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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYOG Gene

protein-coding   GIFtS: 62
GCID: GC01M203052

myogenin (myogenic factor 4)


(Previous symbol: MYF4)
 Explore 40 diseases affiliated with
MYOG via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MYOG    

Aliases
for MYOG gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Myogenin (Myogenic Factor 4)1 2     Myf-43
MYF41 2 3 5     Myogenin1
BHLHc31     BHLHC33
Class C Basic Helix-Loop-Helix Protein 32 3     Myf-43
Myogenic Factor 42 3     

External Ids:    HGNC: 76121   Entrez Gene: 46562   Ensembl: ENSG000001221807   OMIM: 1599805   UniProtKB: P151733   

Export aliases for MYOG gene to outside databases

Previous GC identifers: GC01M200735 GC01M198482 GC01M199518 GC01M200340 GC01M199783 GC01M201318 GC01M174217


Summaries
for MYOG gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MYOG:
Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue
culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH)
proteins. It is essential for the development of functional skeletal muscle. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MYOG_HUMAN, P15173
Function: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts.
Probable sequence specific DNA-binding protein

Gene Wiki entry for MYOG (Myogenin)


Genomic Views
for MYOG gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYOG gene promoter:
         AP-2alpha isoform 3   p53   AML1a   MyoD   AP-2alpha isoform 2   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYOG promoter sequence
   Search SABiosciences Chromatin IP Primers for MYOG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYOG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31-q41   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q31-q41

MYOG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYOG gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M203052:  view genomic region     (about GC identifiers)

Start:
 203,052,257 bp from pter      End:
 203,055,377 bp from pter
Size:
 3,121 bases      Orientation:
 minus strand

Proteins
for MYOG gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MYOG_HUMAN, P15173 (See protein sequence)
Recommended Name: Myogenin  
Size: 224 amino acids; 25037 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein
Subcellular location: Nucleus
Secondary accessions: Q53XW6

Explore the universe of human proteins at neXtProt for MYOG: NX_P15173

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P15173

    • MYOG Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002470.2  
    ENSEMBL proteins: 
     ENSP00000241651  
    Reactome Protein details: P15173
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: MYOG
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    Novus Biologicals MYOG Protein
    Novus Biologicals MYOG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MYOG

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex ISS--


    MYOG for ontologies           About GeneDecksing



    MYOG Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MYOG
    R&D Systems Antibodies for MYOG (Myogenin)
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    ThermoFisher Antibody for MYOG

    Assay Products for MYOG: 
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    Uscn ELISAs and CLIAs for MYOG

    Protein Domains /
    Families
    for MYOG gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MYOG for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002546 Basic
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry P15173

    ProtoNet protein and cluster: P15173

    2 Blocks protein families:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB002546 Myogenic basic muscle-specific protein


    UniProtKB/Swiss-Prot: MYOG_HUMAN, P15173
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Function
    for MYOG gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MYOG_HUMAN, P15173
    Function: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts.
    Probable sequence specific DNA-binding protein

         Genatlas biochemistry entry for MYOG:
    myogenic factor 4,transcription activator (myogenin),required for the differentiation of skeletal muscle

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYOG
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate MYOG (see all 14):
    hsa-miR-579 hsa-miR-4324 hsa-miR-548p hsa-miR-328 hsa-miR-769-5p hsa-miR-548aa hsa-miR-664 hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmid: MYOG 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYOG (see all 7)
    OriGene shRNA RFP: MYOG
    OriGene siRNA: MYOG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYOG

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MYOG

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYOG (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYOG
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    GenScript: all cDNA clones in your preferred vector: MYOG (NM_002479)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYOG 

    Cell Line
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    Search LifeMap BioReagents cell lines for MYOG

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOG

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding ISS--
    GO:0000987core promoter proximal region sequence-specific DNA binding IEA--
    GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription TAS19783823
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS1850513


