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Aliases for MYOM3 Gene

Aliases for MYOM3 Gene

  • Myomesin 3 2 3 5
  • Myomesin Family, Member 3 2 3
  • Myomesin Family Member 3 4
  • Myomesin-3 3

External Ids for MYOM3 Gene

Previous GeneCards Identifiers for MYOM3 Gene

  • GC00U916990
  • GC01M024127
  • GC01M024255
  • GC01M024383
  • GC01M022635

Summaries for MYOM3 Gene

GeneCards Summary for MYOM3 Gene

MYOM3 (Myomesin 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is MYOM2.

UniProtKB/Swiss-Prot for MYOM3 Gene

  • May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle.

Additional gene information for MYOM3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYOM3 Gene

Genomics for MYOM3 Gene

GeneHancer (GH) Regulatory Elements for MYOM3 Gene

Promoters and enhancers for MYOM3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I024091 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 573.3 +9.7 9653 21.4 PKNOX1 SMAD1 FOXA2 ARID4B DMAP1 ZNF2 SLC30A9 FOS ZNF263 SP5 MYOM3 SRRM1 LINC01355 SRSF10 ELOA IL22RA1 LOC105376864
GH01I024014 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +92.8 92806 9.3 PKNOX1 SMAD1 FOXA2 MLX ZFP64 ARID4B NEUROD1 FEZF1 DMAP1 ZNF2 SRSF10 LINC01355 SRRM1 HNRNPR PNRC2 CNR2 ENSG00000230703 MYOM3 LOC105376863 ENSG00000225315
GH01I024115 Enhancer 1.3 Ensembl ENCODE dbSUPER 14.9 -6.9 -6942 6.2 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF121 GLIS2 FOS RXRA SP5 MYOM3 IL22RA1 LOC105376871 GRHL3 NCMAP IFNLR1 PNRC2 GC01P024142
GH01I024149 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.2 -39.2 -39200 3.8 ATF1 ARID4B ZNF143 FOS SP3 RXRA YY2 NFYC REST SMARCA4 IFNLR1 GRHL3 MYOM3 LOC105376871 NCMAP IL22RA1 PNRC2 GC01P024177
GH01I024079 Enhancer 0.5 dbSUPER 18.1 +30.9 30945 3.6 RXRA MAX ZFP36 ZMYM3 HNF4A MYOM3 LOC105376871 GRHL3 PNRC2 ENSG00000230703 LOC105376864 ENSG00000225315
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MYOM3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MYOM3 gene promoter:

Genomic Locations for MYOM3 Gene

Genomic Locations for MYOM3 Gene
chr1:24,056,035-24,112,175
(GRCh38/hg38)
Size:
56,141 bases
Orientation:
Minus strand
chr1:24,382,525-24,438,665
(GRCh37/hg19)

Genomic View for MYOM3 Gene

Genes around MYOM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYOM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYOM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYOM3 Gene

Proteins for MYOM3 Gene

  • Protein details for MYOM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VTT5-MYOM3_HUMAN
    Recommended name:
    Myomesin-3
    Protein Accession:
    Q5VTT5
    Secondary Accessions:
    • A6NF75
    • Q5VTT6
    • Q6AWC0
    • Q6AWC1
    • Q6NXF9
    • Q6ZRG7
    • Q7Z3G9
    • Q8NA11
    • Q96C54

    Protein attributes for MYOM3 Gene

    Size:
    1437 amino acids
    Molecular mass:
    162189 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for MYOM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYOM3 Gene

Post-translational modifications for MYOM3 Gene

No Post-translational modifications

Other Protein References for MYOM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYOM3 Gene

Domains & Families for MYOM3 Gene

Suggested Antigen Peptide Sequences for MYOM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYOM3: view

No data available for UniProtKB/Swiss-Prot for MYOM3 Gene

Function for MYOM3 Gene

Molecular function for MYOM3 Gene

UniProtKB/Swiss-Prot Function:
May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle.

Phenotypes From GWAS Catalog for MYOM3 Gene

Gene Ontology (GO) - Molecular Function for MYOM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008307 structural constituent of muscle IBA --
GO:0042803 protein homodimerization activity IEA,ISS --
GO:0051015 actin filament binding IBA --
GO:0051371 muscle alpha-actinin binding IBA --
GO:0097493 structural molecule activity conferring elasticity IBA --
genes like me logo Genes that share ontologies with MYOM3: view
genes like me logo Genes that share phenotypes with MYOM3: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYOM3 Gene

Localization for MYOM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYOM3 Gene

Cytoplasm, myofibril, sarcomere, M line.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYOM3 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYOM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005859 muscle myosin complex IBA --
GO:0030018 Z disc IBA --
GO:0031430 M band ISS --
genes like me logo Genes that share ontologies with MYOM3: view

