MYOC Gene
protein-coding GIFtS: 56
GCID: GC01M171604
|
|
myocilin, trabecular meshwork inducible glucocorticoid response
(Previous symbol: GLC1A)
| |
Aliases
for MYOC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Myocilin, Trabecular Meshwork Inducible Glucocorticoid Response1 2 | | JOAG2 5 | | GLC1A1 2 3 5 | | Mutated Trabecular Meshwork-Induced Glucocorticoid Response Protein2 | | TIGR1 2 3 5 | | Myocilin1 | | JOAG11 2 | | Trabecular Meshwork-Induced Glucocorticoid Response Protein3 | | GPOA2 5 | | |
Export aliases for MYOC gene to outside databasesPrevious GC identifers: GC01M169168 GC01M167233 GC01M168185 GC01M168843 GC01M168336 GC01M169871 GC01M142827 |
Summaries
for MYOC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MYOC:
MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in manyoccular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshworkglucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential inregulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onsetopen-angle glaucoma. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MYOC_HUMAN, Q99972Function: May participate in the obstruction of fluid outflow in the trabecular meshwork
Gene Wiki entry for MYOC
|
Genomic Views
for MYOC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MYOC gene promoter:
AhR AML1a NRSF form 1 POU3F2 NRSF form 2 Max FOXC1 FOXO4 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for MYOC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYOC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q23-q24 Ensembl cytogenetic band: 1q24.3 HGNC cytogenetic band: 1q23-q24MYOC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M171604: view genomic region
(about GC identifiers)
Start:
|
171,604,557 bp from pter |
End:
|
171,621,811 bp from pter |
Size:
|
17,255 bases |
Orientation:
|
minus strand |
|
Proteins
for MYOC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MYOC_HUMAN, Q99972 (See
protein sequence)Recommended Name: Myocilin precursor Size: 504 amino acids; 56972 Da
Subunit: Homodimer. Interacts with OLFM3
Subcellular location: Rough endoplasmic reticulum. Secreted. Cell projection, cilium. Note=Located preferentially inthe ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmicreticulum. Also secreted
Sequence caution: Sequence=BAA24532.1; Type=Erroneous initiation;
Secondary accessions: B2RD84 O00620 Q7Z6Q9Explore the universe of human proteins at neXtProt for MYOC: NX_Q99972
Post-translational modifications:
Different isoforms may arise by post-translational modifications1
Glycosylated1
Palmitoylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99972
MYOC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000252.1
ENSEMBL proteins: ENSP00000037502
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MYOC for ontologies About GeneDecksing
MYOC Antibody Products:
Assay Products for MYOC: |
Protein
Domains /
Families
for MYOC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MYOC for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q99972ProtoNet protein and cluster: Q99972 1 Blocks protein family: IPB003112 Olfactomedin-like
UniProtKB/Swiss-Prot: MYOC_HUMAN, Q99972Similarity: Contains 1 olfactomedin-like domain |
Function
for MYOC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MYOC_HUMAN, Q99972Function: May participate in the obstruction of fluid outflow in the trabecular meshwork Genatlas biochemistry entry for MYOC:myocilin,cytoskeleton protein with multiple post-translational forms,cellular (55kDa) and secreted 55/66kDa,expressedin ciliated cells of cochlea and involved in the morphogenesis of ciliary body,a major organizing center of theciliated epithelium, also expressed in iris,sclera,neural retina,heart,skeletal muscle,olfactory neuroepithelium(homolog of frog neuronal olfactomedin related protein)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYOC (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYOC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MYOC (NM_000261) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYOC | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYOC |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOC |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
TAS | 9169133 |
MYOC for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MYOC:
Animal Models:
2 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Myoc):
MYOC for phenotypes About GeneDecksing
|
Pathways & Interactions
for MYOC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYOC
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/38 Interacting proteins for MYOC (Q999723 ENSP000000375024) via UniProtKB, MINT, STRING, and/or I2D (see all 38)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009653 | anatomical structure morphogenesis |
TAS | 9169133 |
MYOC for ontologies About GeneDecksing
|
Drugs & Compounds
for MYOC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MYOC for compounds About GeneDecksing
 Browse Tocris compounds for MYOC
10/16 Novoseek chemical compound relationships for MYOC gene (see all 16) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| dexamethasone |
57.1 |
53 |
19696178 (3), 18195223 (3), 19064852 (2), 10550794 (2) (see all 24) |
| leucine |
47 |
9 |
9176893 (1), 11773029 (1), 16289048 (1), 12219254 (1) (see all 8) |
