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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYT1 Gene

protein-coding   GIFtS: 56
GCID: GC20P062795

myelin transcription factor 1


(Previous symbol: PLPB1)
 Explore 13 diseases affiliated with
MYT1 via our new
 Human Malady Compendium 
Biological research products
for MYT1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Myelin Transcription Factor 11 2     C20orf362
PLPB11 2 3 5     Proteolipid Protein Binding Protein2
MTF11 2 3     KIAA08353
MYTI1 2 3     KIAA10503
ZC2HC4A1 2     MyT13
Myelin Transcription Factor I2 3     MyTI3
Proteolipid Protein-Binding Protein2 3     

External Ids:    HGNC: 76221   Entrez Gene: 46612   Ensembl: ENSG000001961327   OMIM: 6003795   UniProtKB: Q015383   

Export aliases for MYT1 gene to outside databases

Previous GC identifers: GC20P062673 GC20P063475 GC20P063522 GC20P062253 GC20P062266 GC20P059521


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYT1:
The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding
proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a
role in the developing nervous system. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MYT1_HUMAN, Q01538
Function: Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the
development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte
lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and
up-regulation of myelin gene transcription

Gene Wiki entry for MYT1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYT1 gene promoter:
         HFH-3   MyoD   HNF-3beta   C/EBPalpha   CREB   FOXI1   POU2F1   POU2F1a   deltaCREB   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MYT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

MYT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYT1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P062795:  view genomic region     (about GC identifiers)

Start:
62,783,144 bp from pter      End:
62,873,606 bp from pter
Size:
90,463 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MYT1_HUMAN, Q01538 (See protein sequence)
Recommended Name: Myelin transcription factor 1  
Size: 1121 amino acids; 122329 Da
Subunit: Interacts with STEAP3
Subcellular location: Nucleus
Sequence caution: Sequence=BAA74858.2; Type=Erroneous initiation;
Secondary accessions: E1P5H0 O94922 Q9UPV2

Explore the universe of human proteins at neXtProt for MYT1: NX_Q01538

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q01538

  • MYT1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004526.1  
    ENSEMBL proteins: 
     ENSP00000327465   ENSP00000442412   ENSP00000353269  

    Human Recombinant Protein Products: 
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    Novus Biologicals MYT1 Protein
    Novus Biologicals MYT1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MYT1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS1280325


    MYT1 for ontologies           About GeneDecksing



    MYT1 Antibody Products: 
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    Uscn Antibodies for MYT1
    ThermoFisher Antibodies for MYT1

    Assay Products for MYT1: 
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    Uscn ELISAs and CLIAs for MYT1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MYT1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002515 Znf_C2HC
     IPR013681 Myelin_TF

    Graphical View of Domain Structure for InterPro Entry Q01538

    ProtoNet protein and cluster: Q01538

    1 Blocks protein family: IPB013681 Myelin transcription factor 1

    UniProtKB/Swiss-Prot: MYT1_HUMAN, Q01538
    Domain: Contains 7 zinc fingers of the C2HC class arranged in two widely separated clusters. These two domains of DNA
    binding can function independently and recognize the same DNA sequence
    Similarity: Contains 7 C2HC-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MYT1_HUMAN, Q01538
    Function: Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the
    development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte
    lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and
    up-regulation of myelin gene transcription

    miRNA
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    miRTarBase miRNAs that target MYT1:
    hsa-mir-27a (MIRT001770)

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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYT1
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate MYT1 (see all 53):
    hsa-miR-429 hsa-miR-146a hsa-miR-128 hsa-miR-16-1* hsa-miR-301a hsa-miR-138-2* hsa-miR-519a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidMYT1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYT1 (see all 7)
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    OriGene siRNA: MYT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYT1

    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYT1 

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    Search LifeMap BioReagents cell lines for MYT1

    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYT1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS1280325
    GO:0005515protein binding ----
    GO:0008270zinc ion binding NAS1280325


    MYT1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MYT1:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Myt1tm1.1Ggu for MYT1
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Myt1):
     endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  muscle 

