Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MYT1L Gene

protein-coding   GIFtS: 56
GCID: GC02M001763

Myelin Transcription Factor 1-Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Myelin Transcription Factor 1-Like1 2     myT1-L2
Neural Zinc Finger Transcription Factor 11 2     Myelin Transcription Factor 1-Like Protein2
KIAA11063 5     MyT1-L3
NZF12     MyT1L3
ZC2HC4B2     

External Ids:    HGNC: 76231   Entrez Gene: 230402   Ensembl: ENSG000001864877   OMIM: 6130845   UniProtKB: Q9UL683   

Export aliases for MYT1L gene to outside databases

Previous GC identifers: GC02P002305 GC02P002420 GC02P002327


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for MYT1L Gene:
MYT1L (myelin transcription factor 1-like) is a protein-coding gene. Diseases associated with MYT1L include diffuse astrocytoma, and major depressive disorder. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ST18.

UniProtKB/Swiss-Prot: MYT1L_HUMAN, Q9UL68
Function: May function as a panneural transcription factor associated with neuronal differentiation. May play a
role in the development of neurons and oligodendrogalia in the CNS (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NT_005334.17  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYT1L gene promoter:
         Pax-6   Tal-1beta   E4BP4   E47   GATA-1   MEF-2A   POU2F1   POU2F1a   TFIID   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYT1L promoter sequence
   Search Chromatin IP Primers for MYT1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYT1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.3   Ensembl cytogenetic band:  2p25.3   HGNC cytogenetic band: 2p25.3

MYT1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYT1L gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M001763:  view genomic region     (about GC identifiers)

Start:
1,792,885 bp from pter      End:
2,335,045 bp from pter
Size:
542,161 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MYT1L_HUMAN, Q9UL68 (See protein sequence)
Recommended Name: Myelin transcription factor 1-like protein  
Size: 1186 amino acids; 133043 Da
Sequence caution: Sequence=AAF14051.1; Type=Frameshift; Positions=1185; Sequence=BAA83058.2; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7E2C7 B2RP54 Q6IQ17 Q9UPP6
Alternative splicing: 4 isoforms:  Q9UL68-1   Q9UL68-2   Q9UL68-3   Q9UL68-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYT1L: NX_Q9UL68

Explore proteomics data for MYT1L at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYT1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055840.2  
    ENSEMBL proteins: 
     ENSP00000382114   ENSP00000384219   ENSP00000382111   ENSP00000396103   ENSP00000473409  

    MYT1L Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MYT1L
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MYT1L
    GenScript Custom Purified and Recombinant Proteins Services for MYT1L
    Novus Biologicals MYT1L Protein
    Novus Biologicals MYT1L Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYT1L

    MYT1L Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MYT1L
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MYT1L
    OriGene Custom Antibody Services for MYT1L
    Novus Biologicals MYT1L Antibody
    Abcam antibodies for MYT1L
    Cloud-Clone Corp. Antibodies for MYT1L
    ThermoFisher Antibodies for MYT1L
    LSBio Antibodies in human, mouse, rat for MYT1L

    MYT1L Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MYT1L
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYT1L
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYT1L
    Cloud-Clone Corp. CLIAs for MYT1L


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZC2HC: Zinc fingers, C2HC-type containing

    2 InterPro protein domains:
     IPR002515 Znf_C2HC
     IPR013681 Myelin_TF

    Graphical View of Domain Structure for InterPro Entry Q9UL68

    ProtoNet protein and cluster: Q9UL68

    1 Blocks protein domain: IPB013681 Myelin transcription factor 1

    UniProtKB/Swiss-Prot: MYT1L_HUMAN, Q9UL68
    Similarity: Contains 6 C2HC-type zinc fingers


    MYT1L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYT1L_HUMAN, Q9UL68
    Function: May function as a panneural transcription factor associated with neuronal differentiation. May play a
    role in the development of neurons and oligodendrogalia in the CNS (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    MYT1L for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MYT1L:
     Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYT1L
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYT1L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYT1L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYT1L

