MZT1 Gene
protein-coding GIFtS: 38
GCID: GC13M073288
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mitotic spindle organizing protein 1(Previous name: chromosome 13 open reading frame 37 )
(Previous symbol: C13orf37)
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Aliases
for MZT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitotic Spindle Organizing Protein 11 2 | | LOC4401451 | | C13orf371 2 3 5 | | MGC1505391 | | MOZART11 2 3 5 | | RP11-11C5.21 | | Mitotic-Spindle Organizing Protein Associated With A Ring Of Gamma-Tubulin 12 3 | | Chromosome 13 Open Reading Frame 371 | | FLJ218691 | | Mitotic-Spindle Organizing Protein 12 |
Export aliases for MZT1 gene to outside databasesPrevious GC identifers: GC13M073283 GC13M053980 |
Summaries
for MZT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MZT1_HUMAN, Q08AG7Function: Required for gamma-tubulin complex recruitment to the centrosome
|
Genomic Views
for MZT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MZT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MZT1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MZT1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q22.1 Ensembl cytogenetic band: 13q22.1 HGNC cytogenetic band: 13q22.1MZT1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M073288: view genomic region
(about GC identifiers)
Start:
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73,282,495 bp from pter |
End:
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73,301,938 bp from pter |
Size:
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19,444 bases |
Orientation:
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minus strand |
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Proteins
for MZT1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MZT1_HUMAN, Q08AG7 (See
protein sequence)Recommended Name: Mitotic-spindle organizing protein 1 Size: 82 amino acids; 8479 Da
Subunit: Part of the gamma-tubulin complex. Interacts with TUBG1
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle
Secondary accessions: Q5W0P5Explore the universe of human proteins at neXtProt for MZT1: NX_Q08AG7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q08AG7
MZT1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001065243.1
ENSEMBL proteins: ENSP00000367049
Human Recombinant Protein Products for MZT1:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MZT1 for ontologies About GeneDecksing
MZT1 Antibody Products:
Assay Products for MZT1: |
Protein
Domains /
Families
for MZT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MZT1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q08AG7ProtoNet protein and cluster: Q08AG7 UniProtKB/Swiss-Prot: MZT1_HUMAN, Q08AG7Similarity: Belongs to the MOZART1 family |
Function
for MZT1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MZT1_HUMAN, Q08AG7Function: Required for gamma-tubulin complex recruitment to the centrosome Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
MZT1 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MZT1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MZT1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MZT1 (NM_001071775) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MZT1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MZT1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MZT1 |
|
Pathways & Interactions
for MZT1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MZT1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/14 Interacting proteins for MZT1 (Q08AG71, 3 ENSP000003670494) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0033566 | gamma-tubulin complex localization |
IMP | -- |
MZT1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MZT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MZT1
Search CenterWatch for drugs/clinical trials and news about MZT1
|
Transcripts
for MZT1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MZT1 gene: NM_001071775.2 Unigene Cluster for MZT1: Mitotic spindle organizing protein 1 Hs.28465 [show with all ESTs]Unigene Representative Sequence: NM_0010717751 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000377818(uc001viu.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MZT1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MZT1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MZT1 (NM_001071775) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MZT1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MZT1 |
Additional cDNA sequence: AK025522.1 BC013405.2 BC047655.1 BC062361.1 BC080523.1 BC125183.1 7 DOTS entries: DT.91721611 DT.100025979 DT.75177640 DT.100771611 DT.314639 DT.100836581 DT.120788163 24/131 AceView cDNA sequences (see all 131): CK905713 BU181122 AA233576 CB528486 AA808901 AA322476 CF552384 CK429454 AI560392 BC080523 CB243243 CB111894 BM505627 BU069356 BM511975 BU624963 BG113220 CB270343 AL711005 BM508993 BM768649 CB267622 AW136776 BI549563
GeneLoc Exon Structure
|
Expression
for MZT1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MZT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAAATTCCT
About this image
See MZT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MZT1
SOURCE GeneReport for Unigene cluster: Hs.28465
SABiosciences Custom PCR Arrays for MZT1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MZT1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MZT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MZT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MZT1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MZT1 |
Orthologs
for MZT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MZT1 gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for MZT1 (if available)
TreeFam Gene Tree for MZT1 (if available) |
Paralogs
for MZT1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MZT1 gene
MZT1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for MZT1
PGOHUM00000244596 PGOHUM00000233592
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Genomic Variants
for MZT1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MZT1 (73282495 - 73301938 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MZT1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MZT1 |
|
Disorders
/ Diseases
for MZT1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MZT1 for disorders About MalaCards
MZT1 for disorders About GeneDecksing
OMIM gene information: 613448
OMIM disorders: --
Export disorders for MZT1 gene to outside databases
|
Publications
for MZT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MZT1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MZT1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1, 2, 3 Hutchins J.R....Peters J.M. (2010)
- Genome-wide association study of obsessive-compulsive disorder. (PubMed id 22889921)1 Stewart S.E....Pauls D.L. (2012)
- The GCP3-interacting proteins GIP1 and GIP2 are requir ed for g-tubulin complex protein localization, spindle integrity, and chromosoma l stability. (PubMed id 22427335)1 Janski N....Schmit A.C. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling. (PubMed id 20639865)1 Xu G....Jaffrey S.R. (2010)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for MZT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MZT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MZT1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MZT1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MZT1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MZT1 gene:
Search GeneIP for patents involving MZT1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MZT1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MZT1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MZT1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MZT1 | | | OriGene Protein Over-expression Lysate for MZT1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MZT1 | | OriGene 3'-UTR Clone for MZT1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MZT1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MZT1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MZT1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MZT1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MZT1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MZT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MZT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MZT1 |
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 | | | MZT1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MZT1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for MZT1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MZT1 |
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