MYOM3 Gene
protein-coding GIFtS: 45
GCID: GC01M024383
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|
myomesin 3(Previous names: myomesin family, member 3 )
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Aliases
for MYOM3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Myomesin 31 2 | | Myomesin Family, Member 31 2 | | FLJ359611 | | RP11-293P20.12 | | Myomesin-31 | | Myomesin Family Member 33 |
| External Ids: | HGNC: 266791 | Entrez Gene: 1272942 | Ensembl: ENSG000001426617 | UniProtKB: Q5VTT53 | | ORGUL members: | |
|---|
| NONCODE:n337774 | |
Export aliases for MYOM3 gene to outside databasesPrevious GC identifers: GC00U916990 GC01M024127 GC01M024255 GC01M022635
|---|
Summaries
for MYOM3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MYOM3_HUMAN, Q5VTT5Function: May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle (Bysimilarity)
|
Genomic Views
for MYOM3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MYOM3 gene promoter:
Max1 NF-1 Pax-5 FOXJ2 (long isoform) FOXO1a MyoD FOXJ2 TGIF Pax-4a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MYOM3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYOM3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.11 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36MYOM3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M024383: view genomic region
(about GC identifiers)
Start:
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24,382,525 bp from pter |
End:
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24,438,665 bp from pter |
Size:
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56,141 bases |
Orientation:
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minus strand |
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Proteins
for MYOM3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MYOM3_HUMAN, Q5VTT5 (See
protein sequence)Recommended Name: Myomesin-3 Size: 1437 amino acids; 162189 Da
Subunit: Homodimer (By similarity)
Subcellular location: Cytoplasm, myofibril, sarcomere, M line (By similarity)
Secondary accessions: A6NF75 Q5VTT6 Q6AWC0 Q6AWC1 Q6NXF9 Q6ZRG7 Q7Z3G9 Q8NA11 Q96C54Alternative splicing: 3 isoforms: Q5VTT5-1 Q5VTT5-2 Q5VTT5-3 Explore the universe of human proteins at neXtProt for MYOM3: NX_Q5VTT5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VTT5
MYOM3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689585.3
ENSEMBL proteins: ENSP00000342689 ENSP00000363557 ENSP00000332670 ENSP00000328415
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031430 | M band |
ISS | -- |
MYOM3 for ontologies About GeneDecksing
MYOM3 Antibody Products:
Assay Products for MYOM3: |
Protein
Domains /
Families
for MYOM3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MYOM3 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q5VTT5ProtoNet protein and cluster: Q5VTT5 3 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB003962 Fibronectin type III repeat signature IPB013098 Immunoglobulin I-set
UniProtKB/Swiss-Prot: MYOM3_HUMAN, Q5VTT5Similarity: Contains 5 fibronectin type-III domainsSimilarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains |
Function
for MYOM3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MYOM3_HUMAN, Q5VTT5Function: May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle (Bysimilarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYOM3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYOM3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MYOM3 (NM_152372) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYOM3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYOM3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOM3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042803 | protein homodimerization activity |
ISS | -- |
MYOM3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MYOM3:
|
Pathways & Interactions
for MYOM3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYOM3
|
Drugs & Compounds
for MYOM3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MYOM3
Search CenterWatch for drugs/clinical trials and news about MYOM3
|
Transcripts
for MYOM3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MYOM3 gene: NM_152372.3 Unigene Cluster for MYOM3: Myomesin 3 Hs.523413 [show with all ESTs]Unigene Representative Sequence: NM_1523725 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000338909(uc001bil.4) ENST00000374434(uc001bim.4 uc001bin.4)
ENST00000475306(uc001bip.1) ENST00000330966 ENST00000329601(uc001bio.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYOM3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYOM3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MYOM3 (NM_152372) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYOM3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYOM3 |
Additional cDNA sequence: AF086254.1 AK093280.1 AK125972.1 AK128233.1 BC014671.1 BC067101.1 BX537911.1 BX647453.1 BX647455.1 BX647644.1 5 DOTS entries: DT.97801081 DT.40297209 DT.99952758 DT.101976375 DT.95346000 24/59 AceView cDNA sequences (see all 59): CF552719 AW299472 BX647453 BF108688 BC067101 W67304 AI741343 BX647644 BX537911 AK125972 AI825690 AI080235 AF086254 AI190111 AW299419 AI762005 AJ574468 AI627344 AI266217 BX089444 AK093280 BX951749 AW138446 AX748029
GeneLoc Exon Structure
|
Expression
for MYOM3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MYOM3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MYOM3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYOM3
SOURCE GeneReport for Unigene cluster: Hs.523413
SABiosciences Custom PCR Arrays for MYOM3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYOM3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYOM3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYOM3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYOM3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOM3 |
Orthologs
for MYOM3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MYOM3 gene from 4/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MYOM31 |
myomesin family, member 3 |
63.79(n)
61.57(a) |
|
419690 XM_417838.3 XP_417838.3 |
lizard
(Anolis carolinensis) |
Reptilia |
MYOM36 |
-- |
59(a) |
1 ↔ 1 |
GL343498.1(2157-34425) |
zebrafish
(Danio rerio) |
Actinopterygii |
CR293507.26 |
-- |
44(a) |
1 ↔ 1 |
16(56019755-56113767) |
worm
(Caenorhabditis elegans) |
Secernentea |
ttn-16 |
TiTiN family member (ttn-1) |
1(a) |
1 → many |
V(6120892-6202609) |
ENSEMBL Gene Tree for MYOM3 (if available)
TreeFam Gene Tree for MYOM3 (if available) |
Paralogs
for MYOM3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MYOM3 gene
- MYOM12 MYBPH2 IGSF222 IGFN12 MYBPC22 MYBPC12 MYBPC32 MYBPHL2
- MYOM22
3 SIMAP similar genes for MYOM3 using alignment to 3 protein entries: MYOM3_HUMAN (see all proteins):MYOM2 MYOM1 MUSK
MYOM3 for paralogs About GeneDecksing
|
Genomic Variants
for MYOM3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MYOM3 (24382525 - 24438665 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for MYOM3
1 CNV: 97319
4 Indels: 24126 44543 39591 60807 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYOM3 |
|
Disorders
/ Diseases
for MYOM3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MYOM3 for disorders About MalaCards
MYOM3 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: MYOM3 (2 documents)
Export disorders for MYOM3 gene to outside databases
|
Publications
for MYOM3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MYOM3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MYOM3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Myomesin 3, a novel structural component of the M-band in striated muscle. (PubMed id 18177667)1, 3, 9 Schoenauer R....Agarkova I. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1 Luke M.M....Psaty B.M. (2009)
- Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1 Shiffman D....Psaty B.M. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for MYOM3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MYOM3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MYOM3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MYOM3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MYOM3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MYOM3 gene:
Search GeneIP for patents involving MYOM3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MYOM3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MYOM3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYOM3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYOM3 | | | OriGene Protein Over-expression Lysate for MYOM3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MYOM3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYOM3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYOM3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MYOM3 | | OriGene Custom Protein Services for MYOM3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MYOM3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYOM3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYOM3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYOM3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYOM3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYOM3 |
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 |  |  |  | |
| | | | Search Tocris compounds for MYOM3 |
| |  |  |  |  | | | | |
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 | | | MYOM3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOM3 |
|  |  |  | | | | Search ThermoFisher Antibodies for MYOM3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYOM3 |
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