Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYRIP Gene

protein-coding   GIFtS: 55
GCID: GC03P039826

Myosin VIIA And Rab Interacting Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Myosin VIIA And Rab Interacting Protein1 2     Slp Homolog Lacking C2 Domains C2 3
SLAC2C2 3 5     Synaptotagmin-Like Protein Lacking C2 Domains C2 3
Rab Effector MYRIP1 2     SLAC2-C2
Slp Homologue Lacking C2 Domains1 2     exophilin-82
Synaptotagmin-Like Protein Homologue Lacking C2 Domains-C1 2     Exophilin-83
Myosin-VIIa- And Rab-Interacting Protein2 3     SlaC2-c3

External Ids:    HGNC: 191561   Entrez Gene: 259242   Ensembl: ENSG000001700117   OMIM: 6117905   UniProtKB: Q8NFW93   

Export aliases for MYRIP gene to outside databases

Previous GC identifers: GC03P039190 GC03P039084 GC03P039664 GC03P039811


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MYRIP Gene: 
MYRIP (myosin VIIA and Rab interacting protein) is a protein-coding gene. Diseases associated with MYRIP include age related macular degeneration, and macular degeneration. GO annotations related to this gene include protein kinase A binding and actin binding. An important paralog of this gene is MLPH.

UniProtKB/Swiss-Prot: MYRIP_HUMAN, Q8NFW9
Function: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A
and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a
protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the
exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYRIP gene promoter:
         AhR   Max1   Tal-1   XBP-1   E47   Arnt   CBF-B   CBF-A   c-Myc   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MYRIP promoter sequence
   Search SABiosciences Chromatin IP Primers for MYRIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYRIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p21.33

MYRIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYRIP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P039826:  view genomic region     (about GC identifiers)

Start:
39,850,405 bp from pter      End:
40,301,812 bp from pter
Size:
451,408 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MYRIP_HUMAN, Q8NFW9 (See protein sequence)
Recommended Name: Rab effector MyRIP  
Size: 859 amino acids; 95706 Da
Subunit: Binds MYO5A, MYO7A and F-actin (By similarity). Binds RAB27A that has been activated by GTP-binding via
its N-terminus. Interacts with PRKAR2A. Interacts with components of the exocyst complex, including EXOC3 and
EXOC4 (By similarity)
Subcellular location: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Cytoplasmic
vesicle, secretory vesicle (By similarity). Note=In presynaptic and postsynaptic areas in photoreceptor cells and
in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin
filaments (By similarity)
Secondary accessions: B3KWM3 B3KWW4 B7Z2H1 B7Z9V3 G3XAI8 Q32M41 Q569F7 Q8IUF5 Q9Y3V4
Alternative splicing: 5 isoforms:  Q8NFW9-1   Q8NFW9-2   Q8NFW9-3   Q8NFW9-4   Q8NFW9-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYRIP: NX_Q8NFW9

Explore proteomics data for MYRIP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NFW9

  • MYRIP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYRIP Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001271352.1  NP_001271353.1  NP_001271354.1  NP_001271355.1  NP_056275.2  

    ENSEMBL proteins: 
     ENSP00000398665   ENSP00000301972   ENSP00000389323   ENSP00000400916   ENSP00000413392  
     ENSP00000379519   ENSP00000438297  

    Human Recombinant Protein Products for MYRIP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MYRIP
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MYRIP
    GenScript Custom Purified and Recombinant Proteins Services for MYRIP
    Novus Biologicals MYRIP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYRIP 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000145exocyst IEA--
    GO:0001750photoreceptor outer segment IEA--
    GO:0015629actin cytoskeleton IEA--
    GO:0030133transport vesicle IEA--
    GO:0031045dense core granule ISS--

    MYRIP for ontologies           About GeneDecksing



    MYRIP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MYRIP
    OriGene Custom Antibody Services for MYRIP
    GenScript Custom Superior Antibodies Services for MYRIP
    Novus Biologicals MYRIP Antibodies
    Search for Antibodies for MYRIP at Abcam
    Cloud-Clone Corp. Antibodies for MYRIP 
    ThermoFisher Antibodies for MYRIP
    LSBio Antibodies in human, mouse, rat for MYRIP 

