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Aliases for MYO7A Gene

Aliases for MYO7A Gene

  • Myosin VIIA 2 3 5
  • Myosin VIIA (Usher Syndrome 1B (Autosomal Recessive, Severe)) 2 3
  • USH1B 3 4
  • Unconventional Myosin-VIIa 3
  • MYOVIIA 3
  • DFNA11 3
  • MYU7A 3
  • NSRD2 3
  • DFNB2 3

External Ids for MYO7A Gene

Previous HGNC Symbols for MYO7A Gene

  • USH1B
  • DFNB2
  • DFNA11

Previous GeneCards Identifiers for MYO7A Gene

  • GC11P079166
  • GC11P078378
  • GC11P077062
  • GC11P076565
  • GC11P076516
  • GC11P076839
  • GC11P073136

Summaries for MYO7A Gene

Entrez Gene Summary for MYO7A Gene

  • This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYO7A Gene

MYO7A (Myosin VIIA) is a Protein Coding gene. Diseases associated with MYO7A include Usher Syndrome, Type 1B and Deafness, Autosomal Dominant 11. Among its related pathways are Metabolism of fat-soluble vitamins and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include protein homodimerization activity and protein domain specific binding. An important paralog of this gene is MYO7B.

UniProtKB/Swiss-Prot for MYO7A Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.

Gene Wiki entry for MYO7A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO7A Gene

Genomics for MYO7A Gene

Regulatory Elements for MYO7A Gene

Enhancers for MYO7A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F077186 0.5 FANTOM5 ENCODE 18.8 +59.9 59909 3.2 CTCF ESRRA ARID4B MAX CEBPG ZNF48 RAD21 GATAD1 SCRT2 ZNF143 MYO7A FTH1P16 PIR53181
GH11F077191 1.3 Ensembl ENCODE 17.3 +63.9 63860 1.3 PKNOX1 ATF1 CREB3L1 SIN3A YBX1 ZNF2 GLIS2 ZNF263 SP3 YY2 MYO7A GDPD4 ENSG00000261578 PAK1 PIR53181
GH11F077039 0.8 Ensembl ENCODE 10.9 -88.2 -88184 1.4 CTCF RNF2 NR2F1 MAX RAD21 SMC3 ZBTB33 KDM1A NR2F6 KDM6A OMP MYO7A ACER3 B3GNT6 LOC105369399
GH11F077038 0.6 ENCODE 10.9 -89.5 -89470 1.0 ESRRA JUN ZNF664 GATA3 NR2F6 NFE2 FOS SMARCE1 MTA2 RNF2 OMP MYO7A ACER3 B3GNT6 LOC105369399
GH11F077019 0.7 ENCODE 10.9 -107.7 -107741 1.7 ELF3 PKNOX1 GATA2 FOS EGR2 USF2 ZNF217 MBD2 RAD51 MTA1 MYO7A LOC105369396 GDPD4 B3GNT6 ACER3 ENSG00000254988
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MYO7A on UCSC Golden Path with GeneCards custom track

Promoters for MYO7A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000565781 -914 601 ELF3 HDAC1 ATF1 SIN3A ARID4B ZSCAN9 ZNF2 RAD21 GATA2 ZNF143

Genomic Location for MYO7A Gene

Chromosome:
11
Start:
77,128,214 bp from pter
End:
77,215,241 bp from pter
Size:
87,028 bases
Orientation:
Plus strand

Genomic View for MYO7A Gene

Genes around MYO7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO7A Gene

Proteins for MYO7A Gene

  • Protein details for MYO7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13402-MYO7A_HUMAN
    Recommended name:
    Unconventional myosin-VIIa
    Protein Accession:
    Q13402
    Secondary Accessions:
    • B9A011
    • F8VUN5
    • P78427
    • Q13321
    • Q14785
    • Q92821
    • Q92822

    Protein attributes for MYO7A Gene

    Size:
    2215 amino acids
    Molecular mass:
    254390 Da
    Quaternary structure:
    • Might homodimerize in a two headed molecule through the formation of a coiled-coil rod (By similarity). Interacts with MYRIP (PubMed:11964381). Interacts with RPE65 (PubMed:21493626). Identified in a complex with USH1C and USH1G (PubMed:21709241). Interacts with CIB2 (PubMed:23023331). May interact with CALM (PubMed:15300860). Interacts with WHRN. Interacts with PLEKHB1 (via PH domain). Interacts with PCDH15. Interacts with TWF2. Interacts with USH1G (By similarity).

