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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYO3A Gene

protein-coding   GIFtS: 55
GCID: GC10P026263

myosin IIIA

(Previous names: deafness, autosomal recessive 30 )
(Previous symbol: DFNB30)
 Explore 8 diseases affiliated with
MYO3A via our new
 Human Malady Compendium 
Biological research products
for MYO3A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Myosin IIIA1 2
DFNB301 2 5
EC 2.7.11.13 8
Deafness, Autosomal Recessive 301
Myosin-IIIa1
EC 2.7.118

External Ids:    HGNC: 76011   Entrez Gene: 539042   Ensembl: ENSG000000957777   OMIM: 6068085   UniProtKB: Q8NEV43   

Export aliases for MYO3A gene to outside databases

Previous GC identifers: GC10P025958 GC10P026373 GC10P026227 GC10P025882


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYO3A:
The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are
categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on
their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal
to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays
an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein
have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the
strongest expression in retina and cochlea. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MYO3A_HUMAN, Q8NEV4
Function: Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing

Gene Wiki entry for MYO3A


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYO3A gene promoter:
         LHX3b/Lhx3b   HNF-1A   S8   FOXJ2 (long isoform)   HNF-1   HFH-1   LHX3a/Lhx3a   Msx-1   Pax-4a   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYO3A promoter sequence
   Search SABiosciences Chromatin IP Primers for MYO3A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYO3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.1   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p11.1

MYO3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO3A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P026263:  view genomic region     (about GC identifiers)

Start:
26,223,002 bp from pter      End:
26,501,465 bp from pter
Size:
278,464 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MYO3A_HUMAN, Q8NEV4 (See protein sequence)
Recommended Name: Myosin-IIIa  
Size: 1616 amino acids; 186208 Da
Subcellular location: Cytoplasm, cytoskeleton
Secondary accessions: Q5VZ28 Q8WX17 Q9NYS8

Explore the universe of human proteins at neXtProt for MYO3A: NX_Q8NEV4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NEV4

  • 4/6 DME Specific Peptides for MYO3A (Q8NEV4) (see all 6)
     GITAIEL  WMAPEVI  GTPFWMAP  LVLELCSGG 

    MYO3A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_059129.3  
    ENSEMBL proteins: 
     ENSP00000265944   ENSP00000365479   ENSP00000365478   ENSP00000445909  

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    Uscn Proteins for MYO3A

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001917photoreceptor inner segment IEA--
    GO:0005737cytoplasm IEA--
    GO:0016459myosin complex IEA--
    GO:0030175filopodium IDA17021180
    GO:0031941filamentous actin IDA12672820


    MYO3A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MYO3A


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MYO3A for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR000048 IQ_motif_EF-hand-BS
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8NEV4

    ProtoNet protein and cluster: Q8NEV4

    1 Blocks protein family: IPB000048 IQ calmodulin-binding region

    UniProtKB/Swiss-Prot: MYO3A_HUMAN, Q8NEV4
    Similarity: In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family
    Similarity: Contains 3 IQ domains
    Similarity: Contains 1 myosin head-like domain
    Similarity: Contains 1 protein kinase domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MYO3A_HUMAN, Q8NEV4
    Function: Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate MYO3A:
    hsa-miR-143
    SwitchGear 3'UTR luciferase reporter plasmidMYO3A 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000146microfilament motor activity IMP17021180
    GO:0003774motor activity ----
    GO:0003779actin binding ----
    GO:0004672protein kinase activity IDA12672820
    GO:0004674protein serine/threonine kinase activity IEA--


    MYO3A for ontologies           About GeneDecksing


    8 GenomeRNAi human phenotypes for MYO3A:
     Decreased CYP1A1 activity afte  Decreased mitotic index  Decreased substrate adherent c  High actin ratio cells 
     Increased HPV18 LCR reporter a  Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica  

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Myo3a):
     hearing/vestibular/ear  nervous system 

    MYO3A for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PAK Pathway
    PAK Pathway1.00
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    2Fc-GammaR-Mediated Phagocytosis in Macrophages
    Fc-GammaR-Mediated Phagocytosis in Macrophages1.00
    RhoGDI Pathway0.33
    3Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex1.00
    RhoA Pathway0.35
    4Sweet Taste Signaling
    Cellular Effects of Sildenafil0.46
    5Rho Family GTPases
    ILK Signaling0.45

