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Aliases for MYT1L Gene

Aliases for MYT1L Gene

  • Myelin Transcription Factor 1 Like 2 3 5
  • Neural Zinc Finger Transcription Factor 1 2 3
  • MyT1-L 3 4
  • Myelin Transcription Factor 1-Like Protein 3
  • KIAA1106 4
  • ZC2H2C2 3
  • ZC2HC4B 3
  • MRD39 3
  • MyT1L 4
  • NZF1 3

External Ids for MYT1L Gene

Previous GeneCards Identifiers for MYT1L Gene

  • GC02P002305
  • GC02P002420
  • GC02P002327

Summaries for MYT1L Gene

Entrez Gene Summary for MYT1L Gene

  • This gene encodes a member of the zinc finger superfamily of transcription factors. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with autosomal mental retardation-39 and autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]

GeneCards Summary for MYT1L Gene

MYT1L (Myelin Transcription Factor 1 Like) is a Protein Coding gene. Diseases associated with MYT1L include Mental Retardation, Autosomal Dominant 39 and Autism Spectrum Disorder. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is MYT1.

UniProtKB/Swiss-Prot for MYT1L Gene

  • May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendroglia in the CNS (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYT1L Gene

Genomics for MYT1L Gene

Regulatory Elements for MYT1L Gene

Enhancers for MYT1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G002270 0.8 Ensembl ENCODE 11.7 +59.6 59620 2.3 JUND POLR2A SMARCA4 REST RAD21 NR2F2 MYT1L GC02M002304 GC02M002105
GH02G002006 0.8 ENCODE dbSUPER 5.2 +323.6 323595 2.5 CBX3 HDAC2 SMARCA4 POLR2A CTBP2 MYT1L GC02M002105 PIR43068
GH02G001835 0.5 dbSUPER 8.1 +494.7 494693 2.4 ZBTB10 CTCF ZNF341 BHLHE40 NRF1 MYT1L PXDN ENSG00000232057 GC02P001889
GH02G001829 0.5 dbSUPER 8 +500.1 500094 3.3 ZBTB10 ZEB2 ZEB1 ENSG00000228613 MYT1L PXDN ENSG00000232057 GC02P001889
GH02G001825 0.6 dbSUPER 6.2 +504.1 504141 3.2 POLR2A SMARCA4 GLIS1 ZEB2 EZH2 ZEB1 PXDN ENSG00000232057 MYT1L GC02P001889
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYT1L on UCSC Golden Path with GeneCards custom track

Genomic Location for MYT1L Gene

1,789,113 bp from pter
2,331,375 bp from pter
542,263 bases
Minus strand

Genomic View for MYT1L Gene

Genes around MYT1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYT1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYT1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYT1L Gene

Proteins for MYT1L Gene

  • Protein details for MYT1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myelin transcription factor 1-like protein
    Protein Accession:
    Secondary Accessions:
    • A7E2C7
    • B2RP54
    • Q6IQ17
    • Q9UPP6

    Protein attributes for MYT1L Gene

    1186 amino acids
    Molecular mass:
    133043 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF14051.1; Type=Frameshift; Positions=1185; Evidence={ECO:0000305}; Sequence=BAA83058.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MYT1L Gene


neXtProt entry for MYT1L Gene

Post-translational modifications for MYT1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYT1L Gene

Domains & Families for MYT1L Gene

Gene Families for MYT1L Gene

Protein Domains for MYT1L Gene

Suggested Antigen Peptide Sequences for MYT1L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYT1L: view

No data available for UniProtKB/Swiss-Prot for MYT1L Gene

Function for MYT1L Gene

Molecular function for MYT1L Gene

UniProtKB/Swiss-Prot Function:
May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendroglia in the CNS (By similarity).

Gene Ontology (GO) - Molecular Function for MYT1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ISS --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MYT1L: view
genes like me logo Genes that share phenotypes with MYT1L: view

Human Phenotype Ontology for MYT1L Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MYT1L Gene

Localization for MYT1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYT1L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYT1L gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MYT1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,ISS --
genes like me logo Genes that share ontologies with MYT1L: view

Pathways & Interactions for MYT1L Gene

SuperPathways for MYT1L Gene

No Data Available

Interacting Proteins for MYT1L Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
Selected Interacting proteins: ENSP00000396103 Q9UL68-MYT1L_HUMAN for MYT1L Gene via STRING IID

Gene Ontology (GO) - Biological Process for MYT1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter ISS --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with MYT1L: view

No data available for Pathways by source and SIGNOR curated interactions for MYT1L Gene

