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Aliases for MZB1 Gene

Aliases for MZB1 Gene

  • Marginal Zone B And B1 Cell-Specific Protein 2 3
  • PACAP 3 4 6
  • Plasma Cell-Induced Resident Endoplasmic Reticulum Protein 3 4
  • Mesenteric Oestrogen-Dependent Adipose Gene- 7 2 3
  • Mesenteric Estrogen-Dependent Adipose 7 3 4
  • Plasma Cell-Induced Resident ER Protein 3 4
  • Proapoptotic Caspase Adaptor Protein 2 3
  • Proapoptotic Caspase Adapter Protein 3 4
  • Plasma Cell-Induced ER Protein 1 2 3
  • MEDA-7 3 4
  • PERp1 3 4
  • Marginal Zone B- And B1-Cell-Specific Protein 3
  • Caspase-2 Binding Protein 3
  • MGC29506 6
  • HSPC190 3
  • MEDA7 4

External Ids for MZB1 Gene

Summaries for MZB1 Gene

GeneCards Summary for MZB1 Gene

MZB1 (Marginal Zone B And B1 Cell-Specific Protein) is a Protein Coding gene. Among its related pathways are IL-2 Pathway.

UniProtKB/Swiss-Prot for MZB1 Gene

  • Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.

  • Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MZB1 Gene

Genomics for MZB1 Gene

Genomic Location for MZB1 Gene

Start:
139,387,480 bp from pter
End:
139,390,081 bp from pter
Size:
2,602 bases
Orientation:
Minus strand

Genomic View for MZB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MZB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MZB1 Gene

No data available for Regulatory Elements for MZB1 Gene

Proteins for MZB1 Gene

  • Protein details for MZB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WU39-MZB1_HUMAN
    Recommended name:
    Marginal zone B- and B1-cell-specific protein
    Protein Accession:
    Q8WU39
    Secondary Accessions:
    • D2IYS0
    • Q7Z6N2
    • Q96RL5
    • Q9P0T3

    Protein attributes for MZB1 Gene

    Size:
    189 amino acids
    Molecular mass:
    20694 Da
    Quaternary structure:
    • Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains (By similarity). Isoform 2 interacts with CASP2 and CASP9. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner (By similarity).
    SequenceCaution:
    • Sequence=AAF36110.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for MZB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MZB1 Gene

Proteomics data for MZB1 Gene at MOPED

Post-translational modifications for MZB1 Gene

Other Protein References for MZB1 Gene

No data available for DME Specific Peptides for MZB1 Gene

Domains for MZB1 Gene

Protein Domains for MZB1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MZB1_HUMAN
Family:
  • Belongs to the MZB1 family.:
    • Q8WU39
genes like me logo Genes that share domains with MZB1: view

No data available for Gene Families for MZB1 Gene

Function for MZB1 Gene

Molecular function for MZB1 Gene

UniProtKB/Swiss-Prot Function: Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.
UniProtKB/Swiss-Prot Function: Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance
UniProtKB/Swiss-Prot Induction: Down-regulated in primary B-cells early after ligand-stimulated activation. Up-regulated in bacterial lipopolysaccharides (LPS)-stimulated peritoneal macrophages.

Gene Ontology (GO) - Molecular Function for MZB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11350957
genes like me logo Genes that share ontologies with MZB1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MZB1 Gene

Localization for MZB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MZB1 Gene

Isoform 1: Endoplasmic reticulum lumen. Secreted.
Isoform 2: Cytoplasm. Note=Diffuse granular localization in the cytoplasm surrounding the nucleus.

