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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYO5C Gene

protein-coding   GIFtS: 53
GCID: GC15M052484

myosin VC
 Explore 4 diseases affiliated with
MYO5C via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MYO5C    

Aliases
for MYO5C gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Myosin VC1 2
MGC749691
Myosin 5C2
Myosin-Vc1
Unconventional Myosin-Vc2

External Ids:    HGNC: 76041   Entrez Gene: 559302   Ensembl: ENSG000001288337   OMIM: 6100225   UniProtKB: Q9NQX43   

Export aliases for MYO5C gene to outside databases

Previous GC identifers: GC15M048042 GC15M045531 GC15M050063 GC15M050200 GC15M050271 GC15M029315


Summaries
for MYO5C gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MYO5C_HUMAN, Q9NQX4
Function: May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many
physiologically crucial tissues




Genomic Views
for MYO5C gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYO5C gene promoter:
         Sox5   Lmo2   IRF-1   AP-4   Evi-1   CBF-B   POU2F1   POU2F1a   CP1A   CP1C   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYO5C promoter sequence
   Search SABiosciences Chromatin IP Primers for MYO5C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYO5C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21

MYO5C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO5C gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M052484:  view genomic region     (about GC identifiers)

Start:
 52,484,515 bp from pter      End:
 52,587,995 bp from pter
Size:
 103,481 bases      Orientation:
 minus strand

Proteins
for MYO5C gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MYO5C_HUMAN, Q9NQX4 (See protein sequence)
Recommended Name: Unconventional myosin-Vc  
Size: 1742 amino acids; 202810 Da

Explore the universe of human proteins at neXtProt for MYO5C: NX_Q9NQX4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NQX4

    • MYO5C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061198.2  
    ENSEMBL proteins: 
     ENSP00000261839   ENSP00000453641   ENSP00000453517   ENSP00000454064   ENSP00000453514  
     ENSP00000410582  

    Human Recombinant Protein Products: 
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    Novus Biologicals MYO5C Protein
    Novus Biologicals MYO5C Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MYO5C

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016459myosin complex IEA--


    MYO5C for ontologies           About GeneDecksing



    MYO5C Antibody Products: 
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    Uscn Antibodies for MYO5C
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    Uscn ELISAs and CLIAs for MYO5C

    Protein Domains /
    Families
    for MYO5C gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MYO5C for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000048 IQ_motif_EF-hand-BS
     IPR018444 Dil_domain
     IPR002710 Dilute
     IPR001609 Myosin_head_motor_dom

    Graphical View of Domain Structure for InterPro Entry Q9NQX4

    ProtoNet protein and cluster: Q9NQX4

    3 Blocks protein families:
    IPB000048 IQ calmodulin-binding region
    IPB002710 Dilute (DIL) domain
    IPB004009 Myosin N-terminal SH3-like domain


    UniProtKB/Swiss-Prot: MYO5C_HUMAN, Q9NQX4
    Similarity: Contains 1 dilute domain
    Similarity: Contains 5 IQ domains
    Similarity: Contains 1 myosin head-like domain


    Function
    for MYO5C gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MYO5C_HUMAN, Q9NQX4
    Function: May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many
    physiologically crucial tissues

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYO5C
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate MYO5C (see all 17):
    hsa-miR-600 hsa-miR-3140-3p hsa-miR-520d-5p hsa-miR-130a* hsa-miR-575 hsa-miR-23c hsa-miR-4282 hsa-miR-7
    SwitchGear 3'UTR luciferase reporter plasmid: MYO5C 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYO5C (see all 7)
    OriGene shRNA RFP: MYO5C
    OriGene siRNA: MYO5C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYO5C

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MYO5C

    Clone
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    GenScript: all cDNA clones in your preferred vector: MYO5C (NM_018728)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYO5C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO5C 

    Cell Line
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    Search LifeMap BioReagents cell lines for MYO5C

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO5C

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0003779actin binding IEA--
    GO:0005516calmodulin binding IEA--
    GO:0005524ATP binding IEA--
    GO:0051015actin filament binding ----


    MYO5C for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MYO5C:
     Decreased viability with pacli  Increased cilium length after  


