Aliases for MYSM1 Gene
External Ids for MYSM1 Gene
GeneCards Summary for MYSM1 Gene
MYSM1 (Myb-Like, SWIRM And MPN Domains 1) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and ubiquitin thiolesterase activity. An important paralog of this gene is MPND.
UniProtKB/Swiss-Prot for MYSM1 Gene
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.