MZT2B Gene
protein-coding GIFtS: 44
GCID: GC02P130941
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mitotic spindle organizing protein 2B(Previous names: family with sequence similarity 128, member B )
(Previous symbol: FAM128B)
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Aliases
for MZT2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitotic Spindle Organizing Protein 2B1 2 | | Mitotic-Spindle Organizing Protein Associated With A Ring Of Gamma-Tubulin 2B2 3 | | FAM128B1 2 3 5 | | FLJ143461 | | MOZART2B1 2 3 5 | | Mitotic-Spindle Organizing Protein 2B2 | | Family With Sequence Similarity 128, Member B1 2 | | |
Export aliases for MZT2B gene to outside databasesPrevious GC identifer: GC02P123235 |
Summaries
for MZT2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MZT2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MZT2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for MZT2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MZT2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q21.1 Ensembl cytogenetic band: 2q21.1 HGNC cytogenetic band: 2q21.1MZT2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P130941: view genomic region
(about GC identifiers)
Start:
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130,939,310 bp from pter |
End:
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130,948,302 bp from pter |
Size:
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8,993 bases |
Orientation:
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plus strand |
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Proteins
for MZT2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MZT2B_HUMAN, Q6NZ67 (See
protein sequence)Recommended Name: Mitotic-spindle organizing protein 2B Size: 158 amino acids; 16226 Da
Subunit: Part of the gamma-tubulin complex. Interacts with TUBG1
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle
Secondary accessions: Q96CG4Explore the universe of human proteins at neXtProt for MZT2B: NX_Q6NZ67
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6NZ67
MZT2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079305.2
ENSEMBL proteins: ENSP00000398749 ENSP00000387805 ENSP00000281871 ENSP00000386419 ENSP00000404629
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MZT2B for ontologies About GeneDecksing
MZT2B Antibody Products:
Assay Products for MZT2B: |
Protein
Domains /
Families
for MZT2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MZT2B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6NZ67ProtoNet protein and cluster: Q6NZ67 UniProtKB/Swiss-Prot: MZT2B_HUMAN, Q6NZ67Similarity: Belongs to the MOZART2 family |
Function
for MZT2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MZT2B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MZT2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MZT2B (NM_025029) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MZT2B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MZT2B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
MZT2B for ontologies About GeneDecksing
|
Pathways & Interactions
for MZT2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MZT2B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/17 Interacting proteins for MZT2B (Q6NZ671, 2, 3 ENSP000002818714) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
|
Drugs & Compounds
for MZT2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MZT2B
Search CenterWatch for drugs/clinical trials and news about MZT2B
|
Transcripts
for MZT2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MZT2B gene: NM_025029.3 Unigene Cluster for MZT2B: Mitotic spindle organizing protein 2B Hs.469925 [show with all ESTs]Unigene Representative Sequence: BQ6766898 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000425361 ENST00000457492 ENST00000281871(uc002tqu.3) ENST00000409255
ENST00000455239 ENST00000485869 ENST00000480182 ENST00000491178
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MZT2B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MZT2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MZT2B (NM_025029) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MZT2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MZT2B |
Additional cDNA sequence: BC014255.2 BC066296.1 24/25 DOTS entries (see all 25): DT.95357791 DT.100040544 DT.95288728 DT.95287225 DT.40285940 DT.92470739 DT.91882168 DT.40234559 DT.100828524 DT.120981153 DT.120980873 DT.120980939 DT.95357792 DT.100040442 DT.100691549 DT.435893 DT.91644653 DT.92470725 DT.95148741 DT.95148742 DT.95253479 DT.100687923 DT.100800109 DT.95203704 24/210 AceView cDNA sequences (see all 210): AI658859 CK820989 BI793053 BE875101 BM785240 BQ687799 CR624733 AL046700 BI792804 AI540181 BQ879474 BQ057792 F36716 BI793071 CD673427 AI498751 CR623609 BU607442 BM909862 BC014255 AJ572218 BI792819 AI494321 AI138643
GeneLoc Exon Structure
|
Expression
for MZT2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MZT2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MZT2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MZT2B
SOURCE GeneReport for Unigene cluster: Hs.469925
SABiosciences Custom PCR Arrays for MZT2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MZT2B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MZT2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MZT2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MZT2B |
Orthologs
for MZT2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MZT2B gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for MZT2B (if available)
TreeFam Gene Tree for MZT2B (if available) |
Paralogs
for MZT2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MZT2B gene
- MZT2A2
1 SIMAP similar gene for MZT2B using alignment to 5 protein entries: MZT2B_HUMAN (see all proteins):MZT2A
MZT2B for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for MZT2B
PGOHUM00000248508 PGOHUM00000246254
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Genomic Variants
for MZT2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MZT2B (130939310 - 130948302 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MZT2B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MZT2B |
|
Disorders
/ Diseases
for MZT2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MZT2B for disorders About GeneDecksing
OMIM gene information: 613450
OMIM disorders: --
1  disease for MZT2B: About MalaCardsmicrocephaly
1 disease from the University of Copenhagen DISEASES database for MZT2B:Microcephaly Human Genome Epidemiology (HuGE) Navigator: MZT2B (3 documents)
Export disorders for MZT2B gene to outside databases
|
Publications
for MZT2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MZT2B gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with MZT2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1, 2, 3 Hutchins J.R....Peters J.M. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- CDK5RAP2 stimulates microtubule nucleation by the gamm a-tubulin ring complex. (PubMed id 21135143)1 Choi Y.K....Qi R.Z. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
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External Searches for MZT2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MZT2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MZT2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MZT2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MZT2B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MZT2B gene:
Search GeneIP for patents involving MZT2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MZT2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MZT2B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MZT2B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MZT2B | | | OriGene Protein Over-expression Lysate for MZT2B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MZT2B | | OriGene 3'-UTR Clone for MZT2B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MZT2B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MZT2B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MZT2B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MZT2B | | OriGene Custom Protein Services for MZT2B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MZT2B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MZT2B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MZT2B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MZT2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MZT2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MZT2B |
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 |  |  |  | |
| | | | Search Tocris compounds for MZT2B |
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 | | | MZT2B Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for MZT2B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MZT2B |
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