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Aliases for MYO5C Gene

Aliases for MYO5C Gene

  • Myosin VC 2 3 5
  • Myosin 5C 2 3
  • Unconventional Myosin-Vc 3
  • Myosin-Vc 3

External Ids for MYO5C Gene

Previous GeneCards Identifiers for MYO5C Gene

  • GC15M048042
  • GC15M045531
  • GC15M050063
  • GC15M050200
  • GC15M050271
  • GC15M052484
  • GC15M029315
  • GC15M052417
  • GC15M052688
  • GC15M054215
  • GC15M054936
  • GC15M055377

Summaries for MYO5C Gene

GeneCards Summary for MYO5C Gene

MYO5C (Myosin VC) is a Protein Coding gene. Among its related pathways are PAK Pathway and Sweet Taste Signaling. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is MYO5A.

UniProtKB/Swiss-Prot for MYO5C Gene

  • May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO5C Gene

Genomics for MYO5C Gene

Regulatory Elements for MYO5C Gene

Enhancers for MYO5C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G052286 1.7 FANTOM5 Ensembl ENCODE 27.3 +7.2 7170 3.3 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 MYO5C GNB5 ARPP19 LOC105370819 MIR1266
GH15G052231 1.8 FANTOM5 Ensembl ENCODE dbSUPER 22.1 +61.9 61946 5.2 HDGF ZFP64 SIN3A ZBTB7B ZNF121 GLIS2 ELK1 FOS ZNF202 JUNB MYO5C GNB5 MIR1266 ENSG00000259935 SCG3 ENSG00000259709 TMOD3 FAM214A LOC105370820 GC15M056432
GH15G052280 0.9 ENCODE 21.8 +14.5 14538 1.9 FOXA2 ARID4B THRB ZNF48 RAD21 RARA MIXL1 SP5 PPARG ZNF592 MYO5C MIR1266 LOC105370819
GH15G052293 0.9 ENCODE 21.2 +0.7 670 2.6 ARID4B SIN3A ZNF48 YY1 ZNF121 GLIS2 YY2 NFYC KAT8 MBD2 MYO5C LOC105370819
GH15G051841 2 FANTOM5 Ensembl ENCODE dbSUPER 5.7 +451.2 451161 6.9 HDGF PKNOX1 FOXA2 CREB3L1 MLX ARNT ARID4B SIN3A DMAP1 FEZF1 LYSMD2 TMOD2 TMOD3 DMXL2 MAPK6 ENSG00000259178 MYO5C ENSG00000277677 ENSG00000274954
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYO5C on UCSC Golden Path with GeneCards custom track

Promoters for MYO5C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000076706 198 801 TBP NFIB FUS ARID4B SIN3A ZNF48 ZSCAN9 RAD21 ZEB1 YY1

Genomic Location for MYO5C Gene

Chromosome:
15
Start:
52,192,318 bp from pter
End:
52,295,798 bp from pter
Size:
103,481 bases
Orientation:
Minus strand

Genomic View for MYO5C Gene

Genes around MYO5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO5C Gene

Proteins for MYO5C Gene

  • Protein details for MYO5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQX4-MYO5C_HUMAN
    Recommended name:
    Unconventional myosin-Vc
    Protein Accession:
    Q9NQX4
    Secondary Accessions:
    • Q6P1W8

    Protein attributes for MYO5C Gene

    Size:
    1742 amino acids
    Molecular mass:
    202810 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MYO5C Gene

    Alternative splice isoforms for MYO5C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO5C Gene

Post-translational modifications for MYO5C Gene

  • Ubiquitination at posLast=911911
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MYO5C Gene

Domains & Families for MYO5C Gene

Gene Families for MYO5C Gene

Suggested Antigen Peptide Sequences for MYO5C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQX4

UniProtKB/Swiss-Prot:

MYO5C_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO5C: view

Function for MYO5C Gene

Molecular function for MYO5C Gene

UniProtKB/Swiss-Prot Function:
May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues.

Gene Ontology (GO) - Molecular Function for MYO5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYO5C: view
genes like me logo Genes that share phenotypes with MYO5C: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYO5C Gene

Localization for MYO5C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYO5C gene
Compartment Confidence
extracellular 5
cytoskeleton 4
cytosol 4
nucleus 2
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MYO5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016459 myosin complex IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with MYO5C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYO5C Gene

Pathways & Interactions for MYO5C Gene

genes like me logo Genes that share pathways with MYO5C: view

Gene Ontology (GO) - Biological Process for MYO5C Gene

None

No data available for SIGNOR curated interactions for MYO5C Gene

Drugs & Compounds for MYO5C Gene

No Compound Related Data Available

Transcripts for MYO5C Gene

Unigene Clusters for MYO5C Gene

Myosin VC:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO5C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - -
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for MYO5C Gene

GeneLoc Exon Structure for
MYO5C
ECgene alternative splicing isoforms for
MYO5C

Expression for MYO5C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYO5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYO5C Gene

This gene is overexpressed in Pancreas (x4.2).

