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Aliases for MYOZ3 Gene

Aliases for MYOZ3 Gene

  • Myozenin 3 2 3
  • FRP3 3 4 6
  • FATZ-Related Protein 3 3 4
  • Calsarcin-3 3 4
  • FATZ Related Protein 3 2
  • Calsarcin 3 2
  • Myozenin-3 3
  • CS-3 3
  • CS3 3

External Ids for MYOZ3 Gene

Previous GeneCards Identifiers for MYOZ3 Gene

  • GC05P150109
  • GC05P150068
  • GC05P150020
  • GC05P145186

Summaries for MYOZ3 Gene

Entrez Gene Summary for MYOZ3 Gene

  • The protein encoded by this gene is specifically expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012]

GeneCards Summary for MYOZ3 Gene

MYOZ3 (Myozenin 3) is a Protein Coding gene. An important paralog of this gene is MYOZ1.

UniProtKB/Swiss-Prot for MYOZ3 Gene

  • Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYOZ3 Gene

Genomics for MYOZ3 Gene

Regulatory Elements for MYOZ3 Gene

Genomic Location for MYOZ3 Gene

Start:
150,660,841 bp from pter
End:
150,679,368 bp from pter
Size:
18,528 bases
Orientation:
Plus strand

Genomic View for MYOZ3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYOZ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYOZ3 Gene

Proteins for MYOZ3 Gene

  • Protein details for MYOZ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDC0-MYOZ3_HUMAN
    Recommended name:
    Myozenin-3
    Protein Accession:
    Q8TDC0
    Secondary Accessions:
    • B2R9Q4
    • D3DQG9
    • Q8IVM1
    • Q8IVN1

    Protein attributes for MYOZ3 Gene

    Size:
    251 amino acids
    Molecular mass:
    27157 Da
    Quaternary structure:
    • Interacts with ACTN2, LDB3, FLNC, PPP3CA and TCAP.

    Alternative splice isoforms for MYOZ3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYOZ3 Gene

Proteomics data for MYOZ3 Gene at MOPED

Post-translational modifications for MYOZ3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYOZ3 Gene

No data available for DME Specific Peptides for MYOZ3 Gene

Domains for MYOZ3 Gene

Protein Domains for MYOZ3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYOZ3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TDC0

UniProtKB/Swiss-Prot:

MYOZ3_HUMAN :
  • Q8TDC0
Family:
  • Belongs to the myozenin family.
genes like me logo Genes that share domains with MYOZ3: view

No data available for Gene Families for MYOZ3 Gene

Function for MYOZ3 Gene

Molecular function for MYOZ3 Gene

UniProtKB/Swiss-Prot Function: Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis

Gene Ontology (GO) - Molecular Function for MYOZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10427098
genes like me logo Genes that share ontologies with MYOZ3: view

Phenotypes for MYOZ3 Gene

GenomeRNAi human phenotypes for MYOZ3:
genes like me logo Genes that share phenotypes with MYOZ3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MYOZ3 Gene

Localization for MYOZ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYOZ3 Gene

Cytoplasm, myofibril, sarcomere, Z line. Note=Localized at the Z-line of skeletal muscle. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYOZ3 Gene COMPARTMENTS Subcellular localization image for MYOZ3 gene
Compartment Confidence
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MYOZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with MYOZ3: view

Pathways for MYOZ3 Gene

SuperPathways for MYOZ3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYOZ3 Gene

None

No data available for Pathways by source for MYOZ3 Gene

Transcripts for MYOZ3 Gene

Unigene Clusters for MYOZ3 Gene

Myozenin 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYOZ3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MYOZ3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYOZ3 Gene

No ASD Table

Relevant External Links for MYOZ3 Gene

GeneLoc Exon Structure for
MYOZ3
ECgene alternative splicing isoforms for
MYOZ3

Expression for MYOZ3 Gene

mRNA expression in normal human tissues for MYOZ3 Gene

mRNA differential expression in normal tissues according to GTEx for MYOZ3 Gene

This gene is overexpressed in Muscle - Skeletal (25.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYOZ3 Gene

SOURCE GeneReport for Unigene cluster for MYOZ3 Gene Hs.91626

mRNA Expression by UniProt/SwissProt for MYOZ3 Gene

Q8TDC0-MYOZ3_HUMAN
Tissue specificity: Expressed specifically in skeletal muscle. Not detected in heart.
genes like me logo Genes that share expressions with MYOZ3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MYOZ3 Gene

Orthologs for MYOZ3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYOZ3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYOZ3 35
  • 93.2 (n)
  • 93.6 (a)
MYOZ3 36
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYOZ3 35
  • 83.54 (n)
  • 80.82 (a)
MYOZ3 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYOZ3 35
  • 87.48 (n)
  • 83.67 (a)
MYOZ3 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myoz3 35
  • 80.14 (n)
  • 75.51 (a)
Myoz3 16
Myoz3 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYOZ3 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myoz3 35
  • 80.19 (n)
  • 76.23 (a)
chicken
(Gallus gallus)
Aves MYOZ3 35
  • 57.7 (n)
  • 47.53 (a)
MYOZ3 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYOZ3 36
  • 32 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732337 35
  • 49.28 (n)
  • 42.86 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01006980.1 36
  • 37 (a)
OneToMany
myoz3a 36
  • 31 (a)
OneToMany
Species with no ortholog for MYOZ3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYOZ3 Gene

ENSEMBL:
Gene Tree for MYOZ3 (if available)
TreeFam:
Gene Tree for MYOZ3 (if available)

Paralogs for MYOZ3 Gene

Paralogs for MYOZ3 Gene

genes like me logo Genes that share paralogs with MYOZ3: view

Variants for MYOZ3 Gene

Sequence variations from dbSNP and Humsavar for MYOZ3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs194134 - 150,672,396(-) CTTGG(A/G)GATGG missense, reference
rs888715 -- 150,674,718(-) TGTTT(C/G)TTAAT intron-variant
rs2545130 -- 150,667,676(-) cctgg(C/T)tacag intron-variant
rs3832354 -- 150,671,507(-) GGGGG(-/G)AGGCA intron-variant
rs6579800 -- 150,670,166(+) ATCGA(C/G)AATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYOZ3 Gene

Variant ID Type Subtype PubMed ID
dgv1862e1 CNV Complex 17122850
nsv428129 CNV Loss 18775914
esv33898 CNV Loss 17666407
esv29484 CNV Loss 19812545

Relevant External Links for MYOZ3 Gene

HapMap Linkage Disequilibrium report
MYOZ3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYOZ3 Gene

Disorders for MYOZ3 Gene

Relevant External Links for MYOZ3

Genetic Association Database (GAD)
MYOZ3
Human Genome Epidemiology (HuGE) Navigator
MYOZ3
genes like me logo Genes that share disorders with MYOZ3: view

No data available for UniProtKB/Swiss-Prot for MYOZ3 Gene

Publications for MYOZ3 Gene

  1. Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins. (PMID: 11842093) Frey N. … Olson E.N. (J. Biol. Chem. 2002) 2 3 4 23
  2. Candidate-gene testing for orphan limb-girdle muscular dystrophies. (PMID: 19472918) Aurino S. … Nigro V. (Acta Myol 2008) 3 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for MYOZ3 Gene

Sources for MYOZ3 Gene

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