 |
 | Services
|
 |
 |
Aliases &
Descriptions
for MTNR1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
User Feedback | | Aliases & Descriptions |
|---|
| melatonin receptor 1B1 2 | | MEL-1B-R2 | | Mel1b receptor2 3 | | MT22 | | FGQTL22 | | melatonin receptor type 1B2 | | melatonin receptor MEL1B2 | | Mel-1B-R3 |
Search outside databases for aliases for MTNR1B genePrevious GC identifers: GC11P095033 GC11P094210 GC11P092887 GC11P092390 GC11P092342 |
Summaries
for MTNR1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
User Feedback | Entrez Gene summary for MTNR1B:
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by thepineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor.It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate inlight-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. (provided byRefSeq)
UniProtKB/Swiss-Prot: MTR1B_HUMAN, P49286Function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin.The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclaseactivity
 summary
for MTNR1B:Melatonin receptors are a group of high affinity Gi/Go protein-coupled receptors, which are split into two
subtypes; MT1 and MT2. A third melatonin receptor, MT3, was proposed to exist but it has since been shown to
be the hamster homolog of human quinone reductase 2 and is therefore not considered within this GPCR
classification. MT1 and MT2 receptors are widely distributed with high concentrations found in the brain
(especially in the suprachiasmatic nucleus) and in the retina. Lower expression levels are seen in the
kidney, heart, lung and liver. Melatonin receptors regulate a variety of physiological and neuroendrocrine
functions including control of the endogenous circadian rhythm, thermoregulation and prolactin expression.
The human genes encoding MT1 and MT2 receptors are located on chromosome 4q35.1 and chromosome 11q21-22
respectively.
Gene Wiki entry for MTNR1B (Melatonin receptor 1B) |
Genomic Views
for MTNR1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl (release 56),
Regulatory elements and Epigenetics data according to
SABiosciences)
About This Section
User Feedback | Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MTNR1B gene upstream (promoter) region  :
AREB6 c-Myb LCR-F1 NF-1 MIF-1 Pbx1a POU2F1
Epigenetics:
Search SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for MTNR1B 
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q21-q22 Ensembl cytogenetic band: 11q14.3 HGNC cytogenetic band: 11q21-q22MTNR1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P092705: view genomic region
(about GC identifiers)
Start:
|
92,702,789 bp from pter |
End:
|
92,715,948 bp from pter |
Size:
|
13,160 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000011.9 NT_167190.1
| Proteins
for MTNR1B gene
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene,
Novus Biologicals, and/or
Sino Biological,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 May 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abnova,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
User Feedback | UniProtKB/Swiss-Prot: MTR1B_HUMAN, P49286 (See
protein sequence)Recommended Name: Melatonin receptor type 1B Size: 362 amino acids; 40188 Da
Subcellular location: Cell membrane; Multi-pass membrane proteinREFSEQ proteins: NP_005950.1
ENSEMBL proteins: ENSP00000257068
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
MTNR1B for ontologies About GeneDecksing
Antibodies for MTNR1B:
Assays for MTNR1B: | Protein
Domains/
Families
for MTNR1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
User Feedback |
MTNR1B for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P49286ProtoNet protein and cluster: P49286 1 Blocks protein family: IPB000025 Melatonin receptor signature
UniProtKB/Swiss-Prot: MTR1B_HUMAN, P49286Similarity: Belongs to the G-protein coupled receptor 1 family | Gene Function
for MTNR1B gene
(According to MGI May 08 2010, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Millipore,
Abnova,
siRNAs from
Applied Biosystems,
Sigma-Aldrich, Clones from
Millipore,
Sigma-Aldrich,
OriGene,
Sino Biological,
Ontologies according to Gene Ontology Consortium 01 May 2010 via
Entrez Gene.)
About This Section
User Feedback | UniProtKB/Swiss-Prot: MTR1B_HUMAN, P49286Function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin.The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclaseactivityGenatlas biochemistry entry for MTNR1B:melatonin receptor 1B,expressed in retina and brain,G protein coupled receptor superfamily 3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
MTNR1B for ontologies About GeneDecksing
Animal Models: 1 MGI mutant phenotype (inferred from 3 alleles ) (MGI details for Mtnr1b):
MTNR1B for phenotypes About GeneDecksing
| Pathways & Interactions
for MTNR1B gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
Applied Biosystems GeneAssist,
KEGG
and/or UniProtKB,
(map by GeneGo),
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 May 2010 via
Entrez Gene).
