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MYRF Gene

protein-coding   GIFtS: 41
GCID: GC11P061521

Myelin Regulatory Factor

(Previous name: chromosome 11 open reading frame 9)
(Previous symbol: C11orf9)
  Search for MYRF
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myelin Regulatory Factor1 2     Chromosome 11 Open Reading Frame 91
C11orf91 2 3 5     Ndt802
Myelin Gene Regulatory Factor1 2 3     pqn-472
MRF2 3     EC 3.4.-.-3
KIAA09543 5     

External Ids:    HGNC: 11811   Entrez Gene: 7452   Ensembl: ENSG000001249207   OMIM: 6083295   UniProtKB: Q9Y2G13   

Export aliases for MYRF gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYRF Gene:
MYRF (myelin regulatory factor) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MYRFL.

UniProtKB/Swiss-Prot: MRF_HUMAN, Q9Y2G1
Function: Myelin regulatory factor: Consitutes a precursor of the transcription factor. Mediates the autocatalytic
cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates
transcription of central nervous system (CNS) myelin genes (PubMed:23966832)
Function: Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and
remains attached to the endoplasmic reticulum membrane following cleavage (PubMed:23966832)
Function: Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of
myelin genes such as MBP, MOG, MAG and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central
role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence
5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not
only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance
of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype
(PubMed:23966832)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MYRF
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYRF promoter sequence
   Search Chromatin IP Primers for MYRF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYRF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12-q13.1   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12-q13.1

MYRF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYRF gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P061521:  view genomic region     (about GC identifiers)

Start:
61,520,114 bp from pter      End:
61,555,990 bp from pter
Size:
35,877 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MRF_HUMAN, Q9Y2G1 (See protein sequence)
Recommended Name: Myelin regulatory factor  
Size: 1151 amino acids; 124397 Da
Subunit: Homotrimer
Sequence caution: Sequence=BAA76798.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O43582 Q9P1Q6
Alternative splicing: 2 isoforms:  Q9Y2G1-1   Q9Y2G1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYRF: NX_Q9Y2G1

Explore proteomics data for MYRF at MOPED

Post-translational modifications: 

  • Myelin regulatory factor, C-terminal: Glycosylated1
  • Myelin regulatory factor: Follows autocatalytic cleavage via the peptidase S74 domain. Autoprocessing is
    apparently constitutive and is essential for transcriptional activity (PubMed:23966832)1
  • Glycosylation2 at Asn919, Thr932, Ser938, Ser942, Ser954, Ser960, Asn1043, Asn1065, Asn1129
  • Modification sites at PhosphoSitePlus

  • See MYRF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001120864.1  NP_037411.1  

    ENSEMBL proteins: 
     ENSP00000278836   ENSP00000265460   ENSP00000374253   ENSP00000333261  

    MYRF Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MYRF 

    MYRF Antibody Products:

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    Search eBioscience for ELISAs for MYRF 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR008967 p53-like_TF_DNA-bd
     IPR026933 MRF
     IPR025719 MRF_C2
     IPR024061 NDT80_DNA-bd_dom
     IPR026932 MRF_C1

    Graphical View of Domain Structure for InterPro Entry Q9Y2G1

    ProtoNet protein and cluster: Q9Y2G1

    UniProtKB/Swiss-Prot: MRF_HUMAN, Q9Y2G1
    Domain: Myelin regulatory factor, N-terminal: The nuclear localization signals mediate translocation to the
    nucleus (PubMed:23966832)
    Domain: Myelin regulatory factor: The peptidase S74 domain, also named Intramolecular Chaperone Auto-processed
    (ICA) domain or Intramolecuar Chaperone Domain (ICD), has protease activity and mediates autocatalytic processing
    of the protein to generate the Myelin regulatory factor, N-terminal active transcription factor and the Myelin
    regulatory factor, C-terminal components (PubMed:23966832)
    Similarity: Belongs to the MRF family
    Similarity: Contains 1 NDT80 DNA-binding domain
    Similarity: Contains 1 peptidase S74 domain


    Find genes that share domains with MYRF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRF_HUMAN, Q9Y2G1
    Function: Myelin regulatory factor: Consitutes a precursor of the transcription factor. Mediates the autocatalytic
    cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates
    transcription of central nervous system (CNS) myelin genes (PubMed:23966832)
    Function: Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and
    remains attached to the endoplasmic reticulum membrane following cleavage (PubMed:23966832)
    Function: Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of
    myelin genes such as MBP, MOG, MAG and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central
    role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence
    5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not
    only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance
    of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype
    (PubMed:23966832)

