Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MYO9A Gene

protein-coding   GIFtS: 55
GCID: GC15M072114

Myosin IXA

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Myosin IXA1 2
Unconventional Myosin-9a2 3
myosin-IXa2
Unconventional Myosin-IXa2
MYR73

External Ids:    HGNC: 76081   Entrez Gene: 46492   Ensembl: ENSG000000669337   OMIM: 6048755   UniProtKB: B2RTY43   

Export aliases for MYO9A gene to outside databases

Previous GC identifers: GC15M067913 GC15M065216 GC15M069694 GC15M069834 GC15M069905 GC15M048948


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MYO9A Gene:
This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should
not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic
domains of conventional myosins and are further distinguished from class members by their tail domains. They
function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome.
(provided by RefSeq, Dec 2011)

GeneCards Summary for MYO9A Gene:
MYO9A (myosin IXA) is a protein-coding gene. Diseases associated with MYO9A include bardet-biedl syndrome, and spasticity. GO annotations related to this gene include motor activity and actin binding. An important paralog of this gene is MYO3A.

UniProtKB/Swiss-Prot: MYO9A_HUMAN, B2RTY4
Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in
intracellular movements. Regulates Rho activity in neurons, has a role in the regulation of neuronal morphology
and function (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYO9A gene promoter:
         Sp1   SREBP-1c   CUTL1   HNF-1A   SREBP-1b   CREB   SREBP-1a   HNF-1   deltaCREB   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYO9A promoter sequence
   Search Chromatin IP Primers for MYO9A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYO9A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22-q23   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q22-q23

MYO9A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO9A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M072114:  view genomic region     (about GC identifiers)

Start:
72,114,632 bp from pter      End:
72,410,918 bp from pter
Size:
296,287 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MYO9A_HUMAN, B2RTY4 (See protein sequence)
Recommended Name: Unconventional myosin-IXa  
Size: 2548 amino acids; 292706 Da
Caution: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-9
(MYH9)
Sequence caution: Sequence=BAA91979.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14517.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B0I1T5 C9IYB3 C9JA86 Q14787 Q3YLD7 Q3YLD8 Q6P986 Q9H8T5 Q9NTG2 Q9NUY2
Q9UEP3 Q9UNJ2
Alternative splicing: 5 isoforms:  B2RTY4-1   B2RTY4-2   B2RTY4-3   B2RTY4-4   B2RTY4-5   (Lacks the ATP-binding domain which suggests that it cannot interact with actin)

Explore the universe of human proteins at neXtProt for MYO9A: NX_B2RTY4

Explore proteomics data for MYO9A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYO9A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008832.2  
    ENSEMBL proteins: 
     ENSP00000348349   ENSP00000457945   ENSP00000457407   ENSP00000456192   ENSP00000455150  
     ENSP00000454446   ENSP00000457235   ENSP00000454517   ENSP00000456882   ENSP00000399162  
     ENSP00000398250  
    Reactome Protein details: B2RTY4

    MYO9A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MYO9A
    GenScript Custom Purified and Recombinant Proteins Services for MYO9A
    Novus Biologicals MYO9A Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYO9A

    MYO9A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MYO9A
    Novus Biologicals MYO9A Antibodies
    Abcam antibodies for MYO9A
    Cloud-Clone Corp. Antibodies for MYO9A
    Search ThermoFisher Antibodies for MYO9A
    LSBio Antibodies in human, mouse, rat for MYO9A

    MYO9A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MYO9A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYO9A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYO9A
    Cloud-Clone Corp. CLIAs for MYO9A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    MYOIX: Myosins / Myosin superfamily : Class IX

    Selected InterPro protein domains (see all 8):
     IPR008936 Rho_GTPase_activation_prot
     IPR000159 Ras-assoc
     IPR028558 MYO9A
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry B2RTY4

    ProtoNet protein and cluster: B2RTY4

    UniProtKB/Swiss-Prot: MYO9A_HUMAN, B2RTY4
    Similarity: Contains 5 IQ domains
    Similarity: Contains 2 myosin head-like domains
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 Rho-GAP domain


    MYO9A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYO9A_HUMAN, B2RTY4
    Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in
    intracellular movements. Regulates Rho activity in neurons, has a role in the regulation of neuronal morphology
    and function (By similarity)