    Assay Products for MYRIP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MYRIP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYRIP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYRIP 
    Cloud-Clone Corp. CLIAs for MYRIP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    AKAP: A-kinase anchor proteins

    4 InterPro protein domains:
     IPR006788 Myrip/Melanophilin
     IPR013083 Znf_RING/FYVE/PHD
     IPR010911 Rab-bd_domain
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q8NFW9

    ProtoNet protein and cluster: Q8NFW9

    1 Blocks protein domain: IPB000306 Zn-finger

    UniProtKB/Swiss-Prot: MYRIP_HUMAN, Q8NFW9
    Similarity: Contains 1 FYVE-type zinc finger
    Similarity: Contains 1 RabBD (Rab-binding) domain


    MYRIP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYRIP_HUMAN, Q8NFW9
    Function: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A
    and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a
    protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the
    exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI11964381
    GO:0008270zinc ion binding NAS11964381
    GO:0017022myosin binding IEA--
    GO:0017137Rab GTPase binding IEA--
         
    MYRIP for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MYRIP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MYRIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYRIP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYRIP 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYRIP
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate MYRIP (see all 62):
    hsa-miR-194* hsa-miR-579 hsa-let-7d hsa-miR-15a hsa-miR-200a hsa-miR-650 hsa-miR-449a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidMYRIP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MYRIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYRIP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYRIP
    Sirion Biotech Customized adenovirus for overexpression of MYRIP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MYRIP (see all 7)
    OriGene ORF clones in mouse, rat for MYRIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYRIP (NM_015460)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYRIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYRIP
    Sirion Biotech Customized lentivirus for stable overexpression of MYRIP 
                         Customized lentivirus expression plasmids for stable overexpression of MYRIP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MYRIP
    Search LifeMap BioReagents cell lines for MYRIP
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYRIP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MYRIP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deregulation of Rab and Rab Effector Genes in Bladder Cancer
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    1 BioSystems Pathway for MYRIP
        Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYRIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/8 Interacting proteins for MYRIP (Q8NFW92, 3 ENSP000003019724) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-8112123 I2D: score=3 STRING: ENSP00000274335
    MYO7AQ134023, ENSP000003863314I2D: score=1 STRING: ENSP00000386331
    RAB27AP511593, ENSP000003377614I2D: score=3 STRING: ENSP00000337761
    NCK1P163333, ENSP000002889864I2D: score=2 STRING: ENSP00000288986
    GRB2P629933, ENSP000003390074I2D: score=2 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0032024positive regulation of insulin secretion ISS--

    MYRIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MYRIP

    1 HMDB Compound for MYRIP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about MYRIP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYRIP gene (5 alternative transcripts): 
    NM_001284423.1  NM_001284424.1  NM_001284425.1  NM_001284426.1  NM_015460.3  

    Unigene Cluster for MYRIP:

    Myosin VIIA and Rab interacting protein
    Hs.594535  [show with all ESTs]
    Unigene Representative Sequence: BC092512
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444716 ENST00000302541(uc003cka.3 uc010hhu.3 uc010hhv.3 uc010hhw.3 uc011ayz.2)
    ENST00000425621 ENST00000458441 ENST00000458292 ENST00000475082(uc010hhx.1)
    ENST00000459828 ENST00000482033 ENST00000396217 ENST00000539167
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYRIP
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate MYRIP (see all 62):
    hsa-miR-194* hsa-miR-579 hsa-let-7d hsa-miR-15a hsa-miR-200a hsa-miR-650 hsa-miR-449a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidMYRIP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MYRIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYRIP
    Clone
    Products:
         
    OriGene clones in human, mouse for MYRIP (see all 7)
    OriGene ORF clones in mouse, rat for MYRIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYRIP (NM_015460)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYRIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYRIP
    Sirion Biotech Customized lentivirus for stable overexpression of MYRIP 
                         Customized lentivirus expression plasmids for stable overexpression of MYRIP 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MYRIP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYRIP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYRIP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYRIP

    Additional mRNA sequence: 

    AB083783.1 AF396687.1 AK125334.1 AK126013.1 AK294714.1 AK310972.1 AK312412.1 AK316068.1 
    AL050090.1 BC092512.1 BC109311.1 BC109312.1 