         Enzyme Number (IUBMB): EC 3.4.-.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008233peptidase activity IEA--
         
    Find genes that share ontologies with MYRF           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MYRF:
     Increased S DNA content  Increased number of mitotic ce 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Myrf):
     behavior/neurological  mortality/aging  nervous system  vision/eye 

    Find genes that share phenotypes with MYRF           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYRF
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYRF

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    hsa-mir-145-5p (MIRT005688), hsa-mir-330-5p (MIRT038236)

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    SwitchGear 3'UTR luciferase reporter plasmidMYRF 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MRF_HUMAN, Q9Y2G1: Myelin regulatory factor: Endoplasmic reticulum membrane; Single-pass membrane protein
    MRF_HUMAN, Q9Y2G1: Myelin regulatory factor, N-terminal: Nucleus. Cytoplasm. Note=Translocates from the
    cytoplasm to the nucleus upon autocatalytic cleavage
    MRF_HUMAN, Q9Y2G1: Myelin regulatory factor, C-terminal: Endoplasmic reticulum membrane; Single-pass membrane
    protein

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with MYRF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYRF
    Interactions:

        Search GeneGlobe Interaction Network for MYRF

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for MYRF (ENSP000002788364) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006508proteolysis ----
    GO:0014003oligodendrocyte development ISS--
    GO:0022010central nervous system myelination ISS--

    Find genes that share ontologies with MYRF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYRF (MRF)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYRF gene (2 alternative transcripts): 
    NM_001127392.1  NM_013279.2  

    Unigene Cluster for MYRF:

    Myelin regulatory factor
    Hs.473109  [show with all ESTs]
    Unigene Representative Sequence: AB023171
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537766 ENST00000278836(uc001nsc.1 uc010rll.1) ENST00000265460(uc001nse.1)
    ENST00000389602 ENST00000536352 ENST00000537318 ENST00000546247 ENST00000539361
    ENST00000327797
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidMYRF 3' UTR sequence
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYRF
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat MYRF
      QuantiFast Probe-based Assays in human, mouse, rat MYRF

    Additional mRNA sequence: 

    AB023171.2 AF038536.1 AF086762.1 AK295013.1 AK311259.1 BC004938.1 BC020196.1 

    10 DOTS entries:

    DT.455243  DT.100746926  DT.120740139  DT.120740111  DT.95193900  DT.120739971  DT.97779979  DT.102834421 
    DT.40109453  DT.95193919 

    Selected AceView cDNA sequences (see all 187):

    BI038309 AA777626 BM783794 AF086762 F02898 BM765269 BM993407 N46745 
    AB023171 BQ882629 BE049430 AI866750 BM783535 Z39682 NM_013279 BE378314 
    BC020196 BQ898720 BM783055 AW662897 BU622970 BM784387 AI366703 BM855502 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYRF (see all 19)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b · 24c · 24d ^ 25a · 25b · 25c · 25d · 25e ^ 26a · 26b · 26c ^ 27 ^ 28 ^ 29a · 29b ^ 30
    SP1:  -                                                                                                                                                   
    SP2:  -                                                                                                                                                   
    SP3:  -                                                                                                                                                   
    SP4:  -                             -                                                                                                                     
    SP5:                                                                                                        -                                             


    ECgene alternative splicing isoforms for MYRF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYRF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MYRF Expression
    About this image


    MYRF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Medulla Oblongata
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Spinal Cord White Matter
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Kidney (Urinary System)
             Renal Vesicle
     
     Eye (Sensory Organs)
             Retina
    MYRF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYRF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.473109

    UniProtKB/Swiss-Prot: MRF_HUMAN, Q9Y2G1
    Tissue specificity: Expressed in lung, ARPE-19 cell line, brainstem, uterus and, to a lesser extent, in basal
    ganglion and liver. Weakly expressed in cerebellum and retina

