Aliases for MYZAP Gene
External Ids for MYZAP Gene
Previous GeneCards Identifiers for MYZAP Gene
This gene encodes a protein that is abundantly expressed in cardiac tissue. The encoded protein localizes to intercalated discs in cardiomyocytes and functions as an activator of Rho-dependent serum-response factor signaling. Alternative splicing results in multiple transcript variants. Readthrough transcription also exists between this gene and the neighboring downstream gene POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) and is represented with GeneID: 145781. [provided by RefSeq, Mar 2014]
GeneCards Summary for MYZAP Gene
MYZAP (Myocardial Zonula Adherens Protein) is a Protein Coding gene. An important paralog of this gene is GCOM1.
UniProtKB/Swiss-Prot for MYZAP Gene
Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).