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Aliases for MYO1F Gene

Aliases for MYO1F Gene

  • Myosin IF 2 3
  • Myosin-Ie 3 4
  • Unconventional Myosin-If 3
  • Myosin-ID 3

External Ids for MYO1F Gene

Summaries for MYO1F Gene

GeneCards Summary for MYO1F Gene

MYO1F (Myosin IF) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and ERK Signaling. GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYO1D.

UniProtKB/Swiss-Prot for MYO1F Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).

Gene Wiki entry for MYO1F Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO1F Gene

Genomics for MYO1F Gene

Genomic Location for MYO1F Gene

Start:
8,520,790 bp from pter
End:
8,577,577 bp from pter
Size:
56,788 bases
Orientation:
Minus strand

Genomic View for MYO1F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYO1F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO1F Gene

Regulatory Elements for MYO1F Gene

Proteins for MYO1F Gene

  • Protein details for MYO1F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00160-MYO1F_HUMAN
    Recommended name:
    Unconventional myosin-If
    Protein Accession:
    O00160
    Secondary Accessions:
    • Q8WWN7

    Protein attributes for MYO1F Gene

    Size:
    1098 amino acids
    Molecular mass:
    124844 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MYO1F Gene

Proteomics data for MYO1F Gene at MOPED

Post-translational modifications for MYO1F Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys158, Lys170, Lys194, Lys355, Lys673, and Lys905

Other Protein References for MYO1F Gene

No data available for DME Specific Peptides for MYO1F Gene

Domains for MYO1F Gene

Gene Families for MYO1F Gene

HGNC:
  • MYOI :Myosins / Myosin superfamily : Class I

UniProtKB/Swiss-Prot:

MYO1F_HUMAN
Domain:
  • Contains 1 IQ domain.:
    • O00160
  • Contains 1 myosin motor domain.:
    • O00160
  • Contains 1 myosin tail domain.:
    • O00160
  • Contains 1 SH3 domain.:
    • O00160
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.:
    • O00160
genes like me logo Genes that share domains with MYO1F: view

Function for MYO1F Gene

Molecular function for MYO1F Gene

GENATLAS Biochemistry: myosin IF,unconventional,apparently non filamentous,homologous to mouse Myo1f,widely expressed,but not in the heart
UniProtKB/Swiss-Prot Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).

Gene Ontology (GO) - Molecular Function for MYO1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding NAS 9119401
GO:0005515 protein binding --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding NAS 9119401
genes like me logo Genes that share ontologies with MYO1F: view

Phenotypes for MYO1F Gene

genes like me logo Genes that share phenotypes with MYO1F: view

Animal Models for MYO1F Gene

MGI Knock Outs for MYO1F:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MYO1F Gene

Localization for MYO1F Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO1F Gene COMPARTMENTS Subcellular localization image for MYO1F gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MYO1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016459 myosin complex --
GO:0016461 unconventional myosin complex NAS 9119401
GO:0030864 cortical actin cytoskeleton IEA --
GO:0031941 filamentous actin IEA --
genes like me logo Genes that share ontologies with MYO1F: view

Pathways for MYO1F Gene

genes like me logo Genes that share pathways with MYO1F: view

Pathways by source for MYO1F Gene

Gene Ontology (GO) - Biological Process for MYO1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002446 neutrophil mediated immunity --
GO:0007162 negative regulation of cell adhesion IEA --
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
GO:0030335 positive regulation of cell migration IEA --
genes like me logo Genes that share ontologies with MYO1F: view

Transcripts for MYO1F Gene

Unigene Clusters for MYO1F Gene

Myosin IF:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYO1F Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - -
SP2:
SP3: -
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9:

ExUns: 19a · 19b · 19c ^ 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for MYO1F Gene

GeneLoc Exon Structure for
MYO1F
ECgene alternative splicing isoforms for
MYO1F

Expression for MYO1F Gene

mRNA expression in normal human tissues for MYO1F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYO1F Gene

