Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MYO3B Gene

Aliases for MYO3B Gene

  • Myosin IIIB 2 3
  • EC 4 63
  • Myosin-IIIb 3
  • EC 2.7.11 63

External Ids for MYO3B Gene

Previous GeneCards Identifiers for MYO3B Gene

  • GC02P169086
  • GC02P169576
  • GC02P170998
  • GC02P171237
  • GC02P170860
  • GC02P170742
  • GC02P162921
  • GC02P171034

Summaries for MYO3B Gene

Entrez Gene Summary for MYO3B Gene

  • This gene encodes one of the class III myosins. Myosins are ATPases, activated by actin, that move along actin filaments in the cell. This class of myosins are characterized by an amino-terminal kinase domain and shown to be present in photoreceptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

GeneCards Summary for MYO3B Gene

MYO3B (Myosin IIIB) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and ERK Signaling. GO annotations related to this gene include protein serine/threonine kinase activity and microfilament motor activity. An important paralog of this gene is MYO7A.

UniProtKB/Swiss-Prot for MYO3B Gene

  • Probable actin-based motor with a protein kinase activity

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO3B Gene

Genomics for MYO3B Gene

Regulatory Elements for MYO3B Gene

Genomic Location for MYO3B Gene

170,178,145 bp from pter
170,655,171 bp from pter
477,027 bases
Plus strand

Genomic View for MYO3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYO3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO3B Gene

Proteins for MYO3B Gene

  • Protein details for MYO3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B8ZZR2
    • Q53QE1
    • Q53T08
    • Q8IX64
    • Q8IX65
    • Q8IX66
    • Q8IX67
    • Q8IX68
    • Q96N94

    Protein attributes for MYO3B Gene

    1341 amino acids
    Molecular mass:
    151829 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MYO3B Gene

neXtProt entry for MYO3B Gene

Proteomics data for MYO3B Gene at MOPED

Selected DME Specific Peptides for MYO3B Gene

Post-translational modifications for MYO3B Gene

  • Ubiquitination at Lys908
  • Modification sites at PhosphoSitePlus

Other Protein References for MYO3B Gene

Domains for MYO3B Gene

Gene Families for MYO3B Gene

  • MYOIII :Myosins / Myosin superfamily : Class III

Suggested Antigen Peptide Sequences for MYO3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8WXR4
  • Contains 2 IQ domains.
  • Contains 1 myosin motor domain.
  • Contains 1 protein kinase domain.
  • In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
  • In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MYO3B: view

Function for MYO3B Gene

Molecular function for MYO3B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function:
Probable actin-based motor with a protein kinase activity

Enzyme Numbers (IUBMB) for MYO3B Gene

Gene Ontology (GO) - Molecular Function for MYO3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000146 microfilament motor activity IEA --
GO:0003774 motor activity --
GO:0003779 actin binding IEA --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
genes like me logo Genes that share ontologies with MYO3B: view
genes like me logo Genes that share phenotypes with MYO3B: view

Animal Model Products

miRNA for MYO3B Gene

miRTarBase miRNAs that target MYO3B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYO3B

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MYO3B Gene

Localization for MYO3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO3B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for MYO3B Gene COMPARTMENTS Subcellular localization image for MYO3B gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for MYO3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001750 photoreceptor outer segment IEA --
GO:0001917 photoreceptor inner segment IEA --
GO:0005737 cytoplasm IEA --
GO:0016459 myosin complex IEA --
GO:0032426 stereocilium bundle tip IEA --
genes like me logo Genes that share ontologies with MYO3B: view

Pathways for MYO3B Gene

genes like me logo Genes that share pathways with MYO3B: view

Pathways by source for MYO3B Gene

Gene Ontology (GO) - Biological Process for MYO3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0007601 visual perception IEA --
GO:0018105 peptidyl-serine phosphorylation IEA --
GO:0018107 peptidyl-threonine phosphorylation IEA --
GO:0046777 protein autophosphorylation IEA --
genes like me logo Genes that share ontologies with MYO3B: view

Compounds for MYO3B Gene

(2) HMDB Compounds for MYO3B Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
genes like me logo Genes that share compounds with MYO3B: view

Transcripts for MYO3B Gene

Unigene Clusters for MYO3B Gene

Myosin IIIB:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYO3B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO3B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^
SP1: - - -
SP2: -

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30

Relevant External Links for MYO3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYO3B Gene

mRNA expression in normal human tissues for MYO3B Gene

mRNA differential expression in normal tissues according to GTEx for MYO3B Gene

This gene is overexpressed in Kidney - Cortex (6.6), Testis (4.6), and Artery - Tibial (4.4).

