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Aliases for MYO9B Gene

Aliases for MYO9B Gene

  • Myosin IXB 2 3 5
  • Unconventional Myosin-9b 3 4
  • MYR5 3 4
  • Unconventional Myosin IXb 3
  • Myosin-IXb 3
  • CELIAC4 3

External Ids for MYO9B Gene

Previous HGNC Symbols for MYO9B Gene

  • CELIAC4

Previous GeneCards Identifiers for MYO9B Gene

  • GC19P017706
  • GC19P017604
  • GC19P017057
  • GC19P017047
  • GC19P017073
  • GC19P017186
  • GC19P016754
  • GC19P017213
  • GC19P017682

Summaries for MYO9B Gene

Entrez Gene Summary for MYO9B Gene

  • This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for MYO9B Gene

MYO9B (Myosin IXB) is a Protein Coding gene. Diseases associated with MYO9B include Celiac Disease 4 and Celiac Disease. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and ERK Signaling. GO annotations related to this gene include protein homodimerization activity and GTPase activator activity. An important paralog of this gene is MYO7B.

UniProtKB/Swiss-Prot for MYO9B Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activating protein on Rho.

Gene Wiki entry for MYO9B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO9B Gene

Genomics for MYO9B Gene

Regulatory Elements for MYO9B Gene

Enhancers for MYO9B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MYO9B on UCSC Golden Path with GeneCards custom track

Promoters for MYO9B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYO9B on UCSC Golden Path with GeneCards custom track

Genomic Location for MYO9B Gene

Chromosome:
19
Start:
17,075,779 bp from pter
End:
17,215,277 bp from pter
Size:
139,499 bases
Orientation:
Plus strand

Genomic View for MYO9B Gene

Genes around MYO9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO9B Gene

Proteins for MYO9B Gene

  • Protein details for MYO9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13459-MYO9B_HUMAN
    Recommended name:
    Unconventional myosin-IXb
    Protein Accession:
    Q13459
    Secondary Accessions:
    • O75314
    • Q9NUJ2
    • Q9UHN0

    Protein attributes for MYO9B Gene

    Size:
    2157 amino acids
    Molecular mass:
    243401 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC50402.1; Type=Miscellaneous discrepancy; Note=The C-terminal sequence from position 1917 onwards appears to be not correctly spliced.; Evidence={ECO:0000305}; Sequence=BAA92132.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MYO9B Gene

    Alternative splice isoforms for MYO9B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO9B Gene

Proteomics data for MYO9B Gene at MOPED

Post-translational modifications for MYO9B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYO9B Gene

Domains & Families for MYO9B Gene

Gene Families for MYO9B Gene

Suggested Antigen Peptide Sequences for MYO9B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13459

UniProtKB/Swiss-Prot:

MYO9B_HUMAN :
  • Contains 4 IQ domains.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • Contains 4 IQ domains.
  • Contains 1 myosin motor domain.
  • Contains 1 Ras-associating domain.
  • Contains 1 Rho-GAP domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with MYO9B: view

Function for MYO9B Gene

Molecular function for MYO9B Gene

GENATLAS Biochemistry:
myosin IXB,229kDa,unconventional,apparently non filamentous,ortholog of rat myosin myr5,mostly expressed in peripheral blood lymphocytes
UniProtKB/Swiss-Prot Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activating protein on Rho.

Gene Ontology (GO) - Molecular Function for MYO9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000146 microfilament motor activity IDA 9490638
GO:0003779 actin binding IDA 9490638
GO:0005515 protein binding IEA,IPI 15644318
GO:0008270 zinc ion binding IEA --
GO:0030898 actin-dependent ATPase activity IEA --
genes like me logo Genes that share ontologies with MYO9B: view
genes like me logo Genes that share phenotypes with MYO9B: view

Animal Models for MYO9B Gene

MGI Knock Outs for MYO9B:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYO9B Gene

Localization for MYO9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO9B Gene

Cytoplasm, cell cortex. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=In undifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localization is cytoplasmic with the highest levels in the perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO9B Gene COMPARTMENTS Subcellular localization image for MYO9B gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MYO9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MYO9B: view

Pathways & Interactions for MYO9B Gene

genes like me logo Genes that share pathways with MYO9B: view

Gene Ontology (GO) - Biological Process for MYO9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0032011 NOT ARF protein signal transduction IDA 15644318
GO:0035023 regulation of Rho protein signal transduction IMP 26529257
genes like me logo Genes that share ontologies with MYO9B: view

No data available for SIGNOR curated interactions for MYO9B Gene

Drugs & Compounds for MYO9B Gene

(2) Drugs for MYO9B Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(4) Additional Compounds for MYO9B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with MYO9B: view

Transcripts for MYO9B Gene

Unigene Clusters for MYO9B Gene

Myosin IXB:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYO9B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20:
SP21:

ExUns: 19b ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28 ^ 29a · 29b · 29c ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33a · 33b ·
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

ExUns: 33c ^ 34a · 34b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16: -
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for MYO9B Gene

GeneLoc Exon Structure for
MYO9B
ECgene alternative splicing isoforms for
MYO9B

Expression for MYO9B Gene

mRNA expression in normal human tissues for MYO9B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYO9B Gene

This gene is overexpressed in Whole Blood (x4.7).

