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Aliases for MZT2A Gene

Aliases for MZT2A Gene

  • Mitotic Spindle Organizing Protein 2A 2 3 5
  • Mitotic-Spindle Organizing Protein Associated With A Ring Of Gamma-Tubulin 2A 2 3 4
  • Family With Sequence Similarity 128, Member A 2 3
  • MOZART2A 3 4
  • FAM128A 3 4
  • Mitotic-Spindle Organizing Protein 2A 3

External Ids for MZT2A Gene

Previous HGNC Symbols for MZT2A Gene

  • FAM128A

Previous GeneCards Identifiers for MZT2A Gene

  • GC02M132241
  • GC02M124234
  • GC02M132257
  • GC02M132276
  • GC02M132288
  • GC02M132312
  • GC02M132333

Summaries for MZT2A Gene

GeneCards Summary for MZT2A Gene

MZT2A (Mitotic Spindle Organizing Protein 2A) is a Protein Coding gene. An important paralog of this gene is MZT2B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MZT2A Gene

Genomics for MZT2A Gene

Regulatory Elements for MZT2A Gene

Enhancers for MZT2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G131490 1.4 ENCODE dbSUPER 33.6 +0.2 174 3.9 HDGF HNRNPUL1 FOXA2 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B LOC150776 MZT2A ENSG00000272769 MIR4784
GH02G131488 0.6 dbSUPER 34 +3.9 3922 1.1 POLR2A SMARCA4 EGR1 ZBTB33 REST RBFOX2 EGR2 MZT2A MIR4784 TUBA3D
GH02G131478 0.4 dbSUPER 27.4 +14.0 14019 0.9 FOS LOC150776 MZT2A TUBA3D MIR4784
GH02G131511 0.8 ENCODE 11.8 -19.3 -19251 1.7 SOX13 HDGF CTCF PKNOX1 MXI1 RBBP5 PLRG1 ZNF48 RAD21 CTBP1 LOC150776 MZT2A PIR47056
GH02G131419 0.6 dbSUPER 8.7 +72.0 72035 2.7 RNF2 L3MBTL2 ZNF341 TEAD4 MAX NFE2 ZIC2 FOXA1 LOC150776 MZT2A GNAQP1 GC02P131604 PIR43317
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MZT2A on UCSC Golden Path with GeneCards custom track

Promoters for MZT2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000123165 -57 2801 HDGF HNRNPUL1 FOXA2 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B

Genomic Location for MZT2A Gene

Chromosome:
2
Start:
131,464,900 bp from pter
End:
131,492,743 bp from pter
Size:
27,844 bases
Orientation:
Minus strand

Genomic View for MZT2A Gene

Genes around MZT2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MZT2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MZT2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MZT2A Gene

Proteins for MZT2A Gene

  • Protein details for MZT2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P582-MZT2A_HUMAN
    Recommended name:
    Mitotic-spindle organizing protein 2A
    Protein Accession:
    Q6P582
    Secondary Accessions:
    • Q3SWV8
    • Q8WVB2

    Protein attributes for MZT2A Gene

    Size:
    158 amino acids
    Molecular mass:
    16221 Da
    Quaternary structure:
    • Part of the gamma-tubulin complex.
    SequenceCaution:
    • Sequence=AAX93252.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MZT2A Gene

Post-translational modifications for MZT2A Gene

  • Ubiquitination at posLast=110110
  • Modification sites at PhosphoSitePlus

Other Protein References for MZT2A Gene

No data available for DME Specific Peptides for MZT2A Gene

Domains & Families for MZT2A Gene

Protein Domains for MZT2A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MZT2A Gene

Graphical View of Domain Structure for InterPro Entry

Q6P582

UniProtKB/Swiss-Prot:

MZT2A_HUMAN :
  • Belongs to the MOZART2 family.
Family:
  • Belongs to the MOZART2 family.
genes like me logo Genes that share domains with MZT2A: view

No data available for Gene Families for MZT2A Gene

Function for MZT2A Gene

genes like me logo Genes that share phenotypes with MZT2A: view

Animal Model Products

CRISPR Products

miRNA for MZT2A Gene

miRTarBase miRNAs that target MZT2A

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MZT2A Gene

Localization for MZT2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MZT2A Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MZT2A gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for MZT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome ISS --
GO:0005815 microtubule organizing center IDA --
GO:0005819 spindle ISS --
genes like me logo Genes that share ontologies with MZT2A: view