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYRF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MYRF gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myrf1 , 5 predicted gene 985
    myelin regulatory factor1
    86.58(n)1
    90.09(a)1
      19 (6.54 cM)5
    2259081  NM_001033481.11  NP_001028653.11 
     102082725 
    chicken
    (Gallus gallus)
    Aves C5H11ORF91 chromosome 5 open reading frame, human C11orf9 73.76(n)
    73.51(a)
      422966  XM_420899.4  XP_420899.4 
    lizard
    (Anolis carolinensis)
    Reptilia MYRF6
    myelin regulatory factor
    64(a)
    1 ↔ 1
    GL343235.1(1670051-1779263)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia myrf1 myelin regulatory factor 65.14(n)
    65.43(a)
      100486798  XM_002937648.2  XP_002937694.2 
    zebrafish
    (Danio rerio)
    Actinopterygii myrf1 myelin regulatory factor 62.41(n)
    59.86(a)
      570792  XM_005174239.1  XP_005174296.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG33286
    --
    20(a)
    1 → many
    2R(20050013-20061150)
    worm
    (Caenorhabditis elegans)
    Secernentea pqn-476
    F21A10.26
    Protein PQN-47 (pqn-47) mRNA, complete cds
    Protein F21A10.2, isoform e (F21A10.2) mRNA, compl...
    25(a)
    23(a)
    many ↔ many
    many ↔ many
    II(10497055-10502541) WBGene00004134
    X(10181139-10194377) WBGene00008999


    ENSEMBL Gene Tree for MYRF (if available)
    TreeFam Gene Tree for MYRF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYRF gene
    MYRFL2  
    1 SIMAP similar gene for MYRF using alignment to 3 protein entries:     MRF_HUMAN (see all proteins):
    MYRFL

    Find genes that share paralogs with MYRF           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYRF (see all 681)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913875471,2
    --61518224(+) TACAGA/GTGTGA 1 -- us2k10--------
    rs1984211,2
    C,F,H--61518237(-) AGGCTC/Tcagtg 1 -- us2k116Minor allele frequency- T:0.08NS EA NA 1850
    rs1840777871,2
    --61518308(+) CTACTA/GTGTGC 1 -- us2k10--------
    rs1873761521,2
    --61518592(+) GGCAGC/GTGTAG 1 -- us2k10--------
    rs1922776781,2
    --61518609(+) CATGTC/TTGAGC 1 -- us2k10--------
    rs1440239041,2
    --61518831(+) TGAGAC/TGAGAG 1 -- us2k10--------
    rs1388924131,2
    --61518872(+) GAGGCA/TGTCAG 1 -- us2k10--------
    rs1984201,2
    C,F--61518933(-) TAACTC/TGATAT 1 -- us2k12Minor allele frequency- T:0.02MN WA 302
    rs16151671,2
    C,F,A--61518986(-) TCCGAG/ACTCTC 1 -- us2k111Minor allele frequency- A:0.31NA WA CSA EA 373
    rs1420043881,2
    --61519100(+) GCCAAC/TGTGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MYRF (61520114 - 61555990 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MYRF: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYRF
    DNA2.0 Custom Variant and Variant Library Synthesis for MYRF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608329    OMIM disorders: --


    Find genes that share disorders with MYRF           About GenesLikeMe


    Export disorders for MYRF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYRF gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with MYRF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and genomic structure of a novel gene (C11orf9) localized to chromosome 11q12-->q13.1 which encodes a highly conserved, potential membrane-associated protein. (PubMed id 10828591)1, 2, 3 Stoehr H.... Weber B.H.F. (Cytogenet. Cell Genet. 2000)
    2. A bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF. (PubMed id 23966832)1, 2 Li Z.... Marcotte E.M. (PLoS Biol. 2013)
    3. Crystal structure of the DNA-binding domain from Ndt80, a transcriptional activator required for meiosis in yeast. (PubMed id 12384578)1, 3 Montano S.P....Georgiadis M.M. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    5. Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes. (PubMed id 9615227)1, 2 Cooper P.R.... Shows T.B. (Genomics 1998)
    6. Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS. (PubMed id 22956843)1 Koenning M....Emery B. (J. Neurosci. 2012)
    7. Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. (PubMed id 21829377)1 Lemaitre R.N....Steffen L.M. (PLoS Genet. 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 745 HGNC: 1181 AceView: C11orf9 Ensembl:ENSG00000124920 euGenes: HUgn745
    ECgene: MYRF H-InvDB: MYRF

    (According to HUGE)
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    HUGE: KIAA0954

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYRF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYRF gene:
    Search GeneIP for patents involving MYRF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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