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MYOM1 Gene

protein-coding   GIFtS: 57
GCID: GC18M003056

Myomesin 1

(Previous names: myomesin 1 (skelemin) (185kD), myomesin 1 (skelemin) 185kDa,...)
  See MYOM1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myomesin 11 2     SKELEMIN2 5
Myomesin 1 (Skelemin) 185kDa1 2     Myomesin 1 (Skelemin) (185kD)1
Myomesin 1, 185kDa1 2     skelemin1
Myomesin Family Member 12 3     EH-myomesin2
190 KDa Connectin-Associated Protein2 3     Myomesin (M-Protein) 1 (190kD)2
190 KDa Titin-Associated Protein2 3     myomesin-12

External Ids:    HGNC: 76131   Entrez Gene: 87362   Ensembl: ENSG000001016057   OMIM: 6035085   UniProtKB: P521793   

Export aliases for MYOM1 gene to outside databases

Previous GC identifers: GC18M003315 GC18M003054


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYOM1 Gene:
The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres,
the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly
to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein,
myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong
homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and
myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement
II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region.
The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M
band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of
immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been
identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for MYOM1 Gene:
MYOM1 (myomesin 1) is a protein-coding gene. Diseases associated with MYOM1 include myopia-2. GO annotations related to this gene include structural constituent of muscle and protein homodimerization activity. An important paralog of this gene is IGSF22.

UniProtKB/Swiss-Prot: MYOM1_HUMAN, P52179
Function: Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This
binding is dose dependent

Gene Wiki entry for MYOM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010859.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYOM1 gene promoter:
         Max1   AML1a   p300   Lmo2   GATA-1   C/EBPalpha   YY1   Evi-1   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYOM1 promoter sequence
   Search Chromatin IP Primers for MYOM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYOM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.31   Ensembl cytogenetic band:  18p11.31   HGNC cytogenetic band: 18p11.31

MYOM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYOM1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M003056:  view genomic region     (about GC identifiers)

Start:
3,066,805 bp from pter      End:
3,220,106 bp from pter
Size:
153,302 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MYOM1_HUMAN, P52179 (See protein sequence)
Recommended Name: Myomesin-1  
Size: 1685 amino acids; 187627 Da
Subunit: Homodimer (By similarity). Interacts with TTN/titin (By similarity). Interacts with PNKD
Sequence caution: Sequence=CAA48833.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for MYOM1:
2R15 (3D)        2Y23 (3D)        2Y25 (3D)        3RBS (3D)    
Secondary accessions: Q14BD6 Q6H969 Q6ZUU0
Alternative splicing: 2 isoforms:  P52179-1   P52179-2   

Explore the universe of human proteins at neXtProt for MYOM1: NX_P52179

Explore proteomics data for MYOM1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYOM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003794.3  NP_062830.1  

    ENSEMBL proteins: 
     ENSP00000348821   ENSP00000261606   ENSP00000462039   ENSP00000383413  

    MYOM1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MYOM1

     
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    Search eBioscience for ELISAs for MYOM1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing

    Selected InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry P52179

    ProtoNet protein and cluster: P52179

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB003962 Fibronectin type III repeat signature


    UniProtKB/Swiss-Prot: MYOM1_HUMAN, P52179
    Similarity: Contains 5 fibronectin type-III domains
    Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with MYOM1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYOM1_HUMAN, P52179
    Function: Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This
    binding is dose dependent

         Genatlas biochemistry entry for MYOM1:
    sarcomeric M-band protein,myomesin 1,binding the globular head of titin and the central region of light
    meromyosin,Ig superfamily,potentially involved in the assembly and/or stabilization of myofibrils,expressed in
    adult muscle

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008307structural constituent of muscle TAS7505783
    GO:0042802identical protein binding IPI18059477
    GO:0042803protein homodimerization activity ISS--
         
    Find genes that share ontologies with MYOM1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYOM1
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    miRNA
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    miRTarBase miRNAs that target MYOM1:
    hsa-mir-148b-3p (MIRT019361)

    Block miRNA regulation of human, mouse, rat MYOM1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MYOM1:
    hsa-miR-577 hsa-miR-4279 hsa-miR-3674 hsa-miR-3935
    SwitchGear 3'UTR luciferase reporter plasmidMYOM1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MYOM1

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    GenScript: all cDNA clones in your preferred vector (see all 2): MYOM1 (NM_003803)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYOM1_HUMAN, P52179: Cytoplasm, myofibril, sarcomere, M line (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    nucleus3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005863striated muscle myosin thick filament TAS6537951
    GO:0030017sarcomere ----
    GO:0031430M band ISS--

