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Aliases for MZF1 Gene

Aliases for MZF1 Gene

  • Myeloid Zinc Finger 1 2 3 5
  • Zinc Finger Protein 42 (Myeloid-Specific Retinoic Acid-Responsive) 2 3
  • Zinc Finger And SCAN Domain-Containing Protein 6 3 4
  • ZSCAN6 3 4
  • ZNF42 3 4
  • MZF-1 3 4
  • Zinc Finger Protein 42 4
  • MZF1B 3
  • ZFP98 3
  • MZF 4

External Ids for MZF1 Gene

Previous HGNC Symbols for MZF1 Gene

  • ZNF42

Previous GeneCards Identifiers for MZF1 Gene

  • GC19M063766
  • GC19M059073
  • GC19M055383

Summaries for MZF1 Gene

GeneCards Summary for MZF1 Gene

MZF1 (Myeloid Zinc Finger 1) is a Protein Coding gene. Diseases associated with MZF1 include Arrhythmogenic Right Ventricular Dysplasia 1. Among its related pathways are Ectoderm Differentiation. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ZSCAN10.

UniProtKB/Swiss-Prot for MZF1 Gene

  • Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development.

Gene Wiki entry for MZF1 Gene

Additional gene information for MZF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MZF1 Gene

Genomics for MZF1 Gene

Regulatory Elements for MZF1 Gene

Enhancers for MZF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H058553 1.4 ENCODE dbSUPER 45.2 +17.3 17327 7 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A ZFP41 MEF2D TRIM28 ZNF606 MZF1 LOC100128398 ERVK3-1 ZNF134 ZNF417 ZNF329 ZNF324B ZNF418
GH19H058517 2 FANTOM5 Ensembl ENCODE dbSUPER 31.1 +54.7 54731 4 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZNF324B ZNF446 TRIM28 ZNF134 ZNF549 ZNF417 ZNF606 ZNF135 MZF1 ZNF274
GH19H058181 1.1 ENCODE 48.2 +391.2 391203 2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 CBX5 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF773 ZNF550 ZNF543 ZNF256 LOC105372483
GH19H058325 1.2 ENCODE 39.2 +247.6 247569 3 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZFP41 ZNF134 ZNF606 ZNF549 ZNF446 ZNF17 ZNF135 ZNF417 ZNF324B TRIM28 LOC100128398
GH19H058379 1.2 ENCODE 27.8 +193.4 193354 2 ZFP64 FEZF1 DMAP1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A ZFP41 ZNF610 LOC100128398 ZNF329 ZNF606 ZSCAN18 ZNF135 TRIM28 ZNF446 ZNF132 ZNF549 ZNF417
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MZF1 on UCSC Golden Path with GeneCards custom track

Promoters for MZF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000289366 1239 1201 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1
ENSR00000111894 -1261 1800 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Transcription factor binding sites by QIAGEN in the MZF1 gene promoter:

Genomic Location for MZF1 Gene

Chromosome:
19
Start:
58,561,917 bp from pter
End:
58,574,439 bp from pter
Size:
12,523 bases
Orientation:
Minus strand

Genomic View for MZF1 Gene

Genes around MZF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MZF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MZF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MZF1 Gene

Proteins for MZF1 Gene

  • Protein details for MZF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28698-MZF1_HUMAN
    Recommended name:
    Myeloid zinc finger 1
    Protein Accession:
    P28698
    Secondary Accessions:
    • M0QXU0
    • Q7Z729
    • Q96I71
    • Q9NRY0
    • Q9UBW2

    Protein attributes for MZF1 Gene

    Size:
    734 amino acids
    Molecular mass:
    82055 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for MZF1 Gene

    Alternative splice isoforms for MZF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MZF1 Gene

Post-translational modifications for MZF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MZF1 Gene

Domains & Families for MZF1 Gene

Gene Families for MZF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for MZF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28698

UniProtKB/Swiss-Prot:

MZF1_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with MZF1: view

Function for MZF1 Gene

Molecular function for MZF1 Gene

UniProtKB/Swiss-Prot Function:
Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development.
UniProtKB/Swiss-Prot Induction:
By retinoic acid.

