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Aliases for MYO1F Gene

Aliases for MYO1F Gene

  • Myosin IF 2 3 5
  • Myosin-Ie 3 4
  • Unconventional Myosin-If 3
  • Myosin-ID 3

External Ids for MYO1F Gene

Previous GeneCards Identifiers for MYO1F Gene

  • GC19M008814
  • GC19M008480
  • GC19M008491
  • GC19M008241
  • GC19M008585

Summaries for MYO1F Gene

GeneCards Summary for MYO1F Gene

MYO1F (Myosin IF) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Delta508-CFTR traffic / ER-to-Golgi in CF. GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYO1E.

UniProtKB/Swiss-Prot for MYO1F Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).

Gene Wiki entry for MYO1F Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO1F Gene

Genomics for MYO1F Gene

Regulatory Elements for MYO1F Gene

Enhancers for MYO1F Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F008574 1.1 FANTOM5 ENCODE 43.4 +1.1 1115 3.4 PKNOX1 ARID4B ZNF48 YY1 ZNF121 NFIL3 ATF4 ETV4 PBX2 KDM1A MYO1F PRAM1 ENSG00000267986 MARCH2 ENSG00000279396 GC19M008577
GH19F008566 1.4 FANTOM5 ENCODE 40.2 +7.0 6951 7.5 ATF1 SIN3A DMAP1 YY1 ZNF121 FOS ZNF548 NFYC JUNB TBX21 MYO1F HNRNPM ZNF699 ZNF558 ELAVL1 ZNF559 XAB2 PRAM1 ENSG00000267986 ZNF426
GH19F008637 1 FANTOM5 Ensembl ENCODE 31.2 -62.0 -62024 3.6 ELF3 ARID4B THRB ZNF48 RARA YY1 ZNF121 SLC30A9 CREM THAP11 MYO1F ADAMTS10 ACTL9 PRAM1 LOC100128428 LINC01862 ENSG00000261866 GC19P008677
GH19F008542 0.7 FANTOM5 20.8 +35.2 35166 0.3 ZNF263 KLF1 MAZ KLF17 ZBTB8A ZFHX2 ZBTB48 PATZ1 EGR2 SP7 MYO1F PRAM1 RAB11B ENSG00000268618 ZNF414
GH19F008541 0.6 FANTOM5 20.7 +36.4 36402 0.4 ATF1 CEBPB CEBPG MYO1F PRAM1 MARCH2 ENSG00000268618 ZNF414
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MYO1F on UCSC Golden Path with GeneCards custom track

Promoters for MYO1F Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001815865 977 2001 PKNOX1 ARID4B ZNF48 YY1 ZNF121 NFIL3 ATF4 ETV4 PBX2 KDM1A

Genomic Location for MYO1F Gene

Chromosome:
19
Start:
8,520,790 bp from pter
End:
8,577,577 bp from pter
Size:
56,788 bases
Orientation:
Minus strand

Genomic View for MYO1F Gene

Genes around MYO1F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO1F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO1F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO1F Gene

Proteins for MYO1F Gene

  • Protein details for MYO1F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00160-MYO1F_HUMAN
    Recommended name:
    Unconventional myosin-If
    Protein Accession:
    O00160
    Secondary Accessions:
    • Q8WWN7

    Protein attributes for MYO1F Gene

    Size:
    1098 amino acids
    Molecular mass:
    124844 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MYO1F Gene

Post-translational modifications for MYO1F Gene

  • Ubiquitination at Lys 170, Lys 355, Lys 673, and Lys 905
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MYO1F Gene

Domains & Families for MYO1F Gene

Gene Families for MYO1F Gene

Suggested Antigen Peptide Sequences for MYO1F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00160

UniProtKB/Swiss-Prot:

MYO1F_HUMAN :
  • Contains 1 IQ domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • Contains 1 IQ domain.
  • Contains 1 myosin motor domain.
  • Contains 1 SH3 domain.
  • Contains 1 TH1 (class I myosin tail homology) domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO1F: view

Function for MYO1F Gene

Molecular function for MYO1F Gene

GENATLAS Biochemistry:
myosin IF,unconventional,apparently non filamentous,homologous to mouse Myo1f,widely expressed,but not in the heart
UniProtKB/Swiss-Prot Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).

