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Aliases for MYT1L Gene

Aliases for MYT1L Gene

  • Myelin Transcription Factor 1 Like 2 3
  • Neural Zinc Finger Transcription Factor 1 2 3
  • MyT1-L 3 4
  • Myelin Transcription Factor 1-Like 5
  • KIAA1106 4
  • ZC2HC4B 3
  • MRD39 3
  • MyT1L 4
  • NZF1 3

External Ids for MYT1L Gene

Previous GeneCards Identifiers for MYT1L Gene

  • GC02P002305
  • GC02P002420
  • GC02P002327

Summaries for MYT1L Gene

GeneCards Summary for MYT1L Gene

MYT1L (Myelin Transcription Factor 1 Like) is a Protein Coding gene. Diseases associated with MYT1L include mental retardation, autosomal dominant 39. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ST18.

UniProtKB/Swiss-Prot for MYT1L Gene

  • May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendroglia in the CNS (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYT1L Gene

Genomics for MYT1L Gene

Regulatory Elements for MYT1L Gene

Genomic Location for MYT1L Gene

1,789,113 bp from pter
2,331,375 bp from pter
542,263 bases
Minus strand

Genomic View for MYT1L Gene

Genes around MYT1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYT1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYT1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYT1L Gene

Proteins for MYT1L Gene

  • Protein details for MYT1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myelin transcription factor 1-like protein
    Protein Accession:
    Secondary Accessions:
    • A7E2C7
    • B2RP54
    • Q6IQ17
    • Q9UPP6

    Protein attributes for MYT1L Gene

    1186 amino acids
    Molecular mass:
    133043 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF14051.1; Type=Frameshift; Positions=1185; Evidence={ECO:0000305}; Sequence=BAA83058.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MYT1L Gene


neXtProt entry for MYT1L Gene

Proteomics data for MYT1L Gene at MOPED

Post-translational modifications for MYT1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYT1L Gene

No data available for DME Specific Peptides for MYT1L Gene

Domains & Families for MYT1L Gene

Gene Families for MYT1L Gene

Protein Domains for MYT1L Gene

Suggested Antigen Peptide Sequences for MYT1L Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 C2HC-type zinc fingers.
  • Contains 6 C2HC-type zinc fingers.
genes like me logo Genes that share domains with MYT1L: view

Function for MYT1L Gene

Molecular function for MYT1L Gene

UniProtKB/Swiss-Prot Function:
May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendroglia in the CNS (By similarity).
genes like me logo Genes that share phenotypes with MYT1L: view

Animal Models for MYT1L Gene

MGI Knock Outs for MYT1L:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYT1L Gene

Localization for MYT1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYT1L Gene

Subcellular locations from

Jensen Localization Image for MYT1L Gene COMPARTMENTS Subcellular localization image for MYT1L gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for MYT1L Gene

Pathways & Interactions for MYT1L Gene

SuperPathways for MYT1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYT1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with MYT1L: view

No data available for Pathways by source and SIGNOR curated interactions for MYT1L Gene

Drugs & Compounds for MYT1L Gene

No Compound Related Data Available

Transcripts for MYT1L Gene

Unigene Clusters for MYT1L Gene

Myelin transcription factor 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYT1L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
SP1: - - -
SP2: - -
SP4: - -

ExUns: 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b

Relevant External Links for MYT1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYT1L Gene

mRNA expression in normal human tissues for MYT1L Gene

mRNA differential expression in normal tissues according to GTEx for MYT1L Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.8), Brain - Anterior cingulate cortex (BA24) (x5.8), Brain - Putamen (basal ganglia) (x4.7), Brain - Cerebellar Hemisphere (x4.7), Brain - Nucleus accumbens (basal ganglia) (x4.6), Brain - Cortex (x4.4), and Brain - Caudate (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for MYT1L Gene

This gene is overexpressed in Plasma (40.0), Fetal gut (18.3), and Pancreatic juice (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYT1L Gene

SOURCE GeneReport for Unigene cluster for MYT1L Gene Hs.434418

genes like me logo Genes that share expression patterns with MYT1L: view

Protein tissue co-expression partners for MYT1L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MYT1L Gene

Orthologs for MYT1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYT1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MYT1L 35
  • 84.14 (n)
  • 90.8 (a)
MYT1L 36
  • 84 (a)
(Canis familiaris)
Mammalia MYT1L 35
  • 87.5 (n)
  • 94.18 (a)
MYT1L 36
  • 81 (a)
(Mus musculus)
Mammalia Myt1l 35
  • 89.16 (n)
  • 96.15 (a)
Myt1l 16
Myt1l 36
  • 94 (a)
(Pan troglodytes)
Mammalia MYT1L 35
  • 99.51 (n)
  • 100 (a)
MYT1L 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Myt1l 35
  • 87.94 (n)
  • 93.77 (a)
(Monodelphis domestica)
Mammalia MYT1L 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia MYT1L 36
  • 86 (a)
(Gallus gallus)
Aves MYT1L 35
  • 84.45 (n)
  • 95.26 (a)
MYT1L 36
  • 92 (a)
(Anolis carolinensis)
Reptilia MYT1L 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia myt1l 35
  • 78.64 (n)
  • 88.33 (a)
(Danio rerio)
Actinopterygii myt1la 35
  • 72.09 (n)
  • 76.05 (a)
MYT1L (1 of 2) 36
  • 62 (a)
myt1la 36
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43689 36
  • 11 (a)
(Caenorhabditis elegans)
Secernentea ztf-11 36
  • 18 (a)
(Triticum aestivum)
Liliopsida Ta.6362 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
Species with no ortholog for MYT1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MYT1L Gene

