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MYOZ2 Gene

protein-coding   GIFtS: 51
GCID: GC04P120056

Myozenin 2

(Previous name: chromosome 4 open reading frame 5)
(Previous symbol: C4orf5)
  See MYOZ2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myozenin 21 2     CS-12
C4orf51 2 3     Calcineurin-Binding Protein Calsarcin-12
FATZ-Related Protein 22 3     Muscle-Specific Protein2
CMH162 5     myozenin-22
Chromosome 4 Open Reading Frame 51     Calsarcin-13

External Ids:    HGNC: 13301   Entrez Gene: 517782   Ensembl: ENSG000001723997   OMIM: 6056025   UniProtKB: Q9NPC63   

Export aliases for MYOZ2 gene to outside databases

Previous GC identifers: GC04P120814 GC04P120336 GC04P120450 GC04P120515 GC04P120414 GC04P120276 GC04P115778


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYOZ2 Gene:
The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a
phosphatase involved in calcium-dependent signal transduction in diverse cell types. These family members tether
calcineurin to alpha-actinin at the z-line of the sarcomere of cardiac and skeletal muscle cells, and thus they
are important for calcineurin signaling. Mutations in this gene cause cardiomyopathy familial hypertrophic type
16, a hereditary heart disorder. (provided by RefSeq, Aug 2011)

GeneCards Summary for MYOZ2 Gene:
MYOZ2 (myozenin 2) is a protein-coding gene. Diseases associated with MYOZ2 include cardiomyopathy, familial hypertrophic, 16, and myoz2-related familial hypertrophic cardiomyopathy. GO annotations related to this gene include actin binding and telethonin binding. An important paralog of this gene is MYOZ1.

UniProtKB/Swiss-Prot: MYOZ2_HUMAN, Q9NPC6
Function: Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as
alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere.
Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis

Gene Wiki entry for MYOZ2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MYOZ2 gene promoter:
         GCNF   SREBP-1c   MyoD   C/EBPalpha   SREBP-1b   SREBP-1a   GCNF-1   HSF2   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYOZ2 promoter sequence
   Search Chromatin IP Primers for MYOZ2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYOZ2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26-q27   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q26-q27

MYOZ2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYOZ2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P120056:  view genomic region     (about GC identifiers)

Start:
120,056,939 bp from pter      End:
120,108,944 bp from pter
Size:
52,006 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MYOZ2_HUMAN, Q9NPC6 (See protein sequence)
Recommended Name: Myozenin-2  
Size: 264 amino acids; 29898 Da
Subunit: Interacts via its C-terminus with spectrin repeats 3 and 4 of ACTN2. Interacts with ACTN1, LDB3, MYOT and
PPP3CA
Secondary accessions: O43415 Q9HB92

Explore the universe of human proteins at neXtProt for MYOZ2: NX_Q9NPC6

Explore proteomics data for MYOZ2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYOZ2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057683.1  
    ENSEMBL proteins: 
     ENSP00000306997  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008438 MYOZ

    Graphical View of Domain Structure for InterPro Entry Q9NPC6

    ProtoNet protein and cluster: Q9NPC6

    UniProtKB/Swiss-Prot: MYOZ2_HUMAN, Q9NPC6
    Similarity: Belongs to the myozenin family


    Find genes that share domains with MYOZ2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYOZ2_HUMAN, Q9NPC6
    Function: Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as
    alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere.
    Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI10427098
    GO:0030346protein phosphatase 2B binding NAS11114196
    GO:0031433telethonin binding IPI15582318
         
    Find genes that share ontologies with MYOZ2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MYOZ2:
     Increased cell death HMECs cel 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Myoz2):
     cardiovascular system  homeostasis/metabolism  mortality/aging  muscle 

    Find genes that share phenotypes with MYOZ2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYOZ2
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    8 qRT-PCR Assays for microRNAs that regulate MYOZ2:
    hsa-miR-3671 hsa-miR-203 hsa-miR-607 hsa-miR-3200-5p hsa-miR-3120-3p hsa-miR-570 hsa-miR-942 hsa-miR-3119
    SwitchGear 3'UTR luciferase reporter plasmidMYOZ2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MYOZ2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MYOZ2 (NM_016599)
    Sino Biological Human cDNA Clone for MYOZ2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYOZ2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOZ2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYOZ2_HUMAN, Q9NPC6: Cytoplasm, myofibril, sarcomere, Z line (By similarity). Note=Colocalizes with ACTN1 and
    PPP3CA at the Z-line of heart and skeletal muscle (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    cytosol2
    nucleus2
    golgi apparatus1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015629actin cytoskeleton IEA--
    GO:0030017sarcomere TAS11114196
    GO:0030018Z disc NAS15582318

