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MYO5C Gene

protein-coding   GIFtS: 55
GCID: GC15M052484

Myosin VC

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin VC1 2
Myosin 5C1 2
myosin-Vc2
Unconventional Myosin-Vc2

External Ids:    HGNC: 76041   Entrez Gene: 559302   Ensembl: ENSG000001288337   OMIM: 6100225   UniProtKB: Q9NQX43   

Export aliases for MYO5C gene to outside databases

Previous GC identifers: GC15M048042 GC15M045531 GC15M050063 GC15M050200 GC15M050271 GC15M029315


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYO5C Gene:
MYO5C (myosin VC) is a protein-coding gene. GO annotations related to this gene include motor activity and actin binding. An important paralog of this gene is MYO3A.

UniProtKB/Swiss-Prot: MYO5C_HUMAN, Q9NQX4
Function: May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many
physiologically crucial tissues




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYO5C gene promoter:
         Sox5   Lmo2   IRF-1   AP-4   Evi-1   CBF-B   POU2F1   POU2F1a   CP1A   CP1C   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYO5C promoter sequence
   Search Chromatin IP Primers for MYO5C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYO5C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21

MYO5C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO5C gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M052484:  view genomic region     (about GC identifiers)

Start:
52,484,515 bp from pter      End:
52,587,995 bp from pter
Size:
103,481 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MYO5C_HUMAN, Q9NQX4 (See protein sequence)
Recommended Name: Unconventional myosin-Vc  
Size: 1742 amino acids; 202810 Da
1 PDB 3D structure from and Proteopedia for MYO5C:
4L8T (3D)    

Explore the universe of human proteins at neXtProt for MYO5C: NX_Q9NQX4

Explore proteomics data for MYO5C at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys911
  • Modification sites at PhosphoSitePlus

  • See MYO5C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061198.2  
    ENSEMBL proteins: 
     ENSP00000261839   ENSP00000453641   ENSP00000453517   ENSP00000454064   ENSP00000453514  
     ENSP00000410582  

    MYO5C Human Recombinant Protein Products:

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    Novus Biologicals MYO5C Protein
    Novus Biologicals MYO5C Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYO5C

     
    Search eBioscience for Proteins for MYO5C 

     
    antibodies-online proteins for MYO5C (2 products) 

     
    antibodies-online peptides for MYO5C

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    antibodies-online antibodies for MYO5C 

    MYO5C Assay Products:

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    Cloud-Clone Corp. ELISAs for MYO5C
    Cloud-Clone Corp. CLIAs for MYO5C
    Search eBioscience for ELISAs for MYO5C 
    antibodies-online kits for MYO5C (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MYOV: Myosins / Myosin superfamily : Class V

    5 InterPro protein domains:
     IPR018444 Dil_domain
     IPR002710 Dilute
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS
     IPR001609 Myosin_head_motor_dom

    Graphical View of Domain Structure for InterPro Entry Q9NQX4

    ProtoNet protein and cluster: Q9NQX4

    3 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB002710 Dilute (DIL) domain
    IPB004009 Myosin N-terminal SH3-like domain


    UniProtKB/Swiss-Prot: MYO5C_HUMAN, Q9NQX4
    Similarity: Contains 1 dilute domain
    Similarity: Contains 5 IQ domains
    Similarity: Contains 1 myosin head-like domain


    Find genes that share domains with MYO5C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYO5C_HUMAN, Q9NQX4
    Function: May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many
    physiologically crucial tissues

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with MYO5C           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MYO5C:
     Decreased viability with pacli  Increased cilium length after  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MYO5C

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYO5C:
    hsa-mir-92a-3p (MIRT049157), hsa-mir-320a (MIRT044447), hsa-mir-1260b (MIRT052745)

    Block miRNA regulation of human, mouse, rat MYO5C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYO5C (see all 17):
    hsa-miR-600 hsa-miR-3140-3p hsa-miR-520d-5p hsa-miR-130a* hsa-miR-575 hsa-miR-23c hsa-miR-4282 hsa-miR-7
    SwitchGear 3'UTR luciferase reporter plasmidMYO5C 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MYO5C

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MYO5C (NM_018728)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYO5C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO5C

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MYO5C 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO5C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    nucleus2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016459myosin complex IEA--