         Genatlas biochemistry entry for MYO9A:
    unconventional myosin IXA,widely expressed,located in the BBS4 region

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0003779actin binding IEA--
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI15644318
    GO:0005524ATP binding IEA--
         
    MYO9A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MYO9A:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYO9A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYO9A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYO9A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYO9A

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYO9A:
    hsa-let-7c-5p (MIRT051864), hsa-mir-27a-3p (MIRT028717), hsa-let-7a-5p (MIRT052604), hsa-mir-21-5p (MIRT030828), hsa-mir-128-3p (MIRT021993), hsa-mir-615-3p (MIRT040450), hsa-mir-101-3p (MIRT027352)

    Block miRNA regulation of human, mouse, rat MYO9A using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate MYO9A:
    hsa-miR-124 hsa-miR-3658 hsa-miR-186* hsa-miR-3121-3p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidMYO9A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MYO9A
    Predesigned siRNA for gene silencing in human, mouse, rat MYO9A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYO9A

    Clone
    Products:
         
    OriGene clones in human, mouse for MYO9A (see all 5)
    OriGene ORF clones in mouse, rat for MYO9A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYO9A (NM_006901)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYO9A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO9A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MYO9A
    Browse ESI BIO Cell Lines and PureStem Progenitors for MYO9A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO9A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MYO9A_HUMAN, B2RTY4: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0016021integral component of membrane IEA--
    GO:0016459myosin complex ----
    GO:0016461unconventional myosin complex NAS8022818

    MYO9A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MYO9A About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    2Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    3Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    4RhoGDI Pathway
    Fc-GammaR-Mediated Phagocytosis in Macrophages0.33
    RhoGDI Pathway0.33
    5Signaling by GPCR
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYO9A (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    1 Reactome Pathway for MYO9A
        Rho GTPase cycle



    MYO9A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYO9A
    Interactions:

        Search GeneGlobe Interaction Network for MYO9A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYO9A (B2RTY43 ENSP000003483494) via UniProtKB, MINT, STRING, and/or I2D (see all 80)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    PPP2R2BQ000053, ENSP000003365914I2D: score=2 STRING: ENSP00000336591
    CDC42P609533, ENSP000003144584I2D: score=5 STRING: ENSP00000314458
    MYZAPP0CAP13I2D: score=4 
    POLR2MP0CAP23I2D: score=3 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007601visual perception TAS10409426
    GO:0035556intracellular signal transduction ----
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    MYO9A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYO9A

    Selected HMDB Compounds for MYO9A (see all 843)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MYO9A gene: 
    NM_006901.3  

    Unigene Cluster for MYO9A:

    Myosin IXA
    Hs.546268  [show with all ESTs]
    Unigene Representative Sequence: NM_006901
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000356056(uc002atl.4) ENST00000561618 ENST00000568042 ENST00000564571
    ENST00000568481 ENST00000564699 ENST00000563071 ENST00000563542(uc002atn.1)
    ENST00000568781 ENST00000566885(uc010biq.3) ENST00000566744 ENST00000563648
    ENST00000565528 ENST00000567095 ENST00000563925 ENST00000567560(uc002ato.3)
    ENST00000568438 ENST00000569314
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MYO9A using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate MYO9A:
    hsa-miR-124 hsa-miR-3658 hsa-miR-186* hsa-miR-3121-3p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidMYO9A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MYO9A
    Predesigned siRNA for gene silencing in human, mouse, rat MYO9A
    Clone
    Products:
         
    OriGene clones in human, mouse for MYO9A (see all 5)
    OriGene ORF clones in mouse, rat for MYO9A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYO9A (NM_006901)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYO9A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO9A
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MYO9A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYO9A
      QuantiTect SYBR Green Assays in human, mouse, rat MYO9A
      QuantiFast Probe-based Assays in human, mouse, rat MYO9A

    Additional mRNA sequence: 

    AB209841.1 AB290183.1 AF117888.1 AJ001714.1 AK001923.1 AK023306.1 AL137287.1 BC060886.1 
    BC140869.1 BC144683.1 BC150294.1 DQ088983.1 DQ088984.1 L29148.1 

