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MYOD1 Gene

protein-coding   GIFtS: 66
GCID: GC11P017741

Myogenic Differentiation 1

(Previous name: myogenic factor 3)
(Previous symbol: MYF3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myogenic Differentiation 11 2     bHLHc12 3
MYF31 2 3 5     PUM2
Myogenic Factor 31 2 3     myf-32
Myoblast Determination Protein 11 2     BHLHC13
Class C Basic Helix-Loop-Helix Protein 12 3     Myf-33
MYOD2 3     

External Ids:    HGNC: 76111   Entrez Gene: 46542   Ensembl: ENSG000001291527   OMIM: 1599705   UniProtKB: P151723   

Export aliases for MYOD1 gene to outside databases

Previous GC identifers: GC11P018862 GC11P018683 GC11P017780 GC11P017705 GC11P017697 GC11P017425


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYOD1 Gene:
This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and
the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a
prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own
transcription which may stabilize commitment to myogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for MYOD1 Gene:
MYOD1 (myogenic differentiation 1) is a protein-coding gene. Diseases associated with MYOD1 include ectomesenchymoma, and malignant fibrous histiocytoma of bone. GO annotations related to this gene include transcription coactivator activity and protein heterodimerization activity. An important paralog of this gene is MYF5.

UniProtKB/Swiss-Prot: MYOD1_HUMAN, P15172
Function: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and
plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter
core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is
inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By
similarity)

Gene Wiki entry for MYOD1 (MyoD) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYOD1 gene promoter:
         PPAR-gamma1   p300   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYOD1 promoter sequence
   Search Chromatin IP Primers for MYOD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYOD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15

MYOD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYOD1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P017741:  view genomic region     (about GC identifiers)

Start:
17,741,110 bp from pter      End:
17,743,678 bp from pter
Size:
2,569 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MYOD1_HUMAN, P15172 (See protein sequence)
Recommended Name: Myoblast determination protein 1  
Size: 320 amino acids; 34501 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers
with ITF-2. Interacts with SUV39H1 and CDK9. Interacts with DDX5. Interacts with CHD2 (By similarity)
Secondary accessions: O75321

Explore the universe of human proteins at neXtProt for MYOD1: NX_P15172

Explore proteomics data for MYOD1 at MOPED

Post-translational modifications: 

  • Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation1
  • Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes.
    Conversely, its deacetylation by SIRT1 inhibits its function (By similarity)1
  • Ubiquitinated on the N-terminus; which is required for proteasomal degradation1
  • Methylation at Lys-104 by EHMT2/G9a inhibits myogenic activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYOD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002469.2  
    ENSEMBL proteins: 
     ENSP00000250003  
    Reactome Protein details: P15172

    MYOD1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for MYOD1
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    Novus Biologicals MYOD1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    MYOD1 Antibody Products:

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    R&D Systems Antibodies for MYOD1 (MyoD)
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    LSBio Antibodies in human, mouse, rat for MYOD1

    MYOD1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MYOD1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    3 InterPro protein domains:
     IPR022032 Myf5
     IPR002546 Basic
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry P15172

    ProtoNet protein and cluster: P15172

    2 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB002546 Myogenic basic muscle-specific protein


    UniProtKB/Swiss-Prot: MYOD1_HUMAN, P15172
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    MYOD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYOD1_HUMAN, P15172
    Function: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and
    plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter
    core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is
    inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By
    similarity)

         Genatlas biochemistry entry for MYOD1:
    myogenic differentiation 1,transcription activator of muscle specific genes,promoting cell cycle exit by inducing
    CDKNIA

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001047core promoter binding ISS--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity TAS1846704
    GO:0003713transcription coactivator activity TAS1846704
         
    MYOD1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MYOD1:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         12 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Myod1):
     adipose tissue  cardiovascular system  growth/size/body  homeostasis/metabolism  mortality/aging 
     muscle  no phenotypic analysis  normal  reproductive system  respiratory system 
     skeleton  tumorigenesis 

    MYOD1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MYOD1: Myod1tm1.1Glh Myod1tm1Glh Myod1tm1Jae Myod1tm2Glh Myod1tm2.1Glh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYOD1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYOD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYOD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYOD1