    Find genes that share ontologies with MYO5C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYO5C About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    2Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    3RhoGDI Pathway
    Fc-GammaR-Mediated Phagocytosis in Macrophages0.33
    RhoGDI Pathway0.33
    4Sweet Taste Signaling
    Cellular Effects of Sildenafil0.46
    5Integrin Pathway
    Transendothelial Migration of Leukocytes0.38

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYO5C (see all 10)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYO5C
    Interactions:

        GeneGlobe Interaction Network for MYO5C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYO5C (Q9NQX43 ENSP000002618394) via UniProtKB, MINT, STRING, and/or I2D (see all 138)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    WNK1Q9H4A33I2D: score=1 
    MYL6BENSP000002074374STRING: ENSP00000207437
    MLPHENSP000002646054STRING: ENSP00000264605
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYO5C



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYO5C gene: 
    NM_018728.3  

    Unigene Cluster for MYO5C:

    Myosin VC
    Hs.487036  [show with all ESTs]
    Unigene Representative Sequence: NM_018728
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261839(uc010bff.3 uc010uga.2 uc010ugc.2) ENST00000560809
    ENST00000559696 ENST00000558902 ENST00000559434 ENST00000559459 ENST00000558242
    ENST00000541028 ENST00000558479 ENST00000443683(uc010ugb.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MYO5C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYO5C (see all 17):
    hsa-miR-600 hsa-miR-3140-3p hsa-miR-520d-5p hsa-miR-130a* hsa-miR-575 hsa-miR-23c hsa-miR-4282 hsa-miR-7
    SwitchGear 3'UTR luciferase reporter plasmidMYO5C 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MYO5C
    Predesigned siRNA for gene silencing in human, mouse, rat MYO5C
    Clone
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    OriGene clones in human, mouse for MYO5C (see all 5)
    OriGene ORF clones in mouse, rat for MYO5C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYO5C (NM_018728)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYO5C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO5C
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MYO5C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYO5C
      QuantiTect SYBR Green Assays in human, mouse, rat MYO5C
      QuantiFast Probe-based Assays in human, mouse, rat MYO5C

    Additional mRNA sequence: 

    AF161352.1 AF272390.1 AK131493.1 AK301079.1 AK304136.1 BC064841.1 

    9 DOTS entries:

    DT.91725655  DT.102830757  DT.97837465  DT.92053659  DT.102830756  DT.306996  DT.313184  DT.91700611 
    DT.95180905 

    Selected AceView cDNA sequences (see all 80):

    BC064841 BM852582 BM829813 BM827711 L29144 CA391411 AA307499 AI051183 
    AW474489 CA489061 T11378 BQ286023 NM_018728 BQ012037 AA130046 CD723110 
    AL699355 AW130944 AI653656 BM768437 BM832639 BM821385 AW850757 AI784396 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYO5C (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                          -     -                                                                           
    SP2:                                                                                -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                -                                                                           
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for MYO5C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYO5C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAAATGAA
    MYO5C Expression
    About this image


    MYO5C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Perivascular Adipose
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Brain (Nervous System)
             Mature Choroid Plexus Cells Choroid Plexus
     
     Lung (Respiratory System)
    MYO5C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYO5C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.487036

    UniProtKB/Swiss-Prot: MYO5C_HUMAN, Q9NQX4
    Tissue specificity: Expressed chiefly in non-neuronal tissues. Particularly abundant in epithelial and glandular
    tissues including pancreas, prostate, mammary, stomach, colon and lung

        Custom PCR Arrays for MYO5C
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYO5C
    QuantiTect SYBR Green Assays in human, mouse, rat MYO5C
    QuantiFast Probe-based Assays in human, mouse, rat MYO5C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO5C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MYO5C gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myo5c1 , 5 myosin VC1, 5 85.25(n)1
    89.27(a)1
      9 (42.30 cM)5
    2089431  NM_001081322.11  NP_001074791.11 
     752320145 
    chicken
    (Gallus gallus)
    Aves MYO5C1 myosin VC 75.67(n)
    80.25(a)
      430027  XM_003641843.2  XP_003641891.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYO5C6
    myosin VC
    78(a)
    1 ↔ 1
    GL343479.1(58955-91743)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.129372 Transcribed sequence with moderate similarity to protein more 76.59(n)    BX721377.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myo5c1 myosin VC 65.69(n)
    64.73(a)
      562676  XM_686051.4  XP_691143.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta didum3 myosin ATPase 37(a)
    (best of 2)
      2 43D3   --
    worm
    (Caenorhabditis elegans)
    Secernentea hum-23   -- 34(a)   V(9388744-9402300)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SGM1(YJR134C)4 Protein of unknown function, required for wild-type more   --   10(675852-673729) 853598  NP_012668.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons XID1 XID 47.42(n)
    39(a)
      817886  NM_128883.2  NP_180882.2 
    rice
    (Oryza sativa)
    Liliopsida NM_196325.12   -- 75.81(n)    NM_196325.1 


