MYO9B Gene
protein-coding GIFtS: 63
GCID: GC19P017186
|
|
myosin IXB
(Previous symbol: CELIAC4)
| |
Aliases
for MYO9B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Myosin IXB1 2 | | Myosin-IXb1 | | CELIAC41 2 5 | | Unconventional Myosin IXb2 | | MYR52 3 5 | | Unconventional Myosin-IXb2 | | Unconventional Myosin-9b2 3 | | |
Export aliases for MYO9B gene to outside databasesPrevious GC identifers: GC19P017706 GC19P017604 GC19P017057 GC19P017047 GC19P017073 GC19P016754 |
Summaries
for MYO9B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MYO9B:
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The proteinrepresents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Theprotein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The proteincomplex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. Theprotein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerativecolitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Dec 2011)
UniProtKB/Swiss-Prot: MYO9B_HUMAN, Q13459Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellularmovements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in theabsence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPaseactivating protein on Rho
Gene Wiki entry for MYO9B
|
Genomic Views
for MYO9B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MYO9B gene promoter:
Elk-1 GATA-3 RREB-1 GCNF MIF-1 GATA-1 AREB6 GCNF-1 Cart-1 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MYO9B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYO9B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.1 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.1MYO9B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P017186: view genomic region
(about GC identifiers)
Start:
|
17,186,591 bp from pter |
End:
|
17,324,104 bp from pter |
Size:
|
137,514 bases |
Orientation:
|
plus strand |
|
Proteins
for MYO9B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MYO9B_HUMAN, Q13459 (See
protein sequence)Recommended Name: Unconventional myosin-IXb Size: 2157 amino acids; 243401 Da
Subcellular location: Cytoplasm, cell cortex. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Inundifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localizationis cytoplasmic with the highest levels in the perinuclear region
Caution: Represents a unconventional myosin. This protein should not be confused with the conventional myosin-9 (MYH9)
Sequence caution: Sequence=AAC50402.1; Type=Miscellaneous discrepancy; Note=The C-terminal sequence from position 1917onwards appears to be not correctly spliced; Sequence=BAA92132.1; Type=Erroneous initiation; Note=TranslationN-terminally extended;
Secondary accessions: O75314 Q9NUJ2 Q9UHN0Alternative splicing: 2 isoforms: Q13459-1 Q13459-2 Explore the universe of human proteins at neXtProt for MYO9B: NX_Q13459
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13459
MYO9B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001123537.1 NP_004136.2
ENSEMBL proteins: ENSP00000380444 Reactome Protein details: Q13459
Human Recombinant Protein Products for MYO9B:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
MYO9B for ontologies About GeneDecksing
MYO9B Antibody Products:
Assay Products for MYO9B: |
Protein
Domains /
Families
for MYO9B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MYO9B for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q13459ProtoNet protein and cluster: Q13459 3 Blocks protein families: IPB000048 IQ calmodulin-binding region IPB000159 RA domain IPB000198 RhoGAP domain
UniProtKB/Swiss-Prot: MYO9B_HUMAN, Q13459Similarity: Contains 4 IQ domainsSimilarity: Contains 1 myosin head-like domainSimilarity: Contains 1 phorbol-ester/DAG-type zinc fingerSimilarity: Contains 1 Ras-associating domainSimilarity: Contains 1 Rho-GAP domain |
Function
for MYO9B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MYO9B_HUMAN, Q13459Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellularmovements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in theabsence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPaseactivating protein on Rho Genatlas biochemistry entry for MYO9B:myosin IXB,229kDa,unconventional,apparently non filamentous,ortholog of rat myosin myr5,mostly expressed in peripheralblood lymphocytes
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table
MYO9B for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for MYO9B:
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Myo9b):
MYO9B for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Myo9btm1.2Bah for MYO9B
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYO9B (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYO9B (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MYO9B (NM_004145) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYO9B | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MYO9B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO9B |
