Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MYOG Gene

protein-coding   GIFtS: 64
GCID: GC01M203052

Myogenin (Myogenic Factor 4)


(Previous symbol: MYF4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Myogenin (Myogenic Factor 4)1 2     myf-42
MYF41 2 3 5     myogenin2
Class C Basic Helix-Loop-Helix Protein 32 3     BHLHC33
Myogenic Factor 42 3     Myf-43
bHLHc32 3     

External Ids:    HGNC: 76121   Entrez Gene: 46562   Ensembl: ENSG000001221807   OMIM: 1599805   UniProtKB: P151733   

Export aliases for MYOG gene to outside databases

Previous GC identifers: GC01M200735 GC01M198482 GC01M199518 GC01M200340 GC01M199783 GC01M201318 GC01M174217


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MYOG Gene:
Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue
culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH)
proteins. It is essential for the development of functional skeletal muscle. (provided by RefSeq, Jul 2008)

GeneCards Summary for MYOG Gene:
MYOG (myogenin (myogenic factor 4)) is a protein-coding gene. Diseases associated with MYOG include malignant mesenchymoma, and gallbladder sarcoma. GO annotations related to this gene include E-box binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MYF5.

UniProtKB/Swiss-Prot: MYOG_HUMAN, P15173
Function: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and
plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of
functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle
growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required
for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression
initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci
with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies
muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer
factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure
at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the
up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to
the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle
cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces
fibroblasts to differentiate into myoblasts (By similarity)

Gene Wiki entry for MYOG (Myogenin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYOG gene promoter:
         AP-2alpha isoform 3   p53   AML1a   MyoD   AP-2alpha isoform 2   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYOG promoter sequence
   Search Chromatin IP Primers for MYOG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYOG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31-q41   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q31-q41

MYOG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYOG gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M203052:  view genomic region     (about GC identifiers)

Start:
203,052,257 bp from pter      End:
203,055,377 bp from pter
Size:
3,121 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MYOG_HUMAN, P15173 (See protein sequence)
Recommended Name: Myogenin  
Size: 224 amino acids; 25037 Da
Subunit: Homodimer and heterodimer with E12; heterodimerization enhances MYOG DNA-binding and transcriptional
activities. Interacts with SMARCA4/BRG1/BAF190A. Interacts (via C-terminus region) with SSRP1 and SUPT16H; the
interaction is indicative of an interaction with the FACT complex (By similarity)
Secondary accessions: Q53XW6

Explore the universe of human proteins at neXtProt for MYOG: NX_P15173

Explore proteomics data for MYOG at MOPED

Post-translational modifications: 

  • Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner.
    Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles (By
    similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYOG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002470.2  
    ENSEMBL proteins: 
     ENSP00000241651  
    Reactome Protein details: P15173

    MYOG Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MYOG
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MYOG
    GenScript Custom Purified and Recombinant Proteins Services for MYOG
    Novus Biologicals MYOG Protein
    Novus Biologicals MYOG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYOG

    MYOG Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MYOG
    R&D Systems Antibodies for MYOG (Myogenin)
    OriGene Antibodies for MYOG
    OriGene Custom Antibody Services for MYOG
    Novus Biologicals MYOG Antibodies
    Abcam antibodies for MYOG
    Cloud-Clone Corp. Antibodies for MYOG
    ThermoFisher Antibody for MYOG
    LSBio Antibodies in human, mouse, rat for MYOG

    MYOG Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MYOG
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYOG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYOG
    Cloud-Clone Corp. CLIAs for MYOG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    2 InterPro protein domains:
     IPR002546 Basic
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry P15173

    ProtoNet protein and cluster: P15173

    2 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB002546 Myogenic basic muscle-specific protein


    UniProtKB/Swiss-Prot: MYOG_HUMAN, P15173
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    MYOG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYOG_HUMAN, P15173
    Function: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and
    plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of
    functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle
    growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required
    for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression
    initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci
    with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies
    muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer
    factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure
    at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the
    up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to
    the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle
    cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces
    fibroblasts to differentiate into myoblasts (By similarity)

         Genatlas biochemistry entry for MYOG:
    myogenic factor 4,transcription activator (myogenin),required for the differentiation of skeletal muscle

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding ISS--
    GO:0000987core promoter proximal region sequence-specific DNA binding IEA--
    GO:0001047core promoter binding ISS--
    GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription TAS19783823
    GO:0003677DNA binding ----
         
    MYOG for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Myog):
     adipose tissue  behavior/neurological  embryogenesis  growth/size/body  homeostasis/metabolism 
     integument  mortality/aging  muscle  normal  respiratory system 
     skeleton 

    MYOG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MYOG: Myogtm1Yin Myogtm1Whk