Gene Ontology (GO) - Molecular Function for MYO1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding NAS 9119401
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding NAS 9119401
genes like me logo Genes that share ontologies with MYO1F: view
genes like me logo Genes that share phenotypes with MYO1F: view

Animal Models for MYO1F Gene

MGI Knock Outs for MYO1F:

Animal Model Products

miRNA for MYO1F Gene

miRTarBase miRNAs that target MYO1F

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYO1F Gene

Localization for MYO1F Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO1F Gene COMPARTMENTS Subcellular localization image for MYO1F gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for MYO1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016459 myosin complex IEA --
GO:0016461 unconventional myosin complex NAS 9119401
genes like me logo Genes that share ontologies with MYO1F: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYO1F Gene

Pathways & Interactions for MYO1F Gene

genes like me logo Genes that share pathways with MYO1F: view

Gene Ontology (GO) - Biological Process for MYO1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MYO1F: view

No data available for SIGNOR curated interactions for MYO1F Gene

Transcripts for MYO1F Gene

Unigene Clusters for MYO1F Gene

Myosin IF:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO1F Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - -
SP2:
SP3: -
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9:

ExUns: 19a · 19b · 19c ^ 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for MYO1F Gene

GeneLoc Exon Structure for
MYO1F
ECgene alternative splicing isoforms for
MYO1F

Expression for MYO1F Gene

mRNA expression in normal human tissues for MYO1F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYO1F Gene

This gene is overexpressed in Whole Blood (x38.8).

Protein differential expression in normal tissues from HIPED for MYO1F Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.9), Cervix (14.5), Tlymphocyte (9.4), NK cells (8.3), and Monocytes (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYO1F Gene



Protein tissue co-expression partners for MYO1F Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MYO1F Gene:

MYO1F

SOURCE GeneReport for Unigene cluster for MYO1F Gene:

Hs.465818
genes like me logo Genes that share expression patterns with MYO1F: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MYO1F Gene

Orthologs for MYO1F Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYO1F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO1F 34 35
  • 96.03 (n)
dog
(Canis familiaris)
Mammalia MYO1F 34 35
  • 89.69 (n)
cow
(Bos Taurus)
Mammalia MYO1F 34 35
  • 89.4 (n)
oppossum
(Monodelphis domestica)
Mammalia MYO1F 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo1f 34 16 35
  • 86.25 (n)
rat
(Rattus norvegicus)
Mammalia Myo1f 34
  • 86.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYO1F 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYO1F 34 35
  • 79.49 (n)
lizard
(Anolis carolinensis)
Reptilia MYO1F 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo1f 34
  • 70.02 (n)
zebrafish
(Danio rerio)
Actinopterygii myo1f 34 35
  • 71.21 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3889 34
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL306C 34
  • 51.54 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO5 34 37
  • 46.89 (n)
MYO3 35
  • 33 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12562g 34
  • 46.8 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02111 34
  • 52.29 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes myo1 34
  • 46.6 (n)
Species where no ortholog for MYO1F was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO1F Gene

ENSEMBL:
Gene Tree for MYO1F (if available)
TreeFam:
Gene Tree for MYO1F (if available)

Paralogs for MYO1F Gene

Variants for MYO1F Gene

Sequence variations from dbSNP and Humsavar for MYO1F Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401267 -- 8,541,891(+) CCATG(C/T)CTGGG intron-variant
rs10401387 -- 8,557,286(+) aacaa(A/C)caacc intron-variant
rs10402716 -- 8,525,286(+) TGGGT(G/T)TGGGT intron-variant
rs10403664 -- 8,560,570(+) ttttt(C/T)gtttt intron-variant
rs10405687 -- 8,545,976(+) GCTCT(A/G)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO1F Gene

Variant ID Type Subtype PubMed ID
dgv137n111 CNV deletion 26073780
dgv396n27 CNV loss 19166990
dgv6258n54 CNV loss 21841781
esv2661355 CNV deletion 23128226
esv2718125 CNV deletion 23290073
esv2718126 CNV deletion 23290073
esv2762024 CNV gain 21179565
esv3363685 CNV insertion 20981092
esv3643618 CNV gain 21293372
esv3643619 CNV gain 21293372
nsv1127648 CNV deletion 24896259
nsv1138665 CNV deletion 24896259
nsv1143908 CNV deletion 24896259
nsv458350 CNV loss 19166990
nsv528946 CNV loss 19592680
nsv578559 CNV loss 21841781
nsv953966 CNV deletion 24416366

Variation tolerance for MYO1F Gene

Residual Variation Intolerance Score: 9.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO1F Gene

Human Gene Mutation Database (HGMD)
MYO1F
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYO1F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO1F Gene

Disorders for MYO1F Gene

Relevant External Links for MYO1F

Genetic Association Database (GAD)
MYO1F
Human Genome Epidemiology (HuGE) Navigator
MYO1F
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO1F

No disorders were found for MYO1F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYO1F Gene

Publications for MYO1F Gene

  1. Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. (PMID: 9119401) Crozet F. … Petit C. (Genomics 1997) 2 3 4 64
  2. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 46 64
  3. Are MYO1C and MYO1F associated with hearing loss? (PMID: 19027848) Zadro C. … Carella M. (Biochim. Biophys. Acta 2009) 3 46 64
  4. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for MYO1F Gene

Sources for MYO1F Gene

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