    Alternative splice isoforms for MYO7A Gene

neXtProt entry for MYO7A Gene

Post-translational modifications for MYO7A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for MYO7A Gene

Domains & Families for MYO7A Gene

Suggested Antigen Peptide Sequences for MYO7A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13402

UniProtKB/Swiss-Prot:

MYO7A_HUMAN :
  • The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds.
  • Contains 2 FERM domains.
  • Contains 5 IQ domains.
  • Contains 1 myosin motor domain.
  • Contains 2 MyTH4 domains.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO7A: view

Function for MYO7A Gene

Molecular function for MYO7A Gene

GENATLAS Biochemistry:
myosin VIIA,145kDa,unconventional,apparently non filamentous,mainly expressed in hair cells of cochlea and pigment epithelium of the retina and testis
UniProtKB/Swiss-Prot EnzymeRegulation:
ATP hydrolysis is inhibited by Mg(2+), already at a concentration of 0.4 mM.
UniProtKB/Swiss-Prot Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.

Gene Ontology (GO) - Molecular Function for MYO7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000146 microfilament motor activity IDA 21687988
GO:0000166 nucleotide binding IEA --
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 11964381
genes like me logo Genes that share ontologies with MYO7A: view
genes like me logo Genes that share phenotypes with MYO7A: view

Human Phenotype Ontology for MYO7A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MYO7A Gene

MGI Knock Outs for MYO7A:

Animal Model Products

miRNA for MYO7A Gene

miRTarBase miRNAs that target MYO7A

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MYO7A Gene

Localization for MYO7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO7A Gene

Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=In the photoreceptor cells, mainly localized in the inner and base of outer segments as well as in the synaptic ending region. Colocalizes with a subset of melanosomes in retinal pigment epithelium cells. Detected at the tip of cochlear hair cell stereocilia. The complex formed by MYO7A, USH1C and USH1G colocalizes with F-actin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO7A Gene COMPARTMENTS Subcellular localization image for MYO7A gene
Compartment Confidence
cytoskeleton 5
cytosol 5
lysosome 5
vacuole 5
plasma membrane 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MYO7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001750 photoreceptor outer segment IDA 8842737
GO:0001917 photoreceptor inner segment IDA 8842737
GO:0005737 cytoplasm IDA 23704327
GO:0005765 lysosomal membrane IDA 16001398
GO:0005829 cytosol IDA 15300860
genes like me logo Genes that share ontologies with MYO7A: view

Pathways & Interactions for MYO7A Gene

genes like me logo Genes that share pathways with MYO7A: view

Gene Ontology (GO) - Biological Process for MYO7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001845 phagolysosome assembly IEA --
GO:0006886 intracellular protein transport IEA --
GO:0006909 phagocytosis IEA --
GO:0007040 lysosome organization IDA 16001398
GO:0007600 sensory perception IEA --
genes like me logo Genes that share ontologies with MYO7A: view

No data available for SIGNOR curated interactions for MYO7A Gene

Drugs & Compounds for MYO7A Gene

(2) Drugs for MYO7A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MYO7A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MYO7A: view

Transcripts for MYO7A Gene

Unigene Clusters for MYO7A Gene

Myosin VIIA:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO7A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^
SP1: -
SP2: -
SP3: -
SP4:
SP5:

ExUns: 25a · 25b ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:
SP5:

Relevant External Links for MYO7A Gene

GeneLoc Exon Structure for
MYO7A
ECgene alternative splicing isoforms for
MYO7A

Expression for MYO7A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYO7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYO7A Gene

This gene is overexpressed in Adrenal Gland (x8.7), Liver (x5.5), Testis (x5.3), and Pituitary (x4.4).