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYT1L:
    hsa-mir-335-5p (MIRT017380), hsa-mir-26b-5p (MIRT029154)

    Block miRNA regulation of human, mouse, rat MYT1L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYT1L (see all 188):
    hsa-miR-576-3p hsa-miR-100* hsa-miR-361-5p hsa-miR-106a hsa-miR-605 hsa-miR-519a hsa-miR-877* hsa-miR-1273d
    SwitchGear 3'UTR luciferase reporter plasmidMYT1L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MYT1L
    Predesigned siRNA for gene silencing in human, mouse, rat MYT1L

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYT1L

    Clone
    Products:
         
    OriGene clones in human, mouse for MYT1L (see all 9)
    OriGene ORF clones in mouse, rat for MYT1L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYT1L (NM_015025)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYT1L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYT1L

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MYT1L
    Browse ESI BIO Cell Lines and PureStem Progenitors for MYT1L 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYT1L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MYT1L_HUMAN, Q9UL68: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--

    MYT1L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYT1L
    Interactions:

        Search GeneGlobe Interaction Network for MYT1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for MYT1L (Q9UL683 ENSP000003961034) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DISC1Q9NRI53, ENSP000003555964I2D: score=2 STRING: ENSP00000355596
    CDC5LQ994593, ENSP000003605324I2D: score=2 STRING: ENSP00000360532
    TNIKQ9UKE53, ENSP000003995114I2D: score=1 STRING: ENSP00000399511
    NR4A1P227363I2D: score=1 
    PCBD1P614573I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--

    MYT1L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYT1L



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MYT1L gene: 
    NM_015025.2  

    Unigene Cluster for MYT1L:

    Myelin transcription factor 1-like
    Hs.434418  [show with all ESTs]
    Unigene Representative Sequence: NM_015025
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399161(uc010ewl.2 uc002qxd.3 uc002qxe.3) ENST00000407844(uc010ewk.3)
    ENST00000399157 ENST00000428368(uc002qxf.1) ENST00000471668 ENST00000602387
    ENST00000470954 ENST00000490585 ENST00000485547 ENST00000485348 ENST00000479156
    ENST00000476547 ENST00000460585
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MYT1L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYT1L (see all 188):
    hsa-miR-576-3p hsa-miR-100* hsa-miR-361-5p hsa-miR-106a hsa-miR-605 hsa-miR-519a hsa-miR-877* hsa-miR-1273d
    SwitchGear 3'UTR luciferase reporter plasmidMYT1L 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MYT1L
    Predesigned siRNA for gene silencing in human, mouse, rat MYT1L
    Clone
    Products:
         
    OriGene clones in human, mouse for MYT1L (see all 9)
    OriGene ORF clones in mouse, rat for MYT1L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYT1L (NM_015025)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYT1L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYT1L
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MYT1L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYT1L
      QuantiTect SYBR Green Assays in human, mouse, rat MYT1L
      QuantiFast Probe-based Assays in human, mouse, rat MYT1L

    Additional mRNA sequence: 

    AB029029.2 AB073885.1 AF036943.1 AK299571.1 AK307797.1 AL133024.1 BC042833.1 BC071612.1 
    BC109113.1 BC137272.1 BC137273.1 BC150281.1 

    9 DOTS entries:

    DT.95263373  DT.100669960  DT.113247  DT.75140045  DT.120938384  DT.120938427  DT.423323  DT.97814501 
    DT.409114 

    Selected AceView cDNA sequences (see all 88):

    BX645114 BM662061 AA935924 AI696518 AW207596 BC031690 F04633 AI280086 
    Z45757 AW952686 AW510843 BE218864 Z41381 CK825025 BM678566 BM701291 
    AW419345 BF223003 F08380 BM312185 BE217813 BF110887 AB029029 AW450432 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYT1L (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
    SP1:                                                                                                  -                             -           -               
    SP2:                                                                                            -     -                                                         
    SP3:                                                                                                                                                            
    SP4:              -     -                                                                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for MYT1L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MYT1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGATGTTA
    MYT1L Expression
    About this image


