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Aliases for MYRF Gene

Aliases for MYRF Gene

  • Myelin Regulatory Factor 2 3
  • Myelin Gene Regulatory Factor 2 3 4
  • C11orf9 3 4 6
  • KIAA0954 4 6
  • MRF 3 4
  • Chromosome 11 Open Reading Frame 9 2
  • EC 3.4.-.- 4
  • Pqn-47 3
  • Ndt80 3

External Ids for MYRF Gene

Previous Symbols for MYRF Gene

  • C11orf9

Summaries for MYRF Gene

Entrez Gene Summary for MYRF Gene

  • This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

GeneCards Summary for MYRF Gene

MYRF (Myelin Regulatory Factor) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MYRFL.

UniProtKB/Swiss-Prot for MYRF Gene

  • Myelin regulatory factor: Consitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832).

  • Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage.

  • Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5-CTGGYAC-3 in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYRF Gene

Genomics for MYRF Gene

Genomic Location for MYRF Gene

Start:
61,752,642 bp from pter
End:
61,788,518 bp from pter
Size:
35,877 bases
Orientation:
Plus strand

Genomic View for MYRF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYRF Gene

No data available for Regulatory Elements for MYRF Gene

Proteins for MYRF Gene

  • Protein details for MYRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2G1-MRF_HUMAN
    Recommended name:
    Myelin regulatory factor
    Protein Accession:
    Q9Y2G1
    Secondary Accessions:
    • O43582
    • Q9P1Q6

    Protein attributes for MYRF Gene

    Size:
    1151 amino acids
    Molecular mass:
    124397 Da
    Quaternary structure:
    • Homotrimer.
    SequenceCaution:
    • Sequence=BAA76798.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MYRF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYRF Gene

Proteomics data for MYRF Gene at MOPED

Post-translational modifications for MYRF Gene

  • Myelin regulatory factor, C-terminal: Glycosylated.
  • Myelin regulatory factor: Follows autocatalytic cleavage via the peptidase S74 domain. Autoprocessing is apparently constitutive and is essential for transcriptional activity.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn919, Thr932, Ser938, Ser942, Ser954, Ser960, Asn1043, Asn1065, and Asn1129

Other Protein References for MYRF Gene

No data available for DME Specific Peptides for MYRF Gene

Domains for MYRF Gene

Protein Domains for MYRF Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2G1

UniProtKB/Swiss-Prot:

MRF_HUMAN
Domain:
  • Myelin regulatory factor, N-terminal: The nuclear localization signals mediate translocation to the nucleus.:
    • Q9Y2G1
  • Myelin regulatory factor: The peptidase S74 domain, also named Intramolecular Chaperone Auto-processed (ICA) domain or Intramolecuar Chaperone Domain (ICD), has protease activity and mediates autocatalytic processing of the protein to generate the Myelin regulatory factor, N-terminal active transcription factor and the Myelin regulatory factor, C-terminal components.:
    • Q9Y2G1
  • Contains 1 NDT80 DNA-binding domain.:
    • Q9Y2G1
  • Contains 1 peptidase S74 domain.:
    • Q9Y2G1
Family:
  • Belongs to the MRF family.:
    • Q9Y2G1
genes like me logo Genes that share domains with MYRF: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MYRF Gene

Function for MYRF Gene

Molecular function for MYRF Gene

UniProtKB/Swiss-Prot Function: Myelin regulatory factor: Consitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832).
UniProtKB/Swiss-Prot Function: Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage.
UniProtKB/Swiss-Prot Function: Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5-CTGGYAC-3 in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832).

Enzyme Numbers (IUBMB) for MYRF Gene

Gene Ontology (GO) - Molecular Function for MYRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with MYRF: view
genes like me logo Genes that share phenotypes with MYRF: view

miRNA for MYRF Gene

miRTarBase miRNAs that target MYRF

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MYRF Gene

Localization for MYRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYRF Gene

Myelin regulatory factor: Endoplasmic reticulum membrane; Single-pass membrane protein.
Myelin regulatory factor, N-terminal: Nucleus. Cytoplasm. Note=Translocates from the cytoplasm to the nucleus upon autocatalytic cleavage.
Myelin regulatory factor, C-terminal: Endoplasmic reticulum membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MYRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MYRF: view

No data available for Subcellular locations from COMPARTMENTS for MYRF Gene

Pathways for MYRF Gene

SuperPathways for MYRF Gene

No Data Available

Interacting Proteins for MYRF Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000278836%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000278836 for MYRF Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for MYRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006508 proteolysis IEA --
GO:0014003 oligodendrocyte development ISS --
GO:0022010 central nervous system myelination ISS --
genes like me logo Genes that share ontologies with MYRF: view

