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Aliases for MYRIP Gene

Aliases for MYRIP Gene

  • Myosin VIIA And Rab Interacting Protein 2 3
  • SLAC2C 3 4 6
  • Synaptotagmin-Like Protein Homologue Lacking C2 Domains-C 2 3
  • Synaptotagmin-Like Protein Lacking C2 Domains C 3 4
  • Myosin-VIIa- And Rab-Interacting Protein 3 4
  • Slp Homologue Lacking C2 Domains 2 3
  • Slp Homolog Lacking C2 Domains C 3 4
  • Exophilin-8 3 4
  • SLAC2-C 3 4
  • Rab Effector MYRIP 2
  • Rab Effector MyRIP 3

External Ids for MYRIP Gene

Summaries for MYRIP Gene

GeneCards Summary for MYRIP Gene

MYRIP (Myosin VIIA And Rab Interacting Protein) is a Protein Coding gene. Among its related pathways are Deregulation of Rab and Rab Effector Genes in Bladder Cancer. GO annotations related to this gene include actin binding and myosin binding. An important paralog of this gene is MLPH.

UniProtKB/Swiss-Prot for MYRIP Gene

  • Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYRIP Gene

Genomics for MYRIP Gene

Genomic Location for MYRIP Gene

Start:
39,808,914 bp from pter
End:
40,260,321 bp from pter
Size:
451,408 bases
Orientation:
Plus strand

Genomic View for MYRIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYRIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYRIP Gene

Regulatory Elements for MYRIP Gene

Proteins for MYRIP Gene

  • Protein details for MYRIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFW9-MYRIP_HUMAN
    Recommended name:
    Rab effector MyRIP
    Protein Accession:
    Q8NFW9
    Secondary Accessions:
    • B3KWM3
    • B3KWW4
    • B7Z2H1
    • B7Z9V3
    • G3XAI8
    • Q32M41
    • Q32M42
    • Q569F7
    • Q8IUF5
    • Q9Y3V4

    Protein attributes for MYRIP Gene

    Size:
    859 amino acids
    Molecular mass:
    95706 Da
    Quaternary structure:
    • Binds MYO5A, MYO7A and F-actin (By similarity). Binds RAB27A that has been activated by GTP-binding via its N-terminus. Interacts with PRKAR2A. Interacts with components of the exocyst complex, including EXOC3 and EXOC4 (By similarity).

    Alternative splice isoforms for MYRIP Gene

neXtProt entry for MYRIP Gene

Proteomics data for MYRIP Gene at MOPED

Post-translational modifications for MYRIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYRIP Gene

Domains for MYRIP Gene

Gene Families for MYRIP Gene

HGNC:
  • AKAP :A-kinase anchor proteins

Protein Domains for MYRIP Gene

UniProtKB/Swiss-Prot:

MYRIP_HUMAN
Domain:
  • Contains 1 RabBD (Rab-binding) domain.:
    • Q8NFW9
Similarity:
  • Contains 1 FYVE-type zinc finger.:
    • Q8NFW9
genes like me logo Genes that share domains with MYRIP: view

Function for MYRIP Gene

Molecular function for MYRIP Gene

UniProtKB/Swiss-Prot Function: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity).

Gene Ontology (GO) - Molecular Function for MYRIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 11964381
GO:0008270 zinc ion binding NAS 11964381
GO:0017137 Rab GTPase binding IEA --
GO:0051018 protein kinase A binding IEA --
genes like me logo Genes that share ontologies with MYRIP: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MYRIP Gene

Localization for MYRIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYRIP Gene

Cytoplasm. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle. Note=In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYRIP Gene COMPARTMENTS Subcellular localization image for MYRIP gene
Compartment Confidence
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for MYRIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IEA --
GO:0001750 photoreceptor outer segment IEA --
GO:0015629 actin cytoskeleton IEA --
GO:0030133 transport vesicle IEA --
GO:0031045 dense core granule ISS --
genes like me logo Genes that share ontologies with MYRIP: view

Pathways for MYRIP Gene

genes like me logo Genes that share pathways with MYRIP: view

Pathways by source for MYRIP Gene

Gene Ontology (GO) - Biological Process for MYRIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0032024 positive regulation of insulin secretion ISS --
genes like me logo Genes that share ontologies with MYRIP: view

Compounds for MYRIP Gene

(1) HMDB Compounds for MYRIP Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with MYRIP: view

Transcripts for MYRIP Gene

Unigene Clusters for MYRIP Gene

Myosin VIIA and Rab interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYRIP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: -
SP2: - -
SP3:
SP4: - -
SP5: - - -