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYO3A (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYO3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/50 Interacting proteins for MYO3A (Q8NEV43 ENSP000002659444) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GCOM1P0CAP13I2D: score=3 
    MYZAPP0CAP13I2D: score=3 
    TGFBR1P368973, ENSP000003641334I2D: score=3 STRING: ENSP00000364133
    POLR2MP0CAP23I2D: score=3 
    AXIN2Q9Y2T13I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007601visual perception IEA--
    GO:0007605sensory perception of sound IMP12032315
    GO:0018105peptidyl-serine phosphorylation IEA--
    GO:0018107peptidyl-threonine phosphorylation IEA--
    GO:0046777protein autophosphorylation IDA12672820


    MYO3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MYO3A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MYO3A

    2 HMDB Compounds for MYO3A    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    1 Novoseek chemical compound relationship for MYO3A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 38.5 7 20192276 (3), 17012748 (2)

    Search CenterWatch for drugs/clinical trials and news about MYO3A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYO3A gene: 
    NM_017433.4  

    Unigene Cluster for MYO3A:

    Myosin IIIA
    Hs.662630  [show with all ESTs]
    Unigene Representative Sequence: NM_017433
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265944(uc009xko.1 uc001isn.2 uc009xkp.1 uc009xkq.1)
    ENST00000376302(uc001ism.2) ENST00000376301 ENST00000477691 ENST00000478093
    ENST00000543632

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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYO3A
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    Additional cDNA sequence: 

    AF229172.1 AK310468.1 AK310494.1 AY101367.1 BC036079.1 BC045538.1 BC119811.1 

    5 DOTS entries:

    DT.92416991  DT.95186117  DT.102825991  DT.65285162  DT.65285711 

    24/45 AceView cDNA sequences (see all 45):

    AW196373 BQ636515 AW449678 BX108281 BX103331 AA460328 AA443280 AF229172 
    BC045538 AA476697 BI962761 BM128772 BC036079 AA460390 BF592767 CK903348 
    AI887923 NM_017433 AA903995 AY101367 BM129003 AW237052 BI789252 AW002980 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYO3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGTTTGGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MYO3A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYO3A

    SOURCE GeneReport for Unigene cluster: Hs.662630

    UniProtKB/Swiss-Prot: MYO3A_HUMAN, Q8NEV4
    Tissue specificity: Strongest expression in retina, retinal pigment epithelial cells, cochlea and pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO3A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MYO3A gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves MYO3A1 myosin IIIA 72(n)
    70.72(a)
      420494  XM_418597.3  XP_418597.3 
    lizard
    (Anolis carolinensis)
    Reptilia MYO3A6
    --
    68(a)
    1 ↔ 1
    6(14851108-14949604)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.125852 Danio rerio myosin IIIA (myo3a) mRNA, complete cds 73.43(n)    AF384863.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ninaC1 , 3 adaptation of rhodopsin mediated signaling
    protein more3
    neither inactivation nor afterpotential C1
    35(a)3
    45.36(n)1
    36.53(a)1
      27F33
    340121  NM_078779.21  NP_523503.21 


    ENSEMBL Gene Tree for MYO3A (if available)
    TreeFam Gene Tree for MYO3A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYO3A gene
    MYO9A2  MYO5C2  MYO102  MYO15A2  MYO7A2  MYO9B2  MYO162  MYO5A2  
    MYO7B2  MYO5B2  MYO62  MYO3B2  
    18/99 SIMAP similar genes for MYO3A using alignment to 6 protein entries:     MYO3A_HUMAN (see all proteins) (see all similar genes):
    MYO3B    MINK1    STK4/SLC36AL fusion    DKFZp686J1430    TNIK    MAP4K4
    STK25    MAP4K3    STK3    MYO1B    STK4    MAP4K5
    MST4    STK24    MYO10    TAOK3    NRK    MAP4K1

