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Aliases for MYO9B Gene

Aliases for MYO9B Gene

  • Myosin IXB 2 3 5
  • Unconventional Myosin-9b 3 4
  • MYR5 3 4
  • Unconventional Myosin-IXb 3
  • Myosin-IXb 3
  • CELIAC4 3

External Ids for MYO9B Gene

Previous HGNC Symbols for MYO9B Gene

  • CELIAC4

Previous GeneCards Identifiers for MYO9B Gene

  • GC19P017706
  • GC19P017604
  • GC19P017057
  • GC19P017047
  • GC19P017073
  • GC19P017186
  • GC19P016754
  • GC19P017213
  • GC19P017682
  • GC19P017696
  • GC19P018278

Summaries for MYO9B Gene

Entrez Gene Summary for MYO9B Gene

  • This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for MYO9B Gene

MYO9B (Myosin IXB) is a Protein Coding gene. Diseases associated with MYO9B include Celiac Disease 4 and Celiac Disease. Among its related pathways are Immune System and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include protein homodimerization activity and GTPase activator activity. An important paralog of this gene is MYO9A.

UniProtKB/Swiss-Prot for MYO9B Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:9490638, PubMed:26529257). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257).

Gene Wiki entry for MYO9B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO9B Gene

Genomics for MYO9B Gene

Regulatory Elements for MYO9B Gene

Enhancers for MYO9B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F017106 1.7 FANTOM5 Ensembl ENCODE 30.3 +33.4 33414 4.4 HDGF ZFP64 SIN3A ZNF2 ZNF207 FOS JUNB REST TBX21 SMARCB1 ENSG00000268743 ENSG00000269578 C19orf44 ENSG00000267904 ENSG00000268087 SIN3B MYO9B MED26 MVB12A SMIM7
GH19F017087 1.6 FANTOM5 Ensembl ENCODE 31.3 +14.6 14609 4.8 ZFP64 ARID4B SIN3A RAD21 THRB RARA EGR1 SCRT2 CREM THAP11 MYO9B HAUS8 C19orf44 FAM129C MED26 ENSG00000269066 GC19M017078
GH19F017072 1.6 FANTOM5 ENCODE 18.3 +1.5 1476 8.6 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000268743 MYO9B SIN3B ENSG00000269578 ENSG00000267904 HAUS8 ENSG00000268087 PLVAP CPAMD8 ANO8
GH19F017122 1.6 FANTOM5 Ensembl ENCODE 13.2 +49.6 49562 5.6 HDGF PKNOX1 ATF1 CREB3L1 WRNIP1 SIN3A ZNF2 ZNF121 GLIS2 ZNF766 MYO9B AP1M1 HAUS8 MED26 GC19M017123 GC19P019202
GH19F017138 1.6 FANTOM5 Ensembl ENCODE 12.8 +63.3 63298 1.4 ARNT ARID4B ZNF2 YY1 ZNF121 FOS SP5 JUNB NCOA1 ZNF623 MYO9B HAUS8 FAM129C GC19M017123 ENSG00000268056
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYO9B on UCSC Golden Path with GeneCards custom track

Promoters for MYO9B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001647050 121 3001 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207

Genomic Location for MYO9B Gene

Chromosome:
19
Start:
17,075,779 bp from pter
End:
17,215,277 bp from pter
Size:
139,499 bases
Orientation:
Plus strand

Genomic View for MYO9B Gene

Genes around MYO9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO9B Gene

Proteins for MYO9B Gene

  • Protein details for MYO9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13459-MYO9B_HUMAN
    Recommended name:
    Unconventional myosin-IXb
    Protein Accession:
    Q13459
    Secondary Accessions:
    • O75314
    • Q9NUJ2
    • Q9UHN0

    Protein attributes for MYO9B Gene

    Size:
    2157 amino acids
    Molecular mass:
    243401 Da
    Quaternary structure:
    • Interacts (via IQ domains) with CALM (PubMed:9490638). Interacts with RHOA (PubMed:26529257). Interacts (via Rho-GAP domain) with ROBO1; this inhibits the interaction with RHOA and the stimulation of RHOA GTPase activity, and thereby increases the levels of active RHOA (PubMed:26529257).
    SequenceCaution:
    • Sequence=AAC50402.1; Type=Miscellaneous discrepancy; Note=The C-terminal sequence from position 1917 onwards appears to be not correctly spliced.; Evidence={ECO:0000305}; Sequence=BAA92132.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MYO9B Gene

    Alternative splice isoforms for MYO9B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO9B Gene

Post-translational modifications for MYO9B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYO9B Gene

Domains & Families for MYO9B Gene

Gene Families for MYO9B Gene

Suggested Antigen Peptide Sequences for MYO9B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13459

UniProtKB/Swiss-Prot:

MYO9B_HUMAN :
  • Contains 4 IQ domains.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • Contains 4 IQ domains.
  • Contains 1 myosin motor domain.
  • Contains 1 Ras-associating domain.
  • Contains 1 Rho-GAP domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with MYO9B: view

Function for MYO9B Gene

Molecular function for MYO9B Gene

GENATLAS Biochemistry:
myosin IXB,229kDa,unconventional,apparently non filamentous,ortholog of rat myosin myr5,mostly expressed in peripheral blood lymphocytes
UniProtKB/Swiss-Prot Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:9490638, PubMed:26529257). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257).

Gene Ontology (GO) - Molecular Function for MYO9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000146 microfilament motor activity IDA 9490638
GO:0000166 nucleotide binding IEA --
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA,IDA 9490638
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with MYO9B: view
genes like me logo Genes that share phenotypes with MYO9B: view

Animal Models for MYO9B Gene

MGI Knock Outs for MYO9B:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYO9B Gene

Localization for MYO9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO9B Gene

Cytoplasm, cell cortex. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=In undifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localization is cytoplasmic with the highest levels in the perinuclear region. {ECO:0000269 PubMed:8907710}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYO9B gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MYO9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 8907710
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005884 actin filament IDA 8907710
GO:0005938 cell cortex IEA,IDA 8907710
genes like me logo Genes that share ontologies with MYO9B: view

Pathways & Interactions for MYO9B Gene

genes like me logo Genes that share pathways with MYO9B: view

Gene Ontology (GO) - Biological Process for MYO9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007266 Rho protein signal transduction IC 9490638
GO:0030048 actin filament-based movement TAS 8907710
GO:0032011 NOT ARF protein signal transduction IDA 15644318
GO:0035023 regulation of Rho protein signal transduction IMP 26529257
genes like me logo Genes that share ontologies with MYO9B: view

No data available for SIGNOR curated interactions for MYO9B Gene

Drugs & Compounds for MYO9B Gene

(2) Drugs for MYO9B Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(4) Additional Compounds for MYO9B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with MYO9B: view

Transcripts for MYO9B Gene

Unigene Clusters for MYO9B Gene

Myosin IXB:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO9B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20:
SP21:

ExUns: 19b ^