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Aliases for MYO1G Gene

Aliases for MYO1G Gene

  • Myosin IG 2 3
  • Minor Histocompatibility Antigen HA-2 2 3
  • HLA-HA2 3 6
  • HA2 3 4
  • Unconventional Myosin-Ig 3
  • Myosin-Ig 3
  • D6S207E 6
  • MHAG 3

External Ids for MYO1G Gene

Summaries for MYO1G Gene

Entrez Gene Summary for MYO1G Gene

  • MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010]

GeneCards Summary for MYO1G Gene

MYO1G (Myosin IG) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and ERK Signaling. GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYO1D.

UniProtKB/Swiss-Prot for MYO1G Gene

  • Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis.

  • Minor histocompatibility antigen HA-2: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO1G Gene

Genomics for MYO1G Gene

Genomic Location for MYO1G Gene

Start:
44,962,661 bp from pter
End:
44,979,105 bp from pter
Size:
16,445 bases
Orientation:
Minus strand

Genomic View for MYO1G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYO1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO1G Gene

Regulatory Elements for MYO1G Gene

Proteins for MYO1G Gene

  • Protein details for MYO1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B0I1T2-MYO1G_HUMAN
    Recommended name:
    Unconventional myosin-Ig
    Protein Accession:
    B0I1T2
    Secondary Accessions:
    • Q8TEI9
    • Q8TES2
    • Q96BE2
    • Q96RI5
    • Q96RI6

    Protein attributes for MYO1G Gene

    Size:
    1018 amino acids
    Molecular mass:
    116442 Da
    Quaternary structure:
    • Interacts with calmodulin; via its IQ motifs.
    SequenceCaution:
    • Sequence=BAB84876.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for MYO1G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO1G Gene

Proteomics data for MYO1G Gene at MOPED

Post-translational modifications for MYO1G Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys87, Lys140, Lys164, Lys188, Lys214, Lys341, Lys357, Lys507, Lys518, Lys544, Lys571, Lys594, Lys690, Lys815, Lys863, and Lys898

Other Protein References for MYO1G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYO1G Gene

Domains for MYO1G Gene

Gene Families for MYO1G Gene

HGNC:
  • MYOI :Myosins / Myosin superfamily : Class I

Protein Domains for MYO1G Gene

UniProtKB/Swiss-Prot:

MYO1G_HUMAN
Domain:
  • The myosin tail domain mediates binding to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) and binds to membranous compartments. It is required for recruitment to Fc-gamma receptor (Fc-gamma-R) phagocytic cups.:
    • B0I1T2
  • Contains 1 IQ domain.:
    • B0I1T2
  • Contains 1 myosin motor domain.:
    • B0I1T2
  • Contains 1 myosin tail domain.:
    • B0I1T2
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.:
    • B0I1T2
genes like me logo Genes that share domains with MYO1G: view

Function for MYO1G Gene

Molecular function for MYO1G Gene

UniProtKB/Swiss-Prot Function: Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis.
UniProtKB/Swiss-Prot Function: Minor histocompatibility antigen HA-2: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201.

Gene Ontology (GO) - Molecular Function for MYO1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISS --
genes like me logo Genes that share ontologies with MYO1G: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MYO1G Gene

Localization for MYO1G Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO1G Gene

Cell membrane; Peripheral membrane protein. Cell projection, phagocytic cup. Note=Recruited to Fc-gamma receptor (Fc-gamma-R) phagocytic cup. In T-cells, transiently accumulates in discrete areas at the plasma membrane of migrating cells or when membranes are deformed (By similarity). Localization at the membrane is not highly dependent on phosphatidylinositol 4,5-bisphosphate levels. Released from the membrane in the presence of ATP. May be enriched in peripheral processes, such as microvilli or ruffles. {ECO:0000250 UniProtKB:Q5SUA5, ECO:0000269 PubMed:20071333}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO1G Gene COMPARTMENTS Subcellular localization image for MYO1G gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
cytosol 3
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MYO1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001891 phagocytic cup ISS --
GO:0005886 plasma membrane IDA 19968988
GO:0005902 microvillus IEA --
GO:0016020 membrane IDA 19946888
GO:0016459 myosin complex IEA --
genes like me logo Genes that share ontologies with MYO1G: view