| polyacrylamide |
13.3 |
1 |
11431441 (1) |
| steroid |
12.2 |
19 |
11133859 (6), 15456875 (3), 20447966 (1), 11431441 (1) |
| asparagine |
11.2 |
2 |
9556305 (1), 9754180 (1) |
| hyaluronic acid |
7.2 |
2 |
14578398 (1), 9497363 (1) |
| glycosaminoglycan |
0 |
1 |
9497363 (1) |
| nickel |
0 |
2 |
16384965 (1), 11095610 (1) |
| sucrose |
0 |
2 |
15944158 (1), 17094967 (1) |
| lipid |
0 |
3 |
17149370 (1), 16198165 (1) |
Search CenterWatch for drugs/clinical trials and news about MYOC
|
Transcripts
for MYOC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MYOC gene: NM_000261.1 Unigene Cluster for MYOC: Myocilin, trabecular meshwork inducible glucocorticoid response Hs.436037 [show with all ESTs]Unigene Representative Sequence: BC0292611 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000037502(uc001ghu.3 uc010pmk.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYOC (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYOC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MYOC (NM_000261) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYOC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYOC |
Additional cDNA sequence: AF001620.1 AK097310.1 AK300924.1 AK300943.1 AK301297.1 AK315443.1 BC029261.1 D88214.1 FJ227302.1 FJ237046.1 FJ237047.1 U85257.1 3 DOTS entries: DT.111574 DT.121415600 DT.95158302 24/95 AceView cDNA sequences (see all 95): BC029261 BM707284 CD677391 BF063281 BM689172 CD679237 CD678378 CD676838 BU727147 CD677407 CD676891 U85257 AI971049 BF726094 BP342027 CD679214 BI821411 AW772701 CD676728 CD678994 BF725009 CD677693 AW292263 NM_000261
GeneLoc Exon Structure
|
Expression
for MYOC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MYOC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MYOC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYOC
SOURCE GeneReport for Unigene cluster: Hs.436037
UniProtKB/Swiss-Prot: MYOC_HUMAN, Q99972Tissue specificity: Expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletalmuscle, heart and other tissues. Expressed predominantly in the retina. In normal eyes, found in the inner uvealmeshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in moreregions of the meshwork and appeared more intensively than in normal eyes, regardless of the type or clinical severityof glaucoma
SABiosciences Custom PCR Arrays for MYOC
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYOC
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYOC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYOC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYOC | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOC |
Orthologs
for MYOC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MYOC gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MYOC1 |
myocilin, trabecular meshwork inducible glucocorticoid more |
63.69(n)
61.29(a) |
|
424391 XM_422235.3 XP_422235.3 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.230152 |
Xenopus laevis transcribed sequence with weak similarity more |
75.83(n) |
|
BJ031036.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
myoc1 |
myocilin |
57.55(n)
51.65(a) |
|
548602 NM_001015062.2 NP_001015062.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG68676 |
-- |
8(a) |
1 → many |
X(17917903-17922294) |
worm
(Caenorhabditis elegans) |
Secernentea |
cof-26unc-1226 |
UNCoordinated family member (unc-122) |
17(a)14(a) |
many ↔ manymany ↔ many |
I(6250573-6252823) I(14872151-14875367) |
ENSEMBL Gene Tree for MYOC (if available)
TreeFam Gene Tree for MYOC (if available) |
Paralogs
for MYOC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MYOC gene
- GLDN2 OLFM32 OLFML2B2 OLFML32 OLFML2A2 OLFM22 OLFM12 OLFML12
- OLFM42
10 SIMAP similar genes for MYOC using alignment to 5 protein entries: MYOC_HUMAN (see all proteins):OLFM1 LPHN2 LPHN3 OLFM2 OLFML2B OLFM3
FLJ00237 LPHN1 DKFZp686H1812 OLFML1
MYOC for paralogs About GeneDecksing
|
Genomic Variants
for MYOC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MYOC (171604557 - 171621811 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MYOC
2 CNVs: 70414 70415
Human Gene Mutation Database (HGMD): MYOC
Locus Specific Mutation Databases (LSDB): MYOC
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYOC |
|
Disorders
/ Diseases
for MYOC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MYOC for disorders About GeneDecksing
OMIM gene information: 601652
OMIM disorders: 137750
UniProtKB/Swiss-Prot: MYOC_HUMAN, Q99972
Defects in MYOC are the cause of primary open angle glaucoma type 1A (GLC1A) [MIM:137750]. Primary open angleglaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of theanterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomaticuntil the late stages, by which time significant and irreversible optic nerve damage has already taken place Defects in MYOC are a cause of primary congenital glaucoma type 3A (GLC3A) [MIM:231300]. An autosomalrecessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressureat birth or early choldhood, large ocular globes (buphthalmos) and corneal edema. It results from developmentaldefects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueoushumor. Note=MYOC variations may contribute to GLC3A via digenic inheritance with CYP1B1 and/or another locusassociated with the disease
