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MYRIP Gene

protein-coding   GIFtS: 54
GCID: GC03P039826

Myosin VIIA And Rab Interacting Protein

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin VIIA And Rab Interacting Protein1 2     Slp Homolog Lacking C2 Domains C2 3
SLAC2C2 3 5     Synaptotagmin-Like Protein Lacking C2 Domains C2 3
Rab Effector MYRIP1 2     SLAC2-C2
Slp Homologue Lacking C2 Domains1 2     exophilin-82
Synaptotagmin-Like Protein Homologue Lacking C2 Domains-C1 2     Exophilin-83
Myosin-VIIa- And Rab-Interacting Protein2 3     SlaC2-c3

External Ids:    HGNC: 191561   Entrez Gene: 259242   Ensembl: ENSG000001700117   OMIM: 6117905   UniProtKB: Q8NFW93   

Export aliases for MYRIP gene to outside databases

Previous GC identifers: GC03P039190 GC03P039084 GC03P039664 GC03P039811


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYRIP Gene:
MYRIP (myosin VIIA and Rab interacting protein) is a protein-coding gene. GO annotations related to this gene include actin binding and myosin binding. An important paralog of this gene is MLPH.

UniProtKB/Swiss-Prot: MYRIP_HUMAN, Q8NFW9
Function: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A
and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a
protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the
exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYRIP gene promoter:
         AhR   Max1   Tal-1   XBP-1   E47   Arnt   CBF-B   CBF-A   c-Myc   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MYRIP promoter sequence
   Search Chromatin IP Primers for MYRIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYRIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p21.33

MYRIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYRIP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P039826:  view genomic region     (about GC identifiers)

Start:
39,850,405 bp from pter      End:
40,301,812 bp from pter
Size:
451,408 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MYRIP_HUMAN, Q8NFW9 (See protein sequence)
Recommended Name: Rab effector MyRIP  
Size: 859 amino acids; 95706 Da
Subunit: Binds MYO5A, MYO7A and F-actin (By similarity). Binds RAB27A that has been activated by GTP-binding via
its N-terminus. Interacts with PRKAR2A. Interacts with components of the exocyst complex, including EXOC3 and
EXOC4 (By similarity)
Secondary accessions: B3KWM3 B3KWW4 B7Z2H1 B7Z9V3 G3XAI8 Q32M41 Q569F7 Q8IUF5 Q9Y3V4
Alternative splicing: 5 isoforms:  Q8NFW9-1   Q8NFW9-2   Q8NFW9-3   Q8NFW9-4   Q8NFW9-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYRIP: NX_Q8NFW9

Explore proteomics data for MYRIP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYRIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001271352.1  NP_001271353.1  NP_001271354.1  NP_001271355.1  NP_056275.2  

    ENSEMBL proteins: 
     ENSP00000398665   ENSP00000301972   ENSP00000389323   ENSP00000400916   ENSP00000413392  
     ENSP00000379519   ENSP00000438297  

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    antibodies-online peptides for MYRIP

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    antibodies-online antibodies for MYRIP (32 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AKAP: A-kinase anchor proteins

    4 InterPro protein domains:
     IPR006788 Myrip/Melanophilin
     IPR013083 Znf_RING/FYVE/PHD
     IPR010911 Znf_FYVE-typ
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q8NFW9

    ProtoNet protein and cluster: Q8NFW9

    1 Blocks protein domain: IPB000306 Zn-finger

    UniProtKB/Swiss-Prot: MYRIP_HUMAN, Q8NFW9
    Similarity: Contains 1 FYVE-type zinc finger
    Similarity: Contains 1 RabBD (Rab-binding) domain


    Find genes that share domains with MYRIP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYRIP_HUMAN, Q8NFW9
    Function: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A
    and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a
    protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the
    exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI11964381
    GO:0008270zinc ion binding NAS11964381
    GO:0017022myosin binding ----
    GO:0017137Rab GTPase binding IEA--
         
    Find genes that share ontologies with MYRIP           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MYRIP

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MYRIP (see all 62):
    hsa-miR-194* hsa-miR-579 hsa-let-7d hsa-miR-15a hsa-miR-200a hsa-miR-650 hsa-miR-449a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidMYRIP 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYRIP_HUMAN, Q8NFW9: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Cytoplasmic
    vesicle, secretory vesicle (By similarity). Note=In presynaptic and postsynaptic areas in photoreceptor cells and
    in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin
    filaments (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000145exocyst IEA--
    GO:0001750photoreceptor outer segment IEA--
    GO:0015629actin cytoskeleton IEA--
    GO:0030133transport vesicle IEA--
    GO:0031045dense core granule ISS--

