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Aliases for MYOCD Gene

Aliases for MYOCD Gene

  • Myocardin 2 3
  • MYCD 3 4

External Ids for MYOCD Gene

Summaries for MYOCD Gene

Entrez Gene Summary for MYOCD Gene

  • This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

GeneCards Summary for MYOCD Gene

MYOCD (Myocardin) is a Protein Coding gene. Diseases associated with MYOCD include retroperitoneal leiomyosarcoma. Among its related pathways are HOP Signaling and SRF and miRs in Smooth Muscle Differentiation and Proliferation. GO annotations related to this gene include transcription factor binding and protein domain specific binding. An important paralog of this gene is MKL2.

UniProtKB/Swiss-Prot for MYOCD Gene

  • Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity).

Gene Wiki entry for MYOCD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYOCD Gene

Genomics for MYOCD Gene

Genomic Location for MYOCD Gene

Start:
12,665,890 bp from pter
End:
12,768,949 bp from pter
Size:
103,060 bases
Orientation:
Plus strand

Genomic View for MYOCD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYOCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYOCD Gene

Regulatory Elements for MYOCD Gene

Proteins for MYOCD Gene

  • Protein details for MYOCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZQ8-MYCD_HUMAN
    Recommended name:
    Myocardin
    Protein Accession:
    Q8IZQ8
    Secondary Accessions:
    • Q5UBU5
    • Q8N7Q1

    Protein attributes for MYOCD Gene

    Size:
    938 amino acids
    Molecular mass:
    101997 Da
    Quaternary structure:
    • Homodimer. Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex formation (By similarity). Interacts with MLLT7/FOXO4. Interacts (via C-terminal) with EP300 (via the CREB-binding domain). Interacts with HDAC4 and HDAC5 (By similarity). Interacts with MEF2C (By similarity).

    Alternative splice isoforms for MYOCD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYOCD Gene

Proteomics data for MYOCD Gene at MOPED

Post-translational modifications for MYOCD Gene

  • Phosphorylation regulates negatively the intrinsic myocardin transcriptional activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYOCD Gene

No data available for DME Specific Peptides for MYOCD Gene

Domains for MYOCD Gene

Protein Domains for MYOCD Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

MYCD_HUMAN
Domain:
  • The C-terminal region contains a general transcription activation domain. The N-terminal region, comprising a basic and a Gln-rich domain, confers transcriptional potency and specificity by mediating association with the MADS box of SRF. The basic domain may be required for nuclear localization. The SAP domain is important for transactivation and ternary complex formation (By similarity).:
    • Q8IZQ8
  • Contains 1 SAP domain.:
    • Q8IZQ8
Similarity:
  • Contains 3 RPEL repeats.:
    • Q8IZQ8
genes like me logo Genes that share domains with MYOCD: view

No data available for Gene Families for MYOCD Gene

Function for MYOCD Gene

Molecular function for MYOCD Gene

UniProtKB/Swiss-Prot Function: Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity).
UniProtKB/Swiss-Prot Induction: Up-regulated during heart failure.

Gene Ontology (GO) - Molecular Function for MYOCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding IDA 19797053
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity ISS --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 22157009
GO:0003676 nucleic acid binding --
GO:0003713 transcription coactivator activity IEA --
genes like me logo Genes that share ontologies with MYOCD: view
genes like me logo Genes that share phenotypes with MYOCD: view

Animal Models for MYOCD Gene

MGI Knock Outs for MYOCD:

miRNA for MYOCD Gene

miRTarBase miRNAs that target MYOCD

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MYOCD Gene

Localization for MYOCD Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYOCD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYOCD Gene COMPARTMENTS Subcellular localization image for MYOCD gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MYOCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14970199
genes like me logo Genes that share ontologies with MYOCD: view

Pathways for MYOCD Gene

genes like me logo Genes that share pathways with MYOCD: view

Pathways by source for MYOCD Gene

1 Qiagen pathway for MYOCD Gene

Gene Ontology (GO) - Biological Process for MYOCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001560 regulation of cell growth by extracellular stimulus IEA --
GO:0001570 vasculogenesis IEA --
GO:0001666 response to hypoxia IEP 19098903
GO:0003231 cardiac ventricle development IEA --
genes like me logo Genes that share ontologies with MYOCD: view

Compounds for MYOCD Gene

(3) Novoseek inferred chemical compound relationships for MYOCD Gene

Compound -log(P) Hits PubMed IDs
calcium 0.329 4
nitric oxide 0 1
retinoic acid 0 1
genes like me logo Genes that share compounds with MYOCD: view