20/27  diseases for MYOC (see all 27): About MalaCardsopen-angle glaucoma glaucoma angle-closure glaucoma glaucoma, early-onset, digenic
primary angle-closure glaucoma primary open angle glaucoma leber hereditary optic neuropathy steroid-induced glaucoma
early-onset glaucoma peters anomaly corneal dystrophy ocular hypertension
primary congenital glaucoma microcoria glaucoma, congenital corneal edema
buphthalmos juvenile glaucoma eye disease myopia
2 diseases from the University of Copenhagen DISEASES database for MYOC:Glaucoma Blindness 10/24 Novoseek disease relationships for MYOC gene (see all 24) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| glc1a |
97.9 |
99 |
8684791 (9), 9548973 (6), 10209734 (5), 12851728 (5) (see all 32) |
| primary open angle glaucoma |
94.2 |
82 |
10878948 (3), 15547491 (2), 9446806 (2), 10340788 (2) (see all 47) |
| glaucoma open-angle |
94 |
162 |
8684791 (5), 12504739 (3), 19662433 (3), 9535666 (3) (see all 89) |
| glaucoma |
91.8 |
329 |
15456875 (7), 8684791 (5), 12697062 (5), 17197538 (5) (see all 99) |
| glaucoma, primary open angle, adult-onset |
86.3 |
1 |
15069026 (1) |
| aqueous humor |
82.5 |
61 |
16384965 (6), 11527946 (4), 15235575 (4), 11152659 (3) (see all 26) |
| ocular hypertension |
81.5 |
24 |
11133859 (3), 16973161 (2), 11431441 (2), 11815346 (2) (see all 12) |
| glaucoma, congenital |
81 |
15 |
18852424 (3), 19148291 (1), 20198978 (1), 17224759 (1) (see all 10) |
| corticosteroid-induced glaucoma |
79.2 |
1 |
15194423 (1) |
| glaucoma suspect |
69 |
4 |
12215093 (1), 10919117 (1) |
Genetic Association Database (GAD): MYOC
Human Genome Epidemiology (HuGE) Navigator: MYOC (58 documents)
Export disorders for MYOC gene to outside databases
|
Publications
for MYOC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MYOC gene, integrated from 9 sources (see all 350):
(articles sorted by number of sources associating them with MYOC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene. (PubMed id 11774072)1, 2, 4, 9 Vincent A.L.... Heon E. (2002)
- Myocilin gene implicated in primary congenital glaucoma. (PubMed id 15733270)1, 2, 4, 9 Kaur K.... Chakrabarti S. (2005)
- Prevalence of myocilin mutations in adults with primary open-angle glaucoma in Ghana, West Africa. (PubMed id 12362081)1, 2, 4, 9 Challa P.... Allingham R.R. (2002)
- Novel MYOC gene mutation, Phe369Leu, in Japanese patients with primary open-angle glaucoma detected by denaturing high-performance liquid chromatography. (PubMed id 15534471)1, 2, 4, 9 Ishikawa K....Mashima Y. (2004)
- A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: molecular cloning, tissue expression, and chromosomal mapping. (PubMed id 9169133)1, 2, 3, 9 Kubota R.... Shimizu N. (1997)
- Myocilin analysis by DHPLC in French POAG patients: increased prevalence of Q368X mutation. (PubMed id 12872267)1, 2, 4 Melki R.... Garchon H.-J. (2003)
- Identification of a gene that causes primary open angle glaucoma. (PubMed id 9005853)1, 2, 3 Stone E.M....Sheffield V.C. (1997)
- Characterization of rabbit myocilin: implications for human myocilin glycosylation and signal peptide usage. (PubMed id 12697062)1, 2, 9 Shepard A.R.... Clark A.F. (2003)
- [Study of TIGR gene in patients with primary open angle glaucoma] (PubMed id 15646469)1, 4, 9 Krawczynski M.R....Latos-Bielenska A. (2004)
- Evaluation of the myocilin (MYOC) glaucoma gene in monkey and human steroid-induced ocular hypertension. (PubMed id 11133859)1, 4, 9 Fingert J.H....Stone E.M. (2001)
|
External Searches for MYOC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MYOC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MYOC gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MYOC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MYOC | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MYOC |
|
| | |
About This Section
| Patent Information for MYOC gene:
Search GeneIP for patents involving MYOC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MYOC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MYOC | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYOC | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYOC | | | OriGene Protein Over-expression Lysate for MYOC | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MYOC | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYOC | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYOC | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MYOC | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MYOC | | OriGene Custom Protein Services for MYOC | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MYOC | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYOC | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYOC | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYOC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYOC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYOC |
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| | | | Search Tocris compounds for MYOC |
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 | | | MYOC Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYOC |
|  |  |  | | | | Search ThermoFisher Antibodies for MYOC |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYOC |
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