    Find genes that share ontologies with MYRIP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYRIP About    
    See pathways by source

    SuperPathContained pathways About
    1Deregulation of Rab and Rab Effector Genes in Bladder Cancer
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    1 BioSystems Pathway for MYRIP
        Deregulation of Rab and Rab Effector Genes in Bladder Cancer


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYRIP
    Interactions:

        GeneGlobe Interaction Network for MYRIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for MYRIP (Q8NFW92, 3 ENSP000003019724) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-8112123 I2D: score=3 STRING: ENSP00000274335
    MYO7AQ134023, ENSP000003863314I2D: score=1 STRING: ENSP00000386331
    RAB27AP511593, ENSP000003377614I2D: score=3 STRING: ENSP00000337761
    NCK1P163333, ENSP000002889864I2D: score=2 STRING: ENSP00000288986
    GRB2P629933, ENSP000003390074I2D: score=2 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0032024positive regulation of insulin secretion ISS--

    Find genes that share ontologies with MYRIP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYRIP

    1 HMDB Compound for MYRIP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYRIP gene (5 alternative transcripts): 
    NM_001284423.1  NM_001284424.1  NM_001284425.1  NM_001284426.1  NM_015460.3  

    Unigene Cluster for MYRIP:

    Myosin VIIA and Rab interacting protein
    Hs.594535  [show with all ESTs]
    Unigene Representative Sequence: BC092512
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444716 ENST00000302541(uc003cka.3 uc010hhu.3 uc010hhv.3 uc010hhw.3 uc011ayz.2)
    ENST00000425621 ENST00000458441 ENST00000458292 ENST00000475082(uc010hhx.1)
    ENST00000459828 ENST00000482033 ENST00000396217 ENST00000539167
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    Selected qRT-PCR Assays for microRNAs that regulate MYRIP (see all 62):
    hsa-miR-194* hsa-miR-579 hsa-let-7d hsa-miR-15a hsa-miR-200a hsa-miR-650 hsa-miR-449a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidMYRIP 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat MYRIP

    Additional mRNA sequence: 

    AB083783.1 AF396687.1 AK125334.1 AK126013.1 AK294714.1 AK310972.1 AK312412.1 AK316068.1 
    AL050090.1 BC092512.1 BC109311.1 BC109312.1 

    6 DOTS entries:

    DT.411498  DT.99954773  DT.120871429  DT.439321  DT.40246508  DT.75104804 

    Selected AceView cDNA sequences (see all 51):

    AI827924 AB083783 AA323164 AA579870 Z45990 F01507 F07858 AL050090 
    AW594282 AA455367 AW237186 AW665105 AA258345 BF478223 AA974678 AA195295 
    AA258393 F04955 AW451104 AK126013 BM680913 AF396687 NM_015460 AI434843 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MYRIP    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
    SP1:              -                                                                                                         
    SP2:              -                                                     -                                                   
    SP3:                                                                                                                        
    SP4:              -     -                                                                                                   
    SP5:              -                                                     -     -                                             


    ECgene alternative splicing isoforms for MYRIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYRIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATATGCAC
    MYRIP Expression
    About this image


    MYRIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
             Human umbilical vein endothelial cells (HUVEC)
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
             Midbrain dopaminergic-like neurons
     
     Neurons
             Midbrain dopaminergic-like neurons
     
     Dopaminergic Neurons (Nervous System)
             Midbrain dopaminergic-like neurons
    MYRIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYRIP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.594535

    UniProtKB/Swiss-Prot: MYRIP_HUMAN, Q8NFW9
    Tissue specificity: Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle
    and testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYRIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MYRIP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myrip1 , 5 myosin VIIA and Rab interacting protein1, 5 81.77(n)1
    80.33(a)1
      9 (71.50 cM)5
    2450491  NM_144557.51  NP_653140.11 
     1203039365 
    chicken
    (Gallus gallus)
    Aves MYRIP1 myosin VIIA and Rab interacting protein 69.15(n)
    66.86(a)
      428455  XM_426015.4  XP_426015.3 
    lizard
    (Anolis carolinensis)
    Reptilia MYRIP6
    myosin VIIA and Rab interacting protein
    64(a)
    1 ↔ 1
    GL343224.1(1658224-1862166)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia myrip1 myosin VIIA and Rab interacting protein 64.27(n)
    63.4(a)
      100490150  XM_002938306.2  XP_002938352.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myrip1 myosin VIIA and Rab interacting protein 59.57(n)
    56.4(a)
      567049  XM_690337.5  XP_695429.5 


