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Aliases for MYO7B Gene

Aliases for MYO7B Gene

  • Myosin VIIB 2 3 5
  • Unconventional Myosin-VIIb 3
  • Myosin-VIIb 3

External Ids for MYO7B Gene

Previous GeneCards Identifiers for MYO7B Gene

  • GC02U990069
  • GC02P128282
  • GC02P128470
  • GC02P128093
  • GC02P128009
  • GC02P120600
  • GC02P128293

Summaries for MYO7B Gene

Entrez Gene Summary for MYO7B Gene

  • The protein encoded by this gene is found in brush border microvilli of epithelial cells in the intestines and kidneys. The encoded protein is involved in linking protocadherins to the actin cytoskeleton and is essential for proper microvilli function. This protein aids in the accumulation of intermicrovillar adhesion components such as harmonin and ANKS4B, and this accumulation is necessary for normal brush border action. [provided by RefSeq, Jan 2017]

GeneCards Summary for MYO7B Gene

MYO7B (Myosin VIIB) is a Protein Coding gene. GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYO7A.

UniProtKB/Swiss-Prot for MYO7B Gene

  • Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli (Probable).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO7B Gene

Genomics for MYO7B Gene

Regulatory Elements for MYO7B Gene

Enhancers for MYO7B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G127635 1.4 Ensembl ENCODE dbSUPER 19.3 +103.4 103402 7.8 FOXA2 ARID4B DMAP1 ZNF48 GLIS2 ZNF207 ZNF143 FOS KAT8 MAFF GPR17 MYO7B ENSG00000272789 LIMS2 ENSG00000236682 MAP3K2 ERCC3 LOC101927834
GH02G127507 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -26.0 -25986 4.9 PKNOX1 SIN3A FEZF1 ZNF2 GATA2 FOS ZNF263 TSHZ1 MAFF SMARCA4 SFT2D3 ENSG00000236682 MYO7B RNU4-48P LIMS2 ERCC3 IWS1 ENSG00000231731 AMMECR1L MAP3K2
GH02G127621 0.9 dbSUPER 19.1 +89.3 89293 7.2 FOXA2 MLX ARID4B ZNF48 ZNF121 FOS SP5 MXD4 ZHX2 MIER2 GPR17 MYO7B LIMS2 ENSG00000236682 BIN1 ENSG00000272789 LOC105373609
GH02G127591 1.4 Ensembl ENCODE dbSUPER 11.7 +55.9 55908 0.4 ELF3 RB1 ARID4B ZNF2 ZNF48 RAD21 GLIS2 ZNF143 CREM THAP11 GPR17 LIMS2 MYO7B LOC105373609 ENSG00000272789
GH02G127562 1.3 Ensembl ENCODE 11.4 +28.0 27974 1.7 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF143 ZNF207 KLF13 ZNF263 SP3 GPR17 MYO7B LIMS2 LOC105373609
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYO7B on UCSC Golden Path with GeneCards custom track

Genomic Location for MYO7B Gene

Chromosome:
2
Start:
127,535,693 bp from pter
End:
127,637,729 bp from pter
Size:
102,037 bases
Orientation:
Plus strand

Genomic View for MYO7B Gene

Genes around MYO7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO7B Gene

Proteins for MYO7B Gene

  • Protein details for MYO7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PIF6-MYO7B_HUMAN
    Recommended name:
    Unconventional myosin-VIIb
    Protein Accession:
    Q6PIF6
    Secondary Accessions:
    • Q14786
    • Q8TEE1

    Protein attributes for MYO7B Gene

    Size:
    2116 amino acids
    Molecular mass:
    241599 Da
    Quaternary structure:
    • Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5 (PubMed:24725409, PubMed:26812018). Interacts with CDHR2 (PubMed:24725409). Interacts with CDHR5 (PubMed:24725409). Interacts with USH1C (PubMed:24725409, PubMed:26812017, PubMed:26812018). Interacts with ANKS4B; requires initial interaction with USH1C (PubMed:26812018).
    SequenceCaution:
    • Sequence=AAH35615.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MYO7B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO7B Gene

Post-translational modifications for MYO7B Gene

  • Ubiquitination at posLast=11491149, Lys1287, Lys1323, posLast=13461346, posLast=13591359, Lys1364, Lys1379, Lys1385, posLast=15131513, posLast=15251525, Lys1534, posLast=15531553, posLast=15701570, posLast=15851585, Lys1624, Lys1655, posLast=17811781, posLast=18021802, Lys1854, Lys1877, Lys1893, posLast=19401940, posLast=19991999, Lys2104, and posLast=21092109
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MYO7B Gene

Domains & Families for MYO7B Gene

Gene Families for MYO7B Gene

Suggested Antigen Peptide Sequences for MYO7B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PIF6

UniProtKB/Swiss-Prot:

MYO7B_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO7B: view

Function for MYO7B Gene

Molecular function for MYO7B Gene

UniProtKB/Swiss-Prot Function:
Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli (Probable).