Protein differential expression in normal tissues from HIPED for MYO7A Gene

This gene is overexpressed in Lung (16.3), Adrenal (13.5), Retina (12.7), Liver, secretome (9.6), and Liver (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYO7A Gene



Protein tissue co-expression partners for MYO7A Gene

NURSA nuclear receptor signaling pathways regulating expression of MYO7A Gene:

MYO7A

SOURCE GeneReport for Unigene cluster for MYO7A Gene:

Hs.370421

mRNA Expression by UniProt/SwissProt for MYO7A Gene:

Q13402-MYO7A_HUMAN
Tissue specificity: Expressed in the pigment epithelium and the photoreceptor cells of the retina. Also found in kidney, liver, testis, cochlea, lymphocytes. Not expressed in brain.
genes like me logo Genes that share expression patterns with MYO7A: view

Primer Products

Orthologs for MYO7A Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO7A 34 35
  • 97.95 (n)
cow
(Bos Taurus)
Mammalia MYO7A 34 35
  • 92.44 (n)
dog
(Canis familiaris)
Mammalia MYO7A 34 35
  • 91.99 (n)
oppossum
(Monodelphis domestica)
Mammalia MYO7A 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo7a 34 16 35
  • 89.75 (n)
rat
(Rattus norvegicus)
Mammalia Myo7a 34
  • 89.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYO7A 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYO7A 34 35
  • 80.01 (n)
lizard
(Anolis carolinensis)
Reptilia MYO7A 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo7a 34
  • 77.74 (n)
zebrafish
(Danio rerio)
Actinopterygii myo7ab 35
  • 80 (a)
OneToMany
myo7aa 34 35
  • 77.43 (n)
myo7a 34
fruit fly
(Drosophila melanogaster)
Insecta ck 36 34 35
  • 62.27 (n)
Myo28B1 36
  • 52 (a)
d 36
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea hum-6 36 35
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 58 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9710 34
Species where no ortholog for MYO7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYO7A Gene

ENSEMBL:
Gene Tree for MYO7A (if available)
TreeFam:
Gene Tree for MYO7A (if available)

Paralogs for MYO7A Gene

Paralogs for MYO7A Gene

genes like me logo Genes that share paralogs with MYO7A: view

Variants for MYO7A Gene

Sequence variations from dbSNP and Humsavar for MYO7A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1052030 Usher syndrome 1B (USH1B) [MIM:276900], Likely benign 77,142,737(+) GAGAT(C/T)GGGGC nc-transcript-variant, reference, missense
rs111033174 Usher syndrome 1B (USH1B) [MIM:276900], Pathogenic 77,156,683(+) GAAGA(C/T)GGAGA nc-transcript-variant, reference, missense
rs111033178 Usher syndrome 1B (USH1B) [MIM:276900], Pathogenic 77,190,108(+) GACAC(A/G)GACAC nc-transcript-variant, reference, missense
rs111033181 Usher syndrome 1B (USH1B) [MIM:276900], Likely pathogenic 77,156,022(+) CCACA(A/T)CTTTG nc-transcript-variant, reference, missense
rs111033206 Usher syndrome 1B (USH1B) [MIM:276900], Pathogenic 77,162,854(+) CCAGG(A/G)CACAG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MYO7A Gene

Variant ID Type Subtype PubMed ID
dgv1230n100 CNV gain 25217958
dgv1231n100 CNV gain 25217958
dgv1232n100 CNV gain 25217958
dgv1233n100 CNV gain 25217958
esv1675994 CNV insertion 17803354
esv23051 CNV loss 19812545
esv2663556 CNV deletion 23128226
esv2744803 CNV deletion 23290073
esv2744804 CNV deletion 23290073
esv2744805 CNV deletion 23290073
esv2744806 CNV deletion 23290073
esv2744809 CNV deletion 23290073
esv2744810 CNV deletion 23290073
esv3262 CNV loss 18987735
esv3413403 CNV duplication 20981092
esv3430057 CNV duplication 20981092
esv3548024 CNV deletion 23714750
nsv1047361 CNV gain 25217958
nsv1049476 CNV gain 25217958
nsv1119420 CNV insertion 24896259
nsv1119895 CNV deletion 24896259
nsv1119896 CNV deletion 24896259
nsv1120248 CNV tandem duplication 24896259
nsv1151506 CNV insertion 26484159
nsv509434 CNV insertion 20534489
nsv513327 CNV insertion 21212237
nsv528593 CNV loss 19592680
nsv555450 CNV loss 21841781
nsv555451 CNV loss 21841781
nsv825998 CNV gain 20364138

