Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MYZAP Gene

Aliases for MYZAP Gene

  • Myocardial Zonula Adherens Protein 2 3
  • MYOZAP 3 4 6
  • GUP 3 4 6
  • Myocardium-Enriched Zonula Adherens Protein 2 3
  • GRINL1A Upstream Protein 3 4
  • GCOM1 3 6
  • Myocardium-Enriched Zonula Occludens-1-Associated Protein 3
  • Myocardium-Enriched ZO1-Associated Protein 3
  • Myocardial Intercalated Disc Protein 3
  • GRINL1A Complex Locus Upstream 3

External Ids for MYZAP Gene

Summaries for MYZAP Gene

Entrez Gene Summary for MYZAP Gene

  • This gene encodes a protein that is abundantly expressed in cardiac tissue. The encoded protein localizes to intercalated discs in cardiomyocytes and functions as an activator of Rho-dependent serum-response factor signaling. Alternative splicing results in multiple transcript variants. Readthrough transcription also exists between this gene and the neighboring downstream gene POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) and is represented with GeneID: 145781. [provided by RefSeq, Mar 2014]

GeneCards Summary for MYZAP Gene

MYZAP (Myocardial Zonula Adherens Protein) is a Protein Coding gene. An important paralog of this gene is POLR2M.

UniProtKB/Swiss-Prot for MYZAP Gene

  • Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYZAP Gene

Genomics for MYZAP Gene

Genomic Location for MYZAP Gene

Start:
57,591,904 bp from pter
End:
57,685,364 bp from pter
Size:
93,461 bases
Orientation:
Plus strand

Genomic View for MYZAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYZAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYZAP Gene

No data available for Regulatory Elements for MYZAP Gene

Proteins for MYZAP Gene

  • Protein details for MYZAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CAP1-MYZAP_HUMAN
    Recommended name:
    Myocardial zonula adherens protein
    Protein Accession:
    P0CAP1
    Secondary Accessions:
    • D2E9U7
    • Q6EER8
    • Q6EES2
    • Q6EEV3
    • Q6EF00
    • Q6EF01
    • Q6EF02
    • Q6EF46
    • Q6EFN8
    • Q6EM48
    • Q6K046
    • Q6K050
    • Q6K051
    • Q6ZQZ3
    • Q8NC58
    • Q8NCF3
    • Q96DI5
    • Q96JB7
    • Q96NF5

    Protein attributes for MYZAP Gene

    Size:
    466 amino acids
    Molecular mass:
    54206 Da
    Quaternary structure:
    • Interacts with DSP, MPRIP and TJP1/ZO1. Interaction with MPRIP inhibits the activation of transcription factor SRF (By similarity). Interacts with GRIN1. Interacts with DYNLL1.
    Miscellaneous:
    • The adjacent MYZAP and POLR2M genes are part of a complex transcription unit. The respective transcripts derive from different promoters and are alternatively spliced. In human, some transcripts of the upstream promoter of MYZAP use exons of the downstream POLR2M gene

    Three dimensional structures from OCA and Proteopedia for MYZAP Gene

    Alternative splice isoforms for MYZAP Gene

neXtProt entry for MYZAP Gene

Proteomics data for MYZAP Gene at MOPED

Post-translational modifications for MYZAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYZAP Gene

No data available for DME Specific Peptides for MYZAP Gene

Domains for MYZAP Gene

Protein Domains for MYZAP Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MYZAP_HUMAN
Family:
  • Belongs to the MYZAP family.:
    • P0CAP1
genes like me logo Genes that share domains with MYZAP: view

No data available for Gene Families for MYZAP Gene

Function for MYZAP Gene

Molecular function for MYZAP Gene

UniProtKB/Swiss-Prot Function: Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).