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for MYOD1 (see all 1228):
    AAAS,  AAMP,  ABCB6,  ABCF2,  ABL1,  ABO,  ACAT2,  ACN9,  ACOT8,  ACRBP

    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  AGCAGCTGCTGC 

    miRNA
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    miRTarBase miRNAs that target MYOD1:
    hsa-mir-335-5p (MIRT019143), hsa-mir-324-5p (MIRT043226)

    Block miRNA regulation of human, mouse, rat MYOD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYOD1 (see all 16):
    hsa-miR-3128 hsa-miR-520d-5p hsa-miR-548l hsa-miR-330-3p hsa-miR-518c hsa-miR-518f hsa-miR-4283 hsa-miR-577
    SwitchGear 3'UTR luciferase reporter plasmidMYOD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MYOD1
    Predesigned siRNA for gene silencing in human, mouse, rat MYOD1

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYOD1 (NM_002478)
    Sino Biological Human cDNA Clone for MYOD1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYOD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYOD1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MYOD1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYOD1_HUMAN, P15172: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton3
    extracellular2
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin ISS--
    GO:0005634nucleus TAS3175662
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex ISS--
    GO:0005737cytoplasm ----

    MYOD1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYOD1 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1CDO in myogenesis
    CDO in myogenesis1.00
    Myogenesis1.00
    2L1CAM interactions
    Developmental Biology0.63
    3Development NOTCH1 mediated pathway for NF KB activity modulation
    Development Notch Signaling Pathway0.50
    4Immune response Function of MEF2 in T lymphocytes
    Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis0.38
    5TGF-beta Signaling Pathways
    TGF-beta Signaling Pathways

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for MYOD1
        TGF-beta Signaling Pathways


    2 GeneGo (Thomson Reuters) Pathways for MYOD1
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Development Notch Signaling Pathway

    Selected BioSystems Pathways for MYOD1 (see all 7)
        Id Signaling Pathway
    Regulation of nuclear SMAD2/3 signaling
    Signaling events mediated by HDAC Class III
    C-MYB transcription factor network
    Regulation of retinoblastoma protein


    1 Reactome Pathway for MYOD1
        CDO in myogenesis



    MYOD1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MYOD1 (see all 10): 
              Terminal Differentiation Markers in human mouse rat
              Lymphoma in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Stem Cells in human mouse rat
              Cell Lineage Identification in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MYOD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYOD1 (P151721, 2, 3 ENSP000002500034) via UniProtKB, MINT, STRING, and/or I2D (see all 150)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000381regulation of alternative mRNA splicing, via spliceosome IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS1846704
    GO:0006366transcription from RNA polymerase II promoter TAS1846704
    GO:0006468protein phosphorylation TAS3175662

    MYOD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYOD1

    Selected Novoseek inferred chemical compound relationships for MYOD1 gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 37.7 24 9268344 (1), 17942416 (1), 1847137 (1), 12196028 (1) (see all 21)
    retinoic acid 31.7 18 1520304 (4), 11024001 (4), 19757389 (1), 14623241 (1) (see all 9)
    chlorate 31.5 1 11784020 (1)
    lactacystin 28.8 1 9917519 (1)
    bromodeoxyuridine 25.7 1 16750930 (1)
    acetylcholine 17.9 8 8393291 (1), 14662021 (1), 18293705 (1), 8383334 (1) (see all 6)
    mg 132 17 1 10942602 (1)
    threonine 16.5 4 9804168 (1), 1651276 (1), 9418854 (1)
    leucine 11.4 1 1310896 (1)
    chloramphenicol 7.84 1 8336713 (1)



    MYOD1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MYOD1 gene: 
    NM_002478.4  

    Unigene Cluster for MYOD1:

    Myogenic differentiation 1
    Hs.181768  [show with all ESTs]
    Unigene Representative Sequence: NM_002478
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000250003(uc001mni.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MYOD1 (see all 16):
    hsa-miR-3128 hsa-miR-520d-5p hsa-miR-548l hsa-miR-330-3p hsa-miR-518c hsa-miR-518f hsa-miR-4283 hsa-miR-577
    SwitchGear 3'UTR luciferase reporter plasmidMYOD1 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat MYOD1

    Additional mRNA sequence: 