Drugs & Compounds for MYT1L Gene

No Compound Related Data Available

Transcripts for MYT1L Gene

Unigene Clusters for MYT1L Gene

Myelin transcription factor 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYT1L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
SP1: - - -
SP2: - -
SP4: - -

ExUns: 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b

Relevant External Links for MYT1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYT1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYT1L Gene

mRNA differential expression in normal tissues according to GTEx for MYT1L Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.8), Brain - Anterior cingulate cortex (BA24) (x5.8), Brain - Putamen (basal ganglia) (x4.7), Brain - Cerebellar Hemisphere (x4.7), Brain - Nucleus accumbens (basal ganglia) (x4.6), Brain - Cortex (x4.4), and Brain - Caudate (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for MYT1L Gene

This gene is overexpressed in Plasma (40.0), Fetal gut (18.3), and Pancreatic juice (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYT1L Gene

Protein tissue co-expression partners for MYT1L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MYT1L Gene:


SOURCE GeneReport for Unigene cluster for MYT1L Gene:


Evidence on tissue expression from TISSUES for MYT1L Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with MYT1L: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYT1L Gene

Orthologs for MYT1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYT1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MYT1L 34 35
  • 99.51 (n)
(Monodelphis domestica)
Mammalia MYT1L 35
  • 96 (a)
(Mus musculus)
Mammalia Myt1l 34 16 35
  • 89.16 (n)
(Rattus norvegicus)
Mammalia Myt1l 34
  • 87.94 (n)
(Canis familiaris)
Mammalia MYT1L 34 35
  • 87.5 (n)
(Ornithorhynchus anatinus)
Mammalia MYT1L 35
  • 86 (a)
(Bos Taurus)
Mammalia MYT1L 34 35
  • 84.14 (n)
(Gallus gallus)
Aves MYT1L 34 35
  • 84.45 (n)
(Anolis carolinensis)
Reptilia MYT1L 35
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia myt1l 34
  • 78.64 (n)
(Danio rerio)
Actinopterygii myt1la 34 35
  • 72.09 (n)
MYT1L (1 of 2) 35
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43689 35
  • 11 (a)
(Caenorhabditis elegans)
Secernentea ztf-11 35
  • 18 (a)
(Triticum aestivum)
Liliopsida Ta.6362 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 17 (a)
Species where no ortholog for MYT1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MYT1L Gene

Gene Tree for MYT1L (if available)
Gene Tree for MYT1L (if available)

Paralogs for MYT1L Gene

Paralogs for MYT1L Gene

(3) SIMAP similar genes for MYT1L Gene using alignment to 4 proteins: Pseudogenes for MYT1L Gene

genes like me logo Genes that share paralogs with MYT1L: view

Variants for MYT1L Gene

Sequence variations from dbSNP and Humsavar for MYT1L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs869320675 Pathogenic 1,887,487(-) ATAAC(A/G)TAAGC splice-donor-variant
rs869320676 Pathogenic 1,903,189(-) AAATA(G/T)TCCAA reference, stop-gained
rs886041655 Pathogenic 1,943,000(-) AGGAG(G/T)AAGAG reference, stop-gained
rs886041858 Pathogenic 1,912,024(-) CCCAC(C/T)GAAGG reference, stop-gained
rs886041944 Pathogenic 1,892,196(-) GGGGG(-/G)CAGCA reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for MYT1L Gene