    ENSEMBL Gene Tree for MYRIP (if available)
    TreeFam Gene Tree for MYRIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYRIP gene
    MLPH2  
    3 SIMAP similar genes for MYRIP using alignment to 3 protein entries:     MYRIP_HUMAN (see all proteins):
    MLPH    MOBP    SYTL4

    Find genes that share paralogs with MYRIP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYRIP (see all 7104)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs170796591,2
    C,F,H--39849329(+) TTGACA/GTTATC 1 -- us2k117Minor allele frequency- G:0.08NA NS EA WA CSA 1228
    rs1819978551,2
    --39849333(+) CATTAC/TCCAAA 1 -- us2k10--------
    rs1850063221,2
    --39849348(+) AAATGC/TACATC 1 -- us2k10--------
    rs98647681,2
    C,F,H--39849382(+) gtacaG/Tattta 1 -- us2k115Minor allele frequency- T:0.14NS EA NA CSA WA 1206
    rs1394841691,2
    --39849403(+) GTACCC/TCCACA 1 -- us2k10--------
    rs1496915501,2
    --39849444(+) CATGCA/GTAATT 1 -- us2k10--------
    rs1445098111,2
    C--39849653(+) TTGTAC/TAACAA 1 -- us2k10--------
    rs763215941,2
    C--39849704(+) TGTCAA/CTTTCC 1 -- us2k10--------
    rs786010611,2
    C--39849705(+) GTCAAA/TTTCCT 1 -- us2k10--------
    rs743619151,2
    C--39849708(+) AATTTA/CCTTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MYRIP (39850405 - 40100405 bp, first 250kb of MYRIP)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MYRIP (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725187CNV Deletion23290073
    esv2725184CNV Deletion23290073
    esv2725186CNV Deletion23290073
    esv2725181CNV Deletion23290073
    esv2663421CNV Deletion23128226
    esv2656601CNV Deletion23128226
    esv2725182CNV Deletion23290073
    esv4522CNV Deletion18987735
    esv2725183CNV Deletion23290073
    esv1407814CNV Insertion17803354

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611790    OMIM disorders: --


    Find genes that share disorders with MYRIP           About GenesLikeMe

    Genetic Association Database (GAD): MYRIP
    Human Genome Epidemiology (HuGE) Navigator: MYRIP (2 documents)

    Export disorders for MYRIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYRIP gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with MYRIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin. (PubMed id 12221080)1, 2, 3, 9 Fukuda M. and Kuroda T.S. (J. Biol. Chem. 2002)
    2. MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes. (PubMed id 11964381)1, 2, 3 El-Amraoui A.... Petit C. (EMBO Rep. 2002)
    3. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PubMed id 21130836)1, 4 Luciano M....Deary I.J. (Biol Psychol 2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. MyRIP anchors protein kinase A to the exocyst complex. (PubMed id 17827149)1, 2 Goehring A.S.... Scott J.D. (J. Biol. Chem. 2007)
    6. Genome-wide association of sleep and circadian phenotypes. (PubMed id 17903308)1, 4 Gottlieb D.J....Wilk J.B. (BMC Med. Genet. 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. (PubMed id 23007406)1 Yang J.J....Relling M.V. (Blood 2012)
    9. Myrip couples the capture of secretory granules by the actin-rich cell cortex and their attachment to the plasma membrane. (PubMed id 22396429)1 Huet S....Desnos C. (J. Neurosci. 2012)
    10. Myosin Va acts in concert with Rab27a and MyRIP to regulate acute von-Willebrand factor release from endothelial cells. (PubMed id 21740491)1 Rojo Pulido I....Gerke V. (Traffic 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25924 HGNC: 19156 AceView: MYRIP Ensembl:ENSG00000170011 euGenes: HUgn25924
    ECgene: MYRIP H-InvDB: MYRIP

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MYRIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYRIP gene:
    Search GeneIP for patents involving MYRIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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