    6 DOTS entries:

    DT.411498  DT.99954773  DT.120871429  DT.439321  DT.40246508  DT.75104804 

    24/51 AceView cDNA sequences (see all 51):

    AW594282 AW665105 AA195295 AA455367 AA579870 AW237186 F01507 AA258345 
    AA974678 AB083783 F07858 AL050090 AA323164 AI827924 BF478223 Z45990 
    AA318334 AI968571 BX094817 AA317752 AK126013 AI434843 AF396687 Z41601 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MYRIP    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
    SP1:              -                                                                                                         
    SP2:              -                                                     -                                                   
    SP3:                                                                                                                        
    SP4:              -     -                                                                                                   
    SP5:              -                                                     -     -                                             


    ECgene alternative splicing isoforms for MYRIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYRIP expression in normal human tissues (normalized intensities)      MYRIP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATATGCAC
    MYRIP Expression
    About this image


    MYRIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 5 entries
             Adult Endothelial Cells Blood Brain Barrier
             Human umbilical vein endothelial cells (HUVEC)
             Human Umbilical Vein Endothelial Cells (HUVEC) (ScienceCell)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Human Umbilical Vein Endothelial Cells (HUVEC) (ScienceCell)   
     
     Blood Brain Barrier (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Blood (Hematopoietic System)
             PureStem endothelial Progenitor 30-SM2-3
     
     Brain (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier

    See MYRIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYRIP

    SOURCE GeneReport for Unigene cluster: Hs.594535

    UniProtKB/Swiss-Prot: MYRIP_HUMAN, Q8NFW9
    Tissue specificity: Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle
    and testis

        SABiosciences Custom PCR Arrays for MYRIP
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MYRIP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYRIP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYRIP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYRIP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYRIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MYRIP gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myrip1 , 5 myosin VIIA and Rab interacting protein1, 5 81.77(n)1
    80.33(a)1
      9 (71.50 cM)5
    2450491  NM_144557.51  NP_653140.11 
     1203039365 
    chicken
    (Gallus gallus)
    Aves MYRIP1 myosin VIIA and Rab interacting protein 69.15(n)
    66.86(a)
      428455  XM_426015.3  XP_426015.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    64(a)
    1 → many
    GL343224.1(1658224-1862166)
    zebrafish
    (Danio rerio)
    Actinopterygii myrip1 myosin VIIA and Rab interacting protein 56.07(n)
    50.4(a)
      567049  XM_690337.4  XP_695429.4 


    ENSEMBL Gene Tree for MYRIP (if available)
    TreeFam Gene Tree for MYRIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYRIP gene
    MLPH2  
    3 SIMAP similar genes for MYRIP using alignment to 3 protein entries:     MYRIP_HUMAN (see all proteins):
    MLPH    MOBP    SYTL4

    MYRIP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7104 SNPs in MYRIP are shown (see all 7104)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0617554
    ----see VAR_0617552 A T mis40--------
    VAR_0617564
    ----see VAR_0617562 P L mis40--------
    VAR_0517174
    ----see VAR_0517172 P S mis40--------
    rs170796591,2
    C,F,H--39849329(+) TTGACA/GTTATC 1 -- us2k117Minor allele frequency- G:0.08NA NS EA WA CSA 1228
    rs1819978551,2
    --39849333(+) CATTAC/TCCAAA 1 -- us2k10--------
    rs1850063221,2
    --39849348(+) AAATGC/TACATC 1 -- us2k10--------
    rs98647681,2
    C,F,H--39849382(+) gtacaG/Tattta 1 -- us2k115Minor allele frequency- T:0.14NS EA NA CSA WA 1206
    rs1394841691,2
    --39849403(+) GTACCC/TCCACA 1 -- us2k10--------
    rs1496915501,2
    --39849444(+) CATGCA/GTAATT 1 -- us2k10--------
    rs1445098111,2
    C--39849653(+) TTGTAC/TAACAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MYRIP (39850405 - 40100405 bp, first 250kb of MYRIP)

