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Aliases for MYO1G Gene

Aliases for MYO1G Gene

  • Myosin IG 2 3 5
  • Minor Histocompatibility Antigen HA-2 2 3
  • HA2 3 4
  • Unconventional Myosin-Ig 3
  • Myosin-Ig 3
  • HLA-HA2 3
  • MHAG 3

External Ids for MYO1G Gene

Previous GeneCards Identifiers for MYO1G Gene

  • GC07M044648
  • GC07M044708
  • GC07M044743
  • GC07M044742
  • GC07M044775
  • GC07M044968
  • GC07M045003

Summaries for MYO1G Gene

Entrez Gene Summary for MYO1G Gene

  • MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010]

GeneCards Summary for MYO1G Gene

MYO1G (Myosin IG) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Delta508-CFTR traffic / ER-to-Golgi in CF. GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYO1D.

UniProtKB/Swiss-Prot for MYO1G Gene

  • Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis.

  • Minor histocompatibility antigen HA-2: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO1G Gene

Genomics for MYO1G Gene

Regulatory Elements for MYO1G Gene

Enhancers for MYO1G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F044975 1 FANTOM5 ENCODE 20.5 +0.2 183 6.5 HDGF PKNOX1 WRNIP1 SIN3A FEZF1 ZNF121 ZNF263 JUNB TBX21 PPARG CCM2 MYO1G ENSG00000260997 PURB RAMP3 SNHG15 OGDH ZMIZ2
GH07F044897 0.6 FANTOM5 16.3 +81.6 81594 0.3 MYO1G H2AFV LINC01952 ENSG00000228596 PURB OGDH PIR53562 LOC105375262
GH07F045035 1.2 Ensembl ENCODE 12.6 -57.6 -57554 1.5 SOX13 GATAD2A SCRT1 ELF3 SOX5 SAP130 SP5 FOXA3 ZSCAN9 KLF16 ENSG00000260997 NACAD MYO1G CCM2 ENSG00000228596 SNHG15 GC07M045025 GC07P045063
GH07F045032 0.8 Ensembl ENCODE 12.6 -54.5 -54495 1.6 CTCF ZNF263 MNT RAD21 ZNF316 MAFF ZFHX2 GATA3 POLR2A SMARCA4 CCM2 ENSG00000260997 MYO1G ENSG00000228596 SNHG15 GC07M045025 GC07P045063
GH07F045020 1.1 Ensembl ENCODE 12.3 -42.5 -42496 1.6 HDGF PKNOX1 ZBTB40 POLR2A EED CREM ZNF263 MTA2 TRIM22 JUNB CCM2 ENSG00000260997 MYO1G SNHG15 GC07M045025 LOC102723334
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MYO1G on UCSC Golden Path with GeneCards custom track

Promoters for MYO1G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001891658 805 1801 TBP PKNOX1 TBL1XR1 WRNIP1 SIN3A EGR1 RCOR1 ETV6 CREM EGR2

Genomic Location for MYO1G Gene

Chromosome:
7
Start:
44,962,661 bp from pter
End:
44,979,105 bp from pter
Size:
16,445 bases
Orientation:
Minus strand

Genomic View for MYO1G Gene

Genes around MYO1G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO1G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO1G Gene

Proteins for MYO1G Gene

  • Protein details for MYO1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B0I1T2-MYO1G_HUMAN
    Recommended name:
    Unconventional myosin-Ig
    Protein Accession:
    B0I1T2
    Secondary Accessions:
    • Q8TEI9
    • Q8TES2
    • Q96BE2
    • Q96RI5
    • Q96RI6

    Protein attributes for MYO1G Gene

    Size:
    1018 amino acids
    Molecular mass:
    116442 Da
    Quaternary structure:
    • Interacts with calmodulin; via its IQ motifs.
    SequenceCaution:
    • Sequence=BAB84876.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for MYO1G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO1G Gene

Post-translational modifications for MYO1G Gene

  • Ubiquitination at Lys 87, Lys 140, Lys 164, Lys 188, Lys 214, Lys 341, Lys 357, Lys 507, Lys 518, Lys 544, Lys 571, Lys 594, Lys 690, Lys 815, Lys 863, and Lys 898
  • Modification sites at PhosphoSitePlus

Other Protein References for MYO1G Gene

No data available for DME Specific Peptides for MYO1G Gene

Domains & Families for MYO1G Gene

Protein Domains for MYO1G Gene

Suggested Antigen Peptide Sequences for MYO1G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B0I1T2

UniProtKB/Swiss-Prot:

MYO1G_HUMAN :
  • The myosin tail domain mediates binding to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) and binds to membranous compartments. It is required for recruitment to Fc-gamma receptor (Fc-gamma-R) phagocytic cups.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • The myosin tail domain mediates binding to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) and binds to membranous compartments. It is required for recruitment to Fc-gamma receptor (Fc-gamma-R) phagocytic cups.
  • Contains 1 IQ domain.
  • Contains 1 myosin motor domain.
  • Contains 1 TH1 (class I myosin tail homology) domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO1G: view

Function for MYO1G Gene

Molecular function for MYO1G Gene

UniProtKB/Swiss-Prot Function:
Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis.
UniProtKB/Swiss-Prot Function:
Minor histocompatibility antigen HA-2: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201.