    Find genes that share ontologies with MYOM1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYOM1 About    
    See pathways by source

    SuperPathContained pathways About
    1Striated Muscle Contraction
    Striated Muscle Contraction0.82


    1 BioSystems Pathway for MYOM1
        Striated Muscle Contraction


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYOM1
    Interactions:

        Search GeneGlobe Interaction Network for MYOM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYOM1 (P521791, 3 ENSP000003488214) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYH9P355793, ENSP000002161814I2D: score=2 STRING: ENSP00000216181
    TTNQ8WZ423I2D: score=1 
    DYSFO759231EBI-5353249,EBI-2799016
    MYOM1P521791EBI-5353249,EBI-5353249
    MYBPC3ENSP000003821934STRING: ENSP00000382193
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction IEA--

    Find genes that share ontologies with MYOM1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYOM1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYOM1 gene (2 alternative transcripts): 
    NM_003803.3  NM_019856.1  

    Unigene Cluster for MYOM1:

    Myomesin 1
    Hs.464469  [show with all ESTs]
    Unigene Representative Sequence: NM_003803
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356443(uc002klp.3 uc002klq.3) ENST00000261606 ENST00000581804
    ENST00000581075 ENST00000582016 ENST00000577294 ENST00000400569
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate MYOM1:
    hsa-miR-577 hsa-miR-4279 hsa-miR-3674 hsa-miR-3935
    SwitchGear 3'UTR luciferase reporter plasmidMYOM1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYOM1
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYOM1
      QuantiTect SYBR Green Assays in human, mouse, rat MYOM1
      QuantiFast Probe-based Assays in human, mouse, rat MYOM1

    Additional mRNA sequence: 

    AF185573.1 AJ621424.1 AK125322.1 AK302444.1 BC116183.1 BC116184.1 X69090.1 

    8 DOTS entries:

    DT.413926  DT.91704330  DT.97778075  DT.100016864  DT.101972106  DT.121084589  DT.121084601  DT.40132532 

    Selected AceView cDNA sequences (see all 65):

    CA398076 BM993795 CA392551 Z36268 BM698598 AF185573 AJ621424 BU736236 
    AA668129 F16628 NM_003803 BQ897781 CN479326 BM713338 BX485609 BM674683 
    AW195583 AI221348 BF056191 AK125322 AU135612 F36622 BX502479 BM128069 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYOM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGTGTCTC
    MYOM1 Expression
    About this image


    MYOM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Cardiomyocyte-like progenitor cells
     
     Lung (Respiratory System)
             Stem Bronchi
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
     
     Bone (Muscoskeletal System)
             HyStem+BMP4-induced SK11 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+BMP4-induced SK11 cells
    MYOM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYOM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.464469
        Custom PCR Arrays for MYOM1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MYOM1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myom11 , 5 myomesin 11, 5 84.95(n)1
    87.91(a)1
      17 (41.87 cM)5
    179291  NM_010867.21  NP_034997.21 
     710195575 
    chicken
    (Gallus gallus)
    Aves MYOM16
    Gallus gallus myomesin 1, 185kDa (MYOM1), mRNA.
    68(a)
    1 ↔ 1
    2(100573569-100647380)
    lizard
    (Anolis carolinensis)
    Reptilia MYOM16
    myomesin 1
    72(a)
    1 ↔ 1
    4(42503243-42590914)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.125952 Xenopus laevis transcribed sequence with moderate similarity to protein spP52179 (H.sapiens) MYM1_HUMAN Myomesin 1 (190 kDa titin-associated protein) (190 kDa connectin-associated protein) less 74.84(n)    BJ071009.1 
    zebrafish
    (Danio rerio)
    Actinopterygii MYOM1 (2 of 2)6
    myom1a6
    myomesin 1a (skelemin)
    59(a)
    57(a)
    1 ↔ many
    1 ↔ many
    7(74360032-74419118) ENSDARG00000076821
    2(30631020-30674745) ENSDARG00000061249
    fruit fly
    (Drosophila melanogaster)
    Insecta sls6
    CG149646
    --
    2(a)
    12(a)
    many ↔ many
    many ↔ many
    3L(2039681-2115611)
    3L(3172817-3178580)


