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Aliases for MYT1 Gene

Aliases for MYT1 Gene

  • Myelin Transcription Factor 1 2 3 5
  • Neural Zinc Finger Transcription Factor 2 2 3
  • Myelin Transcription Factor I 3 4
  • PLPB1 3 4
  • MTF1 3 4
  • MYTI 3 4
  • Proteolipid Protein Binding Protein 3
  • Proteolipid Protein-Binding Protein 4
  • C20orf36 3
  • KIAA0835 4
  • KIAA1050 4
  • ZC2H2C1 3
  • ZC2HC4A 3
  • NZF2 3
  • MyT1 4

External Ids for MYT1 Gene

Previous HGNC Symbols for MYT1 Gene

  • PLPB1

Previous GeneCards Identifiers for MYT1 Gene

  • GC20P062673
  • GC20P063475
  • GC20P063522
  • GC20P062253
  • GC20P062266
  • GC20P062795
  • GC20P059521
  • GC20P062796

Summaries for MYT1 Gene

Entrez Gene Summary for MYT1 Gene

  • The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYT1 Gene

MYT1 (Myelin Transcription Factor 1) is a Protein Coding gene. Diseases associated with MYT1 include Periventricular Leukomalacia and Hemifacial Microsomia. Among its related pathways are Cyclins and Cell Cycle Regulation and Integrated Breast Cancer Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and enhancer sequence-specific DNA binding. An important paralog of this gene is MYT1L.

Gene Wiki entry for MYT1 Gene

Additional gene information for MYT1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYT1 Gene

Genomics for MYT1 Gene

Regulatory Elements for MYT1 Gene

Enhancers for MYT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H064220 1.6 Ensembl ENCODE dbSUPER 17.5 +71.2 71203 5 PKNOX1 ARNT ARID4B ZNF766 ZNF143 FOS SP5 REST ZNF592 KAT8 PCMTD2 MYT1 LINC00266-1 MIR647 GC20M064230 GC20P064162 GC20P064163
GH20H064188 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.6 +37.7 37711 1 PKNOX1 FOXA2 ATF1 ARID4B DMAP1 SLC30A9 ZNF143 ATF7 SP5 ZHX2 MYT1 PCMTD2 GC20P064162 GC20P064163 GC20M064230
GH20H064212 0.9 ENCODE dbSUPER 17.9 +61.0 61015 1 SAP130 MLX HLF BHLHE40 RAD21 ATF2 NFIL3 JUND ATF7 PCMTD2 MYT1 GC20M064230 GC20P064162 GC20P064163
GH20H064202 0.7 dbSUPER 18 +52.1 52079 3 CTCF MAZ ZBTB21 BACH1 KLF17 ZNF398 ATF2 ZFHX2 ZNF366 TARDBP MYT1 PCMTD2 OPRL1 GC20M064230 GC20P064163 GC20P064162
GH20H064206 0.5 ENCODE 18.8 +55.0 54950 0 SAP130 TEAD1 RAD21 TEAD3 MYT1 PCMTD2 GC20M064230 GC20P064163 GC20P064162
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MYT1 Gene

Chromosome:
20
Start:
64,151,791 bp from pter
End:
64,242,253 bp from pter
Size:
90,463 bases
Orientation:
Plus strand

Genomic View for MYT1 Gene

Genes around MYT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYT1 Gene

Proteins for MYT1 Gene

  • Protein details for MYT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01538-MYT1_HUMAN
    Recommended name:
    Myelin transcription factor 1
    Protein Accession:
    Q01538
    Secondary Accessions:
    • E1P5H0
    • F5H7M8
    • O94922
    • Q7Z5W2
    • Q9UPV2

    Protein attributes for MYT1 Gene

    Size:
    1121 amino acids
    Molecular mass:
    D Da
    Quaternary structure:
    No Data Available

neXtProt entry for MYT1 Gene

Post-translational modifications for MYT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYT1 Gene

No data available for DME Specific Peptides for MYT1 Gene

Domains & Families for MYT1 Gene

Gene Families for MYT1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MYT1 Gene

Suggested Antigen Peptide Sequences for MYT1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYT1: view

No data available for UniProtKB/Swiss-Prot for MYT1 Gene

Function for MYT1 Gene

Phenotypes From GWAS Catalog for MYT1 Gene

Gene Ontology (GO) - Molecular Function for MYT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 1280325
GO:0008270 zinc ion binding NAS 1280325
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MYT1: view
genes like me logo Genes that share phenotypes with MYT1: view

Animal Models for MYT1 Gene

MGI Knock Outs for MYT1:

Animal Model Products

CRISPR Products

miRNA for MYT1 Gene

miRTarBase miRNAs that target MYT1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYT1
  • Applied Biological Materials Clones for MYT1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYT1 Gene

Localization for MYT1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYT1 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MYT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 1280325
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MYT1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYT1 Gene

Pathways & Interactions for MYT1 Gene

genes like me logo Genes that share pathways with MYT1: view

Pathways by source for MYT1 Gene

Gene Ontology (GO) - Biological Process for MYT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 1280325
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with MYT1: view

No data available for SIGNOR curated interactions for MYT1 Gene

Drugs & Compounds for MYT1 Gene

(1) Drugs for MYT1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MYT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MYT1: view

Transcripts for MYT1 Gene

Unigene Clusters for MYT1 Gene

Myelin transcription factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYT1
  • Applied Biological Materials Clones for MYT1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MYT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c · 22d ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP8: - -
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

ExUns: 22e ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b · 30c · 30d
SP1:
SP2:
SP3: - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - - - - - - - - - -
SP7: - -
SP8: - -
SP9:
SP10: - -
SP11:
SP12: -
SP13:
SP14:
SP15: - -
SP16:

Relevant External Links for MYT1 Gene

GeneLoc Exon Structure for
MYT1
ECgene alternative splicing isoforms for
MYT1

Expression for MYT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYT1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x14.9) and Brain - Cerebellum (x13.9).

