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Aliases for MZT2A Gene

Aliases for MZT2A Gene

  • Mitotic Spindle Organizing Protein 2A 2 3
  • Mitotic-Spindle Organizing Protein Associated With A Ring Of Gamma-Tubulin 2A 2 3 4
  • Family With Sequence Similarity 128, Member A 2 3
  • MOZART2A 3 4
  • FAM128A 3 4

External Ids for MZT2A Gene

Previous HGNC Symbols for MZT2A Gene

  • FAM128A

Previous GeneCards Identifiers for MZT2A Gene

  • GC02M132241
  • GC02M124234
  • GC02M132257
  • GC02M132276
  • GC02M132288
  • GC02M132312
  • GC02M132333

Summaries for MZT2A Gene

GeneCards Summary for MZT2A Gene

MZT2A (Mitotic Spindle Organizing Protein 2A) is a Protein Coding gene. An important paralog of this gene is MZT2B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MZT2A Gene

Genomics for MZT2A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MZT2A Gene

Chromosome:
2
Start:
131,464,900 bp from pter
End:
131,492,743 bp from pter
Size:
27,844 bases
Orientation:
Minus strand

Genomic View for MZT2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MZT2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MZT2A Gene

No data available for Regulatory Elements for MZT2A Gene

Proteins for MZT2A Gene

  • Protein details for MZT2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P582-MZT2A_HUMAN
    Recommended name:
    Mitotic-spindle organizing protein 2A
    Protein Accession:
    Q6P582
    Secondary Accessions:
    • Q3SWV8
    • Q8WVB2

    Protein attributes for MZT2A Gene

    Size:
    158 amino acids
    Molecular mass:
    16221 Da
    Quaternary structure:
    • Part of the gamma-tubulin complex.
    SequenceCaution:
    • Sequence=AAX93252.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MZT2A Gene

Proteomics data for MZT2A Gene at MOPED

Post-translational modifications for MZT2A Gene

  • Ubiquitination at Lys 110
  • Modification sites at PhosphoSitePlus

Other Protein References for MZT2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MZT2A Gene

Domains & Families for MZT2A Gene

Protein Domains for MZT2A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MZT2A Gene

Graphical View of Domain Structure for InterPro Entry

Q6P582

UniProtKB/Swiss-Prot:

MZT2A_HUMAN :
  • Belongs to the MOZART2 family.
Family:
  • Belongs to the MOZART2 family.
genes like me logo Genes that share domains with MZT2A: view

No data available for Gene Families for MZT2A Gene

Function for MZT2A Gene

Phenotypes for MZT2A Gene

genes like me logo Genes that share phenotypes with MZT2A: view

Animal Model Products

CRISPR Products

miRNA for MZT2A Gene

miRTarBase miRNAs that target MZT2A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MZT2A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for MZT2A Gene

Localization for MZT2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MZT2A Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MZT2A Gene COMPARTMENTS Subcellular localization image for MZT2A gene
Compartment Confidence
cytoskeleton 5

Gene Ontology (GO) - Cellular Components for MZT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome ISS --
GO:0005819 spindle ISS --
GO:0008274 gamma-tubulin ring complex ISS --
genes like me logo Genes that share ontologies with MZT2A: view

Pathways & Interactions for MZT2A Gene

SuperPathways for MZT2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MZT2A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MZT2A Gene

Drugs & Compounds for MZT2A Gene

No Compound Related Data Available

Transcripts for MZT2A Gene

mRNA/cDNA for MZT2A Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MZT2A Gene

Mitotic spindle organizing protein 2A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MZT2A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MZT2A Gene

No ASD Table

Relevant External Links for MZT2A Gene

GeneLoc Exon Structure for
MZT2A
ECgene alternative splicing isoforms for
MZT2A

Expression for MZT2A Gene

mRNA expression in normal human tissues for MZT2A Gene

Protein differential expression in normal tissues from HIPED for MZT2A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (54.0) and Fetal ovary (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MZT2A Gene



SOURCE GeneReport for Unigene cluster for MZT2A Gene Hs.655067

genes like me logo Genes that share expression patterns with MZT2A: view

Protein tissue co-expression partners for MZT2A Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MZT2A Gene

Orthologs for MZT2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MZT2A Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Mzt2 35
  • 73.76 (n)
  • 69.68 (a)
Mzt2 36
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mzt2b 35
  • 74.57 (n)
  • 71.15 (a)
cow
(Bos Taurus)
Mammalia MZT2 36
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 91 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia MZT2B 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii mzt2b 36
  • 35 (a)
OneToMany
Species with no ortholog for MZT2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MZT2A Gene

ENSEMBL:
Gene Tree for MZT2A (if available)
TreeFam:
Gene Tree for MZT2A (if available)

Paralogs for MZT2A Gene

Paralogs for MZT2A Gene

(1) SIMAP similar genes for MZT2A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MZT2A Gene

genes like me logo Genes that share paralogs with MZT2A: view

Variants for MZT2A Gene

Sequence variations from dbSNP and Humsavar for MZT2A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs719314 -- 131,485,513(-) tgcag(C/T)gtgcc intron-variant
rs1823652 -- 131,485,510(-) agcgt(A/G)ccctc intron-variant
rs2314124 -- 131,485,636(+) gtccc(A/G/T)tgtgg intron-variant
rs2314125 -- 131,485,639(+) CCGTG(C/T)GGGAA intron-variant
rs2463336 -- 131,484,862(-) TGGTG(G/T)TCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MZT2A Gene

Variant ID Type Subtype PubMed ID
dgv1247e1 CNV Complex 17122850
nsv7327 OTHER Inversion 18451855
esv2670824 CNV Deletion 23128226
nsv524021 CNV Loss 19592680
dgv1252e1 CNV Complex 17122850
dgv1254e1 CNV Complex 17122850
nsv428404 CNV Loss 18775914
dgv1256e1 CNV Complex 17122850
esv34412 CNV Gain 17911159
dgv4312n71 CNV Loss 21882294
dgv4313n71 CNV Gain 21882294
dgv476n27 CNV Loss 19166990
nsv459396 CNV Gain 19166990
nsv470486 CNV Loss 18288195
nsv875115 CNV Gain 21882294
esv34704 CNV Gain 17911159
essv2396 CNV CNV 17122850
dgv1257e1 CNV Complex 17122850
essv1836 CNV CNV 17122850
dgv4314n71 CNV Gain 21882294
essv7878 CNV CNV 17122850
dgv1258e1 CNV Complex 17122850
nsv834376 CNV Gain 17160897

Variation tolerance for MZT2A Gene

Gene Damage Index Score: 7.64; 82.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MZT2A Gene

HapMap Linkage Disequilibrium report
MZT2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MZT2A Gene

Disorders for MZT2A Gene

Relevant External Links for MZT2A

Genetic Association Database (GAD)
MZT2A
Human Genome Epidemiology (HuGE) Navigator
MZT2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MZT2A
genes like me logo Genes that share disorders with MZT2A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MZT2A Gene

Publications for MZT2A Gene

  1. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 2 67
  2. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 67
  3. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 67
  4. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PMID: 21399614) Jakobsen L. … Andersen J.S. (EMBO J. 2011) 67
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67

Products for MZT2A Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MZT2A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MZT2A
    • Block miRNA regulation of MZT2A using miScript Target Protectors

    Sources for MZT2A Gene

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