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Aliases for MYOM3 Gene

Aliases for MYOM3 Gene

  • Myomesin 3 2 3
  • Myomesin Family, Member 3 2 3
  • Myomesin Family Member 3 4
  • Myomesin-3 3

External Ids for MYOM3 Gene

Previous GeneCards Identifiers for MYOM3 Gene

  • GC00U916990
  • GC01M024127
  • GC01M024255
  • GC01M024383
  • GC01M022635

Summaries for MYOM3 Gene

GeneCards Summary for MYOM3 Gene

MYOM3 (Myomesin 3) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is MYBPC2.

UniProtKB/Swiss-Prot for MYOM3 Gene

  • May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYOM3 Gene

Genomics for MYOM3 Gene

Regulatory Elements for MYOM3 Gene

Genomic Location for MYOM3 Gene

24,056,035 bp from pter
24,112,175 bp from pter
56,141 bases
Minus strand

Genomic View for MYOM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYOM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYOM3 Gene

Proteins for MYOM3 Gene

  • Protein details for MYOM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NF75
    • Q5VTT6
    • Q6AWC0
    • Q6AWC1
    • Q6NXF9
    • Q6ZRG7
    • Q7Z3G9
    • Q8NA11
    • Q96C54

    Protein attributes for MYOM3 Gene

    1437 amino acids
    Molecular mass:
    162189 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for MYOM3 Gene


neXtProt entry for MYOM3 Gene

Proteomics data for MYOM3 Gene at MOPED

Post-translational modifications for MYOM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYOM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYOM3 Gene

Domains for MYOM3 Gene

Gene Families for MYOM3 Gene

  • FN3 :Fibronectin type III domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing

Suggested Antigen Peptide Sequences for MYOM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5VTT5
  • Contains 5 fibronectin type-III domains.
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with MYOM3: view

Function for MYOM3 Gene

Molecular function for MYOM3 Gene

UniProtKB/Swiss-Prot Function:
May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle.

Gene Ontology (GO) - Molecular Function for MYOM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042803 protein homodimerization activity ISS --
genes like me logo Genes that share ontologies with MYOM3: view

Phenotypes for MYOM3 Gene

GenomeRNAi human phenotypes for MYOM3:
genes like me logo Genes that share phenotypes with MYOM3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYOM3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MYOM3 Gene

Localization for MYOM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYOM3 Gene

Cytoplasm, myofibril, sarcomere, M line.

Subcellular locations from

Jensen Localization Image for MYOM3 Gene COMPARTMENTS Subcellular localization image for MYOM3 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for MYOM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031430 M band ISS --
genes like me logo Genes that share ontologies with MYOM3: view

Pathways for MYOM3 Gene

SuperPathways for MYOM3 Gene

No Data Available

Interacting Proteins for MYOM3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000363557 for MYOM3 Gene via STRING

Gene Ontology (GO) - Biological Process for MYOM3 Gene


No data available for Pathways by source for MYOM3 Gene

Transcripts for MYOM3 Gene

Unigene Clusters for MYOM3 Gene

Myomesin 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYOM3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYOM3 Gene

No ASD Table

Relevant External Links for MYOM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYOM3 Gene

mRNA expression in normal human tissues for MYOM3 Gene

mRNA differential expression in normal tissues according to GTEx for MYOM3 Gene

This gene is overexpressed in Muscle - Skeletal (23.2), Heart - Left Ventricle (17.1), and Heart - Atrial Appendage (8.7).

Protein differential expression in normal tissues for MYOM3 Gene

This gene is overexpressed in Heart (64.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYOM3 Gene

SOURCE GeneReport for Unigene cluster for MYOM3 Gene Hs.523413

genes like me logo Genes that share expressions with MYOM3: view

Expression partners for MYOM3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MYOM3 Gene

Orthologs for MYOM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYOM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MYOM3 35
  • 86.01 (n)
  • 85.7 (a)
MYOM3 36
  • 85 (a)
(Canis familiaris)
Mammalia MYOM3 35
  • 87.48 (n)
  • 87.74 (a)
MYOM3 36
  • 87 (a)
(Mus musculus)
Mammalia Myom3 35
  • 83.37 (n)
  • 83.34 (a)
Myom3 16
Myom3 36
  • 83 (a)
(Pan troglodytes)
Mammalia MYOM3 35
  • 98.93 (n)
  • 98.61 (a)
MYOM3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Myom3 35
  • 82.83 (n)
  • 83.69 (a)
(Monodelphis domestica)
Mammalia MYOM3 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia MYOM3 36
  • 61 (a)
(Gallus gallus)
Aves MYOM3 35
  • 63.47 (n)
  • 60.84 (a)
MYOM3 36
  • 60 (a)
(Anolis carolinensis)
Reptilia MYOM3 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia myom3 35
  • 58.08 (n)
  • 54.45 (a)
(Danio rerio)
Actinopterygii myom3 35
  • 54.3 (n)
  • 43.8 (a)
myom3 36
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14964 36
  • 11 (a)
sls 36
  • 2 (a)
Species with no ortholog for MYOM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYOM3 Gene

Gene Tree for MYOM3 (if available)
Gene Tree for MYOM3 (if available)

Paralogs for MYOM3 Gene

Paralogs for MYOM3 Gene

Selected SIMAP similar genes for MYOM3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MYOM3: view

Variants for MYOM3 Gene

Sequence variations from dbSNP and Humsavar for MYOM3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3795303 -- 24,062,189(-) AAACC(A/G)GAGGA intron-variant
rs3885698 -- 24,097,751(+) TGCTG(C/T)GAAGG intron-variant
rs3923546 -- 24,087,587(+) tcttc(C/T)ccgag intron-variant
rs3934861 -- 24,105,466(-) GATGA(C/T)GGTGA intron-variant
rs4073373 -- 24,093,558(-) TGACC(C/T)CACGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYOM3 Gene

Variant ID Type Subtype PubMed ID
esv2609872 CNV Deletion 19546169
esv1968924 CNV Deletion 18987734
esv2745430 CNV Deletion 23290073
esv989974 CNV Deletion 20482838
esv1250620 CNV Deletion 17803354
esv5851 CNV Loss 19470904
nsv822054 CNV Loss 20364138

Relevant External Links for MYOM3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYOM3 Gene

Disorders for MYOM3 Gene

Relevant External Links for MYOM3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MYOM3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MYOM3 Gene

Publications for MYOM3 Gene

  1. Myomesin 3, a novel structural component of the M-band in striated muscle. (PMID: 18177667) Schoenauer R. … Agarkova I. (J. Mol. Biol. 2008) 2 3 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 48
  4. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 48
  5. Genome-wide association of mood-incongruent psychotic bipolar disorder. (PMID: 23092984) Goes F.S. … Potash J.B. (Transl Psychiatry 2012) 3

Products for MYOM3 Gene

Sources for MYOM3 Gene

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