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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MZT2A Gene

protein-coding GIFtS: 40
GCID: GC02M132288

mitotic spindle organizing protein 2A

(Previous names: family with sequence similarity 128, member A )
(Previous symbol: FAM128A)

Explore 1 disease affiliated with
MZT2A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mitotic Spindle Organizing Protein 2A¹ ²
FAM128A¹ ² ³ ⁵
MOZART2A¹ ² ³ ⁵
Family With Sequence Similarity 128, Member A¹ ²
Mitotic-Spindle Organizing Protein Associated With A Ring Of Gamma-Tubulin 2A² ³
Mitotic-Spindle Organizing Protein 2A²

External Ids:	HGNC: 33187¹	Entrez Gene: 653784²	Ensembl: ENSG00000173272⁷	OMIM: 613449⁵	UniProtKB: Q6P582³

Export aliases for MZT2A gene to outside databases

Previous GC identifers: GC02M132241 GC02M124234 GC02M132257 GC02M132276

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022135.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for MZT2A
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for MZT2A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MZT2A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1 Ensembl cytogenetic band: 2q21.1 HGNC cytogenetic band: 2q21.1

MZT2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MZT2A gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M132288: view genomic region (about GC identifiers)

Start:	132,222,473 bp from pter	End:	132,250,316 bp from pter
Size:	27,844 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MZT2A_HUMAN, Q6P582 (See protein sequence)

Recommended Name: Mitotic-spindle organizing protein 2A

Size: 158 amino acids; 16221 Da

Subunit: Part of the gamma-tubulin complex

Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle

Sequence caution: Sequence=AAX93252.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: Q3SWV8 Q8WVB2

Explore the universe of human proteins at neXtProt for MZT2A: NX_Q6P582

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6P582

MZT2A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001078834.1

ENSEMBL proteins:

ENSP00000403353 ENSP00000311500

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005813	centrosome	ISS	--
GO:0005819	spindle	ISS	--
GO:0008274	gamma-tubulin ring complex	ISS	--

MZT2A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MZT2A for domains About GeneDecksing

1 InterPro domain/family:

IPR024332 MOZART2

Graphical View of Domain Structure for InterPro Entry Q6P582

ProtoNet protein and cluster: Q6P582

UniProtKB/Swiss-Prot: MZT2A_HUMAN, Q6P582

Similarity: Belongs to the MOZART2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MZT2A

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/11 Interacting proteins for MZT2A (Q6P582³ ENSP00000311500⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IKBKG	Q9Y6K9³, ENSP00000358622⁴	I2D: score=1 STRING: ENSP00000358622
MAPK3	P27361³	I2D: score=1
BRCA1	ENSP00000350283⁴	STRING: ENSP00000350283
CENPJ	ENSP00000371308⁴	STRING: ENSP00000371308
MZT1	ENSP00000367049⁴	STRING: ENSP00000367049

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for MZT2A gene:

NM_001085365.1

Unigene Cluster for MZT2A:

Mitotic spindle organizing protein 2A

Hs.655067 [show with all ESTs]

Unigene Representative Sequence: AK090531

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000427024 ENST00000445782 ENST00000410036 ENST00000309451(uc002tsv.4 uc002tsw.4)

ENST00000488586 ENST00000491265

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Additional cDNA sequence:

AK090531.1 BC018206.1 BC063024.1 BC104650.1

22 DOTS entries:

DT.95357791 DT.100040544 DT.95357792 DT.40285940 DT.95287225 DT.95288728 DT.91882168 DT.100045721

DT.40234559 DT.92470739 DT.95148741 DT.97864757 DT.100770995 DT.120980873 DT.120981255 DT.100687923

DT.95197752 DT.100812250 DT.120980939 DT.435893 DT.97864761 DT.99987549

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MZT2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTACCTCCTT

About this image

MZT2A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MZT2A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MZT2A

