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MYO1G Gene

protein-coding   GIFtS: 54
GCID: GC07M045003

Myosin IG

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin IG1 2
HA22 3 5
Minor Histocompatibility Antigen HA-21 2
MHAG2
myosin-Ig2
Unconventional Myosin-Ig2

External Ids:    HGNC: 138801   Entrez Gene: 640052   Ensembl: ENSG000001362867   OMIM: 6134455   UniProtKB: B0I1T23   

Export aliases for MYO1G gene to outside databases

Previous GC identifers: GC07M044648 GC07M044708 GC07M044743 GC07M044742 GC07M044775 GC07M044968


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYO1G Gene:
MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and
mast cells (Pierce et al., 2001 (PubMed 11544309); Patino-Lopez et al., 2010 (PubMed 20071333)).(supplied by
OMIM, Jun 2010)

GeneCards Summary for MYO1G Gene:
MYO1G (myosin IG) is a protein-coding gene. GO annotations related to this gene include motor activity and actin binding. An important paralog of this gene is MYO1D.

UniProtKB/Swiss-Prot: MYO1G_HUMAN, B0I1T2
Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in
intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which
would be moved relative to actin filaments (By similarity)
Function: Precursor of the minor histocompatibility antigen HA-2. More generally, minor histocompatibility
antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response
after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which
are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II
molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft
rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical
sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor
histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I
HLA-A*0201




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYO1G gene promoter:
         AREB6   C/EBPbeta   Sp1   GCNF   GCNF-1   Brachyury   MyoD   GCNF-2   E47   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): MYO1G promoter sequence
   Search Chromatin IP Primers for MYO1G

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYO1G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13-p11.2   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p13-p11.2

MYO1G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO1G gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M045003:  view genomic region     (about GC identifiers)

Start:
45,002,260 bp from pter      End:
45,018,704 bp from pter
Size:
16,445 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 45,041,716-45,058,158     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MYO1G_HUMAN, B0I1T2 (See protein sequence)
Recommended Name: Unconventional myosin-Ig  
Size: 1018 amino acids; 116442 Da
Subunit: Binds calmodulin through its IQ motifs (By similarity)
Caution: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1
(MYH1)
Sequence caution: Sequence=BAB84876.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: Q8TEI9 Q8TES2 Q96BE2 Q96RI5 Q96RI6
Alternative splicing: 4 isoforms:  B0I1T2-1   B0I1T2-2   B0I1T2-3   B0I1T2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYO1G: NX_B0I1T2

Explore proteomics data for MYO1G at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys87, Lys140, Lys164, Lys188, Lys214, Lys341, Lys357, Lys507, Lys518, Lys544,
                                 Lys571, Lys594, Lys690, Lys815, Lys863, Lys898
  • Modification sites at PhosphoSitePlus

  • See MYO1G Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149043.2  
    ENSEMBL proteins: 
     ENSP00000417650   ENSP00000258787   ENSP00000419847  

    MYO1G Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MYO1G

     
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    Cloud-Clone Corp. ELISAs for MYO1G
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MYOI: Myosins / Myosin superfamily : Class I

    4 InterPro protein domains:
     IPR010926 Myosin_tail_2
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS
     IPR001609 Myosin_head_motor_dom

    Graphical View of Domain Structure for InterPro Entry B0I1T2

    ProtoNet protein and cluster: B0I1T2

    UniProtKB/Swiss-Prot: MYO1G_HUMAN, B0I1T2
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 myosin head-like domain


    Find genes that share domains with MYO1G           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYO1G_HUMAN, B0I1T2
    Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in
    intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which
    would be moved relative to actin filaments (By similarity)
    Function: Precursor of the minor histocompatibility antigen HA-2. More generally, minor histocompatibility
    antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response
    after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which
    are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II
    molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft
    rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical
    sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor
    histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I
    HLA-A*0201

