Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYPN Gene

protein-coding   GIFtS: 51
GCID: GC10P069865

myopalladin

 Explore 11 diseases affiliated with
MYPN via our new
 Human Malady Compendium 
Biological research products
for MYPN
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Myopalladin1
MYOP1 2 3
Sarcomeric Protein Myopalladin, 145 KDa (MYOP)2
145 KDa Sarcomeric Protein3

External Ids:    HGNC: 232461   Entrez Gene: 846652   Ensembl: ENSG000001383477   OMIM: 6085175   UniProtKB: Q86TC93   

Export aliases for MYPN gene to outside databases

Previous GC identifers: GC10P069213 GC10P069535 GC10P063869


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYPN:
Striated muscle in vertebrates comprises large proteins which must be organized properly to contract efficiently.
Z-lines in striated muscle are a sign of this organization, representing the ends of actin thin filaments, titin,
nebulin or nebulette and accessory proteins required for structure and function. This gene encodes a protein which
interacts with nebulin in skeletal muscle or nebulette in cardiac muscle and alpha-actinin. In addition, this gene
product can interact with a protein with the I-band indicating it has a regulatory as well as structural function.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: MYPN_HUMAN, Q86TC9
Function: Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to
alpha-actinin, at the Z lines

Gene Wiki entry for MYPN


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYPN gene promoter:
         NF-1   Pax-5   FOXL1   POU2F1   CBF-B   CBF-A   POU2F1a   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYPN promoter sequence
   Search SABiosciences Chromatin IP Primers for MYPN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYPN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.3   Ensembl cytogenetic band:  10q21.3   HGNC cytogenetic band: 10q22.1

MYPN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYPN gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P069865:  view genomic region     (about GC identifiers)

Start:
69,865,912 bp from pter      End:
69,971,774 bp from pter
Size:
105,863 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MYPN_HUMAN, Q86TC9 (See protein sequence)
Recommended Name: Myopalladin  
Size: 1320 amino acids; 145257 Da
Subunit: Interacts with TTN/titin, NEB, NEBL, ACTN2 and CARP
Subcellular location: Cytoplasm. Nucleus (By similarity). Cytoplasm, myofibril, sarcomere. Note=Bound to sarcomere both
at the Z-line periphery and in the central I-band region
Sequence caution: Sequence=CAD38923.2; Type=Erroneous initiation;
Secondary accessions: Q5VV35 Q5VV36 Q86T37 Q8N3L4 Q96K90 Q96KF5
Alternative splicing: 3 isoforms:  Q86TC9-1   Q86TC9-2   Q86TC9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYPN: NX_Q86TC9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86TC9

  • MYPN Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243196.1  NP_001243197.1  NP_115967.2  

    ENSEMBL proteins: 
     ENSP00000346369   ENSP00000351790   ENSP00000362779   ENSP00000441668  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: MYPN
    OriGene Custom Protein Services for MYPN 
    GenScript Custom Purified and Recombinant Proteins Services for MYPN
    Novus Biologicals MYPN Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MYPN

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0015630microtubule cytoskeleton IDA--
    GO:0030018colocalizes with Z disc IDA11309420
    GO:0031674I band IDA11309420


    MYPN for ontologies           About GeneDecksing



    MYPN Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MYPN 
    GenScript Custom Superior Antibodies Services for MYPN
    Novus Biologicals MYPN Antibodies
    Search for Antibodies for MYPN at Abcam  
    Uscn Antibodies for MYPN
    Search ThermoFisher Antibodies for MYPN

    Assay Products for MYPN: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYPN
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MYPN


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MYPN for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q86TC9

    ProtoNet protein and cluster: Q86TC9

    2 Blocks protein families:
    IPB003598 Immunoglobulin C-2 type
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: MYPN_HUMAN, Q86TC9
    Similarity: Belongs to the myotilin/palladin family
    Similarity: Contains 5 Ig-like (immunoglobulin-like) domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MYPN_HUMAN, Q86TC9
    Function: Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to
    alpha-actinin, at the Z lines

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: MYPN
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYPN
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate MYPN (see all 25):
    hsa-miR-498 hsa-miR-875-3p hsa-miR-218-1* hsa-miR-4263 hsa-miR-1244 hsa-miR-9 hsa-miR-550b hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidMYPN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYPN (see all 4)
    OriGene shRNA RFP: MYPN
    OriGene siRNA: MYPN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYPN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYPN

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYPN (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYPN
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MYPN (NM_032578)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYPN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYPN 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MYPN
    Search LifeMap BioReagents cell lines for MYPN

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYPN

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI11309420
    GO:0008092cytoskeletal protein binding IPI11309420
    GO:0017124SH3 domain binding IPI11309420
    GO:0051371muscle alpha-actinin binding IPI11309420


