Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MZT1 Gene

Aliases for MZT1 Gene

  • Mitotic Spindle Organizing Protein 1 2 3
  • Mitotic-Spindle Organizing Protein Associated With A Ring Of Gamma-Tubulin 1 2 3 4
  • C13orf37 3 4 6
  • MOZART1 3 4 6
  • Mitotic-Spindle Organizing Protein 1 3
  • Chromosome 13 Open Reading Frame 37 2

External Ids for MZT1 Gene

Previous Symbols for MZT1 Gene

  • C13orf37

Summaries for MZT1 Gene

GeneCards Summary for MZT1 Gene

MZT1 (Mitotic Spindle Organizing Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MZT1 Gene

  • Required for gamma-tubulin complex recruitment to the centrosome.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MZT1 Gene

Genomics for MZT1 Gene

Genomic Location for MZT1 Gene

Start:
72,708,357 bp from pter
End:
72,727,800 bp from pter
Size:
19,444 bases
Orientation:
Minus strand

Genomic View for MZT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MZT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MZT1 Gene

No data available for Regulatory Elements for MZT1 Gene

Proteins for MZT1 Gene

  • Protein details for MZT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08AG7-MZT1_HUMAN
    Recommended name:
    Mitotic-spindle organizing protein 1
    Protein Accession:
    Q08AG7
    Secondary Accessions:
    • Q5W0P5

    Protein attributes for MZT1 Gene

    Size:
    82 amino acids
    Molecular mass:
    8479 Da
    Quaternary structure:
    • Part of the gamma-tubulin complex. Interacts with TUBG1.

neXtProt entry for MZT1 Gene

Proteomics data for MZT1 Gene at MOPED

Post-translational modifications for MZT1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys65 and Lys75

Other Protein References for MZT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MZT1 Gene

Domains for MZT1 Gene

Protein Domains for MZT1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MZT1_HUMAN
Family:
  • Belongs to the MOZART1 family.:
    • Q08AG7
genes like me logo Genes that share domains with MZT1: view

No data available for Gene Families for MZT1 Gene

Function for MZT1 Gene

Molecular function for MZT1 Gene

UniProtKB/Swiss-Prot Function: Required for gamma-tubulin complex recruitment to the centrosome.

Gene Ontology (GO) - Molecular Function for MZT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20360068
genes like me logo Genes that share ontologies with MZT1: view

miRNA for MZT1 Gene

miRTarBase miRNAs that target MZT1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MZT1 Gene

Localization for MZT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MZT1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MZT1 Gene COMPARTMENTS Subcellular localization image for MZT1 gene
Compartment Confidence
cytoskeleton 5
extracellular 2
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MZT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 20360068
GO:0005819 spindle IDA 20360068
GO:0008274 gamma-tubulin ring complex IDA 20360068
genes like me logo Genes that share ontologies with MZT1: view

Pathways for MZT1 Gene

SuperPathways for MZT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MZT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033566 gamma-tubulin complex localization IMP 20360068
genes like me logo Genes that share ontologies with MZT1: view

No data available for Pathways by source for MZT1 Gene

Transcripts for MZT1 Gene

mRNA/cDNA for MZT1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(131) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MZT1 Gene

Mitotic spindle organizing protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MZT1 Gene

No ASD Table

Relevant External Links for MZT1 Gene

GeneLoc Exon Structure for
MZT1
ECgene alternative splicing isoforms for
MZT1

Expression for MZT1 Gene

mRNA expression in normal human tissues for MZT1 Gene

mRNA differential expression in normal tissues according to GTEx for MZT1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (4.3) and Brain - Caudate (basal ganglia) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MZT1 Gene

SOURCE GeneReport for Unigene cluster for MZT1 Gene Hs.28465

genes like me logo Genes that share expressions with MZT1: view

Orthologs for MZT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MZT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MZT1 36
  • 99.59 (n)
  • 100 (a)
MZT1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MZT1 36
  • 92.93 (n)
  • 98.48 (a)
MZT1 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MZT1 36
  • 92.93 (n)
  • 98.48 (a)
MZT1 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mzt1 36
  • 91.28 (n)
  • 95.38 (a)
Mzt1 16
Mzt1 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 90 (a)
OneToMany
-- 37
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MZT1 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mzt1 36
  • 90.26 (n)
  • 95.38 (a)
chicken
(Gallus gallus)
Aves MZT1 36
  • 85.35 (n)
  • 96.97 (a)
MZT1 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MZT1 37
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mzt1 36
  • 77.27 (n)
  • 84.85 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100333194 36
  • 71.72 (n)
  • 86.36 (a)
MZT1 37
  • 55 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 51 (a)
OneToOne
Species with no ortholog for MZT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MZT1 Gene

ENSEMBL:
Gene Tree for MZT1 (if available)
TreeFam:
Gene Tree for MZT1 (if available)

Paralogs for MZT1 Gene

Pseudogenes.org Pseudogenes for MZT1 Gene

genes like me logo Genes that share paralogs with MZT1: view

No data available for Paralogs for MZT1 Gene

Variants for MZT1 Gene

Sequence variations from dbSNP and Humsavar for MZT1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs7931 -- 72,710,273(+) TCTTC(A/T)AACCC utr-variant-3-prime
rs716660 -- 72,714,364(-) ttatg(C/T)tctgc intron-variant
rs765741 -- 72,723,312(+) CAAAT(C/T)GCCTG intron-variant
rs1046588 -- 72,718,994(+) ACCGA(A/T)GATAA reference, synonymous-codon
rs1372001 -- 72,723,441(-) CACTA(C/T)GGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MZT1 Gene

Variant ID Type Subtype PubMed ID
esv2747633 CNV Deletion 23290073
nsv826707 CNV Loss 20364138
esv2667348 CNV Deletion 23128226
esv2747634 CNV Deletion 23290073

Relevant External Links for MZT1 Gene

HapMap Linkage Disequilibrium report
MZT1

Disorders for MZT1 Gene

No disorders were found for MZT1 Gene.

No data available for UniProtKB/Swiss-Prot for MZT1 Gene

Publications for MZT1 Gene

  1. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 2 3 4
  2. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  3. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3
  4. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PMID: 22053931) Oshikawa K. … Nakayama K.I. (J. Proteome Res. 2012) 3
  5. The GCP3-interacting proteins GIP1 and GIP2 are required for I^-tubulin complex protein localization, spindle integrity, and chromosomal stability. (PMID: 22427335) Janski N. … Schmit A.C. (Plant Cell 2012) 3

Products for MZT1 Gene

Sources for MZT1 Gene

Back to Top

Content