SOURCE GeneReport for Unigene cluster: Hs.655067

SABiosciences Custom PCR Arrays for MZT2A

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MZT2A gene from 3/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	--	Uncharacterized protein	58(a)	1 → many	10(203409-212444)
lizard (Anolis carolinensis)	Reptilia	--	--	49(a)	1 → many	GL343669.1(98159-98380)
zebrafish (Danio rerio)	Actinopterygii	zgc:101080⁶	zgc:101080	35(a)	1 → many	21(14282192-14290948)

Species with no ortholog for MZT2A

ENSEMBL Gene Tree for MZT2A (if available)
TreeFam Gene Tree for MZT2A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MZT2A gene

MZT2B²

1 SIMAP similar gene for MZT2A using alignment to 2 protein entries: MZT2A_HUMAN (see all proteins):

MZT2B

MZT2A for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for MZT2A
PGOHUM00000250320 PGOHUM00000240912

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139779366^1,2		--	132241048(+)	`GTCAAC/TTGTCT`	1	--	ds500¹		0	--	--	--	--
rs183222447^1,2		--	132241115(+)	`AACCCC/TGTCTC`	1	--	ds500¹		0	--	--	--	--
rs61104316^1,2	C,F,	--	132241135(+)	`TACAAC/TAAAAC`	1	--	ds500¹		2		WA CSA	4
rs113133794^1,2	C,	--	132241161(+)	`GGGCAC/-CTGTA`	1	--	ds500¹		1		CSA	2
rs145447600^1,2		--	132241205(+)	`ATGGCA/GCGAAC`	1	--	ds500¹		0	--	--	--	--
rs201050684^1,2		--	132241309(+)	`AACAA-/ACAAAAA`	1	--	ds500¹		0	--	--	--	--
rs12475060^1,2	C,F,H,	--	132241310(+)	`ACAAAA/CAAAAA`	1	--	ds500¹		4		NA CSA	11
rs199569741^1,2		--	132241310(+)	`ACAAA-/CAAAAA`	1	--	ds500¹		0	--	--	--	--
rs192480613^1,2		--	132241368(+)	`AAAGAC/TCTGGC`	1	--	ds500¹		0	--	--	--	--
rs182525142^1,2		--	132241449(+)	`GTTCAC/TTGTGG`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MZT2A (132222473 - 132250316 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MZT2A: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MZT2A for disorders           About GeneDecksing

OMIM gene information: 613449    OMIM disorders: --

1 disease for MZT2A:    About MalaCards

microcephaly

1 disease from the University of Copenhagen DISEASES database for MZT2A:

Microcephaly

Human Genome Epidemiology (HuGE) Navigator: MZT2A (3 documents)

Export disorders for MZT2A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MZT2A gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with MZT2A)

Utopia: connect your pdf to the dynamic
world of online information

Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)^{1, 2, 3} Hutchins J.R....Peters J.M. (2010)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
The gammaTuRC revisited: a comparative analysis of in terphase and mitotic human gammaTuRC redefines the set of core components and i dentifies the novel subunit GCP8. (PubMed id 20861304)¹ TeixidA^-Travesa N....LA1ders J. (2010)
CDK5RAP2 stimulates microtubule nucleation by the gamm a-tubulin ring complex. (PubMed id 21135143)¹ Choi Y.K....Qi R.Z. (2010)
Expanding the substantial interactome of NEMO using p rotein microarrays. (PubMed id 20098747)¹ Fenner B.J....Prehn J.H. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 653784	HGNC: 33187	Ensembl:ENSG00000173272	euGenes: HUgn653784	ECgene: MZT2A
H-InvDB: MZT2A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MZT2A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MZT2A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MZT2A gene:
Search GeneIP for patents involving MZT2A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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MZT2A Gene

mitotic spindle organizing protein 2A

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MZT2A Gene

mitotic spindle organizing protein 2A

Aliasesfor MZT2A gene

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