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Aliases for MZT2A Gene

Aliases for MZT2A Gene

  • Mitotic Spindle Organizing Protein 2A 2 3 5
  • Mitotic-Spindle Organizing Protein Associated With A Ring Of Gamma-Tubulin 2A 2 3 4
  • Family With Sequence Similarity 128, Member A 2 3
  • MOZART2A 3 4
  • FAM128A 3 4
  • Mitotic-Spindle Organizing Protein 2A 3

External Ids for MZT2A Gene

Previous HGNC Symbols for MZT2A Gene

  • FAM128A

Previous GeneCards Identifiers for MZT2A Gene

  • GC02M132241
  • GC02M124234
  • GC02M132257
  • GC02M132276
  • GC02M132288
  • GC02M132312
  • GC02M132333

Summaries for MZT2A Gene

GeneCards Summary for MZT2A Gene

MZT2A (Mitotic Spindle Organizing Protein 2A) is a Protein Coding gene. An important paralog of this gene is MZT2B.

Additional gene information for MZT2A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MZT2A Gene

Genomics for MZT2A Gene

GeneHancer (GH) Regulatory Elements for MZT2A Gene

Promoters and enhancers for MZT2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I131490 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 583.7 +0.2 174 3.9 HDGF SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 LOC150776 MZT2A MIR4784 ENSG00000272769
GH02I131527 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 19.5 -35.6 -35558 1.4 HDGF HDAC1 PKNOX1 SIN3A BMI1 ZNF2 ZBTB40 ZNF335 EGR1 ATF7 PIR48903 CCDC74A LOC150776 MZT2A GC02P131710 PIR38321
GH02I131476 Promoter 0.7 EPDnew 29.5 +16.6 16643 0.1 USF1 ZBTB33 TUBA3D MZT2A MIR4784
GH02I131488 Enhancer 0.5 dbSUPER 34.1 +3.9 3921 1.1 POLR2A EGR1 REST ZBTB33 EGR2 MZT2A MIR4784 TUBA3D
GH02I131478 Enhancer 0.4 dbSUPER 27.4 +14.0 14019 0.9 NCOA3 FOS LOC150776 MZT2A TUBA3D MIR4784
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MZT2A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MZT2A Gene

Genomic Locations for MZT2A Gene
chr2:131,464,900-131,492,743
(GRCh38/hg38)
Size:
27,844 bases
Orientation:
Minus strand
chr2:132,222,473-132,250,316
(GRCh37/hg19)

Genomic View for MZT2A Gene

Genes around MZT2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MZT2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MZT2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MZT2A Gene

Proteins for MZT2A Gene

  • Protein details for MZT2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P582-MZT2A_HUMAN
    Recommended name:
    Mitotic-spindle organizing protein 2A
    Protein Accession:
    Q6P582
    Secondary Accessions:
    • Q3SWV8
    • Q8WVB2

    Protein attributes for MZT2A Gene

    Size:
    158 amino acids
    Molecular mass:
    16221 Da
    Quaternary structure:
    • Part of the gamma-tubulin complex.
    SequenceCaution:
    • Sequence=AAX93252.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MZT2A Gene

Post-translational modifications for MZT2A Gene

Other Protein References for MZT2A Gene

No data available for DME Specific Peptides for MZT2A Gene

Domains & Families for MZT2A Gene

Gene Families for MZT2A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MZT2A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MZT2A Gene

Graphical View of Domain Structure for InterPro Entry

Q6P582

UniProtKB/Swiss-Prot:

MZT2A_HUMAN :
  • Belongs to the MOZART2 family.
Family:
  • Belongs to the MOZART2 family.
genes like me logo Genes that share domains with MZT2A: view

Function for MZT2A Gene

genes like me logo Genes that share phenotypes with MZT2A: view

miRNA for MZT2A Gene

miRTarBase miRNAs that target MZT2A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MZT2A Gene

Localization for MZT2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MZT2A Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MZT2A gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MZT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome ISS --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle ISS --
genes like me logo Genes that share ontologies with MZT2A: view

