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MYPOP Gene

protein-coding   GIFtS: 42
GCID: GC19M046393

Myb-Related Transcription Factor, Partner Of Profilin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myb-Related Transcription Factor, Partner Of Profilin1 2     P42pop2
Partner Of Profilin1 2 3     P42 Myb-Related Transcription Factor, Partner Of Profilin2
Myb-Related Protein P42POP2 3     P42POP3
P42 Myb-Related Transcription Factor1     

External Ids:    HGNC: 201781   Entrez Gene: 3393442   Ensembl: ENSG000001761827   UniProtKB: Q86VE03   

Export aliases for MYPOP gene to outside databases

Previous GC identifers: GC19M051086 GC19M042822


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYPOP Gene:
MYPOP (Myb-related transcription factor, partner of profilin) is a protein-coding gene. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: MYPOP_HUMAN, Q86VE0
Function: Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence
5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYPOP gene promoter:
         Tal-1   Bach2   Lmo2   XBP-1   E47   GATA-1   MZF-1   Ik-2   HOXA5   FOXO4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MYPOP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYPOP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

MYPOP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYPOP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M046393:  view genomic region     (about GC identifiers)

Start:
46,393,278 bp from pter      End:
46,405,862 bp from pter
Size:
12,585 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MYPOP_HUMAN, Q86VE0 (See protein sequence)
Recommended Name: Myb-related transcription factor, partner of profilin  
Size: 399 amino acids; 42508 Da
Subunit: Interacts with PFN1. Homodimer and heterodimer with PFN1 (By similarity)

Explore the universe of human proteins at neXtProt for MYPOP: NX_Q86VE0

Explore proteomics data for MYPOP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYPOP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001012661.1  
    ENSEMBL proteins: 
     ENSP00000325402  

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    antibodies-online kits for MYPOP (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR028002 Myb_DNA-bind_5
     IPR001005 SANT/Myb
     IPR017877 Myb-like_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q86VE0

    ProtoNet protein and cluster: Q86VE0

    UniProtKB/Swiss-Prot: MYPOP_HUMAN, Q86VE0
    Domain: The proline-rich region is required for PFN1 interaction (By similarity)
    Similarity: Contains 1 Myb-like domain


    Find genes that share domains with MYPOP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYPOP_HUMAN, Q86VE0
    Function: Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence
    5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity IEA--
         
    Find genes that share ontologies with MYPOP           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MYPOP

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    hsa-miR-3655 hsa-miR-144* hsa-miR-708* hsa-miR-197 hsa-miR-1297 hsa-miR-135b hsa-miR-1207-3p hsa-miR-26a
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYPOP_HUMAN, Q86VE0: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with MYPOP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYPOP
    Interactions:

        Search GeneGlobe Interaction Network for MYPOP

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MYPOP (Q86VE03 ENSP000003254024) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PFN1P077373, ENSP000002256554I2D: score=1 STRING: ENSP00000225655
    PFN2P350803, ENSP000002399404I2D: score=1 STRING: ENSP00000239940
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter ----

    Find genes that share ontologies with MYPOP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYPOP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYPOP gene: 
    NM_001012643.2  

    Unigene Cluster for MYPOP:

    Myb-related transcription factor, partner of profilin
    Hs.515478  [show with all ESTs]
    Unigene Representative Sequence: BC044311
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000322217(uc002pdt.3)
    miRNA
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    hsa-miR-3655 hsa-miR-144* hsa-miR-708* hsa-miR-197 hsa-miR-1297 hsa-miR-135b hsa-miR-1207-3p hsa-miR-26a
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      QuantiFast Probe-based Assays in human, mouse, rat MYPOP

    Additional mRNA sequence: BC044311.1 

    2 DOTS entries:

    DT.412562  DT.97770754 

    Selected AceView cDNA sequences (see all 36):

    AI478849 H29850 AA806692 AA307731 AA359507 BE326999 AW303394 AA744834 
    BU196283 AI478253 AI702886 AI671760 BC044311 BM666347 AI538844 BM662326 
    AI420079 AI467981 AA868704 H29940 AW134549 BM691705 R39780 BI488727 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYPOP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATTTATTA
    MYPOP Expression
    About this image

    MYPOP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYPOP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515478
        Custom PCR Arrays for MYPOP
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MYPOP gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mypop1 , 5 Myb-related transcription factor, partner of profilin1, 5 82.71(n)1
    85.11(a)1
      7 (9.45 cM)5
    2329341  NM_145579.31  NP_663554.11 
     189912455 
    lizard
    (Anolis carolinensis)
    Reptilia MYPOP6
    Myb-related transcription factor, partner of profi...
    47(a)
    1 ↔ 1
    GL344028.1(67753-75846)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986912 hypothetical protein LOC398691 74.78(n)    BC056084.1 


    ENSEMBL Gene Tree for MYPOP (if available)
    TreeFam Gene Tree for MYPOP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYPOP (see all 311)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104064921,2
    C,F,H--46392892(+) GGGAGG/ATCGAG 1 -- int112Minor allele frequency- A:0.39NA WA CSA EA 374
    rs1511930301,2
    C--46392919(+) ATCATA/GCCACT 1 -- int10--------
    rs357233171,2
    C,F--46392970(+) AAAACG/AGAAAG 1 -- int19Minor allele frequency- A:0.42NA WA CSA EA 370
    rs1910107851,2
    --46393038(+) TAAGAG/TGCAAA 1 -- int10--------
    rs771806661,2
    C--46393181(+) AAAAAG/ACTGGA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1823847921,2
    C--46393194(+) ACCACC/TAGCCT 1 -- int10--------
    rs557976121,2
    C,F--46393195(+) CCACCA/GGCCTC 1 -- int15Minor allele frequency- G:0.25NA WA EA 362
    rs1851912271,2
    --46393345(+) GCTCTA/GGAAGT 1 -- ut310--------
    rs1914760441,2
    --46393455(+) CATCCA/GTATTT 1 -- ut310--------
    rs115424891,2
    C--46393588(+) CGAGAG/AGTTCC 1 -- ut31 ese31Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for MYPOP (46393278 - 46405862 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MYPOP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2507CNV Insertion18451855
    dgv3958n71CNV Loss21882294
    nsv912172CNV Loss21882294
    nsv510770CNV Loss20534489
    dgv3956n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for MYPOP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for MYPOP:
    Spinal muscular atrophy

    Find genes that share disorders with MYPOP           About GenesLikeMe


    Export disorders for MYPOP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYPOP gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MYPOP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Profilin regulates the activity of p42POP, a novel Myb-related transcription factor. (PubMed id 15615774)1, 3 Lederer M....Rothkegel M. (J. Cell. Sci. 2005)
    2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 339344 HGNC: 20178 AceView: LOC339344 Ensembl:ENSG00000176182 euGenes: HUgn339344
    ECgene: MYPOP H-InvDB: MYPOP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYPOP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYPOP gene:
    Search GeneIP for patents involving MYPOP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     antibodies-online antibodies for MYPOP (2 products)
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      Search antibodies-online for peptides for MYPOP
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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