Pathways & Interactions for MYOM3 Gene

SuperPathways for MYOM3 Gene

No Data Available

Interacting Proteins for MYOM3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000363557%0d%0a9606.ENSP00000363390%0d%0a9606.ENSP00000386881%0d%0a
Selected Interacting proteins: ENSP00000363557 Q5VTT5-MYOM3_HUMAN for MYOM3 Gene via STRING IID UniProtKB

Gene Ontology (GO) - Biological Process for MYOM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006941 striated muscle contraction IBA --
GO:0007015 actin filament organization IBA --
GO:0045214 sarcomere organization IBA --
GO:0071688 striated muscle myosin thick filament assembly IBA --
genes like me logo Genes that share ontologies with MYOM3: view

No data available for Pathways by source and SIGNOR curated interactions for MYOM3 Gene

Drugs & Compounds for MYOM3 Gene

No Compound Related Data Available

Transcripts for MYOM3 Gene

Unigene Clusters for MYOM3 Gene

Myomesin 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYOM3 Gene

No ASD Table

Relevant External Links for MYOM3 Gene

GeneLoc Exon Structure for
MYOM3
ECgene alternative splicing isoforms for
MYOM3

Expression for MYOM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYOM3 Gene

mRNA differential expression in normal tissues according to GTEx for MYOM3 Gene

This gene is overexpressed in Muscle - Skeletal (x23.2), Heart - Left Ventricle (x17.1), and Heart - Atrial Appendage (x8.7).

Protein differential expression in normal tissues from HIPED for MYOM3 Gene

This gene is overexpressed in Heart (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYOM3 Gene



Protein tissue co-expression partners for MYOM3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MYOM3 Gene:

MYOM3

SOURCE GeneReport for Unigene cluster for MYOM3 Gene:

Hs.523413

Evidence on tissue expression from TISSUES for MYOM3 Gene

  • Muscle(4.6)
  • Intestine(4.2)
  • Nervous system(4.1)
  • Heart(3.5)
genes like me logo Genes that share expression patterns with MYOM3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYOM3 Gene

Orthologs for MYOM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYOM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYOM3 33 34
  • 98.93 (n)
dog
(Canis familiaris)
Mammalia MYOM3 33 34
  • 87.48 (n)
cow
(Bos Taurus)
Mammalia MYOM3 33 34
  • 86.01 (n)
mouse
(Mus musculus)
Mammalia Myom3 33 16 34
  • 83.37 (n)
rat
(Rattus norvegicus)
Mammalia Myom3 33
  • 82.83 (n)
oppossum
(Monodelphis domestica)
Mammalia MYOM3 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYOM3 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYOM3 33 34
  • 63.47 (n)
lizard
(Anolis carolinensis)
Reptilia MYOM3 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myom3 33
  • 58.08 (n)
zebrafish
(Danio rerio)
Actinopterygii myom3 33 34
  • 54.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14964 34
  • 11 (a)
ManyToMany
sls 34
  • 2 (a)
ManyToMany
Species where no ortholog for MYOM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYOM3 Gene

ENSEMBL:
Gene Tree for MYOM3 (if available)
TreeFam:
Gene Tree for MYOM3 (if available)

Paralogs for MYOM3 Gene

Paralogs for MYOM3 Gene

(3) SIMAP similar genes for MYOM3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MYOM3: view

Variants for MYOM3 Gene

Sequence variations from dbSNP and Humsavar for MYOM3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000022567 -- 24,113,097(-) G/A upstream_transcript_variant
rs1000031554 -- 24,100,729(-) A/G intron_variant
rs1000120884 -- 24,103,222(-) C/T intron_variant
rs1000215079 -- 24,100,909(-) A/G intron_variant
rs1000272353 -- 24,110,523(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MYOM3 Gene

Variant ID Type Subtype PubMed ID
dgv61n106 CNV deletion 24896259
esv1250620 CNV deletion 17803354
esv1968924 CNV deletion 18987734
esv2609872 CNV deletion 19546169
esv2745430 CNV deletion 23290073
esv2853014 CNV deletion 24192839
esv3558788 CNV deletion 23714750
esv5851 CNV loss 19470904
esv989974 CNV deletion 20482838
nsv472633 CNV novel sequence insertion 20440878
nsv475436 CNV novel sequence insertion 20440878
nsv822054 CNV loss 20364138

Variation tolerance for MYOM3 Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 26.68; 99.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYOM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYOM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYOM3 Gene

Disorders for MYOM3 Gene

Additional Disease Information for MYOM3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MYOM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYOM3 Gene

Publications for MYOM3 Gene

  1. Myomesin 3, a novel structural component of the M-band in striated muscle. (PMID: 18177667) Schoenauer R … Agarkova I (Journal of molecular biology 2008) 2 3 22 58
  2. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 44 58
  3. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Serum proteomic profiling reveals fragments of MYOM3 as potential biomarkers for monitoring the outcome of therapeutic interventions in muscular dystrophies. (PMID: 26060189) Rouillon J … Svinartchouk F (Human molecular genetics 2015) 3 58

Products for MYOM3 Gene

Sources for MYOM3 Gene

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