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Aliases for MYO5C Gene

Aliases for MYO5C Gene

  • Myosin VC 2 3
  • Myosin 5C 2 3
  • Unconventional Myosin-Vc 3
  • Myosin-Vc 3

External Ids for MYO5C Gene

Summaries for MYO5C Gene

GeneCards Summary for MYO5C Gene

MYO5C (Myosin VC) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and PAK Pathway. GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYO7A.

UniProtKB/Swiss-Prot for MYO5C Gene

  • May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO5C Gene

Genomics for MYO5C Gene

Genomic Location for MYO5C Gene

Start:
52,192,318 bp from pter
End:
52,295,798 bp from pter
Size:
103,481 bases
Orientation:
Minus strand

Genomic View for MYO5C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYO5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO5C Gene

Regulatory Elements for MYO5C Gene

Proteins for MYO5C Gene

  • Protein details for MYO5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQX4-MYO5C_HUMAN
    Recommended name:
    Unconventional myosin-Vc
    Protein Accession:
    Q9NQX4
    Secondary Accessions:
    • Q6P1W8

    Protein attributes for MYO5C Gene

    Size:
    1742 amino acids
    Molecular mass:
    202810 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MYO5C Gene

    Alternative splice isoforms for MYO5C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO5C Gene

Proteomics data for MYO5C Gene at MOPED

Post-translational modifications for MYO5C Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys911

Other Protein References for MYO5C Gene

No data available for DME Specific Peptides for MYO5C Gene

Domains for MYO5C Gene

Gene Families for MYO5C Gene

HGNC:
  • MYOV :Myosins / Myosin superfamily : Class V

UniProtKB/Swiss-Prot:

MYO5C_HUMAN
Domain:
  • Contains 1 dilute domain.:
    • Q9NQX4
  • Contains 5 IQ domains.:
    • Q9NQX4
  • Contains 1 myosin motor domain.:
    • Q9NQX4
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.:
    • Q9NQX4
genes like me logo Genes that share domains with MYO5C: view

Function for MYO5C Gene

Molecular function for MYO5C Gene

UniProtKB/Swiss-Prot Function: May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues

Gene Ontology (GO) - Molecular Function for MYO5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005515 protein binding --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYO5C: view

Phenotypes for MYO5C Gene

genes like me logo Genes that share phenotypes with MYO5C: view

miRNA for MYO5C Gene

miRTarBase miRNAs that target MYO5C

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MYO5C Gene

Localization for MYO5C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO5C Gene COMPARTMENTS Subcellular localization image for MYO5C gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MYO5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016459 myosin complex IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with MYO5C: view

Pathways for MYO5C Gene

genes like me logo Genes that share pathways with MYO5C: view

Gene Ontology (GO) - Biological Process for MYO5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with MYO5C: view

Transcripts for MYO5C Gene

Unigene Clusters for MYO5C Gene

Myosin VC:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYO5C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - -
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for MYO5C Gene

GeneLoc Exon Structure for
MYO5C
ECgene alternative splicing isoforms for
MYO5C

Expression for MYO5C Gene

mRNA expression in normal human tissues for MYO5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYO5C Gene

This gene is overexpressed in Pancreas (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYO5C Gene

SOURCE GeneReport for Unigene cluster for MYO5C Gene Hs.487036

mRNA Expression by UniProt/SwissProt for MYO5C Gene

Q9NQX4-MYO5C_HUMAN
Tissue specificity: Expressed chiefly in non-neuronal tissues. Particularly abundant in epithelial and glandular tissues including pancreas, prostate, mammary, stomach, colon and lung.
genes like me logo Genes that share expressions with MYO5C: view

Orthologs for MYO5C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYO5C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO5C 36
  • 99.48 (n)
  • 99.43 (a)
MYO5C 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYO5C 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO5C 36
  • 91.17 (n)
  • 93.13 (a)
MYO5C 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo5c 36
  • 85.25 (n)
  • 89.27 (a)
Myo5c 16
Myo5c 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYO5C 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYO5C 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myo5c 36
  • 85.32 (n)
  • 89.78 (a)
chicken
(Gallus gallus)
Aves MYO5C 36
  • 75.67 (n)
  • 80.25 (a)
MYO5C 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYO5C 37
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo5c 36
  • 70.09 (n)
  • 72.87 (a)
Str.12937 36
zebrafish
(Danio rerio)
Actinopterygii myo5c 36
  • 65.69 (n)
  • 64.73 (a)
myo5c 37
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta didum 37
  • 36 (a)
OneToMany
d 38
  • 28 (a)
didum 38
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea hum-2 37
  • 33 (a)
OneToMany
hum-2 38
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO2 37
  • 34 (a)
ManyToMany
MYO4 37
  • 32 (a)
ManyToMany
SGM1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons XID 36
  • 47.42 (n)
  • 39 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes myo51 36
  • 46.87 (n)
  • 39.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10542 37
  • 41 (a)
OneToMany
Species with no ortholog for MYO5C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYO5C Gene

ENSEMBL:
Gene Tree for MYO5C (if available)
TreeFam:
Gene Tree for MYO5C (if available)

Paralogs for MYO5C Gene

Paralogs for MYO5C Gene

genes like me logo Genes that share paralogs with MYO5C: view

Variants for MYO5C Gene

Sequence variations from dbSNP and Humsavar for MYO5C Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1011050 -- 52,210,885(+) AATCC(C/T)GCCCT intron-variant
rs1011051 -- 52,211,060(+) GTCCA(A/G)TCATT intron-variant
rs2001857 -- 52,236,620(+) GCAGT(A/G)AGCCG intron-variant
rs2001858 -- 52,236,634(+) TTGCG(C/T)CACCG intron-variant
rs2007854 -- 52,236,310(+) GCACC(A/G)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO5C Gene

Variant ID Type Subtype PubMed ID
nsv471244 CNV Gain 18288195
nsv833005 CNV Gain 17160897
nsv904220 CNV Loss 21882294
nsv1537 CNV Loss 18451855
esv2637818 CNV Deletion 19546169
esv2403082 CNV Deletion 18987734
esv2749694 CNV Deletion 23290073
esv999998 CNV Deletion 20482838
esv7451 CNV Loss 19470904
esv1288276 CNV Deletion 17803354

Relevant External Links for MYO5C Gene

HapMap Linkage Disequilibrium report
MYO5C

Disorders for MYO5C Gene

Relevant External Links for MYO5C

Genetic Association Database (GAD)
MYO5C
Human Genome Epidemiology (HuGE) Navigator
MYO5C
genes like me logo Genes that share disorders with MYO5C: view

No data available for UniProtKB/Swiss-Prot for MYO5C Gene

Publications for MYO5C Gene

  1. Human myosin-Vc is a novel class V myosin expressed in epithelial cells. (PMID: 11870218) Rodriguez O.C. … Cheney R.E. (J. Cell Sci. 2002) 2 3 4 23
  2. Human myosin Vc is a low duty ratio nonprocessive motor. (PMID: 18079121) Watanabe S. … Ikebe M. (J. Biol. Chem. 2008) 3 23
  3. Human myosin Vc is a low duty ratio, nonprocessive molecular motor. (PMID: 18201966) Takagi Y. … KovA!cs M. (J. Biol. Chem. 2008) 3 23
  4. Myosin Vc is a molecular motor that functions in secretory granule trafficking. (PMID: 19741097) Jacobs D.T. … Cheney R.E. (Mol. Biol. Cell 2009) 3 23
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for MYO5C Gene

Sources for MYO5C Gene

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