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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYOCD Gene

protein-coding   GIFtS: 56
GCID: GC17P012569

myocardin
 Explore 22 diseases affiliated with
MYOCD via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MYOCD    

Aliases
for MYOCD gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Myocardin1
MYCD1 2 3

External Ids:    HGNC: 160671   Entrez Gene: 936492   Ensembl: ENSG000001410527   OMIM: 6061275   UniProtKB: Q8IZQ83   
ORGUL members:         

Export aliases for MYOCD gene to outside databases

Previous GC identifers: GC17P012771 GC17P012510


Summaries
for MYOCD gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MYOCD:
This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues.
It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and
smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the
smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for
this gene.(provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: MYCD_HUMAN, Q8IZQ8
Function: Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical
single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to
modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage
(myogenesis) (By similarity)

Gene Wiki entry for MYOCD


Genomic Views
for MYOCD gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYOCD gene promoter:
         AP-1   ATF-2   MyoD   c-Jun   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYOCD promoter sequence
   Search SABiosciences Chromatin IP Primers for MYOCD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYOCD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p12   HGNC cytogenetic band: 17p11.2

MYOCD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYOCD gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P012569:  view genomic region     (about GC identifiers)

Start:
 12,569,207 bp from pter      End:
 12,672,266 bp from pter
Size:
 103,060 bases      Orientation:
 plus strand

Proteins
for MYOCD gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MYCD_HUMAN, Q8IZQ8 (See protein sequence)
Recommended Name: Myocardin  
Size: 938 amino acids; 101997 Da
Subunit: Homodimer. Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex
formation (By similarity). Interacts with MLLT7/FOXO4. Interacts (via C-terminal) with EP300 (via the CREB-binding
domain). Interacts with HDAC4 and HDAC5 (By similarity). Interacts with MEF2C (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q5UBU5 Q8N7Q1
Alternative splicing: 3 isoforms:  Q8IZQ8-1   Q8IZQ8-2   Q8IZQ8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYOCD: NX_Q8IZQ8

Post-translational modifications:

  • Phosphorylation regulates negatively the intrinsic myocardin transcriptional activity (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IZQ8

    • MYOCD Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001139784.1  NP_001139785.1  NP_705832.1  

    ENSEMBL proteins: 
     ENSP00000462694   ENSP00000401678   ENSP00000341835   ENSP00000379311   ENSP00000400148  

    Human Recombinant Protein Products: 
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    Novus Biologicals MYOCD Lysate
    Browse Sino Biological Recombinant Proteins
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    Uscn Proteins for MYOCD

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA14970199


    MYOCD for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for MYOCD gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MYOCD for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR003034 SAP_dom
     IPR004018 RPEL_repeat

    Graphical View of Domain Structure for InterPro Entry Q8IZQ8

    ProtoNet protein and cluster: Q8IZQ8

    1 Blocks protein family: IPB003034 DNA-binding SAP

    UniProtKB/Swiss-Prot: MYCD_HUMAN, Q8IZQ8
    Domain: The C-terminal region contains a general transcription activation domain. The N-terminal region, comprising a
    basic and a Gln-rich domain, confers transcriptional potency and specificity by mediating association with the MADS
    box of SRF. The basic domain may be required for nuclear localization. The SAP domain is important for transactivation
    and ternary complex formation (By similarity)
    Similarity: Contains 3 RPEL repeats
    Similarity: Contains 1 SAP domain


    Function
    for MYOCD gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MYCD_HUMAN, Q8IZQ8
    Function: Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical
    single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to
    modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage
    (myogenesis) (By similarity)
    Induction: Up-regulated during heart failure

    miRNA
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    hsa-miR-124* hsa-miR-4317 hsa-miR-513a-5p hsa-miR-485-3p hsa-miR-128 hsa-miR-139-5p hsa-miR-519a hsa-miR-9
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    OriGene shRNA RFP: MYOCD
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001046core promoter sequence-specific DNA binding IDA19797053
    GO:0001076RNA polymerase II transcription factor binding transcription factor activity ISS--
    GO:0003676nucleic acid binding ----
    GO:0003713transcription coactivator activity IEA--
    GO:0005515protein binding IPI14970199


    MYOCD for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MYOCD:
     Decreased influenza A virus in 

    Animal Models:
         Mouse knock-outs for MYOCD: Myocdtm1.1Msp Myocdtm1Eno
         7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Myocd):
     cardiovascular system  embryogenesis  growth/size  homeostasis/metabolism  mortality/aging 
     muscle  normal 

    MYOCD for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MYOCD gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SRF and miRs in Smooth Muscle Differentiation and Proliferation
    		SRF and miRs in Smooth Muscle Differentiation and Proliferation1.00