    MYOG for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for MYOG: Myogtm1Yin Myogtm1Whk
         11 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Myog):
     adipose tissue  behavior/neurological  embryogenesis  growth/size  homeostasis/metabolism 
     integument  mortality/aging  muscle  normal  respiratory system 
     skeleton 

    MYOG for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MYOG gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    		Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis1.00
    		Development_Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis0.97
    2Activation of p38 alpha/beta MAPK
    		CDO in myogenesis0.55
    		Myogenesis0.55
    3Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    		Regulation of Wnt-mediated beta catenin signaling and target gene transcription1.00
    4Id Signaling Pathway
    		Id Signaling Pathway1.00
    5Axon guidance
    		Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MYOG
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis


    1 GeneGo (Thomson Reuters) Pathway for MYOG
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

    2 BioSystems Pathways for MYOG 
        Id Signaling Pathway
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    3        Reactome Pathways for MYOG
        Developmental Biology
    Myogenesis
    CDO in myogenesis



    MYOG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYOG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for MYOG (P151732, 3 ENSP000002416514) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRFP118312, 3, ENSP000002653544MINT-16345 MINT-16346 I2D: score=4 STRING: ENSP00000265354
    CALM1P621583, ENSP000003494674I2D: score=6 STRING: ENSP00000349467
    CALM2P621583I2D: score=6 
    CALM3P621583I2D: score=6 
    POLR2CP193873, ENSP000002192524I2D: score=3 STRING: ENSP00000219252
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007517muscle organ development ----
    GO:0007519skeletal muscle tissue development TAS10329008
    GO:0042692muscle cell differentiation TAS--


    MYOG for ontologies           About GeneDecksing



    Drugs & Compounds
    for MYOG gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MYOG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MYOG
    10/31 Novoseek chemical compound relationships for MYOG gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 50.2 45 12783039 (3), 1658626 (2), 19573231 (2), 1312093 (1) (see all 38)
    ly294002 41.5 6 10896679 (1), 9790996 (1), 9849961 (1), 11861503 (1) (see all 6)
    acetylcholine 37.2 16 10095433 (2), 9593756 (2), 9836066 (2), 7969143 (1) (see all 13)
    c2ceramide 17.4 2 15256490 (1), 16777978 (1)
    ribonucleic acid 15.5 1 10951440 (1)
    bromodeoxyuridine 13.2 2 11900489 (1), 19515904 (1)
    retinoic acid 6.1 5 9218485 (1), 1341049 (1), 8194491 (1), 15674337 (1)
    butyrate 6.1 6 1328872 (3), 9218485 (1), 8806451 (1)
    estrogen 4.79 1 20123451 (1)
    glucose 2.64 4 8702591 (1), 9600108 (1), 9832443 (1)

    Search CenterWatch for drugs/clinical trials and news about MYOG 

    Transcripts
    for MYOG gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MYOG gene: 
    NM_002479.5  

    Unigene Cluster for MYOG:

    Myogenin (myogenic factor 4)
    Hs.2830  [show with all ESTs]
    Unigene Representative Sequence: NM_002479
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000241651(uc001gzd.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYOG
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate MYOG (see all 14):
    hsa-miR-579 hsa-miR-4324 hsa-miR-548p hsa-miR-328 hsa-miR-769-5p hsa-miR-548aa hsa-miR-664 hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmid: MYOG 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYOG (see all 7)
    OriGene shRNA RFP: MYOG
    OriGene siRNA: MYOG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYOG
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MYOG (NM_002479)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYOG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYOG

    Additional cDNA sequence: 