    MYPN for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYPN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/10 Interacting proteins for MYPN (Q86TC92, 3 ENSP000003517904) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEBP209292, 3, ENSP000003862594MINT-7032393 MINT-7032374 I2D: score=3 STRING: ENSP00000386259
    ACTN2P356093, ENSP000003555374I2D: score=2 STRING: ENSP00000355537
    ANKRD1Q153273, ENSP000003607624I2D: score=2 STRING: ENSP00000360762
    NEBLO760413, ENSP000003663264I2D: score=2 STRING: ENSP00000366326
    ANKRD23Q86SG23, ENSP000003216794I2D: score=2 STRING: ENSP00000321679
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045214sarcomere organization IMP11309420


    MYPN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MYPN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MYPN
    1 Novoseek chemical compound relationship for MYPN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 1 16902413 (1)

    Search CenterWatch for drugs/clinical trials and news about MYPN 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYPN gene (3 alternative transcripts): 
    NM_001256267.1  NM_001256268.1  NM_032578.3  

    Unigene Cluster for MYPN:

    Myopalladin
    Hs.55205  [show with all ESTs]
    Unigene Representative Sequence: NM_001256268
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354393 ENST00000358913(uc001jnl.1 uc001jnm.4 uc001jnn.4 uc001jno.4 uc009xps.3 uc009xpt.3 uc010qit.2 uc010qiu.2)
    ENST00000373675(uc001jnp.1) ENST00000540630

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: MYPN
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYPN
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate MYPN (see all 25):
    hsa-miR-498 hsa-miR-875-3p hsa-miR-218-1* hsa-miR-4263 hsa-miR-1244 hsa-miR-9 hsa-miR-550b hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidMYPN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYPN (see all 4)
    OriGene shRNA RFP: MYPN
    OriGene siRNA: MYPN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYPN
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYPN (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYPN
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MYPN (NM_032578)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYPN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYPN 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYPN
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYPN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYPN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYPN

    Additional cDNA sequence: 

    AF328296.1 AL832002.2 AL832379.1 AL834247.2 BC142609.1 BC144333.1 BC144334.1 BX647637.1 
    BX647640.1 BX648564.1 NR_045662.3 NR_045663.3 

    7 DOTS entries:

    DT.95364444  DT.97762529  DT.95153656  DT.100755009  DT.121298069  DT.95153655  DT.121298113 

    24/66 AceView cDNA sequences (see all 66):

    CD634139 F16301 BF826605 BX500271 CD634134 CB136621 BI000763 AL832379 
    BF826659 BF836591 AL598047 CD634127 BQ359306 CD634128 BM721886 BF109970 
    BX647640 CD634131 F24218 AL834247 CD634133 AA179599 CD634140 NM_032578 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYPN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCTCCTGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    MYPN expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod Growth PlateBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MYPN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYPN

    SOURCE GeneReport for Unigene cluster: Hs.55205

    UniProtKB/Swiss-Prot: MYPN_HUMAN, Q86TC9
    Tissue specificity: Expressed in adult skeletal muscle and fetal heart

        SABiosciences Custom PCR Arrays for MYPN
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYPN
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYPN
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYPN
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYPN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYPN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MYPN gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves MYPN1 myopalladin 70.37(n)
    68.61(a)
      423684  XM_421565.3  XP_421565.3 
    lizard
    (Anolis carolinensis)
    Reptilia MYPN6
    --
    69(a)
    1 ↔ 1
    GL343215.1(1389227-1438920)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.144632 Xenopus laevis transcribed sequence with moderate similarity more 74.59(n)    BJ071900.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mypn1 myopalladin 59.8(n)
    59.19(a)
      571695  XM_695308.5  XP_700400.5 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-896
    Muscle M-line assembly protein unc-89
    4(a)
    possible ortholog
    I(4035746-4090963)


    ENSEMBL Gene Tree for MYPN (if available)
    TreeFam Gene Tree for MYPN (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYPN gene
    MYOT2  PALLD2  
    9 SIMAP similar genes for MYPN using alignment to 5 protein entries:     MYPN_HUMAN (see all proteins):
    DKFZp586L0518    DKFZp686I10125    KIAA0992    PALLD    PTPRF    MYLK
    MYOT    PTPRS    MUSK

