Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MYO9A Gene

Aliases for MYO9A Gene

  • Myosin IXA 2 3 5
  • Unconventional Myosin-9a 3 4
  • Myosin-IXa 3
  • MYR7 4

External Ids for MYO9A Gene

Previous GeneCards Identifiers for MYO9A Gene

  • GC15M067913
  • GC15M065216
  • GC15M069694
  • GC15M069834
  • GC15M069905
  • GC15M072114
  • GC15M048948

Summaries for MYO9A Gene

Entrez Gene Summary for MYO9A Gene

  • This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. [provided by RefSeq, Dec 2011]

GeneCards Summary for MYO9A Gene

MYO9A (Myosin IXA) is a Protein Coding gene. Diseases associated with MYO9A include bardet-biedl syndrome. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYO7B.

UniProtKB/Swiss-Prot for MYO9A Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho activity in neurons, has a role in the regulation of neuronal morphology and function (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO9A Gene

Genomics for MYO9A Gene

Regulatory Elements for MYO9A Gene

Promoters for MYO9A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYO9A on UCSC Golden Path with GeneCards custom track

Genomic Location for MYO9A Gene

Chromosome:
15
Start:
71,822,289 bp from pter
End:
72,118,577 bp from pter
Size:
296,289 bases
Orientation:
Minus strand

Genomic View for MYO9A Gene

Genes around MYO9A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO9A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO9A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO9A Gene

Proteins for MYO9A Gene

  • Protein details for MYO9A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B2RTY4-MYO9A_HUMAN
    Recommended name:
    Unconventional myosin-IXa
    Protein Accession:
    B2RTY4
    Secondary Accessions:
    • B0I1T5
    • C9IYB3
    • C9JA86
    • Q14787
    • Q3YLD7
    • Q3YLD8
    • Q6P986
    • Q9H8T5
    • Q9NTG2
    • Q9NUY2
    • Q9UEP3
    • Q9UNJ2

    Protein attributes for MYO9A Gene

    Size:
    2548 amino acids
    Molecular mass:
    292706 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91979.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14517.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MYO9A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO9A Gene

Proteomics data for MYO9A Gene at MOPED

Post-translational modifications for MYO9A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYO9A Gene

Domains & Families for MYO9A Gene

Gene Families for MYO9A Gene

Suggested Antigen Peptide Sequences for MYO9A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B2RTY4

UniProtKB/Swiss-Prot:

MYO9A_HUMAN :
  • Contains 5 IQ domains.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
Domain:
  • Contains 5 IQ domains.
  • Contains 1 myosin motor domain.
  • Contains 1 Ras-associating domain.
  • Contains 1 Rho-GAP domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with MYO9A: view

Function for MYO9A Gene

Molecular function for MYO9A Gene

GENATLAS Biochemistry:
unconventional myosin IXA,widely expressed,located in the BBS4 region
UniProtKB/Swiss-Prot Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho activity in neurons, has a role in the regulation of neuronal morphology and function (By similarity).

Gene Ontology (GO) - Molecular Function for MYO9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005096 GTPase activator activity IEA,TAS --
genes like me logo Genes that share ontologies with MYO9A: view
genes like me logo Genes that share phenotypes with MYO9A: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYO9A Gene

Localization for MYO9A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO9A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO9A Gene COMPARTMENTS Subcellular localization image for MYO9A gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MYO9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MYO9A: view

Pathways & Interactions for MYO9A Gene

genes like me logo Genes that share pathways with MYO9A: view

Gene Ontology (GO) - Biological Process for MYO9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception TAS 10409426
genes like me logo Genes that share ontologies with MYO9A: view

No data available for SIGNOR curated interactions for MYO9A Gene

Drugs & Compounds for MYO9A Gene

(3) Additional Compounds for MYO9A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with MYO9A: view

Transcripts for MYO9A Gene

Unigene Clusters for MYO9A Gene

Myosin IXA:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYO9A Gene

No ASD Table

Relevant External Links for MYO9A Gene

GeneLoc Exon Structure for
MYO9A
ECgene alternative splicing isoforms for
MYO9A

Expression for MYO9A Gene

mRNA expression in normal human tissues for MYO9A Gene

Protein differential expression in normal tissues from HIPED for MYO9A Gene

This gene is overexpressed in Fetal Liver (49.5) and Testis (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYO9A Gene



SOURCE GeneReport for Unigene cluster for MYO9A Gene Hs.546268

mRNA Expression by UniProt/SwissProt for MYO9A Gene

B2RTY4-MYO9A_HUMAN
Tissue specificity: Found to be expressed in testis and placenta, and at lower levels in all the examined tissues with the exception of liver. Isoform 5 was found in leukocytes but not in brain, retina or testis.
genes like me logo Genes that share expression patterns with MYO9A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for MYO9A Gene

