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Aliases for MYOG Gene

Aliases for MYOG Gene

  • Myogenin (Myogenic Factor 4) 2 3
  • Class C Basic Helix-Loop-Helix Protein 3 3 4
  • Myogenic Factor 4 3 4
  • Myogenin 3 6
  • BHLHc3 3 4
  • Myf-4 3 4
  • MYF4 3 4

External Ids for MYOG Gene

Previous HGNC Symbols for MYOG Gene

  • MYF4

Previous GeneCards Identifiers for MYOG Gene

  • GC01M200735
  • GC01M198482
  • GC01M199518
  • GC01M200340
  • GC01M199783
  • GC01M201318
  • GC01M174217

Summaries for MYOG Gene

Entrez Gene Summary for MYOG Gene

  • Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYOG Gene

MYOG (Myogenin (Myogenic Factor 4)) is a Protein Coding gene. Diseases associated with MYOG include malignant mesenchymoma and gallbladder sarcoma. Among its related pathways are L1CAM interactions and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and E-box binding. An important paralog of this gene is MYOD1.

UniProtKB/Swiss-Prot for MYOG Gene

  • Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity).

Gene Wiki entry for MYOG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYOG Gene

Genomics for MYOG Gene

Regulatory Elements for MYOG Gene

Genomic Location for MYOG Gene

Start:
203,083,129 bp from pter
End:
203,086,038 bp from pter
Size:
2,910 bases
Orientation:
Minus strand

Genomic View for MYOG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYOG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYOG Gene

Proteins for MYOG Gene

  • Protein details for MYOG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15173-MYOG_HUMAN
    Recommended name:
    Myogenin
    Protein Accession:
    P15173
    Secondary Accessions:
    • Q53XW6

    Protein attributes for MYOG Gene

    Size:
    224 amino acids
    Molecular mass:
    25037 Da
    Quaternary structure:
    • Homodimer and heterodimer with E12; heterodimerization enhances MYOG DNA-binding and transcriptional activities. Interacts with SMARCA4/BRG1/BAF190A. Interacts (via C-terminal region) with SSRP1 and SUPT16H; the interaction is indicative of an interaction with the FACT complex (By similarity).

neXtProt entry for MYOG Gene

Proteomics data for MYOG Gene at MOPED

Post-translational modifications for MYOG Gene

  • Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner. Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYOG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MYOG Gene

Domains for MYOG Gene

Gene Families for MYOG Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Suggested Antigen Peptide Sequences for MYOG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15173

UniProtKB/Swiss-Prot:

MYOG_HUMAN :
  • P15173
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with MYOG: view

Function for MYOG Gene

Molecular function for MYOG Gene

GENATLAS Biochemistry:
myogenic factor 4,transcription activator (myogenin),required for the differentiation of skeletal muscle
UniProtKB/Swiss-Prot Function:
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity).

Gene Ontology (GO) - Molecular Function for MYOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISS --
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0000987 core promoter proximal region sequence-specific DNA binding --
GO:0001047 core promoter binding ISS --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
genes like me logo Genes that share ontologies with MYOG: view
genes like me logo Genes that share phenotypes with MYOG: view

Animal Models for MYOG Gene

MGI Knock Outs for MYOG:

miRNA for MYOG Gene

miRTarBase miRNAs that target MYOG
Targeting motifs for MYOG Gene
HOMER Transcription Factor Regulatory Elements motif MYOG
  • Consensus sequence: AACAGCTG Submotif: canonical Cell Type: C2C12 GeoId: GSE36024

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for MYOG Gene

Localization for MYOG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYOG Gene

Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription initiation in developing embryos. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYOG Gene COMPARTMENTS Subcellular localization image for MYOG gene
Compartment Confidence
nucleus 5
cytoskeleton 3
extracellular 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MYOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex ISS --
GO:0032993 protein-DNA complex ISS --
genes like me logo Genes that share ontologies with MYOG: view

Pathways for MYOG Gene

genes like me logo Genes that share pathways with MYOG: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MYOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007049 cell cycle IEA --
GO:0007517 muscle organ development --
GO:0007519 skeletal muscle tissue development TAS 10329008
genes like me logo Genes that share ontologies with MYOG: view

Compounds for MYOG Gene

(31) Novoseek inferred chemical compound relationships for MYOG Gene

Compound -log(P) Hits PubMed IDs
creatinine 50.2 42
ly294002 41.5 6
acetylcholine 37.2 16
c2ceramide 17.4 2
ribonucleic acid 15.5 1
genes like me logo Genes that share compounds with MYOG: view

Transcripts for MYOG Gene

mRNA/cDNA for MYOG Gene

(10) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYOG Gene

Myogenin (myogenic factor 4):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYOG

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYOG Gene

No ASD Table

Relevant External Links for MYOG Gene

GeneLoc Exon Structure for
MYOG
ECgene alternative splicing isoforms for
MYOG

Expression for MYOG Gene

mRNA expression in normal human tissues for MYOG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYOG Gene

This gene is overexpressed in Muscle - Skeletal (49.4).