    ENSEMBL Gene Tree for MYO5C (if available)
    TreeFam Gene Tree for MYO5C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYO5C gene
    MYO3A2  MYO9A2  MYO102  MYO7A2  MYO162  MYO9B2  MYO5A2  MYO7B2  
    PLEKHH32  MYO5B2  MYO62  MYO3B2  
    Selected SIMAP similar genes for MYO5C using alignment to 6 protein entries:     MYO5C_HUMAN (see all proteins) (see all similar genes):
    MYO5A    MYO5B    MYO1B    MYO9A    MYO1A    MYO9B
    MYO1G    MYH11    MYO1C    MYO1D    MYH10    MYO1F variant protein
    MYO1E    MYO6    MYO10    MYH2    MYO9B variant protein    MYO7A

    Find genes that share paralogs with MYO5C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYO5C (see all 2024)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1158884881,2
    F--52498595(+) ATGTGT/CCTTCC 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1135511471,2
    F--52498778(+) TTCCTG/AACCCA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1850013161,2
    --52498825(+) GAGAAA/GGTGGC 1 -- int10--------
    rs1437488451,2
    --52498842(+) CAAGCA/CAGGAA 1 -- int10--------
    rs734048551,2
    C,F--52498877(+) ATGCTG/AGCACC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1905009851,2
    --52499012(+) GAGACG/TAAAGA 1 -- int10--------
    rs1489186991,2
    --52499089(+) CTTTGC/TGAGGC 1 -- int10--------
    rs1436577951,2
    --52499158(+) AACCCC/TATCTC 1 -- int10--------
    rs1808986291,2
    --52499187(+) TAACCA/GGGCAT 1 -- int10--------
    rs1510027091,2
    C--52499198(+) GGTGGC/TGCATG 1 -- int10--------

    HapMap Linkage Disequilibrium report for MYO5C (52484515 - 52587995 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for MYO5C:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2637818CNV Deletion19546169
    esv1288276CNV Deletion17803354
    esv2749694CNV Deletion23290073
    esv2403082CNV Deletion18987734
    esv999998CNV Deletion20482838
    nsv1537CNV Loss18451855
    nsv904220CNV Loss21882294
    esv7451CNV Loss19470904
    nsv833005CNV Gain17160897
    nsv471244CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYO5C
    DNA2.0 Custom Variant and Variant Library Synthesis for MYO5C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610022    OMIM disorders: --


    Find genes that share disorders with MYO5C           About GenesLikeMe

    Genetic Association Database (GAD): MYO5C
    Human Genome Epidemiology (HuGE) Navigator: MYO5C (1 document)

    Export disorders for MYO5C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYO5C gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with MYO5C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human myosin-Vc is a novel class V myosin expressed in epithelial cells. (PubMed id 11870218)1, 2, 3, 9 Rodriguez O.C. and Cheney R.E. (J. Cell Sci. 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Human myosin Vc is a low duty ratio, nonprocessive molecular motor. (PubMed id 18201966)1, 9 Takagi Y....KovA!cs M. (J. Biol. Chem. 2008)
    4. Human myosin Vc is a low duty ratio nonprocessive motor. (PubMed id 18079121)1, 9 Watanabe S....Ikebe M. (J. Biol. Chem. 2008)
    5. Myosin Vc is a molecular motor that functions in secretory granule trafficking. (PubMed id 19741097)1, 9 Jacobs D.T....Cheney R.E. (Mol. Biol. Cell 2009)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. Structural insights into functional overlapping and differentiation among myosin V motors. (PubMed id 24097982)1 Nascimento A.F....Murakami M.T. (J. Biol. Chem. 2013)
    8. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55930 HGNC: 7604 AceView: MYO5C Ensembl:ENSG00000128833 euGenes: HUgn55930
    ECgene: MYO5C H-InvDB: MYO5C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYO5C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYO5C gene:
    Search GeneIP for patents involving MYO5C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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