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MYO1F Gene

protein-coding   GIFtS: 58
GCID: GC19M008585

Myosin IF

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin IF1 2
myosin-ID2
myosin-Ie2
Unconventional Myosin-If2
Myosin-Ie3

External Ids:    HGNC: 76001   Entrez Gene: 45422   Ensembl: ENSG000001423477   OMIM: 6014805   UniProtKB: O001603   

Export aliases for MYO1F gene to outside databases

Previous GC identifers: GC19M008814 GC19M008480 GC19M008491 GC19M008241


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYO1F Gene:
MYO1F (myosin IF) is a protein-coding gene. Diseases associated with MYO1F include acute monocytic leukemia, and monocytic leukemia. GO annotations related to this gene include motor activity and actin binding. An important paralog of this gene is MYO1D.

UniProtKB/Swiss-Prot: MYO1F_HUMAN, O00160
Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in
intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which
would be moved relative to actin filaments (By similarity)

Gene Wiki entry for MYO1F Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYO1F gene promoter:
         GR   SREBP-1c   Bach2   SREBP-1b   FAC1   SREBP-1a   HOXA5   FOXJ2 (long isoform)   GR-alpha   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYO1F promoter sequence
   Search Chromatin IP Primers for MYO1F

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYO1F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3-p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.3-p13.2

MYO1F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO1F gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M008585:  view genomic region     (about GC identifiers)

Start:
8,585,674 bp from pter      End:
8,642,461 bp from pter
Size:
56,788 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MYO1F_HUMAN, O00160 (See protein sequence)
Recommended Name: Unconventional myosin-If  
Size: 1098 amino acids; 124844 Da
Caution: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1
(MYH1)
Secondary accessions: Q8WWN7

Explore the universe of human proteins at neXtProt for MYO1F: NX_O00160

Explore proteomics data for MYO1F at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys158, Lys170, Lys194, Lys355, Lys673, Lys905
  • Modification sites at PhosphoSitePlus

  • See MYO1F Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036467.2  
    ENSEMBL proteins: 
     ENSP00000344871   ENSP00000469098   ENSP00000469380   ENSP00000469387   ENSP00000469668  

    MYO1F Human Recombinant Protein Products:

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    Novus Biologicals MYO1F Protein
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    Cloud-Clone Corp. Proteins for MYO1F

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    Abcam antibodies for MYO1F
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    MYO1F Assay Products:

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    GenScript Custom Assay Services for MYO1F
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    Cloud-Clone Corp. ELISAs for MYO1F
    Cloud-Clone Corp. CLIAs for MYO1F


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MYOI: Myosins / Myosin superfamily : Class I

    5 InterPro protein domains:
     IPR010926 Myosin_tail_2
     IPR001452 SH3_domain
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS
     IPR001609 Myosin_head_motor_dom

    Graphical View of Domain Structure for InterPro Entry O00160

    ProtoNet protein and cluster: O00160

    3 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB001452 SH3 domain signature
    IPB010926 Myosin tail 2


    UniProtKB/Swiss-Prot: MYO1F_HUMAN, O00160
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 myosin head-like domain
    Similarity: Contains 1 SH3 domain


    MYO1F for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYO1F_HUMAN, O00160
    Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in
    intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which
    would be moved relative to actin filaments (By similarity)

         Genatlas biochemistry entry for MYO1F:
    myosin IF,unconventional,apparently non filamentous,homologous to mouse Myo1f,widely expressed,but not in the
    heart

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0003779actin binding NAS9119401
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
    GO:0005524ATP binding NAS9119401
         
    MYO1F for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MYO1F:
     Increased cell number in S 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Myo1f):
     cellular  hematopoietic system  immune system  no phenotypic analysis 

    MYO1F for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Myo1ftm1.1Flv for MYO1F

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYO1F
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYO1F
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MYO1F (see all 12):
    hsa-miR-98 hsa-miR-137 hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-3918 hsa-let-7e hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidMYO1F 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MYO1F
    Predesigned siRNA for gene silencing in human, mouse, rat MYO1F

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: MYO1F (NM_012335)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYO1F
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO1F

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO1F


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016459myosin complex ----
    GO:0016461unconventional myosin complex NAS9119401
    GO:0030864cortical actin cytoskeleton IEA--
    GO:0031941filamentous actin IEA--

