Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MYPOP Gene

Aliases for MYPOP Gene

  • Myb Related Transcription Factor, Partner Of Profilin 2 3 5
  • P42 Myb-Related Transcription Factor, Partner Of Profilin 2 3
  • Myb-Related Protein P42POP 3 4
  • Partner Of Profilin 3 4
  • P42pop 3 4
  • Myb-Related Transcription Factor, Partner Of Profilin 3

External Ids for MYPOP Gene

Previous GeneCards Identifiers for MYPOP Gene

  • GC19M051086
  • GC19M046393
  • GC19M042822

Summaries for MYPOP Gene

GeneCards Summary for MYPOP Gene

MYPOP (Myb Related Transcription Factor, Partner Of Profilin) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and chromatin binding.

UniProtKB/Swiss-Prot for MYPOP Gene

  • Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5-YAAC[GT]G-3. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).

Additional gene information for MYPOP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYPOP Gene

Genomics for MYPOP Gene

GeneHancer (GH) Regulatory Elements for MYPOP Gene

Promoters and enhancers for MYPOP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I045901 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 557 +0.2 191 2.3 MLX ARID4B SIN3A ZNF2 YY1 SLC30A9 POLR2B ZNF143 KLF13 SP3 MYPOP IRF2BP1
GH19I045861 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.1 +38.1 38107 5.7 MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SYMPK FOXA3 ENSG00000268810 DMWD CCDC61 CLASRP ENSG00000267114 SLC1A5 FBXO46 IRF2BP1
GH19I045927 Enhancer 1.2 Ensembl ENCODE 12.7 -25.2 -25164 1.1 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF766 E2F8 ZNF207 CCDC61 SYMPK CLASRP ENSG00000269148 ENSG00000268810 PNMA8A PPP5D1 FBXO46 MYPOP QPCTL
GH19I045952 Enhancer 1.1 Ensembl ENCODE 11.5 -52.0 -51993 4.7 ATF1 ZNF133 ARID4B SIN3A GLI4 ZNF2 ZNF766 GLIS2 ZNF213 E2F8 GC19M045925 CCDC61 MYPOP MIR769 PGLYRP1 FOXA3 SYMPK IGFL4 HIF3A DMWD
GH19I046295 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.8 -397.8 -397845 9.4 PKNOX1 ZNF133 ARID4B SIN3A ZNF121 GLIS2 KLF7 SP3 RXRA SP5 HIF3A PPP5C ENSG00000269124 FOSB IGFL3 MYPOP IRF2BP1 CCDC8 DACT3 RNU6-924P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MYPOP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MYPOP gene promoter:

Genomic Locations for MYPOP Gene

Genomic Locations for MYPOP Gene
chr19:45,890,020-45,902,696
(GRCh38/hg38)
Size:
12,677 bases
Orientation:
Minus strand
chr19:46,393,278-46,405,862
(GRCh37/hg19)

Genomic View for MYPOP Gene

Genes around MYPOP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYPOP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYPOP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYPOP Gene

Proteins for MYPOP Gene

  • Protein details for MYPOP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VE0-MYPOP_HUMAN
    Recommended name:
    Myb-related transcription factor, partner of profilin
    Protein Accession:
    Q86VE0

    Protein attributes for MYPOP Gene

    Size:
    399 amino acids
    Molecular mass:
    42508 Da
    Quaternary structure:
    • Interacts with PFN1. Homodimer and heterodimer with PFN1 (By similarity).

neXtProt entry for MYPOP Gene

Post-translational modifications for MYPOP Gene

No Post-translational modifications

Other Protein References for MYPOP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYPOP Gene

Domains & Families for MYPOP Gene

Gene Families for MYPOP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MYPOP Gene

Suggested Antigen Peptide Sequences for MYPOP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VE0

UniProtKB/Swiss-Prot:

MYPOP_HUMAN :
  • The proline-rich region is required for PFN1 interaction.
Domain:
  • The proline-rich region is required for PFN1 interaction.
genes like me logo Genes that share domains with MYPOP: view

Function for MYPOP Gene

Molecular function for MYPOP Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5-YAAC[GT]G-3. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).