Protein differential expression in normal tissues from HIPED for MYO9B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYO9B Gene



SOURCE GeneReport for Unigene cluster for MYO9B Gene Hs.123198

mRNA Expression by UniProt/SwissProt for MYO9B Gene

Q13459-MYO9B_HUMAN
Tissue specificity: Expressed predominantly in peripheral blood leukocytes and at lower levels, in thymus, spleen, testis, prostate, ovary, brain, small intestine and lung.
genes like me logo Genes that share expression patterns with MYO9B: view

Protein tissue co-expression partners for MYO9B Gene

Primer Products

Orthologs for MYO9B Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO9B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYO9B 35
  • 86.07 (n)
  • 86.58 (a)
MYO9B 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO9B 35
  • 86.53 (n)
  • 88.62 (a)
MYO9B 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo9b 35
  • 82.13 (n)
  • 85.34 (a)
Myo9b 16
Myo9b 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYO9B 35
  • 99.38 (n)
  • 99.44 (a)
MYO9B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myo9b 35
  • 82.33 (n)
  • 85.57 (a)
oppossum
(Monodelphis domestica)
Mammalia MYO9B 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYO9B 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYO9B 35
  • 67.29 (n)
  • 71.02 (a)
MYO9B 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo9b 35
  • 68.66 (n)
  • 77 (a)
Str.3184 35
zebrafish
(Danio rerio)
Actinopterygii myo9b 35
  • 59.01 (n)
  • 56.21 (a)
myo9b 36
  • 41 (a)
OneToMany
MYO9B (1 of 3) 36
  • 51 (a)
OneToMany
MYO9B (3 of 3) 36
  • 67 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3188 35
worm
(Caenorhabditis elegans)
Secernentea hum-7 37
  • 42 (a)
hum-7 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for MYO9B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYO9B Gene

ENSEMBL:
Gene Tree for MYO9B (if available)
TreeFam:
Gene Tree for MYO9B (if available)

Paralogs for MYO9B Gene

Paralogs for MYO9B Gene

genes like me logo Genes that share paralogs with MYO9B: view

Variants for MYO9B Gene

Sequence variations from dbSNP and Humsavar for MYO9B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7256138 -- 17,132,568(+) ctgtc(A/G)cccag intron-variant
rs7256689 -- 17,163,083(+) CAGCT(G/T)CAGTA nc-transcript-variant, reference, synonymous-codon
rs7256842 -- 17,088,991(+) ACTTT(C/T)TGAAA intron-variant
rs7257000 -- 17,089,119(+) GCCAT(C/T)TTATG intron-variant
rs7257021 -- 17,089,163(+) GGTCT(C/T)TAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO9B Gene

Variant ID Type Subtype PubMed ID
nsv2427 CNV Insertion 18451855
esv29036 CNV Gain 19812545
nsv821248 CNV Deletion 20802225
esv2718272 CNV Deletion 23290073
nsv828468 CNV Gain 20364138
esv2658735 CNV Deletion 23128226
dgv3756n71 CNV Loss 21882294
nsv458373 CNV Loss 19166990
dgv3757n71 CNV Loss 21882294
dgv3758n71 CNV Loss 21882294
nsv911182 CNV Loss 21882294
nsv470129 CNV Loss 18288195
nsv911184 CNV Loss 21882294
nsv911185 CNV Loss 21882294
esv2718274 CNV Deletion 23290073
nsv911186 CNV Gain 21882294

Variation tolerance for MYO9B Gene

Residual Variation Intolerance Score: 7.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.76; 66.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO9B Gene

Human Gene Mutation Database (HGMD)
MYO9B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO9B Gene

Disorders for MYO9B Gene

MalaCards: The human disease database

(8) MalaCards diseases for MYO9B Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
celiac disease 4
  • celiac disease, susceptibility to, 4
celiac disease
  • celiac sprue
ulcerative colitis
  • left-sided ulcerative colitis
refractory celiac disease
  • refractory cd
dermatitis herpetiformis
  • dermatitis herpetiformis [dup]
- elite association - COSMIC cancer census association via MalaCards
Search MYO9B in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MYO9B_HUMAN
  • Celiac disease 4 (CELIAC4) [MIM:609753]: A multifactorial, chronic disorder of the small intestine caused by intolerance to gluten. It is characterized by immune-mediated enteropathy associated with failed intestinal absorption, and malnutrition. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for MYO9B

Genetic Association Database (GAD)
MYO9B
Human Genome Epidemiology (HuGE) Navigator
MYO9B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO9B
genes like me logo Genes that share disorders with MYO9B: view

No data available for Genatlas for MYO9B Gene

Publications for MYO9B Gene

  1. Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. (PMID: 16282976) Monsuur A.J. … Wijmenga C. (Nat. Genet. 2005) 3 4 23 48 67
  2. Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1. (PMID: 9226381) BAohler M. … Olsen A.S. (Genomics 1997) 2 3 23
  3. Association analysis of myosin IXB and type 1 diabetes. (PMID: 20303373) Persengiev S. … Alizadeh B.Z. (Hum. Immunol. 2010) 3 23
  4. MYO9B polymorphisms in multiple sclerosis. (PMID: 19142207) Kemppinen A. … Saarela J. (Eur. J. Hum. Genet. 2009) 3 23
  5. Association between genetic variants in myosin IXB and Crohn's disease. (PMID: 19235913) Cooney R. … Jewell D.P. (Inflamm. Bowel Dis. 2009) 3 23

Products for MYO9B Gene