    MYT1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway1.00
    Integrated Pancreatic Cancer Pathway0.99
    2Mitotic Roles of Polo Like Kinases
    Mitotic Roles of Polo Like Kinases1.00
    3Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway1.00
    4Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation1.00
    5Cell cycle
    G1 to S cell cycle control0.38

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYT1
        Cyclins and Cell Cycle Regulation
    Mitotic Roles of Polo Like Kinases

    4 BioSystems Pathways for MYT1 
        Integrated Breast Cancer Pathway
    G1 to S cell cycle control
    Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/8 Interacting proteins for MYT1 (Q015383 ENSP000003274654) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIN3BO751823, ENSP000003691314I2D: score=2 STRING: ENSP00000369131
    PIN1Q135263, ENSP000002479704I2D: score=3 STRING: ENSP00000247970
    PLK1P533503, ENSP000003000934I2D: score=2 STRING: ENSP00000300093
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    CDK1P064933I2D: score=3 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS1280325
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--


    MYT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MYT1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MYT1
    3 Novoseek chemical compound relationships for MYT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepa 73.5 2 9111349 (1), 9507026 (1)
    zinc 52.1 28 9507026 (10), 9111349 (3), 9478997 (2), 14962745 (1) (see all 6)
    cadmium 27 11 9507026 (8)

    Search CenterWatch for drugs/clinical trials and news about MYT1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYT1 gene: 
    NM_004535.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328439(uc002yii.3) ENST00000536311(uc002yij.3) ENST00000360149(uc002yih.3)


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYT1
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate MYT1 (see all 53):
    hsa-miR-429 hsa-miR-146a hsa-miR-128 hsa-miR-16-1* hsa-miR-301a hsa-miR-138-2* hsa-miR-519a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidMYT1 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYT1 (see all 7)
    OriGene shRNA RFP: MYT1
    OriGene siRNA: MYT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYT1
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYT1 (see all 6)
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    GenScript: all cDNA clones in your preferred vector: MYT1 (NM_004535)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYT1 
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYT1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYT1

    24/296 AceView cDNA sequences (see all 296):

    AW089296 NM_004535 N48465 BM703758 T28784 R98114 C01016 BX093993 
    CR603851 BM996236 AI078224 BE327085 BU509848 BM681588 AK126700 N40581 
    AA150338 CA776650 BQ015848 CR613817 AA424320 BQ640685 BM666299 T06192 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MYT1 (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c · 22d ·
    SP1:        -     -     -     -     -           -                                                                                                               
    SP2:        -     -     -     -     -           -                             -                                                                                 
    SP3:                                                                                                                    -     -     -     -                     
    SP4:                                                                                                                    -     -     -     -                     
    SP5:                                                                                                                    -     -     -     -                 -   

    ExUns: 22e ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b · 30c · 30d
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:        -     -                                   -     -           -                           
    SP4:        -     -                                   -                 -                           
    SP5:  -     -     -     -                             -                 -                           


    ECgene alternative splicing isoforms for MYT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    MYT1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeRetinaEye
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MYT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYT1

    UniProtKB/Swiss-Prot: MYT1_HUMAN, Q01538
    Tissue specificity: Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage
    cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MYT1 gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves MYT11 myelin transcription factor 1 78.74(n)
    83.11(a)
      419249  XM_417423.3  XP_417423.3 
    lizard
    (Anolis carolinensis)
    Reptilia MYT16
    --
    83(a)
    1 ↔ 1
    4(154535296-154594614)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979822 C2-HC type zinc finger protein X-MyT1 76.92(n)    U67078.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myt1a1 myelin transcription factor 1a 65.88(n)
    64.64(a)
      557002  XM_679958.5  XP_685050.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG436896
    --
    12(a)
    1 → many
    X(3970107-3986186)
    worm
    (Caenorhabditis elegans)
    Secernentea ztf-116
    Zinc finger Transcription Factor family member (zt...
    21(a)
    1 → many
    I(9904294-9910536)
    soybean
    (Glycine max)
    eudicotyledons Gma.177222 Transcribed sequence with weak similarity to protein more 74.38(n)  