    Find genes that share ontologies with MYOZ2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYOZ2
    Interactions:

        GeneGlobe Interaction Network for MYOZ2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for MYOZ2 (Q9NPC61, 2, 3 ENSP000003069974) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTN4O437072, 3, ENSP000002526994MINT-67265 I2D: score=5 STRING: ENSP00000252699
    TCAPO152731, 3, ENSP000003126244EBI-746712,EBI-954089 I2D: score=1 STRING: ENSP00000312624
    LDB3O751123, ENSP000003552964I2D: score=3 STRING: ENSP00000355296
    PPP3CAQ082093, ENSP000003783234I2D: score=3 STRING: ENSP00000378323
    ACTN2P356093, ENSP000003555374I2D: score=1 STRING: ENSP00000355537
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with MYOZ2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYOZ2

    4 Novoseek inferred chemical compound relationships for MYOZ2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 37.4 6 2039488 (1), 1690725 (1), 1985013 (1), 16378590 (1) (see all 6)
    calcium 14.8 2 7805577 (1), 11842093 (1)
    acetylcholine 13.5 2 8241960 (1), 8844403 (1)
    tyrosine 0 1 16785025 (1)



    Find genes that share compounds with MYOZ2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYOZ2 gene: 
    NM_016599.4  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000307128(uc003icp.4)
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate MYOZ2:
    hsa-miR-3671 hsa-miR-203 hsa-miR-607 hsa-miR-3200-5p hsa-miR-3120-3p hsa-miR-570 hsa-miR-942 hsa-miR-3119
    SwitchGear 3'UTR luciferase reporter plasmidMYOZ2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MYOZ2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYOZ2
    Primer
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    OriGene qPCR primer pairs and template standards for MYOZ2
    OriGene qSTAR qPCR primer pairs in human, mouse for MYOZ2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYOZ2
      QuantiTect SYBR Green Assays in human, mouse, rat MYOZ2
      QuantiFast Probe-based Assays in human, mouse, rat MYOZ2

    Selected AceView cDNA sequences (see all 160):

    BC020932 BC017402 CB856425 W68833 AJ709903 BC005195 BX110822 AA234076 
    AA447845 AI187095 AI191397 AL600539 BM677454 F26388 AJ252149 BF694815 
    AL601108 CB995353 C05519 D58154 W95959 Z25905 AL600945 BF790335 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYOZ2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MYOZ2 Expression
    About this image


    MYOZ2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Heart (Cardiovascular System)
             Cardiomyocyte-like progenitor cells
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
    MYOZ2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYOZ2 Protein Expression

    UniProtKB/Swiss-Prot: MYOZ2_HUMAN, Q9NPC6
    Tissue specificity: Expressed specifically in heart and skeletal muscle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MYOZ2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myoz21 , 5 myozenin 21, 5 87.12(n)1
    88.26(a)1
      3 (53.78 cM)5
    590061  NM_021503.21  NP_067478.11 
     1230062065 
    chicken
    (Gallus gallus)
    Aves MYOZ21 myozenin 2 74.9(n)
    71.86(a)
      422682  NM_001277827.1  NP_001264756.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYOZ26
    myozenin 2
    72(a)
    1 ↔ 1
    5(140095278-140128645)
    African clawed frog
    (Xenopus laevis)
    Amphibia myoz2-prov2 myozenin 2 77.66(n)    BC042308.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc777032 hypothetical protein MGC77703 77.41(n)   393828  BC062840.1 


    ENSEMBL Gene Tree for MYOZ2 (if available)
    TreeFam Gene Tree for MYOZ2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYOZ2 gene
    MYOZ12  MYOZ32  

