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MZF1 Gene

protein-coding   GIFtS: 48
GCID: GC19M059073

Myeloid Zinc Finger 1

(Previous name: zinc finger protein 42 (myeloid-specific retinoic acid-responsive))
(Previous symbol: ZNF42)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myeloid Zinc Finger 11 2     ZSCAN62 3
ZNF421 2 3 5     MZF1B2
Zinc Finger Protein 42 (Myeloid-Specific Retinoic Acid-Responsive)1 2     ZFP982
Zinc Finger And SCAN Domain-Containing Protein 62 3     MZF3
MZF-12 3     Zinc Finger Protein 423

External Ids:    HGNC: 131081   Entrez Gene: 75932   Ensembl: ENSG000000993267   OMIM: 1945505   UniProtKB: P286983   

Export aliases for MZF1 gene to outside databases

Previous GC identifers: GC19M063766 GC19M055383


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MZF1 Gene:
MZF1 (myeloid zinc finger 1) is a protein-coding gene. Diseases associated with MZF1 include transitional cell carcinoma, and bladder transitional cell carcinoma. GO annotations related to this gene include transcription regulatory region DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZSCAN10.

UniProtKB/Swiss-Prot: MZF1_HUMAN, P28698
Function: Binds to target promoter DNA and functions as trancription regulator. Regulates transcription from the
PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development

Gene Wiki entry for MZF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MZF1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMZF1 promoter sequence
   Search Chromatin IP Primers for MZF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MZF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

MZF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MZF1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M059073:  view genomic region     (about GC identifiers)

Start:
59,073,284 bp from pter      End:
59,084,942 bp from pter
Size:
11,659 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MZF1_HUMAN, P28698 (See protein sequence)
Recommended Name: Myeloid zinc finger 1  
Size: 734 amino acids; 82055 Da
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for MZF1:
2FI2 (3D)    
Secondary accessions: M0QXU0 Q7Z729 Q96I71 Q9NRY0 Q9UBW2
Alternative splicing: 3 isoforms:  P28698-1   P28698-2   P28698-3   

Explore the universe of human proteins at neXtProt for MZF1: NX_P28698

Explore proteomics data for MZF1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MZF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001253962.1  NP_003413.2  NP_932172.1  

    ENSEMBL proteins: 
     ENSP00000469378   ENSP00000215057   ENSP00000469493   ENSP00000472123   ENSP00000472454  

    MZF1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for MZF1
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    Novus Biologicals MZF1 Proteins
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for MZF1

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    ThermoFisher Antibodies for MZF1
    LSBio Antibodies in human, mouse, rat for MZF1

    MZF1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for MZF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR008916 Retrov_capsid_C
     IPR003309 Tscrpt_reg_SCAN
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P28698

    ProtoNet protein and cluster: P28698

    2 Blocks protein domains:
    IPB003309 Transcriptional regulator SCAN
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: MZF1_HUMAN, P28698
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 SCAN box domain


    MZF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MZF1_HUMAN, P28698
    Function: Binds to target promoter DNA and functions as trancription regulator. Regulates transcription from the
    PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development
    Induction: By retinoic acid

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI10777584
    GO:0042803protein homodimerization activity IPI16950398
    GO:0044212transcription regulatory region DNA binding IDA15541732
    GO:0046872metal ion binding IEA--
         
    MZF1 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mzf1):
     hematopoietic system  immune system  mortality/aging  skeleton  tumorigenesis 

    MZF1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mzf1tm1Ppp for MZF1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MZF1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MZF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MZF1

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for MZF1 (see all 518):
    AANAT,  AARS,  ABCC6P1,  ABCC6P2,  ABHD14A,  ACADS,  ACRBP,  ACY1,  ADAMTS18,  ADCY6

    miRNA
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    OriGene RNAi products in human, mouse, rat for MZF1
    Predesigned siRNA for gene silencing in human, mouse, rat MZF1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MZF1