Phenotypes From GWAS Catalog for MZF1 Gene

Gene Ontology (GO) - Molecular Function for MZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 7579328
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 7579328
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 7579328
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with MZF1: view
genes like me logo Genes that share phenotypes with MZF1: view

Animal Models for MZF1 Gene

MGI Knock Outs for MZF1:

Animal Model Products

CRISPR Products

Transcription Factor Targets for MZF1 Gene

Selected GeneGlobe predicted Target genes for MZF1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MZF1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA and HOMER Transcription for MZF1 Gene

Localization for MZF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MZF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MZF1 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA --
genes like me logo Genes that share ontologies with MZF1: view

Pathways & Interactions for MZF1 Gene

SuperPathway Contained pathways
1 Ectoderm Differentiation
genes like me logo Genes that share pathways with MZF1: view

Pathways by source for MZF1 Gene

1 BioSystems pathway for MZF1 Gene

Gene Ontology (GO) - Biological Process for MZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 7579328
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IDA 15541732
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 7579328
genes like me logo Genes that share ontologies with MZF1: view

No data available for SIGNOR curated interactions for MZF1 Gene

Drugs & Compounds for MZF1 Gene

(1) Drugs for MZF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MZF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MZF1: view

Transcripts for MZF1 Gene

Unigene Clusters for MZF1 Gene

Myeloid zinc finger 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MZF1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MZF1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5: - - - - -
SP6:
SP7:

Relevant External Links for MZF1 Gene

GeneLoc Exon Structure for
MZF1
ECgene alternative splicing isoforms for
MZF1

Expression for MZF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MZF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of MZF1 Gene:

MZF1

SOURCE GeneReport for Unigene cluster for MZF1 Gene:

Hs.399810

mRNA Expression by UniProt/SwissProt for MZF1 Gene:

P28698-MZF1_HUMAN
Tissue specificity: Preferentially expressed in differentiating myeloid cells. Detected in osteoblasts.

Evidence on tissue expression from TISSUES for MZF1 Gene

  • Bone marrow(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with MZF1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MZF1 Gene

Orthologs for MZF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MZF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MZF1 33 34
  • 97.27 (n)
cow
(Bos Taurus)
Mammalia MZF1 33 34
  • 83.42 (n)
mouse
(Mus musculus)
Mammalia Mzf1 33 16 34
  • 82.76 (n)
rat
(Rattus norvegicus)
Mammalia Mzf1 33
  • 82.76 (n)
dog
(Canis familiaris)
Mammalia MZF1 33 34
  • 82.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii -- 33
Species where no ortholog for MZF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MZF1 Gene

ENSEMBL:
Gene Tree for MZF1 (if available)
TreeFam:
Gene Tree for MZF1 (if available)

Paralogs for MZF1 Gene

Paralogs for MZF1 Gene

(365) SIMAP similar genes for MZF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MZF1: view

Variants for MZF1 Gene

Sequence variations from dbSNP and Humsavar for MZF1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000070536 -- 58,562,848(+) CGCAC(C/T)AGGAG intron-variant, reference, missense, utr-variant-3-prime
rs1000370971 -- 58,568,054(+) CAACA(C/T)AGTGA intron-variant
rs1000873365 -- 58,562,380(+) GAAGC(A/C)CAGGC intron-variant, reference, missense, utr-variant-3-prime
rs1000967146 -- 58,568,301(+) AGATA(C/T)AAGTG intron-variant
rs1000998235 -- 58,567,928(+) ACACT(C/G/T)TTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MZF1 Gene

Variant ID Type Subtype PubMed ID
dgv3687n100 CNV gain 25217958
dgv3688n100 CNV gain 25217958
nsv1057077 CNV gain 25217958
nsv1057206 CNV gain 25217958
nsv1114041 CNV deletion 24896259
nsv1160670 CNV deletion 26073780
nsv515731 CNV gain+loss 19592680
nsv828657 CNV gain 20364138
nsv952156 CNV deletion 24416366

Variation tolerance for MZF1 Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.55; 93.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MZF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MZF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MZF1 Gene

Disorders for MZF1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MZF1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
arrhythmogenic right ventricular dysplasia 1
  • arrhythmogenic right ventricular cardiomyopathy 1
- elite association - COSMIC cancer census association via MalaCards
Search MZF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MZF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MZF1
genes like me logo Genes that share disorders with MZF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MZF1 Gene

Publications for MZF1 Gene

  1. A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. (PMID: 1860835) Hromas R … Kaushansky K (The Journal of biological chemistry 1991) 2 3 4 22 60
  2. Crucial roles of MZF1 and Sp1 in the transcriptional regulation of the peptidylarginine deiminase type I gene (PADI1) in human keratinocytes. (PMID: 17851584) Dong S … Takahara H (The Journal of investigative dermatology 2008) 3 4 22 60
  3. Structure of the SCAN domain from the tumor suppressor protein MZF1. (PMID: 16950398) Peterson FC … Volkman BF (Journal of molecular biology 2006) 3 4 22 60
  4. Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts. (PMID: 15541732) Le Mée S … Marie PJ (Experimental cell research 2005) 3 4 22 60
  5. Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein. (PMID: 10974541) Peterson MJ … Morris JF (Gene 2000) 3 4 22 60

Products for MZF1 Gene

Sources for MZF1 Gene

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