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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYOG Gene

protein-coding   GIFtS: 63
GCID: GC01M203052

Myogenin (Myogenic Factor 4)


(Previous symbol: MYF4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Myogenin (Myogenic Factor 4)1 2     myf-42
MYF41 2 3 5     myogenin2
Class C Basic Helix-Loop-Helix Protein 32 3     BHLHC33
Myogenic Factor 42 3     Myf-43
bHLHc32 3     

External Ids:    HGNC: 76121   Entrez Gene: 46562   Ensembl: ENSG000001221807   OMIM: 1599805   UniProtKB: P151733   

Export aliases for MYOG gene to outside databases

Previous GC identifers: GC01M200735 GC01M198482 GC01M199518 GC01M200340 GC01M199783 GC01M201318 GC01M174217


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYOG Gene:
Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue
culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH)
proteins. It is essential for the development of functional skeletal muscle. (provided by RefSeq, Jul 2008)

GeneCards Summary for MYOG Gene: 
MYOG (myogenin (myogenic factor 4)) is a protein-coding gene. Diseases associated with MYOG include gallbladder sarcoma, and undifferentiated embryonal sarcoma of the liver, and among its related super-pathways are Myogenesis and Axon guidance. GO annotations related to this gene include E-box binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MYF5.

UniProtKB/Swiss-Prot: MYOG_HUMAN, P15173
Function: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into
myoblasts. Probable sequence specific DNA-binding protein

Gene Wiki entry for MYOG (Myogenin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYOG gene promoter:
         AP-2alpha isoform 3   p53   AML1a   MyoD   AP-2alpha isoform 2   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYOG promoter sequence
   Search SABiosciences Chromatin IP Primers for MYOG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYOG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31-q41   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q31-q41

MYOG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYOG gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M203052:  view genomic region     (about GC identifiers)

Start:
203,052,257 bp from pter      End:
203,055,377 bp from pter
Size:
3,121 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MYOG_HUMAN, P15173 (See protein sequence)
Recommended Name: Myogenin  
Size: 224 amino acids; 25037 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein
Subcellular location: Nucleus
Secondary accessions: Q53XW6

Explore the universe of human proteins at neXtProt for MYOG: NX_P15173

Explore proteomics data for MYOG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P15173

  • MYOG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYOG Protein Expression
    REFSEQ proteins: NP_002470.2  
    ENSEMBL proteins: 
     ENSP00000241651  
    Reactome Protein details: P15173
    Human Recombinant Protein Products for MYOG: 
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    OriGene Protein Over-expression Lysate for MYOG
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    OriGene Custom Protein Services for MYOG
    GenScript Custom Purified and Recombinant Proteins Services for MYOG
    Novus Biologicals MYOG Protein
    Novus Biologicals MYOG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYOG 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex ISS--
    GO:0032993protein-DNA complex ISS--

    MYOG for ontologies           About GeneDecksing



    MYOG Antibody Products: 
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    R&D Systems Antibodies for MYOG (Myogenin)
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    Cloud-Clone Corp. Antibodies for MYOG 
    ThermoFisher Antibody for MYOG
    LSBio Antibodies in human, mouse, rat for MYOG 

    Assay Products for MYOG: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MYOG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYOG 
    Cloud-Clone Corp. CLIAs for MYOG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bHLH: Basic helix-loop-helix proteins

    2 InterPro protein domains:
     IPR002546 Basic
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry P15173

    ProtoNet protein and cluster: P15173

    2 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB002546 Myogenic basic muscle-specific protein


    UniProtKB/Swiss-Prot: MYOG_HUMAN, P15173
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    MYOG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYOG_HUMAN, P15173
    Function: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into
    myoblasts. Probable sequence specific DNA-binding protein

         Genatlas biochemistry entry for MYOG:
    myogenic factor 4,transcription activator (myogenin),required for the differentiation of skeletal muscle