Pathways for MYO1G Gene

genes like me logo Genes that share pathways with MYO1G: view

Pathways by source for MYO1G Gene

Gene Ontology (GO) - Biological Process for MYO1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002456 T cell mediated immunity ISS --
GO:0006887 exocytosis IEA --
GO:0006909 phagocytosis --
GO:0008152 metabolic process IEA --
GO:0031589 cell-substrate adhesion IEA --
genes like me logo Genes that share ontologies with MYO1G: view

Transcripts for MYO1G Gene

Unigene Clusters for MYO1G Gene

Myosin IG:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYO1G Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7: - -

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -

Relevant External Links for MYO1G Gene

GeneLoc Exon Structure for
MYO1G
ECgene alternative splicing isoforms for
MYO1G

Expression for MYO1G Gene

mRNA expression in normal human tissues for MYO1G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYO1G Gene

This gene is overexpressed in Whole Blood (21.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYO1G Gene

SOURCE GeneReport for Unigene cluster for MYO1G Gene Hs.37617

mRNA Expression by UniProt/SwissProt for MYO1G Gene

B0I1T2-MYO1G_HUMAN
Tissue specificity: Specifically expressed in hematopoietic cells.
genes like me logo Genes that share expressions with MYO1G: view

Orthologs for MYO1G Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYO1G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO1G 36
  • 99.51 (n)
  • 99.31 (a)
MYO1G 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYO1G 36
  • 88.45 (n)
  • 91.73 (a)
MYO1G 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO1G 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo1g 36
  • 86.23 (n)
  • 90.95 (a)
Myo1g 16
Myo1g 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYO1G 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 72 (a)
OneToMany
-- 37
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Myo1g 36
  • 85.57 (n)
  • 90.73 (a)
chicken
(Gallus gallus)
Aves MYO1G 36
  • 73.51 (n)
  • 70.32 (a)
MYO1G 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYO1G 37
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii MYO1G 37
  • 62 (a)
OneToOne
si:dkeyp-92c9.3 36
  • 63.39 (n)
  • 63.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta Myo31DF 37
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hum-5 37
  • 46 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO3 37
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 52 (a)
OneToMany
Species with no ortholog for MYO1G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MYO1G Gene

ENSEMBL:
Gene Tree for MYO1G (if available)
TreeFam:
Gene Tree for MYO1G (if available)

Paralogs for MYO1G Gene

Paralogs for MYO1G Gene

genes like me logo Genes that share paralogs with MYO1G: view

Variants for MYO1G Gene

Sequence variations from dbSNP and Humsavar for MYO1G Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
VAR_044013 -
VAR_044014 -
VAR_044015 -
VAR_050212 -

Structural Variations from Database of Genomic Variants (DGV) for MYO1G Gene

Variant ID Type Subtype PubMed ID
nsv830985 CNV Loss 17160897

Relevant External Links for MYO1G Gene

HapMap Linkage Disequilibrium report
MYO1G

Disorders for MYO1G Gene

(1) University of Copenhagen DISEASES for MYO1G Gene

Relevant External Links for MYO1G

Genetic Association Database (GAD)
MYO1G
Human Genome Epidemiology (HuGE) Navigator
MYO1G
genes like me logo Genes that share disorders with MYO1G: view

No data available for UniProtKB/Swiss-Prot for MYO1G Gene

Publications for MYO1G Gene

  1. Identification of a graft versus host disease-associated human minor histocompatibility antigen. (PMID: 7539551) den Haan J.M.M. … Goulmy E. (Science 1995) 3 4
  2. The HA-2 minor histocompatibility antigen is derived from a diallelic gene encoding a novel human class I myosin protein. (PMID: 11544309) Pierce R.A. … Engelhard V.H. (J. Immunol. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Myosin 1G (Myo1G) is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticity. (PMID: 19968988) Olety B. … BAohler M. (FEBS Lett. 2010) 3 4
  5. Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH). (PMID: 20071333) Patino-Lopez G. … Shaw S. (J. Biol. Chem. 2010) 3 4

Products for MYO1G Gene

Sources for MYO1G Gene

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