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Aliases for MYO3B Gene

Aliases for MYO3B Gene

  • Myosin IIIB 2 3 5
  • EC 2.7.11.1 4 61
  • Myosin-IIIb 3
  • EC 2.7.11 61

External Ids for MYO3B Gene

Previous GeneCards Identifiers for MYO3B Gene

  • GC02P169086
  • GC02P169576
  • GC02P170998
  • GC02P171237
  • GC02P170860
  • GC02P170742
  • GC02P162921
  • GC02P171034

Summaries for MYO3B Gene

Entrez Gene Summary for MYO3B Gene

  • This gene encodes one of the class III myosins. Myosins are ATPases, activated by actin, that move along actin filaments in the cell. This class of myosins are characterized by an amino-terminal kinase domain and shown to be present in photoreceptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

GeneCards Summary for MYO3B Gene

MYO3B (Myosin IIIB) is a Protein Coding gene. Diseases associated with MYO3B include Entropion and Deafness, Autosomal Recessive 30. Among its related pathways are PAK Pathway and Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MYO3A.

UniProtKB/Swiss-Prot for MYO3B Gene

  • Probable actin-based motor with a protein kinase activity.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO3B Gene

Genomics for MYO3B Gene

Regulatory Elements for MYO3B Gene

Enhancers for MYO3B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G170154 1.4 Ensembl ENCODE dbSUPER 18.2 -22.3 -22317 2.2 HDGF ATF1 FEZF1 TCF12 GATA2 CBX5 FOS NCOA1 JUNB REST MYO3B GC02P170173 RNU6-1006P
GH02G170141 0.9 FANTOM5 20.2 -36.2 -36230 0.6 PKNOX1 USF1 MXI1 MAX EBF1 GATA2 POLR2A EED IKZF2 CREM MYO3B RNU6-1006P GC02P170173
GH02G170157 1.2 ENCODE dbSUPER 12 -20.9 -20920 0.2 ELF3 FOXA2 MLX BMI1 RAD21 THRB RARA FOS CREM THAP11 MYO3B GC02P170173 RNU6-1006P
GH02G170220 1.2 Ensembl ENCODE dbSUPER 11.5 +43.8 43762 2.4 CTCF SCRT1 ZNF362 ZNF133 TEAD2 ZNF394 ATF2 RELA OSR2 ZNF121 MYO3B ENSG00000239467 GC02M170224 GC02P170204
GH02G170147 0.6 ENCODE 20.2 -30.3 -30278 1.6 SOX13 CTCF RAD21 ZBTB40 FOSL1 JUND FOS FOSL2 MYO3B GC02P170173 RNU6-1006P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYO3B on UCSC Golden Path with GeneCards custom track

Genomic Location for MYO3B Gene

Chromosome:
2
Start:
170,178,145 bp from pter
End:
170,655,171 bp from pter
Size:
477,027 bases
Orientation:
Plus strand

Genomic View for MYO3B Gene

Genes around MYO3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO3B Gene

Proteins for MYO3B Gene

  • Protein details for MYO3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXR4-MYO3B_HUMAN
    Recommended name:
    Myosin-IIIb
    Protein Accession:
    Q8WXR4
    Secondary Accessions:
    • B8ZZR2
    • Q53QE1
    • Q53T08
    • Q8IX64
    • Q8IX65
    • Q8IX66
    • Q8IX67
    • Q8IX68
    • Q96N94

    Protein attributes for MYO3B Gene

    Size:
    1341 amino acids
    Molecular mass:
    151829 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MYO3B Gene

neXtProt entry for MYO3B Gene

Selected DME Specific Peptides for MYO3B Gene

Q8WXR4:
  • GTPFWMAP
  • NSFEQLCINIANEQIQYY
  • GITAIEL
  • WMAPEVI
  • VKLVDFGVSAQL

Post-translational modifications for MYO3B Gene

  • Ubiquitination at Lys908
  • Modification sites at PhosphoSitePlus

Domains & Families for MYO3B Gene

Gene Families for MYO3B Gene

Suggested Antigen Peptide Sequences for MYO3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXR4

UniProtKB/Swiss-Prot:

MYO3B_HUMAN :
  • In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Family:
  • In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
  • In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MYO3B: view

Function for MYO3B Gene

Molecular function for MYO3B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Probable actin-based motor with a protein kinase activity.

Enzyme Numbers (IUBMB) for MYO3B Gene

Gene Ontology (GO) - Molecular Function for MYO3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYO3B: view
genes like me logo Genes that share phenotypes with MYO3B: view

Animal Models for MYO3B Gene

MGI Knock Outs for MYO3B:

Animal Model Products

  • Taconic Biosciences Mouse Models for MYO3B

miRNA for MYO3B Gene

miRTarBase miRNAs that target MYO3B

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYO3B

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYO3B Gene

Localization for MYO3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO3B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYO3B gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for MYO3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0016459 myosin complex IEA --
genes like me logo Genes that share ontologies with MYO3B: view

Pathways & Interactions for MYO3B Gene

genes like me logo Genes that share pathways with MYO3B: view

Gene Ontology (GO) - Biological Process for MYO3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007601 visual perception IEA --
GO:0016310 phosphorylation IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with MYO3B: view