Variant ID Type Subtype PubMed ID
dgv1840n106 CNV deletion 24896259
dgv673e199 CNV deletion 23128226
esv1004740 CNV loss 20482838
esv1011603 CNV deletion 17803354
esv1109475 CNV deletion 17803354
esv1230269 CNV deletion 17803354
esv1336055 CNV deletion 17803354
esv1354694 CNV insertion 17803354
esv1464832 CNV insertion 17803354
esv2045899 CNV deletion 18987734
esv2073375 CNV deletion 18987734
esv2498228 CNV deletion 19546169
esv2604908 CNV deletion 19546169
esv26151 CNV loss 19812545
esv26557 CNV gain+loss 19812545
esv2661396 CNV deletion 23128226
esv2661946 CNV deletion 23128226
esv2662310 CNV deletion 23128226
esv2663311 CNV deletion 23128226
esv2669220 CNV deletion 23128226
esv2719379 CNV deletion 23290073
esv2719380 CNV deletion 23290073
esv2719381 CNV deletion 23290073
esv2719382 CNV deletion 23290073
esv2719383 CNV deletion 23290073
esv2719385 CNV deletion 23290073
esv2719386 CNV deletion 23290073
esv2719387 CNV deletion 23290073
esv2719388 CNV deletion 23290073
esv2719389 CNV deletion 23290073
esv2719390 CNV deletion 23290073
esv2719391 CNV deletion 23290073
esv2719392 CNV deletion 23290073
esv2719393 CNV deletion 23290073
esv2719394 CNV deletion 23290073
esv2719396 CNV deletion 23290073
esv2719397 CNV deletion 23290073
esv2719398 CNV deletion 23290073
esv2719399 CNV deletion 23290073
esv2719400 CNV deletion 23290073
esv2719401 CNV deletion 23290073
esv2719402 CNV deletion 23290073
esv2719403 CNV deletion 23290073
esv2719404 CNV deletion 23290073
esv2719405 CNV deletion 23290073
esv2719407 CNV deletion 23290073
esv2742607 CNV deletion 23290073
esv2759018 CNV loss 17122850
esv29784 CNV loss 19812545
esv32943 CNV gain 17666407
esv3343222 CNV duplication 20981092
esv3408207 CNV insertion 20981092
esv3418554 CNV duplication 20981092
esv3423548 CNV insertion 20981092
esv3430396 CNV duplication 20981092
esv3551189 CNV deletion 23714750
esv3551200 CNV deletion 23714750
esv3551245 CNV deletion 23714750
esv3551300 CNV deletion 23714750
esv3583619 CNV loss 25503493
esv3583620 CNV loss 25503493
esv3589635 CNV loss 21293372
esv3589636 CNV loss 21293372
esv3589639 CNV loss 21293372
esv3891470 CNV gain 25118596
esv999007 CNV deletion 20482838
nsv1001231 CNV gain 25217958
nsv1004175 CNV loss 25217958
nsv1007958 CNV gain 25217958
nsv1071562 CNV deletion 25765185
nsv1071961 CNV deletion 25765185
nsv1077346 CNV duplication 25765185
nsv1117157 CNV deletion 24896259
nsv1117225 CNV tandem duplication 24896259
nsv1118624 CNV duplication 24896259
nsv1119474 CNV insertion 24896259
nsv1127703 CNV deletion 24896259
nsv1130744 CNV deletion 24896259
nsv1140150 CNV insertion 24896259
nsv1150400 CNV deletion 26484159
nsv1152681 CNV duplication 26484159
nsv1153258 CNV duplication 26484159
nsv213819 CNV deletion 16902084
nsv213832 CNV insertion 16902084
nsv215466 CNV deletion 16902084
nsv2571 CNV insertion 18451855
nsv433166 CNV loss 18776910
nsv470440 CNV gain 18288195
nsv475462 CNV novel sequence insertion 20440878
nsv478496 CNV novel sequence insertion 20440878
nsv508801 CNV insertion 20534489
nsv528587 CNV loss 19592680
nsv580767 CNV gain 21841781
nsv580768 CNV loss 21841781
nsv820484 CNV deletion 20802225
nsv828108 CNV loss 20364138
nsv833215 CNV loss 17160897
nsv833226 CNV loss 17160897
nsv833237 CNV loss 17160897
nsv9280 CNV gain 18304495
nsv953376 CNV deletion 24416366
nsv998477 CNV gain 25217958
nsv999928 CNV gain 25217958

Variation tolerance for MYT1L Gene

Residual Variation Intolerance Score: 2.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.68; 65.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYT1L Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYT1L Gene

Disorders for MYT1L Gene

MalaCards: The human disease database

(2) MalaCards diseases for MYT1L Gene - From: OMIM, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
mental retardation, autosomal dominant 39
  • mrd39
autism spectrum disorder
  • pervasive development disorder
- elite association - COSMIC cancer census association via MalaCards
Search MYT1L in MalaCards View complete list of genes associated with diseases


  • Mental retardation, autosomal dominant 39 (MRD39) [MIM:616521]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD39 patients show delayed psychomotor development and autistic features. {ECO:0000269 PubMed:23033978, ECO:0000269 PubMed:23160955}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MYT1L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MYT1L: view

No data available for Genatlas for MYT1L Gene

Publications for MYT1L Gene

  1. Diagnostic exome sequencing in persons with severe intellectual disability. (PMID: 23033978) de Ligt J. … Vissers L.E. (N. Engl. J. Med. 2012) 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population. (PMID: 21048971) Wang T. … Shi Y. (PLoS ONE 2010) 3 46 64
  4. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PMID: 18839057) Lesch K.P. … Jacob C. (J Neural Transm 2008) 3 46 64
  5. Recurrent CNVs disrupt three candidate genes in schizophrenia patients. (PMID: 18940311) Vrijenhoek T. … Veltman J.A. (Am. J. Hum. Genet. 2008) 3 46 64

Products for MYT1L Gene

  • Addgene plasmids for MYT1L

Sources for MYT1L Gene

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