Relevant External Links for MYRIP Gene

GeneLoc Exon Structure for
MYRIP
ECgene alternative splicing isoforms for
MYRIP

Expression for MYRIP Gene

mRNA expression in normal human tissues for MYRIP Gene

mRNA differential expression in normal tissues according to GTEx for MYRIP Gene

This gene is overexpressed in Brain - Amygdala (7.1) and Brain - Anterior cingulate cortex (BA24) (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYRIP Gene

SOURCE GeneReport for Unigene cluster for MYRIP Gene Hs.594535

mRNA Expression by UniProt/SwissProt for MYRIP Gene

Q8NFW9-MYRIP_HUMAN
Tissue specificity: Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle and testis
genes like me logo Genes that share expressions with MYRIP: view

Orthologs for MYRIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYRIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYRIP 36
  • 99.34 (n)
  • 99.53 (a)
MYRIP 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYRIP 36
  • 85.97 (n)
  • 84.06 (a)
MYRIP 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYRIP 36
  • 86.89 (n)
  • 87.05 (a)
MYRIP 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myrip 36
  • 81.77 (n)
  • 80.33 (a)
Myrip 16
Myrip 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYRIP 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYRIP 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myrip 36
  • 80.99 (n)
  • 79.16 (a)
chicken
(Gallus gallus)
Aves MYRIP 36
  • 69.15 (n)
  • 66.86 (a)
MYRIP 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYRIP 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myrip 36
  • 64.27 (n)
  • 63.4 (a)
zebrafish
(Danio rerio)
Actinopterygii myrip 36
  • 59.57 (n)
  • 56.4 (a)
myrip 37
  • 34 (a)
OneToMany
MYRIP (2 of 2) 37
  • 29 (a)
OneToMany
Species with no ortholog for MYRIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYRIP Gene

ENSEMBL:
Gene Tree for MYRIP (if available)
TreeFam:
Gene Tree for MYRIP (if available)

Paralogs for MYRIP Gene

Paralogs for MYRIP Gene

Selected SIMAP similar genes for MYRIP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MYRIP: view

Variants for MYRIP Gene

Sequence variations from dbSNP and Humsavar for MYRIP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs462263 -- 39,840,161(+) tgttt(G/T)gggtg intron-variant
rs716393 -- 39,904,293(+) ccagg(C/T)tggag intron-variant
rs716462 -- 39,945,757(-) CAAAT(C/T)TTAAA intron-variant
rs716463 -- 39,945,708(-) TTTAA(C/T)CTGCG intron-variant
rs725294 -- 39,946,498(-) ACCTT(C/T)CGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYRIP Gene

Variant ID Type Subtype PubMed ID
dgv5125n71 CNV Loss 21882294
nsv517803 CNV Gain 19592680
nsv523927 CNV Loss 19592680
nsv3773 CNV Insertion 18451855
nsv520165 CNV Gain 19592680
nsv460510 CNV Loss 19166990
esv2656601 CNV Deletion 23128226
nsv470538 CNV Loss 18288195
esv1686953 CNV Insertion 17803354
esv2725181 CNV Deletion 23290073
esv1407814 CNV Insertion 17803354
esv2725182 CNV Deletion 23290073
esv4522 CNV Deletion 18987735
esv2663421 CNV Deletion 23128226
esv2725183 CNV Deletion 23290073
esv2725184 CNV Deletion 23290073
nsv834667 CNV Gain 17160897
nsv876715 CNV Gain 21882294
nsv509823 CNV Loss 20534489
esv269922 CNV Insertion 20981092
nsv512798 CNV Insertion 21212237
esv1251654 CNV Insertion 17803354
esv1700873 CNV Insertion 17803354
esv2725186 CNV Deletion 23290073
esv2725187 CNV Deletion 23290073

Relevant External Links for MYRIP Gene

HapMap Linkage Disequilibrium report
MYRIP

Disorders for MYRIP Gene

Relevant External Links for MYRIP

Genetic Association Database (GAD)
MYRIP
Human Genome Epidemiology (HuGE) Navigator
MYRIP
genes like me logo Genes that share disorders with MYRIP: view

No data available for UniProtKB/Swiss-Prot for MYRIP Gene

Publications for MYRIP Gene

  1. Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin. (PMID: 12221080) Fukuda M. … Kuroda T.S. (J. Biol. Chem. 2002) 2 3 4 23
  2. MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes. (PMID: 11964381) El-Amraoui A. … Petit C. (EMBO Rep. 2002) 2 3 4
  3. MyRIP anchors protein kinase A to the exocyst complex. (PMID: 17827149) Goehring A.S. … Scott J.D. (J. Biol. Chem. 2007) 3 4
  4. Genome-wide association of sleep and circadian phenotypes. (PMID: 17903308) Gottlieb D.J. … Wilk J.B. (BMC Med. Genet. 2007) 3 49
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MYRIP Gene

Sources for MYRIP Gene

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