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Aliases for MZT1 Gene

Aliases for MZT1 Gene

  • Mitotic Spindle Organizing Protein 1 2 3 5
  • Mitotic-Spindle Organizing Protein Associated With A Ring Of Gamma-Tubulin 1 2 3 4
  • C13orf37 3 4
  • MOZART1 3 4
  • Chromosome 13 Open Reading Frame 37 2

External Ids for MZT1 Gene

Previous HGNC Symbols for MZT1 Gene

  • C13orf37

Previous GeneCards Identifiers for MZT1 Gene

  • GC13M073283
  • GC13M053980
  • GC13M073288
  • GC13M073291
  • GC13M073297

Summaries for MZT1 Gene

GeneCards Summary for MZT1 Gene

MZT1 (Mitotic Spindle Organizing Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MZT1 Gene

  • Required for gamma-tubulin complex recruitment to the centrosome.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MZT1 Gene

Genomics for MZT1 Gene

Regulatory Elements for MZT1 Gene

Enhancers for MZT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MZT1 on UCSC Golden Path with GeneCards custom track

Promoters for MZT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MZT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MZT1 Gene

72,708,357 bp from pter
72,727,800 bp from pter
19,444 bases
Minus strand

Genomic View for MZT1 Gene

Genes around MZT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MZT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MZT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MZT1 Gene

Proteins for MZT1 Gene

  • Protein details for MZT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitotic-spindle organizing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5W0P5

    Protein attributes for MZT1 Gene

    82 amino acids
    Molecular mass:
    8479 Da
    Quaternary structure:
    • Part of the gamma-tubulin complex. Interacts with TUBG1.

neXtProt entry for MZT1 Gene

Proteomics data for MZT1 Gene at MOPED

Post-translational modifications for MZT1 Gene

  • Ubiquitination at Lys 65 and Lys 75
  • Modification sites at PhosphoSitePlus

Other Protein References for MZT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MZT1 Gene

Domains & Families for MZT1 Gene

Protein Domains for MZT1 Gene


Suggested Antigen Peptide Sequences for MZT1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MOZART1 family.
  • Belongs to the MOZART1 family.
genes like me logo Genes that share domains with MZT1: view

No data available for Gene Families for MZT1 Gene

Function for MZT1 Gene

Molecular function for MZT1 Gene

UniProtKB/Swiss-Prot Function:
Required for gamma-tubulin complex recruitment to the centrosome.

Phenotypes for MZT1 Gene

GenomeRNAi human phenotypes for MZT1:
genes like me logo Genes that share phenotypes with MZT1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MZT1 Gene

Localization for MZT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MZT1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

Jensen Localization Image for MZT1 Gene COMPARTMENTS Subcellular localization image for MZT1 gene
Compartment Confidence
cytoskeleton 5
extracellular 2
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MZT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005819 spindle IDA 20360068
genes like me logo Genes that share ontologies with MZT1: view

Pathways & Interactions for MZT1 Gene

SuperPathways for MZT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MZT1 Gene


No data available for Pathways by source and SIGNOR curated interactions for MZT1 Gene

Drugs & Compounds for MZT1 Gene

No Compound Related Data Available

Transcripts for MZT1 Gene

mRNA/cDNA for MZT1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(131) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MZT1 Gene

Mitotic spindle organizing protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MZT1 Gene

No ASD Table

Relevant External Links for MZT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MZT1 Gene

mRNA expression in normal human tissues for MZT1 Gene

mRNA differential expression in normal tissues according to GTEx for MZT1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.3) and Brain - Caudate (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for MZT1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.4), Fetal ovary (13.5), Colon (7.3), and Fetal Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MZT1 Gene

SOURCE GeneReport for Unigene cluster for MZT1 Gene Hs.28465

genes like me logo Genes that share expression patterns with MZT1: view

Protein tissue co-expression partners for MZT1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MZT1 Gene

Orthologs for MZT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MZT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MZT1 35
  • 92.93 (n)
  • 98.48 (a)
MZT1 36
  • 91 (a)
(Canis familiaris)
Mammalia MZT1 35
  • 92.93 (n)
  • 98.48 (a)
MZT1 36
  • 91 (a)
(Mus musculus)
Mammalia Mzt1 35
  • 91.28 (n)
  • 95.38 (a)
Mzt1 16
Mzt1 36
  • 85 (a)
(Pan troglodytes)
Mammalia MZT1 35
  • 99.59 (n)
  • 100 (a)
MZT1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mzt1 35
  • 90.26 (n)
  • 95.38 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
-- 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia MZT1 36
  • 86 (a)
(Gallus gallus)
Aves MZT1 35
  • 85.35 (n)
  • 96.97 (a)
MZT1 36
  • 93 (a)
(Anolis carolinensis)
Reptilia MZT1 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mzt1 35
  • 77.27 (n)
  • 84.85 (a)
(Danio rerio)
Actinopterygii LOC100333194 35
  • 71.72 (n)
  • 86.36 (a)
MZT1 36
  • 55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for MZT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MZT1 Gene

Gene Tree for MZT1 (if available)
Gene Tree for MZT1 (if available)

Paralogs for MZT1 Gene Pseudogenes for MZT1 Gene

genes like me logo Genes that share paralogs with MZT1: view

No data available for Paralogs for MZT1 Gene

Variants for MZT1 Gene

Sequence variations from dbSNP and Humsavar for MZT1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_043562 -
rs7931 -- 72,710,273(+) TCTTC(A/T)AACCC nc-transcript-variant, utr-variant-3-prime
rs716660 -- 72,714,364(-) ttatg(C/T)tctgc intron-variant
rs765741 -- 72,723,312(+) CAAAT(C/T)GCCTG intron-variant
rs1046588 -- 72,718,994(+) ACCGA(A/C/T)GATAA nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MZT1 Gene

Variant ID Type Subtype PubMed ID
esv2747633 CNV Deletion 23290073
nsv826707 CNV Loss 20364138
esv2667348 CNV Deletion 23128226
esv2747634 CNV Deletion 23290073

Variation tolerance for MZT1 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MZT1 Gene

Disorders for MZT1 Gene

Relevant External Links for MZT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MZT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MZT1 Gene

Publications for MZT1 Gene

  1. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Genome-wide association study of obsessive-compulsive disorder. (PMID: 22889921) Stewart S.E. … Pauls D.L. (Mol. Psychiatry 2013) 3
  4. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3
  5. The GCP3-interacting proteins GIP1 and GIP2 are required for I^-tubulin complex protein localization, spindle integrity, and chromosomal stability. (PMID: 22427335) Janski N. … Schmit A.C. (Plant Cell 2012) 3

Products for MZT1 Gene

Sources for MZT1 Gene