No data available for Pathways by source for MYRF Gene

Transcripts for MYRF Gene

Unigene Clusters for MYRF Gene

Myelin regulatory factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYRF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - - - - - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b · 24c · 24d ^ 25a · 25b · 25c · 25d · 25e ^ 26a · 26b · 26c ^ 27 ^ 28 ^ 29a · 29b ^ 30
SP1: -
SP2: -
SP3: -
SP4: - -
SP5: -
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11: -
SP12: - - - - - - - - - -
SP13:
SP14:
SP15:
SP16:
SP17: - -
SP18:
SP19:

Relevant External Links for MYRF Gene

GeneLoc Exon Structure for
MYRF
ECgene alternative splicing isoforms for
MYRF

Expression for MYRF Gene

mRNA expression in normal human tissues for MYRF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYRF Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (8.6), Brain - Substantia nigra (5.5), Stomach (4.2), and Brain - Hippocampus (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYRF Gene

SOURCE GeneReport for Unigene cluster for MYRF Gene Hs.473109

mRNA Expression by UniProt/SwissProt for MYRF Gene

Q9Y2G1-MRF_HUMAN
Tissue specificity: Expressed in lung, ARPE-19 cell line, brainstem, uterus and, to a lesser extent, in basal ganglion and liver. Weakly expressed in cerebellum and retina.
genes like me logo Genes that share expressions with MYRF: view

Orthologs for MYRF Gene

This gene was present in the common ancestor of animals.

Orthologs for MYRF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf9 35
  • 96.69 (n)
  • 96.54 (a)
MYRF 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYRF 35
  • 89.67 (n)
  • 91.29 (a)
MYRF 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C18H11orf9 35
  • 89.83 (n)
  • 92.07 (a)
MYRF 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myrf 35
  • 86.58 (n)
  • 90.09 (a)
Myrf 16
Myrf 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYRF 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myrf 35
  • 86.88 (n)
  • 89.57 (a)
chicken
(Gallus gallus)
Aves C5H11ORF9 35
  • 73.76 (n)
  • 73.51 (a)
MYRF 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYRF 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myrf 35
  • 65.14 (n)
  • 65.43 (a)
zebrafish
(Danio rerio)
Actinopterygii myrf 35
  • 62.41 (n)
  • 59.86 (a)
myrf 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3328 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F21A10.2 36
  • 23 (a)
ManyToMany
pqn-47 36
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToMany
Species with no ortholog for MYRF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYRF Gene

ENSEMBL:
Gene Tree for MYRF (if available)
TreeFam:
Gene Tree for MYRF (if available)

Paralogs for MYRF Gene

Paralogs for MYRF Gene

Selected SIMAP similar genes for MYRF Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MYRF: view

Variants for MYRF Gene

Sequence variations from dbSNP and Humsavar for MYRF Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs108499 -- 61,779,765(+) TCCTC(C/T)GACCT intron-variant
rs149803 -- 61,771,548(+) CCCCC(C/G)AGCAC reference, synonymous-codon
rs149804 -- 61,771,134(+) TCCAT(A/G)GAGCC intron-variant
rs174527 -- 61,770,929(+) CCCCC(C/G)ACTCT intron-variant
rs174528 -- 61,776,027(+) CATCC(C/T)GAGGT intron-variant

Relevant External Links for MYRF Gene

HapMap Linkage Disequilibrium report
MYRF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MYRF Gene

Disorders for MYRF Gene

No disorders were found for MYRF Gene.

No data available for UniProtKB/Swiss-Prot for MYRF Gene

Publications for MYRF Gene

  1. cDNA cloning and genomic structure of a novel gene (C11orf9) localized to chromosome 11q12-->q13.1 which encodes a highly conserved, potential membrane-associated protein. (PMID: 10828591) Stoehr H. … Weber B.H.F. (Cytogenet. Cell Genet. 2000) 2 3 4
  2. Crystal structure of the DNA-binding domain from Ndt80, a transcriptional activator required for meiosis in yeast. (PMID: 12384578) Montano S.P. … Georgiadis M.M. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF. (PMID: 23966832) Li Z. … Marcotte E.M. (PLoS Biol. 2013) 3 4
  4. Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes. (PMID: 9615227) Cooper P.R. … Shows T.B. (Genomics 1998) 3 4
  5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4

Products for MYRF Gene

Sources for MYRF Gene

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