Protein differential expression in normal tissues from HIPED for MYO5C Gene

This gene is overexpressed in Nasal epithelium (35.4) and Bone (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYO5C Gene



NURSA nuclear receptor signaling pathways regulating expression of MYO5C Gene:

MYO5C

SOURCE GeneReport for Unigene cluster for MYO5C Gene:

Hs.487036

mRNA Expression by UniProt/SwissProt for MYO5C Gene:

Q9NQX4-MYO5C_HUMAN
Tissue specificity: Expressed chiefly in non-neuronal tissues. Particularly abundant in epithelial and glandular tissues including pancreas, prostate, mammary, stomach, colon and lung.

Evidence on tissue expression from TISSUES for MYO5C Gene

  • Nervous system(4.3)
  • Eye(2.8)
genes like me logo Genes that share expression patterns with MYO5C: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYO5C Gene

Orthologs for MYO5C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYO5C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO5C 34 35
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia MYO5C 34 35
  • 91.17 (n)
oppossum
(Monodelphis domestica)
Mammalia MYO5C 35
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYO5C 35
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myo5c 34
  • 85.32 (n)
mouse
(Mus musculus)
Mammalia Myo5c 34 16 35
  • 85.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYO5C 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYO5C 34 35
  • 75.67 (n)
lizard
(Anolis carolinensis)
Reptilia MYO5C 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo5c 34
  • 70.09 (n)
Str.12937 34
zebrafish
(Danio rerio)
Actinopterygii myo5c 34 35
  • 65.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta didum 36 35
  • 37 (a)
d 36
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea hum-2 36 35
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO2 35
  • 34 (a)
ManyToMany
MYO4 35
  • 32 (a)
ManyToMany
SGM1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons XID 34
  • 47.42 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes myo51 34
  • 46.87 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10542 35
  • 41 (a)
OneToMany
Species where no ortholog for MYO5C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYO5C Gene

ENSEMBL:
Gene Tree for MYO5C (if available)
TreeFam:
Gene Tree for MYO5C (if available)

Paralogs for MYO5C Gene

Variants for MYO5C Gene

Sequence variations from dbSNP and Humsavar for MYO5C Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000002361 -- 52,236,545(+) ATGGC(A/G)CATGC intron-variant
rs1000090425 -- 52,260,784(+) AGAAC(C/T)AGAAC intron-variant
rs1000128970 -- 52,286,021(+) TGAGA(C/T)GTGGG intron-variant
rs1000157347 -- 52,259,435(+) AAAAG(A/G)AAAAA intron-variant
rs1000184401 -- 52,202,249(+) GCGCA(C/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO5C Gene

Variant ID Type Subtype PubMed ID
dgv1212n106 CNV deletion 24896259
esv1288276 CNV deletion 17803354
esv2403082 CNV deletion 18987734
esv2637818 CNV deletion 19546169
esv2749694 CNV deletion 23290073
esv3552449 CNV deletion 23714750
esv7451 CNV loss 19470904
esv999998 CNV deletion 20482838
nsv1537 CNV deletion 18451855
nsv471244 CNV gain 18288195
nsv833005 CNV gain 17160897
nsv957980 CNV deletion 24416366

Variation tolerance for MYO5C Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.83; 93.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO5C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYO5C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO5C Gene

Disorders for MYO5C Gene

Relevant External Links for MYO5C

Genetic Association Database (GAD)
MYO5C
Human Genome Epidemiology (HuGE) Navigator
MYO5C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO5C

No disorders were found for MYO5C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYO5C Gene

Publications for MYO5C Gene

  1. Human myosin-Vc is a novel class V myosin expressed in epithelial cells. (PMID: 11870218) Rodriguez O.C. … Cheney R.E. (J. Cell Sci. 2002) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Myosin Vc is a molecular motor that functions in secretory granule trafficking. (PMID: 19741097) Jacobs D.T. … Cheney R.E. (Mol. Biol. Cell 2009) 3 22 64
  4. Human myosin Vc is a low duty ratio nonprocessive motor. (PMID: 18079121) Watanabe S. … Ikebe M. (J. Biol. Chem. 2008) 3 22 64
  5. Human myosin Vc is a low duty ratio, nonprocessive molecular motor. (PMID: 18201966) Takagi Y. … KovA!cs M. (J. Biol. Chem. 2008) 3 22 64

Products for MYO5C Gene

Sources for MYO5C Gene

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