About This Section
User Feedback |
MTNR1B for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" Pathway for MTNR1B (Your Favorite Gene powered by Ingenuity)
1  GeneAssist Pathway for MTNR1B
1  Kegg Pathway (Kegg details for MTNR1B):  | hsa04080 Neuroactive ligand-receptor interaction |
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MTNR1B
2 Interacting proteins for MTNR1B (ENSP000002570683) via UniProtKB, MINT, and/or STRING About this table
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
IEA | -- | | GO:0007186 | G-protein coupled receptor protein signaling pathway |
-- | -- | | GO:0007187 | G-protein signaling, coupled to cyclic nucleotide second messenger |
TAS | 7568007 | | GO:0007268 | synaptic transmission |
TAS | 7568007 |
About this table
MTNR1B for ontologies About GeneDecksing
|
Drugs & Compounds
for MTNR1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
User Feedback |
MTNR1B for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for MTNR1B |
Compounds for MTNR1B available from Tocris Bioscience
About this table
10/25  Novoseek chemical compound relationships for MTNR1B gene (see all 25
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| melatonin |
100.00 |
170 |
9089668 (6), 7568007 (5), 18621029 (3), 17632395 (3) (see all 100) |
| luzindole |
22.98 |
8 |
16098095 (3), 9737724 (1), 18664376 (1), 14962061 (1) (see all 6) |
| ramelteon |
22.12 |
8 |
18664376 (4), 18728808 (1), 18368944 (1), 17389558 (1) (see all 5) |
| 2-iodomelatonin |
8.62 |
3 |
12697285 (1), 11948236 (1), 11812653 (1) |
| quinone |
4.74 |
4 |
19449447 (1), 19409957 (1), 16293234 (1), 12628439 (1) |
| 2[125i]iodomelatonin |
4.31 |
2 |
9618428 (1), 19340560 (1) |
| ammtc |
3.86 |
1 |
11888668 (1) |
| gr196429 |
3.78 |
1 |
9618428 (1) |
| iik7 |
3.68 |
1 |
19429170 (1) |
| arylalkylamine |
2.22 |
1 |
16150106 (1) |
About this table
|
Transcripts
for MTNR1B gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Primers from
OriGene and/or
SABiosciences,
Expression Assays from Applied Biosystems)
About This Section
User Feedback | Assays:  Applied Biosystems TaqMan® Gene Expression Assays: NM_005959
| Clones: |  | Origene GFP tagged cDNA clones in CMV expression vector: MTNR1B
Origene Myc/DDK tagged cDNA clones in CMV expression vector: MTNR1B
Origene untagged cDNA clones in CMV expression vector: MTNR1B
|
| Primers: | | Origene genome-wide validated SYBR primer pairs: MTNR1B
| | | SABiosciences RT2 qPCR Primer Assay for MTNR1B: PPH02671A |
REFSEQ mRNAs for MTNR1B gene: NM_005959.3 Additional cDNA sequence: AF467654.1 AY114100.1 AY521019.1 BC069163.1 U25341.1 2 DOTS entries: DT.102821914 DT.101963086 12 AceView cDNA sequences: U25341 AI222420 BC069163 CN842566 AY521019 NM_005959 BF725791 BV169750 CN842471 CN835231 CN835266 BX118886
 highest scoring ESTs for MTNR1B:U25341 AF467654 AY521019 BC069163 CN842471 CN842566 CN835231 CN835266 NM_005959 AI222420 Unigene Cluster for MTNR1B: Melatonin receptor 1B Hs.569039 [show with all ESTs]Unigene Representative Sequence: NM_005959
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000257068
|
Expression
for MTNR1B gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 223 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems,
Primers from
OriGene and/or
SABiosciences
)
About This Section
User Feedback | MTNR1B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for MTNR1B
1 / 2 / 3 3 probe-sets matching MTNR1B gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 31405_at2, 3
|
U95-A |
1 |
0.62 |
1.00 |
1.00 |
1.00 |
U25341 |
1.00 |
1.00 |
1.00 |
1 |
| 208516_at2, 3
|
U133-A |
1 |
0.73 |
1.00 |
-- |
-- |
NM_005959 |
0.60 |
1.00 |
0.82 |
1 |
| 208516_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
MTNR1B for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.569039
Expression variation in blood from EXPOLDB for MTNR1B UniProtKB/Swiss-Prot: MTR1B_HUMAN, P49286Tissue specificity: Expressed in retina and less in brain and hippocampus
