MYO1C Gene
protein-coding GIFtS: 62
GCID: GC17M001367
|
|
myosin IC
| |
Aliases
for MYO1C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Myosin IC1 2 | | NMI2 | | Myr21 | | Myosin-Ic1 | | Myosin I Beta2 3 | | Myosin-I Beta2 | | MMI-Beta1 | | Nuclear Myosin I2 | | MMIb2 3 | | Unconventional Myosin-Ic2 |
Export aliases for MYO1C gene to outside databasesPrevious GC identifers: GC17M001501 GC17M001704 GC17M001319 GC17M001574 GC17M001314 |
Summaries
for MYO1C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MYO1C:
This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. Theprotein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclearisoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of thisprotein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variantsencoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosinIC in the literature, but it is a distinct locus on chromosome 19. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MYO1C_HUMAN, O00159Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellularmovements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relativeto actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement ofintracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of theinner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereociliaof vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (Bysimilarity)Function: Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes.Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for theformation of the first phosphodiester bond during transcription initiation (By similarity)
Gene Wiki entry for MYO1C
|
Genomic Views
for MYO1C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MYO1C gene promoter:
HNF-4alpha2 Pax-4a RORalpha2 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MYO1C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYO1C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13.3MYO1C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M001367: view genomic region
(about GC identifiers)
Start:
|
1,367,392 bp from pter |
End:
|
1,396,106 bp from pter |
Size:
|
28,715 bases |
Orientation:
|
minus strand |
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Proteins
for MYO1C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MYO1C_HUMAN, O00159 (See
protein sequence)Recommended Name: Unconventional myosin-Ic Size: 1063 amino acids; 121682 Da
Subunit: Interacts (via its IQ motifs) with calmodulin. Interacts (via its IQ motifs) with CABP1 and CIB1; theinteraction with CABP1 and CIB1 is calcium-dependent. Interacts (via tail domain) with PLEKHB1 (via PH domain); theinteraction is not affected by the presence or absence of calcium and calmodulin. Interacts with POLR1A and POLR2A.Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A andDDX21 (By similarity). Interacts with RPS6 and actin
Subcellular location: Cytoplasm. Cell membrane (By similarity). Cell projection, stereocilium membrane (By similarity).Note=Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane.Colocalizes in adipocytes with GLUT4 in actin-based membranes. Localizes transiently at cell membrane to region knownto be enriched in PIP2. Activation of phospholipase C results in its redistribution to the cytoplasm (By similarity)
Subcellular location: Isoform 3: Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus, nuclear pore complex.Note=Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli (By similarity).In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC).Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites.Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level
Caution: Represents a unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1)
Sequence caution: Sequence=AAH68013.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAE06097.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAF85599.1;Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q4LE56 Q6NVJ7 Q86Y95Alternative splicing: 3 isoforms: O00159-1 O00159-2 O00159-3 (Gene prediction based on EST data)Explore the universe of human proteins at neXtProt for MYO1C: NX_O00159
Post-translational modifications:
Isoform 2 contains a N-acetylmethionine at position 11
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00159
MYO1C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001074248.1 NP_001074419.1 NP_203693.3
ENSEMBL proteins: ENSP00000352834 ENSP00000412197 ENSP00000459174 ENSP00000437685 ENSP00000459558 ENSP00000459271 ENSP00000460831 ENSP00000461175 ENSP00000461682 ENSP00000460415 ENSP00000458610 ENSP00000354283 Reactome Protein details: O00159
Human Recombinant Protein Products:
Gene Ontology (GO): 5/20 cellular component terms (GO ID links to tree view) (see all 20): About this table
MYO1C for ontologies About GeneDecksing
MYO1C Antibody Products:
Assay Products for MYO1C: |
Protein
Domains /
Families
for MYO1C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MYO1C for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00159ProtoNet protein and cluster: O00159 2 Blocks protein families: IPB000048 IQ calmodulin-binding region IPB010926 Myosin tail 2
