Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

MYOM1 Gene

protein-coding GIFtS: 57
GCID: GC18M003056

Myomesin 1

(Previous names: myomesin 1 (skelemin) (185kD), myomesin 1 (skelemin) 185kDa,...)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Myomesin 1¹ ²		SKELEMIN² ⁵
Myomesin 1 (Skelemin) 185kDa¹ ²		Myomesin 1 (Skelemin) (185kD)¹
Myomesin 1, 185kDa¹ ²		skelemin¹
Myomesin Family Member 1² ³		EH-myomesin²
190 KDa Connectin-Associated Protein² ³		Myomesin (M-Protein) 1 (190kD)²
190 KDa Titin-Associated Protein² ³		myomesin-1²

External Ids:	HGNC: 7613¹	Entrez Gene: 8736²	Ensembl: ENSG00000101605⁷	OMIM: 603508⁵	UniProtKB: P52179³

Export aliases for MYOM1 gene to outside databases

Previous GC identifers: GC18M003315 GC18M003054

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MYOM1 Gene:

The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres,

the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly

to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein,

myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong

homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and

myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement

II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region.

The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M

band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of

immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been

identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for MYOM1 Gene:

MYOM1 (myomesin 1) is a protein-coding gene. Diseases associated with MYOM1 include myopia-2, and blepharospasm. GO annotations related to this gene include structural constituent of muscle and protein homodimerization activity. An important paralog of this gene is IGSF22.

UniProtKB/Swiss-Prot: MYOM1_HUMAN, P52179

Function: Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This

binding is dose dependent

Gene Wiki entry for MYOM1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence:

NC_000018.10 NC_018929.2 NT_010859.15

Regulatory elements:

Regulatory transcription factor binding sites in the MYOM1 gene promoter:
Max1 AML1a p300 Lmo2 GATA-1 C/EBPalpha YY1 Evi-1 FOXO4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYOM1 promoter sequence

Search Chromatin IP Primers for MYOM1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYOM1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.31 Ensembl cytogenetic band: 18p11.31 HGNC cytogenetic band: 18p11.31

MYOM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYOM1 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M003056: view genomic region (about GC identifiers)

Start:	3,066,805 bp from pter	End:	3,220,106 bp from pter
Size:	153,302 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MYOM1_HUMAN, P52179 (See protein sequence)

Recommended Name: Myomesin-1

Size: 1685 amino acids; 187627 Da

Subunit: Homodimer (By similarity). Interacts with TTN/titin (By similarity). Interacts with PNKD

Sequence caution: Sequence=CAA48833.1; Type=Erroneous initiation;

4 PDB 3D structures from and Proteopedia for MYOM1:

2R15 (3D)

2Y23 (3D)

2Y25 (3D)

3RBS (3D)

Secondary accessions: Q14BD6 Q6H969 Q6ZUU0

Alternative splicing: 2 isoforms: P52179-1 P52179-2

Explore the universe of human proteins at neXtProt for MYOM1: NX_P52179

Explore proteomics data for MYOM1 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See MYOM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_003794.3 NP_062830.1

ENSEMBL proteins:

ENSP00000348821 ENSP00000261606 ENSP00000462039 ENSP00000383413

MYOM1 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom MassSpec OriGene Custom Protein Services for MYOM1
	GenScript Custom Purified and Recombinant Proteins Services for MYOM1
	Novus Biologicals MYOM1 Protein
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for MYOM1

MYOM1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MYOM1
	Browse R&D Systems for Antibodies
	OriGene Antibodies for MYOM1 OriGene Custom Antibody Services for MYOM1
	Novus Biologicals MYOM1 Antibodies
	Abcam antibodies for MYOM1
	Cloud-Clone Corp. Antibodies for MYOM1
	Search ThermoFisher Antibodies for MYOM1
	LSBio Antibodies in human, mouse, rat for MYOM1

MYOM1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for MYOM1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MYOM1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for MYOM1 Cloud-Clone Corp. CLIAs for MYOM1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

HGNC Gene Families:

FN3: Fibronectin type III domain containing

ISET: Immunoglobulin superfamily / I-set domain containing

Selected InterPro protein domains (see all 6):

