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Aliases for MZT2B Gene

Aliases for MZT2B Gene

  • Mitotic Spindle Organizing Protein 2B 2 3 5
  • Mitotic-Spindle Organizing Protein Associated With A Ring Of Gamma-Tubulin 2B 2 3 4
  • Family With Sequence Similarity 128, Member B 2 3
  • MOZART2B 3 4
  • FAM128B 3 4
  • Mitotic-Spindle Organizing Protein 2B 3

External Ids for MZT2B Gene

Previous HGNC Symbols for MZT2B Gene

  • FAM128B

Previous GeneCards Identifiers for MZT2B Gene

  • GC02P130941
  • GC02P123235

Summaries for MZT2B Gene

GeneCards Summary for MZT2B Gene

MZT2B (Mitotic Spindle Organizing Protein 2B) is a Protein Coding gene. An important paralog of this gene is MIR4784.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MZT2B Gene

Genomics for MZT2B Gene

Regulatory Elements for MZT2B Gene

Enhancers for MZT2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MZT2B on UCSC Golden Path with GeneCards custom track

Promoters for MZT2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MZT2B Gene

130,181,544 bp from pter
130,204,794 bp from pter
23,251 bases
Plus strand

Genomic View for MZT2B Gene

Genes around MZT2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MZT2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MZT2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MZT2B Gene

Proteins for MZT2B Gene

  • Protein details for MZT2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitotic-spindle organizing protein 2B
    Protein Accession:
    Secondary Accessions:
    • Q96CG4

    Protein attributes for MZT2B Gene

    158 amino acids
    Molecular mass:
    16226 Da
    Quaternary structure:
    • Part of the gamma-tubulin complex. Interacts with TUBG1.

neXtProt entry for MZT2B Gene

Post-translational modifications for MZT2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MZT2B Gene

No data available for DME Specific Peptides for MZT2B Gene

Domains & Families for MZT2B Gene

Protein Domains for MZT2B Gene


Suggested Antigen Peptide Sequences for MZT2B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MOZART2 family.
  • Belongs to the MOZART2 family.
genes like me logo Genes that share domains with MZT2B: view

No data available for Gene Families for MZT2B Gene

Function for MZT2B Gene

Gene Ontology (GO) - Molecular Function for MZT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20360068
genes like me logo Genes that share ontologies with MZT2B: view

Phenotypes for MZT2B Gene

genes like me logo Genes that share phenotypes with MZT2B: view

Animal Model Products

CRISPR Products

miRNA for MZT2B Gene

miRTarBase miRNAs that target MZT2B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MZT2B Gene

Localization for MZT2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MZT2B Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

Jensen Localization Image for MZT2B Gene COMPARTMENTS Subcellular localization image for MZT2B gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for MZT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 20360068
GO:0005819 spindle IDA 20360068
GO:0008274 gamma-tubulin ring complex IDA 20360068
genes like me logo Genes that share ontologies with MZT2B: view

Pathways & Interactions for MZT2B Gene

SuperPathways for MZT2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MZT2B Gene


No data available for Pathways by source and SIGNOR curated interactions for MZT2B Gene

Drugs & Compounds for MZT2B Gene

No Compound Related Data Available

Transcripts for MZT2B Gene

Unigene Clusters for MZT2B Gene

Mitotic spindle organizing protein 2B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MZT2B Gene

No ASD Table

Relevant External Links for MZT2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MZT2B Gene

mRNA expression in normal human tissues for MZT2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MZT2B Gene

This gene is overexpressed in Bone (40.0) and Pancreas (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MZT2B Gene

Protein tissue co-expression partners for MZT2B Gene

NURSA nuclear receptor signaling pathways regulating expression of MZT2B Gene:


SOURCE GeneReport for Unigene cluster for MZT2B Gene:

genes like me logo Genes that share expression patterns with MZT2B: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MZT2B Gene

Orthologs for MZT2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MZT2B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC787548 34
  • 87.47 (n)
  • 82.27 (a)
MZT2 35
  • 82 (a)
(Canis familiaris)
Mammalia MZT2B 34
  • 91.02 (n)
  • 94.33 (a)
-- 35
  • 94 (a)
(Pan troglodytes)
Mammalia MZT2B 34
  • 99.16 (n)
  • 99.37 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 69 (a)
(Mus musculus)
Mammalia Mzt2 35
  • 70 (a)
(Gallus gallus)
Aves -- 35
  • 54 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 41 (a)
-- 35
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mzt2b 34
  • 60.43 (n)
  • 56.13 (a)
(Danio rerio)
Actinopterygii mzt2b 34
  • 59.06 (n)
  • 57.89 (a)
mzt2b 35
  • 35 (a)
Species where no ortholog for MZT2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MZT2B Gene

Gene Tree for MZT2B (if available)
Gene Tree for MZT2B (if available)

Paralogs for MZT2B Gene

Paralogs for MZT2B Gene

(1) SIMAP similar genes for MZT2B Gene using alignment to 5 proteins: Pseudogenes for MZT2B Gene

genes like me logo Genes that share paralogs with MZT2B: view

Variants for MZT2B Gene

Sequence variations from dbSNP and Humsavar for MZT2B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1043059 - 130,190,502(+) GGGAG(C/T)ATTGG intron-variant, downstream-variant-500B, reference, synonymous-codon, missense
rs1043152 - 130,190,613(+) TACAC(A/G)GGGCA intron-variant, downstream-variant-500B, reference, synonymous-codon, missense
rs1043073 -- 130,190,529(+) CAGCC(A/G/T)CGAAG intron-variant, downstream-variant-500B, reference, synonymous-codon, missense
rs1043167 -- 130,190,645(+) CTTGT(C/T)GCATC intron-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs1043173 -- 130,190,646(+) TTGTT(A/G)CATCT intron-variant, downstream-variant-500B, reference, synonymous-codon, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MZT2B Gene

Variant ID Type Subtype PubMed ID
dgv2032n106 OTHER inversion 24896259
dgv4073n100 CNV gain 25217958
dgv475n27 CNV gain 19166990
dgv7079n54 CNV loss 21841781
dgv7080n54 CNV gain 21841781
esv2751826 CNV gain 17911159
esv2759092 CNV gain+loss 17122850
esv2760631 CNV gain+loss 21179565
esv2763387 CNV loss 21179565
esv3584065 CNV loss 25503493
esv3592440 CNV loss 21293372
esv3592441 CNV gain 21293372
esv3893326 CNV gain 25118596
nsv1001337 CNV loss 25217958
nsv1004301 CNV loss 25217958
nsv1005664 CNV loss 25217958
nsv1008911 CNV gain 25217958
nsv1008970 CNV loss 25217958
nsv1072028 CNV deletion 25765185
nsv428403 CNV loss 18775914
nsv459274 CNV loss 19166990
nsv470485 CNV gain 18288195
nsv482053 CNV gain 20164927
nsv520559 CNV gain+loss 19592680
nsv583046 CNV loss 21841781
nsv583113 CNV gain 21841781
nsv7327 OTHER inversion 18451855
nsv818080 CNV gain 17921354
nsv821629 CNV loss 15273396
nsv834375 CNV loss 17160897
nsv961882 CNV duplication 23825009
nsv998333 CNV gain+loss 25217958

Variation tolerance for MZT2B Gene

Gene Damage Index Score: 1.97; 36.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MZT2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MZT2B Gene

Disorders for MZT2B Gene

Relevant External Links for MZT2B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MZT2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MZT2B Gene

Publications for MZT2B Gene

  1. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 2 3 4 65
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  3. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 65

Products for MZT2B Gene

Sources for MZT2B Gene

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