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Aliases for MYT1L Gene

Aliases for MYT1L Gene

  • Myelin Transcription Factor 1-Like 2 3
  • Neural Zinc Finger Transcription Factor 1 2 3
  • KIAA1106 4 6
  • MyT1-L 3 4
  • Myelin Transcription Factor 1-Like Protein 3
  • ZC2HC4B 3
  • MyT1L 4
  • NZF1 3

External Ids for MYT1L Gene

Summaries for MYT1L Gene

GeneCards Summary for MYT1L Gene

MYT1L (Myelin Transcription Factor 1-Like) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ST18.

UniProtKB/Swiss-Prot for MYT1L Gene

  • May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendrogalia in the CNS (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYT1L Gene

Genomics for MYT1L Gene

Genomic Location for MYT1L Gene

Start:
1,789,113 bp from pter
End:
2,331,273 bp from pter
Size:
542,161 bases
Orientation:
Minus strand

Genomic View for MYT1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYT1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYT1L Gene

Regulatory Elements for MYT1L Gene

Proteins for MYT1L Gene

  • Protein details for MYT1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL68-MYT1L_HUMAN
    Recommended name:
    Myelin transcription factor 1-like protein
    Protein Accession:
    Q9UL68
    Secondary Accessions:
    • A7E2C7
    • B2RP54
    • Q6IQ17
    • Q9UPP6

    Protein attributes for MYT1L Gene

    Size:
    1186 amino acids
    Molecular mass:
    133043 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF14051.1; Type=Frameshift; Positions=1185; Evidence={ECO:0000305}; Sequence=BAA83058.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MYT1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYT1L Gene

Proteomics data for MYT1L Gene at MOPED

Post-translational modifications for MYT1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYT1L Gene

No data available for DME Specific Peptides for MYT1L Gene

Domains for MYT1L Gene

Gene Families for MYT1L Gene

HGNC:
  • ZC2HC :Zinc fingers, C2HC-type containing

Protein Domains for MYT1L Gene

UniProtKB/Swiss-Prot:

MYT1L_HUMAN
Similarity:
  • Contains 6 C2HC-type zinc fingers.:
    • Q9UL68
genes like me logo Genes that share domains with MYT1L: view

Function for MYT1L Gene

Molecular function for MYT1L Gene

UniProtKB/Swiss-Prot Function: May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendrogalia in the CNS (By similarity).

Gene Ontology (GO) - Molecular Function for MYT1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MYT1L: view

Phenotypes for MYT1L Gene

GenomeRNAi human phenotypes for MYT1L:
genes like me logo Genes that share phenotypes with MYT1L: view

miRNA for MYT1L Gene

miRTarBase miRNAs that target MYT1L

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MYT1L Gene

Localization for MYT1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYT1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYT1L Gene COMPARTMENTS Subcellular localization image for MYT1L gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for MYT1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with MYT1L: view

Pathways for MYT1L Gene

SuperPathways for MYT1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYT1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with MYT1L: view

No data available for Pathways by source for MYT1L Gene

Transcripts for MYT1L Gene

Unigene Clusters for MYT1L Gene

Myelin transcription factor 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYT1L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
SP1: - - -
SP2: - -
SP3:
SP4: - -
SP5:
SP6:
SP7:

ExUns: 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for MYT1L Gene

GeneLoc Exon Structure for
MYT1L
ECgene alternative splicing isoforms for
MYT1L

Expression for MYT1L Gene

mRNA expression in normal human tissues for MYT1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYT1L Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (6.8), Brain - Anterior cingulate cortex (BA24) (5.8), Brain - Putamen (basal ganglia) (4.7), Brain - Cerebellar Hemisphere (4.7), Brain - Nucleus accumbens (basal ganglia) (4.6), Brain - Cortex (4.4), and Brain - Caudate (basal ganglia) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYT1L Gene

SOURCE GeneReport for Unigene cluster for MYT1L Gene Hs.434418

genes like me logo Genes that share expressions with MYT1L: view

Orthologs for MYT1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYT1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYT1L 36
  • 99.51 (n)
  • 100 (a)
MYT1L 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYT1L 36
  • 84.14 (n)
  • 90.8 (a)
MYT1L 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYT1L 36
  • 87.5 (n)
  • 94.18 (a)
MYT1L 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myt1l 36
  • 89.16 (n)
  • 96.15 (a)
Myt1l 16
Myt1l 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYT1L 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYT1L 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myt1l 36
  • 87.94 (n)
  • 93.77 (a)
chicken
(Gallus gallus)
Aves MYT1L 36
  • 84.45 (n)
  • 95.26 (a)
MYT1L 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYT1L 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myt1l 36
  • 78.64 (n)
  • 88.33 (a)
zebrafish
(Danio rerio)
Actinopterygii MYT1L (1 of 2) 37
  • 62 (a)
OneToMany
myt1la 36
  • 72.09 (n)
  • 76.05 (a)
myt1la 37
  • 65 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43689 37
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ztf-11 37
  • 18 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.6362 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 17 (a)
OneToMany
Species with no ortholog for MYT1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MYT1L Gene