Pathways & Interactions for MZT2A Gene

SuperPathways for MZT2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MZT2A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MZT2A Gene

Drugs & Compounds for MZT2A Gene

No Compound Related Data Available

Transcripts for MZT2A Gene

mRNA/cDNA for MZT2A Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MZT2A Gene

Mitotic spindle organizing protein 2A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MZT2A Gene

No ASD Table

Relevant External Links for MZT2A Gene

GeneLoc Exon Structure for
MZT2A
ECgene alternative splicing isoforms for
MZT2A

Expression for MZT2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MZT2A Gene

Protein differential expression in normal tissues from HIPED for MZT2A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (54.0) and Fetal ovary (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MZT2A Gene



Protein tissue co-expression partners for MZT2A Gene

NURSA nuclear receptor signaling pathways regulating expression of MZT2A Gene:

MZT2A

SOURCE GeneReport for Unigene cluster for MZT2A Gene:

Hs.655067

Evidence on tissue expression from TISSUES for MZT2A Gene

  • Pancreas(4.3)
  • Heart(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with MZT2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MZT2A Gene

Orthologs for MZT2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MZT2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MZT2B 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 91 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MZT2 34
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mzt2b 33
  • 74.57 (n)
mouse
(Mus musculus)
Mammalia Mzt2 33 16 34
  • 73.76 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 53 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii mzt2b 34
  • 35 (a)
OneToMany
Species where no ortholog for MZT2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MZT2A Gene

ENSEMBL:
Gene Tree for MZT2A (if available)
TreeFam:
Gene Tree for MZT2A (if available)

Paralogs for MZT2A Gene

Paralogs for MZT2A Gene

(1) SIMAP similar genes for MZT2A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MZT2A Gene

genes like me logo Genes that share paralogs with MZT2A: view

Variants for MZT2A Gene

Sequence variations from dbSNP and Humsavar for MZT2A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000417197 -- 131,472,682(-) A/T genic_downstream_transcript_variant, intron_variant
rs1000676597 -- 131,471,562(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000752046 -- 131,470,772(-) C/T genic_downstream_transcript_variant, intron_variant
rs1001024406 -- 131,483,448(-) A/T genic_downstream_transcript_variant, intron_variant
rs1001305595 -- 131,477,504(-) C/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MZT2A Gene

Variant ID Type Subtype PubMed ID
dgv4075n100 CNV gain 25217958
dgv4077n100 CNV gain 25217958
dgv4079n100 CNV loss 25217958
dgv4080n100 CNV gain 25217958
dgv476n27 CNV loss 19166990
esv2670824 CNV deletion 23128226
esv2759092 CNV gain+loss 17122850
esv2760576 CNV gain+loss 21179565
esv34412 CNV gain 17911159
esv34704 CNV gain 17911159
esv3575300 CNV gain 25503493
esv3584079 CNV loss 25503493
esv3592483 CNV loss 21293372
esv3592484 CNV gain 21293372
esv3893359 CNV gain+loss 25118596
nsv1002963 CNV gain 25217958
nsv1006738 CNV gain 25217958
nsv1008539 CNV gain 25217958
nsv1014682 CNV loss 25217958
nsv428404 CNV loss 18775914
nsv459396 CNV gain 19166990
nsv470486 CNV loss 18288195
nsv524021 CNV loss 19592680
nsv583140 CNV gain 21841781
nsv583143 CNV gain+loss 21841781
nsv583145 CNV loss 21841781
nsv7327 OTHER inversion 18451855
nsv834376 CNV gain 17160897
nsv979124 CNV duplication 23825009
nsv997248 CNV loss 25217958

Variation tolerance for MZT2A Gene

Gene Damage Index Score: 7.64; 82.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MZT2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MZT2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MZT2A Gene

Disorders for MZT2A Gene

Additional Disease Information for MZT2A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MZT2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MZT2A Gene

Publications for MZT2A Gene

  1. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins JR … Peters JM (Science (New York, N.Y.) 2010) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58

Products for MZT2A Gene

Sources for MZT2A Gene

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