Protein differential expression in normal tissues from HIPED for MYT1 Gene

This gene is overexpressed in Retina (35.0), Platelet (19.2), and NK cells (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYT1 Gene



Protein tissue co-expression partners for MYT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MYT1 Gene:

MYT1

SOURCE GeneReport for Unigene cluster for MYT1 Gene:

Hs.279562

Evidence on tissue expression from TISSUES for MYT1 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with MYT1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYT1 Gene

Orthologs for MYT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYT1 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYT1 33 34
  • 88.32 (n)
cow
(Bos Taurus)
Mammalia MYT1 33 34
  • 88.08 (n)
rat
(Rattus norvegicus)
Mammalia Myt1 33
  • 87.52 (n)
mouse
(Mus musculus)
Mammalia Myt1 33 16 34
  • 86.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYT1 34
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYT1 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYT1 33 34
  • 79.14 (n)
lizard
(Anolis carolinensis)
Reptilia MYT1 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490628 33
  • 75.98 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397982 33
zebrafish
(Danio rerio)
Actinopterygii myt1a 33 34
  • 71.52 (n)
myt1b 34
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43689 34
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ztf-11 34
  • 18 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.17722 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 18 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8435 33
Species where no ortholog for MYT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYT1 Gene

ENSEMBL:
Gene Tree for MYT1 (if available)
TreeFam:
Gene Tree for MYT1 (if available)

Paralogs for MYT1 Gene

Paralogs for MYT1 Gene

(2) SIMAP similar genes for MYT1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for MYT1 Gene

genes like me logo Genes that share paralogs with MYT1: view

Variants for MYT1 Gene

Sequence variations from dbSNP and Humsavar for MYT1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000014079 -- 64,176,848(+) CCTGT(C/T)GGCAG intron-variant
rs1000023345 -- 64,211,461(+) GTTTG(C/T)CCAGA intron-variant
rs1000031556 -- 64,182,445(+) CCTGA(C/T)ATAGC intron-variant
rs1000061962 -- 64,230,381(+) GGTGG(C/T)GGGCG intron-variant
rs1000123445 -- 64,218,733(+) GGCCC(A/T)CCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYT1 Gene

Variant ID Type Subtype PubMed ID
dgv2454e59 CNV duplication 20981092
dgv4347n100 CNV gain 25217958
dgv4348n100 CNV gain 25217958
esv1005570 CNV deletion 20482838
esv1049699 CNV insertion 17803354
esv1114131 CNV deletion 17803354
esv1143799 CNV deletion 17803354
esv1395726 CNV deletion 17803354
esv1433479 CNV insertion 17803354
esv1483804 CNV deletion 17803354
esv1552174 CNV deletion 17803354
esv2097509 CNV deletion 18987734
esv2317556 CNV deletion 18987734
esv23921 CNV gain+loss 19812545
esv24888 CNV loss 19812545
esv2559642 CNV insertion 19546169
esv2758807 CNV gain+loss 17122850
esv3568101 CNV loss 25503493
esv3646333 CNV loss 21293372
esv3646334 CNV gain 21293372
esv3646335 CNV gain 21293372
esv3646336 CNV gain 21293372
nsv1064470 CNV gain 25217958
nsv1067529 CNV gain 25217958
nsv1071718 CNV deletion 25765185
nsv1114238 CNV deletion 24896259
nsv1116883 CNV deletion 24896259
nsv1119653 CNV deletion 24896259
nsv1125223 CNV insertion 24896259
nsv1125959 CNV deletion 24896259
nsv1130775 CNV deletion 24896259
nsv1137535 CNV deletion 24896259
nsv1142316 CNV tandem duplication 24896259
nsv1143214 CNV deletion 24896259
nsv1143217 CNV deletion 24896259
nsv1143998 CNV deletion 24896259
nsv1148380 CNV deletion 26484159
nsv1151679 CNV deletion 26484159
nsv1153326 CNV deletion 26484159
nsv179382 CNV deletion 16902084
nsv179519 CNV deletion 16902084
nsv428381 CNV gain+loss 18775914
nsv470564 CNV gain 18288195
nsv524962 CNV loss 19592680
nsv527137 CNV loss 19592680
nsv586863 CNV loss 21841781
nsv821475 CNV deletion 20802225
nsv9833 CNV gain 18304495

Variation tolerance for MYT1 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYT1 Gene

Human Gene Mutation Database (HGMD)
MYT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYT1 Gene

Disorders for MYT1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MYT1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
periventricular leukomalacia
  • pvl
hemifacial microsomia
  • goldenhar syndrome
leukomalacia
encephalomalacia
- elite association - COSMIC cancer census association via MalaCards
Search MYT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYT1

Genetic Association Database (GAD)
MYT1
Human Genome Epidemiology (HuGE) Navigator
MYT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYT1
genes like me logo Genes that share disorders with MYT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYT1 Gene

Publications for MYT1 Gene

  1. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PMID: 18950845) Vega A … Carracedo A (Gynecologic oncology 2009) 3 45 60
  2. Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS. (PMID: 17330875) Vana AC … Armstrong RC (Glia 2007) 3 22 60
  3. Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells. (PMID: 14962745) Nielsen JA … Armstrong RC (Molecular and cellular neurosciences 2004) 3 22 60
  4. Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia. (PMID: 12524179) Hirayama A … Takashima S (Brain research. Developmental brain research 2003) 3 22 60
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 60

Products for MYT1 Gene

  • Addgene plasmids for MYT1

Sources for MYT1 Gene

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