    1 BioSystems Pathway for MYOCD 
        SRF and miRs in Smooth Muscle Differentiation and Proliferation


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYOCD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/24 Interacting proteins for MYOCD (Q8IZQ81, 3 ENSP000003418354) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRFP118311, 3, ENSP000002653544EBI-493384,EBI-493034 I2D: score=4 STRING: ENSP00000265354
    MKL1Q969V63, ENSP000003478474I2D: score=2 STRING: ENSP00000347847
    GSK3BP498413, ENSP000003248064I2D: score=1 STRING: ENSP00000324806
    HIF1ANQ9NWT63, ENSP000002991634I2D: score=1 STRING: ENSP00000299163
    KDM3AQ9Y4C13, ENSP000003236594I2D: score=1 STRING: ENSP00000323659
    About this table

    Gene Ontology (GO): 5/43 biological process terms (GO ID links to tree view) (see all 43):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001560regulation of cell growth by extracellular stimulus IEA--
    GO:0001570vasculogenesis IEA--
    GO:0001666response to hypoxia IEP19098903
    GO:0003231cardiac ventricle development IEA--


    MYOCD for ontologies           About GeneDecksing



    Drugs & Compounds
    for MYOCD gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MYOCD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MYOCD
    3 Novoseek chemical compound relationships for MYOCD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0.329 4 16614312 (1), 20388650 (1), 15256479 (1), 15913645 (1)
    nitric oxide 0 1 17913848 (1)
    retinoic acid 0 1 15231515 (1)

    Search CenterWatch for drugs/clinical trials and news about MYOCD / MYCD 

    Transcripts
    for MYOCD gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MYOCD gene (3 alternative transcripts): 
    NM_001146312.1  NM_001146313.1  NM_153604.2  

    Unigene Cluster for MYOCD:

    Myocardin
    Hs.567641  [show with all ESTs]
    Unigene Representative Sequence: NM_001146312
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000579237 ENST00000425538(uc002gno.2 uc002gnn.2 uc002gnq.2)
    ENST00000343344 ENST00000395988(uc002gnp.1) ENST00000443061

    miRNA
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    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate MYOCD (see all 44):
    hsa-miR-124* hsa-miR-4317 hsa-miR-513a-5p hsa-miR-485-3p hsa-miR-128 hsa-miR-139-5p hsa-miR-519a hsa-miR-9
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYOCD (see all 7)
    OriGene shRNA RFP: MYOCD
    OriGene siRNA: MYOCD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYOCD
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF532596.1 AK092562.1 AK095846.1 AK096753.1 AK097821.1 AK128608.1 AK292885.1 AY764180.1 
    BC126307.1 BC143391.1 BX640673.1 

    7 DOTS entries:

    DT.91869093  DT.101978090  DT.120963981  DT.442336  DT.100022414  DT.40269678  DT.101968799 

    24/61 AceView cDNA sequences (see all 61):

    AK096753 BX640673 AF532596 BM698841 AK097821 NM_153604 AW469178 BF438804 
    AA151562 AI972424 AI784583 BX098123 W76635 AA970354 AA708873 AK095846 
    AI452798 BQ000229 AI313447 AW181975 BQ719373 BQ882395 AI761915 AI684965 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MYOCD    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                                          -               
    SP2:                                                                                          
    SP3:                    -                                                                     
    SP4:                                                                                          


    ECgene alternative splicing isoforms for MYOCD

    Expression
    for MYOCD gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYOCD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGATGAAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MYOCD expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EndotheliumVeinsVascular Smooth Muscle CellsSmooth Muscle
    Head MesenchymePrechordal MesenchymeSmooth Muscle CellsNeural Crest, Smooth Muscle
    HeartAortic Arch ArteriesVascular Smooth Muscle CellsMyocardium, Neural Crest, Smooth Muscle
    HeartEndocardiumVascular Smooth Muscle CellsSmooth Muscle
    OvaryPrimordial FolliclePre-Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Smooth muscle-like cells (Generation of endoth...)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Cardiomyocyte-like progenitor cells (Derivation of cardio...)
    DKK1-induced cells (Derivation of cardio...)

    See MYOCD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYOCD

    SOURCE GeneReport for Unigene cluster: Hs.567641

    UniProtKB/Swiss-Prot: MYCD_HUMAN, Q8IZQ8
    Tissue specificity: Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder, small
    intestine, colon, lung, placenta and uterus. Very faint expression in prostate and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including MYOCD: 
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              Angiogenic Growth Factors in human mouse rat

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    In Situ
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    Orthologs
    for MYOCD gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MYOCD gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MYOCD1 myocardin 68.04(n)
    67(a)    		   427790  NM_001080715.1  NP_001074184.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MYOCD6
    		 --
    		 63(a)
    		 1 ↔ 1
    		 2(108721948-108749692)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003317251 myocardin-like 55.73(n)
    51.88(a)    		   100331725  XM_002663856.2  XP_002663902.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Mrtf6
    		 Myocardin-related transcription factor
    		 11(a)
    		 1 → many
    		 3L(2717615-2766480)


    ENSEMBL Gene Tree for MYOCD (if available)
    TreeFam Gene Tree for MYOCD (if available) 

    Paralogs
    for MYOCD gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYOCD gene
    MKL12  MKL22  
    3 SIMAP similar genes for MYOCD using alignment to 2 protein entries:     MYCD_HUMAN (see all proteins):
    DKFZp686O15128    MKL1    MKL2