Pathways & Interactions for MZT2A Gene

SuperPathways for MZT2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MZT2A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MZT2A Gene

Transcripts for MZT2A Gene

mRNA/cDNA for MZT2A Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MZT2A Gene

Mitotic spindle organizing protein 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MZT2A Gene

No ASD Table

Relevant External Links for MZT2A Gene

GeneLoc Exon Structure for
MZT2A
ECgene alternative splicing isoforms for
MZT2A

Expression for MZT2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MZT2A Gene

Protein differential expression in normal tissues from HIPED for MZT2A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (54.0) and Fetal ovary (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MZT2A Gene



Protein tissue co-expression partners for MZT2A Gene

NURSA nuclear receptor signaling pathways regulating expression of MZT2A Gene:

MZT2A

SOURCE GeneReport for Unigene cluster for MZT2A Gene:

Hs.655067

Evidence on tissue expression from TISSUES for MZT2A Gene

  • Pancreas(4.3)
  • Heart(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with MZT2A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MZT2A Gene

Orthologs for MZT2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MZT2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MZT2B 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 91 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MZT2 35
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mzt2b 34
  • 74.57 (n)
mouse
(Mus musculus)
Mammalia Mzt2 34 16 35
  • 73.76 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 53 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii mzt2b 35
  • 35 (a)
OneToMany
Species where no ortholog for MZT2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MZT2A Gene

ENSEMBL:
Gene Tree for MZT2A (if available)
TreeFam:
Gene Tree for MZT2A (if available)

Paralogs for MZT2A Gene

Paralogs for MZT2A Gene

(1) SIMAP similar genes for MZT2A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MZT2A Gene

genes like me logo Genes that share paralogs with MZT2A: view

Variants for MZT2A Gene

Sequence variations from dbSNP and Humsavar for MZT2A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000417197 -- 131,472,682(+) GCTAT(A/T)CCATG intron-variant
rs1000676597 -- 131,471,562(+) AGGAG(C/T)TATGG intron-variant
rs1000752046 -- 131,470,772(+) CAGGC(C/T)AGGCA intron-variant
rs1001024406 -- 131,483,448(+) CACAC(A/T)GCAAC intron-variant
rs1001305595 -- 131,477,504(+) GGATT(C/G)AGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MZT2A Gene

Variant ID Type Subtype PubMed ID
dgv4075n100 CNV gain 25217958
dgv4077n100 CNV gain 25217958
dgv4079n100 CNV loss 25217958
dgv4080n100 CNV gain 25217958
dgv476n27 CNV loss 19166990
esv2670824 CNV deletion 23128226
esv2759092 CNV gain+loss 17122850
esv2760576 CNV gain+loss 21179565
esv34412 CNV gain 17911159
esv34704 CNV gain 17911159
esv3575300 CNV gain 25503493
esv3584079 CNV loss 25503493
esv3592483 CNV loss 21293372
esv3592484 CNV gain 21293372
esv3893359 CNV gain+loss 25118596
nsv1002963 CNV gain 25217958
nsv1006738 CNV gain 25217958
nsv1008539 CNV gain 25217958
nsv1014682 CNV loss 25217958
nsv428404 CNV loss 18775914
nsv459396 CNV gain 19166990
nsv470486 CNV loss 18288195
nsv524021 CNV loss 19592680
nsv583140 CNV gain 21841781
nsv583143 CNV gain+loss 21841781
nsv583145 CNV loss 21841781
nsv7327 OTHER inversion 18451855
nsv834376 CNV gain 17160897
nsv979124 CNV duplication 23825009
nsv997248 CNV loss 25217958

Variation tolerance for MZT2A Gene

Gene Damage Index Score: 7.64; 82.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MZT2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MZT2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MZT2A Gene

Disorders for MZT2A Gene

Relevant External Links for MZT2A

Genetic Association Database (GAD)
MZT2A
Human Genome Epidemiology (HuGE) Navigator
MZT2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MZT2A

No disorders were found for MZT2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MZT2A Gene

Publications for MZT2A Gene

  1. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  5. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3 64

Products for MZT2A Gene

Sources for MZT2A Gene

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