 60547 Da
Subunit: Interacts with MAPK14
Subcellular location: Nucleus
PDB structures from and Proteopedia :2UYY (3D)
 
Secondary accessions: Q5U632 Q6P1Q2 Q6V3W7 Q9BTI1 Q9BXK2Alternative splicing: 4 isoforms: Q49A26-1 Q49A26-2 Q49A26-3 Q49A26-4 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_115958.2
ENSEMBL proteins: ENSP00000322716 ENSP00000371413
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: N-PAC 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for N-PAC: Assays for N-PAC: | Protein
Domains/ Families for N-PAC(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q49A26
ProtoNet protein and cluster: Q49A26 2 Blocks protein families: IPB000313 PWWP domain IPB002204 3-hydroxyisobutyrate dehydrogenase
UniProtKB/Swiss-Prot: NP60_HUMAN, Q49A26Domain: The A.T hook DNA-binding domain is required for the interaction with MAPK14Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family. NP60 subfamilySimilarity: Contains 1 A.T hook DNA-binding domainSimilarity: Contains 1 PWWP domain | Gene Function for N-PAC
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032569
Applied Biosystems Silencer® siRNAs for N-PAC
Sigma-Aldrich siRNA for N-PAC  Sigma-Aldrich shRNA for N-PAC  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032569                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_032569                                  untagged cDNA clones in CMV expression vector (see all 2): NM_032569 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_032569
UniProtKB/Swiss-Prot: NP60_HUMAN, Q49A26Function: Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K65 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for N-PAC
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for N-PAC (ENSP000003227163 Q49A262) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006098 | pentose-phosphate shunt |
IEA | -- | | GO:0008152 | metabolic process |
IEA | -- | About this table
|
Drugs & Compounds for N-PAC(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for N-PAC
|
Transcripts for N-PAC(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032569
Sigma-Aldrich siRNA for N-PAC  Sigma-Aldrich shRNA for N-PAC  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_032569 REFSEQ mRNAs for N-PAC gene: NM_032569.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_032569               OriGene GFP tagged cDNA clone in CMV expression vector: NM_032569                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_032569                                  untagged cDNA clones in CMV expression vector (see all 2): NM_032569  Additional cDNA sequence: AF217521.1 AF244907.1 AF326966.1 AK096730.1 AK296842.1 AK307834.1 AY352585.1 BC003693.1 BC022809.1 BC032855.1 BC047223.1 BC048291.1 BC063039.1 BC064940.1 BC071698.1 BC073868.1 CR623197.1 CR933687.1 19 DOTS entries: DT.97820255 DT.455865 DT.97781123 DT.120704602 DT.40107533 DT.97854573 DT.97854571 DT.99936178 DT.95335108 DT.92424029 DT.91741097 DT.91881931 DT.100798579 DT.100798583 DT.91875664 DT.91884444 DT.92424028 DT.95202224 DT.95326206 24/521 AceView cDNA sequences (see all 521
):CR603174 AA346657 BQ941437 AI299980 CB139232 BM703709 CF127496 AI276588 BM931710 AI336225 CK725160 AI401496 BE250606 AW272381 CB529066 BU158924 BM728680 BM503391 CF135011 CR618679 BE503523 BU855659 CR616895 AW292633
highest scoring ESTs for N-PAC:AF244907 AF326966 AI671768 AL702600 AY352585 BC032855 BC064940 BI767890 BM808810 BM808969 Unigene Cluster for N-PAC: Cytokine-like nuclear factor n-pac Hs.387255 [show with all ESTs]Unigene Representative Sequence: NM_032569
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for N-PAC (see all 8
)
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | |
| SP1: | |   | |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | - |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
2 Ensembl transcripts including schematic representations: ENST00000321919
ENST00000381983
|
Expression for N-PAC
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| N-PAC expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for N-PAC
1 / 2 / 3 14 probe-sets matching N-PAC gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ATTTTGTGCA
SOURCE GeneReport for Unigene cluster: Hs.387255
|
Orthologs for N-PAC
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for N-PAC gene from 5/12 species (see all 12
)
About this table Species with no ortholog for N-PAC
ENSEMBL Gene Tree for N-PAC | Paralogs for N-PAC(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for N-PAC gene
- HIBADH2
|
SNPs/Variants for N-PAC(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for N-PAC (up to first 250kb)
|
Disorders & Mutations for N-PAC
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 610660
|
Medical News for N-PAC(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications for N-PAC (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 6 PubMed articles for N-PAC gene: |
Search for N-PAC
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing N-PAC
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing N-PAC
(According to HUGE)
About This Section
| -- |
Specialized Databases showing N-PAC(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for N-PAC(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for N-PAC:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for N-PAC |
|
 |
 | | | |
GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009
|