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MYT1 Gene

protein-coding   GIFtS: 60
GCID: GC20P062796

Myelin Transcription Factor 1


(Previous symbol: PLPB1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myelin Transcription Factor 11 2     NZF22
PLPB11 2 3 5     ZC2HC4A2
Neural Zinc Finger Transcription Factor 21 2     Proteolipid Protein Binding Protein2
Myelin Transcription Factor I2 3     KIAA08353
Proteolipid Protein-Binding Protein2 3     KIAA10503
MTF12 3     MyT13
MYTI2 3     MyTI3
C20orf362     

External Ids:    HGNC: 76221   Entrez Gene: 46612   Ensembl: ENSG000001961327   OMIM: 6003795   UniProtKB: Q015383   

Export aliases for MYT1 gene to outside databases

Previous GC identifers: GC20P062673 GC20P063475 GC20P063522 GC20P062253 GC20P062266 GC20P062795 GC20P059521


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYT1 Gene:
The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding
proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and
plays a role in the developing nervous system. (provided by RefSeq, Jul 2008)

GeneCards Summary for MYT1 Gene:
MYT1 (myelin transcription factor 1) is a protein-coding gene. Diseases associated with MYT1 include leukomalacia, and periventricular leukomalacia. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MYT1L.

UniProtKB/Swiss-Prot: MYT1_HUMAN, Q01538
Function: Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in
the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in
oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal
differentiation and up-regulation of myelin gene transcription

Gene Wiki entry for MYT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  NT_187624.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYT1 gene promoter:
         HFH-3   MyoD   HNF-3beta   C/EBPalpha   CREB   FOXI1   POU2F1   POU2F1a   deltaCREB   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYT1 promoter sequence
   Search Chromatin IP Primers for MYT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

MYT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYT1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P062796:  view genomic region     (about GC identifiers)

Start:
62,783,144 bp from pter      End:
62,873,606 bp from pter
Size:
90,463 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MYT1_HUMAN, Q01538 (See protein sequence)
Recommended Name: Myelin transcription factor 1  
Size: 1121 amino acids; 122329 Da
Subunit: Interacts with STEAP3
Sequence caution: Sequence=BAA74858.2; Type=Erroneous initiation;
Secondary accessions: E1P5H0 O94922 Q9UPV2

Explore the universe of human proteins at neXtProt for MYT1: NX_Q01538

Explore proteomics data for MYT1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004526.1  
    ENSEMBL proteins: 
     ENSP00000327465   ENSP00000442412   ENSP00000353269  

    MYT1 Human Recombinant Protein Products:

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    Novus Biologicals MYT1 Protein
    Novus Biologicals MYT1 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYT1

    MYT1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MYT1
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    Abcam antibodies for MYT1
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    ThermoFisher Antibodies for MYT1
    LSBio Antibodies in human, mouse, rat for MYT1

    MYT1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MYT1
    Cloud-Clone Corp. CLIAs for MYT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZC2HC: Zinc fingers, C2HC-type containing

    2 InterPro protein domains:
     IPR002515 Znf_C2HC
     IPR013681 Myelin_TF

    Graphical View of Domain Structure for InterPro Entry Q01538

    ProtoNet protein and cluster: Q01538

    1 Blocks protein domain: IPB013681 Myelin transcription factor 1

    UniProtKB/Swiss-Prot: MYT1_HUMAN, Q01538
    Domain: Contains 7 zinc fingers of the C2HC class arranged in two widely separated clusters. These two domains of
    DNA binding can function independently and recognize the same DNA sequence
    Similarity: Contains 7 C2HC-type zinc fingers


    MYT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYT1_HUMAN, Q01538
    Function: Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in
    the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in
    oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal
    differentiation and up-regulation of myelin gene transcription

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001158enhancer sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS1280325
    GO:0005515protein binding ----
    GO:0008270zinc ion binding NAS1280325
         
    MYT1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MYT1:
     Upregulation of Wnt/beta-caten 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Myt1):
     endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  muscle 

    MYT1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Myt1tm1.1Ggu for MYT1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYT1

    miRNA
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    miRTarBase miRNAs that target MYT1:
    hsa-mir-27a-3p (MIRT001770)

    Block miRNA regulation of human, mouse, rat MYT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYT1 (see all 53):
    hsa-miR-429 hsa-miR-146a hsa-miR-128 hsa-miR-16-1* hsa-miR-301a hsa-miR-138-2* hsa-miR-519a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidMYT1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MYT1
    Predesigned siRNA for gene silencing in human, mouse, rat MYT1

    Gene Editing
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    OriGene ORF clones in mouse, rat for MYT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYT1 (NM_004535)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYT1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MYT1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYT1_HUMAN, Q01538: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS1280325

    MYT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYT1 About    
    See pathways by source