    14 DOTS entries:

    DT.110966  DT.75198560  DT.91643477  DT.101978549  DT.100023347  DT.100786357  DT.205337  DT.40247736 
    DT.100643662  DT.121077420  DT.303809  DT.75104834  DT.75126467  DT.75146265 

    Selected AceView cDNA sequences (see all 131):

    AI769976 CR596085 BP348859 BU507946 BF061835 AA494302 AI636635 CB120828 
    BM724066 AA287851 BP363841 BG118393 AA235795 BM461760 AW294290 AK023306 
    BX363254 AK001923 AU136653 BM680262 L29148 BM724723 AI963943 AI147845 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MYO9A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATATTCTG
    MYO9A Expression
    About this image

    MYO9A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYO9A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546268

    UniProtKB/Swiss-Prot: MYO9A_HUMAN, B2RTY4
    Tissue specificity: Found to be expressed in testis and placenta, and at lower levels in all the examined tissues
    with the exception of liver. Isoform 5 was found in leukocytes but not in brain, retina or testis

        Custom PCR Arrays for MYO9A
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MYO9A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYO9A
    QuantiTect SYBR Green Assays in human, mouse, rat MYO9A
    QuantiFast Probe-based Assays in human, mouse, rat MYO9A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO9A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MYO9A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myo9a1 , 5 myosin IXa1, 5 87.31(n)1
    87.88(a)1
      9 (32.13 cM)5
    2701631  NM_173018.21  NP_766606.21 
     597508965 
    chicken
    (Gallus gallus)
    Aves MYO9A1 myosin IXA 71.17(n)
    75.57(a)
      101748321  XM_004943639.1  XP_004943696.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYO9A6
    myosin IXA
    69(a)
    1 ↔ 1
    GL343479.1(402664-480750)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia myo9a1 myosin 9a 63.22(n)
    64.78(a)
      100216086  XM_002934550.2  XP_002934596.2 
    zebrafish
    (Danio rerio)
    Actinopterygii myo9aa1 myosin IXAa 63.96(n)
    67.56(a)
      100006612  XM_001924008.4  XP_001924043.3 
    worm
    (Caenorhabditis elegans)
    Secernentea hum-73 myosin 49(a)   I(585863-607574)   --
    rice
    (Oryza sativa)
    Liliopsida AK102087.12   -- 75.84(n)    AK102087.1 


    ENSEMBL Gene Tree for MYO9A (if available)
    TreeFam Gene Tree for MYO9A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MYO9A gene
    MYO3A2  MYO5C2  MYO102  MYO7A2  MYO162  MYO9B2  MYO5A2  MYO7B2  
    PLEKHH32  MYO5B2  MYO62  MYO3B2  
    Selected SIMAP similar genes for MYO9A using alignment to 9 protein entries:     MYO9A_HUMAN (see all proteins) (see all similar genes):
    MYO1G    MYO1B    MYO1A    MYO1C    ARHGAP24    MYH9
    MYO1D    MYO5C    MYH11    MYO9B    MYH10    ARHGAP12
    MYO10    ARHGAP5    MYO1E    PIK3R1    ARHGAP31    MYH2

    MYO9A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MYO9A (see all 5215)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs611530231,2
    C--49139993(+) TTTTT-/T/TT  
            
    GAAAT
    1 -- int11NA 2
    rs340540951,2
    C--52268430(+) TTTTTT/AAATTT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs30283621,2
    C--52388383(+) TTTTT-/T/TT  
            
    AAATT
    1 -- int1 trp31NA 2
    rs1918360141,2
    C--72117934(+) TAAACA/C/GGTCAC 1 -- ds50010--------
    rs1483621271,2
    C--72117943(+) CATTA-/TTTG  
            
    TTTGT
    1 -- ds50010--------
    rs1392271771,2
    --72118017(+) TTTTCA/GGTTTA 1 -- ds50010--------
    rs1498962451,2
    --72118042(+) AAAAGC/TCTGAA 1 -- ds50010--------
    rs1838645271,2
    --72118068(+) CCTTCA/CTAAGT 1 -- ds50010--------
    rs1900825961,2
    --72118232(+) TATGAC/TATCAA 1 -- ds50010--------
    rs47774621,2
    C,H--72118247(+) CATCAA/TAAAAA 1 -- ds50014Minor allele frequency- T:0.00NS EA 418