UniProtKB/Swiss-Prot: MYO1C_HUMAN, O00159Domain: Binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate (PIP2) orinositol 1,4,5-trisphosphate (InsP3). The PIP2-binding site corresponds to a putative PH domain present in its taildomain (By similarity)Similarity: Contains 2 IQ domainsSimilarity: Contains 1 myosin head-like domain |
Function
for MYO1C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MYO1C_HUMAN, O00159Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellularmovements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relativeto actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement ofintracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of theinner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereociliaof vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (Bysimilarity)Function: Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes.Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for theformation of the first phosphodiester bond during transcription initiation (By similarity) Genatlas biochemistry entry for MYO1C:myosin IC,unconventional,apparently non filamentous,homologous to mouse Myo1e
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYO1C (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYO1C (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): MYO1C (NM_001080950) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYO1C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO1C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO1C |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
MYO1C for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MYO1C:
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Myo1c):
MYO1C for phenotypes About GeneDecksing
|
Pathways & Interactions
for MYO1C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Clathrin-dependent protein traffic | | | 2 | Regulation of actin dynamics for phagocytic cup formation | | | 3 | PAK Pathway | | | 4 | Immune System | | | 5 | Membrane Trafficking | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for MYO1C
5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYO1C (see all 11)
2  GeneGo (Thomson Reuters) Pathways for MYO1C
1  BioSystems Pathway for MYO1C
5/8 
Reactome Pathways for MYO1C (see all 8)
MYO1C for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYO1C
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/92 Interacting proteins for MYO1C (O001592, 3 ENSP000003528344) via UniProtKB, MINT, STRING, and/or I2D (see all 92)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
MYO1C for ontologies About GeneDecksing
|
Drugs & Compounds
for MYO1C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MYO1C for compounds About GeneDecksing
 Browse Tocris compounds for MYO1C
1 Novoseek chemical compound relationship for MYO1C gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| atp |
14.2 |
3 |
9176160 (3) |
Search CenterWatch for drugs/clinical trials and news about MYO1C
|
Transcripts
for MYO1C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MYO1C gene (3 alternative transcripts): NM_001080779.1 NM_001080950.1 NM_033375.4 Unigene Cluster for MYO1C: Myosin IC Hs.286226 [show with all ESTs]Unigene Representative Sequence: NM_00108077918/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21): ENST00000359786(uc002fsp.3) ENST00000438665(uc002fsn.3) ENST00000575158(uc010vqj.1)
ENST00000545534(uc010vqk.1) ENST00000574341 ENST00000574308 ENST00000572615
ENST00000575011 ENST00000575864 ENST00000571615 ENST00000573961 ENST00000573198
ENST00000571851 ENST00000570984 ENST00000576822 ENST00000573853 ENST00000574790
ENST00000570490
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYO1C (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYO1C (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): MYO1C (NM_001080950) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYO1C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO1C |
Additional cDNA sequence: AB210015.1 AK172742.1 AK292910.1 AK295761.1 AK304782.1 BC044891.1 BC068013.1 BC127784.1 24/25 DOTS entries (see all 25): DT.95218184 DT.100804719 DT.100824177 DT.97810807 DT.100039696 DT.121010594 DT.100824178 DT.100824172 DT.121010581 DT.116085 DT.121010577 DT.121010591 DT.121010596 DT.75176744 DT.97823417 DT.121010584 DT.121010599 DT.121010608 DT.121010627 DT.91772225 DT.92012691 DT.95333037 DT.95370958 DT.99991841 24/608 AceView cDNA sequences (see all 608): AW024806 BU192419 BQ447654 CA450411 AI679978 BX342719 BQ920295 BU855078 CF528288 BU947603 BM509825 CB164325 AA035675 BM912003 AA132603 AL602705 AW087696 BM505166 BQ024404 BU616448 AI753752 BM548749 AI810921 BI868711
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MYO1C (see all 13) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · |
|---|
|
| SP1: | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | |
| ExUns: | 19b | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | · | 29c | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37a | · | 37b | ^ | 38 | ^ |
|---|
|
| SP1: | | | | | | | - | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MYO1C
|
Expression