IPR003598 Ig_sub2

IPR003961 Fibronectin_type3

IPR013098 Ig_I-set

IPR013783 Ig-like_fold

IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry P52179

ProtoNet protein and cluster: P52179

2 Blocks protein domains:

IPB003598 Immunoglobulin C-2 type

IPB003962 Fibronectin type III repeat signature

UniProtKB/Swiss-Prot: MYOM1_HUMAN, P52179

Similarity: Contains 5 fibronectin type-III domains

Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains

MYOM1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: MYOM1_HUMAN, P52179

Function: Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This

binding is dose dependent

Genatlas biochemistry entry for MYOM1:

sarcomeric M-band protein,myomesin 1,binding the globular head of titin and the central region of light

meromyosin,Ig superfamily,potentially involved in the assembly and/or stabilization of myofibrils,expressed in

adult muscle

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0008307	structural constituent of muscle	TAS	7505783
GO:0042802	identical protein binding	IPI	18059477
GO:0042803	protein homodimerization activity	ISS	--

MYOM1 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYOM1

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYOM1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYOM1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYOM1

miRNA Products:		miRTarBase miRNAs that target MYOM1: hsa-mir-148b-3p (MIRT019361)

		Block miRNA regulation of human, mouse, rat MYOM1 using miScript Target Protectors
		4 qRT-PCR Assays for microRNAs that regulate MYOM1:
		hsa-miR-577 hsa-miR-4279 hsa-miR-3674 hsa-miR-3935
		SwitchGear 3'UTR luciferase reporter plasmid: MYOM1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MYOM1
		Predesigned siRNA for gene silencing in human, mouse, rat MYOM1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MYOM1

Clone Products:		OriGene clones in human, mouse for MYOM1 (see all 12) OriGene ORF clones in mouse, rat for MYOM1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MYOM1 (NM_003803)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYOM1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYOM1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MYOM1
		Browse ESI BIO Cell Lines and PureStem Progenitors for MYOM1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOM1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

MYOM1_HUMAN, P52179: Cytoplasm, myofibril, sarcomere, M line (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	4
cytosol	3
nucleus	3

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005863	striated muscle myosin thick filament	TAS	6537951
GO:0030017	sarcomere	--	--
GO:0031430	M band	ISS	--

MYOM1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for MYOM1 About

See pathways by source

SuperPath

Contained pathways About

Striated Muscle Contraction

Striated Muscle Contraction

0.82

1 BioSystems Pathway for MYOM1

Striated Muscle Contraction

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for MYOM1
Interactions:

Search GeneGlobe Interaction Network for MYOM1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MYOM1 (P52179^{1, 3} ENSP00000348821⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 33)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYH9	P35579³, ENSP00000216181⁴	I2D: score=2 STRING: ENSP00000216181
TTN	Q8WZ42³	I2D: score=1
DYSF	O75923¹	EBI-5353249,EBI-2799016
MYOM1	P52179¹	EBI-5353249,EBI-5353249
MYBPC3	ENSP00000382193⁴	STRING: ENSP00000382193

About this table

Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006936	muscle contraction	IEA	--

MYOM1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for MYOM1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for MYOM1 gene (2 alternative transcripts):

NM_003803.3 NM_019856.1

Unigene Cluster for MYOM1:

Myomesin 1

Hs.464469 [show with all ESTs]

Unigene Representative Sequence: NM_003803

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000356443(uc002klp.3 uc002klq.3) ENST00000261606 ENST00000581804

ENST00000581075 ENST00000582016 ENST00000577294 ENST00000400569

miRNA Products:		Block miRNA regulation of human, mouse, rat MYOM1 using miScript Target Protectors
		4 qRT-PCR Assays for microRNAs that regulate MYOM1:
		hsa-miR-577 hsa-miR-4279 hsa-miR-3674 hsa-miR-3935
		SwitchGear 3'UTR luciferase reporter plasmid: MYOM1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MYOM1
		Predesigned siRNA for gene silencing in human, mouse, rat MYOM1

Clone Products:		OriGene clones in human, mouse for MYOM1 (see all 12) OriGene ORF clones in mouse, rat for MYOM1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MYOM1 (NM_003803)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYOM1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYOM1

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for MYOM1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat MYOM1
		QuantiTect SYBR Green Assays in human, mouse, rat MYOM1
		QuantiFast Probe-based Assays in human, mouse, rat MYOM1

Additional mRNA sequence:

AF185573.1 AJ621424.1 AK125322.1 AK302444.1 BC116183.1 BC116184.1 X69090.1

8 DOTS entries:

DT.413926 DT.91704330 DT.97778075 DT.100016864 DT.101972106 DT.121084589 DT.121084601 DT.40132532

Selected AceView cDNA sequences (see all 65):