This gene is overexpressed in Whole Blood (38.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYO1F Gene

SOURCE GeneReport for Unigene cluster for MYO1F Gene Hs.465818

genes like me logo Genes that share expressions with MYO1F: view

Orthologs for MYO1F Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYO1F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO1F 36
  • 96.03 (n)
  • 95.01 (a)
MYO1F 37
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYO1F 36
  • 89.4 (n)
  • 95.17 (a)
MYO1F 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO1F 36
  • 89.69 (n)
  • 92.99 (a)
MYO1F 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo1f 36
  • 86.25 (n)
  • 93.72 (a)
Myo1f 16
Myo1f 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYO1F 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYO1F 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myo1f 36
  • 86.25 (n)
  • 93.72 (a)
chicken
(Gallus gallus)
Aves MYO1F 36
  • 79.49 (n)
  • 84.43 (a)
MYO1F 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYO1F 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo1f 36
  • 70.02 (n)
  • 79.8 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3889 36
zebrafish
(Danio rerio)
Actinopterygii myo1f 36
  • 71.21 (n)
  • 77.74 (a)
myo1f 37
  • 77 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL306C 36
  • 51.54 (n)
  • 47.9 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO3 37
  • 33 (a)
OneToMany
MYO5 36
  • 46.89 (n)
  • 43.19 (a)
MYO5 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12562g 36
  • 46.8 (n)
  • 44.16 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02111 36
  • 52.29 (n)
  • 42.56 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes myo1 36
  • 46.6 (n)
  • 43.68 (a)
Species with no ortholog for MYO1F:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO1F Gene

ENSEMBL:
Gene Tree for MYO1F (if available)
TreeFam:
Gene Tree for MYO1F (if available)

Paralogs for MYO1F Gene

Paralogs for MYO1F Gene

genes like me logo Genes that share paralogs with MYO1F: view

Variants for MYO1F Gene

Sequence variations from dbSNP and Humsavar for MYO1F Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1054618 -- 8,521,333(-) CTGGT(C/T)TTCCT utr-variant-3-prime
rs1054619 -- 8,521,303(-) CCATT(C/T)TCCAT utr-variant-3-prime
rs1054621 -- 8,521,263(-) AGAAT(C/T)TACCT utr-variant-3-prime
rs1054622 -- 8,521,237(-) ATTAA(A/G)AAATG utr-variant-3-prime
rs1054623 -- 8,521,202(-) AAAGT(G/T)CCAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MYO1F Gene

Variant ID Type Subtype PubMed ID
nsv911004 CNV Loss 21882294
dgv3720n71 CNV Loss 21882294
dgv3721n71 CNV Loss 21882294
nsv458350 CNV Loss 19166990
dgv396n27 CNV Loss 19166990
dgv3722n71 CNV Loss 21882294
esv269938 CNV Insertion 20981092
esv2718125 CNV Deletion 23290073
esv2661355 CNV Deletion 23128226
nsv528946 CNV Loss 19592680
nsv911018 CNV Loss 21882294
esv2718126 CNV Deletion 23290073

Relevant External Links for MYO1F Gene

HapMap Linkage Disequilibrium report
MYO1F
Human Gene Mutation Database (HGMD)
MYO1F

Disorders for MYO1F Gene

Relevant External Links for MYO1F

Genetic Association Database (GAD)
MYO1F
Human Genome Epidemiology (HuGE) Navigator
MYO1F
genes like me logo Genes that share disorders with MYO1F: view

No data available for UniProtKB/Swiss-Prot for MYO1F Gene

Publications for MYO1F Gene

  1. Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. (PMID: 9119401) Crozet F. … Petit C. (Genomics 1997) 2 3 4
  2. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. (PMID: 11804589) Krugmann S. … Hawkins P.T. (Mol. Cell 2002) 3 4
  3. Mapping of unconventional myosins in mouse and human. (PMID: 8884266) Hasson T. … Jenkins N.A. (Genomics 1996) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MYO1F Gene

Sources for MYO1F Gene

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