Gene Ontology (GO) - Molecular Function for MYO7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 24725409
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYO7B: view
genes like me logo Genes that share phenotypes with MYO7B: view

Animal Models for MYO7B Gene

MGI Knock Outs for MYO7B:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MYO7B Gene

Localization for MYO7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO7B Gene

Cytoplasm, cytoskeleton. Cell projection, microvillus. Note=Enriched in the microvilli of the intestinal brush border. {ECO:0000269 PubMed:24725409}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYO7B gene
Compartment Confidence
extracellular 5
cytoskeleton 4
cytosol 3

Gene Ontology (GO) - Cellular Components for MYO7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005902 microvillus IEA,IDA 24725409
GO:0005903 brush border IDA 24725409
GO:0016459 myosin complex IEA --
genes like me logo Genes that share ontologies with MYO7B: view

Pathways & Interactions for MYO7B Gene

SuperPathways for MYO7B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYO7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
GO:1904970 brush border assembly IPI 24725409
genes like me logo Genes that share ontologies with MYO7B: view

No data available for Pathways by source and SIGNOR curated interactions for MYO7B Gene

Drugs & Compounds for MYO7B Gene

No Compound Related Data Available

Transcripts for MYO7B Gene

mRNA/cDNA for MYO7B Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYO7B Gene

Myosin VIIB:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO7B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns: 20 ^ 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for MYO7B Gene

GeneLoc Exon Structure for
MYO7B
ECgene alternative splicing isoforms for
MYO7B

Expression for MYO7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYO7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYO7B Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x13.5), Colon - Transverse (x13.5), and Spleen (x5.6).

Protein differential expression in normal tissues from HIPED for MYO7B Gene

This gene is overexpressed in Fetal gut (20.0), Cerebrospinal fluid (18.7), and Plasma (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYO7B Gene



NURSA nuclear receptor signaling pathways regulating expression of MYO7B Gene:

MYO7B

SOURCE GeneReport for Unigene cluster for MYO7B Gene:

Hs.154578

Evidence on tissue expression from TISSUES for MYO7B Gene

  • Spleen(4.2)
genes like me logo Genes that share expression patterns with MYO7B: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYO7B Gene

Orthologs for MYO7B Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO7B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO7B 34 35
  • 97.31 (n)
dog
(Canis familiaris)
Mammalia MYO7B 34 35
  • 87.23 (n)
cow
(Bos Taurus)
Mammalia MYO7B 34 35
  • 86.46 (n)
rat
(Rattus norvegicus)
Mammalia Myo7b 34
  • 83.07 (n)
mouse
(Mus musculus)
Mammalia Myo7b 34 16 35
  • 82.91 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 74 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
chicken
(Gallus gallus)
Aves MYO7B 34 35
  • 66.84 (n)
lizard
(Anolis carolinensis)
Reptilia MYO7B 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo7b 34
  • 60.68 (n)
zebrafish
(Danio rerio)
Actinopterygii MYO7B (1 of 2) 35
  • 51 (a)
OneToMany
myo7bb 35
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ck 35
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hum-6 34 35
  • 50.81 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
Species where no ortholog for MYO7B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYO7B Gene

ENSEMBL:
Gene Tree for MYO7B (if available)
TreeFam:
Gene Tree for MYO7B (if available)

Paralogs for MYO7B Gene

Paralogs for MYO7B Gene

genes like me logo Genes that share paralogs with MYO7B: view

Variants for MYO7B Gene

Sequence variations from dbSNP and Humsavar for MYO7B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs371259809 Uncertain significance 127,580,788(+) GGAGA(C/T)GCCCG nc-transcript-variant, reference, missense
rs1000050044 -- 127,633,697(+) TCCCA(C/G)TGTGT intron-variant
rs1000095118 -- 127,580,897(+) ACACC(G/T)GATTC intron-variant
rs1000102926 -- 127,609,544(+) GTTGA(A/C)CTGGA nc-transcript-variant, reference, missense
rs1000140348 -- 127,589,172(+) ATGGA(C/T)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO7B Gene

Variant ID Type Subtype PubMed ID
dgv2027n106 CNV deletion 24896259
dgv4067n100 CNV gain 25217958
dgv4068n100 CNV gain 25217958
dgv4069n100 CNV gain 25217958
esv2720730 CNV deletion 23290073
esv3592365 CNV gain 21293372
esv3893304 CNV loss 25118596
nsv1012655 CNV gain 25217958
nsv2912 CNV deletion 18451855
nsv470482 CNV loss 18288195
nsv508864 CNV insertion 20534489
nsv517532 CNV loss 19592680
nsv518085 CNV loss 19592680
nsv583037 CNV loss 21841781
nsv953154 CNV deletion 24416366
nsv953155 CNV deletion 24416366

Variation tolerance for MYO7B Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.52; 96.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO7B Gene

Human Gene Mutation Database (HGMD)
MYO7B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYO7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO7B Gene

Disorders for MYO7B Gene

Relevant External Links for MYO7B

Genetic Association Database (GAD)
MYO7B
Human Genome Epidemiology (HuGE) Navigator
MYO7B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO7B

No disorders were found for MYO7B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYO7B Gene

Publications for MYO7B Gene

  1. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. (PMID: 8022818) Bement W.M. … Mooseker M.S. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 64
  2. Mechanistic basis of organization of the Harmonin/USH1C-mediated brush border microvilli tip-link complex. (PMID: 26812017) Li J. … Zhang M. (Dev. Cell 2016) 3 4 64
  3. ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation. (PMID: 26812018) Crawley S.W. … Tyska M.J. (Dev. Cell 2016) 3 4 64
  4. Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion. (PMID: 24725409) Crawley S.W. … Tyska M.J. (Cell 2014) 3 4 64
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64

Products for MYO7B Gene

Sources for MYO7B Gene

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