CA398076 BM993795 CA392551 Z36268 BM698598 AF185573 AJ621424 BU736236

AA668129 F16628 NM_003803 BQ897781 CN479326 BM713338 BX485609 BM674683

AW195583 AI221348 BF056191 AK125322 AU135612 F36622 BX502479 BM128069

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

MYOM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCCGTGTCTC

About this image

MYOM1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 7) fully expand


Heart (Cardiovascular System) fully expand to see all 2 entries
Primitive Heart Tube Cells Primitive Heart Tube
Cardiomyocyte-like progenitor cells

Lung (Respiratory System)
Stem Bronchi

Fibroblasts
Dermal Fibroblasts Dorsal Dermis

Bone (Muscoskeletal System)
HyStem+BMP4-induced SK11 cells

Cartilage (Muscoskeletal System)
HyStem+BMP4-induced SK11 cells

MYOM1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

MYOM1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.464469

Custom PCR Arrays for MYOM1

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for MYOM1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat MYOM1
		QuantiTect SYBR Green Assays in human, mouse, rat MYOM1
		QuantiFast Probe-based Assays in human, mouse, rat MYOM1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOM1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for MYOM1 gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Myom1^{1 , 5}	myomesin 1^{1, 5}	84.95(n)¹ 87.91(a)¹		17 (41.87 cM)⁵ 17929¹ NM_010867.2¹ NP_034997.2¹ 71019557⁵
chicken (Gallus gallus)	Aves	MYOM1⁶	Gallus gallus myomesin 1, 185kDa (MYOM1), mRNA.	68(a)	1 ↔ 1	2(100573569-100647380)
lizard (Anolis carolinensis)	Reptilia	MYOM1⁶	myomesin 1	72(a)	1 ↔ 1	4(42503243-42590914)
African clawed frog (Xenopus laevis)	Amphibia	Xl.12595²	Xenopus laevis transcribed sequence with moderate similarity to protein spP52179 (H.sapiens) MYM1_HUMAN Myomesin 1 (190 kDa titin-associated protein) (190 kDa connectin-associated protein) less	74.84(n)		BJ071009.1
zebrafish (Danio rerio)	Actinopterygii	MYOM1 (2 of 2)⁶ myom1a⁶	myomesin 1a (skelemin)	59(a) 57(a)	1 ↔ many 1 ↔ many	7(74360032-74419118) ENSDARG00000076821 2(30631020-30674745) ENSDARG00000061249
fruit fly (Drosophila melanogaster)	Insecta	sls⁶ CG14964⁶	--	2(a) 12(a)	many ↔ many many ↔ many	3L(2039681-2115611) 3L(3172817-3178580)

ENSEMBL Gene Tree for MYOM1 (if available)
TreeFam Gene Tree for MYOM1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for MYOM1 gene

IGSF22² MYBPH² IGFN1² MYBPC2² MYBPC1² MYBPC3² MYBPHL² MYOM3²

MYOM2²

3 SIMAP similar genes for MYOM1 using alignment to 4 protein entries: MYOM1_HUMAN (see all proteins):

MYLK MYOM2 MYOM3

MYOM1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12458425^1,2	H	--	3032003(+)	`gtgtgC/Tgcacg`	2	--	int¹		0	--	--	--	--
rs112390206^1,2	C,F	--	3033600(+)	`TTTTTG/TTGAGG`	2	--	int¹		2		NA WA	4
rs143642028^1,2	C	--	3039276(+)	`TTGTA-/TTTTTT`	2	--	int¹		0	--	--	--	--
rs28613174^1,2	F	--	3039281(+)	`TTTTTT/GTTTTT`	2	--	int¹ trp³		1		WA	118
rs5822735^1,2	C	--	3048556(+)	`CGttcT/-ttttt`	2	--	int¹ trp³		1		NA	2
rs80021124^1,2	C	--	3055461(+)	`AAAAAC/ACACAC`	2	--	int¹		1		NA	2
rs13381298^1,2	C,F	--	3055729(+)	`GCTGGG/CGTTGG`	2	--	ds500¹		2		CSA WA	120
rs11659491^1,2	C,F,A,H	--	3055749(+)	`AACTTT/CCTACA`	2	--	ds500¹		9		WA NA CSA EA	371
rs139876783^1,2		--	3055781(+)	`ACCCTC/TAGCAA`	2	--	ds500¹		0	--	--	--	--
rs72858605^1,2	C,F	--	3055810(+)	`ATTTCC/AACAGC`	2	--	ds500¹		2		NA	122

