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MYO1H Gene

protein-coding   GIFtS: 43
GCID: GC12P109826

Myosin IH

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin IH1 2
myosin-1H2
myosin-Ih2
Unconventional Myosin-Ih2
Myosin-1H3

External Ids:    HGNC: 138791   Entrez Gene: 2834462   Ensembl: ENSG000001745277   OMIM: 6146365   UniProtKB: Q8N1T33   

Export aliases for MYO1H gene to outside databases

Previous GC identifers: GC12U990168 GC12P108362 GC12P106844


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYO1H Gene:
MYO1H (myosin IH) is a protein-coding gene. GO annotations related to this gene include motor activity and actin binding. An important paralog of this gene is MYO1D.

UniProtKB/Swiss-Prot: MYO1H_HUMAN, Q8N1T3
Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in
intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which
would be moved relative to actin filaments (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYO1H gene promoter:
         p53   LUN-1   LyF-1   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MYO1H

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYO1H


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.11   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.11

MYO1H Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO1H gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P109826:  view genomic region     (about GC identifiers)

Start:
109,785,708 bp from pter      End:
109,893,328 bp from pter
Size:
107,621 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MYO1H_HUMAN, Q8N1T3 (See protein sequence)
Recommended Name: Unconventional myosin-Ih  
Size: 1032 amino acids; 119037 Da
Caution: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1
(MYH1)
Secondary accessions: F5H3C6
Alternative splicing: 3 isoforms:  Q8N1T3-1   Q8N1T3-2   Q8N1T3-3   (May be due to intron retention)

Explore the universe of human proteins at neXtProt for MYO1H: NX_Q8N1T3

Explore proteomics data for MYO1H at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYO1H Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001094891.3  
    ENSEMBL proteins: 
     ENSP00000439182   ENSP00000474025   ENSP00000444076  

    MYO1H Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MYO1H

     
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    antibodies-online proteins for MYO1H (2 products) 

     
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    antibodies-online antibodies for MYO1H (2 products) 

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    antibodies-online kits for MYO1H (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MYOI: Myosins / Myosin superfamily : Class I

    4 InterPro protein domains:
     IPR010926 Myosin_tail_2
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS
     IPR001609 Myosin_head_motor_dom

    Graphical View of Domain Structure for InterPro Entry Q8N1T3

    ProtoNet protein and cluster: Q8N1T3

    UniProtKB/Swiss-Prot: MYO1H_HUMAN, Q8N1T3
    Similarity: Contains 2 IQ domains
    Similarity: Contains 1 myosin head-like domain


    Find genes that share domains with MYO1H           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYO1H_HUMAN, Q8N1T3
    Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in
    intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which
    would be moved relative to actin filaments (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with MYO1H           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MYO1H

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate MYO1H:
    hsa-miR-3927
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016459myosin complex IEA--

    Find genes that share ontologies with MYO1H           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYO1H About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    wtCFTR and delta508 traffic Clathrin coated vesicles formation norm and CF 0.35
    Transport Clathrin coated vesicle cycle0.66

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for MYO1H
        wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
    Transport Clathrin-coated vesicle cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYO1H
    Interactions:

        Search GeneGlobe Interaction Network for MYO1H

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYO1H



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYO1H gene (2 alternative transcripts): 
    NM_001101421.3  NM_173597.1  

    Unigene Cluster for MYO1H:

    Myosin IH
    Hs.512008  [show with all ESTs]
    Unigene Representative Sequence: NM_001101421
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310903(uc010sxn.1 uc010sxo.1) ENST00000542883 ENST00000542268
    ENST00000457826 ENST00000543960 ENST00000431443
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MYO1H using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MYO1H:
    hsa-miR-3927
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MYO1H
    Predesigned siRNA for gene silencing in human, mouse, rat MYO1H
    Clone
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYO1H
      QuantiTect SYBR Green Assays in human, mouse, rat MYO1H
      QuantiFast Probe-based Assays in human, mouse, rat MYO1H

    Additional mRNA sequence: AK298093.1 

    6 DOTS entries:

    DT.121210011  DT.121210013  DT.70104096  DT.103053  DT.105036  DT.100007967 

    7 AceView cDNA sequences:

    BU616423 AI985152 AK094906 NM_173597 AI656282 AI636948 AI652208 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYO1H expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTGAGACT
    MYO1H Expression
    About this image

    MYO1H Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYO1H Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512008
        Custom PCR Arrays for MYO1H
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MYO1H
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO1H