    AK314968.1 BC064493.1 BT007157.1 X17650.1 X56677.1 

    4 DOTS entries:

    DT.100828831  DT.95218213  DT.86848246  DT.91770652 

    Selected AceView cDNA sequences (see all 86):

    CR612159 NM_002478 BC064493 AI300241 BE296570 BI115390 BT007157 BG827263 
    BE250705 BF309465 BE297743 BF205042 BE019102 BU738397 BE299732 BF309452 
    BF309303 BE019098 BI114827 BE298779 BE019350 BG825891 BF204180 BE299768 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYOD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTGTGGTG
    MYOD1 Expression
    About this image


    MYOD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 69 entries
             Multinuclear Myocyte Extraocular Muscles
             Myogenic cells
             cavities and their linings/intraembryonic coelom/diaphragm   
     
     Somite (Muscoskeletal System)    fully expand to see all 36 entries
             Myoblasts Cervical Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 14 entries
             Myoblasts Forelimb Ventral Muscles
             Stylopod
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Hypobranchial Muscles
     
     NULL (Uncategorized)    fully expand to see all 5 entries
             Cardiomyocyte-like cells
    MYOD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYOD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.181768
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MYOD1 (see all 10): 
              Terminal Differentiation Markers in human mouse rat
              Lymphoma in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Stem Cells in human mouse rat
              Cell Lineage Identification in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for MYOD1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYOD1
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    QuantiFast Probe-based Assays in human, mouse, rat MYOD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MYOD1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myod11 , 5 myogenic differentiation 11, 5 84.49(n)1
    87.74(a)1
      7 (30.03 cM)5
    179271  NM_010866.21  NP_034996.21 
     463764745 
    chicken
    (Gallus gallus)
    Aves MYOD11 myogenic differentiation 1 72.05(n)
    68.73(a)
      374048  NM_204214.1  NP_989545.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYOD16
    myogenic differentiation 1
    69(a)
    1 ↔ 1
    1(67298921-67311593)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia myod11 myogenic differentiation 1 70.77(n)
    72.89(a)
      394569  NM_203641.1  NP_988972.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myod11 myogenic differentiation 1 66.29(n)
    69.58(a)
      30513  NM_131262.2  NP_571337.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta nau6
    nautilus
    30(a)
    1 → many
    3R(19538536-19544079)
    worm
    (Caenorhabditis elegans)
    Secernentea hlh-16
    Protein HLH-1, isoform b
    24(a)
    1 → many
    II(4518560-4522457) WBGene00001948


    ENSEMBL Gene Tree for MYOD1 (if available)
    TreeFam Gene Tree for MYOD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYOD1 gene
    MYF52  MYOG2  MYF62  
    2 SIMAP similar genes for MYOD1 using alignment to 1 protein entry:     MYOD1_HUMAN:
    MYF5    MYOG

    MYOD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYOD1 (see all 121)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363924
    A breast cancer sample4--see VAR_0363922 E K mis40--------
    VAR_0363934
    A breast cancer sample4--see VAR_0363932 A V mis40--------
    rs1465188941,2
    --17739177(+) AGTCTA/TGGTTT 1 -- us2k10--------
    rs570097111,2
    C--17739201(+) AGCCCC/AACACT 1 -- us2k12Minor allele frequency- A:0.14WA 120
    rs728678621,2
    C--17739255(+) ATTTCC/TGGGTG 1 -- us2k10--------
    rs27345561,2
    H--17739302(+) TGCTGC/GCTCTG 1 -- us2k14Minor allele frequency- G:0.00NS EA 412
    rs1806963751,2
    --17739404(+) GAGTAC/GTTCAT 1 -- us2k10--------
    rs747079521,2
    C,F--17739463(+) TAGGAC/TCCCAA 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs599390091,2
    C,F--17739550(+) TAGTGG/AGAAAG 1 -- us2k12Minor allele frequency- A:0.03WA 120
    rs766240751,2
    F--17739661(+) CTGTGT/CGAACT 1 -- us2k11Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for MYOD1 (17741110 - 17743678 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MYOD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv825772CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYOD1
    DNA2.0 Custom Variant and Variant Library Synthesis for MYOD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 159970    OMIM disorders: --