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0003779actin binding IEA--
    GO:0005516calmodulin binding IEA--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with MYO1G           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYO1G_HUMAN, B0I1T2: Cell membrane; Peripheral membrane protein. Note=Localization at the membrane is not highly
    dependent on phosphatidylinositol 4,5-bisphosphate levels. Released from the membrane in the presence of ATP. May
    be enriched in peripheral processes, such as microvilli or ruffles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton3
    cytosol3
    golgi apparatus2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA19968988
    GO:0016459myosin complex IEA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with MYO1G           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYO1G About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    wtCFTR and delta508 traffic Clathrin coated vesicles formation norm and CF 0.35
    Transport Clathrin coated vesicle cycle0.66
    2PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    3Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    4RhoGDI Pathway
    Fc-GammaR-Mediated Phagocytosis in Macrophages0.33
    RhoGDI Pathway0.33
    5ERK Signaling
    ILK Signaling0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYO1G (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    2 GeneGo (Thomson Reuters) Pathways for MYO1G
        wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
    Transport Clathrin-coated vesicle cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYO1G
    Interactions:

        Search GeneGlobe Interaction Network for MYO1G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYO1G (B0I1T22, 3 ENSP000002587874) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607092, 3, ENSP000003499604MINT-7307273 I2D: score=1 STRING: ENSP00000349960
    TFRCP027862, 3, ENSP000003532244MINT-7307283 I2D: score=1 STRING: ENSP00000353224
    SVILO954253, ENSP000003481284I2D: score=1 STRING: ENSP00000348128
    CSF1P096033I2D: score=1 
    SRGAP2O750443I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYO1G



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYO1G gene: 
    NM_033054.2  

    Unigene Cluster for MYO1G:

    Myosin IG
    Hs.37617  [show with all ESTs]
    Unigene Representative Sequence: NM_033054
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495831 ENST00000483585(uc003tmi.1) ENST00000488554(uc003tmg.2)
    ENST00000463516 ENST00000258787(uc003tmh.2 uc010kym.2) ENST00000480503
    ENST00000464434(uc003tmj.2)
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      QuantiTect SYBR Green Assays in human, mouse, rat MYO1G
      QuantiFast Probe-based Assays in human, mouse, rat MYO1G

    Additional mRNA sequence: 

    AB290179.1 AF380932.1 AF380933.1 AK097912.1 AL832302.1 BC007370.2 BC015693.2 BC031337.1 
    BC113544.1 BC117241.1 

    8 DOTS entries:

    DT.310180  DT.101980006  DT.100780403  DT.40305730  DT.100761994  DT.100780402  DT.425436  DT.100843209 

    Selected AceView cDNA sequences (see all 96):

    AK074050 CR605274 BM701960 BX400982 CR597530 AI057017 BX365388 BX363216 
    BX344592 AA504190 CD367020 BE674979 BI910371 BX384034 BE270817 BE513809 
    AK097912 CA439676 BG760189 BE646398 BX456560 BI908802 CD366382 AF380933 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYO1G (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
    SP1:                                            -           -                                                           -                                       
    SP2:                          -                 -           -     -                                                     -                       -               
    SP3:                                                                                                                    -                       -               
    SP4:                                            -           -     -                                                     -                                       
    SP5:                                                        -     -                                                                                             

    ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for MYO1G

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYO1G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MYO1G Expression
    About this image


    MYO1G expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
    MYO1G Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYO1G Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.37617

    UniProtKB/Swiss-Prot: MYO1G_HUMAN, B0I1T2
    Tissue specificity: Specifically expressed in hematopoietic cells