Transcripts for MYOCD Gene

Unigene Clusters for MYOCD Gene

Myocardin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYOCD Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for MYOCD Gene

GeneLoc Exon Structure for
MYOCD
ECgene alternative splicing isoforms for
MYOCD

Expression for MYOCD Gene

mRNA expression in normal human tissues for MYOCD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYOCD Gene

This gene is overexpressed in Artery - Aorta (5.4), Colon - Sigmoid (5.1), Artery - Tibial (4.7), Artery - Coronary (4.6), and Esophagus - Muscularis (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYOCD Gene

SOURCE GeneReport for Unigene cluster for MYOCD Gene Hs.567641

mRNA Expression by UniProt/SwissProt for MYOCD Gene

Q8IZQ8-MYCD_HUMAN
Tissue specificity: Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder, small intestine, colon, lung, placenta and uterus. Very faint expression in prostate and skeletal muscle.
genes like me logo Genes that share expressions with MYOCD: view

Orthologs for MYOCD Gene

This gene was present in the common ancestor of animals.

Orthologs for MYOCD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYOCD 36
  • 99.46 (n)
  • 99.39 (a)
MYOCD 37
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 37
  • 83 (a)
OneToMany
LOC539517 36
  • 84.34 (n)
  • 83.96 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 85 (a)
OneToMany
MYOCD 36
  • 85.45 (n)
  • 85.99 (a)
mouse
(Mus musculus)
Mammalia Myocd 36
  • 82.59 (n)
  • 83.18 (a)
Myocd 16
Myocd 37
  • 83 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 59 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Myocd 36
  • 82.13 (n)
  • 83.03 (a)
chicken
(Gallus gallus)
Aves MYOCD 36
  • 71.79 (n)
  • 70.85 (a)
MYOCD 37
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia myocd 36
  • 64.73 (n)
  • 60.82 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100331725 36
  • 54.84 (n)
  • 50.26 (a)
MYOCD 37
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mrtf 37
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5092 37
  • 37 (a)
OneToMany
Species with no ortholog for MYOCD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYOCD Gene

ENSEMBL:
Gene Tree for MYOCD (if available)
TreeFam:
Gene Tree for MYOCD (if available)

Paralogs for MYOCD Gene

Paralogs for MYOCD Gene

Selected SIMAP similar genes for MYOCD Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MYOCD: view

Variants for MYOCD Gene

Sequence variations from dbSNP and Humsavar for MYOCD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs16713 -- 12,715,310(+) TCCCC(-/CT)GTTTG intron-variant
rs740463 -- 12,731,771(-) GCCCA(C/G)AAGGC intron-variant
rs757597 -- 12,738,015(+) ACGGT(A/G)TATCA intron-variant
rs758185 -- 12,731,898(+) TGTGT(C/G)TGGGC intron-variant
rs758187 -- 12,665,754(+) GCCGG(C/T)TCCCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MYOCD Gene

Variant ID Type Subtype PubMed ID
esv34095 CNV Loss 18971310
esv2715663 CNV Deletion 23290073
nsv524458 CNV Loss 19592680

Relevant External Links for MYOCD Gene

HapMap Linkage Disequilibrium report
MYOCD
Human Gene Mutation Database (HGMD)
MYOCD

Disorders for MYOCD Gene

(6) Novoseek inferred disease relationships for MYOCD Gene

Disease -log(P) Hits PubMed IDs
hypertrophy 32.5 5
atherosclerosis 28.9 1
alzheimers disease 15.8 1
leukemia 0 2
cardiomyopathy 0 1

Relevant External Links for MYOCD

Genetic Association Database (GAD)
MYOCD
Human Genome Epidemiology (HuGE) Navigator
MYOCD
genes like me logo Genes that share disorders with MYOCD: view

No data available for UniProtKB/Swiss-Prot for MYOCD Gene

Publications for MYOCD Gene

  1. Potentiation of serum response factor activity by a family of myocardin-related transcription factors. (PMID: 12397177) Wang D.-Z. … Olson E.N. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 23
  2. Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. (PMID: 12640126) Du K.L. … Parmacek M.S. (Mol. Cell. Biol. 2003) 3 4 23
  3. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. (PMID: 11439182) Wang D. … Olson E.N. (Cell 2001) 2 3 23
  4. Activation of cardiac and smooth muscle-specific genes in primary human cells after forced expression of human myocardin. (PMID: 15907818) van Tuyn J. … Atsma D.E. (Cardiovasc. Res. 2005) 3 4 23
  5. Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. (PMID: 16054032) Liu Z.-P. … Olson E.N. (Dev. Cell 2005) 3 4 23

Products for MYOCD Gene

Sources for MYOCD Gene

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