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Aliases for MYO1D Gene

Aliases for MYO1D Gene

  • Myosin ID 2 3
  • KIAA0727 4 6
  • Protein Phosphatase 1, Regulatory Subunit 108 3
  • Unconventional Myosin-Id 3
  • Regulatory Subunit 108 2
  • Protein Phosphatase 1 2
  • Myosin-I Gamma 3
  • PPP1R108 3
  • Myr4 3

External Ids for MYO1D Gene

Summaries for MYO1D Gene

GeneCards Summary for MYO1D Gene

MYO1D (Myosin ID) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and ERK Signaling. GO annotations related to this gene include actin binding and calcium-dependent protein binding. An important paralog of this gene is MYO1H.

UniProtKB/Swiss-Prot for MYO1D Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO1D Gene

Genomics for MYO1D Gene

Genomic Location for MYO1D Gene

32,492,522 bp from pter
32,877,177 bp from pter
384,656 bases
Minus strand

Genomic View for MYO1D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYO1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO1D Gene

Regulatory Elements for MYO1D Gene

Proteins for MYO1D Gene

  • Protein details for MYO1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Unconventional myosin-Id
    Protein Accession:
    Secondary Accessions:
    • A6H8V3
    • Q8NHP9

    Protein attributes for MYO1D Gene

    1006 amino acids
    Molecular mass:
    116202 Da
    Quaternary structure:
    • Binds calmodulin through its IQ motifs.
    • Sequence=BAA34447.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MYO1D Gene

Proteomics data for MYO1D Gene at MOPED

Post-translational modifications for MYO1D Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys559, Lys767, and Lys811

Other Protein References for MYO1D Gene

No data available for DME Specific Peptides for MYO1D Gene

Domains for MYO1D Gene

Gene Families for MYO1D Gene

  • MYOI :Myosins / Myosin superfamily : Class I

Suggested Antigen Peptide Sequences for MYO1D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 IQ domains.:
    • O94832
  • Contains 1 myosin motor domain.:
    • O94832
  • Contains 1 myosin tail domain.:
    • O94832
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.:
    • O94832
genes like me logo Genes that share domains with MYO1D: view

Function for MYO1D Gene

Molecular function for MYO1D Gene

GENATLAS Biochemistry: myosin ID,unconventional,apparently non filamentous,homologous to mouse Myo1f,expressed in cochlea
UniProtKB/Swiss-Prot Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).

Gene Ontology (GO) - Molecular Function for MYO1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000146 microfilament motor activity IEA --
GO:0003774 motor activity --
GO:0003779 actin binding --
GO:0005515 protein binding --
GO:0005516 calmodulin binding ISS --
genes like me logo Genes that share ontologies with MYO1D: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MYO1D Gene

Localization for MYO1D Gene

Subcellular locations from

Jensen Localization Image for MYO1D Gene COMPARTMENTS Subcellular localization image for MYO1D gene
Compartment Confidence
cytoskeleton 3
cytosol 3
endoplasmic reticulum 2
nucleus 2
plasma membrane 2
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MYO1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome ISS --
GO:0005790 smooth endoplasmic reticulum IEA --
GO:0005903 brush border ISS --
GO:0016323 basolateral plasma membrane ISS --
GO:0016459 myosin complex IEA --
genes like me logo Genes that share ontologies with MYO1D: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYO1D Gene

Pathways for MYO1D Gene

genes like me logo Genes that share pathways with MYO1D: view

Gene Ontology (GO) - Biological Process for MYO1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0008152 metabolic process IEA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0051641 cellular localization ISS --
GO:0061502 early endosome to recycling endosome transport ISS --
genes like me logo Genes that share ontologies with MYO1D: view

Compounds for MYO1D Gene

(1) Drugbank Compounds for MYO1D Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
20398-34-9 target
genes like me logo Genes that share compounds with MYO1D: view

Transcripts for MYO1D Gene

Unigene Clusters for MYO1D Gene

Myosin ID:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYO1D Gene

No ASD Table

Relevant External Links for MYO1D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYO1D Gene

mRNA expression in normal human tissues for MYO1D Gene

mRNA differential expression in normal tissues according to GTEx for MYO1D Gene

This gene is overexpressed in Artery - Aorta (7.7), Artery - Tibial (5.5), and Artery - Coronary (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYO1D Gene