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding ISS--
    GO:0000987core promoter proximal region sequence-specific DNA binding IEA--
    GO:0001047core promoter binding ISS--
    GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription TAS19783823
    GO:0003677DNA binding ----
         
    MYOG for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Myog):
     adipose tissue  behavior/neurological  embryogenesis  growth/size  homeostasis/metabolism 
     integument  mortality/aging  muscle  normal  respiratory system 
     skeleton 

    MYOG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MYOG: Myogtm1Yin Myogtm1Whk

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MYOG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MYOG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYOG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYOG 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYOG
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate MYOG (see all 14):
    hsa-miR-579 hsa-miR-4324 hsa-miR-548p hsa-miR-328 hsa-miR-769-5p hsa-miR-548aa hsa-miR-664 hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidMYOG 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    OriGene clones in human, mouse for MYOG (see all 6)
    OriGene ORF clones in mouse, rat for MYOG
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    GenScript: all cDNA clones in your preferred vector: MYOG (NM_002479)
    Sino Biological Human cDNA Clone for MYOG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYOG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYOG
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                         Customized lentivirus expression plasmids for stable overexpression of MYOG 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MYOG About                                                                                                See pathways by source

    SuperPathContained pathways About
    1CDO in myogenesis
    CDO in myogenesis1.00
    Myogenesis1.00
    2Axon guidance
    Developmental Biology0.69
    3Immune response Function of MEF2 in T lymphocytes
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis0.38
    4Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    5Id Signaling Pathway
    Id Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MYOG
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis


    1 GeneGo (Thomson Reuters) Pathway for MYOG
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

    2 BioSystems Pathways for MYOG
        Id Signaling Pathway
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    3        Reactome Pathways for MYOG
        Developmental Biology
    Myogenesis
    CDO in myogenesis



    MYOG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYOG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for MYOG (P151732, 3 ENSP000002416514) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRFP118312, 3, ENSP000002653544MINT-16345 MINT-16346 I2D: score=4 STRING: ENSP00000265354
    CALM1P621583, ENSP000003494674I2D: score=6 STRING: ENSP00000349467
    CALM2P621583I2D: score=6 
    CALM3P621583I2D: score=6 
    POLR2CP193873, ENSP000002192524I2D: score=3 STRING: ENSP00000219252
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007517muscle organ development ----
    GO:0007519skeletal muscle tissue development TAS10329008
    GO:0008285negative regulation of cell proliferation ISS--

    MYOG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MYOG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MYOG

    10/31 Novoseek inferred chemical compound relationships for MYOG gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 50.2 45 12783039 (3), 1658626 (2), 19573231 (2), 1312093 (1) (see all 38)
    ly294002 41.5 6 10896679 (1), 9790996 (1), 9849961 (1), 11861503 (1) (see all 6)
    acetylcholine 37.2 16 10095433 (2), 9593756 (2), 9836066 (2), 7969143 (1) (see all 13)
    c2ceramide 17.4 2 15256490 (1), 16777978 (1)
    ribonucleic acid 15.5 1 10951440 (1)
    bromodeoxyuridine 13.2 2 11900489 (1), 19515904 (1)
    retinoic acid 6.1 5 9218485 (1), 1341049 (1), 8194491 (1), 15674337 (1)
    butyrate 6.1 6 1328872 (3), 9218485 (1), 8806451 (1)
    estrogen 4.79 1 20123451 (1)
    glucose 2.64 4 8702591 (1), 9600108 (1), 9832443 (1)

    Search CenterWatch for drugs/clinical trials and news about MYOG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYOG gene: 
    NM_002479.5  

    Unigene Cluster for MYOG:

    Myogenin (myogenic factor 4)
    Hs.2830  [show with all ESTs]
    Unigene Representative Sequence: NM_002479
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000241651(uc001gzd.3)
    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate MYOG (see all 14):
    hsa-miR-579 hsa-miR-4324 hsa-miR-548p hsa-miR-328 hsa-miR-769-5p hsa-miR-548aa hsa-miR-664 hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidMYOG 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYOG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYOG

    Additional mRNA sequence: 

    BC053899.1 BT007233.1 X17651.1 

    2 DOTS entries:

    DT.92465213  DT.40106339 

    10 AceView cDNA sequences:

    NM_002479 BC053899 BT007233 X17651 AW469592 AI291603 BF306781 BQ952130 
    BE294922 BU189532 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYOG expression in normal human tissues (normalized intensities)      MYOG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGGTTAAC
    MYOG Expression
    About this image


    MYOG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 53 entries
             Mononuclear Myocytes Mandibular Arch Muscles
             Human Skeletal Muscle Satellite Cells (HSkMSC)   
     
     Somite (Muscoskeletal System)    fully expand to see all 33 entries
             Myoblasts Thoracic Primary Hypaxial Myotome
             mesenchyme/trunk mesenchyme/paraxial mesenchyme   
     
     Limb (Muscoskeletal System)    fully expand to see all 10 entries
             Myoblasts Forelimb Ventral Muscles
     
     Bone (Muscoskeletal System)
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
     
     Mesoderm (Gastrulation Derivatives)
             mesenchyme/trunk mesenchyme/body-wall mesenchyme   

    See MYOG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYOG

    SOURCE GeneReport for Unigene cluster: Hs.2830
        SABiosciences Expression via Pathway-Focused PCR Array including MYOG: 
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYOG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MYOG gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myog1 , 5 myogenin1, 5 90.62(n)1
    95.09(a)1
      1 (58.18 cM)5
    179281  NM_031189.21  NP_112466.11 
     1342900045 
    chicken
    (Gallus gallus)
    Aves MYOG1 myogenin (myogenic factor 4) 74.44(n)
    72.65(a)
      374004  NM_204184.1  NP_989515.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYOG6
    Uncharacterized protein
    60(a)
    1 ↔ 1
    4(133320820-133326597)
    African clawed frog
    (Xenopus laevis)
    Amphibia AY046532.12   -- 76.52(n)    AY046532.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myog2 myogenin 79.62(n)   30200  AF202639.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nau6
    nautilus
    21(a)
    1 → many
    3R(19538536-19544079)
    worm
    (Caenorhabditis elegans)
    Secernentea hlh-16
    Myoblast determination protein 1 homolog
    20(a)
    1 → many
    II(4518560-4522457)


    ENSEMBL Gene Tree for MYOG (if available)
    TreeFam Gene Tree for MYOG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYOG gene
    MYF52  MYOD12  MYF62  
    4 SIMAP similar genes for MYOG using alignment to 2 protein entries:     MYOG_HUMAN (see all proteins):
    MYF4    MYF5    MYF6    MYOD1

    MYOG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/173 SNPs in MYOG are shown (see all 173)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1885819401,2
    --203051758(+) GCTATC/TTGGCC 1 -- ds50010--------
    rs1420838601,2
    --203051775(+) GAAATG/TACAGT 1 -- ds50010--------
    rs1929494411,2
    --203051868(+) GGGAAA/TCCACA 1 -- ds50010--------
    rs120923911,2
    C--203051890(+) TGCACC/GTTGGC 1 -- ds50013Minor allele frequency- G:0.17NA WA 240
    rs1403972961,2
    --203052014(+) AGCCAA/GTTGTC 1 -- ds50010--------
    rs1847575801,2
    --203052024(+) CCTCCA/GTGTCC 1 -- ds50010--------
    rs618210921,2
    C,F--203052054(+) TCTGGT/GCTCCA 1 -- ds50012Minor allele frequency- G:0.17NA EA 240
    rs121427531,2
    C--203052177(+) ACCCAC/TTAGGG 1 -- ds50012Minor allele frequency- T:0.00NA 4
    rs1443273751,2
    C--203052247(+) CATCA-/CCCCCGAC 1 -- cds10--------
    rs1896285481,2
    --203052249(+) ATCACC/TGACAC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MYOG (203052257 - 203055377 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MYOG:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832370CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 159980    OMIM disorders: --