for MYO1C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MYO1C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAGCGTGGG
About this image
See MYO1C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYO1C
SOURCE GeneReport for Unigene cluster: Hs.286226
SABiosciences Expression via Pathway-Focused PCR Array including MYO1C:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYO1C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYO1C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYO1C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYO1C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO1C |
Orthologs
for MYO1C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MYO1C gene from 5/21 species (see all 21) About this table
ENSEMBL Gene Tree for MYO1C (if available)
TreeFam Gene Tree for MYO1C (if available) |
Paralogs
for MYO1C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MYO1C gene
- MYO1D2 MYO1A2 MYO1F2 MYO1G2 MYO1B2 MYO1E2 MYO1H2 MYO192
18/33 SIMAP similar genes for MYO1C using alignment to 11 protein entries: MYO1C_HUMAN (see all proteins)
(see all similar genes):MYO1H MYH9 MYO1B MYO1A MYO9A MYO1E
MYH11 MYO1D MYH10 MYO5C MYH2 FLJ00395
MYO1F variant protein MYO19 MYO1G MYO10 MYO9B variant protein MYO15B
MYO1C for paralogs About GeneDecksing
|
Genomic Variants
for MYO1C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MYO1C (1367392 - 1396106 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MYO1C: --
Human Gene Mutation Database (HGMD): MYO1C
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYO1C |
|
Disorders
/ Diseases
for MYO1C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MYO1C for disorders About GeneDecksing
OMIM gene information: 606538
OMIM disorders: --
5  diseases for MYO1C: About MalaCardssitus inversus hearing loss amebiasis breast cancer
neuronitis
1 disease from the University of Copenhagen DISEASES database for MYO1C:Amebiasis Human Genome Epidemiology (HuGE) Navigator: MYO1C (3 documents)
Export disorders for MYO1C gene to outside databases
|
Publications
for MYO1C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MYO1C gene, integrated from 9 sources (see all 60):
(articles sorted by number of sources associating them with MYO1C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. (PubMed id 9119401)1, 2, 3, 9 Crozet F.... Petit C. (1997)
- Small ribosomal subunits associate with nuclear myosin and actin in transit to the nuclear pores. (PubMed id 16877530)1, 2 Cisterna B.... Biggiogera M. (2006)
- The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription. (PubMed id 16603771)1, 2 Cavellan E....Farrants A.K. (2006)
- Nuclear distribution of actin and myosin I depends on transcriptional activity of the cell. (PubMed id 16133118)1, 2 Kysela K....Hozak P. (2005)
- A myosin I isoform in the nucleus. (PubMed id 11030652)1, 9 Pestic-Dragovich L....de Lanerolle P. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Sp1 phosphorylation by cyclin-dependent kinase 1/cycli n B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (2012)
- Myo1c regulates lipid raft recycling to control cell s preading, migration and Salmonella invasion. (PubMed id 22328521)1 Brandstaetter H....Buss F. (2012)
- Comprehensive analysis of interactions between the Src -associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. (PubMed id 22745667)1 Asbach B....Wagner R. (2012)
- Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
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External Searches for MYO1C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing MYO1C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing MYO1C gene
(According to HUGE)
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Specialized Databases showing MYO1C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
| Name | Description |
| PharmGKB entry for MYO1C | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MYO1C gene:
Search GeneIP for patents involving MYO1C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MYO1C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MYO1C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYO1C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYO1C | | | OriGene Protein Over-expression Lysate for MYO1C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MYO1C | | OriGene 3'-UTR Clone for MYO1C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYO1C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYO1C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MYO1C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYO1C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYO1C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYO1C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYO1C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYO1C |
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| | | | Search Tocris compounds for MYO1C |
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 | | | MYO1C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO1C |
|  |  |  | | | | ThermoFisher Antibodies for MYO1C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO1C |
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