    ENSEMBL Gene Tree for MYT1 (if available)
    TreeFam Gene Tree for MYT1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYT1 gene
    MYT1L2  ST182  
    2 SIMAP similar genes for MYT1 using alignment to 4 protein entries:     MYT1_HUMAN (see all proteins):
    MYT1L    ST18

    MYT1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MYT1
    PGOHUM00000239965


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1734 NCBI SNPs in MYT1 are shown (see all 1734    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs733247991,2
    C,--62793860(+) AAACTG/CTTGTG 1 -- us2k12Minor allele frequency- C:0.06WA 120
    rs1408427081,2
    --62793981(+) CCTTGA/GGTGTC 1 -- us2k10--------
    rs4420831,2
    C,F,O,A,H,--62794000(-) ATCAGC/GCTTAT 1 -- us2k130Minor allele frequency- N:0.00MN NS EA NA CSA WA 3462
    rs1501274291,2
    --62794027(+) CTTTGA/TTTCTG 1 -- us2k10--------
    rs1387636181,2
    --62794040(+) TTCATC/TATGGA 1 -- us2k10--------
    rs1404463331,2
    --62794051(+) ACAATC/GGCCCG 1 -- us2k10--------
    rs1932870361,2
    --62794064(+) AGCCTC/GCCCGG 1 -- us2k10--------
    rs1825627851,2
    --62794291(+) TTTGAC/GTAATT 1 -- us2k10--------
    rs1880300451,2
    --62794304(+) TATTTA/CATCCT 1 -- us2k10--------
    rs1145060831,2
    C,F,--62794413(+) CGTATA/CAGAAT 1 -- us2k11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for MYT1 (62783144 - 62873606 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 14 variations for MYT1
         5 CNVs: 73584 31049 4108 34483 73585
         9 Indels: 90664 103031 46136 90665 79285 26915 12227 26916 46137
    Human Gene Mutation Database (HGMD): MYT1

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MYT1 for disorders           About GeneDecksing

    OMIM gene information: 600379    OMIM disorders: --

    13 diseases for MYT1:    About MalaCards
    dysembryoplastic neuroepithelial tumor    periventricular leukomalacia    leukomalacia    papillary thyroid carcinoma
    sporadic breast cancer    thyroid carcinoma    skin cancer    breast cancer
    thyroiditis    carcinoma    schizophrenia    pancreatitis
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for MYT1:
    Dysembryoplastic neuroepithelial tumor

    2 Novoseek disease relationships for MYT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukomalacia periventricular 60.1 4 12524179 (2)
    multiple sclerosis 17 1 17330875 (1)

    Human Genome Epidemiology (HuGE) Navigator: MYT1 (3 documents)

    Export disorders for MYT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYT1 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with MYT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel member of the zinc finger superfamily: a C2-HC finger that recognizes a glia-specific gene. (PubMed id 1280325)1, 2, 3 Kim J.G. and Hudson L.D. (1992)
    2. Expression of myelin transcription factor I (MyTI), a 'zinc-finger' DNA-binding protein, in developing oligodendrocytes. (PubMed id 8530187)1, 2, 9 Armstrong R.C.... Hudson L.D. (1995)
    3. Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells. (PubMed id 14962745)1, 2, 9 Nielsen J.A.... Armstrong R.C. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    5. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
    6. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
    7. Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. (PubMed id 9268380)1, 3 Booher R.N....Fattaey A. (1997)
    8. Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS. (PubMed id 17330875)1, 9 Vana A.C....Armstrong R.C. (2007)
    9. Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia. (PubMed id 12524179)1, 9 Hirayama A....Takashima S. (2003)
    10. Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. (PubMed id 9373037)1, 9 Kim J.G....Hudson L.D. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4661 HGNC: 7622 AceView: MYT1andC20orf36andLOC440773 Ensembl:ENSG00000196132 euGenes: HUgn4661
    ECgene: MYT1 H-InvDB: MYT1

    (According to HUGE)
    About This Section
    HUGE: KIAA0835 KIAA1050

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYT1 gene:
    Search GeneIP for patents involving MYT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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