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Aliases for MYOCD Gene

Aliases for MYOCD Gene

  • Myocardin 2 3 5
  • MYCD 3 4

External Ids for MYOCD Gene

Previous GeneCards Identifiers for MYOCD Gene

  • GC17P012771
  • GC17P012510

Summaries for MYOCD Gene

Entrez Gene Summary for MYOCD Gene

  • This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

GeneCards Summary for MYOCD Gene

MYOCD (Myocardin) is a Protein Coding gene. Diseases associated with MYOCD include conotruncal heart malformations. Among its related pathways are HOP Signaling and SRF and miRs in Smooth Muscle Differentiation and Proliferation. GO annotations related to this gene include nucleic acid binding and transcription coactivator activity. An important paralog of this gene is MKL1.

UniProtKB/Swiss-Prot for MYOCD Gene

  • Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity).

Gene Wiki entry for MYOCD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYOCD Gene

Genomics for MYOCD Gene

Regulatory Elements for MYOCD Gene

Promoters for MYOCD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYOCD on UCSC Golden Path with GeneCards custom track

Genomic Location for MYOCD Gene

Chromosome:
17
Start:
12,665,890 bp from pter
End:
12,768,949 bp from pter
Size:
103,060 bases
Orientation:
Plus strand

Genomic View for MYOCD Gene

Genes around MYOCD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYOCD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYOCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYOCD Gene

Proteins for MYOCD Gene

  • Protein details for MYOCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZQ8-MYCD_HUMAN
    Recommended name:
    Myocardin
    Protein Accession:
    Q8IZQ8
    Secondary Accessions:
    • Q5UBU5
    • Q8N7Q1

    Protein attributes for MYOCD Gene

    Size:
    938 amino acids
    Molecular mass:
    101997 Da
    Quaternary structure:
    • Homodimer. Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex formation (By similarity). Interacts with MLLT7/FOXO4. Interacts (via C-terminal) with EP300 (via the CREB-binding domain). Interacts with HDAC4 and HDAC5 (By similarity). Interacts with MEF2C (By similarity).

    Alternative splice isoforms for MYOCD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYOCD Gene

Proteomics data for MYOCD Gene at MOPED

Post-translational modifications for MYOCD Gene

  • Phosphorylation regulates negatively the intrinsic myocardin transcriptional activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYOCD Gene

No data available for DME Specific Peptides for MYOCD Gene

Domains & Families for MYOCD Gene

Protein Domains for MYOCD Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MYOCD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZQ8

UniProtKB/Swiss-Prot:

MYCD_HUMAN :
  • The C-terminal region contains a general transcription activation domain. The N-terminal region, comprising a basic and a Gln-rich domain, confers transcriptional potency and specificity by mediating association with the MADS box of SRF. The basic domain may be required for nuclear localization. The SAP domain is important for transactivation and ternary complex formation (By similarity).
  • Contains 3 RPEL repeats.
Domain:
  • The C-terminal region contains a general transcription activation domain. The N-terminal region, comprising a basic and a Gln-rich domain, confers transcriptional potency and specificity by mediating association with the MADS box of SRF. The basic domain may be required for nuclear localization. The SAP domain is important for transactivation and ternary complex formation (By similarity).
  • Contains 1 SAP domain.
Similarity:
  • Contains 3 RPEL repeats.
genes like me logo Genes that share domains with MYOCD: view

No data available for Gene Families for MYOCD Gene

Function for MYOCD Gene

Molecular function for MYOCD Gene

UniProtKB/Swiss-Prot Function:
Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated during heart failure.

Gene Ontology (GO) - Molecular Function for MYOCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding IDA 19797053
GO:0035035 histone acetyltransferase binding IEA --
genes like me logo Genes that share ontologies with MYOCD: view
genes like me logo Genes that share phenotypes with MYOCD: view

Animal Models for MYOCD Gene

MGI Knock Outs for MYOCD:

Animal Model Products

miRNA for MYOCD Gene

miRTarBase miRNAs that target MYOCD

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYOCD Gene

Localization for MYOCD Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYOCD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYOCD Gene COMPARTMENTS Subcellular localization image for MYOCD gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
mitochondrion 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for MYOCD Gene

Pathways & Interactions for MYOCD Gene

genes like me logo Genes that share pathways with MYOCD: view

Pathways by source for MYOCD Gene

1 Qiagen pathway for MYOCD Gene

SIGNOR curated interactions for MYOCD Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MYOCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0001666 response to hypoxia IEP 19098903
GO:0003231 cardiac ventricle development IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA,IDA --
GO:0007507 heart development IEA --
genes like me logo Genes that share ontologies with MYOCD: view

Drugs & Compounds for MYOCD Gene

(2) Drugs for MYOCD Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for MYOCD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MYOCD: view

Transcripts for MYOCD Gene

Unigene Clusters for MYOCD Gene

Myocardin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYOCD Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for MYOCD Gene

GeneLoc Exon Structure for
MYOCD
ECgene alternative splicing isoforms for
MYOCD

Expression for MYOCD Gene

mRNA expression in normal human tissues for MYOCD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYOCD Gene

This gene is overexpressed in Artery - Aorta (x5.4), Colon - Sigmoid (x5.1), Artery - Tibial (x4.7), Artery - Coronary (x4.6), and Esophagus - Muscularis (x4.4).