|
Pathways & Interactions
for MYO9B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of actin dynamics for phagocytic cup formation | | | 2 | PAK Pathway | | | 3 | G-protein signaling_RhoA regulation pathway | | | 4 | Immune System | | | 5 | Fc-GammaR-Mediated Phagocytosis in Macrophages | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for MYO9B
5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYO9B (see all 11)
1  GeneGo (Thomson Reuters) Pathway for MYO9B
1  BioSystems Pathway for MYO9B
5/8 
Reactome Pathways for MYO9B (see all 8)
MYO9B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYO9B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/56 Interacting proteins for MYO9B (Q134591, 2, 3 ENSP000003804444) via UniProtKB, MINT, STRING, and/or I2D (see all 56)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
MYO9B for ontologies About GeneDecksing
|
Drugs & Compounds
for MYO9B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MYO9B for compounds About GeneDecksing
 Browse Tocris compounds for MYO9B
10/844 HMDB Compounds for MYO9B (see all 844) About this table
1 Novoseek chemical compound relationship for MYO9B gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| atp |
12 |
3 |
9490638 (1), 16338935 (1) |
Search CenterWatch for drugs/clinical trials and news about MYO9B
|
Transcripts
for MYO9B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MYO9B gene (2 alternative transcripts): NM_001130065.1 NM_004145.3 Unigene Clusters for MYO9B: Myosin IXB Hs.123198 [show with all ESTs], Hs.736097 [show with all ESTs]Unigene Representative Sequences: NM_001130065, BM4789811 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000397274(uc002nfi.3 uc010eak.3 uc002nfj.1 uc002nfl.1 uc002nfm.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYO9B (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYO9B (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MYO9B (NM_004145) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYO9B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MYO9B |
Additional cDNA sequence: AF020267.1 16 DOTS entries: DT.215361 DT.100749977 DT.75178025 DT.100028946 DT.100749976 DT.121456810 DT.100749975 DT.92470506 DT.100749693 DT.99997649 DT.92470455 DT.92470538 DT.95161067 DT.40255406 DT.95104270 DT.99960894 24/310 AceView cDNA sequences (see all 310): CF129942 AI332358 BM710109 AA331212 BQ678028 BU521307 CR598001 BM458746 N53795 CF138966 AI347172 AA359477 BQ061979 NM_004145 BQ574144 BM716886 BF923290 AA836261 BQ440900 BM671278 BU181860 CA428840 BU738472 AA338660
GeneLoc Exon Structure
5/21 Alternative Splicing Database (ASD) splice patterns (SP) for MYO9B (see all 21) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19b | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | · | 27c | ^ | 28 | ^ | 29a | · | 29b | · | 29c | ^ | 30a | · | 30b | ^ | 31 | ^ | 32a | · | 32b | ^ | 33a | · | 33b | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 33c | ^ | 34a | · | 34b |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for MYO9B
|
Expression
for MYO9B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MYO9B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATAAAAAG
About this image
See MYO9B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYO9B
SOURCE GeneReport for Unigene clusters: Hs.123198 Hs.736097
UniProtKB/Swiss-Prot: MYO9B_HUMAN, Q13459Tissue specificity: Expressed predominantly in peripheral blood leukocytes and at lower levels, in thymus, spleen,testis, prostate, ovary, brain, small intestine and lung
SABiosciences Custom PCR Arrays for MYO9B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYO9B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYO9B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYO9B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYO9B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO9B |
Orthologs
for MYO9B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MYO9B gene from 6/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MYO9B1 |
myosin IXB |
67.17(n)
71.01(a) |
|
420135 XM_418252.3 XP_418252.3 |
lizard
(Anolis carolinensis) |
Reptilia |
MYO9B6 |
-- |
39(a) |
possible ortholog |
GL344263.1(38260-69329) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ079542.12 |
-- |
77.37(n) |
|
BJ079542.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
myo9b1 |
myosin IXb |
58.44(n)
55.64(a) |
|
560956 XM_684354.5 XP_689446.4 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
29(a) |
1 → many |
Group6.21(123702-133650) |
worm
(Caenorhabditis elegans) |
Secernentea |
hum-73 |
myosin |
42(a) |
|
I(585863-607574) -- |
ENSEMBL Gene Tree for MYO9B (if available)
TreeFam Gene Tree for MYO9B (if available) |
Paralogs
for MYO9B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MYO9B gene
- MYO3A2 MYO9A2 MYO5C2 MYO102 MYO15A2 MYO7A2 MYO162 MYO5A2
- MYO7B2 MYO5B2 MYO62 MYO3B2
