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Aliases for MYPOP Gene

Aliases for MYPOP Gene

  • Myb-Related Transcription Factor, Partner Of Profilin 2 3
  • Partner Of Profilin 2 3 4
  • Myb-Related Protein P42POP 3 4
  • P42pop 3 4
  • P42 Myb-Related Transcription Factor, Partner Of Profilin 3
  • P42 Myb-Related Transcription Factor 2

External Ids for MYPOP Gene

Previous GeneCards Identifiers for MYPOP Gene

  • GC19M051086
  • GC19M046393
  • GC19M042822

Summaries for MYPOP Gene

GeneCards Summary for MYPOP Gene

MYPOP (Myb-Related Transcription Factor, Partner Of Profilin) is a Protein Coding gene. Diseases associated with MYPOP include proximal myopathy and ophthalmoplegia. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding.

UniProtKB/Swiss-Prot for MYPOP Gene

  • Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5-YAAC[GT]G-3. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYPOP Gene

Genomics for MYPOP Gene

Regulatory Elements for MYPOP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MYPOP Gene

Chromosome:
19
Start:
45,890,020 bp from pter
End:
45,902,696 bp from pter
Size:
12,677 bases
Orientation:
Minus strand

Genomic View for MYPOP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYPOP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYPOP Gene

Proteins for MYPOP Gene

  • Protein details for MYPOP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VE0-MYPOP_HUMAN
    Recommended name:
    Myb-related transcription factor, partner of profilin
    Protein Accession:
    Q86VE0

    Protein attributes for MYPOP Gene

    Size:
    399 amino acids
    Molecular mass:
    42508 Da
    Quaternary structure:
    • Interacts with PFN1. Homodimer and heterodimer with PFN1 (By similarity).

neXtProt entry for MYPOP Gene

Proteomics data for MYPOP Gene at MOPED

Post-translational modifications for MYPOP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYPOP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYPOP Gene

Domains & Families for MYPOP Gene

Gene Families for MYPOP Gene

Protein Domains for MYPOP Gene

Suggested Antigen Peptide Sequences for MYPOP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VE0

UniProtKB/Swiss-Prot:

MYPOP_HUMAN :
  • The proline-rich region is required for PFN1 interaction.
Domain:
  • The proline-rich region is required for PFN1 interaction.
  • Contains 1 Myb-like domain.
genes like me logo Genes that share domains with MYPOP: view

Function for MYPOP Gene

Molecular function for MYPOP Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5-YAAC[GT]G-3. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).

Gene Ontology (GO) - Molecular Function for MYPOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with MYPOP: view

Phenotypes for MYPOP Gene

GenomeRNAi human phenotypes for MYPOP:
genes like me logo Genes that share phenotypes with MYPOP: view

Animal Model Products

miRNA for MYPOP Gene

miRTarBase miRNAs that target MYPOP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MYPOP Gene

Localization for MYPOP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYPOP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYPOP Gene COMPARTMENTS Subcellular localization image for MYPOP gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for MYPOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MYPOP: view

Pathways & Interactions for MYPOP Gene

SuperPathways for MYPOP Gene

No Data Available

Interacting Proteins for MYPOP Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000325402%0d%0a9606.ENSP00000225655%0d%0a9606.ENSP00000239940%0d%0a
Selected Interacting proteins: Q86VE0-MYPOP_HUMAN ENSP00000325402 for MYPOP Gene via I2D STRING

Gene Ontology (GO) - Biological Process for MYPOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
genes like me logo Genes that share ontologies with MYPOP: view

No data available for Pathways by source and SIGNOR curated interactions for MYPOP Gene

Drugs & Compounds for MYPOP Gene

No Compound Related Data Available

Transcripts for MYPOP Gene

mRNA/cDNA for MYPOP Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(36) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYPOP Gene

Myb-related transcription factor, partner of profilin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYPOP Gene

No ASD Table

Relevant External Links for MYPOP Gene

GeneLoc Exon Structure for
MYPOP
ECgene alternative splicing isoforms for
MYPOP

Expression for MYPOP Gene

mRNA expression in normal human tissues for MYPOP Gene

Protein differential expression in normal tissues from HIPED for MYPOP Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MYPOP Gene



SOURCE GeneReport for Unigene cluster for MYPOP Gene Hs.515478

genes like me logo Genes that share expression patterns with MYPOP: view

Protein tissue co-expression partners for MYPOP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MYPOP Gene

Orthologs for MYPOP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYPOP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYPOP 35
  • 86.48 (n)
  • 88.89 (a)
MYPOP 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYPOP 35
  • 86.6 (n)
  • 89.18 (a)
MYPOP 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mypop 35
  • 82.71 (n)
  • 85.11 (a)
Mypop 16
Mypop 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYPOP 35
  • 98.21 (n)
  • 97.31 (a)
MYPOP 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mypop 35
  • 83.33 (n)
  • 85.9 (a)
oppossum
(Monodelphis domestica)
Mammalia MYPOP 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYPOP 36
  • 47 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398691 35
Species with no ortholog for MYPOP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MYPOP Gene

ENSEMBL:
Gene Tree for MYPOP (if available)
TreeFam:
Gene Tree for MYPOP (if available)

Paralogs for MYPOP Gene

No data available for Paralogs for MYPOP Gene

Variants for MYPOP Gene

Sequence variations from dbSNP and Humsavar for MYPOP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs376217965 -- 45,898,200(+) GATTA(C/T)AGGCA intron-variant
rs376399863 -- 45,896,078(+) CTGAG(A/G)TCAGG intron-variant
rs376515201 -- 45,889,636(+) GAGAT(C/T)GAGGC downstream-variant-500B
rs376664151 -- 45,896,712(+) GCTCC(A/G)CTTCC intron-variant
rs376978103 -- 45,894,920(+) CACCA(C/T)GTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYPOP Gene

Variant ID Type Subtype PubMed ID
dgv3956n71 CNV Loss 21882294
nsv912172 CNV Loss 21882294
nsv510770 CNV Loss 20534489
dgv3958n71 CNV Loss 21882294
nsv2507 CNV Insertion 18451855

Variation tolerance for MYPOP Gene

Gene Damage Index Score: 2.87; 48.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYPOP Gene

HapMap Linkage Disequilibrium report
MYPOP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYPOP Gene

Disorders for MYPOP Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYPOP Gene - From: OMIM

Disorder Aliases PubMed IDs
proximal myopathy and ophthalmoplegia
  • inclusion body myopathy 3
- elite association
Search MYPOP in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYPOP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYPOP
genes like me logo Genes that share disorders with MYPOP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYPOP Gene

Publications for MYPOP Gene

  1. Profilin regulates the activity of p42POP, a novel Myb-related transcription factor. (PMID: 15615774) Lederer M. … Rothkegel M. (J. Cell. Sci. 2005) 2 67
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for MYPOP Gene

Sources for MYPOP Gene

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