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Aliases for MZF1 Gene

Aliases for MZF1 Gene

  • Myeloid Zinc Finger 1 2 3
  • Zinc Finger Protein 42 (Myeloid-Specific Retinoic Acid-Responsive) 2 3
  • Zinc Finger And SCAN Domain-Containing Protein 6 3 4
  • ZSCAN6 3 4
  • MZF-1 3 4
  • ZNF42 3 4
  • Zinc Finger Protein 42 4
  • ZNF42, 6
  • MZF1B 3
  • ZFP98 3
  • MZF 4

External Ids for MZF1 Gene

Previous HGNC Symbols for MZF1 Gene

  • ZNF42

Previous GeneCards Identifiers for MZF1 Gene

  • GC19M063766
  • GC19M059073
  • GC19M055383

Summaries for MZF1 Gene

GeneCards Summary for MZF1 Gene

MZF1 (Myeloid Zinc Finger 1) is a Protein Coding gene. Diseases associated with MZF1 include transitional cell carcinoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is ZSCAN10.

UniProtKB/Swiss-Prot for MZF1 Gene

  • Binds to target promoter DNA and functions as trancription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development.

Gene Wiki entry for MZF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MZF1 Gene

Genomics for MZF1 Gene

Regulatory Elements for MZF1 Gene

Transcription factor binding sites by QIAGEN in the MZF1 gene promoter:

Genomic Location for MZF1 Gene

Start:
58,561,917 bp from pter
End:
58,573,760 bp from pter
Size:
11,844 bases
Orientation:
Minus strand

Genomic View for MZF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MZF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MZF1 Gene

Proteins for MZF1 Gene

  • Protein details for MZF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28698-MZF1_HUMAN
    Recommended name:
    Myeloid zinc finger 1
    Protein Accession:
    P28698
    Secondary Accessions:
    • M0QXU0
    • Q7Z729
    • Q96I71
    • Q9NRY0
    • Q9UBW2

    Protein attributes for MZF1 Gene

    Size:
    734 amino acids
    Molecular mass:
    82055 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for MZF1 Gene

    Alternative splice isoforms for MZF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MZF1 Gene

Proteomics data for MZF1 Gene at MOPED

Post-translational modifications for MZF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MZF1 Gene

No data available for DME Specific Peptides for MZF1 Gene

Domains for MZF1 Gene

Gene Families for MZF1 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for MZF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28698

UniProtKB/Swiss-Prot:

MZF1_HUMAN :
  • P28698
Domain:
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with MZF1: view

Function for MZF1 Gene

Molecular function for MZF1 Gene

UniProtKB/Swiss-Prot Function: Binds to target promoter DNA and functions as trancription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development.
UniProtKB/Swiss-Prot Induction: By retinoic acid

Gene Ontology (GO) - Molecular Function for MZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 7579328
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 7579328
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 7579328
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 1860835
GO:0005515 protein binding IPI 10777584
genes like me logo Genes that share ontologies with MZF1: view
genes like me logo Genes that share phenotypes with MZF1: view

Animal Models for MZF1 Gene

MGI Knock Outs for MZF1:

Transcription Factor Targeting for MZF1 Gene

Selected GeneGlobe predicted Target genes for MZF1

No data available for Enzyme Numbers (IUBMB) , miRNA and HOMER Transcription for MZF1 Gene

Localization for MZF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MZF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MZF1 Gene COMPARTMENTS Subcellular localization image for MZF1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for MZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with MZF1: view

Pathways for MZF1 Gene

SuperPathways for MZF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 7579328
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 15541732
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 7579328
genes like me logo Genes that share ontologies with MZF1: view

No data available for Pathways by source for MZF1 Gene

Compounds for MZF1 Gene

(3) Novoseek inferred chemical compound relationships for MZF1 Gene

Compound -log(P) Hits PubMed IDs
zinc 67.7 27
retinoic acid 33.4 4
oligonucleotide 5.64 2
genes like me logo Genes that share compounds with MZF1: view

Transcripts for MZF1 Gene

Unigene Clusters for MZF1 Gene

Myeloid zinc finger 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MZF1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5: - - - - -
SP6:
SP7:

Relevant External Links for MZF1 Gene

GeneLoc Exon Structure for
MZF1
ECgene alternative splicing isoforms for
MZF1

Expression for MZF1 Gene

mRNA expression in normal human tissues for MZF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for MZF1 Gene Hs.399810

mRNA Expression by UniProt/SwissProt for MZF1 Gene

P28698-MZF1_HUMAN
Tissue specificity: Preferentially expressed in differentiating myeloid cells. Detected in osteoblasts.
genes like me logo Genes that share expressions with MZF1: view

No data available for mRNA differential expression in normal tissues and Protein expression for MZF1 Gene

Orthologs for MZF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MZF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MZF1 35
  • 97.27 (n)
  • 96.4 (a)
MZF1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MZF1 35
  • 83.42 (n)
  • 82.65 (a)
MZF1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MZF1 35
  • 82.15 (n)
  • 84.88 (a)
MZF1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mzf1 35
  • 82.76 (n)
  • 83.08 (a)
Mzf1 16
Mzf1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 36 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mzf1 35
  • 82.76 (n)
  • 83.22 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
Species with no ortholog for MZF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MZF1 Gene

ENSEMBL:
Gene Tree for MZF1 (if available)
TreeFam:
Gene Tree for MZF1 (if available)

Paralogs for MZF1 Gene

Paralogs for MZF1 Gene

Selected SIMAP similar genes for MZF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MZF1: view

Variants for MZF1 Gene

Sequence variations from dbSNP and Humsavar for MZF1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_014826 -
VAR_047677 -
VAR_047678 -
VAR_047679 -
VAR_047680 -

Structural Variations from Database of Genomic Variants (DGV) for MZF1 Gene

Variant ID Type Subtype PubMed ID
nsv515731 CNV Gain+Loss 19592680
nsv828657 CNV Gain 20364138
nsv912546 CNV Loss 21882294
dgv4032n71 CNV Loss 21882294

Relevant External Links for MZF1 Gene

HapMap Linkage Disequilibrium report
MZF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MZF1 Gene

Disorders for MZF1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MZF1 Gene including...

Search for MZF1 Gene in MalaCards »

(3) Novoseek inferred disease relationships for MZF1 Gene

Disease -log(P) Hits PubMed IDs
myeloid leukemia 38.4 1
leukemia 0 1
tumors 0 3
genes like me logo Genes that share disorders with MZF1: view

No data available for UniProtKB/Swiss-Prot for MZF1 Gene

Publications for MZF1 Gene

  1. A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. (PMID: 1860835) Hromas R. … Kaushansky K. (J. Biol. Chem. 1991) 2 3 4 23
  2. Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein. (PMID: 10974541) Peterson M.J. … Morris J.F. (Gene 2000) 3 4 23
  3. Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N- cadherin promoter in osteoblasts. (PMID: 15541732) Le Mee S. … Marie P.J. (Exp. Cell Res. 2005) 3 4 23
  4. Structure of the SCAN domain from the tumor suppressor protein MZF1. (PMID: 16950398) Peterson F.C. … Volkman B.F. (J. Mol. Biol. 2006) 3 4 23
  5. Crucial roles of MZF1 and Sp1 in the transcriptional regulation of the peptidylarginine deiminase type I gene (PADI1) in human keratinocytes. (PMID: 17851584) Dong S. … Takahara H. (J. Invest. Dermatol. 2008) 3 4 23

Products for MZF1 Gene

Sources for MZF1 Gene

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