        Custom PCR Arrays for MYO1G
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO1G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYO1G gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myo1g1 , 5 myosin IG1, 5 86.23(n)1
    90.95(a)1
      11 (4.30 cM)5
    2461771  NM_178440.41  NP_848534.21 
     65065485 
    chicken
    (Gallus gallus)
    Aves MYO1G1 myosin IG 73.51(n)
    70.32(a)
      420412  NM_001030961.1  NP_001026132.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYO1G6
    myosin IG
    69(a)
    1 ↔ 1
    AAWZ02039506(2740-8425)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-92c9.31 si:dkeyp-92c9.3 63.39(n)
    63.25(a)
      571487  NM_001045221.1  NP_001038686.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Myo31DF6
    Myosin 31DF
    49(a)
    1 → many
    2L(10491682-10506778)
    worm
    (Caenorhabditis elegans)
    Secernentea hum-56
    Protein HUM-5 (hum-5) mRNA, complete cds
    46(a)
    1 → many
    III(4029111-4036840) WBGene00002038
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MYO36
    One of two type I myosins; localizes to actin cort...
    25(a)
    1 → many
    XI(196349-200167) YKL129C


    ENSEMBL Gene Tree for MYO1G (if available)
    TreeFam Gene Tree for MYO1G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYO1G gene
    MYO1D2  MYO15A2  MYO1C2  MYO1A2  MYO1F2  MYO1B2  MYO15B2  MYO1E2  
    MYO1H2  MYO192  
    Selected SIMAP similar genes for MYO1G using alignment to 4 protein entries:     MYO1G_HUMAN (see all proteins) (see all similar genes):
    MYO1D    DKFZp686A01173    MYO9A    MYO9B    MYO1B    MYH11
    MYH9    MYO5C    MYO10    MYO1C    MYO3B    MYO15B
    MYO19    MYO5A    MYH14    MYH10    MYO1E    MYO1A

    Find genes that share paralogs with MYO1G           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYO1G (see all 517)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113226711,2
    C--44893268(+) ATGGA-/T/TT  
            
    TTTTT
    1 -- int1 trp30--------
    rs1478979021,2
    C--45002000(+) CAAGCC/TCTCGC 1 -- int10--------
    rs1884526351,2
    --45002107(+) CTCTGC/GATAGC 1 -- int10--------
    rs2016764511,2
    C--45002304(+) GGACAA/GTTGGC 1 -- ut310--------
    rs2010362381,2
    C--45002312(+) GGCGGC/TCTCGG 1 -- ut310--------
    rs2009589141,2
    C--45002388(+) GAAATA/CGGGCT 2 D Y mis10--------
    rs1932043191,2
    C--45002437(+) CGGACA/CCCGCG 2 G syn10--------
    rs1147776611,2
    C,F--45002518(+) TCAGGG/ACGGCC 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1168659021,2
    F--45002858(+) CACCAG/ACCCCC 1 -- int11Minor allele frequency- A:0.17NA 120
    rs1416961491,2
    --45002900(+) TGACAC/GGGGGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for MYO1G (45002260 - 45018704 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MYO1G:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830985CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MYO1G
    DNA2.0 Custom Variant and Variant Library Synthesis for MYO1G

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613445    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for MYO1G:
    Leukemia

    Find genes that share disorders with MYO1G           About GenesLikeMe

    Genetic Association Database (GAD): MYO1G
    Human Genome Epidemiology (HuGE) Navigator: MYO1G (2 documents)

    Export disorders for MYO1G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYO1G gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with MYO1G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH). (PubMed id 20071333)1, 2 Patino-Lopez G....Shaw S. (J. Biol. Chem. 2010)
    2. Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation. (PubMed id 20353833)1, 4 Larsen M.E....Vindelov L. (Biol. Blood Marrow Transplant. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. The HA-2 minor histocompatibility antigen is derived from a diallelic gene encoding a novel human class I myosin protein. (PubMed id 11544309)1, 2 Pierce R.A.... Engelhard V.H. (J. Immunol. 2001)
    6. Identification of a graft versus host disease-associated human minor histocompatibility antigen. (PubMed id 7539551)1, 2 den Haan J.M.M....Goulmy E. (Science 1995)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64005 HGNC: 13880 AceView: MYO1G Ensembl:ENSG00000136286 euGenes: HUgn64005
    ECgene: MYO1G H-InvDB: MYO1G

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYO1G Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYO1G gene:
    Search GeneIP for patents involving MYO1G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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