    SuperPathContained pathways About
    1Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    2E2F mediated regulation of DNA replication
    G1 to S cell cycle control0.35
    3Mitotic Roles of Polo Like Kinases
    Mitotic Roles of Polo Like Kinases
    4Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    5Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYT1
        Cyclins and Cell Cycle Regulation
    Mitotic Roles of Polo Like Kinases

    3 BioSystems Pathways for MYT1
        G1 to S cell cycle control
    Integrated Breast Cancer Pathway
    Integrated Pancreatic Cancer Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYT1
    Interactions:

        GeneGlobe Interaction Network for MYT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for MYT1 (Q015383 ENSP000003274654) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIN3BO751823, ENSP000003691314I2D: score=2 STRING: ENSP00000369131
    PIN1Q135263, ENSP000002479704I2D: score=3 STRING: ENSP00000247970
    PLK1P533503, ENSP000003000934I2D: score=2 STRING: ENSP00000300093
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    CDK1P064933I2D: score=3 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated NAS1280325
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--

    MYT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYT1

    3 Novoseek inferred chemical compound relationships for MYT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepa 73.5 2 9111349 (1), 9507026 (1)
    zinc 52.1 28 9507026 (10), 9111349 (3), 9478997 (2), 14962745 (1) (see all 6)
    cadmium 27 11 9507026 (8)



    MYT1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MYT1 gene: 
    NM_004535.2  

    Unigene Cluster for MYT1:

    Myelin transcription factor 1
    Hs.279562  [show with all ESTs]
    Unigene Representative Sequence: NM_004535
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328439(uc002yii.3) ENST00000536311(uc002yij.3) ENST00000360149(uc002yih.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat MYT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYT1 (see all 53):
    hsa-miR-429 hsa-miR-146a hsa-miR-128 hsa-miR-16-1* hsa-miR-301a hsa-miR-138-2* hsa-miR-519a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidMYT1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MYT1
    Predesigned siRNA for gene silencing in human, mouse, rat MYT1
    Clone
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    OriGene clones in human, mouse for MYT1 (see all 5)
    OriGene ORF clones in mouse, rat for MYT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYT1 (NM_004535)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYT1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MYT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYT1
      QuantiTect SYBR Green Assays in human, mouse, rat MYT1
      QuantiFast Probe-based Assays in human, mouse, rat MYT1

    Additional mRNA sequence: 

    AB020642.1 BC018917.2 BC053638.1 BC062313.1 M96980.1 

    7 DOTS entries:

    DT.310985  DT.100811158  DT.75129887  DT.97823245  DT.120823546  DT.100020123  DT.92419813 

    Selected AceView cDNA sequences (see all 296):

    N48465 R98114 NM_004535 BE327085 CR624439 BC040945 AA430752 BM822794 
    AA421161 BM563327 AI469021 BC053638 T06192 BU581182 AL039567 BG675029 
    BM996236 BM668232 CA776650 BC032332 BX093993 AK001745 AI681678 BQ640685 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYT1 (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c · 22d ·
    SP1:        -     -     -     -     -           -                                                                                                               
    SP2:        -     -     -     -     -           -                             -                                                                                 
    SP3:                                                                                                                    -     -     -     -                     
    SP4:                                                                                                                    -     -     -     -                     
    SP5:                                                                                                                    -     -     -     -                 -   

    ExUns: 22e ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b · 30c · 30d
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:        -     -                                   -     -           -                           
    SP4:        -     -                                   -                 -                           
    SP5:  -     -     -     -                             -                 -                           


    ECgene alternative splicing isoforms for MYT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MYT1 Expression
    About this image


    MYT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Blood (Hematopoietic System)
             Erythroblasts Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             Retina
     
     Neural Tube (Nervous System)
             Oligodendrocyte Precursor Cells Motor Neural Progenitor Domain
     
     Brain (Nervous System)
             Oligodendrocyte Precursor Cells Motor Neural Progenitor Domain
    MYT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.279562

    UniProtKB/Swiss-Prot: MYT1_HUMAN, Q01538
    Tissue specificity: Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte
    lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes

        Custom PCR Arrays for MYT1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MYT1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myt11 , 5 myelin transcription factor 11, 5 86.14(n)1
    90.72(a)1
      2 (103.77 cM)5
    179321  NM_001171615.11  NP_001165086.11 
     1817633325 
    chicken
    (Gallus gallus)
    Aves MYT11 myelin transcription factor 1 79.14(n)
    83.15(a)
      419249  XM_417423.4  XP_417423.4 
    lizard
    (Anolis carolinensis)
    Reptilia MYT16
    myelin transcription factor 1
    84(a)
    1 ↔ 1
    4(154535296-154594614)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979822 C2-HC type zinc finger protein X-MyT1 76.92(n)    U67078.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myt1a1 myelin transcription factor 1a 71.52(n)
    74.47(a)
      557002  XM_679958.6  XP_685050.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG436896
    --
    10(a)
    1 → many
    X(3970107-3986186)
    worm
    (Caenorhabditis elegans)
    Secernentea ztf-116
    Protein ZTF-11, isoform b (ztf-11) mRNA, complete ...
    18(a)
    1 → many
    I(9902943-9910545) WBGene00009939
    soybean
    (Glycine max)
    eudicotyledons Gma.177222 Transcribed sequence with weak similarity to protein more 74.38(n)  