    MYOCD for paralogs           About GeneDecksing



    Genomic Variants
    for MYOCD gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1924 NCBI SNPs in MYOCD are shown (see all 1924)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1392845121,2
    		Cother12537995(+) AGATGC/TGGGGA 6 A V mis11Minor allele frequency- T:0.00NA 4550
    rs802112701,2
    		--12463124(+) CTACAT/CTCGTG 2 -- us2k13Minor allele frequency- C:0.09CSA WA EA 240
    rs753852891,2
    		--12463135(+) GTAATC/TTGTTA 2 -- us2k10--------
    rs783402881,2
    		--12463358(+) GGGCTA/GACCCC 2 -- us2k13Minor allele frequency- G:0.08CSA WA 121
    rs1123390991,2
    		--12463560(+) AGCCCT/AAATTA 2 -- us2k12Minor allele frequency- A:0.06CSA WA 120
    rs728112601,2
    		C,--12463830(+) AGCCCA/GGTAGG 2 -- us2k13Minor allele frequency- G:0.07NA WA 240
    rs12338511,2
    		F,O,H,--12463869(+) CCATTC/GCCTCG 2 -- us2k16Minor allele frequency- G:0.01MN NS EA NA 722
    rs769880581,2
    		F,--12464028(+) ACAGAA/GTCGTC 2 -- us2k11Minor allele frequency- G:0.15WA 118
    rs80710721,2
    		C,F,A,--12464270(+) CCAGGA/TCCTCG 2 -- us2k15Minor allele frequency- T:0.42NA WA EA 362
    rs7581871,2
    		C,F,A,H,--12464464(+) GCCGGT/CTCCCG 2 -- us2k112Minor allele frequency- C:0.26MN NS NA WA CSA EA 675

    HapMap Linkage Disequilibrium report for MYOCD (12569207 - 12672266 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for MYOCD
         2 CNVs: 47896 39193
    Human Gene Mutation Database (HGMD): MYOCD

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    Disorders / Diseases
    for MYOCD gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MYOCD for disorders           About GeneDecksing

    OMIM gene information: 606127    OMIM disorders: --

    20/22 diseases for MYOCD (see all 22):    About MalaCards
    double outlet right ventricle    retroperitoneal leiomyosarcoma    hypertrophic cardiomyopathy    megakaryoblastic leukemia
    leiomyosarcoma    dilated cardiomyopathy    cardiomyopathy    fainting
    alzheimer's disease    vascular disease    myocarditis    atherosclerosis
    ovarian cancer    nasopharyngitis    leukemia    hypertension
    cerebritis    cervicitis    hypoxia    hepatitis

    6 Novoseek disease relationships for MYOCD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypertrophy 32.5 7 16556869 (4), 18204489 (1)
    atherosclerosis 28.9 1 19237536 (1)
    alzheimers disease 15.8 1 19237536 (1)
    leukemia 0 2 14970199 (1), 16556869 (1)
    cardiomyopathy 0 1 12920479 (1)
    tumors 0 7 17495540 (2), 19952936 (2), 19276386 (1), 17292825 (1)

    Human Genome Epidemiology (HuGE) Navigator: MYOCD (6 documents)

    Export disorders for MYOCD gene to outside databases

    Publications
    for MYOCD gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYOCD gene, integrated from 9 sources (see all 136):
    (articles sorted by number of sources associating them with MYOCD)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Potentiation of serum response factor activity by a family of myocardin-related transcription factors. (PubMed id 12397177)1, 2, 3, 9 Wang D.-Z.... Olson E.N. (2002)
    2. Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. (PubMed id 12640126)1, 2, 9 Du K.L.... Parmacek M.S. (2003)
    3. Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. (PubMed id 16054032)1, 2, 9 Liu Z.-P.... Olson E.N. (2005)
    4. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. (PubMed id 11439182)1, 3, 9 Wang D....Olson E.N. (2001)
    5. Activation of cardiac and smooth muscle-specific genes in primary human cells after forced expression of human myocardin. (PubMed id 15907818)1, 2, 9 van Tuyn J....Atsma D.E. (2005)
    6. Expression and functional activity of four myocardin isoforms. (PubMed id 20385216)1, 2 Imamura M....Miano J.M. (2010)
    7. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Myocardin functions as an effective inducer of growth arrest and differentiation in human uterine leiomyosarcoma cells. (PubMed id 20068148)1, 9 Kimura Y....Sobue K. (2010)
    10. Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect. (PubMed id 17292825)1, 9 Milyavsky M....Rotter V. (2007)

    External Searches for MYOCD gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MYOCD gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93649 HGNC: 16067 AceView: MYOCD Ensembl:ENSG00000141052 euGenes: HUgn93649
    ECgene: MYOCD H-InvDB: MYOCD

    Other Databases showing MYOCD gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MYOCD gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYOCD Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MYOCD gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MYOCD gene:
    Search GeneIP for patents involving MYOCD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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