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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MZT2B Gene

protein-coding   GIFtS: 46
GCID: GC02P130941

Mitotic Spindle Organizing Protein 2B

(Previous names: family with sequence similarity 128, member B)
(Previous symbol: FAM128B)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitotic Spindle Organizing Protein 2B1 2
FAM128B1 2 3 5
Mitotic-Spindle Organizing Protein Associated With A Ring Of Gamma-Tubulin
2B1 2 3
MOZART2B2 3 5
Family With Sequence Similarity 128, Member B1 2
Mitotic-Spindle Organizing Protein 2B2

External Ids:    HGNC: 258861   Entrez Gene: 800972   Ensembl: ENSG000001520827   OMIM: 6134505   UniProtKB: Q6NZ673   

Export aliases for MZT2B gene to outside databases

Previous GC identifer: GC02P123235


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MZT2B Gene: 
MZT2B (mitotic spindle organizing protein 2B) is a protein-coding gene. Diseases associated with MZT2B include microcephaly. GO annotations related to this gene include protein binding. An important paralog of this gene is MZT2A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022135.16  NC_018913.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MZT2B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMZT2B promoter sequence
   Search SABiosciences Chromatin IP Primers for MZT2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MZT2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1   Ensembl cytogenetic band:  2q21.1   HGNC cytogenetic band: 2q21.1

MZT2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MZT2B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P130941:  view genomic region     (about GC identifiers)

Start:
130,939,310 bp from pter      End:
130,948,302 bp from pter
Size:
8,993 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MZT2B_HUMAN, Q6NZ67 (See protein sequence)
Recommended Name: Mitotic-spindle organizing protein 2B  
Size: 158 amino acids; 16226 Da
Subunit: Part of the gamma-tubulin complex. Interacts with TUBG1
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton,
spindle
Secondary accessions: Q96CG4

Explore the universe of human proteins at neXtProt for MZT2B: NX_Q6NZ67

Explore proteomics data for MZT2B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6NZ67

  • MZT2B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MZT2B Protein Expression
    REFSEQ proteins: NP_079305.2  
    ENSEMBL proteins: 
     ENSP00000398749   ENSP00000387805   ENSP00000281871   ENSP00000386419   ENSP00000404629  

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    Cloud-Clone Corp. Proteins for MZT2B 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA--
    GO:0005819spindle IDA--
    GO:0008274gamma-tubulin ring complex IDA--

    MZT2B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR024332 MOZART2

    Graphical View of Domain Structure for InterPro Entry Q6NZ67

    ProtoNet protein and cluster: Q6NZ67

    UniProtKB/Swiss-Prot: MZT2B_HUMAN, Q6NZ67
    Similarity: Belongs to the MOZART2 family


    MZT2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    MZT2B for ontologies           About GeneDecksing


    Animal Models:
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MZT2B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MZT2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/17 Interacting proteins for MZT2B (Q6NZ671, 2, 3 ENSP000002818714) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SETDB1Q150472, 3, ENSP000003579654MINT-8270264 I2D: score=2 STRING: ENSP00000357965
    CDC37Q165432, 3MINT-8250866 I2D: score=2 
    TUBG1P232581, 3, ENSP000002514134EBI-1052566,EBI-302589 I2D: score=1 STRING: ENSP00000251413
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    TUBGCP2Q9BSJ23, ENSP000002529364I2D: score=1 STRING: ENSP00000252936
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MZT2B

    Search CenterWatch for drugs/clinical trials and news about MZT2B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MZT2B gene: 
    NM_025029.3  

    Unigene Cluster for MZT2B:

    Mitotic spindle organizing protein 2B
    Hs.469925  [show with all ESTs]
    Unigene Representative Sequence: BI758897
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425361 ENST00000457492 ENST00000281871(uc002tqu.3) ENST00000409255
    ENST00000455239 ENST00000485869 ENST00000480182 ENST00000491178
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MZT2B
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    Additional mRNA sequence: 

    BC014255.2 BC066296.1 

    24/25 DOTS entries (see all 25):

    DT.95357791  DT.100040544  DT.95288728  DT.95287225  DT.40285940  DT.92470739  DT.91882168  DT.40234559 
    DT.120981153  DT.100828524  DT.120980873  DT.120980939  DT.95357792  DT.100040442  DT.100691549  DT.435893 
    DT.91644653  DT.92470725  DT.95148741  DT.95148742  DT.95203704  DT.95253479  DT.100687923  DT.100800109 