Gene Ontology (GO) - Cellular Components for MZB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IDA 11350957
GO:0005788 endoplasmic reticulum lumen ISS --
GO:0034663 endoplasmic reticulum chaperone complex ISS --
genes like me logo Genes that share ontologies with MZB1: view

Pathways for MZB1 Gene

SuperPathways for MZB1 Gene

Superpath Contained pathways
1 IL-2 Pathway
genes like me logo Genes that share pathways with MZB1: view

Pathways by source for MZB1 Gene

1 Qiagen pathway for MZB1 Gene

Gene Ontology (GO) - Biological Process for MZB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002642 positive regulation of immunoglobulin biosynthetic process ISS --
GO:0006915 apoptotic process IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0030888 regulation of B cell proliferation ISS --
GO:0033622 integrin activation ISS --
genes like me logo Genes that share ontologies with MZB1: view

Transcripts for MZB1 Gene

Unigene Clusters for MZB1 Gene

Marginal zone B and B1 cell-specific protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MZB1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - - -
SP5:
SP6:

Relevant External Links for MZB1 Gene

GeneLoc Exon Structure for
MZB1
ECgene alternative splicing isoforms for
MZB1

Expression for MZB1 Gene

mRNA expression in normal human tissues for MZB1 Gene

mRNA differential expression in normal tissues according to GTEx for MZB1 Gene

This gene is overexpressed in Spleen (15.8), Colon - Transverse (4.3), and Minor Salivary Gland (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MZB1 Gene

SOURCE GeneReport for Unigene cluster for MZB1 Gene Hs.409563

mRNA Expression by UniProt/SwissProt for MZB1 Gene

Q8WU39-MZB1_HUMAN
Tissue specificity: Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat.
genes like me logo Genes that share expressions with MZB1: view

Orthologs for MZB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MZB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MZB1 36
  • 99.47 (n)
  • 99.47 (a)
MZB1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MZB1 36
  • 81.83 (n)
  • 78.31 (a)
MZB1 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MZB1 36
  • 87.65 (n)
  • 85.71 (a)
MZB1 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mzb1 36
  • 77.59 (n)
  • 71.19 (a)
Mzb1 16
Mzb1 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MZB1 37
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mzb1 36
  • 78.15 (n)
  • 72.32 (a)
chicken
(Gallus gallus)
Aves LOC100859189 36
  • 59.1 (n)
  • 49.65 (a)
MZB1 37
  • 41 (a)
OneToOne
Species with no ortholog for MZB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MZB1 Gene

ENSEMBL:
Gene Tree for MZB1 (if available)
TreeFam:
Gene Tree for MZB1 (if available)

Paralogs for MZB1 Gene

No data available for Paralogs for MZB1 Gene

Variants for MZB1 Gene

Sequence variations from dbSNP and Humsavar for MZB1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs6866707 -- 139,390,631(+) TTATT(A/T)CACAC upstream-variant-2KB
rs9327846 -- 139,388,768(+) TGGGG(A/G)TGGGG intron-variant
rs9327847 -- 139,388,862(+) TCATT(C/T)TATTT intron-variant
rs33937093 -- 139,388,438(+) GAGGT(-/G)GGGGG intron-variant
rs55633667 -- 139,390,086(+) CAGAT(-/GAT)AGGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MZB1 Gene

Variant ID Type Subtype PubMed ID
esv28262 CNV Gain 19812545
nsv482090 CNV Gain 20164927

Relevant External Links for MZB1 Gene

HapMap Linkage Disequilibrium report
MZB1

Disorders for MZB1 Gene

No disorders were found for MZB1 Gene.

No data available for UniProtKB/Swiss-Prot for MZB1 Gene

Publications for MZB1 Gene

  1. Characterization of a novel proapoptotic caspase-2- and caspase-9- binding protein. (PMID: 11350957) Bonfoco E. … Cooper N.R. (J. Biol. Chem. 2001) 2 3 4 23
  2. MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, encodes secreted-type protein with conserved cysteine residues. (PMID: 12792799) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 3 4 23
  3. Novel hormone-regulated genes in visceral adipose tissue: cloning and identification of proinflammatory cytokine-like mouse and human MEDA- 7: implications for obesity, insulin resistance and the metabolic syndrome. (PMID: 21688198) Zhang H. … Sairam M.R. (Diabetologia 2011) 2 3 4
  4. pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin. (PMID: 19805157) Shimizu Y. … Hendershot L.M. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4
  5. Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells. (PMID: 21093319) Flach H. … Grosschedl R. (Immunity 2010) 2 3

Products for MZB1 Gene

Sources for MZB1 Gene

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