    BC053899.1 BT007233.1 X17651.1 

    2 DOTS entries:

    DT.92465213  DT.40106339 

    10 AceView cDNA sequences:

    NM_002479 BC053899 BT007233 X17651 AW469592 AI291603 BF306781 BQ952130 
    BE294922 BU189532 

    GeneLoc Exon Structure


    Expression
    for MYOG gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYOG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAGGTTAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MYOG expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/52 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 52) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb Dorsal MusclesMononuclear MyocytesSkeletal Muscle
    LimbForelimb Dorsal MusclesMyoblastsSkeletal Muscle
    LimbForelimb Ventral MusclesMononuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMyoblastsSkeletal Muscle
    LimbHindlimb Dorsal MuscleMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMyoblastsSkeletal Muscle
    LimbHindlimb Ventral MuscleMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMyoblastsSkeletal Muscle
    Skeletal MuscleExtraocular MusclesMultinuclear MyocyteSkeletal Muscle
    Skeletal MuscleExtraocular MusclesMyoblastsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    Skeletal muscle-like cells (Generation of skelet...)
    Expanded PAX7 cells (Generation of skelet...)
    Myotubes (Generation of skelet...)
    Skeletal myocytes (Generation of skelet...)
    Skeletal myocytes (Generation of skelet...)

    See MYOG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYOG

    SOURCE GeneReport for Unigene cluster: Hs.2830
        SABiosciences Expression via Pathway-Focused PCR Array including MYOG: 
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOG

    Orthologs
    for MYOG gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MYOG gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MYOG1 myogenin (myogenic factor 4) 74.44(n)
    72.65(a)    		   374004  NM_204184.1  NP_989515.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MYOG6
    		 --
    		 66(a)
    		 1 ↔ 1
    		 4(133321050-133325750)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AY046532.12   -- 76.52(n)    AY046532.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii myog2 myogenin 79.62(n)   30200  AF202639.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta nau6
    		 nautilus
    		 21(a)
    		 1 → many
    		 3R(19538536-19544079)
    worm
    (Caenorhabditis elegans)    		 Secernentea hlh-16
    		 Myoblast determination protein 1 homolog
    		 20(a)
    		 1 → many
    		 II(4518557-4522454)


    ENSEMBL Gene Tree for MYOG (if available)
    TreeFam Gene Tree for MYOG (if available) 

    Paralogs
    for MYOG gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYOG gene
    MYF52  MYOD12  MYF62  
    4 SIMAP similar genes for MYOG using alignment to 2 protein entries:     MYOG_HUMAN (see all proteins):
    MYF4    MYF5    MYF6    MYOD1

    MYOG for paralogs           About GeneDecksing



    Genomic Variants
    for MYOG gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/143 NCBI SNPs in MYOG are shown (see all 143)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1885819401,2
    		--203051758(+) GCTATC/TTGGCC 1 -- ds50010--------
    rs1420838601,2
    		--203051775(+) GAAATG/TACAGT 1 -- ds50010--------
    rs1929494411,2
    		--203051868(+) GGGAAA/TCCACA 1 -- ds50010--------
    rs120923911,2
    		C,--203051890(+) TGCACC/GTTGGC 1 -- ds50013Minor allele frequency- G:0.17NA WA 240
    rs1403972961,2
    		--203052014(+) AGCCAA/GTTGTC 1 -- ds50010--------
    rs1847575801,2
    		--203052024(+) CCTCCA/GTGTCC 1 -- ds50010--------
    rs618210921,2
    		C,F,--203052054(+) TCTGGT/GCTCCA 1 -- ds50012Minor allele frequency- G:0.17NA EA 240
    rs121427531,2
    		C--203052177(+) ACCCAC/TTAGGG 1 -- ds50012Minor allele frequency- T:0.00NA 4
    rs1443273751,2
    		--203052246(+) CATCA-/CCCCCGAC 1 -- ds50010--------
    rs1896285481,2
    		--203052249(+) ATCACC/TGACAC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MYOG (203052257 - 203055377 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MYOG: --

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    Disorders / Diseases
    for MYOG gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MYOG for disorders           About GeneDecksing