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYOG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYOG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYOG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYOG

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  AACAGCTG 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYOG:
    hsa-mir-26b-5p (MIRT030010)

    Block miRNA regulation of human, mouse, rat MYOG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYOG (see all 14):
    hsa-miR-579 hsa-miR-4324 hsa-miR-548p hsa-miR-328 hsa-miR-769-5p hsa-miR-548aa hsa-miR-664 hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidMYOG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MYOG
    Predesigned siRNA for gene silencing in human, mouse, rat MYOG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYOG

    Clone
    Products:
         
    OriGene clones in human, mouse for MYOG (see all 5)
    OriGene ORF clones in mouse, rat for MYOG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYOG (NM_002479)
    Sino Biological Human cDNA Clone for MYOG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYOG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYOG

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MYOG
    Browse ESI BIO Cell Lines and PureStem Progenitors for MYOG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MYOG_HUMAN, P15173: Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with
    SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription
    initiation in developing embryos (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton3
    extracellular2
    endoplasmic reticulum1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex ISS--
    GO:0032993protein-DNA complex ISS--

    MYOG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MYOG About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1CDO in myogenesis
    CDO in myogenesis1.00
    Myogenesis1.00
    2L1CAM interactions
    Developmental Biology0.63
    3Immune response Function of MEF2 in T lymphocytes
    Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis0.38
    4Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    5Id Signaling Pathway
    Id Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for MYOG
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

    3 BioSystems Pathways for MYOG
        Hypertrophy Model
    Id Signaling Pathway
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    1 Reactome Pathway for MYOG
        CDO in myogenesis



    MYOG for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MYOG: 
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MYOG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYOG (P151732, 3 ENSP000002416514) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRFP118312, 3, ENSP000002653544MINT-16345 MINT-16346 I2D: score=4 STRING: ENSP00000265354
    CALM1P621583, ENSP000003494674I2D: score=6 STRING: ENSP00000349467
    CALM2P621583I2D: score=6 
    CALM3P621583I2D: score=6 
    POLR2CP193873, ENSP000002192524I2D: score=3 STRING: ENSP00000219252
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007049cell cycle IEA--
    GO:0007517muscle organ development ----
    GO:0007519skeletal muscle tissue development TAS10329008

    MYOG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYOG

    Selected Novoseek inferred chemical compound relationships for MYOG gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 50.2 45 12783039 (3), 1658626 (2), 19573231 (2), 1312093 (1) (see all 38)
    ly294002 41.5 6 10896679 (1), 9790996 (1), 9849961 (1), 11861503 (1) (see all 6)
    acetylcholine 37.2 16 10095433 (2), 9593756 (2), 9836066 (2), 7969143 (1) (see all 13)
    c2ceramide 17.4 2 15256490 (1), 16777978 (1)
    ribonucleic acid 15.5 1 10951440 (1)
    bromodeoxyuridine 13.2 2 11900489 (1), 19515904 (1)
    retinoic acid 6.1 5 9218485 (1), 1341049 (1), 8194491 (1), 15674337 (1)
    butyrate 6.1 6 1328872 (3), 9218485 (1), 8806451 (1)
    estrogen 4.79 1 20123451 (1)
    glucose 2.64 4 8702591 (1), 9600108 (1), 9832443 (1)



    MYOG for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MYOG gene: 
    NM_002479.5  

    Unigene Cluster for MYOG:

    Myogenin (myogenic factor 4)
    Hs.2830  [show with all ESTs]
    Unigene Representative Sequence: NM_002479
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000241651(uc001gzd.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MYOG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYOG (see all 14):
    hsa-miR-579 hsa-miR-4324 hsa-miR-548p hsa-miR-328 hsa-miR-769-5p hsa-miR-548aa hsa-miR-664 hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidMYOG 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MYOG
    Predesigned siRNA for gene silencing in human, mouse, rat MYOG
    Clone
    Products:
         
    OriGene clones in human, mouse for MYOG (see all 5)
    OriGene ORF clones in mouse, rat for MYOG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYOG (NM_002479)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYOG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYOG
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MYOG
    OriGene qSTAR qPCR primer pairs in human, mouse for MYOG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYOG
      QuantiTect SYBR Green Assays in human, mouse, rat MYOG
      QuantiFast Probe-based Assays in human, mouse, rat MYOG

    Additional mRNA sequence: 

    BC053899.1 BT007233.1 X17651.1 

    2 DOTS entries:

    DT.92465213  DT.40106339 

    10 AceView cDNA sequences:

    NM_002479 BC053899 BT007233 X17651 AW469592 AI291603 BF306781 BQ952130 
    BE294922 BU189532 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MYOG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGGTTAAC
    MYOG Expression
    About this image