    Selected diseases for MYOD1 (see all 48):    
    About MalaCards
    ectomesenchymoma    malignant fibrous histiocytoma of bone    malignant mesenchymoma    gallbladder sarcoma
    mesenchymoma    undifferentiated embryonal sarcoma of the liver    botryoid rhabdomyosarcoma    pleomorphic rhabdomyosarcoma
    fibrous histiocytoma    embryonal sarcoma    histiocytoma    desmoplastic small round cell tumor
    alveolar soft part sarcoma    oculopharyngeal muscular dystrophy    mesenchymal chondrosarcoma    embryonal rhabdomyosarcoma
    skeletal muscle regeneration    myositis    rhabdoid tumor    leiomyosarcoma

    8 diseases from the University of Copenhagen DISEASES database for MYOD1:
    Rhabdomyosarcoma     Myopathy     Neuropathy     Alveolar soft part sarcoma
    Sarcoma     Ectomesenchymoma     Malignant mesenchymoma     Retinoblastoma

    MYOD1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MYOD1 gene (see all 35)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rhabdomyosarcoma 80.1 49 19299559 (5), 2260621 (5), 8383879 (5), 12783965 (2) (see all 25)
    rhabdomyosarcoma embryonal 69.3 5 16010486 (1), 18656317 (1), 19299559 (1), 16220232 (1)
    rhabdomyosarcoma alveolar 55.3 1 9256013 (1)
    sarcoma alveolar soft part 49 6 10383802 (4), 12778001 (1), 1656801 (1)
    rhabdoid tumor 44.4 1 2260621 (1)
    sarcoma extraosseous ewings 43.9 1 2260621 (1)
    hypertrophy 43.7 5 12716875 (1), 17661068 (1), 17395765 (1), 20124796 (1) (see all 5)
    retinoblastoma 41.9 5 7970718 (2), 12665587 (1), 10601020 (1), 8400456 (1)
    muscular dystrophies 41.6 2 19358679 (1), 18334989 (1)
    malignant fibrous histiocytoma 40 1 2260621 (1)

    Genetic Association Database (GAD): MYOD1
    Human Genome Epidemiology (HuGE) Navigator: MYOD1 (3 documents)
    Tumor Gene Database (TGDB): MYOD1

    Export disorders for MYOD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYOD1 gene, integrated from 10 sources (see all 632):
    (articles sorted by number of sources associating them with MYOD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Control of muscle development by dueling HATs and HDACs. (PubMed id 11532390)1, 2, 9 McKinsey T.A.... Olson E.N. (Curr. Opin. Genet. Dev. 2001)
    2. Genomewide linkage and peakwide association analyses of carotid plaque in Caribbean Hispanics. (PubMed id 20966410)1, 4 Dong C....Sacco R.L. ( a journal of cerebral circulation 2010)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    4. Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation. (PubMed id 16858404)1, 2 Mal A.K. (EMBO J. 2006)
    5. A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein. (PubMed id 9774340)1, 2 Breitschopf K.... Ciechanover A. (EMBO J. 1998)
    6. Methylation alterations of the MyoD1 upstream region are predictive of subclassification of human rhabdomyosarcomas. (PubMed id 9546368)1, 2 Chen B.... Parham D.M. (Am. J. Pathol. 1998)
    7. Human MyoD: cDNA and deduced amino acid sequence. (PubMed id 1850513)1, 2 Pearson-White S.H. (Nucleic Acids Res. 1991)
    8. Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products. (PubMed id 2583111)1, 2 Braun T....Arnold H.H. (EMBO J. 1989)
    9. Phosphorylation of nuclear MyoD is required for its rapid degradation. (PubMed id 9710583)1, 9 Song A....Harrington M.A. (Mol. Cell. Biol. 1998)
    10. Critical role for lysine 133 in the nuclear ubiquitin-mediated degradation of MyoD. (PubMed id 14660660)1, 9 Batonnet S....Leibovitch S.A. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4654 HGNC: 7611 AceView: MYOD1 Ensembl:ENSG00000129152 euGenes: HUgn4654
    ECgene: MYOD1 H-InvDB: MYOD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYOD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYOD1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/MyoD

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYOD1 gene:
    Search GeneIP for patents involving MYOD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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