ENSEMBL:
Gene Tree for MYT1L (if available)
TreeFam:
Gene Tree for MYT1L (if available)

Paralogs for MYT1L Gene

Paralogs for MYT1L Gene

Selected SIMAP similar genes for MYT1L Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for MYT1L Gene

genes like me logo Genes that share paralogs with MYT1L: view

Variants for MYT1L Gene

Sequence variations from dbSNP and Humsavar for MYT1L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs725311 -- 2,047,858(-) GTTTC(A/G)TATTT intron-variant
rs747470 -- 1,893,201(+) CTTTA(A/G)TACAT intron-variant
rs748622 -- 1,948,682(-) TTCAC(G/T)GGTGT intron-variant
rs748623 -- 1,948,465(-) AGCCA(C/T)GTGGA intron-variant
rs752491 -- 2,266,521(+) ATTTC(A/G)CAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYT1L Gene

Variant ID Type Subtype PubMed ID
nsv873564 CNV Gain 21882294
nsv873570 CNV Loss 21882294
nsv470440 CNV Gain 18288195
nsv873571 CNV Loss 21882294
esv2719379 CNV Deletion 23290073
esv2719380 CNV Deletion 23290073
esv1354694 CNV Insertion 17803354
esv2719381 CNV Deletion 23290073
esv2719382 CNV Deletion 23290073
esv2719383 CNV Deletion 23290073
nsv215466 CNV Loss 16902084
nsv213819 CNV Loss 16902084
nsv508801 CNV Insertion 20534489
esv2719385 CNV Deletion 23290073
esv2719386 CNV Deletion 23290073
esv2719387 CNV Deletion 23290073
esv2719388 CNV Deletion 23290073
nsv433166 CNV Loss 18776910
dgv1139e1 CNV Complex 17122850
nsv833215 CNV Loss 17160897
esv2719389 CNV Deletion 23290073
esv2719390 CNV Deletion 23290073
esv1011603 CNV Deletion 17803354
esv2719391 CNV Deletion 23290073
esv2719392 CNV Deletion 23290073
nsv9280 CNV Gain 18304495
esv2719393 CNV Deletion 23290073
esv2661946 CNV Deletion 23128226
esv999007 CNV Deletion 20482838
esv1336055 CNV Deletion 17803354
nsv833226 CNV Loss 17160897
esv2719394 CNV Deletion 23290073
dgv673e199 CNV Deletion 23128226
esv26151 CNV Loss 19812545
esv2662310 CNV Deletion 23128226
esv2045899 CNV Deletion 18987734
nsv2571 CNV Insertion 18451855
esv26557 CNV Gain+Loss 19812545
esv2719396 CNV Deletion 23290073
esv2498228 CNV Deletion 19546169
nsv820484 CNV Deletion 20802225
esv2719397 CNV Deletion 23290073
esv1004740 CNV Loss 20482838
esv1109475 CNV Deletion 17803354
esv1230269 CNV Deletion 17803354
esv2719398 CNV Deletion 23290073
esv2719399 CNV Deletion 23290073
nsv828108 CNV Loss 20364138
nsv873572 CNV Gain 21882294
nsv528587 CNV Loss 19592680
nsv833237 CNV Loss 17160897
esv2663311 CNV Deletion 23128226
esv29784 CNV Loss 19812545
esv32943 CNV Gain 17666407
esv2719400 CNV Deletion 23290073
esv2661396 CNV Deletion 23128226
esv2719401 CNV Deletion 23290073
esv2669220 CNV Deletion 23128226
esv2742607 CNV Deletion 23290073
esv2719402 CNV Deletion 23290073
esv2719403 CNV Deletion 23290073
esv2719404 CNV Deletion 23290073
esv2719405 CNV Deletion 23290073
esv2604908 CNV Deletion 19546169
esv2073375 CNV Deletion 18987734
nsv213832 CNV Insertion 16902084
esv1464832 CNV Insertion 17803354
esv2719407 CNV Deletion 23290073

Relevant External Links for MYT1L Gene

HapMap Linkage Disequilibrium report
MYT1L
Human Gene Mutation Database (HGMD)
MYT1L

Disorders for MYT1L Gene

(1) University of Copenhagen DISEASES for MYT1L Gene

Relevant External Links for MYT1L

Genetic Association Database (GAD)
MYT1L
Human Genome Epidemiology (HuGE) Navigator
MYT1L
genes like me logo Genes that share disorders with MYT1L: view

No data available for UniProtKB/Swiss-Prot for MYT1L Gene

Publications for MYT1L Gene

  1. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PMID: 18839057) Lesch K.P. … Jacob C. (J Neural Transm 2008) 3 49
  2. Recurrent CNVs disrupt three candidate genes in schizophrenia patients. (PMID: 18940311) Vrijenhoek T. … Veltman J.A. (Am. J. Hum. Genet. 2008) 3 49
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population. (PMID: 21048971) Wang T. … Shi Y. (PLoS ONE 2010) 3 49
  5. Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. (PMID: 9373037) Kim J.G. … Hudson L.D. (J. Neurosci. Res. 1997) 2 3

Products for MYT1L Gene

  • Addgene plasmids for MYT1L

Sources for MYT1L Gene

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