    Pathways & Interactions
    for MYO5C gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PAK Pathway
    		PAK Pathway1.00
    		Epithelial Adherens Junctions0.36
    		Antioxidant Action of Vitamin-C0.56
    2Fc-GammaR-Mediated Phagocytosis in Macrophages
    		Fc-GammaR-Mediated Phagocytosis in Macrophages1.00
    		RhoGDI Pathway0.33
    3Actin Nucleation by ARP-WASP Complex
    		Actin Nucleation by ARP-WASP Complex1.00
    		RhoA Pathway0.35
    4Sweet Taste Signaling
    		Cellular Effects of Sildenafil0.46
    5Integrin Pathway
    		Transendothelial Migration of Leukocytes0.38

    5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYO5C (see all 10)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYO5C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for MYO5C (Q9NQX43 ENSP000002618394) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    WNK1Q9H4A33I2D: score=1 
    MYL6BENSP000002074374STRING: ENSP00000207437
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Drugs & Compounds
    for MYO5C gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MYO5C
    Search CenterWatch for drugs/clinical trials and news about MYO5C 

    Transcripts
    for MYO5C gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MYO5C gene: 
    NM_018728.3  

    Unigene Cluster for MYO5C:

    Myosin VC
    Hs.487036  [show with all ESTs]
    Unigene Representative Sequence: NM_018728
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261839(uc010bff.3 uc010uga.2 uc010ugc.2) ENST00000560809
    ENST00000559696 ENST00000558902 ENST00000559434 ENST00000559459 ENST00000558242
    ENST00000541028 ENST00000558479 ENST00000443683(uc010ugb.2)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MYO5C
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYO5C
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate MYO5C (see all 17):
    hsa-miR-600 hsa-miR-3140-3p hsa-miR-520d-5p hsa-miR-130a* hsa-miR-575 hsa-miR-23c hsa-miR-4282 hsa-miR-7
    SwitchGear 3'UTR luciferase reporter plasmid: MYO5C 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYO5C (see all 7)
    OriGene shRNA RFP: MYO5C
    OriGene siRNA: MYO5C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYO5C
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYO5C (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYO5C
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MYO5C (NM_018728)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYO5C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO5C 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYO5C
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYO5C
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYO5C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYO5C

    Additional cDNA sequence: 

    AF161352.1 AF272390.1 AK131493.1 AK301079.1 AK304136.1 BC064841.1 

    8 DOTS entries:

    DT.91725655  DT.102830757  DT.92053659  DT.102830756  DT.306996  DT.313184  DT.91700611  DT.95180905 

    24/80 AceView cDNA sequences (see all 80):

    AW474489 AI051183 CA489061 T11378 BM852582 BM829813 BC064841 L29144 
    BM827711 AA307499 CA391411 AF161352 AF150230 AW440382 CF528682 AI884584 
    BQ007481 AK131493 CA435743 BX482532 BM312787 BM978870 BP359445 AF272390 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MYO5C (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                          -     -                                                                           
    SP2:                                                                                -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                -                                                                           
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for MYO5C

    Expression
    for MYO5C gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYO5C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAAAATGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MYO5C expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeInterscapular Brown Adipose DepotAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium

    See MYO5C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYO5C

    SOURCE GeneReport for Unigene cluster: Hs.487036

    UniProtKB/Swiss-Prot: MYO5C_HUMAN, Q9NQX4
    Tissue specificity: Expressed chiefly in non-neuronal tissues. Particularly abundant in epithelial and glandular
    tissues including pancreas, prostate, mammary, stomach, colon and lung

        SABiosciences Custom PCR Arrays for MYO5C
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO5C

    Orthologs
    for MYO5C gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MYO5C gene from 8/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MYO5C1 myosin VC 75.67(n)
    80.25(a)    		   430027  XM_003641843.1  XP_003641891.1 
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.129372 Transcribed sequence with moderate similarity to protein more 76.59(n)    BX721377.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii myo5c1 myosin VC 65.71(n)
    64.73(a)    		   562676  XM_686051.3  XP_691143.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta didum3 myosin ATPase 37(a)
    (best of 2)    		   2 43D3   --
    worm
    (Caenorhabditis elegans)    		 Secernentea hum-23   -- 34(a)   V(9388744-9402300)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes SGM1(YJR134C)4
    MYO21    		 Protein of unknown function, required for wild-type more4
    Myo2p1    		 50.68(n)1
    43.51(a)1    		   10(675852-673729)4
    8545041  NP_014971.11  8535984 
     NP_012668.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons XIK1 Myosin family protein with Dil domain 47.8(n)
    39.88(a)    		   832171  NM_122056.3  NP_197549.3 
    rice
    (Oryza sativa)    		 Liliopsida NM_196325.12   -- 75.81(n)    NM_196325.1 


