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Aliases for MYO3B Gene

Aliases for MYO3B Gene

  • Myosin IIIB 2 3 5
  • EC 2.7.11.1 4 63
  • EC 2.7.11 63

External Ids for MYO3B Gene

Previous GeneCards Identifiers for MYO3B Gene

  • GC02P169086
  • GC02P169576
  • GC02P170998
  • GC02P171237
  • GC02P170860
  • GC02P170742
  • GC02P162921
  • GC02P171034

Summaries for MYO3B Gene

Entrez Gene Summary for MYO3B Gene

  • This gene encodes one of the class III myosins. Myosins are ATPases, activated by actin, that move along actin filaments in the cell. This class of myosins are characterized by an amino-terminal kinase domain and shown to be present in photoreceptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

GeneCards Summary for MYO3B Gene

MYO3B (Myosin IIIB) is a Protein Coding gene. Diseases associated with MYO3B include Bardet-Biedl Syndrome. Among its related pathways are ERK Signaling and PAK Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MYO1D.

UniProtKB/Swiss-Prot for MYO3B Gene

  • Probable actin-based motor with a protein kinase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO3B Gene

Genomics for MYO3B Gene

Regulatory Elements for MYO3B Gene

Enhancers for MYO3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MYO3B on UCSC Golden Path with GeneCards custom track

Genomic Location for MYO3B Gene

Chromosome:
2
Start:
170,178,145 bp from pter
End:
170,655,171 bp from pter
Size:
477,027 bases
Orientation:
Plus strand

Genomic View for MYO3B Gene

Genes around MYO3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO3B Gene

Proteins for MYO3B Gene

  • Protein details for MYO3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXR4-MYO3B_HUMAN
    Recommended name:
    Myosin-IIIb
    Protein Accession:
    Q8WXR4
    Secondary Accessions:
    • B8ZZR2
    • Q53QE1
    • Q53T08
    • Q8IX64
    • Q8IX65
    • Q8IX66
    • Q8IX67
    • Q8IX68
    • Q96N94

    Protein attributes for MYO3B Gene

    Size:
    1341 amino acids
    Molecular mass:
    151829 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MYO3B Gene

neXtProt entry for MYO3B Gene

Proteomics data for MYO3B Gene at MOPED

Selected DME Specific Peptides for MYO3B Gene

Post-translational modifications for MYO3B Gene

  • Ubiquitination at Lys 908
  • Modification sites at PhosphoSitePlus

Other Protein References for MYO3B Gene

Domains & Families for MYO3B Gene

Gene Families for MYO3B Gene

Suggested Antigen Peptide Sequences for MYO3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXR4

UniProtKB/Swiss-Prot:

MYO3B_HUMAN :
  • Contains 2 IQ domains.
  • In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • Contains 2 IQ domains.
  • Contains 1 myosin motor domain.
  • Contains 1 protein kinase domain.
Family:
  • In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
  • In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MYO3B: view

Function for MYO3B Gene

Molecular function for MYO3B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Probable actin-based motor with a protein kinase activity.

Enzyme Numbers (IUBMB) for MYO3B Gene

Gene Ontology (GO) - Molecular Function for MYO3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYO3B: view
genes like me logo Genes that share phenotypes with MYO3B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MYO3B

miRNA for MYO3B Gene

miRTarBase miRNAs that target MYO3B

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYO3B Gene

Localization for MYO3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO3B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO3B Gene COMPARTMENTS Subcellular localization image for MYO3B gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MYO3B Gene

Pathways & Interactions for MYO3B Gene

genes like me logo Genes that share pathways with MYO3B: view

Gene Ontology (GO) - Biological Process for MYO3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with MYO3B: view

No data available for SIGNOR curated interactions for MYO3B Gene

Drugs & Compounds for MYO3B Gene

(1) Drugs for MYO3B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for MYO3B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MYO3B: view

Transcripts for MYO3B Gene

Unigene Clusters for MYO3B Gene

Myosin IIIB:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYO3B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^
SP1: - - -
SP2: -
SP3:

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1:
SP2:
SP3:

Relevant External Links for MYO3B Gene

GeneLoc Exon Structure for
MYO3B
ECgene alternative splicing isoforms for
MYO3B

Expression for MYO3B Gene

mRNA expression in normal human tissues for MYO3B Gene

mRNA differential expression in normal tissues according to GTEx for MYO3B Gene

This gene is overexpressed in Kidney - Cortex (x6.6), Testis (x4.6), and Artery - Tibial (x4.4).