    24/210 AceView cDNA sequences (see all 210):

    BQ057792 AL046700 CA389232 AI494321 AI218442 BQ879474 F36716 AI138643 
    BQ687799 BI792804 BE875101 AI188256 BU607442 AI540181 BI793053 CD673427 
    AJ572218 AI658859 BI793071 CR624733 BC014255 BI792819 AI498751 BQ893573 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MZT2B expression in normal human tissues (normalized intensities)      MZT2B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MZT2B Expression
    About this image


    MZT2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus

    See MZT2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MZT2B

    SOURCE GeneReport for Unigene cluster: Hs.469925
        SABiosciences Custom PCR Arrays for MZT2B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MZT2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MZT2B gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mzt21 , 5 mitotic spindle organizing protein 21, 5 74.84(n)1
    72.26(a)1
      16 (10.09 cM)5
    720831  NM_029354.21  NP_083630.11 
     158484415 
    chicken
    (Gallus gallus)
    Aves MZT2B1 mitotic spindle organizing protein 2B 74.92(n)
    67.89(a)
      768838  XM_001231984.2  XP_001231985.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    50(a)
    43(a)
    many ↔ many
    many ↔ many
    GL343782.1(77329-90479)
    GL343669.1(98159-98380)
    zebrafish
    (Danio rerio)
    Actinopterygii mzt2b1 mitotic spindle organizing protein 2B 59.94(n)
    59.65(a)
      445174  NM_001003568.1  NP_001003568.1 


    ENSEMBL Gene Tree for MZT2B (if available)
    TreeFam Gene Tree for MZT2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MZT2B gene
    MZT2A2  
    1 SIMAP similar gene for MZT2B using alignment to 5 protein entries:     MZT2B_HUMAN (see all proteins):
    MZT2A

    MZT2B for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MZT2B
    PGOHUM00000248508 PGOHUM00000246254


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/383 SNPs in MZT2B are shown (see all 383)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1910808571,2
    --123233274(+) GATCCA/GCTGCC 1 -- us2k10--------
    rs1807522201,2
    --123233368(+) ATCTCA/GGCTCA 1 -- us2k10--------
    rs1431055821,2
    C--123233454(+) CCACCA/CCATCC 1 -- us2k10--------
    rs1807596301,2
    --123239489(+) CAGACA/GAGGAA 1 -- int10--------
    rs2021699651,2
    --123239573(+) GTGAC-/ATGTGAT 1 -- int10--------
    rs1398963821,2
    --123239793(+) TCAAGA/GGTCAT 1 -- int10--------
    rs1864482081,2
    --123239915(+) GAACTC/GGGTAA 1 -- int10--------
    rs1492976871,2
    --123239916(+) AACTCA/GGTAAT 1 -- int10--------
    rs1910007881,2
    --123239918(+) CTCGGG/TAATAA 1 -- int10--------
    rs2005466601,2
    --123239926(+) TAACA-/TGACCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for MZT2B (130939310 - 130948302 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/25 variations for MZT2B (see all 25):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834375CNV Loss17160897
    nsv459274CNV Loss19166990
    nsv428403CNV Loss18775914
    nsv821629CNV Loss15273396
    dgv4306n71CNV Gain21882294
    dgv475n27CNV Gain19166990
    nsv875061CNV Gain21882294
    nsv482053CNV Gain20164927
    nsv818080CNV Gain17921354
    nsv875087CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613450    OMIM disorders: --

    2 diseases for MZT2B:    About MalaCards
    microcephaly    

    1 disease from the University of Copenhagen DISEASES database for MZT2B:
    Microcephaly

    MZT2B for disorders           About GeneDecksing

    Genetic Association Database (GAD): MZT2B
    Human Genome Epidemiology (HuGE) Navigator: MZT2B (3 documents)

    Export disorders for MZT2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MZT2B gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with MZT2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1, 2, 3 Hutchins J.R....Peters J.M. (2010)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    9. Proteomic profiling of Myc-associated proteins. (PubMed id 21150319)1 Agrawal P....Sedivy J.M. (2010)
    10. CDK5RAP2 stimulates microtubule nucleation by the gamm a-tubulin ring complex. (PubMed id 21135143)1 Choi Y.K....Qi R.Z. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80097 HGNC: 25886 AceView: FLJ14346 Ensembl:ENSG00000152082 euGenes: HUgn80097
    ECgene: MZT2B H-InvDB: MZT2B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MZT2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MZT2B gene:
    Search GeneIP for patents involving MZT2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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