Variation tolerance for MYO7A Gene

Residual Variation Intolerance Score: 90.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.34; 96.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO7A Gene

Human Gene Mutation Database (HGMD)
MYO7A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYO7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO7A Gene

Disorders for MYO7A Gene

MalaCards: The human disease database

(28) MalaCards diseases for MYO7A Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
usher syndrome, type 1b
  • usher syndrome type i
deafness, autosomal dominant 11
  • autosomal dominant nonsyndromic deafness 11
deafness, autosomal recessive 2
  • autosomal recessive nonsyndromic deafness 2
autosomal dominant non-syndromic sensorineural deafness type dfna
  • autosomal dominant isolated neurosensory deafness type dfna
usher syndrome type ii
  • ush2
- elite association - COSMIC cancer census association via MalaCards
Search MYO7A in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MYO7A_HUMAN
  • Deafness, autosomal dominant, 11 (DFNA11) [MIM:601317]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA11 is characterized by onset after complete speech acquisition and subsequent gradual progression. {ECO:0000269 PubMed:15121790, ECO:0000269 PubMed:15221449, ECO:0000269 PubMed:15300860, ECO:0000269 PubMed:9354784}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Deafness, autosomal recessive, 2 (DFNB2) [MIM:600060]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:9171832, ECO:0000269 PubMed:9171833}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Usher syndrome 1B (USH1B) [MIM:276900]: USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness. {ECO:0000269 PubMed:10094549, ECO:0000269 PubMed:10364543, ECO:0000269 PubMed:10447383, ECO:0000269 PubMed:10930322, ECO:0000269 PubMed:12112664, ECO:0000269 PubMed:15660226, ECO:0000269 PubMed:16679490, ECO:0000269 PubMed:23559863, ECO:0000269 PubMed:24831256, ECO:0000269 PubMed:25798947, ECO:0000269 PubMed:7870171, ECO:0000269 PubMed:8900236, ECO:0000269 PubMed:9002678, ECO:0000269 PubMed:9382091, ECO:0000269 PubMed:9718356}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MYO7A

Genetic Association Database (GAD)
MYO7A
Human Genome Epidemiology (HuGE) Navigator
MYO7A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO7A
genes like me logo Genes that share disorders with MYO7A: view

No data available for Genatlas for MYO7A Gene

Publications for MYO7A Gene

  1. Characterization of Usher syndrome type I gene mutations in an Usher syndrome patient population. (PMID: 15660226) Ouyang X.M. … Liu X.Z. (Hum. Genet. 2005) 3 4 22 46 64
  2. Identification of novel variants in the Myosin VIIA gene of patients with nonsyndromic hearing loss from Taiwan. (PMID: 19299023) Su M.C. … Li S.Y. (Int. J. Pediatr. Otorhinolaryngol. 2009) 3 22 46 64
  3. Pigmentation-related genes and their implication in malignant melanoma susceptibility. (PMID: 19320733) Fernandez L.P. … Ribas G. (Exp. Dermatol. 2009) 3 22 46 64
  4. Survey of the frequency of USH1 gene mutations in a cohort of Usher patients shows the importance of cadherin 23 and protocadherin 15 genes and establishes a detection rate of above 90%. (PMID: 16679490) Roux A.-F. … Claustres M. (J. Med. Genet. 2006) 3 4 22 64
  5. Modifier controls severity of a novel dominant low-frequency MyosinVIIA (MYO7A) auditory mutation. (PMID: 15121790) Street V.A. … Kiemele K.L. (J. Med. Genet. 2004) 3 4 22 64

Products for MYO7A Gene

Sources for MYO7A Gene

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