    MYO1F for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYO1F About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    wtCFTR and delta508 traffic Clathrin coated vesicles formation norm and CF 0.35
    Transport Clathrin coated vesicle cycle0.66
    2PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    3Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    4RhoGDI Pathway
    Fc-GammaR-Mediated Phagocytosis in Macrophages0.33
    RhoGDI Pathway0.33
    5ERK Signaling
    ILK Signaling0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYO1F (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    2 GeneGo (Thomson Reuters) Pathways for MYO1F
        wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
    Transport Clathrin-coated vesicle cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYO1F
    Interactions:

        Search GeneGlobe Interaction Network for MYO1F

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYO1F (O001603 ENSP000003448714) via UniProtKB, MINT, STRING, and/or I2D (see all 429)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002446neutrophil mediated immunity ----
    GO:0007162negative regulation of cell adhesion IEA--
    GO:0008150biological_process ND--
    GO:0030335positive regulation of cell migration IEA--
    GO:0032956regulation of actin cytoskeleton organization IEA--

    MYO1F for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYO1F



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MYO1F gene: 
    NM_012335.3  

    Unigene Cluster for MYO1F:

    Myosin IF
    Hs.465818  [show with all ESTs]
    Unigene Representative Sequence: AB290178
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000338257(uc002mkg.3 uc010xkf.2) ENST00000600885 ENST00000596245
    ENST00000598005 ENST00000597459 ENST00000598797 ENST00000597222 ENST00000602136
    ENST00000601502 ENST00000594977 ENST00000600825 ENST00000596937 ENST00000595191
    ENST00000598529 ENST00000595325 ENST00000594774 ENST00000598321 ENST00000599123

    miRNA
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    Block miRNA regulation of human, mouse, rat MYO1F using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYO1F (see all 12):
    hsa-miR-98 hsa-miR-137 hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-3918 hsa-let-7e hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidMYO1F 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MYO1F
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    GenScript: all cDNA clones in your preferred vector: MYO1F (NM_012335)
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    Primer
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    OriGene qPCR primer pairs and template standards for MYO1F
    OriGene qSTAR qPCR primer pairs in human, mouse for MYO1F
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYO1F
      QuantiTect SYBR Green Assays in human, mouse, rat MYO1F
      QuantiFast Probe-based Assays in human, mouse, rat MYO1F

    Additional mRNA sequence: 

    AB210037.1 AB290178.1 AJ310570.1 AK131106.1 AK301166.1 AK310058.1 BC028071.1 L29140.1 
    X98411.1 

    16 DOTS entries:

    DT.404979  DT.121486580  DT.100009383  DT.100704227  DT.40204813  DT.95122443  DT.95278635  DT.95278637 
    DT.95362137  DT.100058822  DT.91649118  DT.92429877  DT.95278636  DT.97762603  DT.99967723  DT.97841210 

    Selected AceView cDNA sequences (see all 94):

    BM714360 BQ708244 BI909321 CR607653 BX341001 BI018833 BI822146 BM273206 
    BQ231408 NM_012335 BM675164 CR601457 CD672679 CD367144 CK820113 BM354188 
    AI251110 BC028071 BX097457 BF340160 BM991637 AL554166 AK131106 BQ710600 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYO1F (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                                                                          -           -                                                                     
    SP2:                                                                                                                                                            
    SP3:                          -                                                                                                                                 
    SP4:                                                                          -                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 19a · 19b · 19c ^ 20 ^ 21
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for MYO1F

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYO1F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATTAAGAA
    MYO1F Expression
    About this image


    MYO1F expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Spleen (Hematopoietic System)
    MYO1F Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYO1F Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465818
        Custom PCR Arrays for MYO1F
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MYO1F
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO1F

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYO1F gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myo1f1 , 5 myosin IF1, 5 86.25(n)1
    93.72(a)1
      17 (17.98 cM)5
    179161  NM_053214.21  NP_444444.21 
     335557195 
    chicken
    (Gallus gallus)
    Aves MYO1F1 myosin IF 79.49(n)
    84.43(a)
      396187  NM_205254.1  NP_990585.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYO1F6
    myosin IF
    87(a)
    1 ↔ 1
    AAWZ02037949(297-13842)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BG816217.12   -- 78.77(n)    BG816217.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myo1f1 myosin IF 71.21(n)
    77.74(a)
      565345  NM_001256671.1  NP_001243600.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MYO5(YMR109W)4
    MYO51
    One of two type I myosins; contains proline-rich tail more4
    MYO51
    46.89(n)1
    43.19(a)1
      13(486587-490246)4
    8551361, 4  NP_013827.11, 4 