    Clone
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    OriGene clones in human, mouse for MZF1 (see all 15)
    OriGene ORF clones in mouse, rat for MZF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MZF1 (NM_003422)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MZF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MZF1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MZF1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MZF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MZF1_HUMAN, P28698: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    MZF1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MZF1
    Interactions:

        GeneGlobe Interaction Network for MZF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for MZF1 (P286983 ENSP000002150574) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCAND1P570863, ENSP000003019954I2D: score=1 STRING: ENSP00000301995
    FHL3Q136433, ENSP000003621074I2D: score=2 STRING: ENSP00000362107
    LDOC1O957513, ENSP000003595574I2D: score=3 STRING: ENSP00000359557
    NFYCQ139523I2D: score=1 
    CDK4ENSP000002579044STRING: ENSP00000257904
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IDA15541732

    MZF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MZF1

    3 Novoseek inferred chemical compound relationships for MZF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 67.7 33 8114711 (3), 9593266 (2), 18472161 (2), 9413999 (2) (see all 19)
    retinoic acid 33.4 4 9593266 (2), 1860835 (1), 8845378 (1)
    oligonucleotide 5.64 2 16297876 (1), 17593797 (1)



    MZF1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MZF1 gene (3 alternative transcripts): 
    NM_001267033.1  NM_003422.2  NM_198055.1  

    Unigene Cluster for MZF1:

    Myeloid zinc finger 1
    Hs.399810  [show with all ESTs]
    Unigene Representative Sequence: NM_198055
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600004 ENST00000594234 ENST00000215057(uc002qto.3 uc002qtn.3 uc010euu.1)
    ENST00000599369 ENST00000595245 ENST00000594108 ENST00000600048 ENST00000596039

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MZF1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MZF1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MZF1
    Predesigned siRNA for gene silencing in human, mouse, rat MZF1
    Clone
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    OriGene clones in human, mouse for MZF1 (see all 15)
    OriGene ORF clones in mouse, rat for MZF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MZF1 (NM_003422)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MZF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MZF1
    Primer
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    OriGene qPCR primer pairs and template standards for MZF1
    OriGene qSTAR qPCR primer pairs in human, mouse for MZF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MZF1
      QuantiTect SYBR Green Assays in human, mouse, rat MZF1
      QuantiFast Probe-based Assays in human, mouse, rat MZF1

    Additional mRNA sequence: 

    AF055077.1 AF055078.1 AK126582.1 AK308893.1 AK310381.1 BC007777.2 BC053316.1 

    14 DOTS entries:

    DT.85105644  DT.100785482  DT.97782183  DT.430762  DT.100782976  DT.100025658  DT.102840969  DT.97844588 
    DT.98083851  DT.95320581  DT.99932591  DT.91775282  DT.87015492  DT.87015493 

    Selected AceView cDNA sequences (see all 100):

    BX406549 BU727300 BQ186860 AF055078 BC053316 CA944862 BQ187788 BU616192 
    BU619432 BI439043 BQ003429 BM665326 CK430629 AF055077 BC007777 NM_198055 
    CB050693 BM692648 AJ713400 NM_003422 AI660726 BG928271 AJ573559 BM931603 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MZF1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                    -     -     -     -                             -                                       
    SP2:                                -     -                             -                                       
    SP3:                                -     -                             -                             -         
    SP4:                                -                                                                           
    SP5:              -     -     -     -     -                                                                     


    ECgene alternative splicing isoforms for MZF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MZF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCAGAACAC
    MZF1 Expression
    About this image


    MZF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    MZF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MZF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.399810

    UniProtKB/Swiss-Prot: MZF1_HUMAN, P28698
    Tissue specificity: Preferentially expressed in differentiating myeloid cells. Detected in osteoblasts

        Custom PCR Arrays for MZF1
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    QuantiFast Probe-based Assays in human, mouse, rat MZF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MZF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MZF1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mzf11 , 5 myeloid zinc finger 11, 5 82.76(n)1
    83.08(a)1
      7 (7.73 cM)5
    1098891  NM_145819.21  NP_665818.21 
     130423035 
    African clawed frog
    (Xenopus laevis)
    Amphibia BG486944.12   -- 89.2(n)    BG486944.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC064665.12   -- 72.89(n)   393876  BC064665.1 


