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Aliases for MYO7B Gene

Aliases for MYO7B Gene

  • Myosin VIIB 2 3 5
  • Unconventional Myosin-VIIb 3
  • Myosin-VIIb 3

External Ids for MYO7B Gene

Previous GeneCards Identifiers for MYO7B Gene

  • GC02U990069
  • GC02P128282
  • GC02P128470
  • GC02P128093
  • GC02P128009
  • GC02P120600
  • GC02P128293

Summaries for MYO7B Gene

GeneCards Summary for MYO7B Gene

MYO7B (Myosin VIIB) is a Protein Coding gene. GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYO7A.

UniProtKB/Swiss-Prot for MYO7B Gene

  • Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli (Probable).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO7B Gene

Genomics for MYO7B Gene

Regulatory Elements for MYO7B Gene

Enhancers for MYO7B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F127629 1.2 Ensembl ENCODE 19.3 +101.5 101508 15.2 HDGF ARID4B DMAP1 ZNF48 GLIS2 ZNF207 REST KAT8 MAFF SMARCA4 GPR17 MYO7B ENSG00000272789 LIMS2 ENSG00000236682 MAP3K2 ERCC3 BIN1 LOC101927834
GH02F127591 1.1 Ensembl ENCODE 18 +55.8 55808 0.6 ELF3 ARID4B ZNF48 ZNF2 RAD21 GLIS2 ZNF143 CREM THAP11 ZNF654 MYO7B GPR17 LIMS2 ERCC3 LOC105373609 ENSG00000272789
GH02F127507 1.6 FANTOM5 Ensembl ENCODE 11.7 -26.0 -25986 4.9 PKNOX1 SIN3A FEZF1 ZNF2 FOS ZNF263 TSHZ1 ZNF264 MAFF PBX2 AMMECR1L SFT2D3 ENSG00000236682 WDR33 UGGT1 MYO7B RNU4-48P LIMS2 ERCC3 IWS1
GH02F127562 1.3 Ensembl ENCODE 11.4 +28.0 27974 1.7 PKNOX1 ATF1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 GLIS2 ZNF143 ZNF207 GPR17 ERCC3 MYO7B LIMS2 WDR33 LOC105373609
GH02F127574 0.9 Ensembl ENCODE 12 +40.4 40408 2.6 BCOR CTCF ZNF133 ZMYM3 TBX21 ATF2 MEF2D ATF3 ADNP TRIM24 GPR17 MYO7B LIMS2 ENSG00000236682 ERCC3 MAP3K2 LOC105373609 ENSG00000272789
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYO7B on UCSC Golden Path with GeneCards custom track

Genomic Location for MYO7B Gene

Chromosome:
2
Start:
127,535,693 bp from pter
End:
127,637,729 bp from pter
Size:
102,037 bases
Orientation:
Plus strand

Genomic View for MYO7B Gene

Genes around MYO7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO7B Gene

Proteins for MYO7B Gene

  • Protein details for MYO7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PIF6-MYO7B_HUMAN
    Recommended name:
    Unconventional myosin-VIIb
    Protein Accession:
    Q6PIF6
    Secondary Accessions:
    • Q14786
    • Q8TEE1

    Protein attributes for MYO7B Gene

    Size:
    2116 amino acids
    Molecular mass:
    241599 Da
    Quaternary structure:
    • Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5 (PubMed:24725409, PubMed:26812018). Interacts with CDHR2 (PubMed:24725409). Interacts with CDHR5 (PubMed:24725409). Interacts with USH1C (PubMed:24725409, PubMed:26812017, PubMed:26812018). Interacts with ANKS4B; requires initial interaction with USH1C (PubMed:26812018).
    SequenceCaution:
    • Sequence=AAH35615.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MYO7B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO7B Gene

Post-translational modifications for MYO7B Gene

  • Ubiquitination at Lys 1149, Lys 1287, Lys 1323, Lys 1346, Lys 1359, Lys 1364, Lys 1379, Lys 1385, Lys 1513, Lys 1525, Lys 1534, Lys 1553, Lys 1570, Lys 1585, Lys 1624, Lys 1655, Lys 1781, Lys 1802, Lys 1854, Lys 1877, Lys 1893, Lys 1940, Lys 1999, Lys 2104, and Lys 2109
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MYO7B Gene

Domains & Families for MYO7B Gene

Gene Families for MYO7B Gene

Suggested Antigen Peptide Sequences for MYO7B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PIF6

UniProtKB/Swiss-Prot:

MYO7B_HUMAN :
  • Contains 2 FERM domains.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • Contains 2 FERM domains.
  • Contains 6 IQ domains.
  • Contains 1 myosin motor domain.
  • Contains 3 MyTH4 domains.
  • Contains 2 SH3 domains.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO7B: view

Function for MYO7B Gene

Molecular function for MYO7B Gene

UniProtKB/Swiss-Prot Function:
Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli (Probable).