SOURCE GeneReport for Unigene cluster for MYO1D Gene Hs.602063

mRNA Expression by UniProt/SwissProt for MYO1D Gene

Tissue specificity: Expressed in many tissues. Highest levels in brain, followed by lung and ovary; expression is lowest in spleen
genes like me logo Genes that share expressions with MYO1D: view

Orthologs for MYO1D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYO1D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MYO1D 35
  • 99.6 (n)
  • 99.6 (a)
MYO1D 36
  • 100 (a)
(Bos Taurus)
Mammalia MYO1D 35
  • 90.56 (n)
  • 97.22 (a)
MYO1D 36
  • 97 (a)
(Canis familiaris)
Mammalia MYO1D 35
  • 92.61 (n)
  • 98.41 (a)
MYO1D 36
  • 98 (a)
(Mus musculus)
Mammalia Myo1d 35
  • 90.46 (n)
  • 97.71 (a)
Myo1d 16
Myo1d 36
  • 98 (a)
(Monodelphis domestica)
Mammalia MYO1D 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia MYO1D 36
  • 88 (a)
(Rattus norvegicus)
Mammalia Myo1d 35
  • 90.49 (n)
  • 98.01 (a)
(Gallus gallus)
Aves MYO1D 35
  • 78.51 (n)
  • 88.86 (a)
MYO1D 36
  • 84 (a)
(Anolis carolinensis)
Reptilia MYO1D 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia myo1d 35
  • 71.97 (n)
  • 80.52 (a)
(Danio rerio)
Actinopterygii MYO1D 36
  • 81 (a)
si:ch211-94l19.4 35
  • 72.58 (n)
  • 80.98 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010160 35
  • 35.1 (n)
  • 19.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Myo31DF 35
  • 55.64 (n)
  • 54.47 (a)
Myo31DF 36
  • 54 (a)
(Caenorhabditis elegans)
Secernentea hum-5 35
  • 55.05 (n)
  • 51.84 (a)
hum-5 36
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO3 36
  • 26 (a)
(Zea mays)
Liliopsida Zm.442 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
Species with no ortholog for MYO1D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYO1D Gene

Gene Tree for MYO1D (if available)
Gene Tree for MYO1D (if available)

Paralogs for MYO1D Gene

Paralogs for MYO1D Gene

genes like me logo Genes that share paralogs with MYO1D: view

Variants for MYO1D Gene

Sequence variations from dbSNP and Humsavar for MYO1D Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs25578 -- 32,754,913(-) AGATC(-/ACATATC)TGTAG intron-variant
rs167675 -- 32,692,978(+) ATTCA(C/G)TGGGA intron-variant
rs188919 -- 32,580,172(-) cttaa(A/G)atAGG intron-variant
rs192010 -- 32,580,069(-) CATGG(G/T)GGGaa intron-variant
rs224455 -- 32,688,238(-) TTTTA(C/T)AAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO1D Gene

Variant ID Type Subtype PubMed ID
nsv519839 CNV Loss 19592680
nsv908070 CNV Loss 21882294
esv270522 CNV Insertion 20981092
esv274212 CNV Insertion 20981092
esv1340589 CNV Insertion 17803354
esv270635 CNV Insertion 20981092
nsv908071 CNV Loss 21882294
nsv908072 CNV Gain 21882294
nsv833415 CNV Gain 17160897
esv2670976 CNV Deletion 23128226
nsv833416 CNV Gain 17160897
esv267480 CNV Insertion 20981092
esv273461 CNV Insertion 20981092
nsv507839 CNV Insertion 20534489
nsv510705 CNV Loss 20534489
nsv833417 CNV Gain 17160897

Relevant External Links for MYO1D Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO1D Gene

Disorders for MYO1D Gene

(1) University of Copenhagen DISEASES for MYO1D Gene

Relevant External Links for MYO1D

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MYO1D: view

No data available for UniProtKB/Swiss-Prot for MYO1D Gene

Publications for MYO1D Gene

  1. Mapping of unconventional myosins in mouse and human. (PMID: 8884266) Hasson T. … Jenkins N.A. (Genomics 1996) 2 3
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. High density SNP association study of a major autism linkage region on chromosome 17. (PMID: 17376794) Stone J.L. … Nelson S.F. (Hum. Mol. Genet. 2007) 3 48
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for MYO1D Gene

Sources for MYO1D Gene

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