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Aliases for MYPOP Gene

Aliases for MYPOP Gene

  • Myb Related Transcription Factor, Partner Of Profilin 2 3 5
  • P42 Myb-Related Transcription Factor, Partner Of Profilin 2 3
  • Myb-Related Protein P42POP 3 4
  • Partner Of Profilin 3 4
  • P42pop 3 4
  • Myb-Related Transcription Factor, Partner Of Profilin 3

External Ids for MYPOP Gene

Previous GeneCards Identifiers for MYPOP Gene

  • GC19M051086
  • GC19M046393
  • GC19M042822

Summaries for MYPOP Gene

GeneCards Summary for MYPOP Gene

MYPOP (Myb Related Transcription Factor, Partner Of Profilin) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding.

UniProtKB/Swiss-Prot for MYPOP Gene

  • Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5-YAAC[GT]G-3. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).

Additional gene information for MYPOP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYPOP Gene

Genomics for MYPOP Gene

Regulatory Elements for MYPOP Gene

Enhancers for MYPOP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H045861 1.7 Ensembl ENCODE dbSUPER 11.1 +38.1 38108 5 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000268810 DMWD SYMPK CCDC61 CLASRP ENSG00000267114 RPS16P9 SLC1A5 FBXO46 IRF2BP1
GH19H045927 1.3 Ensembl ENCODE 12.7 -25.2 -25165 1 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF207 ZNF143 FOS SYMPK CCDC61 CLASRP ENSG00000268810 PNMA8A PPP5D1 MYPOP QPCTL IRF2BP1 FOXA3
GH19H045952 1.2 Ensembl ENCODE 11.5 -52.0 -51993 4 ATF1 ZNF133 ARID4B SIN3A GLI4 ZNF2 ZNF766 GLIS2 ZNF143 ATF7 CCDC61 MYPOP MIR769 PGLYRP1 SYMPK FOXA3 IGFL4 HIF3A DMWD ERCC1
GH19H045901 1 ENCODE 7 +0.2 192 2 MLX ARID4B SIN3A ZNF2 YY1 SLC30A9 GLIS2 ZNF143 ATF7 RUNX3 MYPOP IRF2BP1
GH19H046295 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.8 -397.8 -397845 9 PKNOX1 ZNF133 ARID4B ZNF121 GLIS2 KLF7 SP3 SP5 NFYC REST PPP5C HIF3A ENSG00000269124 FOSB IGFL3 MYPOP IRF2BP1 CCDC8 DACT3 GC19M046308
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYPOP on UCSC Golden Path with GeneCards custom track

Promoters for MYPOP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110287 196 2201 MLX ARID4B SIN3A ZNF2 YY1 SLC30A9 GLIS2 GATA2 ZNF143 ATF7

Genomic Location for MYPOP Gene

Chromosome:
19
Start:
45,890,020 bp from pter
End:
45,902,696 bp from pter
Size:
12,677 bases
Orientation:
Minus strand

Genomic View for MYPOP Gene

Genes around MYPOP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYPOP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYPOP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYPOP Gene

Proteins for MYPOP Gene

  • Protein details for MYPOP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VE0-MYPOP_HUMAN
    Recommended name:
    Myb-related transcription factor, partner of profilin
    Protein Accession:
    Q86VE0

    Protein attributes for MYPOP Gene

    Size:
    399 amino acids
    Molecular mass:
    42508 Da
    Quaternary structure:
    • Interacts with PFN1. Homodimer and heterodimer with PFN1 (By similarity).

neXtProt entry for MYPOP Gene

Post-translational modifications for MYPOP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYPOP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYPOP Gene

Domains & Families for MYPOP Gene

Gene Families for MYPOP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MYPOP Gene

Suggested Antigen Peptide Sequences for MYPOP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VE0

UniProtKB/Swiss-Prot:

MYPOP_HUMAN :
  • The proline-rich region is required for PFN1 interaction.
Domain:
  • The proline-rich region is required for PFN1 interaction.
genes like me logo Genes that share domains with MYPOP: view

Function for MYPOP Gene

Molecular function for MYPOP Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5-YAAC[GT]G-3. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).