    MYT1L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)
             Amygdala
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
    MYT1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYT1L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434418
        Custom PCR Arrays for MYT1L
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MYT1L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYT1L
    QuantiTect SYBR Green Assays in human, mouse, rat MYT1L
    QuantiFast Probe-based Assays in human, mouse, rat MYT1L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYT1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MYT1L gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myt1l1 , 5 myelin transcription factor 1-like1, 5 89.16(n)1
    96.15(a)1
      12 (11.86 cM)5
    179331  NM_001093778.11  NP_001087247.11 
     295283845 
    chicken
    (Gallus gallus)
    Aves MYT1L1 myelin transcription factor 1-like 84.45(n)
    95.26(a)
      421915  XM_004940507.1  XP_004940564.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYT1L6
    myelin transcription factor 1-like
    90(a)
    1 ↔ 1
    1(161467386-161679079)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia myt1l1 myelin transcription factor 1-like 78.64(n)
    88.33(a)
      100494385  XM_002936297.2  XP_002936343.2 
    zebrafish
    (Danio rerio)
    Actinopterygii myt1la1 myelin transcription factor 1-like, a 72.09(n)
    76.05(a)
      559505  NM_001044899.2  NP_001038364.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG436896
    --
    11(a)
    1 → many
    X(3970107-3986186)
    worm
    (Caenorhabditis elegans)
    Secernentea ztf-116
    Protein ZTF-11, isoform b (ztf-11) mRNA, complete ...
    18(a)
    1 → many
    I(9902943-9910545) WBGene00009939
    wheat
    (Triticum aestivum)
    Liliopsida Ta.63622 Triticum aestivum transcribed sequence with weak similarity more 72.07(n)    CD903123.1 


    ENSEMBL Gene Tree for MYT1L (if available)
    TreeFam Gene Tree for MYT1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MYT1L gene
    ST182  MYT12  
    3 SIMAP similar genes for MYT1L using alignment to 4 protein entries:     MYT1L_HUMAN (see all proteins):
    MYT1    L3MBTL1    ST18

    MYT1L for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MYT1L
    PGOHUM00000237356


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MYT1L (see all 11646)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899050961,2
    Cuntested12304433(+) CCATGC/G/TGCATT 1 -- int10--------
    rs1417045071,2
    --1792390(+) GTCTGC/TTCAGT 1 -- int10--------
    rs101754671,2
    C,A--1792451(-) GGCGCG/ACTGCT 1 -- int14Minor allele frequency- A:0.07NA CSA 125
    rs1118580861,2
    F--1792492(+) ACAAAG/AGACGT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs102093491,2
    C,F,A--1792612(-) CTCCCG/AGCACA 1 -- int13Minor allele frequency- A:0.20NA CSA 5
    rs752407151,2
    F--1792631(+) TCCTCC/TGTCCA 1 -- int11Minor allele frequency- T:0.01WA 118
    rs755663991,2
    C,F--1792632(+) CCTCCG/ATCCAG 1 -- int11Minor allele frequency- A:0.04WA 118
    rs1496339971,2
    --1792755(+) TTCTAC/TATGCC 1 -- int10--------
    rs21619701,2
    H--1792950(-) TGCTGG/CATGTT 1 -- ut314Minor allele frequency- C:0.00NS EA 420
    rs790540231,2
    --1793211(+) ATCCAC/TATGAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MYT1L (1792885 - 2042885 bp, first 250kb of MYT1L)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MYT1L (see all 68):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2604908CNV Deletion19546169
    esv2719380CNV Deletion23290073
    esv2719385CNV Deletion23290073
    esv2719387CNV Deletion23290073
    esv2719405CNV Deletion23290073
    esv2719404CNV Deletion23290073
    esv2719398CNV Deletion23290073
    esv2045899CNV Deletion18987734
    esv2719399CNV Deletion23290073
    esv2663311CNV Deletion23128226