Phenotypes From GWAS Catalog for MYPOP Gene

Gene Ontology (GO) - Molecular Function for MYPOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with MYPOP: view

Phenotypes for MYPOP Gene

genes like me logo Genes that share phenotypes with MYPOP: view

Animal Model Products

CRISPR Products

miRNA for MYPOP Gene

miRTarBase miRNAs that target MYPOP

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYPOP Gene

Localization for MYPOP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYPOP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYPOP gene
Compartment Confidence
nucleus 5
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYPOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MYPOP: view

Pathways & Interactions for MYPOP Gene

SuperPathways for MYPOP Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYPOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with MYPOP: view

No data available for Pathways by source and SIGNOR curated interactions for MYPOP Gene

Drugs & Compounds for MYPOP Gene

No Compound Related Data Available

Transcripts for MYPOP Gene

mRNA/cDNA for MYPOP Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(36) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYPOP Gene

Myb-related transcription factor, partner of profilin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYPOP Gene

No ASD Table

Relevant External Links for MYPOP Gene

GeneLoc Exon Structure for
MYPOP
ECgene alternative splicing isoforms for
MYPOP

Expression for MYPOP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYPOP Gene

Protein differential expression in normal tissues from HIPED for MYPOP Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYPOP Gene



Protein tissue co-expression partners for MYPOP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MYPOP Gene:

MYPOP

SOURCE GeneReport for Unigene cluster for MYPOP Gene:

Hs.515478

Evidence on tissue expression from TISSUES for MYPOP Gene

  • Blood(4)
genes like me logo Genes that share expression patterns with MYPOP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYPOP Gene

Orthologs for MYPOP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYPOP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYPOP 33 34
  • 98.21 (n)
dog
(Canis familiaris)
Mammalia MYPOP 33 34
  • 86.6 (n)
cow
(Bos Taurus)
Mammalia MYPOP 33 34
  • 86.48 (n)
rat
(Rattus norvegicus)
Mammalia Mypop 33
  • 83.33 (n)
mouse
(Mus musculus)
Mammalia Mypop 33 16 34
  • 82.71 (n)
oppossum
(Monodelphis domestica)
Mammalia MYPOP 34
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYPOP 34
  • 47 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398691 33
Species where no ortholog for MYPOP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MYPOP Gene

ENSEMBL:
Gene Tree for MYPOP (if available)
TreeFam:
Gene Tree for MYPOP (if available)

Paralogs for MYPOP Gene

No data available for Paralogs for MYPOP Gene

Variants for MYPOP Gene

Sequence variations from dbSNP and Humsavar for MYPOP Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000101153 -- 45,902,740(-) T/G upstream_transcript_variant
rs1000121350 -- 45,894,425(-) T/C intron_variant
rs1000466884 -- 45,894,635(-) C/T intron_variant
rs1000687419 -- 45,899,400(-) A/G intron_variant
rs1000942052 -- 45,889,754(-) A/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MYPOP Gene

Variant ID Type Subtype PubMed ID
nsv1071539 CNV deletion 25765185
nsv2507 CNV insertion 18451855
nsv510770 CNV deletion 20534489

Variation tolerance for MYPOP Gene

Gene Damage Index Score: 2.87; 48.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYPOP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYPOP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYPOP Gene

Disorders for MYPOP Gene

Additional Disease Information for MYPOP

No disorders were found for MYPOP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYPOP Gene

Publications for MYPOP Gene

  1. Profilin regulates the activity of p42POP, a novel Myb-related transcription factor. (PMID: 15615774) Lederer M … Rothkegel M (Journal of cell science 2005) 2 3 58
  2. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G … Cagney G (Scientific reports 2015) 3 58
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for MYPOP Gene

Sources for MYPOP Gene

Content
Loading form....