HapMap Linkage Disequilibrium report for MYOM1 (3066805 - 3220106 bp)

Structural Variations
Database of Genomic Variants (DGV) 8 variations for MYOM1: About this table

Variant ID	Type	Subtype	PubMed ID
esv2661000	CNV	Deletion	23128226
esv2676971	CNV	Deletion	23128226
esv2716685	CNV	Deletion	23290073
nsv131766	CNV	Insertion	16902084
esv1010829	CNV	Insertion	20482838
nsv509681	CNV	Insertion	20534489
nsv458013	CNV	Loss	19166990
nsv909317	CNV	Gain	21882294

Human Gene Mutation Database (HGMD): MYOM1

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MYOM1

DNA2.0 Custom Variant and Variant Library Synthesis for MYOM1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 603508 OMIM disorders: --

7 diseases for MYOM1:
About MalaCards

myopia-2 blepharospasm myotonic dystrophy type 1 myotonic dystrophy

myopia hypertrophic cardiomyopathy dilated cardiomyopathy

MYOM1 for disorders About GeneDecksing

Genetic Association Database (GAD): MYOM1
Human Genome Epidemiology (HuGE) Navigator: MYOM1 (1 document)

Export disorders for MYOM1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for MYOM1 gene, integrated from 10 sources (see all 34):
(articles sorted by number of sources associating them with MYOM1)

Utopia: connect your pdf to the dynamic
world of online information

Assignment of the human gene for the sarcomeric M-band protein myomesin (MYOM1) to 18p11.31-p11.32. (PubMed id 9806852)^{1, 3, 9} Speel E.J....Hopman A.H. (Genomics 1998)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins. (PubMed id 7505783)^{1, 2} Vinkemeier U.... Fuerst D.O. (J. Cell Sci. 1993)
Myomesin is a molecular spring with adaptable elasticity. (PubMed id 15890201)^{1, 9} Schoenauer R....Agarkova I. (J. Mol. Biol. 2005)
Characterization of MR-1, a novel myofibrillogenesis regulator in human muscle. (PubMed id 15188056)^{2, 9} Li T.-B....Gong L.-M. (Acta Biochim. Biophys. Sin. 2004)
Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties. (PubMed id 22347812)¹ Pinotsis N....Wilmanns M. (PLoS Biol. 2012)
Alternative splicing of myomesin 1 gene is aberrantly regulated in myotonic dystrophy type 1. (PubMed id 21794030)¹ Koebis M....Ishiura S. (amp 2011)
A myomesin mutation associated with hypertrophic cardiomyopathy deteriorates dimerisation properties. (PubMed id 21256114)¹ Siegert R....Ozcelik C. (Biochem. Biophys. Res. Commun. 2011)
EH-myomesin splice isoform is a novel marker for dilated cardiomyopathy. (PubMed id 21069531)¹ Schoenauer R....Agarkova I. (Basic Res. Cardiol. 2011)
A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PubMed id 19460752)¹ Yeung M.L....Jeang K.T. (J. Biol. Chem. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 8736	HGNC: 7613	AceView: MYOM1	Ensembl:ENSG00000101605	euGenes: HUgn8736
ECgene: MYOM1	H-InvDB: MYOM1

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for MYOM1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MYOM1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MYOM1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for MYOM1 gene:
Search GeneIP for patents involving MYOM1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

	Browse Purified and Recombinant Proteins at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of MYOM1
	Browse Small Molecules at EMD Millipore
	Browse Kits and Assays available from EMD Millipore

	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for MYOM1		OriGene RNAi products in human, mouse, rat for MYOM1
	Browse OriGene qPCR primer pairs and template standards		Browse OriGene Protein Over-expression Lysates
	OriGene Custom Mass Spec		OriGene clones in human, mouse for MYOM1
	OriGene qSTAR qPCR primer pairs in human, mouse for MYOM1		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for MYOM1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MYOM1		OriGene Custom Protein Services for MYOM1