    ENSEMBL Gene Tree for MZF1 (if available)
    TreeFam Gene Tree for MZF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MZF1 gene
    ZSCAN102  
    Selected SIMAP similar genes for MZF1 using alignment to 3 protein entries:     MZF1_HUMAN (see all proteins) (see all similar genes):
    ZNF197    ZSCAN31    ZNF    ZNF501    ZNF589    ZNF132
    ZNF135    ZNF211    ZNF84    PRMD9    ZNF271    ZNF304
    ZNF32    ZNF446    ZNF500    ZNF623    ZNF696    ZNF697

    MZF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    5 SNPs for MZF1    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22292551,2,4
    ----see VAR_0476802 mis40--------
    rs37521101,2,4
    ----see VAR_0476782 mis40--------
    rs37521111,2,4
    ----see VAR_0476792 mis40--------
    rs47561,2,4
    ----see VAR_0148262 mis40--------
    rs37521091,2,4
    ----see VAR_0476772 mis40--------

    HapMap Linkage Disequilibrium report for MZF1 (59073284 - 59084942 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MZF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4032n71CNV Loss21882294
    nsv912546CNV Loss21882294
    nsv828657CNV Gain20364138
    nsv515731CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MZF1
    DNA2.0 Custom Variant and Variant Library Synthesis for MZF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 194550    OMIM disorders: --

    10 diseases for MZF1:    
    About MalaCards
    transitional cell carcinoma    bladder transitional cell carcinoma    polycystic kidney disease    kidney disease
    myeloid leukemia    hepatocellular carcinoma    cervical cancer    leukemia
    cervicitis    breast cancer


    MZF1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for MZF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 38.4 1 9593266 (1)
    leukemia 0 3 8845378 (1)
    tumors 0 4 20145042 (2), 16950398 (1)


    Export disorders for MZF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MZF1 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with MZF1)
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    1. A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. (PubMed id 1860835)1, 2, 3, 9 Hromas R.... Kaushansky K. (J. Biol. Chem. 1991)
    2. Crucial roles of MZF1 and Sp1 in the transcriptional regulation of the peptidylarginine deiminase type I gene (PADI1) in human keratinocytes. (PubMed id 17851584)1, 2, 9 Dong S.... Takahara H. (J. Invest. Dermatol. 2008)
    3. Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N- cadherin promoter in osteoblasts. (PubMed id 15541732)1, 2, 9 Le Mee S.... Marie P.J. (Exp. Cell Res. 2005)
    4. Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein. (PubMed id 10974541)1, 2, 9 Peterson M.J. and Morris J.F. (Gene 2000)
    5. Structure of the SCAN domain from the tumor suppressor protein MZF1. (PubMed id 16950398)1, 2, 9 Peterson F.C.... Volkman B.F. (J. Mol. Biol. 2006)
    6. Heterodimer formation of the myeloid zinc finger 1 SCAN domain and association with promyelocytic leukemia nuclear bodies. (PubMed id 18472161)1, 9 Noll L....Sander T. (Leuk. Res. 2008)
    7. Myeloid zinc finger 1 induces migration, invasion, and in vivo metastasis through Axl gene expression in solid cancer. (PubMed id 20145042)1, 9 Mudduluru G....Allgayer H. (Mol. Cancer Res. 2010)
    8. Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations. (PubMed id 10777584)1, 9 Sander T.L.... Morris J.F. (J. Biol. Chem. 2000)
    9. FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF- 1. (PubMed id 15453830)1, 9 Takahashi K.... Ra C. (Biochem. J. 2005)
    10. Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro. (PubMed id 1719120)1, 9 Bavisotto L....Hromas R. (J. Exp. Med. 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7593 HGNC: 13108 AceView: ZNF42 Ensembl:ENSG00000099326 euGenes: HUgn7593
    ECgene: MZF1 H-InvDB: MZF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MZF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MZF1 gene:
    Search GeneIP for patents involving MZF1

    GeneCards and IP:
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