Protein differential expression in normal tissues from HIPED for MYOCD Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYOCD Gene



SOURCE GeneReport for Unigene cluster for MYOCD Gene Hs.567641

mRNA Expression by UniProt/SwissProt for MYOCD Gene

Q8IZQ8-MYCD_HUMAN
Tissue specificity: Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder, small intestine, colon, lung, placenta and uterus. Very faint expression in prostate and skeletal muscle.
genes like me logo Genes that share expression patterns with MYOCD: view

Protein tissue co-expression partners for MYOCD Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for MYOCD Gene

This gene was present in the common ancestor of animals.

Orthologs for MYOCD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC539517 35
  • 84.34 (n)
  • 83.96 (a)
-- 36
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MYOCD 35
  • 85.45 (n)
  • 85.99 (a)
-- 36
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Myocd 35
  • 82.59 (n)
  • 83.18 (a)
Myocd 16
Myocd 36
  • 83 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia MYOCD 35
  • 99.46 (n)
  • 99.39 (a)
MYOCD 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Myocd 35
  • 82.13 (n)
  • 83.03 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves MYOCD 35
  • 71.79 (n)
  • 70.85 (a)
MYOCD 36
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia myocd 35
  • 64.73 (n)
  • 60.82 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100331725 35
  • 54.84 (n)
  • 50.26 (a)
MYOCD 36
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mrtf 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5092 36
  • 37 (a)
OneToMany
Species with no ortholog for MYOCD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYOCD Gene

ENSEMBL:
Gene Tree for MYOCD (if available)
TreeFam:
Gene Tree for MYOCD (if available)

Paralogs for MYOCD Gene

Paralogs for MYOCD Gene

(3) SIMAP similar genes for MYOCD Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MYOCD: view

Variants for MYOCD Gene

Sequence variations from dbSNP and Humsavar for MYOCD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs16713 -- 12,715,310(+) TCCCC(-/CCT/CT)GTTTG intron-variant
rs1465249 -- 12,735,977(+) CTCCA(C/T)GCCAA intron-variant
rs1519251 -- 12,671,184(-) TACCC(C/T)ATAAA intron-variant
rs1106625 -- 12,718,709(-) CTGCC(C/T)CACGC intron-variant
rs1106626 -- 12,718,689(-) CCTCC(C/T)ATCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYOCD Gene

Variant ID Type Subtype PubMed ID
esv34095 CNV Loss 18971310
esv2715663 CNV Deletion 23290073
nsv524458 CNV Loss 19592680

Variation tolerance for MYOCD Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.76; 66.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYOCD Gene

HapMap Linkage Disequilibrium report
MYOCD
Human Gene Mutation Database (HGMD)
MYOCD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYOCD Gene

Disorders for MYOCD Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYOCD Gene - From: DISEASES

Disorder Aliases PubMed IDs
conotruncal heart malformations
  • double-outlet right ventricle
- elite association - COSMIC cancer census association via MalaCards
Search MYOCD in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYOCD

Genetic Association Database (GAD)
MYOCD
Human Genome Epidemiology (HuGE) Navigator
MYOCD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYOCD
genes like me logo Genes that share disorders with MYOCD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYOCD Gene

Publications for MYOCD Gene

  1. Potentiation of serum response factor activity by a family of myocardin-related transcription factors. (PMID: 12397177) Wang D.-Z. … Olson E.N. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 23 67
  2. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. (PMID: 11439182) Wang D. … Olson E.N. (Cell 2001) 2 3 23
  3. Use of myocardin in the classification of mesenchymal tumors of the uterus. (PMID: 19952936) Liang J. … Zheng H. (Int. J. Gynecol. Pathol. 2010) 3 23
  4. Myocardin functions as an effective inducer of growth arrest and differentiation in human uterine leiomyosarcoma cells. (PMID: 20068148) Kimura Y. … Sobue K. (Cancer Res. 2010) 3 23
  5. SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. (PMID: 19098903) Bell R.D. … Zlokovic B.V. (Nat. Cell Biol. 2009) 3 23

Products for MYOCD Gene

Sources for MYOCD Gene

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