SOURCE GeneReport for Unigene cluster for MYOG Gene Hs.2830

genes like me logo Genes that share expressions with MYOG: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MYOG Gene

Orthologs for MYOG Gene

This gene was present in the common ancestor of animals.

Orthologs for MYOG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYOG 35
  • 90.48 (n)
  • 93.3 (a)
MYOG 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYOG 35
  • 89.88 (n)
  • 92.86 (a)
MYOG 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myog 35
  • 90.62 (n)
  • 95.09 (a)
Myog 16
Myog 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myog 35
  • 90.77 (n)
  • 94.2 (a)
oppossum
(Monodelphis domestica)
Mammalia MYOG 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYOG 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYOG 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYOG 35
  • 74.44 (n)
  • 72.65 (a)
MYOG 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYOG 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myog 35
  • 60.76 (n)
  • 64.09 (a)
Str.11193 35
zebrafish
(Danio rerio)
Actinopterygii myog 35
  • 64.21 (n)
  • 62.21 (a)
myog 36
  • 50 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11695 35
fruit fly
(Drosophila melanogaster)
Insecta nau 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hlh-1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 14 (a)
OneToMany
Species with no ortholog for MYOG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYOG Gene

ENSEMBL:
Gene Tree for MYOG (if available)
TreeFam:
Gene Tree for MYOG (if available)

Paralogs for MYOG Gene

Paralogs for MYOG Gene

Selected SIMAP similar genes for MYOG Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MYOG: view

Variants for MYOG Gene

Sequence variations from dbSNP and Humsavar for MYOG Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs903356 -- 203,084,640(-) TAAGT(A/G)AGGCC intron-variant
rs923950 -- 203,085,395(-) GTTGG(A/T)GCAGG intron-variant
rs1532324 -- 203,087,375(-) TGACG(C/T)GAGCA upstream-variant-2KB
rs2071452 -- 203,083,721(-) TGGAC(A/G)CCCTC utr-variant-3-prime
rs3737876 -- 203,086,260(-) TGAAA(A/G)CTAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MYOG Gene

Variant ID Type Subtype PubMed ID
nsv832370 CNV Loss 17160897

Relevant External Links for MYOG Gene

HapMap Linkage Disequilibrium report
MYOG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYOG Gene

Disorders for MYOG Gene

(6) University of Copenhagen DISEASES for MYOG Gene

(30) Novoseek inferred disease relationships for MYOG Gene

Disease -log(P) Hits PubMed IDs
rhabdomyosarcoma 84.8 42
rhabdomyosarcoma alveolar 80.4 7
rhabdomyosarcoma embryonal 80.3 12
myosarcoma 61.5 2
ewings sarcoma 55.5 2

Relevant External Links for MYOG

Genetic Association Database (GAD)
MYOG
Human Genome Epidemiology (HuGE) Navigator
MYOG
genes like me logo Genes that share disorders with MYOG: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for MYOG Gene

Publications for MYOG Gene

  1. Human bHLH transcription factor gene myogenin (MYOG): genomic sequence and negative mutation analysis in patients with severe congenital myopathies. (PMID: 10329008) Tseng B.S. … Butler I.J. (Genomics 1999) 2 3 23
  2. Transcription of the muscle regulatory gene Myf4 is regulated by serum components, peptide growth factors and signaling pathways involving G proteins. (PMID: 1659574) Salminen A. … Arnold H.H. (J. Cell Biol. 1991) 3 4 23
  3. Cyclic amplification and selection of targets for multicomponent complexes: myogenin interacts with factors recognizing binding sites for basic helix-loop-helix, nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor. (PMID: 1329097) Funk W.D. … Wright W.E. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 23
  4. Resistance exercise alters MRF and IGF-I mRNA content in human skeletal muscle. (PMID: 12716875) Psilander N. … Pilegaard H. (J. Appl. Physiol. 2003) 3 23
  5. Effects of one bout of endurance exercise on the expression of myogenin in human quadriceps muscle. (PMID: 14997318) Kadi F. … Henriksson J. (Histochem. Cell Biol. 2004) 3 23

Products for MYOG Gene

Sources for MYOG Gene

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