    Human Gene Mutation Database (HGMD): MYT1L
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYT1L
    DNA2.0 Custom Variant and Variant Library Synthesis for MYT1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 613084    OMIM disorders: --

    9 diseases for MYT1L:    
    About MalaCards
    diffuse astrocytoma    major depressive disorder    intellectual disability    diabetic retinopathy
    astrocytoma    sinusitis    schizophrenia    neuronitis
    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for MYT1L:
    Schizophrenia

    MYT1L for disorders           About GeneDecksing

    Genetic Association Database (GAD): MYT1L
    Human Genome Epidemiology (HuGE) Navigator: MYT1L (4 documents)

    Export disorders for MYT1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MYT1L gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with MYT1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population. (PubMed id 21048971)1, 4 Wang T....Shi Y. (PLoS ONE 2010)
    3. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1, 4 Lesch K.P....Jacob C. (J Neural Transm 2008)
    4. Recurrent CNVs disrupt three candidate genes in schizophrenia patients. (PubMed id 18940311)1, 4 Vrijenhoek T....Veltman J.A. (Am. J. Hum. Genet. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    7. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    8. Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. (PubMed id 9373037)1, 3 Kim J.G....Hudson L.D. (J. Neurosci. Res. 1997)
    9. From the Cover: Neutralization of terminal differentiation in gliomagenesis. (PubMed id 23918370)1 Hu J....DePinho R.A. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    10. Monozygotic twins discordant for submicroscopic chromosomal anomalies in 2p25.3 region detected by array CGH. (PubMed id 23061379)1 Rio M....Malan V. (Clin. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23040 HGNC: 7623 AceView: MYT1L Ensembl:ENSG00000186487 euGenes: HUgn23040
    ECgene: MYT1L H-InvDB: MYT1L

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1106

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MYT1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MYT1L gene:
    Search GeneIP for patents involving MYT1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of MYT1L
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MYT1L   OriGene RNAi products in human, mouse, rat for MYT1L  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MYT1L  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MYT1L  
     OriGene qSTAR qPCR primer pairs in human, mouse for MYT1L   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MYT1L   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MYT1L   OriGene Custom Protein Services for MYT1L  

     
     
     Block miRNA regulation of human, mouse, rat MYT1L using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MYT1L
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYT1L Predesigned siRNA for gene silencing in human, mouse, rat MYT1L
     QuantiFast Probe-based Assays in human, mouse, rat MYT1L QuantiTect SYBR Green Assays in human, mouse, rat MYT1L
     Custom PCR Arrays for MYT1L Search Chromatin IP Primers for MYT1L
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYT1L  Search GeneGlobe Interaction Network for MYT1L
     Regulatory tfbs in MYT1L promoter
     GenScript Custom Purified and Recombinant Proteins Services for MYT1L GenScript cDNA clones with any tag delivered in your preferred vector for MYT1L
     GenScript Custom Assay Services for MYT1L GenScript Custom overexpressing Cell Line Services for MYT1L
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MYT1L
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MYT1L antibodies
     MYT1L proteins
     MYT1L lysates
     Antibodies for MYT1L
     See all of Abcam's Antibodies, Kits and Proteins for MYT1L
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MYT1L
     Antibodies for MYT1L
     ELISAs for MYT1L
     CLIAs for MYT1L



     Browse ESI BIO Cell Lines and PureStem Progenitors for MYT1L
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYT1L
     SwitchGear 3'UTR luciferase reporter plasmids for MYT1L
     SwitchGear Promoter luciferase reporter plasmids for MYT1L
     ThermoFisher Antibodies for MYT1L
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYT1L
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYT1L
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYT1L
     LSBio Antibodies in human, mouse, rat for MYT1L
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MYT1L gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4