    MYO3A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5454 NCBI SNPs in MYO3A are shown (see all 5454    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs768717311,2
    --25881257(+) CCTCCC/TGAAAT 1 -- us2k10--------
    rs758984221,2
    F,--25881536(+) TCTTAG/TTTATT 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs70890231,2
    C,F,A,H,--25882598(+) GGGAAC/TTGGAC 1 -- us2k15Minor allele frequency- T:0.04NS EA WA 532
    rs798943481,2
    --25882624(+) ATTAGC/TCACTC 1 -- us2k10--------
    rs70730841,2
    C,F,--25883022(+) CCTCTA/GCAGGC 1 -- ut511Minor allele frequency- G:0.07NA 120
    rs70732241,2
    C,F,H,--25883105(+) AAGAAA/GTAAGG 1 -- ut514Minor allele frequency- G:0.06NS EA 382
    rs122658731,2
    C,F,--25883521(+) ACTTGA/GGGGAA 1 -- int12Minor allele frequency- G:0.09WA NA 238
    rs125700771,2
    H--25883794(+) GCGCCG/TAGTCT 1 -- int14Minor allele frequency- T:0.00NS EA 416
    rs122447691,2
    C,F,A,H,--25883830(+) GGCGCG/TCGCGG 1 -- int16Minor allele frequency- T:0.07NS EA NA 372
    rs110148651,2
    C,F,A,H,--25883913(+) CAGAAC/AAAGCA 1 -- int110Minor allele frequency- A:0.04NS EA NA WA 868

    HapMap Linkage Disequilibrium report for MYO3A (26223002 - 26473002 bp, first 250kb of MYO3A)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for MYO3A
         3 CNVs: 58435 65619 100899
         6 Indels: 75148 44726 39733 39732 42259 44727
    Human Gene Mutation Database (HGMD): MYO3A

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MYO3A for disorders           About GeneDecksing

    OMIM gene information: 606808   
    OMIM disorders: 607101  
    UniProtKB/Swiss-Prot: MYO3A_HUMAN, Q8NEV4
  • Defects in MYO3A are the cause of deafness autosomal recessive type 30 (DFNB30) [MIM:607101]. DFNB30 is a form
  • of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear,
    the nerve pathways to the brain, or the area of the brain that receives sound information

    8 diseases for MYO3A:    About MalaCards
    deafness, autosomal recessive 30    hearing loss    anxiety disorder    rheumatoid arthritis
    alzheimer's disease    arthritis    colorectal cancer    retinitis

    1 disease from the University of Copenhagen DISEASES database for MYO3A:
    Nonsyndromic deafness
    Human Genome Epidemiology (HuGE) Navigator: MYO3A (5 documents)

    Export disorders for MYO3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYO3A gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with MYO3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal localization of a human class III myosin. (PubMed id 10936054)1, 2, 3, 9 Dose A.C. and Burnside B. (2000)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    3. From flies' eyes to our ears: mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30. (PubMed id 12032315)1, 2 Walsh T.... Avraham K.B. (2002)
    4. The kinase domain alters the kinetic properties of the myosin IIIA motor. (PubMed id 18229949)1, 9 Dose A.C....Yengo C.M. (2008)
    5. Kinetic mechanism of human myosin IIIA. (PubMed id 17074769)1, 9 Dose A.C....Yengo C.M. (2007)
    6. Human myosin III is a motor having an extremely high affinity for actin. (PubMed id 17012748)1, 9 Kambara T....Ikebe M. (2006)
    7. A new compartment at stereocilia tips defined by spatial and temporal patterns of myosin IIIa expression. (PubMed id 17021180)1, 9 Schneider M.E....Kachar B. (2006)
    8. Intermolecular autophosphorylation regulates myosin I IIa activity and localization in parallel actin bundles. (PubMed id 20826793)1 Quintero O.A....Yengo C.M. (2010)
    9. Genome-wide association study for colorectal cancer i dentifies risk polymorphisms in German familial cases and implicates MAPK signa lling pathways in disease susceptibility. (PubMed id 20610541)1 Lascorz J....Hemminki K. (2010)
    10. Supervised machine learning and logistic regression i dentifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis. (PubMed id 20090771)1 Briggs F.B....Barcellos L.F. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 53904 HGNC: 7601 AceView: MYO3A Ensembl:ENSG00000095777 euGenes: HUgn53904
    ECgene: MYO3A H-InvDB: MYO3A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYO3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYO3A gene:
    Search GeneIP for patents involving MYO3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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