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Aliases for MYRFL Gene

Aliases for MYRFL Gene

  • Myelin Regulatory Factor-Like 2 3 5
  • C12orf15 3 4
  • C12orf28 3 4
  • Myelin Regulatory Factor-Like Protein 3
  • Chromosome 12 Open Reading Frame 15 2
  • Chromosome 12 Open Reading Frame 28 2
  • Bcm1377 3

External Ids for MYRFL Gene

Previous HGNC Symbols for MYRFL Gene

  • C12orf15
  • C12orf28

Previous GeneCards Identifiers for MYRFL Gene

  • GC12P070221

Summaries for MYRFL Gene

GeneCards Summary for MYRFL Gene

MYRFL (Myelin Regulatory Factor-Like) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is MYRF.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYRFL Gene

Genomics for MYRFL Gene

Regulatory Elements for MYRFL Gene

Enhancers for MYRFL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G069738 1.1 ENCODE 22.5 -85.1 -85108 2.5 HNRNPUL1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 KLF13 SP3 SP5 ENSG00000257815 MYRFL LOC101928002 RAB3IP ENSG00000258052
GH12G069833 0.6 ENCODE 27 +11.6 11602 5.7 SOX5 SOX13 CTCF HLF CEBPB ZNF644 GATA2 CEBPA PRDM1 MYRFL RAB3IP ENSG00000257241
GH12G069986 1.4 FANTOM5 Ensembl ENCODE 8.3 +163.8 163804 2.7 TBP PKNOX1 ZSCAN4 ZNF76 GATA2 ZNF143 RCOR1 FOS CEBPB ZEB2 CCT2 MYRFL ENSG00000257815 RAB3IP ENSG00000257241 LOC100125409
GH12G069935 0.9 FANTOM5 ENCODE 12.1 +111.7 111727 1.5 CTCF ESRRA TEAD4 RBBP5 REST DPF2 ZNF217 CTBP1 JUND POLR2A MYRFL ENSG00000257241
GH12G069994 0.9 FANTOM5 ENCODE 7.1 +170.1 170142 1.3 PKNOX1 ESRRA BHLHE40 ZNF394 PRDM6 NFIC PBX2 HNF4G HNF4A CCT2 MYRFL ENSG00000257815 RAB3IP ENSG00000257241 LOC100125409
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYRFL on UCSC Golden Path with GeneCards custom track

Genomic Location for MYRFL Gene

Chromosome:
12
Start:
69,824,569 bp from pter
End:
69,959,097 bp from pter
Size:
134,529 bases
Orientation:
Plus strand

Genomic View for MYRFL Gene

Genes around MYRFL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYRFL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYRFL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYRFL Gene

Proteins for MYRFL Gene

  • Protein details for MYRFL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LU7-MRFL_HUMAN
    Recommended name:
    Myelin regulatory factor-like protein
    Protein Accession:
    Q96LU7

    Protein attributes for MYRFL Gene

    Size:
    910 amino acids
    Molecular mass:
    101670 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71571.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MYRFL Gene

Post-translational modifications for MYRFL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYRFL Gene

Domains & Families for MYRFL Gene

Suggested Antigen Peptide Sequences for MYRFL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LU7

UniProtKB/Swiss-Prot:

MRFL_HUMAN :
  • Belongs to the MRF family.
Family:
  • Belongs to the MRF family.
genes like me logo Genes that share domains with MYRFL: view

No data available for Gene Families for MYRFL Gene

Function for MYRFL Gene

Gene Ontology (GO) - Molecular Function for MYRFL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with MYRFL: view

Phenotypes for MYRFL Gene

genes like me logo Genes that share phenotypes with MYRFL: view

Animal Models for MYRFL Gene

MGI Knock Outs for MYRFL:

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MYRFL Gene

Localization for MYRFL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYRFL Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYRFL gene
Compartment Confidence
extracellular 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MYRFL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MYRFL: view

Pathways & Interactions for MYRFL Gene

SuperPathways for MYRFL Gene

No Data Available

Interacting Proteins for MYRFL Gene

Gene Ontology (GO) - Biological Process for MYRFL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MYRFL: view

No data available for Pathways by source and SIGNOR curated interactions for MYRFL Gene

Drugs & Compounds for MYRFL Gene

No Compound Related Data Available

Transcripts for MYRFL Gene

mRNA/cDNA for MYRFL Gene

(13) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYRFL Gene

Myelin regulatory factor-like:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYRFL Gene

No ASD Table

Relevant External Links for MYRFL Gene

GeneLoc Exon Structure for
MYRFL
ECgene alternative splicing isoforms for
MYRFL

Expression for MYRFL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYRFL Gene

mRNA differential expression in normal tissues according to GTEx for MYRFL Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x18.8) and Testis (x4.2).

Protein differential expression in normal tissues from HIPED for MYRFL Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYRFL Gene



Protein tissue co-expression partners for MYRFL Gene

NURSA nuclear receptor signaling pathways regulating expression of MYRFL Gene:

MYRFL

SOURCE GeneReport for Unigene cluster for MYRFL Gene:

Hs.253773

Evidence on tissue expression from TISSUES for MYRFL Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MYRFL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYRFL Gene

Orthologs for MYRFL Gene

This gene was present in the common ancestor of animals.

Orthologs for MYRFL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYRFL 34 35
  • 99.41 (n)
cow
(Bos Taurus)
Mammalia MYRFL 34 35
  • 88.44 (n)
dog
(Canis familiaris)
Mammalia MYRFL 34 35
  • 87.39 (n)
mouse
(Mus musculus)
Mammalia Myrfl 34 16 35
  • 84.05 (n)
rat
(Rattus norvegicus)
Mammalia Myrfl 34
  • 80.61 (n)
oppossum
(Monodelphis domestica)
Mammalia MYRFL 35
  • 19 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYRFL 35
  • 12 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYRFL 34 35
  • 70.63 (n)
lizard
(Anolis carolinensis)
Reptilia MYRFL 35
  • 13 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myrfl 34
  • 66.28 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100329855 34
  • 57.91 (n)
MYRFL 35
  • 8 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3328 35
  • 2 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pqn-47 34 35
  • 45.11 (n)
F21A10.2 35
  • 4 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 1 (a)
OneToMany
Species where no ortholog for MYRFL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYRFL Gene

ENSEMBL:
Gene Tree for MYRFL (if available)
TreeFam:
Gene Tree for MYRFL (if available)

Paralogs for MYRFL Gene

Paralogs for MYRFL Gene

(2) SIMAP similar genes for MYRFL Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MYRFL: view

Variants for MYRFL Gene

Sequence variations from dbSNP and Humsavar for MYRFL Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000106434 -- 69,945,677(+) GACAA(C/T)ACAGA intron-variant
rs1000125489 -- 69,854,151(+) ACCAG(C/T)CCGGC intron-variant, upstream-variant-2KB
rs1000130571 -- 69,955,654(+) TAACC(C/T)CTATA intron-variant
rs1000178131 -- 69,905,218(+) TGTAA(A/G)TTGAA intron-variant
rs1000185599 -- 69,915,452(+) TTGCT(A/G)TGTCA intron-variant

Variation tolerance for MYRFL Gene

Gene Damage Index Score: 11.06; 92.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYRFL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYRFL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MYRFL Gene

Disorders for MYRFL Gene

Relevant External Links for MYRFL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYRFL

No disorders were found for MYRFL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYRFL Gene

Publications for MYRFL Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney R.J. … Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 64
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for MYRFL Gene

Sources for MYRFL Gene

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