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Aliases for MYO9A Gene

Aliases for MYO9A Gene

  • Myosin IXA 2 3
  • Unconventional Myosin-9a 3 4
  • Unconventional Myosin-IXa 3
  • Myosin-IXa 3
  • MYR7 4

External Ids for MYO9A Gene

Previous GeneCards Identifiers for MYO9A Gene

  • GC15M067913
  • GC15M065216
  • GC15M069694
  • GC15M069834
  • GC15M069905
  • GC15M072114
  • GC15M048948

Summaries for MYO9A Gene

Entrez Gene Summary for MYO9A Gene

  • This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. [provided by RefSeq, Dec 2011]

GeneCards Summary for MYO9A Gene

MYO9A (Myosin IXA) is a Protein Coding gene. Diseases associated with MYO9A include bardet-biedl syndrome. Among its related pathways are RhoGDI Pathway and Signaling by GPCR. GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYO7A.

UniProtKB/Swiss-Prot for MYO9A Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho activity in neurons, has a role in the regulation of neuronal morphology and function (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO9A Gene

Genomics for MYO9A Gene

Regulatory Elements for MYO9A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MYO9A Gene

Start:
71,822,289 bp from pter
End:
72,118,577 bp from pter
Size:
296,289 bases
Orientation:
Minus strand

Genomic View for MYO9A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYO9A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO9A Gene

Proteins for MYO9A Gene

  • Protein details for MYO9A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B2RTY4-MYO9A_HUMAN
    Recommended name:
    Unconventional myosin-IXa
    Protein Accession:
    B2RTY4
    Secondary Accessions:
    • B0I1T5
    • C9IYB3
    • C9JA86
    • Q14787
    • Q3YLD7
    • Q3YLD8
    • Q6P986
    • Q9H8T5
    • Q9NTG2
    • Q9NUY2
    • Q9UEP3
    • Q9UNJ2

    Protein attributes for MYO9A Gene

    Size:
    2548 amino acids
    Molecular mass:
    292706 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91979.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14517.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MYO9A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO9A Gene

Proteomics data for MYO9A Gene at MOPED

Post-translational modifications for MYO9A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYO9A Gene

Domains for MYO9A Gene

Gene Families for MYO9A Gene

HGNC:
  • MYOIX :Myosins / Myosin superfamily : Class IX

Suggested Antigen Peptide Sequences for MYO9A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B2RTY4

UniProtKB/Swiss-Prot:

MYO9A_HUMAN :
  • B2RTY4
Domain:
  • Contains 5 IQ domains.
  • Contains 1 myosin motor domain.
  • Contains 1 Ras-associating domain.
  • Contains 1 Rho-GAP domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with MYO9A: view

Function for MYO9A Gene

Molecular function for MYO9A Gene

GENATLAS Biochemistry:
unconventional myosin IXA,widely expressed,located in the BBS4 region
UniProtKB/Swiss-Prot Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho activity in neurons, has a role in the regulation of neuronal morphology and function (By similarity).

Gene Ontology (GO) - Molecular Function for MYO9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 15644318
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYO9A: view

Phenotypes for MYO9A Gene

GenomeRNAi human phenotypes for MYO9A:
genes like me logo Genes that share phenotypes with MYO9A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MYO9A Gene

Localization for MYO9A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO9A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO9A Gene COMPARTMENTS Subcellular localization image for MYO9A gene
Compartment Confidence
cytoskeleton 5
cytosol 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MYO9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0016021 integral component of membrane IEA --
GO:0016459 myosin complex --
GO:0016461 unconventional myosin complex NAS 8022818
genes like me logo Genes that share ontologies with MYO9A: view

Pathways for MYO9A Gene

genes like me logo Genes that share pathways with MYO9A: view

Pathways by source for MYO9A Gene

Gene Ontology (GO) - Biological Process for MYO9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007601 visual perception TAS 10409426
GO:0008152 metabolic process IEA --
GO:0035556 intracellular signal transduction --
genes like me logo Genes that share ontologies with MYO9A: view

Compounds for MYO9A Gene

(843) HMDB Compounds for MYO9A Gene

Compound Synonyms Cas Number PubMed IDs
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available
DG(14:0/16:1(9Z)/0:0)
  • DG(30:1)
Not Available
genes like me logo Genes that share compounds with MYO9A: view

Transcripts for MYO9A Gene

Unigene Clusters for MYO9A Gene

Myosin IXA:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYO9A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO9A Gene

No ASD Table

Relevant External Links for MYO9A Gene

GeneLoc Exon Structure for
MYO9A
ECgene alternative splicing isoforms for
MYO9A

Expression for MYO9A Gene

mRNA expression in normal human tissues for MYO9A Gene

Protein differential expression in normal tissues for MYO9A Gene

This gene is overexpressed in Fetal Liver (49.5) and Testis (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYO9A Gene