	Block miRNA regulation of human, mouse, rat MYOM1 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing MYOM1
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYOM1		Predesigned siRNA for gene silencing in human, mouse, rat MYOM1
	QuantiFast Probe-based Assays in human, mouse, rat MYOM1		QuantiTect SYBR Green Assays in human, mouse, rat MYOM1
	Custom PCR Arrays for MYOM1		Search Chromatin IP Primers for MYOM1
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat MYOM1		Search GeneGlobe Interaction Network for MYOM1
	Regulatory tfbs in MYOM1 promoter

	GenScript Custom Purified and Recombinant Proteins Services for MYOM1		GenScript cDNA clones with any tag delivered in your preferred vector for MYOM1
	GenScript Custom Assay Services for MYOM1		GenScript Custom overexpressing Cell Line Services for MYOM1
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for MYOM1

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	MYOM1 antibodies
	MYOM1 proteins

	Antibodies for MYOM1
	See all of Abcam's Antibodies, Kits and Proteins for MYOM1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for MYOM1
	Antibodies for MYOM1
	ELISAs for MYOM1
	CLIAs for MYOM1

Browse ESI BIO Cell Lines and PureStem Progenitors for MYOM1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOM1

	SwitchGear 3'UTR luciferase reporter plasmids for MYOM1
	SwitchGear Promoter luciferase reporter plasmids for MYOM1

Search ThermoFisher Antibodies for MYOM1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYOM1

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYOM1
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYOM1

LSBio Antibodies in human, mouse, rat for MYOM1

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

Browse compounds at ApexBio

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MYOM1 gene at Home site.

Version: 3.12.142 28 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

MYOM1 Gene

Myomesin 1

Aliases
for MYOM1 gene

Summaries
for MYOM1 gene

Genomic Views
for MYOM1 gene

Proteins
for MYOM1 gene

MYOM1 Human Recombinant Protein Products:

MYOM1 Antibody Products:

MYOM1 Assay Products:

Domains /
Families
for MYOM1 gene

Function
for MYOM1 gene

Localization
for MYOM1 gene

Pathways & Interactions
for MYOM1 gene

Drugs & Compounds
for MYOM1 gene

Transcripts
for MYOM1 gene

Expression
for MYOM1 gene

Orthologs
for MYOM1 gene

Paralogs
for MYOM1 gene

Genomic Variants
for MYOM1 gene

Disorders / Diseases
for MYOM1 gene

Publications
for MYOM1 gene

External Searches for MYOM1 gene

Genome Databases showing MYOM1 gene

Other Databases showing MYOM1 gene

Specialized Databases showing MYOM1 gene

Intellectual Property
for MYOM1 gene

Products
for MYOM1 gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

MYOM1 Gene

Myomesin 1

Aliasesfor MYOM1 gene

Summariesfor MYOM1 gene

Genomic Viewsfor MYOM1 gene

Proteinsfor MYOM1 gene

MYOM1 Human Recombinant Protein Products:

MYOM1 Antibody Products:

MYOM1 Assay Products:

Domains /Familiesfor MYOM1 gene

Functionfor MYOM1 gene

Localizationfor MYOM1 gene

Pathways & Interactionsfor MYOM1 gene

Drugs & Compoundsfor MYOM1 gene

Transcriptsfor MYOM1 gene

Expression for MYOM1 gene

Orthologsfor MYOM1 gene

Paralogsfor MYOM1 gene

Genomic Variantsfor MYOM1 gene

Disorders / Diseasesfor MYOM1 gene

Publicationsfor MYOM1 gene

External Searches for MYOM1 gene

Genome Databases showing MYOM1 gene

Other Databases showing MYOM1 gene

Specialized Databases showing MYOM1 gene

Intellectual Propertyfor MYOM1 gene

Productsfor MYOM1 gene

View Random Gene

Aliases
for MYOM1 gene

Summaries
for MYOM1 gene

Genomic Views
for MYOM1 gene

Proteins
for MYOM1 gene

Domains /
Families
for MYOM1 gene

Function
for MYOM1 gene

Localization
for MYOM1 gene

Pathways & Interactions
for MYOM1 gene

Drugs & Compounds
for MYOM1 gene

Transcripts
for MYOM1 gene

Expression
for MYOM1 gene

Orthologs
for MYOM1 gene

Paralogs
for MYOM1 gene

Genomic Variants
for MYOM1 gene

Disorders / Diseases
for MYOM1 gene

Publications
for MYOM1 gene

Intellectual Property
for MYOM1 gene

Products
for MYOM1 gene