No data available for SIGNOR curated interactions for MYO3B Gene

Drugs & Compounds for MYO3B Gene

(1) Drugs for MYO3B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for MYO3B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MYO3B: view

Transcripts for MYO3B Gene

Unigene Clusters for MYO3B Gene

Myosin IIIB:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYO3B

Alternative Splicing Database (ASD) splice patterns (SP) for MYO3B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^
SP1: - - -
SP2: -
SP3:

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1:
SP2:
SP3:

Relevant External Links for MYO3B Gene

GeneLoc Exon Structure for
MYO3B
ECgene alternative splicing isoforms for
MYO3B

Expression for MYO3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYO3B Gene

mRNA differential expression in normal tissues according to GTEx for MYO3B Gene

This gene is overexpressed in Kidney - Cortex (x6.6), Testis (x4.6), and Artery - Tibial (x4.4).

Protein differential expression in normal tissues from HIPED for MYO3B Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYO3B Gene



Protein tissue co-expression partners for MYO3B Gene

NURSA nuclear receptor signaling pathways regulating expression of MYO3B Gene:

MYO3B

SOURCE GeneReport for Unigene cluster for MYO3B Gene:

Hs.671900

mRNA Expression by UniProt/SwissProt for MYO3B Gene:

Q8WXR4-MYO3B_HUMAN
Tissue specificity: Expressed in retina, kidney and testis.

Evidence on tissue expression from TISSUES for MYO3B Gene

  • Kidney(4.3)
genes like me logo Genes that share expression patterns with MYO3B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYO3B Gene

Orthologs for MYO3B Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO3B 34 35
  • 99.33 (n)
cow
(Bos Taurus)
Mammalia MYO3B 35
  • 94 (a)
OneToOne
LOC536123 34
  • 91.08 (n)
dog
(Canis familiaris)
Mammalia MYO3B 34 35
  • 91.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYO3B 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo3b 34 16 35
  • 84.71 (n)
rat
(Rattus norvegicus)
Mammalia Myo3b 34
  • 84.64 (n)
oppossum
(Monodelphis domestica)
Mammalia MYO3B 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYO3B 34 35
  • 76.92 (n)
lizard
(Anolis carolinensis)
Reptilia MYO3B 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo3b 34
  • 73.59 (n)
zebrafish
(Danio rerio)
Actinopterygii myo3b 34 35
  • 69.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta ninaC 36
  • 32 (a)
Species where no ortholog for MYO3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO3B Gene

ENSEMBL:
Gene Tree for MYO3B (if available)
TreeFam:
Gene Tree for MYO3B (if available)

Paralogs for MYO3B Gene

Variants for MYO3B Gene

Sequence variations from dbSNP and Humsavar for MYO3B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000004092 -- 170,317,727(+) CTTAC(C/T)ATAGG intron-variant
rs1000004576 -- 170,620,909(+) TTTTA(C/G)TTGGA intron-variant
rs1000010391 -- 170,571,385(+) TGGGG(C/T)TAGCA intron-variant
rs1000011657 -- 170,250,600(+) CTTAA(A/G)TGTTA intron-variant, upstream-variant-2KB
rs1000017227 -- 170,530,871(+) AGTAT(A/G)TTAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO3B Gene

Variant ID Type Subtype PubMed ID
dgv2092n106 CNV deletion 24896259
esv2627207 CNV deletion 19546169
esv3374759 CNV insertion 20981092
esv3560522 CNV deletion 23714750
esv3560523 CNV deletion 23714750
esv3584962 CNV gain 24956385
esv3593336 CNV loss 21293372
esv3593338 CNV loss 21293372
nsv1006657 CNV gain 25217958
nsv1071634 CNV deletion 25765185
nsv1114149 CNV deletion 24896259
nsv1131526 CNV deletion 24896259
nsv1160883 CNV deletion 26073780
nsv3027 CNV deletion 18451855
nsv3028 CNV deletion 18451855
nsv3029 CNV deletion 18451855
nsv433288 CNV loss 18776910
nsv476032 CNV novel sequence insertion 20440878
nsv483086 CNV gain 15286789
nsv516684 CNV loss 19592680
nsv525740 CNV loss 19592680
nsv834455 CNV gain 17160897
nsv961529 CNV duplication 23825009

Variation tolerance for MYO3B Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.73; 95.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO3B Gene

Human Gene Mutation Database (HGMD)
MYO3B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYO3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO3B Gene

Disorders for MYO3B Gene

MalaCards: The human disease database

(2) MalaCards diseases for MYO3B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
entropion
deafness, autosomal recessive 30
  • autosomal recessive nonsyndromic deafness 30
- elite association - COSMIC cancer census association via MalaCards
Search MYO3B in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYO3B

Genetic Association Database (GAD)
MYO3B
Human Genome Epidemiology (HuGE) Navigator
MYO3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO3B
genes like me logo Genes that share disorders with MYO3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYO3B Gene

Publications for MYO3B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. A class III myosin expressed in the retina is a potential candidate for Bardet-Biedl syndrome. (PMID: 11991710) Dose A.C. … Burnside B. (Genomics 2002) 3 4 64
  5. Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin. (PMID: 26785147) Liu H. … Zhang M. (Elife 2016) 3 64

Products for MYO3B Gene

  • Addgene plasmids for MYO3B

Sources for MYO3B Gene

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