Protein differential expression in normal tissues for MYO3B Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYO3B Gene

SOURCE GeneReport for Unigene cluster for MYO3B Gene Hs.671900

mRNA Expression by UniProt/SwissProt for MYO3B Gene

Tissue specificity: Expressed in retina, kidney and testis
genes like me logo Genes that share expressions with MYO3B: view

Expression partners for MYO3B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MYO3B Gene

Orthologs for MYO3B Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO3B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC536123 35
  • 91.08 (n)
  • 91.79 (a)
MYO3B 36
  • 94 (a)
(Canis familiaris)
Mammalia MYO3B 35
  • 91.91 (n)
  • 91.65 (a)
MYO3B 36
  • 94 (a)
(Mus musculus)
Mammalia Myo3b 35
  • 84.71 (n)
  • 87.46 (a)
Myo3b 16
Myo3b 36
  • 86 (a)
(Pan troglodytes)
Mammalia MYO3B 35
  • 99.33 (n)
  • 98.96 (a)
MYO3B 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Myo3b 35
  • 84.64 (n)
  • 87.9 (a)
(Monodelphis domestica)
Mammalia MYO3B 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia MYO3B 36
  • 86 (a)
(Gallus gallus)
Aves MYO3B 35
  • 76.92 (n)
  • 80.65 (a)
MYO3B 36
  • 79 (a)
(Anolis carolinensis)
Reptilia MYO3B 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia myo3b 35
  • 73.59 (n)
  • 78.91 (a)
(Danio rerio)
Actinopterygii myo3b 35
  • 69.44 (n)
  • 74.58 (a)
myo3b 36
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta ninaC 37
  • 32 (a)
Species with no ortholog for MYO3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO3B Gene

Gene Tree for MYO3B (if available)
Gene Tree for MYO3B (if available)

Paralogs for MYO3B Gene

Paralogs for MYO3B Gene

genes like me logo Genes that share paralogs with MYO3B: view

Variants for MYO3B Gene

Sequence variations from dbSNP and Humsavar for MYO3B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs17083 -- 170,362,666(-) TGAAA(C/T)AGGTA intron-variant
rs716427 -- 170,319,334(-) CAGCC(C/T)AAAAT intron-variant
rs717542 -- 170,611,979(-) AGGAT(A/G)CTACA intron-variant
rs717543 -- 170,612,210(-) CCTGT(A/G)AAATG intron-variant
rs724529 -- 170,629,264(-) AATCA(A/G)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO3B Gene

Variant ID Type Subtype PubMed ID
nsv3027 CNV Loss 18451855
nsv516684 CNV Loss 19592680
nsv433288 CNV Loss 18776910
esv2627207 CNV Deletion 19546169
nsv875408 CNV Gain 21882294
nsv3028 CNV Loss 18451855
nsv525740 CNV Loss 19592680
nsv834455 CNV Gain 17160897
nsv483086 CNV Gain 15286789
nsv3029 CNV Loss 18451855

Relevant External Links for MYO3B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO3B Gene

Disorders for MYO3B Gene

(1) University of Copenhagen DISEASES for MYO3B Gene

Relevant External Links for MYO3B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MYO3B: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for MYO3B Gene

Publications for MYO3B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. A class III myosin expressed in the retina is a potential candidate for Bardet-Biedl syndrome. (PMID: 11991710) Dose A.C. … Burnside B. (Genomics 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. (PMID: 20200978) Ichikawa S. … Econs M.J. (J. Bone Miner. Res. 2010) 3

Products for MYO3B Gene

Sources for MYO3B Gene

Back to Top