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Aliases for MYO1H Gene

Aliases for MYO1H Gene

  • Myosin IH 2 3
  • Myosin-1H 3 4
  • Myosin-Ih 3

External Ids for MYO1H Gene

Previous GeneCards Identifiers for MYO1H Gene

  • GC12U990168
  • GC12P108362
  • GC12P109826
  • GC12P106844

Summaries for MYO1H Gene

GeneCards Summary for MYO1H Gene

MYO1H (Myosin IH) is a Protein Coding gene. Among its related pathways are wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF). GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYO1D.

UniProtKB/Swiss-Prot for MYO1H Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO1H Gene

Genomics for MYO1H Gene

Regulatory Elements for MYO1H Gene

Genomic Location for MYO1H Gene

Chromosome:
12
Start:
109,347,903 bp from pter
End:
109,455,523 bp from pter
Size:
107,621 bases
Orientation:
Plus strand

Genomic View for MYO1H Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYO1H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO1H Gene

Proteins for MYO1H Gene

  • Protein details for MYO1H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1T3-MYO1H_HUMAN
    Recommended name:
    Unconventional myosin-Ih
    Protein Accession:
    Q8N1T3
    Secondary Accessions:
    • F5H3C6

    Protein attributes for MYO1H Gene

    Size:
    1032 amino acids
    Molecular mass:
    119037 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MYO1H Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO1H Gene

Proteomics data for MYO1H Gene at MOPED

Post-translational modifications for MYO1H Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYO1H Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYO1H Gene

Domains & Families for MYO1H Gene

Gene Families for MYO1H Gene

Protein Domains for MYO1H Gene

Suggested Antigen Peptide Sequences for MYO1H Gene

Graphical View of Domain Structure for InterPro Entry

Q8N1T3

UniProtKB/Swiss-Prot:

MYO1H_HUMAN :
  • Contains 2 IQ domains.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • Contains 2 IQ domains.
  • Contains 1 myosin motor domain.
  • Contains 1 TH1 (class I myosin tail homology) domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO1H: view

Function for MYO1H Gene

Molecular function for MYO1H Gene

UniProtKB/Swiss-Prot Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).

Gene Ontology (GO) - Molecular Function for MYO1H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYO1H: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYO1H

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for MYO1H Gene

Localization for MYO1H Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO1H Gene COMPARTMENTS Subcellular localization image for MYO1H gene
Compartment Confidence
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for MYO1H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016459 myosin complex IEA --
genes like me logo Genes that share ontologies with MYO1H: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYO1H Gene

Pathways & Interactions for MYO1H Gene

genes like me logo Genes that share pathways with MYO1H: view

Pathways by source for MYO1H Gene

Interacting Proteins for MYO1H Gene

Gene Ontology (GO) - Biological Process for MYO1H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with MYO1H: view

No data available for SIGNOR curated interactions for MYO1H Gene

Drugs & Compounds for MYO1H Gene

No Compound Related Data Available

Transcripts for MYO1H Gene

mRNA/cDNA for MYO1H Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYO1H Gene

Myosin IH:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYO1H

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO1H Gene

No ASD Table

Relevant External Links for MYO1H Gene

GeneLoc Exon Structure for
MYO1H
ECgene alternative splicing isoforms for
MYO1H

Expression for MYO1H Gene

mRNA expression in normal human tissues for MYO1H Gene

mRNA differential expression in normal tissues according to GTEx for MYO1H Gene

This gene is overexpressed in Testis (x10.0).

Protein differential expression in normal tissues from HIPED for MYO1H Gene

This gene is overexpressed in Heart (58.5) and Adipocyte (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYO1H Gene



SOURCE GeneReport for Unigene cluster for MYO1H Gene Hs.512008

genes like me logo Genes that share expression patterns with MYO1H: view

Protein tissue co-expression partners for MYO1H Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MYO1H Gene

Orthologs for MYO1H Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYO1H Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYO1H 35
  • 89.09 (n)
  • 90.86 (a)
MYO1H 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO1H 35
  • 89.56 (n)
  • 92.07 (a)
MYO1H 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo1h 35
  • 82.68 (n)
  • 87.87 (a)
Myo1h 16
Myo1h 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYO1H 35
  • 99.45 (n)
  • 99.51 (a)
MYO1H 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYO1H 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYO1H 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYO1H 35
  • 74.01 (n)
  • 76.3 (a)
MYO1H 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYO1H 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo1h 35
  • 67.87 (n)
  • 70.71 (a)
zebrafish
(Danio rerio)
Actinopterygii myo1hb 35
  • 65.36 (n)
  • 66.83 (a)
myo1ha 36
  • 64 (a)
OneToMany
myo1hb 36
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Myo61F 36
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO3 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11244 36
  • 52 (a)
OneToMany
Species with no ortholog for MYO1H:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO1H Gene

ENSEMBL:
Gene Tree for MYO1H (if available)
TreeFam:
Gene Tree for MYO1H (if available)

Paralogs for MYO1H Gene

Paralogs for MYO1H Gene

genes like me logo Genes that share paralogs with MYO1H: view

Variants for MYO1H Gene

Sequence variations from dbSNP and Humsavar for MYO1H Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs759970 -- 109,388,370(-) GATGA(A/G)AAAAC upstream-variant-2KB, utr-variant-5-prime
rs759971 -- 109,388,241(-) TTTTT(A/T)AAATT upstream-variant-2KB
rs759972 -- 109,388,136(-) ACTTT(A/G)TAATT upstream-variant-2KB
rs888190 -- 109,447,569(-) TATAA(C/T)GAAAT utr-variant-3-prime
rs920224 -- 109,389,105(-) GAAAC(C/T)CTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO1H Gene

Variant ID Type Subtype PubMed ID
nsv515873 CNV Gain 19592680

Variation tolerance for MYO1H Gene

Residual Variation Intolerance Score: 82.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.35; 88.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO1H Gene

HapMap Linkage Disequilibrium report
MYO1H

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO1H Gene

Disorders for MYO1H Gene

Relevant External Links for MYO1H

Genetic Association Database (GAD)
MYO1H
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO1H
genes like me logo Genes that share disorders with MYO1H: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYO1H Gene

Publications for MYO1H Gene

  1. Genetic variation in myosin 1H contributes to mandibular prognathism. (PMID: 22196185) Tassopoulou-Fishell M. … Vieira A.R. (Am J Orthod Dentofacial Orthop 2012) 67
  2. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PMID: 20864672) Waterworth D.M. … Sandhu M.S. (Arterioscler. Thromb. Vasc. Biol. 2010) 67
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for MYO1H Gene

Sources for MYO1H Gene

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