Phenotypes From GWAS Catalog for MYPOP Gene

Gene Ontology (GO) - Molecular Function for MYPOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with MYPOP: view

Phenotypes for MYPOP Gene

genes like me logo Genes that share phenotypes with MYPOP: view

Animal Model Products

CRISPR Products

miRNA for MYPOP Gene

miRTarBase miRNAs that target MYPOP

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MYPOP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYPOP Gene

Localization for MYPOP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYPOP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYPOP gene
Compartment Confidence
nucleus 5
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYPOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MYPOP: view

Pathways & Interactions for MYPOP Gene

SuperPathways for MYPOP Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYPOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with MYPOP: view

No data available for Pathways by source and SIGNOR curated interactions for MYPOP Gene

Drugs & Compounds for MYPOP Gene

No Compound Related Data Available

Transcripts for MYPOP Gene

mRNA/cDNA for MYPOP Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(36) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYPOP Gene

Myb-related transcription factor, partner of profilin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MYPOP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MYPOP Gene

No ASD Table

Relevant External Links for MYPOP Gene

GeneLoc Exon Structure for
MYPOP
ECgene alternative splicing isoforms for
MYPOP

Expression for MYPOP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYPOP Gene

Protein differential expression in normal tissues from HIPED for MYPOP Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYPOP Gene



Protein tissue co-expression partners for MYPOP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MYPOP Gene:

MYPOP

SOURCE GeneReport for Unigene cluster for MYPOP Gene:

Hs.515478

Evidence on tissue expression from TISSUES for MYPOP Gene

  • Blood(4)
genes like me logo Genes that share expression patterns with MYPOP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYPOP Gene

Orthologs for MYPOP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYPOP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYPOP 33 34
  • 98.21 (n)
dog
(Canis familiaris)
Mammalia MYPOP 33 34
  • 86.6 (n)
cow
(Bos Taurus)
Mammalia MYPOP 33 34
  • 86.48 (n)
rat
(Rattus norvegicus)
Mammalia Mypop 33
  • 83.33 (n)
mouse
(Mus musculus)
Mammalia Mypop 33 16 34
  • 82.71 (n)
oppossum
(Monodelphis domestica)
Mammalia MYPOP 34
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYPOP 34
  • 47 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398691 33
Species where no ortholog for MYPOP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MYPOP Gene

ENSEMBL:
Gene Tree for MYPOP (if available)
TreeFam:
Gene Tree for MYPOP (if available)

Paralogs for MYPOP Gene

No data available for Paralogs for MYPOP Gene

Variants for MYPOP Gene

Sequence variations from dbSNP and Humsavar for MYPOP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000101153 -- 45,902,740(+) TTCAT(G/T)CCCAC upstream-variant-2KB
rs1000121350 -- 45,894,425(+) TCATC(C/T)TTTTT intron-variant
rs1000466884 -- 45,894,635(+) TCAAA(C/T)TCCTG intron-variant
rs1000687419 -- 45,899,400(+) AAAAA(A/G)TAAGT intron-variant
rs1000942052 -- 45,889,754(+) GAACC(A/C)CAGGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MYPOP Gene

Variant ID Type Subtype PubMed ID
nsv1071539 CNV deletion 25765185
nsv2507 CNV insertion 18451855
nsv510770 CNV deletion 20534489

Variation tolerance for MYPOP Gene

Gene Damage Index Score: 2.87; 48.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYPOP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYPOP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYPOP Gene

Disorders for MYPOP Gene

Relevant External Links for MYPOP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYPOP

No disorders were found for MYPOP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYPOP Gene

Publications for MYPOP Gene

  1. Profilin regulates the activity of p42POP, a novel Myb-related transcription factor. (PMID: 15615774) Lederer M … Rothkegel M (Journal of cell science 2005) 2 3 60
  2. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G … Cagney G (Scientific reports 2015) 3 60
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for MYPOP Gene

Sources for MYPOP Gene

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