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Aliases for MZT2B Gene

Aliases for MZT2B Gene

  • Mitotic Spindle Organizing Protein 2B 2 3
  • Mitotic-Spindle Organizing Protein Associated With A Ring Of Gamma-Tubulin 2B 2 3 4
  • MOZART2B 3 4 6
  • FAM128B 3 4 6
  • Family With Sequence Similarity 128, Member B 2 3
  • Mitotic-Spindle Organizing Protein 2B 3

External Ids for MZT2B Gene

Previous HGNC Symbols for MZT2B Gene

  • FAM128B

Previous GeneCards Identifiers for MZT2B Gene

  • GC02P130941
  • GC02P123235

Summaries for MZT2B Gene

GeneCards Summary for MZT2B Gene

MZT2B (Mitotic Spindle Organizing Protein 2B) is a Protein Coding gene. An important paralog of this gene is MZT2A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MZT2B Gene

Genomics for MZT2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MZT2B Gene

130,181,737 bp from pter
130,190,729 bp from pter
8,993 bases
Plus strand

Genomic View for MZT2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MZT2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MZT2B Gene

No data available for Regulatory Elements for MZT2B Gene

Proteins for MZT2B Gene

  • Protein details for MZT2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitotic-spindle organizing protein 2B
    Protein Accession:
    Secondary Accessions:
    • Q96CG4

    Protein attributes for MZT2B Gene

    158 amino acids
    Molecular mass:
    16226 Da
    Quaternary structure:
    • Part of the gamma-tubulin complex. Interacts with TUBG1.

neXtProt entry for MZT2B Gene

Proteomics data for MZT2B Gene at MOPED

Post-translational modifications for MZT2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MZT2B Gene

No data available for DME Specific Peptides for MZT2B Gene

Domains for MZT2B Gene

Protein Domains for MZT2B Gene


Suggested Antigen Peptide Sequences for MZT2B Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6NZ67
  • Belongs to the MOZART2 family.
genes like me logo Genes that share domains with MZT2B: view

No data available for Gene Families for MZT2B Gene

Function for MZT2B Gene

Gene Ontology (GO) - Molecular Function for MZT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20360068
genes like me logo Genes that share ontologies with MZT2B: view

Animal Model Products

miRNA for MZT2B Gene

miRTarBase miRNAs that target MZT2B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MZT2B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MZT2B Gene

Localization for MZT2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MZT2B Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

Jensen Localization Image for MZT2B Gene COMPARTMENTS Subcellular localization image for MZT2B gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for MZT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 20360068
GO:0005819 spindle IDA 20360068
GO:0008274 gamma-tubulin ring complex IDA 20360068
genes like me logo Genes that share ontologies with MZT2B: view

Pathways for MZT2B Gene

SuperPathways for MZT2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MZT2B Gene


No data available for Pathways by source for MZT2B Gene

Transcripts for MZT2B Gene

Unigene Clusters for MZT2B Gene

Mitotic spindle organizing protein 2B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MZT2B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MZT2B Gene

No ASD Table

Relevant External Links for MZT2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MZT2B Gene

mRNA expression in normal human tissues for MZT2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MZT2B Gene

This gene is overexpressed in Bone (40.0) and Pancreas (13.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MZT2B Gene

SOURCE GeneReport for Unigene cluster for MZT2B Gene Hs.469925

genes like me logo Genes that share expressions with MZT2B: view

Expression partners for MZT2B Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MZT2B Gene

Orthologs for MZT2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MZT2B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC787548 35
  • 87.47 (n)
  • 82.27 (a)
MZT2 36
  • 82 (a)
(Canis familiaris)
Mammalia MZT2B 35
  • 91.02 (n)
  • 94.33 (a)
-- 36
  • 94 (a)
(Pan troglodytes)
Mammalia MZT2B 35
  • 99.16 (n)
  • 99.37 (a)
(Mus musculus)
Mammalia Mzt2 16
Mzt2 36
  • 70 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
(Gallus gallus)
Aves -- 36
  • 54 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 41 (a)
-- 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mzt2b 35
  • 60.43 (n)
  • 56.13 (a)
(Danio rerio)
Actinopterygii mzt2b 35
  • 59.06 (n)
  • 57.89 (a)
mzt2b 36
  • 35 (a)
Species with no ortholog for MZT2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MZT2B Gene

Gene Tree for MZT2B (if available)
Gene Tree for MZT2B (if available)

Paralogs for MZT2B Gene

Paralogs for MZT2B Gene

Selected SIMAP similar genes for MZT2B Gene using alignment to 5 proteins: Pseudogenes for MZT2B Gene

genes like me logo Genes that share paralogs with MZT2B: view

Variants for MZT2B Gene

Sequence variations from dbSNP and Humsavar for MZT2B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs12408 -- 130,190,585(+) CCAAG(G/T)GGGGC reference, missense
rs705091 -- 130,190,533(+) CGCGA(A/G)GGATC reference, synonymous-codon, missense
rs1043059 - 130,190,502(+) GGGAG(C/T)ATTGG reference, missense, synonymous-codon
rs1043073 -- 130,190,529(+) CAGCC(A/G/T)CGAAG missense, reference, synonymous-codon
rs1043152 - 130,190,613(+) TACAC(A/G)GGGCA missense, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MZT2B Gene

Variant ID Type Subtype PubMed ID
nsv821629 CNV Loss 15273396
nsv459274 CNV Loss 19166990
dgv1247e1 CNV Complex 17122850
esv2751826 CNV Gain 17911159
dgv1249e1 CNV Complex 17122850
dgv1250e1 CNV Complex 17122850
nsv428403 CNV Loss 18775914
dgv4305n71 CNV Gain 21882294
dgv4306n71 CNV Gain 21882294
essv1878 CNV CNV 17122850
nsv875061 CNV Gain 21882294
nsv834375 CNV Loss 17160897
nsv7327 OTHER Inversion 18451855
nsv875074 CNV Gain 21882294
dgv4307n71 CNV Gain 21882294
nsv520559 CNV Gain+Loss 19592680
nsv875084 CNV Gain+Loss 21882294
nsv482053 CNV Gain 20164927
nsv875086 CNV Gain 21882294
nsv875087 CNV Gain 21882294
dgv4308n71 CNV Gain 21882294
nsv470485 CNV Gain 18288195
nsv818080 CNV Gain 17921354
dgv475n27 CNV Gain 19166990
essv2399 CNV CNV 17122850

Relevant External Links for MZT2B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MZT2B Gene

Disorders for MZT2B Gene

(1) University of Copenhagen DISEASES for MZT2B Gene

Relevant External Links for MZT2B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MZT2B: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for MZT2B Gene

Publications for MZT2B Gene

  1. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 2 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. CDK5RAP2 stimulates microtubule nucleation by the gamma-tubulin ring complex. (PMID: 21135143) Choi Y.K. … Qi R.Z. (J. Cell Biol. 2010) 3
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. Proteomic profiling of Myc-associated proteins. (PMID: 21150319) Agrawal P. … Sedivy J.M. (Cell Cycle 2010) 3

Products for MZT2B Gene

Sources for MZT2B Gene

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