    ENSEMBL Gene Tree for MYOM1 (if available)
    TreeFam Gene Tree for MYOM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYOM1 gene
    IGSF222  MYBPH2  IGFN12  MYBPC22  MYBPC12  MYBPC32  MYBPHL2  MYOM32  
    MYOM22  
    3 SIMAP similar genes for MYOM1 using alignment to 4 protein entries:     MYOM1_HUMAN (see all proteins):
    MYLK    MYOM2    MYOM3

    Find genes that share paralogs with MYOM1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYOM1 (see all 3925)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124584251,2
    H--3032003(+) gtgtgC/Tgcacg 2 -- int10--------
    rs1123902061,2
    C,F--3033600(+) TTTTTG/TTGAGG 2 -- int12Minor allele frequency- T:0.50NA WA 4
    rs1436420281,2
    C--3039276(+) TTGTA-/TTTTTT 2 -- int10--------
    rs286131741,2
    F--3039281(+) TTTTTT/GTTTTT 2 -- int1 trp31Minor allele frequency- G:0.14WA 118
    rs58227351,2
    C--3048556(+) CGttcT/-ttttt 2 -- int1 trp31Minor allele frequency- -:0.50NA 2
    rs800211241,2
    C--3055461(+) AAAAAC/ACACAC 2 -- int11Minor allele frequency- A:0.50NA 2
    rs133812981,2
    C,F--3055729(+) GCTGGG/CGTTGG 2 -- ds50012Minor allele frequency- C:0.05CSA WA 120
    rs116594911,2
    C,F,A,H--3055749(+) AACTTT/CCTACA 2 -- ds50019Minor allele frequency- C:0.28WA NA CSA EA 371
    rs1398767831,2
    --3055781(+) ACCCTC/TAGCAA 2 -- ds50010--------
    rs728586051,2
    C,F--3055810(+) ATTTCC/AACAGC 2 -- ds50012Minor allele frequency- A:0.13NA 122

    HapMap Linkage Disequilibrium report for MYOM1 (3066805 - 3220106 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MYOM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661000CNV Deletion23128226
    esv2676971CNV Deletion23128226
    esv2716685CNV Deletion23290073
    nsv131766CNV Insertion16902084
    esv1010829CNV Insertion20482838
    nsv509681CNV Insertion20534489
    nsv458013CNV Loss19166990
    nsv909317CNV Gain21882294

    Human Gene Mutation Database (HGMD): MYOM1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYOM1
    DNA2.0 Custom Variant and Variant Library Synthesis for MYOM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603508    OMIM disorders: --

    1 disease for MYOM1:    
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    myopia-2


    Find genes that share disorders with MYOM1           About GenesLikeMe

    Genetic Association Database (GAD): MYOM1
    Human Genome Epidemiology (HuGE) Navigator: MYOM1 (1 document)

    Export disorders for MYOM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYOM1 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with MYOM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human gene for the sarcomeric M-band protein myomesin (MYOM1) to 18p11.31-p11.32. (PubMed id 9806852)1, 3, 9 Speel E.J....Hopman A.H. (Genomics 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins. (PubMed id 7505783)1, 2 Vinkemeier U.... Fuerst D.O. (J. Cell Sci. 1993)
    4. Myomesin is a molecular spring with adaptable elasticity. (PubMed id 15890201)1, 9 Schoenauer R....Agarkova I. (J. Mol. Biol. 2005)
    5. Characterization of MR-1, a novel myofibrillogenesis regulator in human muscle. (PubMed id 15188056)2, 9 Li T.-B....Gong L.-M. (Acta Biochim. Biophys. Sin. 2004)
    6. Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties. (PubMed id 22347812)1 Pinotsis N....Wilmanns M. (PLoS Biol. 2012)
    7. Alternative splicing of myomesin 1 gene is aberrantly regulated in myotonic dystrophy type 1. (PubMed id 21794030)1 Koebis M....Ishiura S. (amp 2011)
    8. A myomesin mutation associated with hypertrophic cardiomyopathy deteriorates dimerisation properties. (PubMed id 21256114)1 Siegert R....Ozcelik C. (Biochem. Biophys. Res. Commun. 2011)
    9. EH-myomesin splice isoform is a novel marker for dilated cardiomyopathy. (PubMed id 21069531)1 Schoenauer R....Agarkova I. (Basic Res. Cardiol. 2011)
    10. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PubMed id 19460752)1 Yeung M.L....Jeang K.T. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8736 HGNC: 7613 AceView: MYOM1 Ensembl:ENSG00000101605 euGenes: HUgn8736
    ECgene: MYOM1 H-InvDB: MYOM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYOM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYOM1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYOM1 gene:
    Search GeneIP for patents involving MYOM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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