    MYOG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 58 entries
             Mononuclear Myocytes Mandibular Arch Muscles
             Myogenic cells
             Human Skeletal Muscle Satellite Cells (HSkMSC)   
     
     Somite (Muscoskeletal System)    fully expand to see all 32 entries
             Myoblasts Cervical Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 10 entries
             Myoblasts Forelimb Ventral Muscles
     
     Tooth (Integumentary System)    fully expand to see all 2 entries
             Stem cells from human exfoliated deciduous teeth (family)
     
     NULL (Uncategorized)
             Expanded PAX7 cells
    MYOG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYOG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2830
        Pathway & Disease-focused RT2 Profiler PCR Array including MYOG: 
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MYOG
    OriGene qSTAR qPCR primer pairs in human, mouse for MYOG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYOG
    QuantiTect SYBR Green Assays in human, mouse, rat MYOG
    QuantiFast Probe-based Assays in human, mouse, rat MYOG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MYOG gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myog1 , 5 myogenin1, 5 90.62(n)1
    95.09(a)1
      1 (58.18 cM)5
    179281  NM_031189.21  NP_112466.11 
     1342900045 
    chicken
    (Gallus gallus)
    Aves MYOG1 myogenin (myogenic factor 4) 74.44(n)
    72.65(a)
      374004  NM_204184.1  NP_989515.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYOG6
    myogenin (myogenic factor 4)
    60(a)
    1 ↔ 1
    4(133320820-133326597)
    African clawed frog
    (Xenopus laevis)
    Amphibia AY046532.12   -- 76.52(n)    AY046532.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myog2 myogenin 79.62(n)   30200  AF202639.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nau6
    nautilus
    24(a)
    1 → many
    3R(19538536-19544079)
    worm
    (Caenorhabditis elegans)
    Secernentea hlh-16
    Protein HLH-1, isoform b
    24(a)
    1 → many
    II(4518560-4522457) WBGene00001948


    ENSEMBL Gene Tree for MYOG (if available)
    TreeFam Gene Tree for MYOG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MYOG gene
    MYF52  MYOD12  MYF62  
    4 SIMAP similar genes for MYOG using alignment to 2 protein entries:     MYOG_HUMAN (see all proteins):
    MYF4    MYF5    MYF6    MYOD1

    MYOG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MYOG (see all 173)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1885819401,2
    --203051758(+) GCTATC/TTGGCC 1 -- ds50010--------
    rs1420838601,2
    --203051775(+) GAAATG/TACAGT 1 -- ds50010--------
    rs1929494411,2
    --203051868(+) GGGAAA/TCCACA 1 -- ds50010--------
    rs120923911,2
    C--203051890(+) TGCACC/GTTGGC 1 -- ds50013Minor allele frequency- G:0.17NA WA 240
    rs1403972961,2
    --203052014(+) AGCCAA/GTTGTC 1 -- ds50010--------
    rs1847575801,2
    --203052024(+) CCTCCA/GTGTCC 1 -- ds50010--------
    rs618210921,2
    C,F--203052054(+) TCTGGT/GCTCCA 1 -- ds50012Minor allele frequency- G:0.17NA EA 240
    rs121427531,2
    C--203052177(+) ACCCAC/TTAGGG 1 -- ds50012Minor allele frequency- T:0.00NA 4
    rs1443273751,2
    C--203052247(+) CATCA-/CCCCCGAC 1 -- cds10--------
    rs1896285481,2
    --203052249(+) ATCACC/TGACAC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MYOG (203052257 - 203055377 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MYOG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832370CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYOG
    DNA2.0 Custom Variant and Variant Library Synthesis for MYOG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 159980    OMIM disorders: --

    Selected diseases for MYOG (see all 42):    
    About MalaCards
    malignant mesenchymoma    gallbladder sarcoma    mesenchymoma    undifferentiated embryonal sarcoma of the liver
    melanotic neuroectodermal tumor    botryoid rhabdomyosarcoma    tenosynovial giant cell tumor    pleomorphic rhabdomyosarcoma
    embryonal rhabdomyosarcoma    desmoplastic small round cell tumor    embryonal sarcoma    fasciitis
    mesenchymal chondrosarcoma    alveolar rhabdomyosarcoma    sertoli-leydig cell tumor    alveolar soft part sarcoma
    giant cell tumor    malignant peripheral nerve sheath tumor    fibrous histiocytoma    leiomyosarcoma

    6 diseases from the University of Copenhagen DISEASES database for MYOG:
    Rhabdomyosarcoma     Myopathy     Sarcoma     Leiomyosarcoma
    Neuropathy     Malignant mesenchymoma