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYO1H gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myo1h1 , 5 myosin 1H1, 5 82.68(n)1
    87.87(a)1
      5 (55.99 cM)5
    2316461  NM_001164573.11  NP_001158045.11 
     1143149415 
    chicken
    (Gallus gallus)
    Aves MYO1H1 myosin IH 74.01(n)
    76.3(a)
      768372  XM_003642184.2  XP_003642232.2 
    lizard
    (Anolis carolinensis)
    Reptilia MYO1H6
    myosin IH
    72(a)
    1 ↔ 1
    AAWZ02038585(773-10905)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia myo1h1 myosin IH 67.87(n)
    70.71(a)
      100492763  XM_002932063.2  XP_002932109.2 
    zebrafish
    (Danio rerio)
    Actinopterygii myo1hb1 myosin IHb 65.36(n)
    66.83(a)
      796782  XM_001337131.4  XP_001337167.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Myo61F6
    Myosin 61F
    49(a)
    1 → many
    3L(1318480-1329617)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MYO36
    One of two type I myosins; localizes to actin cort...
    26(a)
    1 → many
    XI(196349-200167) YKL129C


    ENSEMBL Gene Tree for MYO1H (if available)
    TreeFam Gene Tree for MYO1H (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYO1H gene
    MYO1D2  MYO15A2  MYO1C2  MYO1A2  MYO1F2  MYO1G2  MYO1B2  MYO15B2  
    MYO1E2  MYO192  
    Selected SIMAP similar genes for MYO1H using alignment to 3 protein entries:     MYO1H_HUMAN (see all proteins) (see all similar genes):
    MYO1C    FLJ00395    MYO1F variant protein    MYO1E    MYO1A    MYO10
    MYO1F    MYO7A    MYO1D    MYO7B    MYO1B    MYO15A
    DKFZp686A01173    MYH6    MYH7    MYO5B    MYH3    MYH11

    Find genes that share paralogs with MYO1H           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYO1H (see all 1734)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs79654701,2
    C,F,H--109824537(+) ggataC/Aaaatt 1 -- us2k15Minor allele frequency- A:0.03NS EA WA 534
    rs1503104291,2
    --109824549(+) TTTGCA/GTCTGT 1 -- us2k10--------
    rs1379865641,2
    --109824675(+) TTATTC/TCTTCC 1 -- us2k10--------
    rs108501101,2
    C,F,A,H--109824726(+) AAGATG/AGTCCC 1 -- us2k117Minor allele frequency- A:0.13NS EA NA 2224
    rs73006001,2
    C,F--109824933(+) atctcC/Tctgtg 1 -- us2k11Minor allele frequency- T:0.25WA 118
    rs792707541,2
    C,F--109825142(+) AATTGA/GGACGC 1 -- us2k11Minor allele frequency- G:0.24WA 118
    rs1141422041,2
    F--109825268(+) ATCCAA/TATTCA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs760571301,2
    C,F--109825300(+) ATAACC/AAACTG 1 -- us2k11Minor allele frequency- A:0.25WA 118
    rs1826030181,2
    --109825308(+) CTGCAC/TGCTTT 1 -- us2k10--------
    rs761209831,2
    C,F--109825390(+) CAGGCC/GGCTTC 1 -- us2k11Minor allele frequency- G:0.25WA 118

    HapMap Linkage Disequilibrium report for MYO1H (109785708 - 109893328 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MYO1H:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv515873CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYO1H
    DNA2.0 Custom Variant and Variant Library Synthesis for MYO1H

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614636    OMIM disorders: --


    Find genes that share disorders with MYO1H           About GenesLikeMe

    Genetic Association Database (GAD): MYO1H

    Export disorders for MYO1H gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYO1H gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MYO1H)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PubMed id 20864672)1, 4 Waterworth D.M....Sandhu M.S. (Arterioscler. Thromb. Vasc. Biol. 2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Genetic variation in myosin 1H contributes to mandibular prognathism. (PubMed id 22196185)1 Tassopoulou-Fishell M....Vieira A.R. (Am J Orthod Dentofacial Orthop 2012)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    6. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 283446 HGNC: 13879 AceView: FLJ37587 Ensembl:ENSG00000174527 euGenes: HUgn283446
    ECgene: MYO1H H-InvDB: MYO1H

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYO1H Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYO1H gene:
    Search GeneIP for patents involving MYO1H

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     antibodies-online proteins for MYO1H (2 products)
           
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