    ENSEMBL Gene Tree for MYO1F (if available)
    TreeFam Gene Tree for MYO1F (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYO1F gene
    MYO1D2  MYO15A2  MYO1C2  MYO1A2  MYO1G2  MYO1B2  MYO15B2  MYO1E2  
    MYO1H2  MYO192  
    Selected SIMAP similar genes for MYO1F using alignment to 6 protein entries:     MYO1F_HUMAN (see all proteins) (see all similar genes):
    MYO1F variant protein    FLJ00395    MYO1E    SH3GL2    MYO1C    MYO1B
    MYO1H    MYO6    MYO5C    MYO7B    DKFZp686A01173    MYO15A
    MYO1D    MYO5A    MYO1A    MYO1G    MYH9    MYO9A

    MYO1F for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYO1F (see all 1676)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1114869361,2
    C--8585302(+) CCTCCC/TGAGCA 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1389699201,2
    C--8585326(+) GCGCCC/TGCCAC 1 -- ds50010--------
    rs1422148111,2
    --8585334(+) CACCAC/TGCCCG 1 -- ds50010--------
    rs1126895681,2
    F--8585638(+) GATTAT/CAGGCA 1 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs1829391781,2
    --8585642(+) ACAGGC/GAGGCA 1 -- ds50010--------
    rs29139221,2
    C,F,A,H--8585755(+) CTGCCC/TGCCTC 1 -- ut312Minor allele frequency- T:0.50NA 6
    rs1167896561,2
    F--8585906(+) TTGTTC/TCACCT 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs342761161,2
    C--8586060(+) AAGGA-/CCCCCC 1 -- ut310--------
    rs1861034331,2
    --8586061(+) AAGGAA/CCCCCC 1 -- ut310--------
    rs10546231,2
    C,F,O,A,H--8586086(-) AAAGTG/TCCAGG 1 -- ut31 ese322Minor allele frequency- T:0.23EA MN NS NA WA 4012

    HapMap Linkage Disequilibrium report for MYO1F (8585674 - 8642461 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MYO1F (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718126CNV Deletion23290073
    esv2661355CNV Deletion23128226
    esv2718125CNV Deletion23290073
    esv269938CNV Insertion20981092
    dgv3721n71CNV Loss21882294
    nsv528946CNV Loss19592680
    nsv911004CNV Loss21882294
    dgv396n27CNV Loss19166990
    nsv911018CNV Loss21882294
    dgv3722n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): MYO1F
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYO1F
    DNA2.0 Custom Variant and Variant Library Synthesis for MYO1F

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601480    OMIM disorders: --

    3 diseases for MYO1F:    
    About MalaCards
    acute monocytic leukemia    monocytic leukemia    leukemia


    MYO1F for disorders           About GeneDecksing

    Genetic Association Database (GAD): MYO1F
    Human Genome Epidemiology (HuGE) Navigator: MYO1F (1 document)

    Export disorders for MYO1F gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYO1F gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with MYO1F)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. (PubMed id 9119401)1, 2, 3 Crozet F.... Petit C. (Genomics 1997)
    2. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    3. Are MYO1C and MYO1F associated with hearing loss? (PubMed id 19027848)1, 4 Zadro C....Carella M. (Biochim. Biophys. Acta 2009)
    4. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. (PubMed id 11804589)1, 2 Krugmann S....Hawkins P.T. (Mol. Cell 2002)
    8. Mapping of unconventional myosins in mouse and human. (PubMed id 8884266)1, 3 Hasson T.... Jenkins N.A. (Genomics 1996)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4542 HGNC: 7600 AceView: MYO1F Ensembl:ENSG00000142347 euGenes: HUgn4542
    ECgene: MYO1F H-InvDB: MYO1F

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYO1F Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYO1F gene:
    Search GeneIP for patents involving MYO1F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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