Protein differential expression in normal tissues from HIPED for MYO3B Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYO3B Gene



SOURCE GeneReport for Unigene cluster for MYO3B Gene Hs.671900

mRNA Expression by UniProt/SwissProt for MYO3B Gene

Q8WXR4-MYO3B_HUMAN
Tissue specificity: Expressed in retina, kidney and testis.
genes like me logo Genes that share expression patterns with MYO3B: view

Protein tissue co-expression partners for MYO3B Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MYO3B Gene

Orthologs for MYO3B Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO3B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC536123 35
  • 91.08 (n)
  • 91.79 (a)
MYO3B 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO3B 35
  • 91.91 (n)
  • 91.65 (a)
MYO3B 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo3b 35
  • 84.71 (n)
  • 87.46 (a)
Myo3b 16
Myo3b 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYO3B 35
  • 99.33 (n)
  • 98.96 (a)
MYO3B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myo3b 35
  • 84.64 (n)
  • 87.9 (a)
oppossum
(Monodelphis domestica)
Mammalia MYO3B 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYO3B 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYO3B 35
  • 76.92 (n)
  • 80.65 (a)
MYO3B 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYO3B 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo3b 35
  • 73.59 (n)
  • 78.91 (a)
zebrafish
(Danio rerio)
Actinopterygii myo3b 35
  • 69.44 (n)
  • 74.58 (a)
myo3b 36
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ninaC 37
  • 32 (a)
Species with no ortholog for MYO3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO3B Gene

ENSEMBL:
Gene Tree for MYO3B (if available)
TreeFam:
Gene Tree for MYO3B (if available)

Paralogs for MYO3B Gene

Paralogs for MYO3B Gene

genes like me logo Genes that share paralogs with MYO3B: view

Variants for MYO3B Gene

Sequence variations from dbSNP and Humsavar for MYO3B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10209102 - 170,369,229(+) GTCTT(A/G)TTAAG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs4668246 - 170,369,331(+) TGGCC(A/G)AGGTT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs10168181 - 170,383,740(+) AACGC(A/G)CCTCC nc-transcript-variant, reference, missense
rs6736609 - 170,404,277(+) ATGCT(A/G)TACCC nc-transcript-variant, reference, missense
rs11892763 - 170,404,361(+) ATGAG(A/G)AAAGT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MYO3B Gene

Variant ID Type Subtype PubMed ID
nsv3027 CNV Loss 18451855
nsv516684 CNV Loss 19592680
nsv433288 CNV Loss 18776910
esv2627207 CNV Deletion 19546169
nsv875408 CNV Gain 21882294
nsv3028 CNV Loss 18451855
nsv525740 CNV Loss 19592680
nsv834455 CNV Gain 17160897
nsv483086 CNV Gain 15286789
nsv3029 CNV Loss 18451855

Variation tolerance for MYO3B Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.73; 95.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MYO3B Gene

Disorders for MYO3B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYO3B Gene - From: GeneCards

Disorder Aliases PubMed IDs
bardet-biedl syndrome
  • laurence-moon syndrome
- elite association - COSMIC cancer census association via MalaCards
Search MYO3B in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYO3B

Genetic Association Database (GAD)
MYO3B
Human Genome Epidemiology (HuGE) Navigator
MYO3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO3B
genes like me logo Genes that share disorders with MYO3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYO3B Gene

Publications for MYO3B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 3
  3. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  4. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PMID: 22623531) Toyoshima M. … Grandori C. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for MYO3B Gene

Sources for MYO3B Gene

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