Gene Ontology (GO) - Molecular Function for MYO1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISS --
genes like me logo Genes that share ontologies with MYO1G: view
genes like me logo Genes that share phenotypes with MYO1G: view

Animal Models for MYO1G Gene

MGI Knock Outs for MYO1G:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MYO1G Gene

Localization for MYO1G Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO1G Gene

Cell membrane; Peripheral membrane protein. Cell projection, phagocytic cup. Note=Recruited to Fc-gamma receptor (Fc-gamma-R) phagocytic cup. In T-cells, transiently accumulates in discrete areas at the plasma membrane of migrating cells or when membranes are deformed (By similarity). Localization at the membrane is not highly dependent on phosphatidylinositol 4,5-bisphosphate levels. Released from the membrane in the presence of ATP. May be enriched in peripheral processes, such as microvilli or ruffles. {ECO:0000250 UniProtKB:Q5SUA5, ECO:0000269 PubMed:20071333}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO1G Gene COMPARTMENTS Subcellular localization image for MYO1G gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 3
cytosol 3
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MYO1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001891 phagocytic cup ISS --
GO:0005886 plasma membrane IEA,IDA 19968988
GO:0005902 microvillus IEA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016459 myosin complex IEA --
genes like me logo Genes that share ontologies with MYO1G: view

Pathways & Interactions for MYO1G Gene

genes like me logo Genes that share pathways with MYO1G: view

Gene Ontology (GO) - Biological Process for MYO1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002456 T cell mediated immunity ISS --
GO:0006887 exocytosis IEA --
GO:0006909 phagocytosis IEA --
genes like me logo Genes that share ontologies with MYO1G: view

No data available for SIGNOR curated interactions for MYO1G Gene

Transcripts for MYO1G Gene

Unigene Clusters for MYO1G Gene

Myosin IG:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO1G Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7: - -

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -

Relevant External Links for MYO1G Gene

GeneLoc Exon Structure for
MYO1G
ECgene alternative splicing isoforms for
MYO1G

Expression for MYO1G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYO1G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYO1G Gene

This gene is overexpressed in Whole Blood (x21.9).

Protein differential expression in normal tissues from HIPED for MYO1G Gene

This gene is overexpressed in Tlymphocyte (24.2), Peripheral blood mononuclear cells (13.7), and CD8 Tcells (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYO1G Gene



Protein tissue co-expression partners for MYO1G Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MYO1G Gene:

MYO1G

SOURCE GeneReport for Unigene cluster for MYO1G Gene:

Hs.37617

mRNA Expression by UniProt/SwissProt for MYO1G Gene:

B0I1T2-MYO1G_HUMAN
Tissue specificity: Specifically expressed in hematopoietic cells.
genes like me logo Genes that share expression patterns with MYO1G: view

Primer Products

Orthologs for MYO1G Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYO1G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO1G 34 35
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia MYO1G 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYO1G 34 35
  • 88.45 (n)
mouse
(Mus musculus)
Mammalia Myo1g 34 16 35
  • 86.23 (n)
rat
(Rattus norvegicus)
Mammalia Myo1g 34
  • 85.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 82 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MYO1G 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYO1G 34 35
  • 73.51 (n)
lizard
(Anolis carolinensis)
Reptilia MYO1G 35
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-92c9.3 34
  • 63.39 (n)
MYO1G 35
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Myo31DF 35
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hum-5 35
  • 46 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO3 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToMany
Species where no ortholog for MYO1G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MYO1G Gene

ENSEMBL:
Gene Tree for MYO1G (if available)
TreeFam:
Gene Tree for MYO1G (if available)

Paralogs for MYO1G Gene

Paralogs for MYO1G Gene

genes like me logo Genes that share paralogs with MYO1G: view

Variants for MYO1G Gene

Sequence variations from dbSNP and Humsavar for MYO1G Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10229130 -- 44,967,182(+) CTCCC(C/T)GACCC intron-variant
rs10230010 -- 44,963,863(+) ATGGG(A/G)CCTTT intron-variant
rs10253506 -- 44,968,907(+) TACCT(C/T)GATGT intron-variant
rs10257166 -- 44,978,701(+) GGGGC(C/T)GTGCT intron-variant
rs10262048 -- 44,974,288(+) CTGCC(C/T)GCTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO1G Gene

Variant ID Type Subtype PubMed ID
esv3369216 CNV duplication 20981092
nsv606828 CNV gain 21841781
nsv830985 CNV loss 17160897

Variation tolerance for MYO1G Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.67; 82.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO1G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYO1G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO1G Gene

Disorders for MYO1G Gene

Relevant External Links for MYO1G

Genetic Association Database (GAD)
MYO1G
Human Genome Epidemiology (HuGE) Navigator
MYO1G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO1G

No disorders were found for MYO1G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYO1G Gene

Publications for MYO1G Gene

  1. Myosin 1G (Myo1G) is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticity. (PMID: 19968988) Olety B. … BAohler M. (FEBS Lett. 2010) 3 4 64
  2. Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH). (PMID: 20071333) Patino-Lopez G. … Shaw S. (J. Biol. Chem. 2010) 3 4 64
  3. Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation. (PMID: 20353833) Larsen M.E. … Vindelov L. (Biol. Blood Marrow Transplant. 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64

Products for MYO1G Gene

Sources for MYO1G Gene

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