    ENSEMBL Gene Tree for MYO5C (if available)
    TreeFam Gene Tree for MYO5C (if available) 

    Paralogs
    for MYO5C gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYO5C gene
    MYO3A2  MYO9A2  MYO102  MYO15A2  MYO7A2  MYO9B2  MYO162  MYO5A2  
    MYO7B2  MYO5B2  MYO62  MYO3B2  
    18/36 SIMAP similar genes for MYO5C using alignment to 6 protein entries:     MYO5C_HUMAN (see all proteins) (see all similar genes):
    MYO5A    MYO5B    MYO1B    MYO9A    MYO1H    MYO1A
    MYO1G    MYO7A    MYH11    MYO1C    MYO1D    MYH10
    MYO1F variant protein    MYO1E    MYO6    MYO10    MYO9B variant protein    MYH2

    MYO5C for paralogs           About GeneDecksing



    Genomic Variants
    for MYO5C gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1897 NCBI SNPs in MYO5C are shown (see all 1897)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs796106451,2
    		C,F,--29317298(+) ACAGCT/CATCTC 1 -- int12Minor allele frequency- C:0.06WA NA 238
    rs750346591,2
    		F,--29318098(+) TGAAAG/CTGTCT 1 -- int11Minor allele frequency- C:0.09WA 118
    rs740156261,2
    		C,--29318803(+) GGGAGC/GAAAGG 1 -- int12Minor allele frequency- G:0.04WA 120
    rs169647601,2
    		C,F,H,--29319849(+) GGGCCG/AGAACA 1 -- int116Minor allele frequency- A:0.05NA NS EA WA 2184
    rs133803641,2
    		C,F,H,--29320124(+) CAATCC/TACTGT 1 -- int17Minor allele frequency- T:0.03NS EA WA CSA 524
    rs748492261,2
    		--29320600(+) AAAATC/ATGTAG 1 -- int11Minor allele frequency- A:0.01EA 120
    rs129026051,2
    		H--29322724(+) caggtT/Ggaaac 1 -- int14Minor allele frequency- G:0.00NS EA 380
    rs740156271,2
    		C,F,--29322853(+) CTATTC/ATCTCA 1 -- int13Minor allele frequency- A:0.14WA CSA 122
    rs581332931,2
    		C,--29322957(+) TGGAGG/AATCTG 1 -- int12Minor allele frequency- A:0.04WA 120
    rs80248461,2
    		C,--29323012(+) gagacA/Gtctgc 1 -- int13Minor allele frequency- G:0.07CSA WA NA 240

    HapMap Linkage Disequilibrium report for MYO5C (52484515 - 52587995 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for MYO5C
         1 CNV: 102104
         4 Indels: 61445 45347 40099 25528

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    Disorders / Diseases
    for MYO5C gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MYO5C for disorders           About GeneDecksing

    OMIM gene information: 610022    OMIM disorders: --

    4 diseases for MYO5C:    About MalaCards
    pancreatitis    malaria    prostatitis    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: MYO5C (1 document)

    Export disorders for MYO5C gene to outside databases

    Publications
    for MYO5C gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYO5C gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with MYO5C)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human myosin-Vc is a novel class V myosin expressed in epithelial cells. (PubMed id 11870218)1, 2, 3, 9 Rodriguez O.C. and Cheney R.E. (2002)
    2. Human myosin Vc is a low duty ratio, nonprocessive molecular motor. (PubMed id 18201966)1, 9 Takagi Y....Kovacs M. (2008)
    3. Human myosin Vc is a low duty ratio nonprocessive motor. (PubMed id 18079121)1, 9 Watanabe S....Ikebe M. (2008)
    4. Myosin Vc is a molecular motor that functions in secr etory granule trafficking. (PubMed id 19741097)1, 9 Jacobs D.T....Cheney R.E. (2009)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Alternative splicing in class v myosins determines association with rab10. (PubMed id 19008234)1 Roland J.T....Goldenring J.R. (2009)
    9. Myosin Vc, a member of the actin motor family associa ted with Rab8, is involved in the release of DV2 from HepG2 cells. (PubMed id 19641326)1 Xu X.F....An J. (2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

    External Searches for MYO5C gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing MYO5C gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55930 HGNC: 7604 AceView: MYO5C Ensembl:ENSG00000128833 euGenes: HUgn55930
    ECgene: MYO5C H-InvDB: MYO5C

    Other Databases showing MYO5C gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MYO5C gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYO5C Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MYO5C gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MYO5C gene:
    Search GeneIP for patents involving MYO5C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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