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MYO1C Gene

protein-coding   GIFtS: 67
GCID: GC17M001367

Myosin IC

  See MYO1C-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin IC1 2     myosin-Ic2
Myosin I Beta2 3     Myosin-I Beta2
MMI-beta2 3     myr22
MMIb2 3     Nuclear Myosin I2
NMI2     Unconventional Myosin-Ic2

External Ids:    HGNC: 75971   Entrez Gene: 46412   Ensembl: ENSG000001978797   OMIM: 6065385   UniProtKB: O001593   

Export aliases for MYO1C gene to outside databases

Previous GC identifers: GC17M001501 GC17M001704 GC17M001319 GC17M001574 GC17M001314


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYO1C Gene:
This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors.
The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The
nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse
ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple
transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has
been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MYO1C Gene:
MYO1C (myosin IC) is a protein-coding gene. Diseases associated with MYO1C include glomerulosclerosis, focal segmental, 6, and deafness, autosomal dominant 4b. GO annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is MYO1D.

UniProtKB/Swiss-Prot: MYO1C_HUMAN, O00159
Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in
intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which
would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by
regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair
cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of
mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the
actin cytoskeleton to cellular membranes (By similarity)
Function: Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal
genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for
the formation of the first phosphodiester bond during transcription initiation (By similarity)

Gene Wiki entry for MYO1C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYO1C gene promoter:
         HNF-4alpha2   Pax-4a   RORalpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MYO1C promoter sequence
   Search Chromatin IP Primers for MYO1C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYO1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

MYO1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO1C gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M001367:  view genomic region     (about GC identifiers)

Start:
1,367,392 bp from pter      End:
1,396,106 bp from pter
Size:
28,715 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MYO1C_HUMAN, O00159 (See protein sequence)
Recommended Name: Unconventional myosin-Ic  
Size: 1063 amino acids; 121682 Da
Subunit: Interacts (via its IQ motifs) with calmodulin. Interacts (via its IQ motifs) with CABP1 and CIB1; the
interaction with CABP1 and CIB1 is calcium-dependent. Interacts (via tail domain) with PLEKHB1 (via PH domain);
the interaction is not affected by the presence or absence of calcium and calmodulin. Interacts with POLR1A and
POLR2A. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C,
ERCC6, MYBBP1A and DDX21 (By similarity). Interacts with RPS6 and actin
Caution: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1
(MYH1)
Sequence caution: Sequence=AAH68013.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAE06097.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAF85599.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q4LE56 Q6NVJ7 Q86Y95
Alternative splicing: 3 isoforms:  O00159-1   O00159-2   O00159-3   (Contains a N-acetylmethionine at position 1)

Explore the universe of human proteins at neXtProt for MYO1C: NX_O00159

Explore proteomics data for MYO1C at MOPED

Post-translational modifications: 

  • Isoform 2 contains a N-acetylmethionine at position 11
  • Ubiquitination2 at Lys188, Lys404, Lys740, Lys868
  • Modification sites at PhosphoSitePlus

  • See MYO1C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001074248.1  NP_001074419.1  NP_203693.3  

    ENSEMBL proteins: 
     ENSP00000352834   ENSP00000412197   ENSP00000459174   ENSP00000437685   ENSP00000459558  
     ENSP00000459271   ENSP00000460831   ENSP00000461175   ENSP00000461682   ENSP00000460415  
     ENSP00000458610   ENSP00000354283  
    Reactome Protein details: O00159

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MYOI: Myosins / Myosin superfamily : Class I

    4 InterPro protein domains:
     IPR010926 Myosin_tail_2
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS
     IPR001609 Myosin_head_motor_dom

    Graphical View of Domain Structure for InterPro Entry O00159

    ProtoNet protein and cluster: O00159

    2 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB010926 Myosin tail 2


    UniProtKB/Swiss-Prot: MYO1C_HUMAN, O00159
    Domain: Binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate
    (PIP2) or inositol 1,4,5-trisphosphate (InsP3). The PIP2-binding site corresponds to a putative PH domain present
    in its tail domain (By similarity)
    Similarity: Contains 2 IQ domains
    Similarity: Contains 1 myosin head-like domain


    Find genes that share domains with MYO1C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYO1C_HUMAN, O00159
    Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in
    intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which
    would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by
    regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair
    cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of
    mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the
    actin cytoskeleton to cellular membranes (By similarity)
    Function: Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal
    genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for
    the formation of the first phosphodiester bond during transcription initiation (By similarity)