Gene Ontology (GO) - Molecular Function for MYZAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20412299
genes like me logo Genes that share ontologies with MYZAP: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MYZAP Gene

Localization for MYZAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYZAP Gene

Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, Z line. Cell junction. Note=Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin (By similarity). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for MYZAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030018 Z disc IEA --
GO:0030054 cell junction IEA --
GO:0030864 colocalizes_with cortical actin cytoskeleton ISS --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane ISS --
GO:0031674 I band ISS --
genes like me logo Genes that share ontologies with MYZAP: view

Pathways for MYZAP Gene

SuperPathways for MYZAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYZAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction ISS --
genes like me logo Genes that share ontologies with MYZAP: view

No data available for Pathways by source for MYZAP Gene

Transcripts for MYZAP Gene

mRNA/cDNA for MYZAP Gene

(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MYZAP Gene

No ASD Table

Relevant External Links for MYZAP Gene

GeneLoc Exon Structure for
MYZAP
ECgene alternative splicing isoforms for
MYZAP

Expression for MYZAP Gene

mRNA expression in normal human tissues for MYZAP Gene

mRNA differential expression in normal tissues according to GTEx for MYZAP Gene

This gene is overexpressed in Heart - Atrial Appendage (22.2), Heart - Left Ventricle (12.1), and Esophagus - Muscularis (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYZAP Gene

mRNA Expression by UniProt/SwissProt for MYZAP Gene

P0CAP1-MYZAP_HUMAN
Tissue specificity: Detected in heart, liver, skeletal muscle, placenta, small intestine, lung, prostate and testis.
genes like me logo Genes that share expressions with MYZAP: view

Orthologs for MYZAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYZAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GCOM1 36
  • 99.57 (n)
  • 99.57 (a)
cow
(Bos Taurus)
Mammalia MYZAP 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYZAP 36
  • 90.35 (n)
  • 92.01 (a)
MYZAP 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gcom1 37
  • 72 (a)
OneToMany
Myzap 36
  • 86.34 (n)
  • 89.91 (a)
Myzap 37
  • 90 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gcom1 36
  • 86.84 (n)
  • 90.56 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 38 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii polr2m 37
  • 29 (a)
OneToMany
Species with no ortholog for MYZAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYZAP Gene

ENSEMBL:
Gene Tree for MYZAP (if available)
TreeFam:
Gene Tree for MYZAP (if available)

Paralogs for MYZAP Gene

Paralogs for MYZAP Gene

Selected SIMAP similar genes for MYZAP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MYZAP: view

Variants for MYZAP Gene

Sequence variations from dbSNP and Humsavar for MYZAP Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
VAR_055453 -

Relevant External Links for MYZAP Gene

HapMap Linkage Disequilibrium report
MYZAP

No data available for Structural Variations from Database of Genomic Variants (DGV) for MYZAP Gene

Disorders for MYZAP Gene

No disorders were found for MYZAP Gene.

No data available for UniProtKB/Swiss-Prot for MYZAP Gene

Publications for MYZAP Gene

  1. Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo. (PMID: 20093627) Seeger T.S. … Frey N. (Circ. Res. 2010) 2 3 4
  2. Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A. (PMID: 20412299) Garcia-Mayoral M.F. … Bruix M. (FEBS J. 2010) 3 4
  3. Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration. (PMID: 21240187) Huo L. … Zhang M. (EMBO J. 2011) 3 4
  4. The plaque protein myozap identified as a novel major component of adhering junctions in endothelia of the blood and the lymph vascular systems. (PMID: 21992629) Pieperhoff S. … Franke W.W. (J. Cell. Mol. Med. 2012) 2 3
  5. Protein myozap--a late addition to the molecular ensembles of various kinds of adherens junctions. (PMID: 22160502) Rickelt S. … Franke W.W. (Cell Tissue Res. 2011) 2 3

Products for MYZAP Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MYZAP
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MYZAP
    • Block miRNA regulation of MYZAP using miScript Target Protectors

    Sources for MYZAP Gene

    Back to Top

    Content