    OMIM gene information: 159980    OMIM disorders: --

    20/40 diseases for MYOG (see all 40):    About MalaCards
    desmoplastic small round cell tumor    alveolar soft part sarcoma    malignant fibrous histiocytoma    sertoli-leydig cell tumor
    fibrous histiocytoma    tenosynovial giant cell tumor    melanotic neuroectodermal tumor    leydig cell tumor
    botryoid rhabdomyosarcoma    myotonic dystrophy    giant cell tumor    rhabdomyosarcoma
    soft tissue sarcoma    mesenchymal chondrosarcoma    histiocytoma    chronic obstructive pulmonary disease
    alveolar rhabdomyosarcoma    neuroectodermal tumors    pleomorphic rhabdomyosarcoma    wilms tumor

    5 diseases from the University of Copenhagen DISEASES database for MYOG:
    Rhabdomyosarcoma     Myopathy     Sarcoma     Neuropathy
    Leiomyosarcoma

    10/30 Novoseek disease relationships for MYOG gene (see all 30)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rhabdomyosarcoma 84.8 46 10095433 (4), 10666368 (4), 19372547 (3), 18493875 (3) (see all 26)
    rhabdomyosarcoma alveolar 80.4 8 10666368 (4), 18727437 (1), 18540440 (1), 18705836 (1)
    rhabdomyosarcoma embryonal 80.3 14 10666368 (5), 16945640 (2), 16010486 (1), 17549403 (1) (see all 7)
    myosarcoma 61.5 2 11473460 (1), 9796719 (1)
    ewings sarcoma 55.5 2 10227726 (1), 12426678 (1)
    leiomyosarcoma 53 3 11688574 (1), 10227726 (1), 11473460 (1)
    sarcoma 50.2 1 16785789 (1)
    myopathy, congenital 45.5 12 10329008 (3), 16977479 (2)
    hypertrophy 38.5 4 17395765 (2), 12716875 (1), 10370140 (1)
    malignant fibrous histiocytoma 37.2 1 11688574 (1)

    Human Genome Epidemiology (HuGE) Navigator: MYOG (2 documents)

    Export disorders for MYOG gene to outside databases

    Publications
    for MYOG gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYOG gene, integrated from 9 sources (see all 488):
    (articles sorted by number of sources associating them with MYOG)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcription of the muscle regulatory gene Myf4 is regulated by serum components, peptide growth factors and signaling pathways involving G proteins. (PubMed id 1659574)1, 2, 9 Salminen A....Arnold H.H. (1991)
    2. Human bHLH transcription factor gene myogenin (MYOG): genomic sequence and negative mutation analysis in patients with severe congenital myopathies. (PubMed id 10329008)1, 3, 9 Tseng B.S.... Butler I.J. (1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products. (PubMed id 2583111)1, 2 Braun T....Arnold H.H. (1989)
    5. Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization. (PubMed id 2163343)1, 9 Brennan T.J. and Olson E.N. (1990)
    6. [Correlation between myogenin and transforming growth factor-beta1 expression in long-term human denervated posterior cricoarytenoid muscles] (PubMed id 19961777)1, 9 Zhang X....Chen S.C. (2009)
    7. Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis. (PubMed id 18676376)1, 9 Armand A.S....De Windt L.J. (2008)
    8. Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiation. (PubMed id 15084602)1, 9 Konig S....Bernheim L. (2004)
    9. Effects of one bout of endurance exercise on the expression of myogenin in human quadriceps muscle. (PubMed id 14997318)1, 9 Kadi F....Henriksson J. (2004)
    10. Cyclic amplification and selection of targets for multicomponent complexes: myogenin interacts with factors recognizing binding sites for basic helix-loop-helix, nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor. (PubMed id 1329097)1, 9 Funk W.D. and Wright W.E. (1992)

    External Searches for MYOG gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing MYOG gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4656 HGNC: 7612 AceView: MYOG Ensembl:ENSG00000122180 euGenes: HUgn4656
    ECgene: MYOG H-InvDB: MYOG

    Other Databases showing MYOG gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MYOG gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYOG Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MYOG gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MYOG gene:
    Search GeneIP for patents involving MYOG

    GeneCards and IP:
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