         Genatlas biochemistry entry for MYO1C:
    myosin IC,unconventional,apparently non filamentous,homologous to mouse Myo1e

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0003779actin binding IEA--
    GO:0005102receptor binding IPI--
    GO:0005515protein binding IPI--
    GO:0005516calmodulin binding IEA--
         
    Find genes that share ontologies with MYO1C           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MYO1C:
     Increased focal adhesion (FA)  

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Myo1c):
     cellular  hearing/vestibular/ear  hematopoietic system  nervous system  no phenotypic analysis 
     skeleton 

    Find genes that share phenotypes with MYO1C           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MYO1C

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYO1C:
    hsa-mir-324-5p (MIRT043155), hsa-mir-27a-3p (MIRT050021), hsa-mir-181b-5p (MIRT047292), hsa-mir-18a-3p (MIRT040954), hsa-mir-92a-3p (MIRT049220), hsa-mir-34a-5p (MIRT025523), hsa-let-7b-5p (MIRT052105)

    Block miRNA regulation of human, mouse, rat MYO1C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYO1C (see all 56):
    hsa-miR-194* hsa-miR-3678-3p hsa-miR-4291 hsa-miR-3685 hsa-miR-142-5p hsa-miR-3194-5p hsa-miR-330-5p hsa-miR-15a
    SwitchGear 3'UTR luciferase reporter plasmidMYO1C 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYO1C_HUMAN, O00159: Isoform 1: Cytoplasm. Nucleus. Note=Colocalizes with RNA polymerase II. Absent from nucleoli
    and does not colocalize with RNA polymerase I. Translocates to nuclear speckles upon exposure to inhibitors of
    RNA polymerase II transcription
    MYO1C_HUMAN, O00159: Isoform 2: Cytoplasm. Cell membrane (By similarity). Cell projection, stereocilium membrane
    (By similarity). Note=Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on
    the cell membrane. Colocalizes in adipocytes with GLUT4 in actin-based membranes. Localizes transiently at cell
    membrane to region known to be enriched in PIP2. Activation of phospholipase C results in its redistribution to
    the cytoplasm (By similarity)
    MYO1C_HUMAN, O00159: Isoform 3: Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus, nuclear pore complex.
    Note=Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli (By
    similarity). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular
    component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with
    transcription sites. Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes
    in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear
    pore level
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    extracellular5
    nucleus5
    plasma membrane5
    cytosol4
    mitochondrion1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725NOT stress fiber IDA9858156
    GO:0005634nucleus IDA--
    GO:0005643nuclear pore IEA--
    GO:0005654nucleoplasm IEA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with MYO1C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYO1C About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    wtCFTR and delta508 traffic Clathrin coated vesicles formation norm and CF 0.35
    Transport Clathrin coated vesicle cycle0.66
    2PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    3Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    5RhoGDI Pathway
    Fc-GammaR-Mediated Phagocytosis in Macrophages0.33
    RhoGDI Pathway0.33


    Find genes that share SuperPaths with MYO1C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYO1C (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    2 GeneGo (Thomson Reuters) Pathways for MYO1C
        wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
    Transport Clathrin-coated vesicle cycle

    1 BioSystems Pathway for MYO1C
        Insulin Signaling


    2 Reactome Pathways for MYO1C
        Regulation of actin dynamics for phagocytic cup formation
    Translocation of GLUT4 to the plasma membrane


        Pathway & Disease-focused RT2 Profiler PCR Array including MYO1C: 
              mTOR Signaling in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MYO1C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYO1C (O001592, 3 ENSP000003528344) via UniProtKB, MINT, STRING, and/or I2D (see all 149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3, ENSP000003549274MINT-48399 I2D: score=2 STRING: ENSP00000354927
    IKBKGQ9Y6K92, 3MINT-48151 I2D: score=2 
    RIPK3Q9Y5722, 3MINT-49093 I2D: score=2 
    BAZ1BQ9UIG03, ENSP000003424344I2D: score=2 STRING: ENSP00000342434
    CIAO1O760713, ENSP000004182874I2D: score=2 STRING: ENSP00000418287
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006605protein targeting IDA--
    GO:0006612protein targeting to membrane IDA--
    GO:0006810transport ----
    GO:0030335positive regulation of cell migration IMP--
    GO:0038089positive regulation of cell migration by vascular endothelial growth factor signaling pathway IMP--

    Find genes that share ontologies with MYO1C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYO1C

    1 Novoseek inferred chemical compound relationship for MYO1C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 14.2 3 9176160 (3)



