Aliases for MYPN Gene
External Ids for MYPN Gene
Previous GeneCards Identifiers for MYPN Gene
Striated muscle in vertebrates comprises large proteins which must be organized properly to contract efficiently. Z-lines in striated muscle are a sign of this organization, representing the ends of actin thin filaments, titin, nebulin or nebulette and accessory proteins required for structure and function. This gene encodes a protein which interacts with nebulin in skeletal muscle or nebulette in cardiac muscle and alpha-actinin. In addition, this gene product can interact with a protein with the I-band indicating it has a regulatory as well as structural function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
GeneCards Summary for MYPN Gene
MYPN (Myopalladin) is a Protein Coding gene. Diseases associated with MYPN include cardiomyopathy, dilated, 1kk and mypn-related cardiomyopathy. GO annotations related to this gene include actin binding and cytoskeletal protein binding. An important paralog of this gene is PALLD.
UniProtKB/Swiss-Prot for MYPN Gene
Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.