    20/41 diseases for MYOG (see all 41):    About MalaCards
    gallbladder sarcoma    undifferentiated embryonal sarcoma of the liver    melanotic neuroectodermal tumor    botryoid rhabdomyosarcoma
    tenosynovial giant cell tumor    pleomorphic rhabdomyosarcoma    embryonal rhabdomyosarcoma    desmoplastic small round cell tumor
    embryonal sarcoma    mesenchymal chondrosarcoma    fibrous histiocytoma    alveolar rhabdomyosarcoma
    alveolar soft part sarcoma    histiocytoma    sertoli-leydig cell tumor    giant cell tumor
    leiomyoma    cholera    leiomyosarcoma    soft tissue sarcoma

    6 diseases from the University of Copenhagen DISEASES database for MYOG:
    Rhabdomyosarcoma     Myopathy     Sarcoma     Leiomyosarcoma
    Neuropathy     Malignant mesenchymoma

    MYOG for disorders           About GeneDecksing

    10/30 Novoseek inferred disease relationships for MYOG gene (see all 30)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rhabdomyosarcoma 84.8 46 10095433 (4), 10666368 (4), 19372547 (3), 18493875 (3) (see all 26)
    rhabdomyosarcoma alveolar 80.4 8 10666368 (4), 18727437 (1), 18540440 (1), 18705836 (1)
    rhabdomyosarcoma embryonal 80.3 14 10666368 (5), 16945640 (2), 16010486 (1), 17549403 (1) (see all 7)
    myosarcoma 61.5 2 11473460 (1), 9796719 (1)
    ewings sarcoma 55.5 2 10227726 (1), 12426678 (1)
    leiomyosarcoma 53 3 11688574 (1), 10227726 (1), 11473460 (1)
    sarcoma 50.2 1 16785789 (1)
    myopathy, congenital 45.5 12 10329008 (3), 16977479 (2)
    hypertrophy 38.5 4 17395765 (2), 12716875 (1), 10370140 (1)
    malignant fibrous histiocytoma 37.2 1 11688574 (1)

    Genetic Association Database (GAD): MYOG
    Human Genome Epidemiology (HuGE) Navigator: MYOG (2 documents)

    Export disorders for MYOG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYOG gene, integrated from 9 sources (see all 491):
    (articles sorted by number of sources associating them with MYOG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcription of the muscle regulatory gene Myf4 is regulated by serum components, peptide growth factors and signaling pathways involving G proteins. (PubMed id 1659574)1, 2, 9 Salminen A....Arnold H.H. (1991)
    2. Human bHLH transcription factor gene myogenin (MYOG): genomic sequence and negative mutation analysis in patients with severe congenital myopathies. (PubMed id 10329008)1, 3, 9 Tseng B.S.... Butler I.J. (1999)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products. (PubMed id 2583111)1, 2 Braun T....Arnold H.H. (1989)
    6. Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization. (PubMed id 2163343)1, 9 Brennan T.J. and Olson E.N. (1990)
    7. [Correlation between myogenin and transforming growth factor-beta1 expression in long-term human denervated posterior cricoarytenoid muscles] (PubMed id 19961777)1, 9 Zhang X....Chen S.C. (2009)
    8. Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis. (PubMed id 18676376)1, 9 Armand A.S....De Windt L.J. (2008)
    9. Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiation. (PubMed id 15084602)1, 9 Konig S....Bernheim L. (2004)
    10. Effects of one bout of endurance exercise on the expression of myogenin in human quadriceps muscle. (PubMed id 14997318)1, 9 Kadi F....Henriksson J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4656 HGNC: 7612 AceView: MYOG Ensembl:ENSG00000122180 euGenes: HUgn4656
    ECgene: MYOG H-InvDB: MYOG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYOG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYOG gene:
    Search GeneIP for patents involving MYOG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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