    Find genes that share compounds with MYO1C           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYO1C gene (3 alternative transcripts): 
    NM_001080779.1  NM_001080950.1  NM_033375.4  

    Unigene Cluster for MYO1C:

    Myosin IC
    Hs.286226  [show with all ESTs]
    Unigene Representative Sequence: NM_001080779
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000359786(uc002fsp.3) ENST00000438665(uc002fsn.3) ENST00000575158(uc010vqj.1)
    ENST00000545534(uc010vqk.1) ENST00000574341 ENST00000574308 ENST00000572615
    ENST00000575011 ENST00000575864 ENST00000571615 ENST00000573961 ENST00000573198
    ENST00000571851 ENST00000570984 ENST00000576822 ENST00000573853 ENST00000574790
    ENST00000570490
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    hsa-miR-194* hsa-miR-3678-3p hsa-miR-4291 hsa-miR-3685 hsa-miR-142-5p hsa-miR-3194-5p hsa-miR-330-5p hsa-miR-15a
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      QuantiTect SYBR Green Assays in human, mouse, rat MYO1C
      QuantiFast Probe-based Assays in human, mouse, rat MYO1C

    Additional mRNA sequence: 

    AB210015.1 AK172742.1 AK292910.1 AK295761.1 AK304782.1 BC044891.1 BC068013.1 BC127784.1 

    Selected DOTS entries (see all 25):

    DT.95218184  DT.100804719  DT.100824177  DT.97810807  DT.100039696  DT.121010594  DT.100824178  DT.100824172 
    DT.121010581  DT.116085  DT.121010577  DT.121010591  DT.121010596  DT.75176744  DT.97823417  DT.121010584 
    DT.121010599  DT.121010608  DT.121010627  DT.91772225  DT.92012691  DT.95333037  DT.95370958  DT.99991841 

    Selected AceView cDNA sequences (see all 608):

    BQ272345 BM704683 AW006751 CB158188 AI521641 BU845104 CA422782 CA450411 
    BE350889 BQ024404 CO246685 AI432095 BM450184 BM548749 BM708862 AA188499 
    AW733147 BF772015 NM_033375 T35443 BM843842 CB130206 AL602705 AA235595 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYO1C (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
    SP1:        -     -     -     -     -     -                                                     -     -     -                                                   
    SP2:                                      -                                                     -     -     -                                                   
    SP3:                    -     -     -     -                             -                       -     -     -                                                   
    SP4:                                                                                                        -                                                   
    SP5:                    -     -     -     -                                                     -     -     -                                                   

    ExUns: 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b · 29c ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b ^ 38 ^
    SP1:                    -                       -                             -                                                                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for MYO1C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MYO1C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCGTGGG
    MYO1C Expression
    About this image


    MYO1C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Cells Epiblast
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
     
     Umbilical Cord (Extraembryonic Tissues)
    MYO1C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYO1C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.286226
        Pathway & Disease-focused RT2 Profiler PCR Array including MYO1C: 
              mTOR Signaling in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO1C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYO1C gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myo1c1 , 5 myosin IC1, 5 88.76(n)1
    96.72(a)1
      11 (45.92 cM)5
    179131  NM_001080775.11  NP_001074244.11 
     756505045 
    chicken
    (Gallus gallus)
    Aves MYO1C1 myosin IC 75.1(n)
    82.78(a)
      417555  NM_001006220.2  NP_001006220.2 
    lizard
    (Anolis carolinensis)
    Reptilia MYO1C6
    myosin IC
    81(a)
    1 ↔ 1
    AAWZ02038163(168-10400)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686532 hypothetical protein MGC68653 75.62(n)    BC060477.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myo1c1 myosin IC 69.84(n)
    74.53(a)
      566459  XM_689729.6  XP_694821.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta Myo61F1 Myosin 61F 59.17(n)
    52.2(a)
      38153  NM_167870.2  NP_728594.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MYO36
    One of two type I myosins; localizes to actin cort...
    27(a)
    1 → many
    XI(196349-200167) YKL129C


    ENSEMBL Gene Tree for MYO1C (if available)
    TreeFam Gene Tree for MYO1C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYO1C gene
    MYO1D2  MYO15A2  MYO1A2  MYO1F2  MYO1G2  MYO1B2  MYO1E2  MYO15B2  
    MYO1H2  MYO192  
    Selected SIMAP similar genes for MYO1C using alignment to 11 protein entries:     MYO1C_HUMAN (see all proteins) (see all similar genes):
    MYO1H    MYH9    MYO1A    MYO1B    MYO9A    MYO1E
    MYH11    MYO1D    MYO5C    MYH10    MYH2    FLJ00395
    MYO1F variant protein    MYO19    MYO1G    MYO1F    MYO10    MYO9B