7 SIMAP similar genes for MYO9B using alignment to 10 protein entries: MYO9B_HUMAN (see all proteins):MYO9B variant protein MYO9A ARHGAP12 MYO1D MYO5B CHN1
MYO1F
MYO9B for paralogs About GeneDecksing
|
Genomic Variants
for MYO9B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MYO9B (17186591 - 17324104 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MYO9B
1 CNV: 30072
1 Indel: 67485
Human Gene Mutation Database (HGMD): MYO9B
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYO9B |
|
Disorders
/ Diseases
for MYO9B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MYO9B for disorders About GeneDecksing
OMIM gene information: 602129
OMIM disorders: 609753
UniProtKB/Swiss-Prot: MYO9B_HUMAN, Q13459
Genetic variation in MYO9B is the cause of susceptibility to celiac disease type 4 (CELIAC4) [MIM:609753]. Itis a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. Itis characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after theingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized inchildren by malabsorption and failure to thrive
10  diseases for MYO9B: About MalaCardsulcerative colitis celiac disease inflammatory bowel disease dermatitis herpetiformis
multiple sclerosis dermatitis crohn's disease spasticity
schizophrenia prostatitis
2 diseases from the University of Copenhagen DISEASES database for MYO9B:Celiac disease Inflammatory bowel disease 3 Novoseek disease relationships for MYO9B gene About this table
Human Genome Epidemiology (HuGE) Navigator: MYO9B (23 documents)
Export disorders for MYO9B gene to outside databases
|
Publications
for MYO9B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MYO9B gene, integrated from 9 sources (see all 67):
(articles sorted by number of sources associating them with MYO9B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human myosin-IXb is a mechanochemically active motor and a GAP for rho. (PubMed id 9490638)1, 2, 9 Post P.L.... Mooseker M.S. (1998)
- Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail. (PubMed id 8907710)1, 2, 9 Wirth J.A.... Mooseker M.S. (1996)
- Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1. (PubMed id 9226381)1, 3, 9 Bahler M....Olsen A.S. (1997)
- Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. (PubMed id 16282976)1, 2, 9 Monsuur A.J....Wijmenga C. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Genetic variation in myosin IXB is associated with ulcerative colitis. (PubMed id 17087940)1, 9 van Bodegraven A.A....van Heel D.A. (2006)
- Association between genetic variants in myosin IXB and Crohn's disease. (PubMed id 19235913)1, 9 Cooney R....Jewell D.P. (2009)
- Lack of association of MYO9B genetic variants with coeliac disease in a British cohort. (PubMed id 16423886)1, 9 Hunt K.A....van Heel D.A. (2006)
- Association analysis of myosin IXB and type 1 diabete s. (PubMed id 20303373)1, 9 Persengiev S....Alizadeh B.Z. (2010)
- Association of MYO9B haplotype with type 1 diabetes. (PubMed id 18361936)1, 9 Santiago J.L....Urcelay E. (2008)
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External Searches for MYO9B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing MYO9B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing MYO9B gene
(According to HUGE)
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Specialized Databases showing MYO9B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for MYO9B | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/MYO9B |
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About This Section
| Patent Information for MYO9B gene:
Search GeneIP for patents involving MYO9B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MYO9B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for MYO9B | | OriGene shRNA RFP for MYO9B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYO9B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYO9B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MYO9B | | OriGene 3'-UTR Clone for MYO9B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYO9B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYO9B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MYO9B | | OriGene Custom Protein Services for MYO9B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MYO9B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYO9B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYO9B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYO9B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYO9B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYO9B |
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| | | | Search Tocris compounds for MYO9B |
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 | | | MYO9B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO9B |
|  |  |  |  | | | | ThermoFisher Antibodies for MYO9B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MYO9B |
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