    Find genes that share paralogs with MYOZ2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYOZ2 (see all 1095)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1401266781,2,,4
    C,FCardiomyopathy, familial hypertrophic 16 (CMH16)4 pathogenic1119900701(+) CCTATA/GGTGAT 2 I M mis11Minor allele frequency- G:0.00NA 4550
    VAR_0654694
    Cardiomyopathy, familial hypertrophic 16 (CMH16)4--see VAR_0654692 S P mis40--------
    rs115590581,2
    C,Funtested1119850458(+) CATCCA/GTAGTC 1 -- ut51 ese31Minor allele frequency- G:0.03NA 120
    rs178515241,2
    C,Funtested1119865588(+) AGAGCA/G/TCAAAT 2 A syn14CSA NA EU 5974
    rs117215661,2
    C,F,A,Huntested1119872560(+) AGTTTG/ACTTTT 1 -- int125Minor allele frequency- A:0.43NS EA NA WA CSA EU 3675
    rs76876131,2
    C,F,Huntested1119878852(+) TGGGAA/GCAAGC 2 E syn123Minor allele frequency- G:0.08NS EA NA WA CSA EU 8207
    rs2015889481,2
    --115795065(+) AACTA-/TAGTAT 1 -- int10--------
    rs44105121,2
    C,F,H--119848402(+) ATAACC/TGATTT 1 -- us2k115Minor allele frequency- T:0.06NS EA NA WA 2056
    rs1458333291,2
    --119848403(+) TAACCA/GATTTC 1 -- us2k10--------
    rs729085991,2
    C,F--119848627(+) TAGGAT/CTCATA 1 -- us2k12Minor allele frequency- C:0.13WA 120

    HapMap Linkage Disequilibrium report for MYOZ2 (120056939 - 120108944 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MYOZ2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv271047CNV Insertion20981092
    nsv507191CNV Insertion20534489
    nsv4488CNV Insertion18451855
    nsv522386CNV Gain19592680

    Human Gene Mutation Database (HGMD): MYOZ2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYOZ2
    DNA2.0 Custom Variant and Variant Library Synthesis for MYOZ2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605602   
    OMIM disorders: 613838  
    UniProtKB/Swiss-Prot: MYOZ2_HUMAN, Q9NPC6
  • Cardiomyopathy, familial hypertrophic 16 (CMH16) [MIM:613838]: A hereditary heart disorder characterized
    by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The
    symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by
    exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high
    risk of cardiac failure and sudden cardiac death. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 2 diseases for MYOZ2:    
    About MalaCards
    cardiomyopathy, familial hypertrophic, 16    myoz2-related familial hypertrophic cardiomyopathy

    1 disease from the University of Copenhagen DISEASES database for MYOZ2:
    Hypertrophic cardiomyopathy

    Find genes that share disorders with MYOZ2           About GenesLikeMe

    10 Novoseek inferred disease relationships for MYOZ2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    muscle necrosis 47.7 1 2388283 (1)
    myopathy 47.2 3 19047374 (1), 18628314 (1), 7981588 (1)
    rhabdomyosarcoma 42.5 1 9581851 (1)
    adenoma pleomorphic 39.4 2 10458827 (1), 1661898 (1)
    muscular dystrophy duchenne 38.7 1 7508114 (1)
    cardiac hypertrophy 27.8 2 12965203 (1), 11842093 (1)
    cardiomyopathy 24.8 1 15543153 (1)
    hypertrophy 16.1 2 16293906 (1), 15543153 (1)
    atrophy 5.41 1 16931880 (1)
    tumors 0 2 18022385 (1), 9581851 (1)

    Genetic Association Database (GAD): MYOZ2
    Human Genome Epidemiology (HuGE) Navigator: MYOZ2 (4 documents)

    Export disorders for MYOZ2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYOZ2 gene, integrated from 10 sources (see all 127):
    (articles sorted by number of sources associating them with MYOZ2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy. (PubMed id 17347475)1, 2, 4, 9 Osio A.... Marian A.J. (Circ. Res. 2007)
    2. Sequence analysis of myozenin 2 in 438 European patients with familial hypertrophic cardiomyopathy. (PubMed id 18591919)1, 4, 9 Posch M.G....Ozcelik C. (Med. Sci. Monit. 2008)
    3. The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins. (PubMed id 16076904)1, 2, 9 Gontier Y.... Borradori L. (J. Cell Sci. 2005)
    4. Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. (PubMed id 11114196)1, 2, 9 Frey N.... Olson E.N. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    5. Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins. (PubMed id 11842093)1, 2, 9 Frey N. and Olson E.N. (J. Biol. Chem. 2002)
    6. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    7. Candidate-gene testing for orphan limb-girdle muscular dystrophies. (PubMed id 19472918)1, 4 Aurino S....Nigro V. (Acta Myol 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Identification and characterization of a novel gene (C4orf5) located on human chromosome 4q with specific expression in cardiac and skeletal muscle. (PubMed id 11161785)1, 2 Ahmad F.... Roberts R. (Genomics 2000)
    10. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (Genome Res. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51778 HGNC: 1330 AceView: MYOZ2 Ensembl:ENSG00000172399 euGenes: HUgn51778
    ECgene: MYOZ2 H-InvDB: MYOZ2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYOZ2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYOZ2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYOZ2 gene:
    Search GeneIP for patents involving MYOZ2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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