    Find genes that share paralogs with MYO1C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for MYO1C (see all 1066)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1146878521,2
    C,F--1367023(+) CCTTAC/TTCTGG 3 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1871896141,2
    --1367056(+) AATATC/TCTTTT 3 -- ds50010--------
    rs64168771,2
    C,F,H--1367122(+) AGGTgG/Tccggg 3 -- ds500125Minor allele frequency- T:0.24NS EA NA WA CSA 2351
    rs1909193341,2
    --1367163(+) TTTGGG/TAGGCC 3 -- ds50010--------
    rs1826275681,2
    --1367259(+) ATTAGC/TCAGGC 3 -- ds50010--------
    rs1881942161,2
    C--1367265(+) CAGGCG/TTGGTG 3 -- ds50010--------
    rs1488909811,2
    C--1367279(+) CATGAC/TGTAGT 3 -- ds50010--------
    rs75016611,2
    C,F,A--1367296(+) tactcA/Gggagg 3 -- ds500111Minor allele frequency- G:0.18NA WA CSA EA 255
    rs80660441,2
    C,F--1367352(+) gagccG/Aagatc 3 -- ds50018Minor allele frequency- A:0.21NA WA CSA 14
    rs753753951,2
    F--1367420(+) AACACG/AAGGCC 3 -- ds50011Minor allele frequency- A:0.03NA 120

    HapMap Linkage Disequilibrium report for MYO1C (1367392 - 1396106 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MYO1C:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676177CNV Deletion23128226
    esv2715464CNV Deletion23290073
    dgv3029n71CNV Loss21882294
    nsv907502CNV Loss21882294
    dgv3028n71CNV Loss21882294
    nsv516805CNV Loss19592680
    nsv907504CNV Loss21882294
    nsv833334CNV Loss17160897

    Human Gene Mutation Database (HGMD): MYO1C
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYO1C
    DNA2.0 Custom Variant and Variant Library Synthesis for MYO1C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606538    OMIM disorders: --

    2 diseases for MYO1C:    
    About MalaCards
    glomerulosclerosis, focal segmental, 6    deafness, autosomal dominant 4b

    1 disease from the University of Copenhagen DISEASES database for MYO1C:
    Sensorineural hearing loss

    Find genes that share disorders with MYO1C           About GenesLikeMe

    Genetic Association Database (GAD): MYO1C
    Human Genome Epidemiology (HuGE) Navigator: MYO1C (3 documents)

    Export disorders for MYO1C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYO1C gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with MYO1C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. (PubMed id 9119401)1, 2, 3, 9 Crozet F.... Petit C. (Genomics 1997)
    2. Are MYO1C and MYO1F associated with hearing loss? (PubMed id 19027848)1, 4 Zadro C....Carella M. (Biochim. Biophys. Acta 2009)
    3. Small ribosomal subunits associate with nuclear myosin and actin in transit to the nuclear pores. (PubMed id 16877530)1, 2 Cisterna B.... Biggiogera M. (FASEB J. 2006)
    4. The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription. (PubMed id 16603771)1, 2 Cavellan E.... Oestlund Farrants A.-K. (J. Biol. Chem. 2006)
    5. Nuclear distribution of actin and myosin I depends on transcriptional activity of the cell. (PubMed id 16133118)1, 2 Kysela K....Hozak P. (Histochem. Cell Biol. 2005)
    6. A myosin I isoform in the nucleus. (PubMed id 11030652)1, 9 Pestic-Dragovich L....de Lanerolle P. (Science 2000)
    7. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    8. The myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signaling. (PubMed id 23262137)1 Tiwari A....Choudhury A. (Am. J. Physiol. Heart Circ. Physiol. 2013)
    9. Identification of signals that facilitate isoform specific nucleolar localization of myosin IC. (PubMed id 23438938)1 Schwab R.S....Hofmann W.A. (Exp. Cell Res. 2013)
    10. Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression. (PubMed id 23555303)1 Sarshad A....Percipalle P. (PLoS Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4641 HGNC: 7597 AceView: MYO1C Ensembl:ENSG00000197879 euGenes: HUgn4641
    ECgene: MYO1C H-InvDB: MYO1C

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MYO1C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MYO1C gene:
    Search GeneIP for patents involving MYO1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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