Orthologs for MYO9A Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO9A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO9A 36
  • 97 (a)
OneToOne
MYO9A 35
  • 99.56 (n)
  • 99.45 (a)
cow
(Bos Taurus)
Mammalia MYO9A 36
  • 79 (a)
OneToOne
LOC515330 35
  • 90.33 (n)
  • 88.81 (a)
dog
(Canis familiaris)
Mammalia MYO9A 35
  • 91.88 (n)
  • 92.3 (a)
MYO9A 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo9a 36
  • 86 (a)
OneToOne
Myo9a 16
Myo9a 35
  • 87.31 (n)
  • 87.88 (a)
oppossum
(Monodelphis domestica)
Mammalia MYO9A 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYO9A 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myo9a 35
  • 87.06 (n)
  • 87.7 (a)
chicken
(Gallus gallus)
Aves MYO9A 35
  • 71.17 (n)
  • 75.57 (a)
MYO9A 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYO9A 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo9a 35
  • 63.22 (n)
  • 64.78 (a)
zebrafish
(Danio rerio)
Actinopterygii myo9aa 36
  • 64 (a)
OneToMany
myo9ab 36
  • 59 (a)
OneToMany
myo9aa 35
  • 63.96 (n)
  • 67.56 (a)
worm
(Caenorhabditis elegans)
Secernentea hum-7 37
  • 49 (a)
hum-7 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for MYO9A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYO9A Gene

ENSEMBL:
Gene Tree for MYO9A (if available)
TreeFam:
Gene Tree for MYO9A (if available)

Paralogs for MYO9A Gene

Paralogs for MYO9A Gene

genes like me logo Genes that share paralogs with MYO9A: view

Variants for MYO9A Gene

Sequence variations from dbSNP and Humsavar for MYO9A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs8747 -- 71,823,200(-) AAGAA(G/T)AAAGG utr-variant-3-prime
rs748471 -- 71,973,833(+) GAGAA(A/G)CGCTA intron-variant
rs748472 -- 71,974,823(-) AGTCT(A/G)GCAAG intron-variant
rs748473 -- 71,974,657(-) CCTTA(A/G)GAATT intron-variant
rs972028 -- 71,880,751(-) AAATA(C/T)GCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO9A Gene

Variant ID Type Subtype PubMed ID
nsv904334 CNV Gain 21882294
esv2531029 CNV Deletion 19546169
nsv516871 CNV Gain+Loss 19592680
nsv904336 CNV Loss 21882294
nsv457195 CNV Loss 19166990
esv2749858 CNV Deletion 23290073
esv2749859 CNV Deletion 23290073
esv2331045 CNV Deletion 18987734
esv2749860 CNV Deletion 23290073
esv2749861 CNV Deletion 23290073
nsv510405 CNV Loss 20534489
esv2672608 CNV Deletion 23128226
nsv457199 CNV Loss 19166990
nsv457200 CNV Loss 19166990
nsv457201 CNV Loss 19166990
esv2656527 CNV Deletion 23128226
nsv833051 CNV Gain 17160897
esv28860 CNV Gain 19812545
nsv904337 CNV Loss 21882294
nsv510665 CNV Loss 20534489
nsv512406 CNV Loss 21212237
nsv821198 CNV Deletion 20802225
esv2749862 CNV Deletion 23290073
nsv511557 CNV Loss 21212237

Variation tolerance for MYO9A Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.54; 77.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO9A Gene

HapMap Linkage Disequilibrium report
MYO9A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO9A Gene

Disorders for MYO9A Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYO9A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bardet-biedl syndrome
  • biedl-bardet syndrome
- elite association - COSMIC cancer census association via MalaCards
Search MYO9A in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYO9A

Genetic Association Database (GAD)
MYO9A
Human Genome Epidemiology (HuGE) Navigator
MYO9A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO9A
genes like me logo Genes that share disorders with MYO9A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYO9A Gene

Publications for MYO9A Gene

  1. The cloning and developmental expression of unconventional myosin IXA (MYO9A) a gene in the Bardet-Biedl syndrome (BBS4) region at chromosome 15q22-q23. (PMID: 10409426) Gorman S.W. … Duhl D.M. (Genomics 1999) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Proximity Interactions among Centrosome Components Identify Regulators of Centriole Duplication. (PMID: 24613305) Firat-Karalar E.N. … Stearns T. (Curr. Biol. 2014) 3
  4. Vaccinia virus F11 promotes viral spread by acting as a PDZ-containing scaffolding protein to bind myosin-9A and inhibit RhoA signaling. (PMID: 23870313) Handa Y. … Way M. (Cell Host Microbe 2013) 3
  5. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PMID: 23319000) Luykx J.J. … Ophoff R.A. (Mol. Psychiatry 2013) 3

Products for MYO9A Gene

Sources for MYO9A Gene

Back to Top

Content