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Aliases for MYPOP Gene

Aliases for MYPOP Gene

  • Myb-Related Transcription Factor, Partner Of Profilin 2 3
  • Partner Of Profilin 2 3 4
  • Myb-Related Protein P42POP 3 4
  • P42pop 3 4
  • P42 Myb-Related Transcription Factor, Partner Of Profilin 3
  • P42 Myb-Related Transcription Factor 2

External Ids for MYPOP Gene

Summaries for MYPOP Gene

GeneCards Summary for MYPOP Gene

MYPOP (Myb-Related Transcription Factor, Partner Of Profilin) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding.

UniProtKB/Swiss-Prot for MYPOP Gene

  • Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5-YAAC[GT]G-3. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYPOP Gene

Genomics for MYPOP Gene

Genomic Location for MYPOP Gene

Start:
45,890,020 bp from pter
End:
45,902,604 bp from pter
Size:
12,585 bases
Orientation:
Minus strand

Genomic View for MYPOP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYPOP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYPOP Gene

Regulatory Elements for MYPOP Gene

Proteins for MYPOP Gene

  • Protein details for MYPOP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VE0-MYPOP_HUMAN
    Recommended name:
    Myb-related transcription factor, partner of profilin
    Protein Accession:
    Q86VE0
    Secondary Accessions:

    Protein attributes for MYPOP Gene

    Size:
    399 amino acids
    Molecular mass:
    42508 Da
    Quaternary structure:
    • Interacts with PFN1. Homodimer and heterodimer with PFN1 (By similarity).

neXtProt entry for MYPOP Gene

Proteomics data for MYPOP Gene at MOPED

Post-translational modifications for MYPOP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYPOP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYPOP Gene

Domains for MYPOP Gene

Protein Domains for MYPOP Gene

UniProtKB/Swiss-Prot:

MYPOP_HUMAN
Domain:
  • The proline-rich region is required for PFN1 interaction.:
    • Q86VE0
  • Contains 1 Myb-like domain.:
    • Q86VE0
genes like me logo Genes that share domains with MYPOP: view

No data available for Gene Families for MYPOP Gene

Function for MYPOP Gene

Molecular function for MYPOP Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5-YAAC[GT]G-3. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).

Gene Ontology (GO) - Molecular Function for MYPOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
genes like me logo Genes that share ontologies with MYPOP: view

miRNA for MYPOP Gene

miRTarBase miRNAs that target MYPOP

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MYPOP Gene

Localization for MYPOP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYPOP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYPOP Gene COMPARTMENTS Subcellular localization image for MYPOP gene
Compartment Confidence
nucleus 3
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MYPOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MYPOP: view

Pathways for MYPOP Gene

SuperPathways for MYPOP Gene

No Data Available

Interacting Proteins for MYPOP Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000325402%0d%0a9606.ENSP00000225655%0d%0a9606.ENSP00000239940%0d%0a
Selected Interacting proteins: ENSP00000325402 Q86VE0-MYPOP_HUMAN for MYPOP Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MYPOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
genes like me logo Genes that share ontologies with MYPOP: view

No data available for Pathways by source for MYPOP Gene

Transcripts for MYPOP Gene

mRNA/cDNA for MYPOP Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(36) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYPOP Gene

Myb-related transcription factor, partner of profilin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYPOP Gene

No ASD Table

Relevant External Links for MYPOP Gene

GeneLoc Exon Structure for
MYPOP
ECgene alternative splicing isoforms for
MYPOP

Expression for MYPOP Gene

mRNA expression in normal human tissues for MYPOP Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MYPOP Gene

SOURCE GeneReport for Unigene cluster for MYPOP Gene Hs.515478

genes like me logo Genes that share expressions with MYPOP: view

Orthologs for MYPOP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYPOP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYPOP 36
  • 98.21 (n)
  • 97.31 (a)
MYPOP 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYPOP 36
  • 86.48 (n)
  • 88.89 (a)
MYPOP 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYPOP 36
  • 86.6 (n)
  • 89.18 (a)
MYPOP 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mypop 36
  • 82.71 (n)
  • 85.11 (a)
Mypop 16
Mypop 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYPOP 37
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mypop 36
  • 83.33 (n)
  • 85.9 (a)
lizard
(Anolis carolinensis)
Reptilia MYPOP 37
  • 47 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398691 36
Species with no ortholog for MYPOP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MYPOP Gene

ENSEMBL:
Gene Tree for MYPOP (if available)
TreeFam:
Gene Tree for MYPOP (if available)

Paralogs for MYPOP Gene

No data available for Paralogs for MYPOP Gene

Variants for MYPOP Gene

Sequence variations from dbSNP and Humsavar for MYPOP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2080968 -- 45,891,982(-) agatc(A/G)cgcca intron-variant
rs3051357 -- 45,900,455(+) CCCCC(-/GC)CCCCC intron-variant
rs8102437 -- 45,896,641(+) tgaga(C/T)ggagt intron-variant
rs8103923 -- 45,899,125(+) ggagg(A/G)tgagg intron-variant
rs8105375 -- 45,894,273(+) acgcc(C/T)ggcta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYPOP Gene

Variant ID Type Subtype PubMed ID
dgv3956n71 CNV Loss 21882294
nsv912172 CNV Loss 21882294
nsv510770 CNV Loss 20534489
dgv3958n71 CNV Loss 21882294
nsv2507 CNV Insertion 18451855

Relevant External Links for MYPOP Gene

HapMap Linkage Disequilibrium report
MYPOP

Disorders for MYPOP Gene

(1) University of Copenhagen DISEASES for MYPOP Gene

genes like me logo Genes that share disorders with MYPOP: view

No data available for UniProtKB/Swiss-Prot for MYPOP Gene

Publications for MYPOP Gene

  1. Profilin regulates the activity of p42POP, a novel Myb-related transcription factor. (PMID: 15615774) Lederer M. … Rothkegel M. (J. Cell. Sci. 2005) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MYPOP Gene

Sources for MYPOP Gene

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