    Structural Variations
         Database of Genomic Variants (DGV) 10/25 variations for MYRIP (see all 25):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2725187CNV Deletion23290073
    esv2725184CNV Deletion23290073
    esv2725186CNV Deletion23290073
    esv2725181CNV Deletion23290073
    esv2663421CNV Deletion23128226
    esv2656601CNV Deletion23128226
    esv2725182CNV Deletion23290073
    esv4522CNV Deletion18987735
    esv2725183CNV Deletion23290073
    esv1407814CNV Insertion17803354

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MYRIP
    DNA2.0 Custom Variant and Variant Library Synthesis for MYRIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611790    OMIM disorders: --

    4 diseases for MYRIP:    About MalaCards
    age related macular degeneration    macular degeneration    retinitis    endotheliitis


    MYRIP for disorders           About GeneDecksing

    Genetic Association Database (GAD): MYRIP
    Human Genome Epidemiology (HuGE) Navigator: MYRIP (2 documents)

    Export disorders for MYRIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYRIP gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with MYRIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin. (PubMed id 12221080)1, 2, 3, 9 Fukuda M. and Kuroda T.S. (2002)
    2. MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes. (PubMed id 11964381)1, 2, 3 El-Amraoui A.... Petit C. (2002)
    3. Whole genome association scan for genetic polymorphis ms influencing information processing speed. (PubMed id 21130836)1, 4 Luciano M....Deary I.J. (2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. MyRIP anchors protein kinase A to the exocyst complex. (PubMed id 17827149)1, 2 Goehring A.S....Scott J.D. (2007)
    6. Genome-wide association of sleep and circadian phenotypes. (PubMed id 17903308)1, 4 Gottlieb D.J....Wilk J.B. (2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Genome-wide association study identifies germline poly morphisms associated with relapse of childhood acute lymphoblastic leukemia. (PubMed id 23007406)1 Yang J.J....Relling M.V. (2012)
    9. Myrip couples the capture of secretory granules by the actin-rich cell cortex and their attachment to the plasma membrane. (PubMed id 22396429)1 Huet S....Desnos C. (2012)
    10. Myosin Va acts in concert with Rab27a and MyRIP to re gulate acute von-Willebrand factor release from endothelial cells. (PubMed id 21740491)1 Rojo Pulido I....Gerke V. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25924 HGNC: 19156 AceView: MYRIP Ensembl:ENSG00000170011 euGenes: HUgn25924
    ECgene: MYRIP H-InvDB: MYRIP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYRIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYRIP gene:
    Search GeneIP for patents involving MYRIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MYRIP   OriGene RNAi products in human, mouse, rat for MYRIP  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MYRIP  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MYRIP  
     OriGene qSTAR qPCR primer pairs in human, mouse for MYRIP   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MYRIP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MYRIP   OriGene Custom Protein Services for MYRIP  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MYRIP
     QIAGEN SeqTarget long-range PCR primers for resequencing MYRIP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYRIP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYRIP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYRIP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYRIP
     GenScript Custom Purified and Recombinant Proteins Services for MYRIP GenScript cDNA clones with any tag delivered in your preferred vector for MYRIP
     GenScript Custom Assay Services for MYRIP GenScript Custom Superior Antibodies Services for MYRIP
     GenScript Custom overexpressing Cell Line Services for MYRIP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MYRIP promoter
     Search Chromatin IP Primers for MYRIP
     RT2 qPCR Primer Assay in human, mouse, rat MYRIP
     GNC Network for MYRIP
     SABiosciences Custom PCR Arrays for MYRIP
     Search Tocris compounds for MYRIP
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MYRIP antibodies
     MYRIP lysates
     Search for Antibodies for MYRIP at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MYRIP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MYRIP
     Antibodies for MYRIP
     ELISAs for MYRIP
     CLIAs for MYRIP
     Search LifeMap BioReagents cell lines for MYRIP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYRIP
     SwitchGear 3'UTR luciferase reporter plasmids for MYRIP
     SwitchGear Promoter luciferase reporter plasmids for MYRIP
     ThermoFisher Antibodies for MYRIP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYRIP
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MYRIP
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MYRIP
    Customized:
     lentivirus for stable overexpression of MYRIP
     lentivirus expression plasmids for stable overexpression of MYRIP
     adenovirus for overexpression of MYRIP
     LSBio Antibodies in human, mouse, rat for MYRIP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MYRIP gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4