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Aliases for MYO7B Gene

Aliases for MYO7B Gene

  • Myosin VIIB 2 3
  • Unconventional Myosin-VIIb 3
  • Myosin-VIIb 3

External Ids for MYO7B Gene

Summaries for MYO7B Gene

GeneCards Summary for MYO7B Gene

MYO7B (Myosin VIIB) is a Protein Coding gene. GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYO7A.

UniProtKB/Swiss-Prot for MYO7B Gene

  • Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be have a role in the apical membranes of transporting epithelia (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO7B Gene

Genomics for MYO7B Gene

Genomic Location for MYO7B Gene

Start:
127,535,763 bp from pter
End:
127,637,729 bp from pter
Size:
101,967 bases
Orientation:
Plus strand

Genomic View for MYO7B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYO7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO7B Gene

Regulatory Elements for MYO7B Gene

Proteins for MYO7B Gene

  • Protein details for MYO7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PIF6-MYO7B_HUMAN
    Recommended name:
    Unconventional myosin-VIIb
    Protein Accession:
    Q6PIF6
    Secondary Accessions:
    • Q14786
    • Q8TEE1

    Protein attributes for MYO7B Gene

    Size:
    2116 amino acids
    Molecular mass:
    241599 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH35615.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MYO7B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO7B Gene

Proteomics data for MYO7B Gene at MOPED

Post-translational modifications for MYO7B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys1149, Lys1287, Lys1323, Lys1346, Lys1359, Lys1364, Lys1379, Lys1385, Lys1513, Lys1525, Lys1533, Lys1534, Lys1553, Lys1570, Lys1585, Lys1624, Lys1655, Lys1781, Lys1802, Lys1854, Lys1877, Lys1893, Lys1940, Lys1999, Lys2104, and Lys2109

Other Protein References for MYO7B Gene

No data available for DME Specific Peptides for MYO7B Gene

Domains for MYO7B Gene

Gene Families for MYO7B Gene

HGNC:
  • MYOVII :Myosins / Myosin superfamily : Class VII

Suggested Antigen Peptide Sequences for MYO7B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PIF6

UniProtKB/Swiss-Prot:

MYO7B_HUMAN
Domain:
  • Contains 2 FERM domains.:
    • Q6PIF6
  • Contains 6 IQ domains.:
    • Q6PIF6
  • Contains 1 myosin motor domain.:
    • Q6PIF6
  • Contains 3 MyTH4 domains.:
    • Q6PIF6
  • Contains 2 SH3 domains.:
    • Q6PIF6
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.:
    • Q6PIF6
genes like me logo Genes that share domains with MYO7B: view

Function for MYO7B Gene

Molecular function for MYO7B Gene

UniProtKB/Swiss-Prot Function: Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be have a role in the apical membranes of transporting epithelia (By similarity).

Gene Ontology (GO) - Molecular Function for MYO7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 24725409
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYO7B: view

Phenotypes for MYO7B Gene

GenomeRNAi human phenotypes for MYO7B:
genes like me logo Genes that share phenotypes with MYO7B: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MYO7B Gene

Localization for MYO7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO7B Gene

Apical cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO7B Gene COMPARTMENTS Subcellular localization image for MYO7B gene
Compartment Confidence
cytoskeleton 3
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MYO7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton --
GO:0005886 plasma membrane --
GO:0016324 apical plasma membrane IEA --
GO:0016459 myosin complex IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MYO7B: view

Pathways for MYO7B Gene

SuperPathways for MYO7B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYO7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with MYO7B: view

No data available for Pathways by source for MYO7B Gene

Transcripts for MYO7B Gene

Unigene Clusters for MYO7B Gene

Myosin VIIB:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYO7B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns: 20 ^ 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for MYO7B Gene

GeneLoc Exon Structure for
MYO7B
ECgene alternative splicing isoforms for
MYO7B

Expression for MYO7B Gene

mRNA expression in normal human tissues for MYO7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYO7B Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (13.5), Colon - Transverse (13.5), and Spleen (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYO7B Gene

SOURCE GeneReport for Unigene cluster for MYO7B Gene Hs.154578

genes like me logo Genes that share expressions with MYO7B: view

No data available for mRNA Expression by UniProt/SwissProt for MYO7B Gene

Orthologs for MYO7B Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO7B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO7B 35
  • 97.31 (n)
  • 96.58 (a)
MYO7B 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYO7B 35
  • 86.46 (n)
  • 84.53 (a)
MYO7B 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO7B 35
  • 87.23 (n)
  • 86.41 (a)
MYO7B 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo7b 35
  • 82.91 (n)
  • 81.91 (a)
Myo7b 16
Myo7b 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Myo7b 35
  • 83.07 (n)
  • 81.79 (a)
chicken
(Gallus gallus)
Aves MYO7B 35
  • 66.84 (n)
  • 63.47 (a)
MYO7B 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYO7B 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo7b 35
  • 60.68 (n)
  • 56.43 (a)
zebrafish
(Danio rerio)
Actinopterygii MYO7B (1 of 2) 36
  • 51 (a)
OneToMany
myo7bb 36
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ck 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hum-6 35
  • 50.81 (n)
  • 47.47 (a)
hum-6 36
  • 45 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for MYO7B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYO7B Gene

ENSEMBL:
Gene Tree for MYO7B (if available)
TreeFam:
Gene Tree for MYO7B (if available)

Paralogs for MYO7B Gene

Paralogs for MYO7B Gene

genes like me logo Genes that share paralogs with MYO7B: view

Variants for MYO7B Gene

Sequence variations from dbSNP and Humsavar for MYO7B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs705092 -- 127,612,625(+) ATCCC(A/G)GCCCC intron-variant
rs777432 -- 127,609,517(+) GAATC(A/G)AAGAC synonymous-codon, reference
rs777433 -- 127,610,660(+) TTACA(C/T)GCAGT intron-variant
rs777434 -- 127,610,750(+) TACCT(C/G)TGGGG intron-variant
rs777435 -- 127,612,321(+) ATCAC(A/G)GGCCA intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MYO7B Gene

Variant ID Type Subtype PubMed ID
nsv875014 CNV Loss 21882294
nsv2912 CNV Loss 18451855
nsv875015 CNV Loss 21882294
dgv4298n71 CNV Loss 21882294
dgv4299n71 CNV Loss 21882294
nsv518085 CNV Loss 19592680
nsv508864 CNV Insertion 20534489
nsv470482 CNV Loss 18288195
esv2720730 CNV Deletion 23290073
dgv4300n71 CNV Loss 21882294
nsv875026 CNV Loss 21882294
nsv517532 CNV Loss 19592680
nsv875027 CNV Loss 21882294
nsv875028 CNV Gain 21882294

Relevant External Links for MYO7B Gene

HapMap Linkage Disequilibrium report
MYO7B
Human Gene Mutation Database (HGMD)
MYO7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO7B Gene

Disorders for MYO7B Gene

Relevant External Links for MYO7B

Genetic Association Database (GAD)
MYO7B
Human Genome Epidemiology (HuGE) Navigator
MYO7B
genes like me logo Genes that share disorders with MYO7B: view

No data available for UniProtKB/Swiss-Prot for MYO7B Gene

Publications for MYO7B Gene

  1. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. (PMID: 8022818) Bement W.M. … Mooseker M.S. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4
  2. Mapping of unconventional myosins in mouse and human. (PMID: 8884266) Hasson T. … Jenkins N.A. (Genomics 1996) 2 3
  3. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PMID: 19724895) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2009) 3 48
  4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 48
  5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 48

Products for MYO7B Gene

Sources for MYO7B Gene

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