| Primers: | | Origene genome-wide validated SYBR primer pairs: MTNR1B 
| | | SABiosciences RT2 qPCR Primer Assay for MTNR1B: PPH02671A |
|
Orthologs
for MTNR1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI May 08 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
User Feedback |
Orthologs for MTNR1B gene from 5/7 species (see all 7
)
About this table Species with no ortholog for MTNR1B
ENSEMBL Gene Tree for MTNR1B | Paralogs
for MTNR1B gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
User Feedback | Paralogs for MTNR1B gene
- MTNR1A2 GPR502
MTNR1B for paralogs About GeneDecksing
|
Genomic Variants
for MTNR1B gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants,
Genotyping Reagents from
Applied Biosystems)
About This Section
User Feedback |
The following additional 41 SNP(s) have been
found in Applied Biosystems data source:
(Click
for
Applied Biosystems TaqMan ® Genotyping Assay)
HapMap Linkage Disequilibrium images for MTNR1B (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for MTNR1B
3 CNVs: 75754 37670 66034
1 Indel: 85931 |
Disorders & Mutations
for MTNR1B gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
User Feedback |
MTNR1B for disorders About GeneDecksing
OMIM: 600804
10/24 Novoseek disease relationships for MTNR1B gene (see all 24
)
About this table
Human Gene Mutation Database: MTNR1B
Genetic Association Database: MTNR1B
Human Genome Epidemiology Navigator: MTNR1B (28 documents)
|
Medical News
for MTNR1B gene(Possibly Related Articles in
Doctor's Guide)
About This Section
User Feedback | -- |
Publications
for MTNR1B gene (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
User Feedback | 10/95 PubMed articles for MTNR1B gene (see all 95
):- Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. (PubMed id 7568007)1, 3, 4 Reppert S.M....Gusella J.F. (1995)
- Positive relationship between melatonin receptor type 1B polymorphism and rheumatoid factor in rheumatoid arthritis patients in the Korean population. (PubMed id 16098099)1, 3, 6 Ha E....Hong S.J. (2005)
- Genetic polymorphisms of human melatonin 1b receptor gene in circadian rhythm sleep disorders and controls. (PubMed id 10696804)1, 3, 4 Ebisawa T.... Yamauchi T. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis. (PubMed id 17632395)1, 3 Qiu X.S....Cheng J.C. (2007)
- The role of melatonin receptor 1B gene (MTNR1B) in adolescent idiopathic scoliosis--a genetic association study. (PubMed id 17108395)1, 3 Qiu X.S....Cheng J.C. (2006)
- Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. (PubMed id 19060908)1, 3 Lyssenko V....Groop L. (2009)
- Combined effects of single-nucleotide polymorphisms i n GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes ris k. (PubMed id 19533084)1, 3 Reiling E....'t Hart L.M. (2009)
- The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease. (PubMed id 17316165)1, 3 Savaskan E....Meyer P. (2007)
- A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. (PubMed id 19060909)1, 3 Bouatia-Naji N....Froguel P. (2009)
|
Search for MTNR1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
User Feedback |
|
Genome Databases showing MTNR1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
User Feedback |
| Other Databases showing MTNR1B gene
(According to HUGE)
About This Section
User Feedback | -- |
Specialized Databases showing MTNR1B gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
User Feedback |
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/Melatonin_receptor |
|
| | | About This Section
User Feedback | Patent Information for MTNR1B gene:
Search GeneIP for patents involving MTNR1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
| Services
for MTNR1B gene(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Novus Biologicals,
Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
User Feedback | 
Products for MTNR1B:
|
User Feedback
|