    HapMap Linkage Disequilibrium report for MYO9A (72114632 - 72364632 bp, first 250kb of MYO9A)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MYO9A (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821198CNV Deletion20802225
    esv2749858CNV Deletion23290073
    esv2531029CNV Deletion19546169
    esv2331045CNV Deletion18987734
    esv2749862CNV Deletion23290073
    esv2749859CNV Deletion23290073
    esv2672608CNV Deletion23128226
    esv2656527CNV Deletion23128226
    esv2749860CNV Deletion23290073
    esv2749861CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYO9A
    DNA2.0 Custom Variant and Variant Library Synthesis for MYO9A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604875    OMIM disorders: --

    5 diseases for MYO9A:    
    About MalaCards
    bardet-biedl syndrome    spasticity    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    neuronitis


    MYO9A for disorders           About GeneDecksing

    Genetic Association Database (GAD): MYO9A
    Human Genome Epidemiology (HuGE) Navigator: MYO9A (1 document)

    Export disorders for MYO9A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MYO9A gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with MYO9A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cloning and developmental expression of unconventional myosin IXA (MYO9A) a gene in the Bardet-Biedl syndrome (BBS4) region at chromosome 15q22-q23. (PubMed id 10409426)1, 2, 3, 9 Gorman S.W.... Duhl D.M. (Genomics 1999)
    2. Non-EST based prediction of exon skipping and intron retention events using Pfam information. (PubMed id 16204458)1, 2 Hiller M.... Backofen R. (Nucleic Acids Res. 2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. (PubMed id 8022818)1, 2 Bement W.M.... Mooseker M.S. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    5. Vaccinia virus F11 promotes viral spread by acting as a PDZ-containing scaffolding protein to bind myosin-9A and inhibit RhoA signaling. (PubMed id 23870313)1 Handa Y....Way M. (amp 2013)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PubMed id 23319000)1 Luykx J.J....Ophoff R.A. (Mol. Psychiatry 2013)
    8. Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions. (PubMed id 22305756)1 Omelchenko T. and Hall A. (Curr. Biol. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)4 Takefuji M....Kaibuchi K. (J. Hum. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4649 HGNC: 7608 AceView: MYO9A Ensembl:ENSG00000066933 euGenes: HUgn4649
    ECgene: MYO9A H-InvDB: MYO9A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MYO9A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MYO9A gene:
    Search GeneIP for patents involving MYO9A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MYO9A  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MYO9A  
     OriGene qSTAR qPCR primer pairs in human, mouse for MYO9A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MYO9A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MYO9A   OriGene Custom Protein Services for MYO9A  

     
     
     Block miRNA regulation of human, mouse, rat MYO9A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MYO9A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYO9A Predesigned siRNA for gene silencing in human, mouse, rat MYO9A
     QuantiFast Probe-based Assays in human, mouse, rat MYO9A QuantiTect SYBR Green Assays in human, mouse, rat MYO9A
     Custom PCR Arrays for MYO9A Search Chromatin IP Primers for MYO9A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYO9A  Search GeneGlobe Interaction Network for MYO9A
     Regulatory tfbs in MYO9A promoter
     GenScript Custom Purified and Recombinant Proteins Services for MYO9A GenScript cDNA clones with any tag delivered in your preferred vector for MYO9A
     GenScript Custom Assay Services for MYO9A GenScript Custom overexpressing Cell Line Services for MYO9A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MYO9A
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MYO9A antibodies
     MYO9A proteins
     Antibodies for MYO9A
     See all of Abcam's Antibodies, Kits and Proteins for MYO9A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MYO9A
     Antibodies for MYO9A
     ELISAs for MYO9A
     CLIAs for MYO9A



     Browse ESI BIO Cell Lines and PureStem Progenitors for MYO9A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO9A
     SwitchGear 3'UTR luciferase reporter plasmids for MYO9A
     SwitchGear Promoter luciferase reporter plasmids for MYO9A
     Search ThermoFisher Antibodies for MYO9A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO9A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYO9A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYO9A
     LSBio Antibodies in human, mouse, rat for MYO9A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MYO9A gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4