Gene Tree for MYT1L (if available)
Gene Tree for MYT1L (if available)

Paralogs for MYT1L Gene

Paralogs for MYT1L Gene

(3) SIMAP similar genes for MYT1L Gene using alignment to 4 proteins: Pseudogenes for MYT1L Gene

genes like me logo Genes that share paralogs with MYT1L: view

Variants for MYT1L Gene

Sequence variations from dbSNP and Humsavar for MYT1L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs756282 -- 2,062,905(-) agctg(A/C)aggat intron-variant
rs756283 -- 2,062,925(-) GAAGA(C/T)GATGG intron-variant
rs725311 -- 2,047,858(-) GTTTC(A/G)TATTT intron-variant
rs764465 -- 2,252,372(-) TGGAG(A/C)TGAGA intron-variant
rs736016 -- 2,112,722(+) CCAGG(A/G)GCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYT1L Gene

Variant ID Type Subtype PubMed ID
nsv873564 CNV Gain 21882294
nsv873570 CNV Loss 21882294
nsv470440 CNV Gain 18288195
nsv873571 CNV Loss 21882294
esv2719379 CNV Deletion 23290073
esv2719380 CNV Deletion 23290073
esv1354694 CNV Insertion 17803354
esv2719381 CNV Deletion 23290073
esv2719382 CNV Deletion 23290073
esv2719383 CNV Deletion 23290073
nsv215466 CNV Loss 16902084
nsv213819 CNV Loss 16902084
nsv508801 CNV Insertion 20534489
esv2719385 CNV Deletion 23290073
esv2719386 CNV Deletion 23290073
esv2719387 CNV Deletion 23290073
esv2719388 CNV Deletion 23290073
nsv433166 CNV Loss 18776910
dgv1139e1 CNV Complex 17122850
nsv833215 CNV Loss 17160897
esv2719389 CNV Deletion 23290073
esv2719390 CNV Deletion 23290073
esv1011603 CNV Deletion 17803354
esv2719391 CNV Deletion 23290073
esv2719392 CNV Deletion 23290073
nsv9280 CNV Gain 18304495
esv2719393 CNV Deletion 23290073
esv2661946 CNV Deletion 23128226
esv999007 CNV Deletion 20482838
esv1336055 CNV Deletion 17803354
nsv833226 CNV Loss 17160897
esv2719394 CNV Deletion 23290073
dgv673e199 CNV Deletion 23128226
esv26151 CNV Loss 19812545
esv2662310 CNV Deletion 23128226
esv2045899 CNV Deletion 18987734
nsv2571 CNV Insertion 18451855
esv26557 CNV Gain+Loss 19812545
esv2719396 CNV Deletion 23290073
esv2498228 CNV Deletion 19546169
nsv820484 CNV Deletion 20802225
esv2719397 CNV Deletion 23290073
esv1004740 CNV Loss 20482838
esv1109475 CNV Deletion 17803354
esv1230269 CNV Deletion 17803354
esv2719398 CNV Deletion 23290073
esv2719399 CNV Deletion 23290073
nsv828108 CNV Loss 20364138
nsv873572 CNV Gain 21882294
nsv528587 CNV Loss 19592680
nsv833237 CNV Loss 17160897
esv2663311 CNV Deletion 23128226
esv29784 CNV Loss 19812545
esv32943 CNV Gain 17666407
esv2719400 CNV Deletion 23290073
esv2661396 CNV Deletion 23128226
esv2719401 CNV Deletion 23290073
esv2669220 CNV Deletion 23128226
esv2742607 CNV Deletion 23290073
esv2719402 CNV Deletion 23290073
esv2719403 CNV Deletion 23290073
esv2719404 CNV Deletion 23290073
esv2719405 CNV Deletion 23290073
esv2604908 CNV Deletion 19546169
esv2073375 CNV Deletion 18987734
nsv213832 CNV Insertion 16902084
esv1464832 CNV Insertion 17803354
esv2719407 CNV Deletion 23290073

Variation tolerance for MYT1L Gene

Residual Variation Intolerance Score: 2.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.68; 65.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYT1L Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYT1L Gene

Disorders for MYT1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYT1L Gene - From: OMIM, ClinVar, and GeneCards

Disorder Aliases PubMed IDs
mental retardation, autosomal dominant 39
  • mrd39
- elite association - COSMIC cancer census association via MalaCards
Search MYT1L in MalaCards View complete list of genes associated with diseases


  • Mental retardation, autosomal dominant 39 (MRD39) [MIM:616521]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD39 patients show delayed psychomotor development and autistic features. {ECO:0000269 PubMed:23033978, ECO:0000269 PubMed:23160955}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MYT1L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MYT1L: view

No data available for Genatlas for MYT1L Gene

Publications for MYT1L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. (PMID: 9373037) Kim J.G. … Hudson L.D. (J. Neurosci. Res. 1997) 2 3
  3. A role for hydrogen bonding in DNA recognition by the non-classical CCHHC type zinc finger, NZF-1. (PMID: 24820620) Besold A.N. … Michel S.L. (Mol Biosyst 2014) 3
  4. Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial. (PMID: 25147783) Keene K.L. … Sale M.M. (Front Public Health 2014) 3
  5. Monozygotic twins discordant for submicroscopic chromosomal anomalies in 2p25.3 region detected by array CGH. (PMID: 23061379) Rio M. … Malan V. (Clin. Genet. 2013) 3

Products for MYT1L Gene

Sources for MYT1L Gene

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