Gene Ontology (GO) - Molecular Function for MYO7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 24725409
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYO7B: view
genes like me logo Genes that share phenotypes with MYO7B: view

Animal Models for MYO7B Gene

MGI Knock Outs for MYO7B:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MYO7B Gene

Localization for MYO7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO7B Gene

Cytoplasm, cytoskeleton. Cell projection, microvillus. Note=Enriched in the microvilli of the intestinal brush border. {ECO:0000269 PubMed:24725409}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYO7B gene
Compartment Confidence
extracellular 5
cytoskeleton 4
cytosol 3

Gene Ontology (GO) - Cellular Components for MYO7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005902 microvillus IEA,IDA 24725409
GO:0005903 brush border IDA 24725409
GO:0016459 myosin complex IEA --
genes like me logo Genes that share ontologies with MYO7B: view

Pathways & Interactions for MYO7B Gene

SuperPathways for MYO7B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYO7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
GO:1904970 brush border assembly IPI 24725409
genes like me logo Genes that share ontologies with MYO7B: view

No data available for Pathways by source and SIGNOR curated interactions for MYO7B Gene

Transcripts for MYO7B Gene

Unigene Clusters for MYO7B Gene

Myosin VIIB:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO7B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns: 20 ^ 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for MYO7B Gene

GeneLoc Exon Structure for
MYO7B
ECgene alternative splicing isoforms for
MYO7B

Expression for MYO7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYO7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYO7B Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x13.5), Colon - Transverse (x13.5), and Spleen (x5.6).

Protein differential expression in normal tissues from HIPED for MYO7B Gene

This gene is overexpressed in Fetal gut (20.0), Cerebrospinal fluid (18.7), and Plasma (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYO7B Gene



NURSA nuclear receptor signaling pathways regulating expression of MYO7B Gene:

MYO7B

SOURCE GeneReport for Unigene cluster for MYO7B Gene:

Hs.154578
genes like me logo Genes that share expression patterns with MYO7B: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MYO7B Gene

Orthologs for MYO7B Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO7B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO7B 34 35
  • 97.31 (n)
dog
(Canis familiaris)
Mammalia MYO7B 34 35
  • 87.23 (n)
cow
(Bos Taurus)
Mammalia MYO7B 35 34
  • 86.46 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myo7b 34
  • 83.07 (n)
mouse
(Mus musculus)
Mammalia Myo7b 34 16 35
  • 82.91 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 74 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
chicken
(Gallus gallus)
Aves MYO7B 35 34
  • 66.84 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYO7B 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo7b 34
  • 60.68 (n)
zebrafish
(Danio rerio)
Actinopterygii MYO7B (1 of 2) 35
  • 51 (a)
OneToMany
myo7bb 35
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ck 35
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hum-6 34 35
  • 50.81 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
Species where no ortholog for MYO7B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYO7B Gene

ENSEMBL:
Gene Tree for MYO7B (if available)
TreeFam:
Gene Tree for MYO7B (if available)

Paralogs for MYO7B Gene

Paralogs for MYO7B Gene

genes like me logo Genes that share paralogs with MYO7B: view

Variants for MYO7B Gene

Sequence variations from dbSNP and Humsavar for MYO7B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10164978 -- 127,627,649(+) GGTGG(C/G)CTGGA intron-variant
rs10174611 -- 127,623,579(+) CATAT(A/G)GTCAC intron-variant
rs10175248 -- 127,618,270(+) tgaac(A/G)tagaa intron-variant
rs10175435 -- 127,618,420(+) aggag(A/G)taacg intron-variant
rs10177052 -- 127,571,261(+) aggac(A/C)tggtc intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MYO7B Gene

Variant ID Type Subtype PubMed ID
nsv953155 CNV deletion 24416366
nsv953154 CNV deletion 24416366
nsv583037 CNV loss 21841781
nsv518085 CNV loss 19592680
nsv517532 CNV loss 19592680
nsv508864 CNV insertion 20534489
nsv470482 CNV loss 18288195
nsv2912 CNV deletion 18451855
nsv1012655 CNV gain 25217958
esv3893304 CNV loss 25118596
esv3592365 CNV gain 21293372
esv2720730 CNV deletion 23290073
dgv4069n100 CNV gain 25217958
dgv4068n100 CNV gain 25217958
dgv4067n100 CNV gain 25217958
dgv2027n106 CNV deletion 24896259

Variation tolerance for MYO7B Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.52; 96.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO7B Gene

Human Gene Mutation Database (HGMD)
MYO7B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYO7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO7B Gene

Disorders for MYO7B Gene

Relevant External Links for MYO7B

Genetic Association Database (GAD)
MYO7B
Human Genome Epidemiology (HuGE) Navigator
MYO7B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO7B

No disorders were found for MYO7B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYO7B Gene

Publications for MYO7B Gene

  1. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. (PMID: 8022818) Bement W.M. … Mooseker M.S. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 64
  2. ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation. (PMID: 26812018) Crawley S.W. … Tyska M.J. (Dev. Cell 2016) 3 4 64
  3. Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion. (PMID: 24725409) Crawley S.W. … Tyska M.J. (Cell 2014) 3 4 64
  4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64
  5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64

Products for MYO7B Gene

Sources for MYO7B Gene

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