    ENSEMBL Gene Tree for MYT1 (if available)
    TreeFam Gene Tree for MYT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYT1 gene
    MYT1L2  ST182  
    2 SIMAP similar genes for MYT1 using alignment to 4 protein entries:     MYT1_HUMAN (see all proteins):
    MYT1L    ST18

    MYT1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MYT1
    PGOHUM00000239965


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYT1 (see all 2126)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs733247991,2
    C,F--62793860(+) AAACTG/CTTGTG 1 -- us2k12Minor allele frequency- C:0.06WA 120
    rs1408427081,2
    --62793981(+) CCTTGA/GGTGTC 1 -- us2k10--------
    rs4420831,2
    C,F,O,A,H--62794000(-) ATCAGC/GCTTAT 1 -- us2k130Minor allele frequency- N:0.00MN NS EA NA CSA WA 3462
    rs1501274291,2
    --62794027(+) CTTTGA/TTTCTG 1 -- us2k10--------
    rs1387636181,2
    --62794040(+) TTCATC/TATGGA 1 -- us2k10--------
    rs1404463331,2
    --62794051(+) ACAATC/GGCCCG 1 -- us2k10--------
    rs1932870361,2
    --62794064(+) AGCCTC/GCCCGG 1 -- us2k10--------
    rs1825627851,2
    --62794291(+) TTTGAC/GTAATT 1 -- us2k10--------
    rs1880300451,2
    --62794304(+) TATTTA/CATCCT 1 -- us2k10--------
    rs1145060831,2
    C,F--62794413(+) CGTATA/CAGAAT 1 -- us2k11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for MYT1 (62783144 - 62873606 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MYT1 (see all 26):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2097509CNV Deletion18987734
    esv2317556CNV Deletion18987734
    nsv821475CNV Deletion20802225
    esv1483804CNV Deletion17803354
    esv1552174CNV Deletion17803354
    esv1114131CNV Deletion17803354
    esv1005570CNV Deletion20482838
    esv1395726CNV Deletion17803354
    esv1143799CNV Deletion17803354
    esv1433479CNV Insertion17803354

    Human Gene Mutation Database (HGMD): MYT1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYT1
    DNA2.0 Custom Variant and Variant Library Synthesis for MYT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600379    OMIM disorders: --

    16 diseases for MYT1:    
    About MalaCards
    leukomalacia    periventricular leukomalacia    dysembryoplastic neuroepithelial tumor    sporadic breast cancer
    papillary thyroid carcinoma    sinusitis    mental retardation    pancreatic cancer
    thyroiditis    multiple sclerosis    pancreatitis    schizophrenia
    breast cancer    cervicitis    retinitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for MYT1:
    Dysembryoplastic neuroepithelial tumor

    MYT1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for MYT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukomalacia periventricular 60.1 4 12524179 (2)
    multiple sclerosis 17 1 17330875 (1)

    Genetic Association Database (GAD): MYT1
    Human Genome Epidemiology (HuGE) Navigator: MYT1 (3 documents)

    Export disorders for MYT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYT1 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with MYT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel member of the zinc finger superfamily: a C2-HC finger that recognizes a glia-specific gene. (PubMed id 1280325)1, 2, 3 Kim J.G. and Hudson L.D. (Mol. Cell. Biol. 1992)
    2. Expression of myelin transcription factor I (MyTI), a 'zinc-finger' DNA-binding protein, in developing oligodendrocytes. (PubMed id 8530187)1, 2, 9 Armstrong R.C.... Hudson L.D. (Glia 1995)
    3. Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells. (PubMed id 14962745)1, 2, 9 Nielsen J.A.... Armstrong R.C. (Mol. Cell. Neurosci. 2004)
    4. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    6. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    7. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    8. Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. (PubMed id 9268380)1, 3 Booher R.N.... Fattaey A. (J. Biol. Chem. 1997)
    9. Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS. (PubMed id 17330875)1, 9 Vana A.C....Armstrong R.C. (Glia 2007)
    10. Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia. (PubMed id 12524179)1, 9 Hirayama A....Takashima S. (Brain Res. Dev. Brain Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4661 HGNC: 7622 AceView: MYT1andC20orf36andLOC440773 Ensembl:ENSG00000196132 euGenes: HUgn4661
    ECgene: MYT1 H-InvDB: MYT1

    (According to HUGE)
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    HUGE: KIAA0835 KIAA1050

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MYT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MYT1 gene:
    Search GeneIP for patents involving MYT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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