    MYPN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2296 NCBI SNPs in MYPN are shown (see all 2296    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1401481051,2
    C,F,untested63881092(+) GAGCTA/GTTTAG 7 Y C nc-transcript-variantut51 int1 mis12Minor allele frequency- G:0.00NA EU 5875
    rs715789891,2
    Cuntested63881281(+) GGCCA-/TCAATT 7 T I fra1 ut51 int10--------
    rs715789901,2
    Cuntested63881453(+) CAGTAC/TTGTTC 7 Y nc-transcript-variantint1 ut51 syn10--------
    rs1428670011,2
    C,F,untested63881498(+) GCTGCC/GGACTT 7 A syn1 int1 ut511Minor allele frequency- G:0.00NA 4480
    rs741430221,2
    C,F,untested63881876(+) GTTCCA/GGAAGG 7 P int1 ut51 nc-transcript-variantsyn13Minor allele frequency- G:0.04WA NA 3998
    rs1447649831,2
    C,F,untested63905091(+) GAAGGC/TGACCC 8 G nc-transcript-variantsyn12Minor allele frequency- T:0.00NA EU 5791
    rs115966531,2
    C,F,A,H,untested63907991(+) TGCAGT/CCATTC 8 /A /V mis124Minor allele frequency- C:0.13NS EA NA WA CSA EU 8189
    rs109979481,2
    C,F,H,untested63909636(+) TGTCAG/AAGCCC 8 /Q syn1 ese326Minor allele frequency- A:0.10NS EA NA CSA WA EU 8492
    rs741430301,2
    C,F,untested63918156(+) AGGTTG/AAGTGG 8 /K /E mis14Minor allele frequency- A:0.05WA NA EU 5985
    rs715844881,2
    Cuntested63925935(+) CTGGCA/CGCTAT 8 A syn10--------

    HapMap Linkage Disequilibrium report for MYPN (69865912 - 69971774 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MYPN: --
    Human Gene Mutation Database (HGMD): MYPN

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYPN
    DNA2.0 Custom Variant and Variant Library Synthesis for MYPN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MYPN for disorders           About GeneDecksing

    OMIM gene information: 608517    OMIM disorders: --

    11 diseases for MYPN:    About MalaCards
    tibial muscular dystrophy    nemaline myopathy    muscular dystrophy    hypertrophic cardiomyopathy
    dilated cardiomyopathy    cardiomyopathy    paralysis    alzheimer's disease
    myopathy    pharyngitis    hypoxia

    Human Genome Epidemiology (HuGE) Navigator: MYPN (2 documents)

    Export disorders for MYPN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYPN gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with MYPN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin. (PubMed id 12482578)1, 2, 3, 9 Ma K. and Wang K. (2002)
    2. Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies. (PubMed id 11309420)1, 2, 3 Bang M.-L.... Labeit S. (2001)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    5. The palladin/myotilin/myopalladin family of actin-associated scaffolds. (PubMed id 16164966)1, 9 Otey C.A....Carpen O. (2005)
    6. Mutations in the Z-band protein myopalladin gene and idiopathic dilated cardiomyopathy. (PubMed id 18006477)1, 9 Duboscq-Bidot L....Villard E. (2008)
    7. Cytoplasmic Ig-domain proteins: cytoskeletal regulato rs with a role in human disease. (PubMed id 19466753)1, 9 Otey C.A....Goicoechea S.M. (2009)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Molecular basis for clinical heterogeneity in inherite d cardiomyopathies due to myopalladin mutations. (PubMed id 22286171)1 Purevjav E....Towbin J.A. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84665 HGNC: 23246 AceView: MYPN Ensembl:ENSG00000138347 euGenes: HUgn84665
    ECgene: MYPN H-InvDB: MYPN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYPN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYPN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYPN gene:
    Search GeneIP for patents involving MYPN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for MYPN  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYPN   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYPN  
     OriGene Protein Over-expression Lysate for MYPN   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for MYPN   OriGene 3'-UTR Clone for MYPN  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYPN   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYPN  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MYPN   OriGene Custom Protein Services for MYPN  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MYPN
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYPN
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYPN
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYPN
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYPN
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYPN
     GenScript Custom Purified and Recombinant Proteins Services for MYPN GenScript cDNA clones with any tag delivered in your preferred vector for MYPN
     GenScript Custom Assay Services for MYPN GenScript Custom Superior Antibodies Services for MYPN
     GenScript Custom overexpressing Cell Line Services for MYPN CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MYPN promoter
     Search Chromatin IP Primers for MYPN
     RT2 qPCR Primer Assay in human, mouse, rat MYPN
     GNC Network for MYPN
     SABiosciences Custom PCR Arrays for MYPN
     Search Tocris compounds for MYPN
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MYPN antibodies
     MYPN proteins
     Search for Antibodies for MYPN at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MYPN
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     MYPN Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for MYPN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYPN
     SwitchGear 3'UTR luciferase reporter plasmids for MYPN
     SwitchGear Promoter luciferase reporter plasmids for MYPN
     Search ThermoFisher Antibodies for MYPN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYPN
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MYPN gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4