SOURCE GeneReport for Unigene cluster for MYO9A Gene Hs.546268

mRNA Expression by UniProt/SwissProt for MYO9A Gene

B2RTY4-MYO9A_HUMAN
Tissue specificity: Found to be expressed in testis and placenta, and at lower levels in all the examined tissues with the exception of liver. Isoform 5 was found in leukocytes but not in brain, retina or testis.
genes like me logo Genes that share expressions with MYO9A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Expression partners for MYO9A Gene

Orthologs for MYO9A Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO9A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC515330 35
  • 90.33 (n)
  • 88.81 (a)
MYO9A 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO9A 35
  • 91.88 (n)
  • 92.3 (a)
MYO9A 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo9a 35
  • 87.31 (n)
  • 87.88 (a)
Myo9a 16
Myo9a 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYO9A 35
  • 99.56 (n)
  • 99.45 (a)
MYO9A 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myo9a 35
  • 87.06 (n)
  • 87.7 (a)
oppossum
(Monodelphis domestica)
Mammalia MYO9A 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYO9A 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYO9A 35
  • 71.17 (n)
  • 75.57 (a)
MYO9A 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYO9A 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo9a 35
  • 63.22 (n)
  • 64.78 (a)
zebrafish
(Danio rerio)
Actinopterygii myo9aa 35
  • 63.96 (n)
  • 67.56 (a)
myo9aa 36
  • 64 (a)
OneToMany
myo9ab 36
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hum-7 37
  • 49 (a)
hum-7 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for MYO9A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYO9A Gene

ENSEMBL:
Gene Tree for MYO9A (if available)
TreeFam:
Gene Tree for MYO9A (if available)

Paralogs for MYO9A Gene

Paralogs for MYO9A Gene

genes like me logo Genes that share paralogs with MYO9A: view

Variants for MYO9A Gene

Sequence variations from dbSNP and Humsavar for MYO9A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs8178 -- 71,822,406(-) AGATA(C/T)CATCT utr-variant-3-prime
rs8557 -- 71,823,392(-) AGAGC(A/G)CTTAC utr-variant-3-prime
rs8747 -- 71,823,200(-) AAGAA(G/T)AAAGG utr-variant-3-prime
rs9120 -- 71,823,422(-) CCCCA(C/T)CTTCT utr-variant-3-prime
rs748471 -- 71,973,833(+) GAGAA(A/G)CGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO9A Gene

Variant ID Type Subtype PubMed ID
nsv904334 CNV Gain 21882294
esv2531029 CNV Deletion 19546169
nsv516871 CNV Gain+Loss 19592680
nsv904336 CNV Loss 21882294
nsv457195 CNV Loss 19166990
esv2749858 CNV Deletion 23290073
esv2749859 CNV Deletion 23290073
esv2331045 CNV Deletion 18987734
esv2749860 CNV Deletion 23290073
esv2749861 CNV Deletion 23290073
nsv510405 CNV Loss 20534489
esv2672608 CNV Deletion 23128226
nsv457199 CNV Loss 19166990
nsv457200 CNV Loss 19166990
nsv457201 CNV Loss 19166990
esv2656527 CNV Deletion 23128226
nsv833051 CNV Gain 17160897
esv28860 CNV Gain 19812545
nsv904337 CNV Loss 21882294
nsv510665 CNV Loss 20534489
nsv512406 CNV Loss 21212237
nsv821198 CNV Deletion 20802225
esv2749862 CNV Deletion 23290073
nsv511557 CNV Loss 21212237

Relevant External Links for MYO9A Gene

HapMap Linkage Disequilibrium report
MYO9A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO9A Gene

Disorders for MYO9A Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MYO9A Gene in MalaCards »

(1) Diseases for MYO9A Gene including...

Relevant External Links for MYO9A

Genetic Association Database (GAD)
MYO9A
Human Genome Epidemiology (HuGE) Navigator
MYO9A
genes like me logo Genes that share disorders with MYO9A: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MYO9A Gene

Publications for MYO9A Gene

  1. The cloning and developmental expression of unconventional myosin IXA (MYO9A) a gene in the Bardet-Biedl syndrome (BBS4) region at chromosome 15q22-q23. (PMID: 10409426) Gorman S.W. … Duhl D.M. (Genomics 1999) 2 3 4 23
  2. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. (PMID: 8022818) Bement W.M. … Mooseker M.S. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Non-EST based prediction of exon skipping and intron retention events using Pfam information. (PMID: 16204458) Hiller M. … Backofen R. (Nucleic Acids Res. 2005) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for MYO9A Gene

Sources for MYO9A Gene

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