    MYOG for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MYOG gene (see all 30)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rhabdomyosarcoma 84.8 46 10095433 (4), 10666368 (4), 19372547 (3), 18493875 (3) (see all 26)
    rhabdomyosarcoma alveolar 80.4 8 10666368 (4), 18727437 (1), 18540440 (1), 18705836 (1)
    rhabdomyosarcoma embryonal 80.3 14 10666368 (5), 16945640 (2), 16010486 (1), 17549403 (1) (see all 7)
    myosarcoma 61.5 2 11473460 (1), 9796719 (1)
    ewings sarcoma 55.5 2 10227726 (1), 12426678 (1)
    leiomyosarcoma 53 3 11688574 (1), 10227726 (1), 11473460 (1)
    sarcoma 50.2 1 16785789 (1)
    myopathy, congenital 45.5 12 10329008 (3), 16977479 (2)
    hypertrophy 38.5 4 17395765 (2), 12716875 (1), 10370140 (1)
    malignant fibrous histiocytoma 37.2 1 11688574 (1)

    Genetic Association Database (GAD): MYOG
    Human Genome Epidemiology (HuGE) Navigator: MYOG (2 documents)

    Export disorders for MYOG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MYOG gene, integrated from 10 sources (see all 492):
    (articles sorted by number of sources associating them with MYOG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcription of the muscle regulatory gene Myf4 is regulated by serum components, peptide growth factors and signaling pathways involving G proteins. (PubMed id 1659574)1, 2, 9 Salminen A....Arnold H.H. (J. Cell Biol. 1991)
    2. Human bHLH transcription factor gene myogenin (MYOG): genomic sequence and negative mutation analysis in patients with severe congenital myopathies. (PubMed id 10329008)1, 3, 9 Tseng B.S.... Butler I.J. (Genomics 1999)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products. (PubMed id 2583111)1, 2 Braun T....Arnold H.H. (EMBO J. 1989)
    6. Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization. (PubMed id 2163343)1, 9 Brennan T.J. and Olson E.N. (amp 1990)
    7. [Correlation between myogenin and transforming growth factor-beta1 expression in long-term human denervated posterior cricoarytenoid muscles]. (PubMed id 19961777)1, 9 Zhang X....Chen S.C. (Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2009)
    8. Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis. (PubMed id 18676376)1, 9 Armand A.S....De Windt L.J. (J. Biol. Chem. 2008)
    9. Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiation. (PubMed id 15084602)1, 9 Konig S....Bernheim L. (J. Biol. Chem. 2004)
    10. Effects of one bout of endurance exercise on the expression of myogenin in human quadriceps muscle. (PubMed id 14997318)1, 9 Kadi F....Henriksson J. (Histochem. Cell Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4656 HGNC: 7612 AceView: MYOG Ensembl:ENSG00000122180 euGenes: HUgn4656
    ECgene: MYOG H-InvDB: MYOG

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MYOG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MYOG gene:
    Search GeneIP for patents involving MYOG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of MYOG
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for MYOG (Myogenin)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MYOG   OriGene RNAi products in human, mouse, rat for MYOG  
     OriGene qPCR primer pairs and template standards for MYOG   OriGene Protein Over-expression Lysate for MYOG  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MYOG  
     OriGene qSTAR qPCR primer pairs in human, mouse for MYOG   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MYOG   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MYOG   OriGene Custom Protein Services for MYOG  

     
     
     Block miRNA regulation of human, mouse, rat MYOG using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MYOG
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYOG Predesigned siRNA for gene silencing in human, mouse, rat MYOG
     QuantiFast Probe-based Assays in human, mouse, rat MYOG QuantiTect SYBR Green Assays in human, mouse, rat MYOG
     PCR Arrays including human, mouse, rat MYOG Search Chromatin IP Primers for MYOG
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYOG  GeneGlobe Interaction Network for MYOG
     Regulatory tfbs in MYOG promoter
     GenScript Custom Purified and Recombinant Proteins Services for MYOG GenScript cDNA clones with any tag delivered in your preferred vector for MYOG
     GenScript Custom Assay Services for MYOG GenScript Custom overexpressing Cell Line Services for MYOG
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MYOG
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for MYOG
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MYOG antibodies
     MYOG proteins
     MYOG lysates
     Antibodies for MYOG
     See all of Abcam's Antibodies, Kits and Proteins for MYOG
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MYOG
     Antibodies for MYOG
     ELISAs for MYOG
     CLIAs for MYOG



     Browse ESI BIO Cell Lines and PureStem Progenitors for MYOG
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOG
     SwitchGear 3'UTR luciferase reporter plasmids for MYOG
     SwitchGear Promoter luciferase reporter plasmids for MYOG
     ThermoFisher Antibody for MYOG
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYOG
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYOG
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYOG
     LSBio Antibodies in human, mouse, rat for MYOG
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MYOG gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4