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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYRFL Gene

protein-coding   GIFtS: 33
GCID: GC12P070221

Myelin Regulatory Factor-Like

(Previous names: chromosome 12 open reading frame 15, chromosome 12 open...)
(Previous symbols: C12orf15, C12orf28)
  Search for MYRFL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Myelin Regulatory Factor-Like1 2     Chromosome 12 Open Reading Frame 281
C12orf151 2 3     bcm13772
C12orf281 2 3     Myelin Regulatory Factor-Like Protein2
Chromosome 12 Open Reading Frame 151     

External Ids:    HGNC: 263161   Entrez Gene: 1964462   Ensembl: ENSG000001662687   UniProtKB: Q96LU73   

Export aliases for MYRFL gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MYRFL Gene: 
MYRFL (myelin regulatory factor-like) is a protein-coding gene. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MYRF.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MYRFL
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MYRFL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYRFL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q15

MYRFL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYRFL gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P070221:  view genomic region     (about GC identifiers)

Start:
70,219,084 bp from pter      End:
70,352,877 bp from pter
Size:
133,794 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MRFL_HUMAN, Q96LU7 (See protein sequence)
Recommended Name: Myelin regulatory factor-like protein  
Size: 910 amino acids; 101670 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=BAB71571.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Explore the universe of human proteins at neXtProt for MYRFL: NX_Q96LU7

Explore proteomics data for MYRFL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96LU7

  • MYRFL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYRFL Protein Expression

    ENSEMBL proteins: 
     ENSP00000448753   ENSP00000449598   ENSP00000447167   ENSP00000440626   ENSP00000299350  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    MYRFL for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR008967 p53-like_TF_DNA-bd
     IPR025719 MRF_C2
     IPR024061 NDT80_DNA-bd_dom
     IPR026932 MRF_C1

    Graphical View of Domain Structure for InterPro Entry Q96LU7

    ProtoNet protein and cluster: Q96LU7

    UniProtKB/Swiss-Prot: MRFL_HUMAN, Q96LU7
    Similarity: Belongs to the MRF family
    Similarity: Contains 1 NDT80 DNA-binding domain


    MYRFL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
         
    MYRFL for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYRFL

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----

    MYRFL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MYRFL (MRFL)

    Search CenterWatch for drugs/clinical trials and news about MYRFL / MRFL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYRFL gene: 
    NM_182530.1  

    Unigene Cluster for MYRFL:

    Myelin regulatory factor-like
    Hs.253773  [show with all ESTs]
    Unigene Representative Sequence: AK057785
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552032 ENST00000547771 ENST00000548892 ENST00000535034 ENST00000299350(uc001svu.1 uc010stn.1)

    miRNA
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                         Customized lentivirus expression plasmids for stable overexpression of MYRFL 
    Primer
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    Additional mRNA sequence: 

    AK057785.1 BC101820.1 BC143553.1 

    1 DOTS entry:

    DT.75139805 

    7 AceView cDNA sequences:

    AW236718 NM_182530 AK057785 T93744 BG187742 BG207834 BG213579 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYRFL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MYRFL Expression
    About this image


    See MYRFL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYRFL

    SOURCE GeneReport for Unigene cluster: Hs.253773
        SABiosciences Custom PCR Arrays for MYRFL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYRFL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MYRFL gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myrfl5
    Gm2391
    predicted gene 2391, 5 84.23(n)1
    85.07(a)1
      10 (64.90 cM)5
    2375581  NM_001033333.31  NP_001028505.11 
     1167765455 
    chicken
    (Gallus gallus)
    Aves C12ORF286
    Uncharacterized protein
    10(a)
    1 ↔ 1
    1(35554524-35597127)
    lizard
    (Anolis carolinensis)
    Reptilia MYRFL6
    myelin regulatory factor-like
    11(a)
    1 ↔ 1
    GL343256.1(1755653-1819588)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003298551 myelin gene regulatory factor-like 62.64(n)
    62.92(a)
      100329855  XM_002667649.2  XP_002667695.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG33286
    --
    2(a)
    1 → many
    2R(20050013-20061150)
    worm
    (Caenorhabditis elegans)
    Secernentea F21A10.21 Protein F21A10.2 45.57(n)
    34.82(a)
      181229  NM_077308.3  NP_509709.2 


    ENSEMBL Gene Tree for MYRFL (if available)
    TreeFam Gene Tree for MYRFL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYRFL gene
    MYRF2  
    2 SIMAP similar genes for MYRFL using alignment to 5 protein entries:     MRFL_HUMAN (see all proteins):
    C12orf28    MYRF

    MYRFL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1726 SNPs in MYRFL are shown (see all 1726)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105664151,2
    C--67324876(+) TCCTG-/GTT   
       TT
    /TT
    TTTTT
    1 -- int10--------
    rs353861901,2
    C--67351874(+) TCACAG/-TGATA 1 -- int11Minor allele frequency- -:0.50NA 2
    rs802149881,2
    C--67370064(+) CAACA-/CA    
       T
    /TCA
    TTCAG
    2 -- int1 cds10--------
    rs2006158171,2
    --67370065(+) AACAT-/CATTCAG 1 -- int10--------
    rs746639751,2
    C--67375631(+) CAAATC/TCCCCG 1 -- int10--------
    rs17326871,2
    A--67377856(+) AGGTCG/TTCTTA 1 -- int10--------
    rs108790651,2,4
    C,F,A,H--67401882(+) AAGGGA/CTGGAA 2 M L mis1 ese327Minor allele frequency- N:0.00EA NA NS CSA WA EU 3559
    rs1380331401,2
    --70108478(+) TCTTT-/CTTTTT 1 -- us2k10--------
    rs681489641,2
    C--70108480(+) TTCTT-/TC/TTC
    /TTCTTTC
    TTTTT
    2 -- us2k1 cds10--------
    rs556944651,2
    C--70108481(+) TCTTT-/CTTTCTT/CTTT
    CTTTCTT
    /CTTTTC
    TTTTT
    2 -- us2k1 cds11NA 2

    HapMap Linkage Disequilibrium report for MYRFL (70219084 - 70352877 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MYRFL: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MYRFL
    DNA2.0 Custom Variant and Variant Library Synthesis for MYRFL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYRFL gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MYRFL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PubMed id 18951430)1 Anney R.J....Gill M. (2008)
    4. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 196446 HGNC: 26316 AceView: FLJ25056 Ensembl:ENSG00000166268 euGenes: HUgn196446
    ECgene: MYRFL H-InvDB: MYRFL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYRFL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYRFL gene:
    Search GeneIP for patents involving MYRFL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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